CN105816649A - 一种用于除湿止痒的中药组合物及其制备方法和用途 - Google Patents
一种用于除湿止痒的中药组合物及其制备方法和用途 Download PDFInfo
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Abstract
本发明公开了一种用于除湿止痒的中药组合物。按重量份计，由以下原料制成：人参10～20份、灵芝草10～20份、麦冬20～30份、黄芩20～30份、银杏叶15～30份、蜂胶1～5份、甘草10～15份和白茶5～10份。本发明的用于除湿止痒的中药组合物能预防和护理皮肤病，尤其是在护理和预防湿疹、皮炎、廯症方面具有高效、安全、可控性强，无毒副作用的优点，为临床治疗预防皮肤病提供了新的选择。
Description
技术领域：
本发明属于化妆品领域，具体涉及一种用于除湿止痒的植物组合物及其制备方法和用途。
背景技术：
湿疹是由多种内外因素引起的，一种常见的变态反应性、非传染性和过敏性皮肤表皮及真皮浅层的炎症性皮肤病。湿疹的发作主要为四肢，其临床表现具有对称性、渗出性、瘙痒性、多形性和复发性等特点，发病时皮肤瘙痒难耐。湿疹的主要症状为皮肤出现红斑、丘疹、水疱等，可有剧烈的瘙痒，搔破后局部渗液、糜烂，也可感染化脓，常可反复发作。
目前临床应用的抗湿疹药物主要包括：(1)抗组胺药物，如第1，2和3代抗组胺药物。(2)过敏反应介质阻断剂，如色甘酸钠和甲派噻庚酮。(3)钙剂，如葡萄糖酸钙和氯化钙。(4)免疫抑制剂，如皮质类固醇。这些药物祛湿止痒，疗效明确，起效迅速，属于对症治疗，但存在停药后复发率高，同时不良反应多，如嗜睡、口干、头晕等。相比湿疹疾病的高发率，仅仅依赖于药物治疗并不能改善患者的状况。因此，有必要应用现代萃取技术，结合现代给药方式，研制新型的止痒除湿辅助产品，通过皮肤表皮外用直达病灶，以减轻该类人群的苦痛和提高生活质量。
中医典籍记载及中医药临床实践证明，具有止痒除湿作用的植物提取物，都有一定的缓解或治疗湿疹症状的作用。我国植物资源丰富，草药历史悠久，用于止痒除湿的植物药有黄柏、苍术、苦参、车前草、蛇床子、黄芩、黄连，具有清热利湿、凉血功能，以及薄荷、菊花、艾叶、丁香、藿香、薰衣草和金银花等，其挥发油具有清凉止痒的作用。
将植物的活性物质应用于日化系列产品，既有滋养肌肤的作用，又可以缓解皮肤不适症状，是当前科技发展和日化产品走向纯天然的共同结晶。天然植物化妆品，是运用现代科学技术，对植物的有效成分进行萃取，借助化妆品的基质配方，研制而成的一种新型功能性化妆品。天然植物提取物添加到护肤品中，可以达到护理干燥、湿疹、痤疮等问题性皮肤以及在净化自由基、防衰老、修护肌肤等方面发挥功效。而且植物提取物的天然香味，可以完全替代化学香精，其香味更为舒缓自然。
发明内容：
本发明的目的是提高一种用于除湿止痒的中药组合物及其制备方法和用途。
本发明的用于除湿止痒的中药组合物，其特征在于，按重量份计，由以下原料制成：人参10～20份、灵芝草10～20份、麦冬20～30份、黄芩20～30份、银杏叶15～30份、蜂胶1～5份、甘草10～15份和白茶5～10份。
