CN105853736A - Traditional Chinese medicinal composition for treating wind-heat cold type bovine epidemic fever and preparation method of traditional Chinese medicinal composition - Google Patents

Traditional Chinese medicinal composition for treating wind-heat cold type bovine epidemic fever and preparation method of traditional Chinese medicinal composition Download PDF

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CN105853736A
CN105853736A CN201610307039.7A CN201610307039A CN105853736A CN 105853736 A CN105853736 A CN 105853736A CN 201610307039 A CN201610307039 A CN 201610307039A CN 105853736 A CN105853736 A CN 105853736A
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herba
traditional chinese
chinese medicinal
medicinal composition
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傅建功
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Yantai Minwang Electromechanical Technology Co Ltd
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Yantai Minwang Electromechanical Technology Co Ltd
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Abstract

The invention discloses a traditional Chinese medicinal composition for treating wind-heat cold type bovine epidemic fever and a preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition comprises Rorippa Indica, Dracocephalum Rupestre, dandelions, butterflybush flowers, Aeschynomene Indica, Radix Asparagi, Radix Polygonati Officinalis, Bulbophyllum Odoratissimum, mirabilitum, Angelica Sinensis, Serissa Serissoides, Zornia Gibbosa, Wisteria Venusta, Filipendula Palmata, Kyllinga Monocephala, Elatostema Ichangense, Fructus Arctii, Primula Sieboldii and ginkgoes. The traditional Chinese medicinal composition has the advantages that the traditional Chinese medicinal composition treats the wind-heat cold type bovine epidemic fever and has the effect of dispelling wind, clearing heat, moistening dryness, soothing channels, relieving symptoms, diffusing the lung and relieving cough; through scientific body conditioning, good effect, quick action and less proneness to relapse are achieved; toxic and side effect is avoided, and growth of cattle is promoted.

Description

A kind of pharmaceutical composition treating affection due to external wind and heat type Bovine Ephemeral Fever and preparation method thereof
Technical field
The present invention relates to herbal medicine pharmaceutical technology field, particularly to a kind of pharmaceutical composition treating affection due to external wind and heat type Bovine Ephemeral Fever and preparation method thereof.
Background technology
Bovine Ephemeral Fever is by bovine epizootic fever virus, has another name called bovine ephemeral fever virus, a kind of acute febrile infectious disease caused.It is characterized by the highest heat, tachypnea, shed tears and Alimentary serious mucositis inflammation and the dyskinesia.The sick cattle of major part infecting this disease i.e. recovered normal through 2 days～3 days, therefore also known as Ephemeral fever or temporarily hot.This disease patient's condition is swift and violent, but mostly is optimum process.This disease is mistakenly considered influenza by past attempts.This condition of disease causes Niu great Qun to fall ill, hence it is evident that reduce the milk production of milk cattle.
Disease pathogen: bovine epizootic fever virus is sub-thread minus-stranded rna virus, belongs to Rhabdoviridae, and ephemeral fever virus belongs to.Japan separates the size average out to 140nm × 80nm of poison.The nucleic acid of virus is RNA type, to chloroform, ether sensitivity.Pyrogenic stage virus is present in the blood of disease cattle, respiratory secretions and feces.
During Separation of Bovine epizootic fever virus, being advisable with cow blood poison intracranial inoculation, suitably inoculation animal is nascent neonatal rat or hamster, when carrying out intracranial inoculation, may separate out virus.Musization virus can also grow on BEK, calf kidney and testicular cell, and BEK cell can be caused to produce pathological change.
Symptom: incubation period is 3 days～7 days.At the beginning of disease, ill domestic animal trembles, shivering, and then body temperature is increased to more than 40 DEG C, and after delaying 2 days～3 days, temperature recovery is normal.While body temperature raises, it is seen that shed tears, have water sample eye secretion, eyelid, conjunctival congestion, edema.Tachypnea, frequency of respiration is per minute up to more than 80 times, and dyspnea is suffered from poultry and emitted moans, in depressed shape.This is owing to there occurs interstitial emphysema, sometimes can be died by being choked to death.Appetite is useless absolutely, ruminates stopping.First stomach is wriggled and is stopped, and tympanites occurs or lacks moisture, and gastric content dries up.Feces is dried, sometimes dysentery.Extremities joint edema pain, sick cattle is slow-witted vertical, walks lamely, later dysstasia and lie prostrate.Pi Wen is the most whole, and particularly angle root, earflap, acra has creeping chill.It addition, visible subcutaneous emphysema under jaw.Stream nose liquid, stomatitis, significantly flows birth.Bicker has foam.Hypourocrinia, Cloudy Urine.Can miscarry when cow in calf is ill, stillborn fetus.Breast amount declines or lactogenic stops.This disease major part is optimum process, and case fatality rate is typically below 1%, and some cases for a long time because of extremities joint pain can not stand up and be eliminated.
