CN105854717B - One kind is based on Piezoelectric Driving integrated form micro-mixer - Google Patents
One kind is based on Piezoelectric Driving integrated form micro-mixer Download PDFInfo
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- CN105854717B CN105854717B CN201610317989.8A CN201610317989A CN105854717B CN 105854717 B CN105854717 B CN 105854717B CN 201610317989 A CN201610317989 A CN 201610317989A CN 105854717 B CN105854717 B CN 105854717B
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- hybrid chamber
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- reflux
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- 239000012530 fluid Substances 0.000 claims abstract description 31
- 238000010992 reflux Methods 0.000 claims abstract description 27
- 239000000758 substrate Substances 0.000 claims abstract description 10
- 239000011259 mixed solution Substances 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims description 6
- 230000008676 import Effects 0.000 claims description 2
- 238000002156 mixing Methods 0.000 abstract description 11
- 238000009792 diffusion process Methods 0.000 abstract description 6
- 238000004886 process control Methods 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 14
- 230000000694 effects Effects 0.000 description 10
- 238000010586 diagram Methods 0.000 description 7
- 238000000034 method Methods 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 2
- 238000004880 explosion Methods 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
- B01F33/3017—Mixing chamber
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micromachines (AREA)
- Reciprocating Pumps (AREA)
Abstract
The invention discloses one kind to be based on Piezoelectric Driving integrated form micro-mixer, body is made up of the affixed upper gasket bottom formed, middle part reflux layer, bottom vibration level, upper gasket bottom is provided with top hybrid chamber, it is integrated with multiple fluid intakes, mixed solution outlet, middle part reflux layer is provided with return flow line clockwise, return flow line counterclockwise, middle part hybrid chamber, it is integrated with backflow piezoelectric micropump and chip electrode, bottom vibration level is provided with inlet and outlet microchannel, bottom hybrid chamber, is integrated with disengaging stream piezoelectric micropump, oscillator substrate；Each hybrid chamber is concentric and internal diameter is identical.The micro-mixer increases the contact area between fluid, strengthens the convection current between fluid and diffusion, be a kind of mixing efficiency height, the micro-mixer of process control by alternative expression circulating reflux and reciprocating sustained vibration.
Description
Technical field
The present invention relates to Microfluidic Mixing technical field, especially relates to Piezoelectric Driving integrated form micro-mixer.
Background technology
Microfluid mixer is one of micro-fluidic chip (microfluidic chip) important component, is mainly used in realizing
Lot of trace reagent fast and effectively mixes, and has in fields such as chemical synthesis, biological respinse, life sciences before being widely applied very much
Scape.For the channel design of micro-mixer generally in micron dimension, the Reynolds number of fluid is very small, and fluid is in laminar condition, fluid
Between rely primarily on the mixing of molecule diffusion, and to reach and be thoroughly mixed, need considerably long incorporation time.This causes miniflow
The advantage rapidly and efficiently analyzed is controlled to weaken or even disappear, therefore, carried out under minute yardstick the quick mixing of fluid to it is micro-fluidic extremely
Close important.
In order to improve the mixing efficiency of fluid, it is necessary to take effective manner increase micro- contact area between fluid or
Strengthen convection current and diffusion effect.At present, according to whether there is outside energy driving micro-mixer can be divided into two major classes：Active microring array
Device and passive type micro-mixer.Passive mixer generally use has the special knot in the microchannel or microchannel of labyrinth
Structure, increase micro- contact area as far as possible to improve mixing efficiency, its shortcoming is big difficulty of processing, mixed effect and controllability
Difference.Active micro-mixer needs external energy driving to be mixed, and mainly includes：Micro- stirring, pressure disturbance, acoustic perturbation,
Magnetically-actuated, electrofluid driving etc., the advantage is that good mixing effect and mixed process are controllable, but can also have processing technology and answer
It is miscellaneous, processing cost is expensive, the problems such as not easy of integration.
Found through being retrieved to existing literature, China Patent No.：CN 102553482A, proprietary term：Novel counter-current type microring array
Device, it which disclose a kind of high backflow passive microfluid mixer.The micro-mixer is left by setting using Coanda effect
Right symmetric feed-back passage causes backflow, and backflow extends the incorporation time of fluid and promotes to form vortex, increases between fluid
Contact area.But still have the following disadvantages：For the fluid of low reynolds number, its reflux ratio and mixing intensity are poor, structure ginseng
Number is difficult to determine, and mixed process is uncontrollable.
The content of the invention
In order to overcome above-mentioned the shortcomings of the prior art, the invention provides one kind based on Piezoelectric Driving it is integrated decline it is mixed
Clutch, make solution mixing velocity faster, mixed effect is more preferable and mixed process is more controllable.
