CN105816576A - Propolis soft capsules - Google Patents
Propolis soft capsules Download PDFInfo
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- CN105816576A CN105816576A CN201610165075.4A CN201610165075A CN105816576A CN 105816576 A CN105816576 A CN 105816576A CN 201610165075 A CN201610165075 A CN 201610165075A CN 105816576 A CN105816576 A CN 105816576A
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- 239000007901 soft capsule Substances 0.000 title claims abstract description 23
- 241000241413 Propolis Species 0.000 title claims abstract description 15
- 229940069949 propolis Drugs 0.000 title claims abstract description 15
- 235000000060 Malva neglecta Nutrition 0.000 claims abstract description 12
- 240000000982 Malva neglecta Species 0.000 claims abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 12
- 238000002360 preparation method Methods 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- 239000003292 glue Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000012567 medical material Substances 0.000 claims description 8
- 230000003078 antioxidant effect Effects 0.000 claims description 7
- 239000002671 adjuvant Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 4
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 4
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 4
- 238000004364 calculation method Methods 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 229940010454 licorice Drugs 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 239000000047 product Substances 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- 238000001694 spray drying Methods 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 240000004670 Glycyrrhiza echinata Species 0.000 claims 1
- 238000005516 engineering process Methods 0.000 abstract description 4
- 244000103926 Chamaenerion angustifolium Species 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 235000008302 Chamaenerion angustifolium Nutrition 0.000 abstract 1
- 241000284147 Clerodendrum fortunatum Species 0.000 abstract 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 241000208672 Lobelia Species 0.000 abstract 1
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- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Insects & Arthropods (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention belongs to the field of traditional Chinese medicine preparations, and particularly provides propolis soft capsules.The active ingredients contained in the propolis soft capsules are prepared by extracting, by weight, 2 parts of propolis, 28 parts of all-grass of tali lobelia, 16 parts of roots of malva rotundifolia, 22 parts of roots of clerodendrum fortunatum, 18 parts of rhizomes or herb of chamaenerion angustifolium (L.) Scop.and 5 parts of liquorice roots.The raw materials are prepared into the soft capsules by adopting a conventional production technology, and the propolis soft capsules can resist oxidation.
Description
Technical field
The present invention relates to health product technology field, be specifically related to a kind of for antioxidative bee glue soft capsule.
Background technology
Aging is the various hypofunction of human body and the process of homeostasis function decline occurred with age growth, varied about old and feeble theory, wherein free radical theory thinks that the aging course of body is closely related with lipid peroxidation, lipid peroxidation is to occur at a series of radical reactions in cell membrane in unsaturated fatty acid, the generation of lipid peroxide makes Cell membrane lipids composition change, cause cell membrane endoenzyme and protein denaturation, destroy cellular structures and functions, make the internal important organ heart, liver, brains etc. are impaired, therefore stable state and the balance of interior free yl are maintained, remove harmful radical reaction, interrupt lipid peroxidation, reduce the generation of lipid peroxide, accumulation, particularly significant to slow down aging.Clinical practice is a lot of in antioxidative medicine and tonic, but these kind toxic and side effects are relatively big, and is inconvenient to take, and up to now, people are look for a kind of making simple, the oxidation-resisting health-care product of taking convenience.
Summary of the invention
In order to solve the problems referred to above, it is an object of the invention to provide a kind of bee glue soft capsule and application thereof.
In order to reach this purpose, adopt the following technical scheme that
Technical scheme: a kind of bee glue soft capsule, its contained active component is extracted by following raw materials in part by weight medicine and is prepared from: propolis 2 parts, Herba Lobeliae taliensis 28 parts, dawrf mallow 16 parts, Radix Clerodendri Fortunati 22 parts, Herba Epilobii Angustifoii 18 parts, 5 parts of Radix Glycyrrhizae.
Described bee glue soft capsule, preparation process is: take Herba Lobeliae taliensis, dawrf mallow, Radix Clerodendri Fortunati, Herba Epilobii Angustifoii, licorice medicinal materials merging, boiling twice, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10-1.20, add ethanol, stirring, make alcohol content by volume percentage calculation reach 65-85%, stand, filter, filtrate reduced in volume is 1.20-1.30 to relative density when 65 DEG C and reclaims ethanol and obtain concentrated solution, concentrated solution is spray-dried, added the propolis powder of 60 mesh, add adjuvant and make soft capsule.
Described bee glue soft capsule, decocting condition is: amount of water is the 8-12 times amount of medical material weight for the first time, decocts 1-2h, and amount of water is the 6-10 times amount of medical material weight for the second time, decocts 1-2h.