Bovine Ephemeral Fever is divided into by Chinese medical discrimination: affection due to external wind and heat type: disease sees heating weight, and severe cold is light, and cough, dry mouth and tougue, color is micro-red, yellow and thin fur, floating and rapid pulse；Warm is at pulmonary type: disease sees the not aversion to cold that generates heat, rapid breathing, and dyspnea with rapid respiration of coughing, mouth color is scarlet, dry, rough and yellow fur, full and rapid pulse；Affection of exogenous wind-cold damp type: disease sees aversion to cold high fever, skin is lossless, and stiffness of the nape of having a headache, thirst and liking drink, extremities joint is walked lamely for a long time because of mild swelling and pain.
Western medical treatment is the most only cured the symptoms, not the disease, and cattle itself is caused certain injury by Western medicine, is unfavorable for the growth of cattle, and therefore, Chinese medicine has certain advantage.
Summary of the invention
In order to solve the problems referred to above, the invention provides a kind of pharmaceutical composition treating affection due to external wind and heat type Bovine Ephemeral Fever and preparation method thereof.
nullIn order to realize foregoing invention purpose，The invention provides a kind of pharmaceutical composition treating affection due to external wind and heat type Bovine Ephemeral Fever，Wherein，Prepared by the raw medicinal material of following mass fraction: dish 10-20 weight portion、Herba Dracocephali Rupestris's 15-20 weight portion、Wood flower 2-4 weight portion、Herba Taraxaci 6-10 weight portion、Flos Buddlejae 10-15 weight portion、Herba Aeschynonenes Indicae 8-15 weight portion、Radix Asparagi 10-15 weight portion、Rhizoma Polygonati Odorati 15-20 weight portion、Herba Bulbophylli Odoratissim 8-15 weight portion、Mirabilitum 3-5 weight portion、Radix Angelicae Sinensis 8-15 weight portion、Radix Serissae 8-15 weight portion、Herba Zornia Diphyllae 10-20 weight portion、Rsdix Wisterinae Venustae 15-20 weight portion、Stone perfume (or spice) 15-20 weight portion、Herba Kylligac coloratae 10-20 weight portion、Herba Caryopteridis Terniflorae 8-15 weight portion、Fructus Arctii 6-12 weight portion、Radix Primulae sieboldii 10-15 weight portion and Semen Ginkgo 2-4 weight portion.
Wherein, the raw medicinal material having following mass fraction prepares: dish 15 weight portion, Herba Dracocephali Rupestris 18 weight portion, wood spend 3 weight portions, Herba Taraxaci 8 weight portion, Flos Buddlejae 12 weight portion, Herba Aeschynonenes Indicae 12 weight portion, Radix Asparagi 12 weight portion, Rhizoma Polygonati Odorati 16 weight portion, Herba Bulbophylli Odoratissim 12 weight portion, Mirabilitum 4 weight portion, Radix Angelicae Sinensis 12 weight portion, Radix Serissae 12 weight portion, Herba Zornia Diphyllae 15 weight portion, Rsdix Wisterinae Venustae 17 weight portion, Shi Xiang 18 weight portion, Herba Kylligac coloratae 16 weight portion, Herba Caryopteridis Terniflorae 12 weight portion, Fructus Arctii 8 weight portion, Radix Primulae sieboldii 12 weight portion and Semen Ginkgo 3 weight portion.
In order to achieve the above object, the preparation method of the pharmaceutical composition that present invention also offers described treatment affection due to external wind and heat type Bovine Ephemeral Fever comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 85%～95% relative to mixture 4～6 times, it is heated to boiling reflux 2～4 hours, filter, use percolation with per minute 1～2ml speed slowly percolation, collect percolate, when being evaporated to 55～60 DEG C subsequently under vacuum 0.08～0.09Mpa, relative density is the mastic of 1.04～1.12, it is spray-dried, the inlet temperature 165 of spray dryer～175 DEG C, leaving air temp 80～85 DEG C, it is ground into powder subsequently, makes dried cream powder；
Step 2: add relative to dried cream powder quality 0.1～the cane sugar powder of 0.3 times and the dextrin of 0.1～0.2 times in the dried cream powder obtained, make granule, is dried in 45～50 DEG C, it is thus achieved that granule.
