CN102512456A - Propolis soft capsule content and preparation method thereof - Google Patents
Propolis soft capsule content and preparation method thereof Download PDFInfo
- Publication number
- CN102512456A CN102512456A CN2012100039746A CN201210003974A CN102512456A CN 102512456 A CN102512456 A CN 102512456A CN 2012100039746 A CN2012100039746 A CN 2012100039746A CN 201210003974 A CN201210003974 A CN 201210003974A CN 102512456 A CN102512456 A CN 102512456A
- Authority
- CN
- China
- Prior art keywords
- propolis
- soft capsule
- hydrophilic
- glycerol
- alcohol ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Jellies, Jams, And Syrups (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a propolis soft capsule content and a preparation method thereof. Propolis soft capsules are prepared by taking glycerol monooleate, glycerol and soyabean lecithin as a propolis carrier through the following steps of: preparing alcohol ester mixed solution; preparing alcohol ester propolis; cooling; preparing hydrophilic propolis liquid; preparing propolis soft capsules and the like. The propolis has high hydrophilicity; auxiliary materials with low safety such as polyethylene glycol and the like are not used; the glycerol monooleate, the glycerol and the soyabean lecithin are used as the propolis carrier; the strict national regulation on use of the health-care food raw materials at present is met; the product is stable; the safety is high; meanwhile, the hydrophilicity of the propolis is enhanced; and the absorption rate of a human body is increased.
Description
Technical field
The present invention relates to the content prescription and the method for preparing of bee glue soft capsule, belong to the processing technique of propolis.
Background technology
Propolis has been popular approval as a kind of healthy food material of obvious health-care efficacy, is that the health food of raw material has had nearly 300 kinds at present with the propolis.Dosage form has tablet, oral liquid, hard capsule, soft capsule etc., and is the most popular with soft capsule.
The prescription of bee glue product mainly contains three major types: be respectively with edible ethanol, Polyethylene Glycol, and Vegetable oil lipoprotein is a carrier.Being carrier with the edible ethanol, mainly is because edible ethanol has damage to liver, and some people is irritated to ethanol, and propolis can not long-term storage in ethanol, forms to cry easily on the package wall and gathers caffeinic atrament, causes product unstable, quality decline; Being carrier with the Polyethylene Glycol, mainly is that Polyethylene Glycol is the emulsifying agent of polyoxyethylene-type, makes propolis lose antibacterial action, not outside, Polyethylene Glycol generates harmful materials such as diethylene glycol easily in the course of processing; With the vegetable oil is the bee glue product of carrier, and hydrophilic is not enough, and propolis is insoluble in water, if propolis is not carried out hydrophilic treated, then human body has decline to the absorbance of propolis, and the vegetable oil long-term storage cause easily become sour rotten.According to market survey, what present most of hydrophilic propolis products used is that Polyethylene Glycol is solvent, can not all be scattered in water, has reduced the antibacterial effect of propolis, the safety existing problems of generation, and what have is cost with a large amount of losses of effective bee glue components.
The Chinese invention patent of inventor application, application number are 201010126306.3 to disclose a kind of content of hydrophilic bee glue soft capsule, adopt single caprylin as carrier, can make propolis be scattered in water equably, improve the absorbance of propolis in human body.Because single caprylin has stipulated in GB 2760 that its maximum in food is used and has limited the quantity of that therefore, when adding, can not use by the production requirement, there is certain limitation in percentage ratio that must its dosage of control.
Summary of the invention
The objective of the invention is to overcome the above-mentioned deficiency that exists in the prior art, and provide a kind of propolis that can make to be scattered in water equably, improve the absorbance of propolis in human body,
Do not reduce the propolis sterilizing function, and have content prescription and the method for preparing that the liver chemical injury is had the bee glue soft capsule of auxiliary protection, auxiliary hyperglycemic health care.
Overcome above-mentioned deficiency, and, satisfy the national at present strict regulations that use for healthy food material.Glyceryl monooleate, glycerol, three kinds of raw materials of soybean phospholipid are GB 2760 Table A .2 can be needed in an amount of food additive list that uses by production in varieties of food items, and product is stable, safe, increases the propolis hydrophilic simultaneously, improves the absorption by human body rate.