优选，按重量份计，由以下原料制成：人参10份、灵芝草10份、麦冬20份、黄芩20份、银杏叶30份、蜂胶2份、甘草10份和白茶5份。
本发明用于除湿止痒的中药组合物是以人参、灵芝草、麦冬、黄芩、银杏叶、蜂胶、甘草和白茶提取物为活性成分，加入日化上可以接受的辅料或日化上可以接受的基质制备而成的制剂或日化产品。
其中所述的制剂和日化产品是外用品。
进一步地，所述的制剂是膏剂、涂膜剂、擦剂、气雾剂、喷雾剂、泡腾片、外用品或霜剂。
本发明还提供了该用于除湿止痒的中药组合物的制备方法，它包括如下步骤：
a.按重量份称取原料：人参10-20份、灵芝草10-20份、麦冬20-30份、黄芩20-30份、银杏叶15-30份、蜂胶1-5份、甘草10-15份和白茶5-10份；
b.取人参、灵芝草、麦冬用水煎煮，收集煎煮液，过滤，冷冻干燥，得冻干粉；
c.取黄芩、银杏叶和甘草用体积分数95％乙醇水溶液渗漏提取，减压浓缩，得浸膏，浸膏冷冻干燥，得冻干粉；
d、将白茶用水煎煮，收集煎煮液，过滤，冷冻干燥，得冻干粉；
e.将步骤b、c、d的冻干粉、浸膏与蜂胶混合，制成用于除湿止痒的中药组合物。
该用于除湿止痒的中药组合物可以加入日化可以接受的辅料或辅助性液体溶解混合后制备成制剂或产品。
本发明还提供了该用于除湿止痒的中药组合物在制备湿疹性皮肤防护剂中的应用。
本发明还提供了该用于除湿止痒的中药组合物在制备护理过敏性皮肤瘙痒症的日化产品中的应用。
一种湿疹性皮肤防护剂或护理过敏性皮肤瘙痒症的日化产品，其特征在于，含有有效量的用于除湿止痒的中药组合物作为有效成分。
本发明前期对具有除湿、抗过敏、消炎、止痒的一百多种药用植物进行了系统筛选和动物实验，发现一组植物提取物组合物，具有很强的外用保护敏感肌肤和修护湿疹问题肌肤的作用。并研究了其提取方法和在日化产品中的应用。
本发明所采用的植物提取物其化学成分明确，除湿止痒作用机制清晰，并且全部录入化妆品添加剂目录，使用安全、有效。
具体的植物组合物包括：人参、灵芝草、麦冬、黄芩、银杏叶、蜂胶、甘草和白茶。
人参：人参为五加科多年生草本植物，被誉为“百草之王”，主要以根和茎入药，可以润燥、生津止渴，补益身体。人参中含有丰富的皂苷、多糖、挥发油、生物碱、氨基酸、多肽等化学成分，具有抗氧化、增强免疫、抗肿瘤等生理功能。人参皂苷具有很好的抗皮肤过敏作用，过敏介质释放和活性检测试验以及小鼠被动皮肤过敏反应实验表明，人参皂苷可以强烈抑制RBL-2H3释放β-氨基己糖酶，抑制透明质酸酶活性，从而抑制皮肤过敏反应。
人参提取物大量的应用于日化系列产品，可以抗肌体过氧化，增强自由基防御酶的活性，减少皮肤自由基的生成，对已产生的自由基进行有效清除，进而延缓衰老。人参提取物能够与微血管中的凝血因子结合，降低血管中纤维蛋白水平，畅通血管，从而改善皮肤新陈代谢，达到血管美容的效果。此外，人参提取物能够刺激细胞生长因子，如纤维细胞生长因子(FGF)和表皮生长因子(EGF)，能够修复皮下断裂纤维，促进表皮细胞代谢及再生，通过激活细胞的生长因子而修复受损的皮肤组织。因此，本配方选择人参提取物来抑制皮肤过敏反应，修复皮肤，使皮肤恢复健康，更加完美。