Or preparation method comprises the following steps:
Step 1: by Radix Asparagi, Rhizoma Polygonati Odorati and Herba Bulbophylli Odoratissim grind into powder；Step 2: take surplus stock medical material again and add 85-95% soak with ethanol 0.5-1.5 hour of 2-4 times amount, heating extraction 1-2 time, 0.5-1.5 hour every time, filter to obtain extracting solution, united extraction liquid, the ultrafiltration post ultrafiltration that molecular weight is 38000-84000 through damming again, ultrafiltration decompression removes ethanol, concentrating as relative density when 85-95 DEG C is the extractum of 1.03, becomes component 1；Step 3: the medicinal residues that step 2 obtains add 2-3 times amount water soaking 1.0-2.0 hour, extracts 1 time for 1.0-1.5 hour, and being concentrated by extracting solution heating under reduced pressure as relative density when 80-90 DEG C is the extractum of 1.1, as component 2;Step 4: mixed by the powder that component 1, component 2 obtain with step 1, adds and is twisted into honey refining pill relative to the Mel of mixture 2 times amount.
The invention has the beneficial effects as follows: the pharmaceutical composition of the present invention, treatment affection due to external wind and heat type Bovine Ephemeral Fever, there is wind and heat dispersing, Hua Shui moisturizes, relax through inducing sweat and effect of lung qi dispersing cough-relieving, by the science of matrix is nursed one's health, effective, curative effect is fast, is difficult to recurrence, and have no side effect, and promote the growth of cattle.
Detailed description of the invention
The present invention provides a kind of pharmaceutical composition treating affection due to external wind and heat type Bovine Ephemeral Fever, wherein, including following raw medicinal material: dish, Herba Dracocephali Rupestris, wood flower, Herba Taraxaci, Flos Buddlejae, Herba Aeschynonenes Indicae, Radix Asparagi, Rhizoma Polygonati Odorati, Herba Bulbophylli Odoratissim, Mirabilitum, Radix Angelicae Sinensis, Radix Serissae, Herba Zornia Diphyllae, Rsdix Wisterinae Venustae, Shi Xiang, Herba Kylligac coloratae, Herba Caryopteridis Terniflorae, Fructus Arctii, Radix Primulae sieboldii and Semen Ginkgo.Ingredients scientific matching, reaches to treat the purpose of affection due to external wind and heat type Bovine Ephemeral Fever, has preferable effect.
The pharmacology of various raw medicinal materials is as follows:
Dish: [nature and flavor] are pungent, cool.1. supplement to the Herbal: " acrid in the mouth, temperature, nontoxic." 2. " Kweiyang medicinal herbs among the people ": " is pungent, cool, nontoxic." 3. " Traditional Chinese Medicine in Sichuan will ": " is cool in nature.Bitter in the mouth is pungent, nontoxic." 4. Guangzhou army " conventional Chinese herbal medicine handbook ": " is sweet light, cool." [function cures mainly] heat clearing away, diuresis, invigorate blood circulation, stimulate the menstrual flow.Curing cold, heat syndrome cough, pharyngalgia, measles is difficult to send out, rheumatic arthritis, jaundice, edema, and furuncle swells, amenorrhea, traumatic injury.1. supplement to the Herbal: " removing cold air, tremble with fear for a long time in abdomen, diet does not disappears, and makes us eating." 2. " detailed outline ": " profit chest and diaphragm, slit cold phlegm, cardiac and abdominal pain." 3. " classifying herbal ": " is controlled cutter and cuts axe wound, rotten skin ulcer, granulation promoting, chews painting." 4. " south of the Five Ridges gather medicinal herbs record ": " and raw fish are decocted soup and take it, the heat in boning." 5. " Guizhou side among the people medicine collection ": " antipyretic diuresis.Control ascites, drench disease；Burn is controlled in external.Furunculosis is controlled in " 6. " conventional glossary of Herbs and Drugs among the people ": " external；Venting QI-blood for oral administration.Control women's breast sick, and control cough, jaundice." 7. " Kweiyang medicinal herbs among the people ": " heat-clearing and toxic substances removing, relieving cough and resolving phlegm.Dermatitis rhus, furuncle, carbuncle are controlled in external." 8. Guangzhou army " conventional Chinese herbal medicine handbook ": " clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Cure cold heating, laryngopharynx swelling and pain, aphonia；Cough due to lung-heat, hemoptysis；Acute rheumatic arthritis；Edema." 9. " Fujian Chinese herbal medicine ": " dispelling wind expelling pathogenic factors from the exterior, regulating qi-flowing for harmonizing stomach."
Herba Dracocephali Rupestris: [nature and flavor] acrid in the mouth；Bitter；Cool in nature.[function cures mainly] wind and heat dispersing；Cool liver is stopped blooding.Main anemopyretic cold；Headache；Laryngopharynx swelling and pain；Cough；Jaundice；Dysentery；Spit blood；Epistaxis.