To achieve these goals, the present invention adopts following technical scheme:
A kind of bee glue soft capsule content comprises propolis and propolis carrier, it is characterized in that described propolis carrier is a glyceryl monooleate.The proportioning of propolis and glyceryl monooleate can be allocated with arbitrary proportion as required.
Said soft capsule content method for preparing is: it is earlier the propolis that is up to the standards to be pulverized; Sieve, after glyceryl monooleate is heated to 70 ℃-80 ℃, add the preprepared propolis; Constantly be stirred to propolis and all dissolve, get hydrophilic bee glue soft capsule content.Carry out the hydrophilic bee glue soft capsule content behind the mixing and emulsifying, recharge and process soft capsule.
Described carrier also comprises glycerol and soybean phospholipid.
The prescription of described propolis, glyceryl monooleate, glycerol and soybean phospholipid and weight ratio are propolis 1%-50%; Glyceryl monooleate 30%-80%; Glycerol 5%-25%; Soybean phospholipid 5%-50%.
Said soft capsule content method for preparing comprises:
(1) alcohol ester mixed liquor preparation: press the content prescription, glyceryl monooleate is dropped into stainless steel reaction bucket heating in water bath to 70 ℃-80 ℃, bath temperature can be 70 ℃-100 ℃; Add glycerol then, stir, mix; Make temperature of charge reach 70 ℃-80 ℃, obtain the alcohol ester mixed liquor.
(2) alcohol ester propolis liquid preparation: by prescription propolis is dropped in the alcohol ester mixed liquor, the reaction container bath temperature is 70 ℃-100 ℃, stirs, mixes, dissolves, and mixing speed does not limit, and dissolution time does not limit, to be dissolved as uniform working fluid degree of being.
(3) cooling: the alcohol ester propolis liquid is cooled to below 50 ℃.Method does not limit, and can perhaps emit the material natural cooling and all can through reducing the cooling effect of the cooling water pipe in reaction container bath temperature, the reaction container.Purpose: when preventing that next step from adding soybean phospholipid, Yin Wendu is too high and make the phospholipid degraded, loses activity.
(4) hydrophilic propolis liquid preparation: the soybean phospholipid input is cooled to the alcohol ester propolis liquid under 50 ℃, stirs, mix, up to forming uniform hydrophilic propolis liquid.
(5) preparation bee glue soft capsule: above-mentioned hydrophilic propolis liquid is filled and is processed soft capsule.Preparation technology can fill for propolis liquid of the prior art and process soft capsule technology.
It is carrier that prescription of the present invention adopts glyceryl monooleate, glycerol, soybean phospholipid; Propolis is dissolved in the phospholipid; And phospholipid is the good health care raw-food material, through glyceryl monooleate, glycerol carrier, propolis can be disperseed in water rapidly; All be scattered in water equably, improve the absorbance of propolis in human body.
Described propolis is for be crushed to the 40-60 order in advance, and 5 ℃ of following temperature are temporary.Refining propolis is pulverized, and purpose is in order to help the propolis dissolving, to shorten dissolution time, enhancing productivity.
It is carrier that the present invention adopts glyceryl monooleate, glycerol, soybean phospholipid, overcomes above-mentioned deficiency, and, satisfy the national at present strict regulations that use for healthy food material.Glyceryl monooleate, glycerol, three kinds of raw materials of soybean phospholipid are GB 2760 Table A .2 can be needed in an amount of food additive list that uses by production in varieties of food items, and product is stable, safe, increases the propolis hydrophilic simultaneously, improves the absorption by human body rate.
The present invention compared with prior art has the following advantages and effect:
Propolis good hydrophilic property of the present invention; Do not use not high adjuvant or the food additive of safety such as Polyethylene Glycol, do not use adjuvant or the food additive that reduces the propolis fungistatic effect, compare with oil-soluble propolis product; The human absorptivity is better, and health-care effect is more remarkable.
The present invention has adopted soybean phospholipid, has improved the propolis enhancing immunity, chemical liver injury has been had the health care of protective effect.