黄芩：为唇形科植物ScutellariabaicalensisGeorgi的干燥根，主要具有清热燥湿，泻火解毒等作用，已有悠久的用药历史，是我国中医临床常用中药品种之一，并且进入化妆品添加植物名录。对黄芩祛湿抗炎作用的研究报道较多，主要为黄芩黄酮类成分，包括黄芩苷、黄芩素、汉黄芩苷和汉黄芩素。对黄芩抗过敏作用研究表明，黄芩苷和黄芩素对豚鼠过敏性哮喘、支气管等所引起的过敏性收缩均具明显的抑制作用；过敏豚鼠的离体回肠、对同种或异种抗原所引起的被动过敏反应也有抑制效果，其作用机制主要是抑制过敏介质(组胺、慢反应物质SRS-A)的释放。黄芩素可以抑制小鼠迟发性变态反应性耳肿、豚鼠皮肤血管炎症反应以及小鼠被动皮肤过敏反应，可以明显抑制小鼠瘙痒反应、豚鼠足痒反应，抑制组胺引起的离体回肠收缩，抑制小鼠耳肿反应。黄芩苷元能对豚鼠被动型皮肤过敏反应、组织胺皮肤反应表现抑制，在抗变态反应方面，苷元较苷作用强。因此，本组方利用黄芩的清热利湿作用，将其黄酮类成为作为活性成分，应用于除湿止痒配方，发挥主要作用。
银杏叶：素有“植物活化石”之称，药用历史久远，民间早有用银杏叶煎汤治疗未溃冻疮的秘方。银杏叶富含有黄酮类、萜内酯类、有机酸类、有机醇类、矿物质、维生素、氨基酸等多种活性物质和生物原色。其中黄酮是强有力的氧自由基清除剂，能保护皮肤细胞不受氧自由基过度氧化的影响。银杏叶提取物在日化产品中大量使用，如银杏叶洁面霜不但能够彻底清除毛孔深处污物，令肌肤焕发水润的自然光泽，还可以阻碍色素在真皮层的形成与沉着，达到美白肌肤防治色素斑块的作用。此外，银杏提取物中的内酯类物质也能加速新陈代谢，改善血流循环，增强细胞活力，还具有广谱杀菌作用，使用银杏产品可治疗面部癣疱和瘙痒、手部破裂等多种皮肤疾患。药理学研究表明，银杏叶提取物中所含有的银杏甲素，能够抑制小鼠足垫迟发型超敏反应，拮抗过敏介质引起的回肠收缩，对抗过敏介质而发挥作用。银杏叶提取物可以抑制RBL-2H3细胞释放组胺、白细胞三烯(CA)、IL-4及TNF-α,抑制Akt和p38的磷酸化，抑制皮肤过敏反应。因此，本组分选择银杏叶起到滋养皮肤的作用。
灵芝草：灵芝草为多孔菌植物紫芝Ganodermajaponicum或赤芝Ganodermalucidum的全株，作为我国古老的药膳食物，距今约有四千年的食用和药用历史。灵芝草含有麦角甾醇、三萜、有机酸、氨基葡萄糖、多糖类、树脂、甘露醇等。明李时珍《本草纲目》记载，其性平、味甘，归心、肺、肝、肾经，有益肺气、补肝气、利关节、祛痰等功效，用于补气安神，止渴平喘、眩晕不眠、心悸气短、虚劳咳嗽等症。灵芝的子实体除了有补益身体的功效外，还具有很好的抗过敏效果，在有关灵芝的专利中，发现赤灵芝常与其它中药配伍治疗过敏性疾病，如将赤芝、丹参、浙贝、鹅不食草、地龙、海藻、蜂蜜及冰片联合使用治疗鼻炎。灵芝、半夏、苏叶、厚朴、茯苓、冰糖配伍治疗过敏性哮喘。由中药苦参、灵芝和甘草组成的哮喘药ASHMI，已经通过美国FDA的认可，进入临床研究。大量的研究表明紫灵芝和赤芝的提取物可以减少过敏介质IgE和IgG2a抗体的含量，抑制肥大细胞分泌组织胺，促进树突细胞产生IL-12p70，IL-12p40，IL-6，IL-23和IL-10，同时还能逆转Th2介导的反应，其中所含有的三萜和多糖可以有效的降低IL-5的释放，这些药理数据说明灵芝草内服和外用都可以用于治疗过敏性疾病。本组方选用灵芝草起到抗过敏的作用。
