CN105832939A - 一种用于治疗猪腹泻的植物复方药剂及其制备方法 - Google Patents

一种用于治疗猪腹泻的植物复方药剂及其制备方法 Download PDF

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CN105832939A
CN105832939A CN201610288114.XA CN201610288114A CN105832939A CN 105832939 A CN105832939 A CN 105832939A CN 201610288114 A CN201610288114 A CN 201610288114A CN 105832939 A CN105832939 A CN 105832939A
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何佑兵
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Abstract

本发明公开了一种用于治疗猪腹泻的植物复方药剂及其制备方法，用于治疗猪腹泻的植物复方药剂的原料包括黑面神、甘草、茯苓、川芎、广木香、上肉桂、北细辛、麻黄、生川乌、元参、黄柏、生草乌、酒曲、丹皮、当归、银杏叶、黄芪、半支莲、垂盆草、莱菔子、大青叶、槟榔、金樱子、板蓝根、马齿苋、黄连、蒲公英、金银花、白芍、花椒。本发明采用纯中草药配制而成，能有效杀灭引发猪流行性腹泻和猪传染性胃肠炎的病毒，尤其适用于抗生素治疗效果不明显的病例，能充分体现中医药的整体观念和优势，使药效和功能更为全面达到标本兼治，具有配方绿色环保、工艺简单合理、制作成本低、预防和治疗效果好、药副作用小的优点。

Description

一种用于治疗猪腹泻的植物复方药剂及其制备方法
技术领域
本发明涉及兽药制备技术领域，具体是一种用于治疗猪腹泻的植物复方药剂及其制备方法。
背景技术
猪腹泻占猪病总量的35-45％，严重损害猪只的健康。出现猪腹泻的疾病以细菌和病毒引起的传染性疾病为主，主要包括仔猪黄白痢、仔猪副伤寒、仔猪梭菌性肠炎、猪流行性腹泻、猪痢疾、猪传染性胃肠炎、轮状病毒病和猪增生性肠炎等，病猪主要表现为腹泻，同时或还伴有体温升高、精神不振、食欲减退、呕吐和脱水等症状。腹泻引起猪只生长缓慢，饲料报酬降低，生产性能下降，延长出栏时间，甚至引起猪只出现死亡，给养猪业造成巨大的经济损失。
目前对于猪腹泻的预防和治疗，主要采用抗生素进行预防和治疗，如庆大霉素、氟哌酸、恩诺沙星、阿莫西林、硫酸粘菌素、环丙沙星和氟苯尼考等，长期使用或滥用抗生素，容易引起机体免疫功能低下，破坏猪只的胃肠道微生态平衡，损害肠道健康，影响猪只对饲料中营养的吸收，严重威胁养猪业的可持续发展；导致细菌产生耐药性和猪肉及其制品中的抗生素残留严重超标，影响猪群疫病防控、猪肉制品安全和出口等，人们长期食用有抗生素残留的猪肉制品，易引起人过敏反应、毒性反应等，危害人们的身体健康。另外，由于金刚烷胺类等人用抗病毒药移植兽用，缺乏科学规范、安全有效实验数据，用于动物病毒性疫病给动物疫病控制带来不良后果，影响国家动物疫病防控政策的实施，因此禁止抗病毒药物在预防和治疗猪病的使用。所以，越来越多的抗生素和抗病毒药物禁止用于猪病治疗。综上所述，当前急需一种高效、无残留、无耐药和抗菌抗病毒的一种药物预防和治疗猪腹泻。
由于植物药来源天然，低残留或无残留，不易产生耐药性，具有抗菌抗病毒、清除肠道毒素和消除炎症等作用，对人体无害，引起了人们对中药的进行研究，致力于将植物药用于防治猪腹泻，促进无公害养猪。