The technical solution adopted in the present invention is：One kind is provided and is based on Piezoelectric Driving integrated form micro-mixer, body is by solid
Upper gasket bottom, middle part reflux layer, the bottom vibration level composition connect, upper gasket bottom are provided with top hybrid chamber, are integrated with
Multiple fluid intakes, mixed solution outlet, middle part reflux layer mix provided with return flow line clockwise, return flow line counterclockwise, middle part
Chamber is closed, is integrated with backflow piezoelectric micropump and chip electrode, bottom vibration level is provided with inlet and outlet microchannel, bottom hybrid chamber,
It is integrated with disengaging stream piezoelectric micropump, oscillator substrate；Each hybrid chamber is concentric and internal diameter is identical.
The outer wall of bottom vibration level import microchannel is tangent with hybrid chamber, and rotation direction is consistent, and fluid passes through certainly
Body flows to form eddy flow；The outer wall of middle part reflux layer return flow line clockwise is tangent with hybrid chamber, and rotation direction is clockwise, fluid
By clockwise backflow, eddy flow clockwise is formed in hybrid chamber；Middle part reflux layer is counterclockwise, and return flow line outer wall is equal
Tangent with hybrid chamber, fluid is flowed back by counter clockwise direction, and eddy flow counterclockwise is formed in hybrid chamber.
Alternate cycles act on two kinds of reflux types successively, significantly enhance the mixed effect of solution.
Piezoelectric vibrator substrate is driven by continuous alternating signal, it is different based on frequency, it is at single order or multistage mould
State is vibrated, and strengthens convection current and diffusion between fluid, improves mixing efficiency.
Integrated backflow piezoelectric micropump can be to have valve pump or valveless pump, and quantity is two or more；Fluid intake
Quantity is two or more.
The present invention operation principle be：Tangent multiple rotation direction identical runners are easy to stream of the fluid by itself with cavity
Move and cyclonic effect is produced in chamber；Piezoelectric micropump is to be deformed piezoelectric vibrator using the inverse piezoelectric effect of piezoelectric ceramics,
Pump chamber change is caused to realize the one-way flow of fluid by deformation；Oscillator substrate is to be in single order or multistage using piezoelectric vibrator
Modal vibration, act in microfluid, strengthen convection current and diffusion between fluid.
Compared with prior art, the beneficial effects of the invention are as follows：By alternative expression circulating reflux and reciprocating modal vibration two
Kind mode collective effect is the micro-mixer that a kind of initiative is stronger, process is more controllable in microring array.Possessing extremely strong mix
Close on capability foundation discussion, not only can quickly mix the solution of high reynolds number, also can efficiently mix the solution of low reynolds number, tool
There is the vast scope of application.
Brief description of the drawings
Below in conjunction with the accompanying drawings and embodiment the present invention is further described.In accompanying drawing：
Fig. 1 is three-dimensional structure installation diagram of the present invention.
Fig. 2 is depression angle Structure explosion diagram of the present invention.
Fig. 3 is upward view angle Structure explosion diagram of the present invention.
Fig. 4 is upper substrate Rotating fields schematic diagram of the present invention.
Fig. 5 is reflux layer structural representation in middle part of the present invention.
Fig. 6 is vibration level structural representation in bottom of the present invention.
Fig. 7 is that gateway of the present invention flows to schematic diagram.
Fig. 8 is reflux layer counter clockwise flow of the present invention to schematic diagram.
Fig. 9 is that reflux layer of the present invention flows to schematic diagram clockwise.
Wherein：1st, mixed solution exports；2nd, valve free pump A；3rd, fluid intake one；4th, oscillator substrate；5th, there is valve Micropump A；
6th, chip electrode；7th, valve free pump B；8th, middle part reflux layer；9th, bottom vibration level；10th, upper gasket bottom；11st, valve free pump C；
12nd, there is valve Micropump B；13rd, fluid intake two；14th, valve free pump D；15th, there is valve Micropump C.
Embodiment
Fig. 1, Fig. 2, Fig. 3 are referred to, to mix two kinds of solution (solution A and solution B), the power source for being driven in and out stream is to have
Valve Micropump, the power source to flow back is driven to illustrate the present invention exemplified by 4 piezoelectricity valve free pumps.The present invention it is affixed by three parts and
Into upper gasket bottom (10) is integrated with fluid intake one (3), fluid intake two (13), mixed solution outlet (1)；Flow back at middle part
Layer (8) is integrated with valve free pump A (2), valve free pump B (7), valve free pump C (11), valve free pump D (14) and chip electrode
(6)；Bottom vibration level (9) is integrated with oscillator substrate (4), has valve Micropump A (5), have valve Micropump B (12), have valve Micropump C (15).