麦冬：又名沿阶草，书带草，为百合科沿阶草属植物麦门冬Ophiopogonjaponicas，常以干燥块根入药。《本草汇言》记载，麦门冬，味甘、苦，性微寒，归心、肺、胃经，可谓清心润肺之药。麦冬中主要的化学成分有多糖、甾体皂苷、高异黄酮类，而麦冬多糖是麦冬中的主要功效性成分之一，其含量高达20％。麦冬多糖对呼吸系统有较明显作用，具有抗过敏和平喘作用。在化妆品应用方面，麦冬多糖有良好的持水性，是一种天然的保湿成分，对皮肤的粘附性强，伸展性高，可用于皮肤、唇膏、口红和粉饼膏霜中，它还具有抗氧化、延缓衰老等生物活性。因此，本组方选择麦冬起滋润保持的作用。
蜂胶：为蜜蜂科昆虫中华蜜蜂等所分泌的黄褐色或黑褐色的粘性物质。蜂胶是一种极为稀少的天然资源，素有“紫色黄金”之称，通常含有55％的树脂和树香、30％左右的蜂蜡、10％的芳香挥发油和5％的花粉及夹杂物。蜂胶的成分中，最具代表性的活性物质是黄酮类化合物槲皮素和萜类及有机酸中的咖啡酸苯乙酯。槲皮素具有抗氧化、消炎、扩张冠状血管、降低血脂、抗血小板凝聚等作用。除黄酮类化合物外，蜂胶还有芳香挥发油，烯萜类化合物，有机酸类，黄烷醇类，醇、酚、醛、酮、酯、醚类化合物，酶类及无机盐等，蜂胶犹如一个天然的“药库”，具有抗无名痒、过敏、解毒等生物功效。本组方选用蜂胶作为配方成分，主要是蜂胶的解毒作用和树脂类成分，以及天然芳香挥发油，为产品提供天然香气。
白茶：中国是茶的故乡，根据茶叶的生境、香味和内含物的不同，采用不同的烘焙和发酵方式，进而最大可能的保留茶叶的色香味和生物功效。白茶是茶叶的极品，采用最为简单的揉搓和自然风干方式制作而成，因此完完整整的保留了茶叶的天然特性。茶叶中所含有的内生菌也能够存活下来，与茶叶共同后续发酵，最终大大的提高了茶叶的品质。因此，白茶具有性清凉，消热降火，消暑解毒的特殊功效。清代周亮工的《闽小记》载：“白毫银针，产太姥山鸿雪洞，其性寒凉，功同犀角，是治麻疹之圣药。白茶提取物对葡萄球菌引起感染、链球菌引起感染、肺炎等细菌生长具有预防作用。此外，白茶中的茶多酚含量较高，茶多酚等活性物质具有解毒和抗辐射的作用，它是一种新型天然抗氧化剂，在常温和低浓度下具有很强的抗氧化作用，对胶原酶和弹性蛋白酶有抑制作用，可阻止弹性蛋白质的含量下降或变性，维持皮肤弹性，达到抗皱效果。茶多酚能明显抑制皮肤过敏反应、组胺所引起的回肠平滑肌收缩，抑制致敏豚鼠肺组织中SRS-A的释放。因此，本组方将茶多酚的抗氧化和清火解毒功效发挥出来，用于除湿止痒组分，白茶的清火降热和抗菌的功效也被用于本配方中。
甘草：为豆科植物甘草glycyrrhizauralensis的根及根状茎，甘草的主要化学成分是三萜类和黄酮类化合物。甘草中的黄酮对人体的皮肤有较好的美白和防护作用，且安全、温和、能有效清除氧自由基。因而，甘草在化妆品中的应用越来越受到重视。甘草黄酮可以通过抑制酪氨酸酶和多巴色素互变酶(TRP-2)的活性，阻碍5,6-二羟基吲哚(DHI)的聚合，以此来阻止黑色素的形成，从而达到美白皮肤的效果。因此，本配方选择甘草起美白肌肤和抗氧化的功效。
