CN105814124B - 生产干纤维素醚基泡沫的低温方法 - Google Patents

生产干纤维素醚基泡沫的低温方法 Download PDF

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CN105814124B
CN105814124B CN201480064175.7A CN201480064175A CN105814124B CN 105814124 B CN105814124 B CN 105814124B CN 201480064175 A CN201480064175 A CN 201480064175A CN 105814124 B CN105814124 B CN 105814124B
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J·L·柯蒂斯-菲斯克
P·J·希斯凯
M·布克曼
A·C·基南
K·乔希
J·A·托马斯
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Rohm and Haas Co
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Abstract

本发明提供一种包含胶凝剂的组合物。所述胶凝剂基本上由纤维素醚基胶凝聚合物组成并且所述组合物在约20摄氏度下是硬质泡沫。组合物还可以包含活性成分。还提供一种制备组合物的方法，所述方法包含将含有胶凝剂的起泡液体组合物在低温下干燥。所述起泡液体组合物还可以包含活性成分。

Description

生产干纤维素醚基泡沫的低温方法
相关申请的交叉参考
本申请主张2013年11月27日提交的美国临时申请第61/909,889号的优先权，所述临时申请的公开内容通过引用以其全文结合在此。
技术领域
本发明涉及泡沫组合物和制备所述组合物的方法。
背景技术
在个人护理行业中，可以通过将活性成分配制成乳膏或洗剂、然后涂覆于皮肤上来将活性成分以皮肤疗法传递。有时难以将足够的活性成分装载于有效的稳定配制品中或将活性成分自配制品传递到皮肤上。因此活性成分不能有效地用于皮肤上。举例来说，在活性成分存在于护肤产品(例如洗剂)中的组合物中，治疗部位涂覆的洗剂可能不足以产生益处。
另外，个人护理行业中所用的活性成分往往对温度敏感。植物学产品可能尤其难以调配，原因在于大部分植物学产品对热敏感并且溶解度和稳定性较低。将不相容活性成分(例如疏水性组分和亲水性组分)加入配制品中也是理想的。此外，虽然可以将活性成分并入水溶性膜中，但是这些膜需要在水中操作，以便这些膜在涂覆之前溶解。因此，如果使用的水太多，那么活性成分会变得太稀，或者，如果使用的水不够，那么膜不会完全溶解以释出活性成分。
因此，需要一种稳定配制品，这种配制品能够合并热敏性活性成分并且可以确保活性成分靶向传递到所要位置。这种配制品可以适用于需要靶向传递的许多行业，包括(但不限于)个人护理和洗衣/去污应用。
发明内容
在一个方面中，提供包含胶凝剂的组合物。胶凝剂主要由纤维素基胶凝聚合物组成，其中所述纤维素基胶凝聚合物在2％溶液中、在约20摄氏度下具有约2厘泊(centipoise)与约4000厘泊之间的粘度。组合物在约20摄氏度下可以是硬质泡沫。组合物还可以包含活性成分。
在另一方面中，提供制备这种组合物的方法。所述方法包含将包含胶凝剂的起泡液体组合物在约40摄氏度与约50摄氏度之间的温度下干燥约10分钟与约30分钟之间。起泡液体组合物还可以包含活性成分。
具体实施方式
为了确保活性成分的适当安置和投配，使充气泡沫快速溶解是有益的。靶向传递需要轻质、稳定的配制品。还需要使活性成分维持稳定状态，而无需为了获得长存放期去研发复杂配方。
可以通过将活性成分和胶凝剂(例如纤维素基胶凝聚合物)的起泡液体混合物干燥来产生用于传递个人护理活性成分的快速溶解型固体剂型。本发明提供包含胶凝剂的组合物。组合物还可以包含活性成分。胶凝剂可以主要由纤维素基胶凝聚合物组成，其中所述纤维素基胶凝聚合物在2重量％溶液中、在约20摄氏度下的粘度是在约2厘泊(cP)与约4000厘泊之间，优选的是在约2cP与约100cP之间，并且更优选的是在约2cP与约10cP之间。举例来说，纤维素基胶凝聚合物可以是羟丙基甲基纤维素(hydroxypropyl methylcellulose；HPMC)、甲基纤维素或其组合。举例来说，在一些实施例中，纤维素基胶凝聚合物在2重量％溶液中、在约20摄氏度下可以具有约6cP的粘度。在其它实施例中，纤维素基胶凝聚合物在2重量％溶液中、在约20摄氏度下可以具有约2.5cP的粘度。纤维素基胶凝聚合物可以是组合物中所用的唯一胶凝剂。举例来说，组合物可以仅包含HPMC而不包含其它胶凝剂。在其它实施例中，组合物可以仅包含甲基纤维素或HPMC和甲基纤维素。
将气体(例如空气)并入溶液中使得所产生固体的孔隙率和表面积增大，这是液体快速进入固体并且溶解所述物质的关键特征。组合物可以包含约20体积％与约99体积％之间的空气，并且优选的是约30体积％与约70体积％之间的空气。所要空气量可以是应用专用的量。举例来说，如果需要更多的硬质泡沫，那么含有较少空气可能是理想的。空气的量也可以和所用活性成分的组成有关。举例来说，当活性成分是固体颜料时，可能需要包括更多的空气。在一些实施例中，组成可以包含约50体积％空气和50体积％组合物。
组合物能够快速溶解或分散以便使活性成分得到快速传递。举例来说，组合物可以在搅拌下、在约10秒内分散于水中。在一些实施例中，组合物可以用于将活性成分提供到目标，例如皮肤。举例来说，这些组合物可以用于免洗式护肤治疗，包括(但不限于)医药治疗、化妆品、洗剂、痤疮治疗和维生素C治疗。在其它实施例中，这些组合物可以用于冲洗式产品，包括(但不限于)洗发精、沐浴露、剃须膏和面部清洁剂。在其它实施例中，组合物可以用于提供清洁(例如在洗衣应用中)和去污所用的活性成分。组合物也可以崩解(即，分裂成小碎片)而无需使用水。举例来说，为了吸收毛发中的油，将油吸收剂(例如玉米淀粉)作为活性成分加入组合物中可为理想的。
胶凝剂可以在加热时经历快速热胶凝，从而允许泡沫在干燥过程中维持其结构并且容纳所悬浮的固体。由此产生的固体泡沫在机械完整性上大于溶液冻干并且孔隙率大于膜条带，溶液冻干和膜条带是例如医药行业中生产这种类型产品常用的两种替代途径。组合物在室温(约20摄氏度)下可以是硬质泡沫。因此，组合物可以适用于多种应用中的单独封装和储存。
还公开一种制备本发明组合物的方法。所述方法包含将包含胶凝剂的起泡液体组合物在约40摄氏度与约50摄氏度之间的温度下干燥。起泡液体组合物还可以包含活性成分。液体组合物可以干燥例如约10分钟与约30分钟之间。举例来说，在一些实施例中，如果需要的泡沫组合物更少，那么干燥时间更快。特定来说，所述方法不需要表面活性剂的存在，使得组合物不含或基本上不含表面活性剂。在其它实施例中，可以在工艺过程中将表面活性剂加入组合物中。使用表面活性剂可以有助于产生泡沫或可以将表面活性剂作为活性成分加入。
低温胶凝水溶性甲基纤维素和HPMC聚合物的胶凝过程是在室温下开始，并且一旦胶凝化，那么所产生的泡沫在干燥期间保持结构。这种方法可以在比挤出(生产干燥固体泡沫组合物的一种替代方法)所需低得多的温度下进行。这对于不能经受住高温工艺(例如挤出)的温度敏感性活性成分来说可能特别有益。举例来说，活性成分在高温下可能容易发生降解。在一些实施例中，在高于50摄氏度下展示降解的活性成分能经受住所述方法。活性成分可以是例如颜料、维生素C、增湿剂、痤疮治疗剂，或植物学产品，例如芦荟(aloe vera)或茶树油。在其它实施例中，活性成分可以是清洁剂，例如个人护理清洁剂(例如洗发精、沐浴露、面部清洁剂)或家用清洁(例如洗衣)所用的清洁剂。
实例
通过使HPMC(并且在一些实例中，活性成分)的水溶液或悬浮液起泡来制备干泡沫。表1所示的实例中使用50％泡沫品质(50体积％空气、50体积％配制品)，但30体积％与70体积％之间的空气也展现泡沫品质，同时仍然生产出高品质产品，即，孔隙率高并且能够快速和准确传递活性成分的硬质泡沫。将泡沫滴落到不粘的烘焙薄板上并且在50℃干燥20分钟。组合物配方展示于下表1中。这些配方产生能够快速并且准确传递活性成分到目标的硬质泡沫。
表1.实例配方
Figure BDA0000998210530000031
Figure BDA0000998210530000041
在实例1、实例2、实例4和实例5中，塑化剂是用于防止组合物发脆以及保持泡沫结构。在实例3中，表面活性剂是用作洗发精应用中的发泡剂。然而，不需要表面活性剂来产生硬质配制品，这意味着唯一胶凝剂是HPMC。在实例4中，玉米淀粉用作油吸收剂以产生“干式”洗发精，其无需水便可崩解。
虽然本发明已经根据其优选实施例描述如上，但可以在本发明的精神和范围内加以润饰。因此，本申请希望涵盖使用本文所公开的一般原理对本发明进行的的任何变化、使用或修改。另外，本申请希望涵盖出现于本发明所涉及领域中已知或习惯做法中并且处于随附权利要求书界限内的相对于本发明的背离。

