CN105866426B - 用于检测补体结合性抗体的方法和组合物 - Google Patents

用于检测补体结合性抗体的方法和组合物 Download PDF

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Publication number
CN105866426B
CN105866426B CN201610218019.2A CN201610218019A CN105866426B CN 105866426 B CN105866426 B CN 105866426B CN 201610218019 A CN201610218019 A CN 201610218019A CN 105866426 B CN105866426 B CN 105866426B
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complement
hla
antibody
sample
agi
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CN105866426A (zh
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D·B·蒂安
G·陈
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326Magnetic particles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4716Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201610218019.2A 2008-12-01 2009-11-25 用于检测补体结合性抗体的方法和组合物 Active CN105866426B (zh)

Applications Claiming Priority (3)

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US11894908P 2008-12-01 2008-12-01
US61/118,949 2008-12-01
CN2009801446394A CN102203610A (zh) 2008-12-01 2009-11-25 用于检测补体结合性抗体的方法和组合物

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CN105866426B true CN105866426B (zh) 2018-11-23

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US (1) US10338080B2 (cg-RX-API-DMAC7.html)
EP (2) EP3460480B1 (cg-RX-API-DMAC7.html)
JP (2) JP5792626B2 (cg-RX-API-DMAC7.html)
CN (2) CN105866426B (cg-RX-API-DMAC7.html)
AU (1) AU2009322607B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0923199B8 (cg-RX-API-DMAC7.html)
CA (1) CA2740192C (cg-RX-API-DMAC7.html)
WO (1) WO2010065425A1 (cg-RX-API-DMAC7.html)

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CN105308457B (zh) * 2013-03-14 2018-07-10 斯坦福大学托管董事会 检测供体特异性抗体的方法和用于实施所述方法的系统
US20160041185A1 (en) * 2013-03-14 2016-02-11 The Board Of Trustees Of The Leland Stanford Junior University Methods of Detecting Complement Fixing and Non-Complement Fixing Antibodies and Systems for Practicing the Same
SG10201710758PA (en) 2013-07-09 2018-02-27 Annexon Inc Anti-complement factor c1q antibodies and uses thereof
ES3013108T3 (en) * 2014-11-05 2025-04-11 Annexon Inc Humanized anti-complement factor c1q antibodies and uses thereof
HK1259251A1 (zh) 2015-04-06 2019-11-29 Bioverativ Usa Inc. 人源化抗c1s抗体及其使用方法
US10527613B2 (en) 2015-11-10 2020-01-07 The Board Of Trustees Of The Leland Stanford Junior University Biomarker detection methods and systems and kits for practicing same
WO2017091719A1 (en) 2015-11-24 2017-06-01 Annexon, Inc. Anti-complement factor c1q fab fragments and uses thereof
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WO2017187656A1 (ja) * 2016-04-27 2017-11-02 株式会社Jimro 抗医薬品抗体の測定方法
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EP3525583B8 (en) 2016-10-12 2025-09-10 Bioverativ USA Inc. Anti-c1s antibodies and methods of use thereof
WO2018140655A2 (en) * 2017-01-25 2018-08-02 Northeastern University Electrochemical antibody-based biosensor
CN114910634B (zh) * 2017-10-26 2025-05-23 科美诊断技术股份有限公司 一种无基质效应的均相免疫检测试剂盒及其分析方法和应用
CN107976535B (zh) * 2017-11-03 2020-03-20 科美诊断技术股份有限公司 一种检测样本中目标IgM抗体的均相免疫检测试剂盒及其使用方法和应用
CN109991405B (zh) * 2017-12-29 2023-01-24 上海索昕生物科技有限公司 一种免疫检测试剂盒及其应用
JP7153493B2 (ja) * 2018-07-27 2022-10-14 シスメックス株式会社 生体粒子の測定方法、非特異シグナルの検出方法、生体粒子測定方法及び生体粒子を検出するための試薬キット
JP7153494B2 (ja) * 2018-07-27 2022-10-14 シスメックス株式会社 生体粒子の測定方法、非特異シグナルの検出方法、生体粒子測定方法及び生体粒子を検出するための試薬キット
EP3965807A4 (en) * 2019-05-06 2023-08-30 The Regents of the University of California NON-HLA MARKERS OF TRANSPLANT REJECTION
CN111812336A (zh) * 2020-08-10 2020-10-23 苏州康和顺医疗技术有限公司 用于检测冠状病毒抗体的检测试剂盒及其制备方法
WO2022076865A1 (en) * 2020-10-09 2022-04-14 Takeda Vaccines, Inc. Methods for determining complement-fixing antibodies
EP4314824A1 (en) * 2021-03-31 2024-02-07 Takeda Vaccines, Inc. Methods for characterizing the immune response of a subject to a dengue virus composition
EP4089413A1 (en) * 2021-05-12 2022-11-16 Cisbio Bioassays Method for determining the binding of an antibody to the complement component 1q (c1q)
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CN118604345A (zh) * 2024-05-31 2024-09-06 上海览屹医药科技有限公司 酶联免疫方法测定单克隆抗体浓度
CN120142127A (zh) * 2025-05-16 2025-06-13 上海荻硕贝肯基因科技有限公司 一种供者特异性抗体的检测方法

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EP3460480A1 (en) 2019-03-27
CA2740192A1 (en) 2010-06-10
US20110281757A1 (en) 2011-11-17
EP3460480B1 (en) 2022-11-02
JP2012510618A (ja) 2012-05-10
EP2353005A1 (en) 2011-08-10
US10338080B2 (en) 2019-07-02
BRPI0923199A2 (pt) 2016-02-16
BRPI0923199B8 (pt) 2021-07-27
AU2009322607B2 (en) 2015-05-14
CA2740192C (en) 2019-12-31
EP2353005A4 (en) 2012-10-17
CN102203610A (zh) 2011-09-28
EP2353005B1 (en) 2018-10-03
WO2010065425A1 (en) 2010-06-10
AU2009322607A1 (en) 2010-06-10
CN105866426A (zh) 2016-08-17
JP2015007651A (ja) 2015-01-15
JP5792626B2 (ja) 2015-10-14
BRPI0923199B1 (pt) 2020-10-20

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