发明内容
本发明的目的在于提供一种涩肠止泻、抗菌抗病毒的用于治疗猪腹泻的植物复方药剂及其制备方法，以解决上述背景技术中提出的问题。
为实现上述目的，本发明提供如下技术方案：
一种用于治疗猪腹泻的植物复方药剂，按照重量份的原料包括：黑面神60-80份、甘草8-12份、茯苓10-30份、川芎20-30份、广木香20-30份、上肉桂20-30份、北细辛15-35份、麻黄20-40份、生川乌15-35份、元参20-40份、黄柏20-40份、生草乌15-35份、酒曲30-50份、丹皮20-40份、当归15-25份、银杏叶10-30份、黄芪30-50份、半支莲10-20份、垂盆草10-20份、莱菔子10-20份、大青叶8-12份、槟榔8-12份、金樱子8-12份、板蓝根20-40份、马齿苋15-25份、黄连3-5份、蒲公英10-20份、金银花20-30份、白芍4-6份、花椒1-3份。
作为本发明进一步的方案：所述用于治疗猪腹泻的植物复方药剂，按照重量份的原料包括：黑面神65-75份、甘草9-11份、茯苓15-25份、川芎22-28份、广木香22-28份、上肉桂22-28份、北细辛20-30份、麻黄25-35份、生川乌20-30份、元参25-35份、黄柏25-35份、生草乌20-30份、酒曲35-45份、丹皮25-35份、当归18-22份、银杏叶15-25份、黄芪35-45份、半支莲12-18份、垂盆草12-18份、莱菔子12-18份、大青叶9-11份、槟榔9-11份、金樱子9-11份、板蓝根25-35份、马齿苋18-22份、黄连3.5-4.5份、蒲公英12-18份、金银花22-28份、白芍4.5-5.5份、花椒1.5-2.5份。
作为本发明再进一步的方案：所述用于治疗猪腹泻的植物复方药剂，按照重量份的原料包括：黑面神70份、甘草10份、茯苓20份、川芎25份、广木香25份、上肉桂25份、北细辛25份、麻黄30份、生川乌25份、元参30份、黄柏30份、生草乌25份、酒曲40份、丹皮30份、当归20份、银杏叶20份、黄芪40份、半支莲15份、垂盆草15份、莱菔子15份、大青叶10份、槟榔10份、金樱子10份、板蓝根30份、马齿苋20份、黄连4份、蒲公英15份、金银花25份、白芍5份、花椒2份。
所述用于治疗猪腹泻的植物复方药剂的制备方法，具体步骤如下：
(1)按照重量份称取各原料；
(2)将马齿苋、黄连、丹皮、元参和黄柏分别洗净后制成粗粉；
(3)取黑面神拣选、洗净、烘干后粉碎过80-120目筛得到黑面神粉末备用；
(4)将甘草、茯苓、川芎、广木香、当归和槟榔拣选、洗净、烘干，分别或混合后粉碎，再与步骤(2)得到的粗粉混合，用浓度为60-80％的乙醇浸泡2-3h，再用浓度为60-80％的乙醇加热回流2-6次，每次1-3h，合并回流液后过滤，将滤液回收乙醇后浓缩为温度45-55℃时相对密度为1.25-1.3的稠膏；
(5)将步骤(4)中的药渣与上肉桂、北细辛、麻黄、生川乌、生草乌、酒曲银杏叶、黄芪、半支莲、垂盆草、莱菔子、大青叶、金樱子、板蓝根、蒲公英、金银花、白芍和花椒合并后，加4-6倍的水煎煮2-3次，每次1.5-2.5h，合并煎煮液并过滤，将滤液浓缩为温度45-55℃时相对密度为1.25-1.3的稠膏；
(6)将步骤(4)和步骤(5)得到的稠膏混匀后，加入黑面神粉末，经混匀、制粒烘干后得到成品。
与现有技术相比，本发明的有益效果是：