As shown in figure 4, upper gasket bottom (10) be provided with top hybrid chamber (1001), upper entrance passage one (1002), on
Portion's access road two (1004), upper outlet passage (1003).As shown in figure 5, middle part reflux layer (8) is provided with middle part hybrid chamber
(803), Micropump cavity A (802) and runner A1 (801), runner A2 (804), Micropump cavity B (806) and runner B1
(807), runner B2 (805), Micropump cavity C (810) and runner C1 (809), runner C2 (811), Micropump cavity D (814) with
And runner D1 (815), runner D2 (813), centre entrance passage one (816), centre entrance passage two (808), centre exit lead to
Road (812).As shown in fig. 6, bottom vibration level (9) is provided with bottom hybrid chamber (901), lower entrances runner one (904), entrance stream
Road two (902), lower part outlet runner (903).Each hybrid chamber is concentric and internal diameter is identical.
During work, solution A has valve Micropump A (5) drivings by piezoelectricity, by fluid intake one (3), upper entrance passage one
(1004), centre entrance passage one (816), lower entrances runner one (904) are flowed into bottom hybrid chamber (901), while B solution
There are valve Micropump B (12) drivings by piezoelectricity, by fluid intake two (13), upper entrance passage two (1002), centre entrance passage
Two (808), lower entrances runner two (902) are flowed into bottom hybrid chamber (901), due to bottom gateway runner outer wall and bottom
Hybrid chamber is tangent and rotation direction is consistent, and therefore, fluid can form eddy flow in bottom by the flowing of itself in hybrid chamber (901),
Preliminary microring array is carried out to solution.Hereafter it is final mixed after following reflux type one, the backflow of the alternate cycles of reflux type two
The solution got togather has valve Micropump C (15) drivings by piezoelectricity, by lower part outlet runner (903), by centre exit passage
(812), upper outlet passage (1003) is as shown in Figure 7 from mixed solution outlet (1) outflow, flow direction signal.
Reflux type one：Valve free pump A (2), valve free pump C (11) work, and mixed solution is through runner A1 (801), runner
C1 (809) separately flows into cavity A (802), cavity C (810), and flows back to middle part from runner A2 (804), runner C2 (811) respectively
Hybrid chamber (803), backflow is formed, due to runner A1 (801), runner A2 (804), runner C1 (809), C2 runners (811) outer wall
Tangent with hybrid chamber and rotation direction is counterclockwise, therefore, eddy flow counterclockwise is produced in hybrid chamber, flow direction signal is as shown in Figure 8.
Reflux type two：Piezoelectricity valve free pump B (7), valve free pump D (14) work, mixed solution through runner B1 (807),
Runner D1 (815) separately flows into cavity B (806), cavity D (814), and is flowed back to respectively from runner B2 (805), runner D2 (813)
Middle part hybrid chamber (803), backflow is formed, because runner B1 (807), B2 (805), D1 (815), D2 (813) outer wall are with mixing
Chamber is tangent and rotation direction is clockwise, therefore, eddy flow clockwise is produced in hybrid chamber, flow direction signal is as shown in Figure 9.
Cycle alternation works two kinds of active reflux types successively, increases the contact area between fluid, solution is mixed more
Increase effect.
Oscillator substrate (4) is constantly in single order or multi-modes vibration in mixed process, enhances convection current between fluid
With diffusion, solution is set to mix more abundant.
Above-mentioned piezoelectricity valve free pump A (2), valve free pump B (7), valve free pump C (11) valve free pump D (14), piezoelectricity have
Valve Micropump A (5), there is valve Micropump B (12), there is valve Micropump C (15), oscillator substrate (4) to be controlled by chip electrode (6) with outside
Device connects.
Claims (4)
1. one kind is based on Piezoelectric Driving integrated form micro-mixer, it is characterised in that：Body by the affixed upper gasket bottom formed, in
Portion's reflux layer, bottom vibration level composition, upper gasket bottom are provided with top hybrid chamber, are integrated with multiple fluid intakes, mixed solution
Outlet, middle part reflux layer are provided with return flow line clockwise, return flow line counterclockwise, middle part hybrid chamber, are integrated with backflow piezoelectric micromotor
Pump and chip electrode, bottom vibration level be provided with inlet and outlet microchannel, bottom hybrid chamber, be integrated with disengaging stream piezoelectric micropump,
Oscillator substrate；Each hybrid chamber is concentric and internal diameter is equal.
2. one kind according to claim 1 is based on Piezoelectric Driving integrated form micro-mixer, it is characterised in that：Bottom vibration level
The outer wall of import microchannel is tangent with hybrid chamber, and rotation direction is consistent；Outside middle part reflux layer return flow line clockwise
Wall is tangent with hybrid chamber, and rotation direction is clockwise；Middle part reflux layer is counterclockwise, and return flow line outer wall is tangent with hybrid chamber, and
Rotation direction is counterclockwise.