本发明的用于除湿止痒的中药组合物能预防和护理皮肤病，尤其是在护理和预防湿疹、皮炎、廯症方面具有高效、安全、可控性强，无毒副作用的优点，为临床治疗预防皮肤病提供了新的选择。
具体实施方式：
以下实施例是对本发明的进一步说明，而不是对本发明的限制。
实施例1：
a.取人参500g、灵芝草500g、麦冬1000g，加蒸馏水5.0L，沸水浴煮2h后，浸出水液，再加入5L水继续沸水煮2h，合并两次水浸出液，减压浓缩，蒸除2/3水分，浓缩后的浸提液于-80℃冷冻干燥，得冻干粉。
b.取黄芩1000g、银杏叶1500g和甘草500g，加10L体积分数95％乙醇水溶液于常温下浸提3次，每次24h，合并三次的浸提液，过滤后于60℃减压浓缩，蒸除乙醇，浓缩浸膏于-80℃冷冻干燥，得冻干粉。
c.取白茶250g用80℃温水浸泡2h，收集浸出液，过滤后于60℃减压蒸除2/3水分，余液于-80℃冷冻干燥，得冻干粉。
d.将上述a、b和c的冻干粉与100g蜂胶合并，得本发明的用于除湿止痒的中药组合物。
实施例2
本发明具有止痒除湿防护作用的膏霜的基本配方如下：
本发明制备的具有止痒除湿防护作用的膏霜，其外观乳黄色膏体，Ph5.6-6.5之间，48℃耐热30天，-5-15℃耐寒30天，恢复室温后均正常。
实施例3
以下通过药效学实验证明本发明的药物的作用效果。
从动物实验的方面验证本发明的止痒和抗过敏作用。
1.组胺致豚鼠局部瘙痒反应实验
取白色豚鼠40只，♀各半，随机分为4组，即空白对照组(蒸馏水)、膏霜基质组、膏霜组(含2％提取物，即实施例2的具有止痒除湿防护作用的膏霜)、阳性对照组(苯海明拉乳膏)，每组10只。实验前一天剪去各豚鼠右后足背毛，并用电动剃须刀剃净，面积约1cm×0.5cm。24h后，经皮给予相应受试药物，空白组不予给药，1次/d，连续5d。末次给药60min后，用粗砂纸擦伤剃毛处，以使之发红、不出血为度，面积为1cm2，10min后开始在创面处滴0.01％磷酸组织胺0.05ml/只，此后每隔3min依0.02％，0.03％…递增浓度，每次均为0.05ml/只，直至豚鼠回头舔右后足时所给予的磷酸组织胺总量(μg)为致痒阀。并记录各组致痒阀。
表1具有止痒除湿防护作用的膏霜对豚鼠局部瘙痒反应的影响
结果如表1所示，表1表明，与空白对照组和阳性对照组相比，本发明的具有止痒除湿防护作用的膏霜能够明显提高豚鼠的止痒阀，减少小鼠的舔体次数。
2.抗过敏作用
2.1对大鼠同种被动皮肤过敏反应(PCA)的影响
健康大鼠2只，雌雄各l只，体重190-200g，用卵白蛋白生理盐水溶液按10mg/kg肌内注射于后腿两侧，同时腹腔注射百日咳疫苗2×1010/只。14天后处死动物采血，分离血清，置冰箱备用。
另取健康大鼠40只，体重180～200g，♀各半，随机分成4组，即空白对照组(蒸馏水)、膏霜基质组、膏霜组(含2％提取物，即实施例2的具有止痒除湿防护作用的膏霜)、阳性对照组(苯海明拉乳膏)。各组动物用乙醚浅麻醉，在大鼠背中线两侧，距脊柱1.5cm处把毛剪光，每点间隔1.5～2cm。取上述血清，经生理盐水1∶10、1∶20倍稀释，皮内注射于剪毛的各点。48h后进行抗原攻击，静脉注射0.5％依文思蓝抗原注射液1.0mL(含1mg卵白蛋白)。经20min后，处死动物，剪下背部皮肤，检查注射各点蓝色反应斑直径。