本发明采用纯中草药配制而成，能有效杀灭引发猪流行性腹泻和猪传染性胃肠炎的病毒，无须使用其它一切抗菌药物，尤其适用于抗生素治疗效果不明显的病例，能充分体现中医药的整体观念和优势，使药效和功能更为全面达到标本兼治，具有配方绿色环保、工艺简单合理、制作成本低、预防和治疗效果好、药副作用小的优点。
具体实施方式
下面结合具体实施方式对本专利的技术方案作进一步详细地说明。
实施例1
一种用于治疗猪腹泻的植物复方药剂，按照重量份的原料包括：黑面神60份、甘草8份、茯苓10份、川芎20份、广木香20份、上肉桂20份、北细辛15份、麻黄20份、生川乌15份、元参20份、黄柏20份、生草乌15份、酒曲30份、丹皮20份、当归15份、银杏叶10份、黄芪30份、半支莲10份、垂盆草10份、莱菔子10份、大青叶8份、槟榔8份、金樱子8份、板蓝根20份、马齿苋15份、黄连3份、蒲公英10份、金银花20份、白芍4份、花椒1份。
所述用于治疗猪腹泻的植物复方药剂的制备方法，具体步骤如下：
(1)按照重量份称取各原料；
(2)将马齿苋、黄连、丹皮、元参和黄柏分别洗净后制成粗粉；
(3)取黑面神拣选、洗净、烘干后粉碎过80目筛得到黑面神粉末备用；
(4)将甘草、茯苓、川芎、广木香、当归和槟榔拣选、洗净、烘干，分别或混合后粉碎，再与步骤(2)得到的粗粉混合，用浓度为60％的乙醇浸泡2h，再用浓度为60％的乙醇加热回流2次，每次1h，合并回流液后过滤，将滤液回收乙醇后浓缩为温度45℃时相对密度为1.25的稠膏；
(5)将步骤(4)中的药渣与上肉桂、北细辛、麻黄、生川乌、生草乌、酒曲银杏叶、黄芪、半支莲、垂盆草、莱菔子、大青叶、金樱子、板蓝根、蒲公英、金银花、白芍和花椒合并后，加4倍的水煎煮2次，每次1.5h，合并煎煮液并过滤，将滤液浓缩为温度45℃时相对密度为1.25的稠膏；
(6)将步骤(4)和步骤(5)得到的稠膏混匀后，加入黑面神粉末，经混匀、制粒烘干后得到成品。
实施例2
一种用于治疗猪腹泻的植物复方药剂，按照重量份的原料包括：黑面神65份、甘草9份、茯苓15份、川芎22份、广木香22份、上肉桂22份、北细辛20份、麻黄25份、生川乌20份、元参25份、黄柏25份、生草乌20份、酒曲35份、丹皮25份、当归18份、银杏叶15份、黄芪35份、半支莲12份、垂盆草12份、莱菔子12份、大青叶9份、槟榔9份、金樱子9份、板蓝根25份、马齿苋18份、黄连3.5份、蒲公英12份、金银花22份、白芍4.5份、花椒1.5份。
所述用于治疗猪腹泻的植物复方药剂的制备方法，具体步骤如下：
(1)按照重量份称取各原料；
(2)将马齿苋、黄连、丹皮、元参和黄柏分别洗净后制成粗粉；
(3)取黑面神拣选、洗净、烘干后粉碎过90目筛得到黑面神粉末备用；
(4)将甘草、茯苓、川芎、广木香、当归和槟榔拣选、洗净、烘干，分别或混合后粉碎，再与步骤(2)得到的粗粉混合，用浓度为65％的乙醇浸泡2.2h，再用浓度为65％的乙醇加热回流3次，每次1.5h，合并回流液后过滤，将滤液回收乙醇后浓缩为温度45-55℃时相对密度为1.26的稠膏；
(5)将步骤(4)中的药渣与上肉桂、北细辛、麻黄、生川乌、生草乌、酒曲银杏叶、黄芪、半支莲、垂盆草、莱菔子、大青叶、金樱子、板蓝根、蒲公英、金银花、白芍和花椒合并后，加4.5倍的水煎煮2次，每次1.8h，合并煎煮液并过滤，将滤液浓缩为温度48℃时相对密度为1.26的稠膏；
(6)将步骤(4)和步骤(5)得到的稠膏混匀后，加入黑面神粉末，经混匀、制粒烘干后得到成品。
实施例3