Described bee glue soft capsule, described spray drying condition is: inlet temperature is 90-110 DEG C, and leaving air temp is 60-90 DEG C, and temperature of charge is 60-90 DEG C, and atomizing pressure is 0.2-0.5 MPa, and spray velocity is 1-10ml/s.
The application in preparing antioxidant health-care product of the described bee glue soft capsule.
Propolis of the present invention is the resin that Apis gathers from plant spore or trunk, is mixed into palatine gland on it, a kind of colloidal solid thing with aromatic odor that the secretions of wax gland processes.It is that Apidae animal apis cerana etc. repairs the yellowish-brown secreted by Nidus Vespae or the stickum of pitchy, can be used as medicine.The diseases such as its property is put down, bitter in the mouth, pungent, micro-sweet, has skin moistening granulation promoting, and effect of anti-inflammatory analgetic can treat gastric ulcer, oral ulcer, burn and scald, skin splitting pain, radioprotective.
Herba Lobeliae taliensis is the root of Campanulaceae Dali Herba Lobeliae Sessilifoliae.Classification system LobeliataliensisDiels, taste；Pungent；Micro-hardship；Cool in nature；Hemostasis；Synthetism；Cut disease.Operator wound；Fracture；Malaria.
Dawrf mallow is Malvaceae Malva sylvestris dawrf mallow MalvarotundifoliaL., is used as medicine with root.Spring and autumn excavates, and cleans and dries.QI invigorating hidroschesis, diuresis lactogenesis, expelling pus and toxin by strengthening QI.For anemia, hypogalactia, spontaneous perspiration, night sweat, pulmonary tuberculosis cough, nephritis.
Radix Clerodendri Fortunati is root or the root bark of Verbenaceae Fructus Seu Herba Pubescentis, and Classification system ClerodendronfortunatumL has the effects such as heat clearing away, removing toxic substances, removing heat from blood, pain relieving, cures mainly cold, fever, bloody dysentery, skin ulcer scabies, scrofula, the symptom such as swell and ache.
Herba Epilobii Angustifoii is Oenotheraceae willow herb platymiscium willow herb Chamaenerionangustifolium (L.) Scop., with root stock or all herbal medicine.Autumn adopts, and cleans and dries or using fresh herb.Restore menstrual flow and invigorate blood circulation, reducing swelling and alleviating pain.For menoxenia；Fracture, articular sprain are controlled in external.The present invention is with all herbal medicine.Remaining Chinese medicine is pharmacopeia kind.
Beneficial effect: Herba Lobeliae taliensis of the present invention, dawrf mallow QI invigorating hidroschesis are monarch drug, and Radix Clerodendri Fortunati, Herba Epilobii Angustifoii restore menstrual flow and invigorate blood circulation, and reducing swelling and alleviating pain is ministerial drug, and propolis, Radix Glycyrrhizae are adjuvant, full side mutually compatibility, heat-clearing and toxic substances removing, antioxidant effect is obvious.
Detailed description of the invention
Form by the following examples, the foregoing of the present invention is described in further detail again, but this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to Examples below, and all technology realized based on foregoing of the present invention belong to the scope of the present invention.
Embodiment 1: take propolis 2 parts, Herba Lobeliae taliensis 28 parts, dawrf mallow 16 parts, Radix Clerodendri Fortunati 22 parts, Herba Epilobii Angustifoii 18 parts, 5 parts of Radix Glycyrrhizae is standby, take Herba Lobeliae taliensis, dawrf mallow, Radix Clerodendri Fortunati, Herba Epilobii Angustifoii, licorice medicinal materials merges, boiling twice, amount of water is 8 times amount of medical material weight for the first time, decoct 2h, amount of water is 6 times amount of medical material weight for the second time, decoct 2h, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, add ethanol, stirring, alcohol content by volume percentage calculation is made to reach 85%, stand, filter, filtrate reduced in volume is 1.20 to relative density when 65 DEG C and reclaims ethanol and obtain concentrated solution, concentrated solution is spray-dried, added the propolis powder of 60 mesh, add adjuvant and make soft capsule.Described spray drying condition is: inlet temperature is 90 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 60 DEG C, and atomizing pressure is 0.5 MPa, and spray velocity is 1ml/s.