3. one kind according to claim 1 is based on Piezoelectric Driving integrated form micro-mixer, it is characterised in that：Middle part reflux layer
Reflux type is suitable, the counterclockwise alternative expression circulating reflux of piezoelectric micropump driving, and piezoelectric micropump can be to have valve or valveless micro-
Pump.
4. one kind according to claim 1 is based on Piezoelectric Driving integrated form micro-mixer, it is characterised in that：Bottom vibration level
Oscillator base drive signal is continuous alternating signal, different based on frequency, and mode of vibration is that single order or multi-modes vibrate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610317989.8A CN105854717B (en) | 2016-05-13 | 2016-05-13 | One kind is based on Piezoelectric Driving integrated form micro-mixer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610317989.8A CN105854717B (en) | 2016-05-13 | 2016-05-13 | One kind is based on Piezoelectric Driving integrated form micro-mixer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105854717A CN105854717A (en) | 2016-08-17 |
| CN105854717B true CN105854717B (en) | 2018-04-03 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113289529B (en) * | 2021-05-10 | 2022-07-12 | 浙江大学 | Microfluid mixer based on piezoelectric type synthetic jet technology and mixing method thereof |
| CN114308160B (en) * | 2021-12-29 | 2023-06-20 | 臻准生物科技（上海）有限公司 | Digital PCR microcavity chip and preparation method |
| LU102963B1 (en) | 2022-05-25 | 2023-12-04 | Stratec Se | System for the microfluidic distribution of fluids |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6494433B2 (en) * | 2000-06-06 | 2002-12-17 | The Regents Of The University Of Michigan | Thermally activated polymer device |
| CN1584601A (en) * | 2003-08-20 | 2005-02-23 | 中国科学院大连化学物理研究所 | Sample feeding method for micro-current controlling chip based pressure and electric power combination |
| CN205627815U (en) * | 2016-05-13 | 2016-10-12 | 吉林大学 | Based on integrated blender that declines of piezoelectricity drive |
-
2016
- 2016-05-13 CN CN201610317989.8A patent/CN105854717B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6494433B2 (en) * | 2000-06-06 | 2002-12-17 | The Regents Of The University Of Michigan | Thermally activated polymer device |
| CN1584601A (en) * | 2003-08-20 | 2005-02-23 | 中国科学院大连化学物理研究所 | Sample feeding method for micro-current controlling chip based pressure and electric power combination |
| CN205627815U (en) * | 2016-05-13 | 2016-10-12 | 吉林大学 | Based on integrated blender that declines of piezoelectricity drive |
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| CB03 | Change of inventor or designer information |
Inventor after: Liu Guojun Inventor after: Pei Xiaohan Inventor after: Li Xinbo Inventor after: Wu Yue Inventor after: Liu Jianfang Inventor after: Yang Zhigang Inventor after: Ma Xiang Inventor after: Tang Chunxiu Inventor after: Liang Shihai Inventor after: Wang Tengfei Inventor after: Jiang Feng Inventor after: Zhang Yanyan Inventor after: Zhao Xin Inventor after: Hong Wen Inventor before: Liu Guojun Inventor before: Li Xinbo Inventor before: Wu Yue Inventor before: Liu Jianfang Inventor before: Yang Zhigang Inventor before: Tang Chunxiu Inventor before: Liang Shihai Inventor before: Wang Tengfei Inventor before: Jiang Feng Inventor before: Zhang Yanyan Inventor before: Zhao Xin Inventor before: Hong Wen Inventor before: Pei Xiaohan |
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Effective date of registration: 20180912 Address after: 213164 Science and Technology Branch of Changzhou Science and Education City, Jiangsu Province Patentee after: Changzhou angde Industrial Equipment Technology Co. Ltd. Address before: 130012 No. 2699 Qianjin Street, Jilin, Changchun Patentee before: Jilin University |
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Effective date of registration: 20181214 Address after: 213164 Room 2521, North Building, Huiyan Building, 18 Changwuzhong Road, Wujin District, Changzhou City, Jiangsu Province Patentee after: Changzhou Weitu Fluid Technology Co. Ltd. Address before: 213164 Science and Technology Branch of Changzhou Science and Education City, Jiangsu Province Patentee before: Changzhou angde Industrial Equipment Technology Co. Ltd. |
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| CP02 | Change in the address of a patent holder | ||
| CP02 | Change in the address of a patent holder |
Address after: 213164 room 2521, North Tower, Hui Yan building, Changzhou science and Education Town, 18 Wujin Road, Wujin, Changzhou. Patentee after: Changzhou Weitu Fluid Technology Co. Ltd. Address before: 213164 room 2521, North Tower, Hui Yan building, Changzhou science and Education Town, 18 Wujin Road, Wujin, Changzhou. Patentee before: Changzhou Weitu Fluid Technology Co. Ltd. |