一种用于治疗猪腹泻的植物复方药剂，按照重量份的原料包括：黑面神70份、甘草10份、茯苓20份、川芎25份、广木香25份、上肉桂25份、北细辛25份、麻黄30份、生川乌25份、元参30份、黄柏30份、生草乌25份、酒曲40份、丹皮30份、当归20份、银杏叶20份、黄芪40份、半支莲15份、垂盆草15份、莱菔子15份、大青叶10份、槟榔10份、金樱子10份、板蓝根30份、马齿苋20份、黄连4份、蒲公英15份、金银花25份、白芍5份、花椒2份。
所述用于治疗猪腹泻的植物复方药剂的制备方法，具体步骤如下：
(1)按照重量份称取各原料；
(2)将马齿苋、黄连、丹皮、元参和黄柏分别洗净后制成粗粉；
(3)取黑面神拣选、洗净、烘干后粉碎过100目筛得到黑面神粉末备用；
(4)将甘草、茯苓、川芎、广木香、当归和槟榔拣选、洗净、烘干，分别或混合后粉碎，再与步骤(2)得到的粗粉混合，用浓度为70％的乙醇浸泡2.5h，再用浓度为70％的乙醇加热回流4次，每次2h，合并回流液后过滤，将滤液回收乙醇后浓缩为温度45-55℃时相对密度为1.28的稠膏；
(5)将步骤(4)中的药渣与上肉桂、北细辛、麻黄、生川乌、生草乌、酒曲银杏叶、黄芪、半支莲、垂盆草、莱菔子、大青叶、金樱子、板蓝根、蒲公英、金银花、白芍和花椒合并后，加5倍的水煎煮2次，每次2h，合并煎煮液并过滤，将滤液浓缩为温度50℃时相对密度为1.28的稠膏；
(6)将步骤(4)和步骤(5)得到的稠膏混匀后，加入黑面神粉末，经混匀、制粒烘干后得到成品。
实施例4
一种用于治疗猪腹泻的植物复方药剂，按照重量份的原料包括：黑面神75份、甘草11份、茯苓25份、川芎28份、广木香28份、上肉桂28份、北细辛30份、麻黄35份、生川乌30份、元参35份、黄柏35份、生草乌30份、酒曲45份、丹皮35份、当归22份、银杏叶25份、黄芪45份、半支莲18份、垂盆草18份、莱菔子18份、大青叶11份、槟榔11份、金樱子11份、板蓝根35份、马齿苋22份、黄连4.5份、蒲公英18份、金银花28份、白芍5.5份、花椒2.5份。
所述用于治疗猪腹泻的植物复方药剂的制备方法，具体步骤如下：
(1)按照重量份称取各原料；
(2)将马齿苋、黄连、丹皮、元参和黄柏分别洗净后制成粗粉；
(3)取黑面神拣选、洗净、烘干后粉碎过110目筛得到黑面神粉末备用；
(4)将甘草、茯苓、川芎、广木香、当归和槟榔拣选、洗净、烘干，分别或混合后粉碎，再与步骤(2)得到的粗粉混合，用浓度为75％的乙醇浸泡2.8h，再用浓度为75％的乙醇加热回流5次，每次2.5h，合并回流液后过滤，将滤液回收乙醇后浓缩为温度52℃时相对密度为1.29的稠膏；
(5)将步骤(4)中的药渣与上肉桂、北细辛、麻黄、生川乌、生草乌、酒曲银杏叶、黄芪、半支莲、垂盆草、莱菔子、大青叶、金樱子、板蓝根、蒲公英、金银花、白芍和花椒合并后，加5.5倍的水煎煮3次，每次2.2h，合并煎煮液并过滤，将滤液浓缩为温度52℃时相对密度为1.29的稠膏；
(6)将步骤(4)和步骤(5)得到的稠膏混匀后，加入黑面神粉末，经混匀、制粒烘干后得到成品。
实施例5
一种用于治疗猪腹泻的植物复方药剂，按照重量份的原料包括：黑面神80份、甘草12份、茯苓30份、川芎30份、广木香30份、上肉桂30份、北细辛35份、麻黄40份、生川乌35份、元参40份、黄柏40份、生草乌35份、酒曲50份、丹皮40份、当归25份、银杏叶30份、黄芪50份、半支莲20份、垂盆草20份、莱菔子20份、大青叶12份、槟榔12份、金樱子12份、板蓝根40份、马齿苋25份、黄连5份、蒲公英20份、金银花30份、白芍6份、花椒3份。