The propolis product that the present invention produces has adopted safe adjuvant: glyceryl monooleate, glycerol, soybean phospholipid; Its three kinds of raw materials are GB 2760 Table A .2 can be needed in an amount of food additive list that uses by production in varieties of food items; Product is stable, safe; Increase the propolis hydrophilic simultaneously, improve the absorption by human body rate.
The specific embodiment
Below in conjunction with embodiment the present invention is done further detailed description, following examples are to explanation of the present invention and the present invention is not limited to following examples.
Embodiment 1:
A kind of bee glue soft capsule content comprises propolis, glyceryl monooleate, glycerol and soybean phospholipid, and its prescription and weight ratio are propolis 1%-50%; Glyceryl monooleate 30%-80%; Glycerol 5%-25%; Soybean phospholipid 5%-50%.For example: propolis 1.2%; Glyceryl monooleate 70%; Glycerol 8.8%; Soybean phospholipid 20%.For example: propolis 8%; Glyceryl monooleate 77%; Glycerol 7%; Soybean phospholipid 8%.For example: propolis 45%; Glyceryl monooleate 32%; Glycerol 16%; Soybean phospholipid 7%.For example: propolis 16%; Glyceryl monooleate 31%; Glycerol 6%; Soybean phospholipid 47%.For example: propolis 9%; Glyceryl monooleate 50%; Glycerol 23%; Soybean phospholipid 18%.
Embodiment 2:
The present invention comprises formula for a product, raw material examination, the preparation of alcohol ester mixed liquor, the preparation of alcohol ester propolis liquid, cooling, the preparation of hydrophilic propolis liquid successively, changes glue, filled capsules, finalizes the design, washes ball, drying, inspection ball, packing, product inspection and warehouse-in.
At first, according to formula for a product raw material is carried out an acceptance inspection, with edible ethanol propolis raw material is made with extra care purification, in 0-5 ℃ propolis is crushed to the 40-60 order with beater grinder, 5 ℃ of following temperature are temporary;
Alcohol ester mixed liquor preparation then: press the content prescription, glyceryl monooleate is dropped into stainless steel reaction bucket heating in water bath to 70 ℃-80 ℃, bath temperature can be 70 ℃-100 ℃; Add glycerol then, stir, mix; Make temperature of charge reach 70 ℃-80 ℃, obtain the alcohol ester mixed liquor;
The preparation of alcohol ester propolis liquid: the propolis powder of pressing after prescription will be pulverized drops in the alcohol ester mixed liquor, and the reaction container bath temperature is 70 ℃-100 ℃, stirs, mixes, dissolves, and mixing speed does not limit, and dissolution time does not limit, and is dissolved as uniform working fluid and gets final product;
Cooling:, the alcohol ester propolis liquid is cooled to below 50 ℃ through reducing the cooling effect of the cooling water pipe in reaction container bath temperature, the reaction container.
Hydrophilic propolis liquid preparation: the soybean phospholipid input is cooled to the alcohol ester propolis liquid below 50 ℃, stirs, mix, up to forming uniform hydrophilic propolis liquid.
Above-mentioned operation just obtains the semi-finished product propolis liquid after finishing, and next just the semi-finished product propolis liquid is carried out the intermediate products check.
Next being glue, with gelatin, glycerol, water-solubleization, and vacuum is taken out superfluous water; Obtain the gelatin solution of certain viscosity and moisture; Then qualified semi-finished product propolis liquid is filled soft capsule, the soft capsule content specification is the 400-800mg/ grain, also can be as required.Finalize the design, wash series of processes such as ball, drying, the check of inspection ball intermediate products again, the semi-finished product that are up to the standards just become finished product through packing, at last finished product are carried out product inspection, and qualified finished product just can have been put in storage.Propolis among the present invention extracts, changes glue, filled capsules, finalizes the design, washes ball, drying, the check of inspection ball intermediate products, packing, product inspection and warehouse-in operation, and is all identical with prior art.
Embodiment 3: a kind of bee glue soft capsule content, comprise propolis, glyceryl monooleate, and its prescription and weight ratio are propolis 1%; Glyceryl monooleate 99%; Perhaps propolis 10%; Glyceryl monooleate 90%; Perhaps propolis 30%; Glyceryl monooleate 70%; Perhaps propolis 50%; Glyceryl monooleate 50%; Perhaps propolis 60%; Glyceryl monooleate 40%; Perhaps propolis 80%; Glyceryl monooleate 20%; Perhaps propolis 90%; Glyceryl monooleate 10%; Perhaps propolis 95%; Glyceryl monooleate 5%.