Claims (10)

1.一种干泡沫组合物，包含∶
20体积％-99体积％的空气，
活性成分，
胶凝剂，其中所述胶凝剂由纤维素基胶凝聚合物组成，所述纤维素基胶凝聚合物选自羟丙基甲基纤维素、甲基纤维素或其组合，
其中所述纤维素基胶凝聚合物在2重量％溶液中、在20摄氏度下具有2厘泊与100厘泊之间的粘度。
2.根据权利要求1所述的组合物，其中所述纤维素基胶凝聚合物具有2厘泊与10厘泊之间的粘度。
3.根据权利要求1或权利要求2所述的组合物，其中所述组合物在搅拌下能在10秒内分散于水中。
4.根据权利要求1或权利要求2所述的组合物，其中所述组合物无需使用水便可崩解。
5.根据权利要求1或权利要求2所述的组合物，其中所述活性成分在高于50摄氏度的温度下容易降解。
6.根据权利要求1或权利要求2所述的组合物，其中所述活性成分是维生素C、植物学产品或颜料。
7.根据权利要求1或权利要求2所述的组合物，其中所述组合物包含30体积％与70体积％之间的空气。
8.一种制备根据权利要求1所述的组合物的方法，所述方法包含∶
将包含所述胶凝剂的起泡液体组合物在40摄氏度与50摄氏度之间的温度下干燥。
9.根据权利要求8所述的方法，其中所述起泡液体组合物干燥10分钟与30分钟之间。
10.根据权利要求8或权利要求9所述的方法，其中所述方法不需要表面活性剂的存在。
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