CN105800105A - Chemiluminescence immunoassay system and sample and reagent storage plate thereof - Google Patents
Chemiluminescence immunoassay system and sample and reagent storage plate thereof Download PDFInfo
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- CN105800105A CN105800105A CN201510717577.9A CN201510717577A CN105800105A CN 105800105 A CN105800105 A CN 105800105A CN 201510717577 A CN201510717577 A CN 201510717577A CN 105800105 A CN105800105 A CN 105800105A
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- chemiluminescence immunoassay
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/08—Materials, e.g. different materials, enclosed in separate compartments formed during filling of a single container
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a chemiluminescence immunoassay system and a sample and reagent storage plate thereof. A plate body of the sample and reagent storage plate is provided with an outer ring containing groove and an inner ring containing groove so that sample pipes and reagent pipes can be contained. By designing the sample and reagent storage plate in an optimized manner, the space, occupied by samples and reagents, of a host is reduced, compactness of the structure of the host is improved, the sample and reagent storing and taking efficiency is improved, and the automation degree of the chemiluminescence immunoassay system is improved.
Description
Technical field
The present invention relates to immunoassay diagnostic techniques field, particularly to a kind of chemiluminescence immunoassay system and sample reagent tray thereof.
Background technology
Chemiluminescence immunoassay system and chemical illumination immunity analysis instrument device, utilize the equipment carrying out immunoassay of the direct labelled antigen of chemiluminescence agent or antibody.Automatic chemiluminescence immunoassay equipment is widely used in clinical immunization technology, has environmental protection, fast and accurately feature.
In prior art, specimen disc and reagent disc in chemiluminescence immunoassay system are respectively arranged in main frame, namely sample arm device is installed between the two, by rotary sample addition arm assembly, make the relevant position of its sample needle counter sample dish and reagent disc, again through lifting sample arm device, the formulation sample of position, reagent are picked and placeed action.
When needing to pick and place the sample of other positions, reagent, it is necessary to rotate specimen disc and reagent disc respectively so that it is arrive the lower position of sample needle, in order to accurately obtain sample and reagent.But, when adopting specimen disc and the reagent disc of said structure, take hosting space relatively big, and complex operation, picking and placeing sample and reagent efficiency is low, automaticity is low.
In view of this, it would be highly desirable to for the problems referred to above, the structure of specimen disc and reagent disc is optimized design, take hosting space to effectively reduce, and raising picks and places sample and reagent efficiency, improves the automaticity of chemiluminescence immunoassay system.
Summary of the invention
The purpose of the present invention is for providing the sample reagent tray of a kind of chemiluminescence immunoassay system, by optimizing design sample reagent storage dish, reduction sample and reagent take the space of main frame, promote the compactedness of main machine structure, and improve the automaticity of access sample, the efficiency of reagent and chemiluminescence immunoassay system.On this basis, another object of the present invention is for providing a kind of chemiluminescence immunoassay system with this sample reagent tray.
The present invention provides the sample reagent tray of a kind of chemiluminescence immunoassay system, and the disk body of described sample reagent tray is provided with outer ring mounting groove and inner ring mounting groove, to hold sample cell and Reagent Tube respectively.
Alternatively, described outer ring mounting groove and described inner ring mounting groove are all arranged concentrically with described disk body.
Alternatively, described outer ring mounting groove includes multiple arcuate groove and the arc-shaped seat of the notch outer rim being stuck in described arcuate groove, and described arc-shaped seat offers the circular hole of multiple coupling sample cell；Described inner ring mounting groove arranges multiple and described Reagent Tube placed hole one to one.
Alternatively, described disk body is hollow-core construction.
Alternatively, described sample reagent tray is provided with the installing hole of the sample arm device of fixing described chemiluminescence immunoassay system.
Alternatively, the periphery of described disk body is provided with arc notch, and the arc perisporium of the reaction tray of described chemiluminescence immunoassay system inserts described arc notch.
Alternatively, the bottom of described disk body is provided with fixed supporting leg, and described fixed supporting leg is fixedly supported to the main frame of described chemiluminescence immunoassay system.
Alternatively, the bottom of described disk body is provided with refrigerating plant, with to the reagent refrigerating thermal-insulation in described Reagent Tube.
In a kind of preferred version provided by the invention, the disk body of the sample reagent tray of this chemiluminescence immunoassay system is provided with outer ring mounting groove and inner ring mounting groove, and namely two mounting grooves are all circumferentially disposed along disk body, the center of disk body be arranged in order to periphery.So, can sample cell and Reagent Tube be all placed on this disk body, thus specimen disc and reagent disc are integrated in one, simplify and install, improve the compactedness of chemiluminescence immunoassay system, and, it is possible to sample cell and Reagent Tube one_to_one corresponding are laid, it is easy to pick and place sample and reagent, improves work efficiency.