Embodiment 4:
Be ready to propolis 60%, glyceryl monooleate 40%.Earlier the propolis that is up to the standards is pulverized, sieved, glyceryl monooleate constantly is stirred to propolis and all dissolves after being heated to 75 ℃-80 ℃, gets hydrophilic bee glue soft capsule content.Carry out the hydrophilic bee glue soft capsule content behind the mixing and emulsifying, recharge and process soft capsule.Filling is processed the method for soft capsule with embodiment 2.
In addition, need to prove, allly conceive equivalence or the simple change that described formula for a product, preparation technology, characteristic and principle are done, include in the protection domain of patent of the present invention according to patent of the present invention.
Claims (7)
1. a bee glue soft capsule content comprises propolis and propolis carrier, it is characterized in that described propolis carrier is a glyceryl monooleate.
2. a kind of bee glue soft capsule content according to claim 1 is characterized in that described carrier also comprises glycerol and soybean phospholipid.
3. a kind of bee glue soft capsule content according to claim 2 is characterized in that the prescription of described propolis, glyceryl monooleate, glycerol and soybean phospholipid and weight ratio are propolis 1%-50%; Glyceryl monooleate 30%-80%; Glycerol 5%-25%; Soybean phospholipid 5%-50%.
4. the method for preparing of a kind of bee glue soft capsule content according to claim 1; After it is characterized in that described glyceryl monooleate is heated to 70 ℃-80 ℃; Add the preprepared propolis, constantly be stirred to propolis and all dissolve, get hydrophilic bee glue soft capsule content.
5. according to the method for preparing of claim 2 or 3 described a kind of bee glue soft capsule contents, it is characterized in that comprising the steps:
(1) alcohol ester mixed liquor preparation: press the content prescription, glyceryl monooleate is dropped into stainless steel reaction bucket heating in water bath to 70 ℃-80 ℃, add glycerol then, stir, mixing makes temperature of charge reach 70 ℃-80 ℃, obtains the alcohol ester mixed liquor;
(2) alcohol ester propolis liquid preparation: by prescription propolis is dropped in the alcohol ester mixed liquor, the reaction container bath temperature is 70 ℃-100 ℃, stirs, mixes, dissolves, and is dissolved as uniform working fluid and gets final product;
(3) cooling: the alcohol ester propolis liquid is cooled to below 50 ℃;
(4) hydrophilic propolis liquid preparation: the soybean phospholipid input is cooled to the alcohol ester propolis liquid under 50 ℃, stirs, mix, up to forming uniform hydrophilic propolis liquid;
(5) preparation bee glue soft capsule: above-mentioned hydrophilic propolis liquid is filled and is processed soft capsule.
6. the content method for preparing of a kind of hydrophilic bee glue soft capsule according to claim 4 is characterized in that described propolis for being crushed to the 40-60 order in advance, and 5 ℃ of following temperature are temporary.