所述用于治疗猪腹泻的植物复方药剂的制备方法，具体步骤如下：
(1)按照重量份称取各原料；
(2)将马齿苋、黄连、丹皮、元参和黄柏分别洗净后制成粗粉；
(3)取黑面神拣选、洗净、烘干后粉碎过120目筛得到黑面神粉末备用；
(4)将甘草、茯苓、川芎、广木香、当归和槟榔拣选、洗净、烘干，分别或混合后粉碎，再与步骤(2)得到的粗粉混合，用浓度为80％的乙醇浸泡3h，再用浓度为80％的乙醇加热回流6次，每次3h，合并回流液后过滤，将滤液回收乙醇后浓缩为温度55℃时相对密度为1.3的稠膏；
(5)将步骤(4)中的药渣与上肉桂、北细辛、麻黄、生川乌、生草乌、酒曲银杏叶、黄芪、半支莲、垂盆草、莱菔子、大青叶、金樱子、板蓝根、蒲公英、金银花、白芍和花椒合并后，加6倍的水煎煮3次，每次2.5h，合并煎煮液并过滤，将滤液浓缩为温度55℃时相对密度为1.3的稠膏；
(6)将步骤(4)和步骤(5)得到的稠膏混匀后，加入黑面神粉末，经混匀、制粒烘干后得到成品。
临床疗效观察：
本中药组合物分别在56个猪场进行了临床应用试验，这些猪场都是仔猪在断奶后发生腹泻，各种抗生素类药物治疗效果差，死亡率较高。
治疗与观察方法：各发病猪场停用其他种类治疗腹泻病的药物，在饲料中按1％的比例添加本发明植物复方药剂，连续使用10-15天，同时配合改善饲养管理条件、加强消毒，并且在饮水中加入0.5％葡萄糖、0.1％的电解多维、0.1％的口服补液盐，以防止因腹泻脱水而死亡。期间观察其疗效。
疗效判断：痊愈：腹泻症状完全消失，仔猪恢复正常食欲和精神状态。显效：使用本发明中药组合物15天后，腹泻症状明显减少，70％以上发病猪恢复正常。好转：使用本发明中药组合物15天后，腹泻症状有所减轻，但仍有30-70％的病猪，无效，连续使用本药15天，症状不见改善。
疗效结果：通过在56个猪场使用，其中完全治愈的有12个猪场，效果显著的30个猪场，好转的有10个猪场，无效4个猪场，由此可知，本发明的植物复方药剂防治断奶仔猪腹泻的有效率达到92.8％，疗效显著。
本发明采用纯中草药配制而成，能有效杀灭引发猪流行性腹泻和猪传染性胃肠炎的病毒，无须使用其它一切抗菌药物，尤其适用于抗生素治疗效果不明显的病例，能充分体现中医药的整体观念和优势，使药效和功能更为全面达到标本兼治，具有配方绿色环保、工艺简单合理、制作成本低、预防和治疗效果好、药副作用小的优点。
上面对本专利的较佳实施方式作了详细说明，但是本专利并不限于上述实施方式，在本领域的普通技术人员所具备的知识范围内，还可以在不脱离本专利宗旨的前提下作出各种变化。

Claims (4)

1.一种用于治疗猪腹泻的植物复方药剂，其特征在于，按照重量份的原料包括：黑面神60-80份、甘草8-12份、茯苓10-30份、川芎20-30份、广木香20-30份、上肉桂20-30份、北细辛15-35份、麻黄20-40份、生川乌15-35份、元参20-40份、黄柏20-40份、生草乌15-35份、酒曲30-50份、丹皮20-40份、当归15-25份、银杏叶10-30份、黄芪30-50份、半支莲10-20份、垂盆草10-20份、莱菔子10-20份、大青叶8-12份、槟榔8-12份、金樱子8-12份、板蓝根20-40份、马齿苋15-25份、黄连3-5份、蒲公英10-20份、金银花20-30份、白芍4-6份、花椒1-3份。