Wood flower: nature and flavor are pungent is flat.1. supplement to the Herbal: " pungent, flat." 2. " vegetation just side ": " is bitter, is slightly cold." 3. " Kweiyang medicinal herbs among the people ": " is sweet, cold, nontoxic." [function cures mainly] wind-damp dispelling, diuresis, dissipating blood stasis blood, detumescence poison.Treating rheumatic arthritis, oedema due to nephritis, cirrhotic ascites, acute, chronic hepatitis, stomachache, stranguria with turbid discharge, metrorrhagia, traumatic injury, scrofula, carbuncle.
Herba Taraxaci: [nature and flavor] are bitter, sweet, cold.[return through] returns liver, stomach warp.[function cures mainly] heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Flos Buddlejae: [nature and flavor] are sweet, are slightly cold.[return through] returns Liver Channel.[function cures mainly] heat clearing away nourishing the liver, improving acuity of vision and removing nebula.For conjunctival congestion and swelling pain, many tear photophobia, nebula of looking unfamiliar film, hepatasthenia dim eyesight, blurring of vision.
Herba Aeschynonenes Indicae: [nature and flavor] are sweet light, cold.1. (Bencao Shiyi ": " sweet in the mouth, cold, nontoxic." 2. " Tian Bao book on Chinese herbal medicine ": " bitter in the mouth dilture acid." 3. " Traditional Chinese Medicine in Sichuan will ": " is cool in nature, and puckery is nontoxic." 4. " Chinese herbal medicine is commonly used in Shanghai ": " is bitter, flat." wind, dampness removing, detumescence, removing toxic substances are gone in [function cures mainly] heat clearing away.Control anemopyretic cold, jaundice, dysentery, gastritis, abdominal distention, gonorrhea, carbuncle, dermatitis, eczema.
Radix Asparagi: [nature and flavor] sweetness and bitterness, cold.1. " herbal classic ": " bitter in the mouth is flat." 2. " not Lu ": " be sweet, Great Cold, nontoxic." 3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " is cold in nature, sweet and slightly bitter taste." [return through] enters lung, kidney channel.1. Materia Medica of Decoction: " lunar, meridian of Foot-SHAO YIN of starting with." 2. " book on Chinese herbal medicine is through solving ": " enters lung meridian, heart channel of Hand-Shaoyin." [function cures mainly] YIN nourishing, moisturizes, lung heat clearing, pathogenic fire reducing.Controlling fever due to yin deficiency, cough is spitted blood, consumptive lung disease, lung abscess, and laryngopharynx swelling and pain is quenched one's thirst, constipation.
Rhizoma Polygonati Odorati: [nature and flavor] are sweet, are slightly cold.[return through] attaches to the lung and stomach meridians.[function cures mainly] nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.Hindering for lung stomach-Yin, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst.
Herba Bulbophylli Odoratissim: [nature and flavor] are sweet light, cool.1. " Kunming conventional medical herbs among the people ": " taste is micro-sour and astringent, and property is put down." 2. " choosing of Yunnan Chinese herbal medicine ": " is sweet light, cool." [function cures mainly] moistening the lung and resolving phlegm, promoting the circulation of QI to relieve pain.Control pulmonary tuberculosis, spitting of blood, chronic tracheitis, chronic pharyngitis, hernia pain, menoxenia, fracture.1. " Kunming conventional medical herbs among the people ": " wind-damp dispelling, active, circulation of qi promoting, pain relieving." 2. " choosing of Yunnan Chinese herbal medicine ": " synthetism antiinflammatory, moistening the lung and resolving phlegm.Control fracture, pulmonary tuberculosis, spitting of blood, chronic tracheitis, pneumonia convalescent period, chronic pharyngitis, menoxenia." 3. " catalogue planted by Guizhou medicine ": " clearing heat and moistening dryness, promoting the production of body fluid to quench thirst."
Mirabilitum: [nature and flavor] are arduous salty, cold.1. " herbal classic ": " bitter in the mouth, cold." 2. " not Lu ": " be pungent, Great Cold, nontoxic." 3. " property of medicine opinion ": " bitter in the mouth is salty." [return through] enters stomach, large intestine channel.1. " book on Chinese herbal medicine is looked for the truth ": " enter intestinal, stomach, double enter kidney." 2. " book on Chinese herbal medicine brief points ": " starts with, lunar, the Yangming Channel of foot." [function cures mainly] purges heat, and moisturizes, softening the hard mass.Controlling excess-heat to stagnate, abdominal distention constipation, retention of phlegm gathers, conjunctival congestion and swelling pain, sore throat, carbuncle.