Embodiment 2: take propolis 2 parts, Herba Lobeliae taliensis 28 parts, dawrf mallow 16 parts, Radix Clerodendri Fortunati 22 parts, Herba Epilobii Angustifoii 18 parts, 5 parts of Radix Glycyrrhizae standby, take Herba Lobeliae taliensis, dawrf mallow, Radix Clerodendri Fortunati, Herba Epilobii Angustifoii, licorice medicinal materials merging, boiling twice, amount of water is 12 times amount of medical material weight for the first time, decoct 1h, amount of water is 10 times amount of medical material weight for the second time, decocts 1h.Collecting decoction, when being concentrated into 65 DEG C, relative density is 1.20, add ethanol, stirring, alcohol content by volume percentage calculation is made to reach 65%, standing, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.30 and reclaims ethanol and obtain concentrated solution, concentrated solution is spray-dried, adding the propolis powder of 60 mesh, and added adjuvant and make soft capsule, described spray drying condition is: inlet temperature is 110 DEG C, leaving air temp is 60 DEG C, temperature of charge is 90 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 10ml/s.
Embodiment 3. antioxidative pharmacodynamic study
Laboratory animal: Kunming mouse, male, body weight 18-22g, Shanghai Slac Experimental Animal Co., Ltd. provides, production licence: SCXK (Shanghai) 2007-0005.
Experimental agents: the bee glue soft capsule prepared by above-described embodiment 1 preparation method.
Dosage: mouse stomach, then press Mice Body restatement, and low dosage, middle dosage and high dose are respectively 20g crude drug amount/kg, 40g crude drug amount/kg and 80g crude drug amount/kg.
Select healthy mice 40, separate 10 at random and be only used as normal group, remaining 30 mice, is randomly divided into 3 groups: high dose group, middle dosage group, low dose group, and wherein 3 dosage groups are by above-mentioned dosage gastric infusion, normal group is to the water of 0.2ml, every morning 1 time, continuous 30d, after last gives experiment tested material 1 hour, take serum, measure SOD content in serum.
Antioxidative of the present invention impact ((X ± D)
* p < 0.05 is compared with normal group；* compares p < 0.01 with normal group
In the serum of of the present invention group of mice, SOD content is significantly higher than normal group, and has significant difference, illustrates that the present invention has antioxidation.
Claims (5)
1. a bee glue soft capsule, it is characterised in that its contained active component is extracted by following raw materials in part by weight medicine and is prepared from: propolis 2 parts, Herba Lobeliae taliensis 28 parts, dawrf mallow 16 parts, Radix Clerodendri Fortunati 22 parts, Herba Epilobii Angustifoii 18 parts, 5 parts of Radix Glycyrrhizae.
2. bee glue soft capsule as claimed in claim 1, it is characterized in that preparation process is: take Herba Lobeliae taliensis, dawrf mallow, Radix Clerodendri Fortunati, Herba Epilobii Angustifoii, licorice medicinal materials merging, boiling twice, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10-1.20, add ethanol, stirring, make alcohol content by volume percentage calculation reach 65-85%, stand, filter, filtrate reduced in volume is 1.20-1.30 to relative density when 65 DEG C and reclaims ethanol and obtain concentrated solution, concentrated solution is spray-dried, added the propolis powder of 60 mesh, add adjuvant and make soft capsule.
3. bee glue soft capsule as claimed in claim 2, it is characterised in that decocting condition is: amount of water is the 8-12 times amount of medical material weight for the first time, decocts 1-2h, and amount of water is the 6-10 times amount of medical material weight for the second time, decocts 1-2h.
4. bee glue soft capsule as claimed in claim 2, it is characterised in that described spray drying condition is: inlet temperature is 90-110 DEG C, and leaving air temp is 60-90 DEG C, and temperature of charge is 60-90 DEG C, and atomizing pressure is 0.2-0.5 MPa, and spray velocity is 1-10ml/s.
Bee glue soft capsule application in antioxidant health-care product the most according to claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610165075.4A CN105816576A (en) | 2016-03-19 | 2016-03-19 | Propolis soft capsules |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610165075.4A CN105816576A (en) | 2016-03-19 | 2016-03-19 | Propolis soft capsules |
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| CN105816576A true CN105816576A (en) | 2016-08-03 |
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| CN201610165075.4A Withdrawn CN105816576A (en) | 2016-03-19 | 2016-03-19 | Propolis soft capsules |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102138947A (en) * | 2011-03-28 | 2011-08-03 | 浙江省中医药研究院 | Propolis Chinese medicinal composition |
| CN102512456A (en) * | 2012-01-09 | 2012-06-27 | 浙江江山恒亮蜂产品有限公司 | Propolis soft capsule content and preparation method thereof |
-
2016
- 2016-03-19 CN CN201610165075.4A patent/CN105816576A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102138947A (en) * | 2011-03-28 | 2011-08-03 | 浙江省中医药研究院 | Propolis Chinese medicinal composition |
| CN102512456A (en) * | 2012-01-09 | 2012-06-27 | 浙江江山恒亮蜂产品有限公司 | Propolis soft capsule content and preparation method thereof |
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