2.根据权利要求1所述的用于治疗猪腹泻的植物复方药剂，其特征在于，按照重量份的原料包括：黑面神65-75份、甘草9-11份、茯苓15-25份、川芎22-28份、广木香22-28份、上肉桂22-28份、北细辛20-30份、麻黄25-35份、生川乌20-30份、元参25-35份、黄柏25-35份、生草乌20-30份、酒曲35-45份、丹皮25-35份、当归18-22份、银杏叶15-25份、黄芪35-45份、半支莲12-18份、垂盆草12-18份、莱菔子12-18份、大青叶9-11份、槟榔9-11份、金樱子9-11份、板蓝根25-35份、马齿苋18-22份、黄连3.5-4.5份、蒲公英12-18份、金银花22-28份、白芍4.5-5.5份、花椒1.5-2.5份。
3.根据权利要求1所述的用于治疗猪腹泻的植物复方药剂，其特征在于，按照重量份的原料包括：黑面神70份、甘草10份、茯苓20份、川芎25份、广木香25份、上肉桂25份、北细辛25份、麻黄30份、生川乌25份、元参30份、黄柏30份、生草乌25份、酒曲40份、丹皮30份、当归20份、银杏叶20份、黄芪40份、半支莲15份、垂盆草15份、莱菔子15份、大青叶10份、槟榔10份、金樱子10份、板蓝根30份、马齿苋20份、黄连4份、蒲公英15份、金银花25份、白芍5份、花椒2份。
4.一种如权利要求1-3任一所述的用于治疗猪腹泻的植物复方药剂的制备方法，其特征在于，具体步骤如下：
(1)按照重量份称取各原料；
(2)将马齿苋、黄连、丹皮、元参和黄柏分别洗净后制成粗粉；
(3)取黑面神拣选、洗净、烘干后粉碎过80-120目筛得到黑面神粉末备用；
(4)将甘草、茯苓、川芎、广木香、当归和槟榔拣选、洗净、烘干，分别或混合后粉碎，再与步骤(2)得到的粗粉混合，用浓度为60-80％的乙醇浸泡2-3h，再用浓度为60-80％的乙醇加热回流2-6次，每次1-3h，合并回流液后过滤，将滤液回收乙醇后浓缩为温度45-55℃时相对密度为1.25-1.3的稠膏；
(5)将步骤(4)中的药渣与上肉桂、北细辛、麻黄、生川乌、生草乌、酒曲银杏叶、黄芪、半支莲、垂盆草、莱菔子、大青叶、金樱子、板蓝根、蒲公英、金银花、白芍和花椒合并后，加4-6倍的水煎煮2-3次，每次1.5-2.5h，合并煎煮液并过滤，将滤液浓缩为温度45-55℃时相对密度为1.25-1.3的稠膏；
(6)将步骤(4)和步骤(5)得到的稠膏混匀后，加入黑面神粉末，经混匀、制粒烘干后得到成品。
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CN106139121A (zh) * 2016-09-21 2016-11-23 广西大学 一种含肉桂、金樱子和粘杆菌素的畜禽用复方药物
CN106474395A (zh) * 2016-11-30 2017-03-08 广西南宁桂知科技有限公司 一种含黑面神的药物组合物

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CN102302599A (zh) * 2011-09-06 2012-01-04 河南省农业科学院 用于防治猪腹泻的中药组合物

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106139121A (zh) * 2016-09-21 2016-11-23 广西大学 一种含肉桂、金樱子和粘杆菌素的畜禽用复方药物
CN106474395A (zh) * 2016-11-30 2017-03-08 广西南宁桂知科技有限公司 一种含黑面神的药物组合物

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