Radix Angelicae Sinensis: [nature and flavor] sweet, acrid, warm [return through] returns liver, the heart, spleen channel.[function cures mainly] replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Radix Serissae: [nature and flavor] toil is cool.1. supplement to the Herbal: " nontoxic." 2. " the SHENGCAO property of medicine is standby to be wanted ": " bitter in the mouth, cold in nature." 3. " Guizhou folk medicine ": " is cool in nature, and taste is micro-pungent." [function cures mainly] dispels the wind, dampness removing, heat clearing away, removing toxic substances.Dispelling the wind and dampness pathogens lumbago and skelalgia, dysentery, edema, conjunctival congestion and swelling pain, laryngalgia, toothache, women leucorrhea, carbuncle, scrofula.
Herba Zornia Diphyllae: [nature and flavor] are sweet, light, cool.[function cures mainly] heat-clearing and toxic substances removing, removing pathogenic heat from blood and toxic substance from the body.For catching a cold, pharyngolaryngitis, acute icterohepatitis, acute gastroenteritis, acute appendicitis, infantile malnutrition, acute mastitis, eye keratitis；Traumatic injury, carbuncle furuncle and phyma poison, venom are controlled in external.
Rsdix Wisterinae Venustae: [nature and flavor] are bitter, pungent, heat.Poisonous.[function cures mainly] relieving the exterior syndrome by diaphoresis, expelling wind and removing dampness.Catch a cold lossless, have a headache, have a stuffy nose, rheumatalgia, traumatic injury.
Shi Xiang: [nature and flavor] work hard, temperature.1. " Kai Baoben gill fungus ": " acrid in the mouth is fragrant, temperature, nontoxic." 2. " Zhejiang conventional medical herbs among the people ": " slightly warm in nature, acrid in the mouth." [function cures mainly] drives away summer heat, and invigorates blood circulation, and regulates the flow of vital energy, removing dampness.Controlling Xia Yue flu, heatstroke vomiting and nausea, stomachache is had loose bowels, traumatic injury stasis of blood pain, eczema, furuncle and phyma.1. " Kaibao Bencao ": " stomach warming in homophony, only cholera is vomited and diarrhoea, trusted subordinate's distension, periumbilical pain, borborygmus." 2. Guangzhou army " conventional Chinese herbal medicine handbook ": " antidotes against snake bite, and turbid expelling summer-heat is changed in dissipating blood stasis analgesic therapy.Controlling venom, traumatic injury stasis of blood pain, heatstroke is generated heat, skin eczema pruritus, multiple furuncle and phyma." 3. " Jiangxi medical herbs ": " is driven away summer heat and is regulated the flow of vital energy.Controlling the Infantile Summer Fever initial stage, heatstroke is felt sick." 4. " Zhejiang conventional medical herbs among the people ": " circulation of qi promoting of driving away summer heat, induces sweat, pain relieving.Control heatstroke, flu, stomachache."
Herba Kylligac coloratae: [nature and flavor] micro-hardship sweet, micro-is flat.[function cures mainly] removing heat-phlegm, promoting blood circulation and detumescence.Cure mainly pertussis, malaria；Traumatic injury, snake bite and insect sting are controlled in external.
Herba Caryopteridis Terniflorae: [nature and flavor] are pungent, temperature.[function cures mainly] delivers cold expelling, lung qi dispersing cough-relieving, promoting blood flow to regulate menstruation.For cold cough, chronic bronchitis, pertussis, stimulate the menstrual flow, puerperal abdonimal pain；Knife injury, burn and scald, venom are controlled in external.
Fructus Arctii: [nature and flavor] are pungent, bitter, cold.[return through] attaches to the lung and stomach meridians.[function cures mainly] dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.For anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, mumps erysipelas, carbuncle sore tumefacting virus.
Radix Primulae sieboldii: [nature and flavor] " Ningxia Chinese herbal medicine handbook ": " sweet, flat." [function cures mainly] " Jilin Chinese herbal medicine ": " relieving cough and resolving phlegm.Control phlegm dyspnea cough."
Semen Ginkgo: [nature and flavor] sweetness and bitterness is puckery, flat.1. principle of Correct Diet: " sweet-bitter flavor is nontoxic." 2. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " sweet in the mouth, flat, cold in nature." 3. " detailed outline ": " sweetness and bitterness, flat, puckery.The little hardship of " " prepared food is micro-sweet, warm in nature, slightly poisonous." [return through] enters lung, kidney channel.1. " detailed outline ": " enter lung meridian." 2. " book on Chinese herbal medicine converges and says ": " yang channel lunar, big of starting with." 3. " book on Chinese herbal medicine is the newest ": " enters the heart, lung, kidney three warp." [function cures mainly] astringes the lung gas, and relieving asthma and cough, leukorrhagia stopping is turbid, urine reducing.Control asthma, phlegmatic cough, leucorrhea, nebulousurine, seminal emission, gonorrhea, frequent micturition.