7. the content method for preparing of a kind of hydrophilic bee glue soft capsule according to claim 5 is characterized in that described propolis for being crushed to the 40-60 order in advance, and 5 ℃ of following temperature are temporary.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100039746A CN102512456A (en) | 2012-01-09 | 2012-01-09 | Propolis soft capsule content and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100039746A CN102512456A (en) | 2012-01-09 | 2012-01-09 | Propolis soft capsule content and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102512456A true CN102512456A (en) | 2012-06-27 |
Family
ID=46283710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100039746A Pending CN102512456A (en) | 2012-01-09 | 2012-01-09 | Propolis soft capsule content and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102512456A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103005250A (en) * | 2012-12-10 | 2013-04-03 | 杭州蜂之语蜂业股份有限公司 | Preparation process of propolis solution |
| CN105816576A (en) * | 2016-03-19 | 2016-08-03 | 李正梅 | Propolis soft capsules |
| CN108703955A (en) * | 2018-07-31 | 2018-10-26 | 荆楚理工学院 | A kind of minerals soft capsule and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004091392A (en) * | 2002-08-30 | 2004-03-25 | Biomedeikusu:Kk | Sparingly water-soluble component-containing composition for dispersion in water and beverage |
| CN101019833A (en) * | 2007-02-16 | 2007-08-22 | 鲁传华 | Oil-in-oil nonaqueous microemulsion used as medicine carrier and its medicine prepn |
| CN101791076A (en) * | 2010-03-17 | 2010-08-04 | 浙江江山恒亮蜂产品有限公司 | Recipe of hydrophilic proplis soft capsule content and preparation method thereof |
-
2012
- 2012-01-09 CN CN2012100039746A patent/CN102512456A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004091392A (en) * | 2002-08-30 | 2004-03-25 | Biomedeikusu:Kk | Sparingly water-soluble component-containing composition for dispersion in water and beverage |
| CN101019833A (en) * | 2007-02-16 | 2007-08-22 | 鲁传华 | Oil-in-oil nonaqueous microemulsion used as medicine carrier and its medicine prepn |
| CN101791076A (en) * | 2010-03-17 | 2010-08-04 | 浙江江山恒亮蜂产品有限公司 | Recipe of hydrophilic proplis soft capsule content and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 周萍，等: "三种蜂胶软胶囊辅料浅析", 《养蜂科技》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103005250A (en) * | 2012-12-10 | 2013-04-03 | 杭州蜂之语蜂业股份有限公司 | Preparation process of propolis solution |
| CN103005250B (en) * | 2012-12-10 | 2014-04-16 | 杭州蜂之语蜂业股份有限公司 | Preparation process of propolis solution |
| CN105816576A (en) * | 2016-03-19 | 2016-08-03 | 李正梅 | Propolis soft capsules |
| CN108703955A (en) * | 2018-07-31 | 2018-10-26 | 荆楚理工学院 | A kind of minerals soft capsule and preparation method thereof |
| CN108703955B (en) * | 2018-07-31 | 2020-02-21 | 荆楚理工学院 | Mineral soft capsule and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102283386B (en) | Composite camellia oil health care product with function of reducing blood fat and preparation method thereof | |
| CN103222619A (en) | Five cereal health preserving powder | |
| CN104673546A (en) | Camellia oil handmade soap | |
| CN104322702A (en) | Granule-suspended peanut milk beverage and preparation method thereof | |
| CN106727675A (en) | A kind of calcium-replenishing soft capsule and preparation method thereof | |
| CN102512456A (en) | Propolis soft capsule content and preparation method thereof | |
| CN103815395A (en) | Propolis-safflower oil soft capsule and preparation method thereof | |
| CN102552732B (en) | Chinese medicinal preparation or Chinese medicinal health care product with effect of reducing blood fat | |
| CN106590998A (en) | Green tea cold prepared handmade soap and preparation method thereof | |
| CN106387255A (en) | Sokmak and making method thereof | |
| CN102669682B (en) | Selenium-enriched nutrient yeast food and production method thereof | |
| CN101940316B (en) | Canned porridge and production method thereof | |
| CN106344626A (en) | Preparation method of sulforaphane soft capsules | |
| CN105154258A (en) | Tea tree, Binchotan and mare milk soap | |
| CN104489444A (en) | Propolis-royal jelly soft capsule | |
| CN103652924B (en) | A kind of compound grape-seed fat capsule and preparation method thereof | |
| CN104711197A (en) | Tabletted or capsulated mother seed medium production technology and application method thereof | |
| CN104000275B (en) | Spearmint essential oil microemulsion formula used for beverage anticorrosion and preparation method thereof | |
| RU2536581C1 (en) | Method for manufacture of instant food products based on sprouted cereals | |
| CN101791076B (en) | Recipe of hydrophilic proplis soft capsule content and preparation method thereof | |
| CN104171207A (en) | Hangover-alleviating tea and preparation method thereof | |
| CN107969688A (en) | A kind of soft capsule of lycopene and its production technology | |
| CN1965813B (en) | Compound soft capsule of propolis | |
| CN107048290A (en) | A kind of preparation method of nutrient fruit cream | |
| CN103948606B (en) | Akafen powder and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120627 |