表2大鼠同种被动皮肤过敏反应(PCA)的影响
结果如表2所示，表2表明，膏霜组对大鼠同种被动皮肤过敏反应(PCA)均有明显的抑制作用，与水对照组比较，P＜0.01，抑制率达到22.8-28.9％。
2.2对2,4-二硝基氟苯(DNFB)致小鼠迟发型超敏反应(DTH)的影响
取ICR小鼠40只，随机均分为4组。即空白对照组(蒸馏水)、膏霜基质组、膏霜组(含2％提取物，即实施例2的具有止痒除湿防护作用的膏霜)、阳性对照组(苯海明拉乳膏)，实验时每鼠腹部去毛，范围3cm×3cm。将3％DNFB丙酮液20μL均匀涂抹致敏。第2天强化1次。于致敏前一天涂相应药物，1次/天，共8天。致敏6天后，将l％DNFB丙酮液10μL均匀涂抹于每鼠右耳(两面)进行攻击。于第8天末次给药后lh处死小鼠，用打孔器打下直径9mm的左右两耳片，称重。以左右耳片重量之差为肿胀度，比较各组小鼠耳廓肿胀程度的差异。
表3对2,4-二硝基氟苯(DNFB)致小鼠迟发型超敏反应(THD)的影响
结果如表3所示，表3表明，膏霜组对2,4－二硝基氟苯(DNFB)致小鼠小鼠迟发型超敏反应(THD)明显的抑制作用，与水对照组比较P<0.001。
3.临床使用效果统计分析
湿疹程度分析标准：
轻度：红斑丘疹颜色浅或淡暗，没有水泡或轻微水泡。
中度：皮损为红斑丘疹色泽红，皮肤有轻度肿胀和水泡。
重度：皮损为明显潮红肿胀：大量密集水泡、糜烂、渗水。
使用效果评定标准
修复：无痒感，皮肤恢复正常。
显效：痒感减弱，皮损程度明显减轻，修复率在60％以上。
有效：痒感减弱，皮损程度未减轻，皮损面积消退不足30％。
使用记录：
药膏(实施例2的具有止痒除湿防护作用的膏霜)随机选择100人进行试验，包括五个年龄段，60岁以上20人，40-60岁20人,18-35岁20人，5-18岁20人，1-5岁20人
对照组：苯海明拉乳膏
两组患者总疗效比较
| 组别 | 例数 | 痊愈 | 显效 | 有效 | 无效 | 总有效率 |
| 治疗组 | 200 | 68 | 56 | 38 | 38 | 81％ |
| 对照组 | 50 | 2 | 8 | 13 | 27 | 46％ |
两组痊愈病人疗程比较
| 组别 | 例数 | 治愈例数 | 治愈者平均用药天数(Mean±SD) |
| 治疗组 | 200 | 68 | 7±2 |
| 对照组 | 50 | 2 | 11±1 |
使用结果表明，本发明的实施例2的具有止痒除湿防护作用的膏霜对湿疹性皮肤问题在各个年龄阶段都表现出很好的作用，治愈率明显高于阳性对照组，总有效率也在81％，充分显示的纯天然配方产品的优势和功效。
实施例3：
a.取人参1000g、灵芝草1000g、麦冬1500g，加蒸馏水10.0L，沸水浴煮2h后，浸出水液，再加入10L水继续沸水煮2h，合并两次水浸出液，减压浓缩，蒸除2/3水分，浓缩后的浸提液于-80℃冷冻干燥，得冻干粉。