Currently preferred only above raw medicinal material prepares.
Hereinafter using embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1 decoction
Proportioning: dish 10g, Herba Dracocephali Rupestris 15g, wood flower 2g, Herba Taraxaci 6g, Flos Buddlejae 10g, Herba Aeschynonenes Indicae 8g, Radix Asparagi 10g, Rhizoma Polygonati Odorati 15g, Herba Bulbophylli Odoratissim 8g, Mirabilitum 3g, Radix Angelicae Sinensis 8g, Radix Serissae 8g, Herba Zornia Diphyllae 10g, Rsdix Wisterinae Venustae 15g, Shi Xiang 15g, Herba Kylligac coloratae 10g, Herba Caryopteridis Terniflorae 8g, Fructus Arctii 6g, Radix Primulae sieboldii 10g and Semen Ginkgo 2g.
Its preparation method is:
Step one: the mixing of described raw medicinal material is put in purple casserole, adds clear water, to clear water dipped medical material upper surface 3cm, soak 4 hours；
Step 2: be placed on fire by purple casserole, after intense fire boils, using slow fire instead and decocting the 40 minutes dosage to medicinal liquid slowly is 250ml, filters, obtains filtrate a, standby；
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 4cm, soaks 5 hours；
Step 4: be placed on fire by purple casserole, after intense fire boils, using slow fire instead and decocting the 30 minutes dosage to medicinal liquid slowly is 250ml, filters, obtains filtrate b, is mixed by filtrate a and filtrate b and i.e. can get decoction.
Embodiment 2 granule
Proportioning: dish 20g, Herba Dracocephali Rupestris 20g, wood flower 4g, Herba Taraxaci 10g, Flos Buddlejae 15g, Herba Aeschynonenes Indicae 15g, Radix Asparagi 15g, Rhizoma Polygonati Odorati 20g, Herba Bulbophylli Odoratissim 15g, Mirabilitum 5g, Radix Angelicae Sinensis 15g, Radix Serissae 15g, Herba Zornia Diphyllae 20g, Rsdix Wisterinae Venustae 20g, Shi Xiang 20g, Herba Kylligac coloratae 20g, Herba Caryopteridis Terniflorae 15g, Fructus Arctii 12g, Radix Primulae sieboldii 15g and Semen Ginkgo 4g.
Its preparation method is:
Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 85% relative to 4 times of mixture, it is heated to boiling reflux 4 hours, filters, use percolation with the speed slowly percolation of 2ml per minute, collect percolate, being evaporated to relative density when 55 DEG C subsequently under vacuum 0.08Mpa is the mastic of 1.1, is spray-dried, the inlet temperature of spray dryer 170 DEG C, leaving air temp 80 DEG C, it is ground into powder subsequently, makes dried cream powder；
Step 2: add the cane sugar powder relative to dried cream powder quality 0.2 times and the dextrin of 0.2 times in the dried cream powder obtained, make granule, is dried in 50 DEG C, it is thus achieved that granule.
Embodiment 3 honey refining pill
Proportioning: dish 15g, Herba Dracocephali Rupestris 18g, wood flower 3g, Herba Taraxaci 8g, Flos Buddlejae 12g, Herba Aeschynonenes Indicae 12g, Radix Asparagi 12g, Rhizoma Polygonati Odorati 16g, Herba Bulbophylli Odoratissim 12g, Mirabilitum 4g, Radix Angelicae Sinensis 12g, Radix Serissae 12g, Herba Zornia Diphyllae 15g, Rsdix Wisterinae Venustae 17g, Shi Xiang 18g, Herba Kylligac coloratae 16g, Herba Caryopteridis Terniflorae 12g, Fructus Arctii 8g, Radix Primulae sieboldii 12g and Semen Ginkgo 3g.
Its preparation method is:
Step 1: by Radix Asparagi, Rhizoma Polygonati Odorati and Herba Bulbophylli Odoratissim grind into powder；Step 2: take surplus stock medical material again and add 90% soak with ethanol 1 hour of 4 times amount, heating extraction 2 times, each 1 hour, filter to obtain extracting solution, united extraction liquid, the ultrafiltration post ultrafiltration that molecular weight is 54000 through damming again, ultrafiltration decompression removes ethanol, when concentration is 85 DEG C, relative density is the extractum of 1.03, becomes component 1；Step 3: the medicinal residues that step 2 obtains add 2 times amount water soaking 2 hours, extracts 1 time for 1 hour, and when being 85 DEG C by the concentration of extracting solution heating under reduced pressure, relative density is the extractum of 1.1, as component 2;Step 4: mixed by the powder that component 1, component 2 obtain with step 1, adds and is twisted into honey refining pill relative to the Mel of mixture 2 times amount.