b.取黄芩1500g、银杏叶750g和甘草750g，加10L体积分数95％乙醇水溶液于常温下浸提3次，每次24h，合并三次的浸提液，过滤后于60℃减压浓缩，蒸除乙醇，浓缩浸膏于-80℃冷冻干燥，得冻干粉。
c.取白茶500g用80℃温水浸泡2h，收集浸出液，过滤后于60℃减压蒸除2/3水分，余液于-80℃冷冻干燥，得冻干粉。
d.将上述a、b和c的冻干粉与50g蜂胶合并，得本发明的用于除湿止痒的中药组合物。
实施例4：
a.取人参1000g、灵芝草1000g、麦冬1500g，加蒸馏水10.0L，沸水浴煮2h后，浸出水液，再加入10L水继续沸水煮2h，合并两次水浸出液，减压浓缩，蒸除2/3水分，浓缩后的浸提液于-80℃冷冻干燥，得冻干粉。
b.取黄芩1500g、银杏叶1250g和甘草750g，加10L体积分数95％乙醇水溶液于常温下浸提3次，每次24h，合并三次的浸提液，过滤后于60℃减压浓缩，蒸除乙醇，浓缩浸膏于-80℃冷冻干燥，得冻干粉。
c.取白茶500g用80℃温水浸泡2h，收集浸出液，过滤后于60℃减压蒸除2/3水分，余液于-80℃冷冻干燥，得冻干粉。
d.将上述a、b和c的冻干粉与250g蜂胶合并，得本发明的用于除湿止痒的中药组合物。
Claims (6)
1.一种用于除湿止痒的中药组合物，其特征在于，按重量份计，由以下原料制成：人参10～20份、灵芝草10～20份、麦冬20～30份、黄芩20～30份、银杏叶15～30份、蜂胶1～5份、甘草10～15份和白茶5～10份。
2.根据权利要求1所述的用于除湿止痒的中药组合物，其特征在于，按重量份计，由以下原料制成：人参10份、灵芝草10份、麦冬20份、黄芩20份、银杏叶30份、蜂胶2份、甘草10份和白茶5份。
3.一种用于除湿止痒的中药组合物的制备方法，其特征在于，包括以下步骤：
a.按重量份称取原料：人参10-20份、灵芝草10-20份、麦冬20-30份、黄芩20-30份、银杏叶15-30份、蜂胶1-5份、甘草10-15份和白茶5-10份；
b.取人参、灵芝草、麦冬用水煎煮，收集煎煮液，过滤，冷冻干燥，得冻干粉；
c.取黄芩、银杏叶和甘草用体积分数95％乙醇水溶液渗漏提取，减压浓缩，得浸膏，浸膏冷冻干燥，得冻干粉；
d、将白茶用水煎煮，收集煎煮液，过滤，冷冻干燥，得冻干粉；
e.将步骤b、c、d的冻干粉与蜂胶混合，制成用于除湿止痒的中药组合物。
4.权利要求1所述的用于除湿止痒的中药组合物在制备湿疹性皮肤防护剂中的应用。
5.权利要求1所述的用于除湿止痒的中药组合物在制备护理过敏性皮肤瘙痒症的日化产品中的应用。
6.一种湿疹性皮肤防护剂或护理过敏性皮肤瘙痒症的日化产品，其特征在于，含有有效量的用于除湿止痒的中药组合物作为有效成分。
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| CN114767602A (zh) * | 2022-03-03 | 2022-07-22 | 广州天玺生物科技有限公司 | 天冬组合在制备舒缓作用化妆品中的用途 |
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