The toxicity test of medicine
1. acute toxicity test: with the pharmaceutical composition of the embodiment of the present invention 1 as object, 150 times of clinical consumption per day are offerd medicine to the big enteral of white mouse, are observed 7.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.White mouse vagina and damaged skin are carried out irritation test, there are no irritative response and other untoward reaction.Toxicity test proves, the present invention does not has toxic action and untoward reaction, and clinical practice is safe and reliable.
2. long term toxicity test: mice is pressed 15,30 and 45g crude drugs/kg continuous use 16 weeks (1.0ml/100g body weight by the pharmaceutical composition of the embodiment of the present invention 2, every day 2 times) and drug withdrawal 4 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by medicine of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 16 weeks and drug withdrawal 4 weeks, Organs of Mice is all without substantially changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
Contrast test
Vaccary, Liaocheng cultivation cattle about 1000, has 200 cattle the symptom of affection due to external wind and heat type Bovine Ephemeral Fever occur: disease sees heating weight, and severe cold is light, and cough, dry mouth and tougue, color is micro-red, yellow and thin fur, floating and rapid pulse.
Select 200 ill cattle, isolation cultivation, and be randomly divided into four groups, embodiment 1 group, embodiment 2 groups, embodiment 3 groups and matched group, often group 50.
Embodiment 1 group uses the pharmaceutical composition decoction of the embodiment of the present invention 1 to treat, and is mixed in conventional feed according to the ratio of 4:100 by decoction, normally feeds, carries out 2.
Embodiment 2 groups uses the medicament composition granule agent of the embodiment of the present invention 2 to treat, and is mixed in conventional feed according to the ratio of 4:100 by granule, normally feeds, carries out 2.
Embodiment 3 groups uses the pharmaceutical composition honey refining pill of the embodiment of the present invention 3 to treat, and honey refines pill and is mixed in conventional feed according to the ratio of 4:100, normally feed, carry out 2.
Matched group: use with penicillin, streptomycin, and with medicines such as G/NS, ringer's solution, caffeine and sodium benzoate, vitamin B1 and vitamin Cs, intravenous injection, every day 2 times, conventional feed normally feeds, and carries out 2.
The treatment situation of record experimentation.See table 1.
The average weight of the cattle before and after record experiment, calculates average weight growth pattern.See table 2.
Table 1 is treatment situation contrast (often organizing 50 altogether) of each group
See table 1 can be seen that, healing number and the cure rate of the treatment cattle of embodiment 1 group, embodiment 2 groups and embodiment 3 groups will be higher than the healing number of the cattle of matched group and cure rates, it is appreciated that, the pharmaceutical composition of the present invention, on treatment affection due to external wind and heat type Bovine Ephemeral Fever, therapeutic effect is good, determined curative effect, well improves the state of an illness.
Table 2 is the balanced growth body weight contrast of the cattle of each group
Group Sum Average weight before experiment Average weight after test Average daily gain
Embodiment group 1 50 532.0kg 535.44kg 1.72kg/d
Embodiment group 2 50 531.2kg 534.88kg 1.84kg/d
Embodiment group 2 50 530.1kg 533.76kg 1.83kg/d
Matched group 50 532.1kg 533.54kg 0.72kg/d
See table 2 it can be seen that while the treatment affection due to external wind and heat type Bovine Ephemeral Fever of embodiment 1 group, embodiment 2 groups and embodiment 3 groups, growth rate will be faster than matched group, maintains the normal growth of cattle.
In sum, pharmaceutical composition of the present invention, on treatment affection due to external wind and heat type Bovine Ephemeral Fever, therapeutic effect is good, determined curative effect, and ensure that the normal growth of cattle.
Citing: Dezhou City vaccary cowboying 700, in JIUYUE, 2014,200 there is affection due to external wind and heat type Bovine Ephemeral Fever symptom: disease sees heating weight, and severe cold is light, and cough, dry mouth and tougue, color is micro-red, yellow and thin fur, floating and rapid pulse.Select 100 ill cattle to carry out isolation treatment, use the medicament composition granule agent of the embodiment of the present invention 2 to treat, granule is mixed in conventional feed according to the ratio of 4:100, normally feeds, carry out 2.Cure for 100, cure rate 100%.Body weight increases 3.4kg during treating.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.

Claims (4)

  1. null1. the pharmaceutical composition treating affection due to external wind and heat type Bovine Ephemeral Fever，It is characterized in that，Prepared by the raw medicinal material of following mass fraction: dish 10-20 weight portion、Herba Dracocephali Rupestris's 15-20 weight portion、Wood flower 2-4 weight portion、Herba Taraxaci 6-10 weight portion、Flos Buddlejae 10-15 weight portion、Herba Aeschynonenes Indicae 8-15 weight portion、Radix Asparagi 10-15 weight portion、Rhizoma Polygonati Odorati 15-20 weight portion、Herba Bulbophylli Odoratissim 8-15 weight portion、Mirabilitum 3-5 weight portion、Radix Angelicae Sinensis 8-15 weight portion、Radix Serissae 8-15 weight portion、Herba Zornia Diphyllae 10-20 weight portion、Rsdix Wisterinae Venustae 15-20 weight portion、Stone perfume (or spice) 15-20 weight portion、Herba Kylligac coloratae 10-20 weight portion、Herba Caryopteridis Terniflorae 8-15 weight portion、Fructus Arctii 6-12 weight portion、Radix Primulae sieboldii 10-15 weight portion and Semen Ginkgo 2-4 weight portion.
  2. The pharmaceutical composition for the treatment of affection due to external wind and heat type Bovine Ephemeral Fever the most according to claim 1, it is characterized in that, the raw medicinal material having following mass fraction prepares: dish 15 weight portion, Herba Dracocephali Rupestris 18 weight portion, 3 weight portions spent by wood, Herba Taraxaci 8 weight portion, Flos Buddlejae 12 weight portion, Herba Aeschynonenes Indicae 12 weight portion, Radix Asparagi 12 weight portion, Rhizoma Polygonati Odorati 16 weight portion, Herba Bulbophylli Odoratissim 12 weight portion, Mirabilitum 4 weight portion, Radix Angelicae Sinensis 12 weight portion, Radix Serissae 12 weight portion, Herba Zornia Diphyllae 15 weight portion, Rsdix Wisterinae Venustae 17 weight portion, fragrant 18 weight portions of stone, Herba Kylligac coloratae 16 weight portion, Herba Caryopteridis Terniflorae 12 weight portion, Fructus Arctii 8 weight portion, Radix Primulae sieboldii 12 weight portion and Semen Ginkgo 3 weight portion.
  3. The pharmaceutical composition for the treatment of affection due to external wind and heat type Bovine Ephemeral Fever the most according to claim 1 and 2, it is characterised in that its preparation method comprises the following steps:
    Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 85%～95% relative to mixture 4～6 times, it is heated to boiling reflux 2～4 hours, filter, use percolation with per minute 1～2ml speed slowly percolation, collect percolate, when being evaporated to 55～60 DEG C subsequently under vacuum 0.08～0.09Mpa, relative density is the mastic of 1.04～1.12, it is spray-dried, the inlet temperature 165 of spray dryer～175 DEG C, leaving air temp 80～85 DEG C, it is ground into powder subsequently, makes dried cream powder；
    Step 2: add relative to dried cream powder quality 0.1～the cane sugar powder of 0.3 times and the dextrin of 0.1～0.2 times in the dried cream powder obtained, make granule, is dried in 45～50 DEG C, it is thus achieved that granule.
  4. 4. the preparation method of the pharmaceutical composition of the treatment affection due to external wind and heat type Bovine Ephemeral Fever described in an any one of claims 1 to 3, it is characterised in that comprise the following steps:
    Step 1: by Radix Asparagi, Rhizoma Polygonati Odorati and Herba Bulbophylli Odoratissim grind into powder；Step 2: take surplus stock medical material again and add 85-95% soak with ethanol 0.5-1.5 hour of 2-4 times amount, heating extraction 1-2 time, 0.5-1.5 hour every time, filter to obtain extracting solution, united extraction liquid, the ultrafiltration post ultrafiltration that molecular weight is 38000-84000 through damming again, ultrafiltration decompression removes ethanol, concentrating as relative density when 85-95 DEG C is the extractum of 1.03, becomes component 1；Step 3: the medicinal residues that step 2 obtains add 2-3 times amount water soaking 1.0-2.0 hour, extracts 1 time for 1.0-1.5 hour, and being concentrated by extracting solution heating under reduced pressure as relative density when 80-90 DEG C is the extractum of 1.1, as component 2;Step 4: mixed by the powder that component 1, component 2 obtain with step 1, adds and is twisted into honey refining pill relative to the Mel of mixture 2 times amount.
CN201610307039.7A 2016-05-11 2016-05-11 Traditional Chinese medicinal composition for treating wind-heat cold type bovine epidemic fever and preparation method of traditional Chinese medicinal composition Withdrawn CN105853736A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103860941A (en) * 2014-04-01 2014-06-18 李佃场 Traditional Chinese medicine for treating schizophrenia and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103860941A (en) * 2014-04-01 2014-06-18 李佃场 Traditional Chinese medicine for treating schizophrenia and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
郑继方等: "《奶牛常见病综合防治技术》", 31 March 2010, 金盾出版社 *

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Application publication date: 20160817