The present invention also provides for a kind of chemiluminescence immunoassay system, disk body including sample arm device and storing samples, reagent, described sample arm device includes the vertical drive division of circumferential drive division and the vertically movement driving the sample needle circumference of described sample arm device to move, also including the radial drive portion driving the sample needle of described sample arm device to move radially, described disk body adopts samples described above reagent storage dish；Described sample arm device is placed in the middle part of described sample reagent tray.
Alternatively, described radial drive portion includes,
Guide, the direction of stretching out along the sample arm of described sample arm device is arranged；
Guide block, the sample needle of the described sample arm device that is connected, the described guide described guide block of guiding slides；With
Power source, drives described guide block to move back and forth along described guide.
Alternatively, described guide is the guide rail or guide post that mate with described guide block.
Alternatively, described sample arm is provided with the separator tube being fixed on described guide block, and described sample needle is installed on described separator tube.
Alternatively, described sample arm device is provided with ball spline shaft and is placed on the hub splines of described ball spline shaft, the sample arm of described sample arm device is fixed on the top of described ball spline shaft, the circumferential drive motor of described circumference drive division drives described hub splines to drive described ball spline shaft to rotate, and the vertical drive motor of described vertical drive division drives described ball spline shaft vertically to move relative to described hub splines.
A kind of preferred version in the present invention, this chemiluminescence immunoassay system adopts above-mentioned sample reagent tray, and, for this sample reagent tray, sample arm device is set, this sample arm device sets up radial drive portion, thus sample needle moving radially along disk body can be driven, picks and places the respective sample pipe and Reagent Tube that are placed in outer ring mounting groove and inner ring mounting groove, promote the automaticity of chemiluminescence immunoassay system, improve work efficiency.
Owing to above-mentioned sample reagent tray has above technique effect, therefore, the chemiluminescence immunoassay system applying this sample reagent tray should also be as having identical technique effect, does not repeat them here.
Accompanying drawing explanation
Fig. 1 is the structural representation of sample reagent tray in specific embodiment；
Fig. 2 is the structural representation of arc-shaped seat in specific embodiment；
Fig. 3 is the structural representation of sample arm device in specific embodiment；
Fig. 4 is the structural representation of chemiluminescence immunoassay system in specific embodiment.
Wherein, the corresponding relation between accompanying drawing labelling and the component names in Fig. 1 to Fig. 4 is:
Sample reagent tray 10；
Disk body 11, outer ring mounting groove 12, inner ring mounting groove 13, installing hole 14, fixed supporting leg 15, refrigerating plant 16, arc-shaped seat 121, circular hole 1211；
Reaction tray 20；
Sample arm device 30；
Sample needle 31, sample arm 32, guide 33, guide block 34, power source 35, separator tube 36, ball spline shaft 37, hub splines 38, circumference drive motor 39-1, vertical drive motor 39-2；
Sample cell 40, Reagent Tube 50.
Detailed description of the invention
The core of the present invention is for providing the sample reagent tray of a kind of chemiluminescence immunoassay system, and by optimizing sample reagent tray, reduction sample and reagent take the space of main frame, promote the compactedness of main machine structure；And coordinate sample arm device, improve the efficiency of access sample, reagent, it is achieved the automaticity of chemiluminescence immunoassay system.On this basis, another object of the present invention is for providing a kind of chemiluminescence immunoassay system with this sample reagent tray.
In order to make those skilled in the art be more fully understood that technical scheme, below in conjunction with the drawings and specific embodiments, the present invention is described in further detail.
Refer to shown in Fig. 1 and Fig. 2, Fig. 1 is the structural representation of sample reagent tray in specific embodiment；Fig. 2 is the structural representation of arc-shaped seat in specific embodiment.
The present invention provides the sample reagent tray 10 of a kind of chemiluminescence immunoassay system, and the disk body 11 of its circle is provided with outer ring mounting groove 12 and inner ring mounting groove 13, is respectively used to hold sample cell 40 and Reagent Tube 50.
In a kind of detailed description of the invention, as it is shown in figure 1, the outer ring mounting groove 12 arranged on disk body 11 and inner ring mounting groove 13 all circumferentially disposed along disk body 11, both are arranged in order to periphery by the center of disk body 11.Specifically, the outer ring mounting groove 12 of disk body 11 is used for holding sample cell 40, inner ring mounting groove 13 for holding Reagent Tube 50, adapts to sample cell 40 and changes, picks and places the feature that frequency is high, it is simple to operation.
So, can sample cell 40 and Reagent Tube 50 be all placed on this disk body 11, thus specimen disc and reagent disc are integrated in one, simplify and install, improve the compactedness of chemiluminescence immunoassay system, and, it is possible to sample cell 40 and Reagent Tube 50 one_to_one corresponding are laid, it is easy to pick and place sample and reagent, improves work efficiency.
Outer ring mounting groove 12 holds sample cell 40 in a particular embodiment, inner ring mounting groove 13 holds Reagent Tube 50, certainly, it is possible to be used for holding Reagent Tube 50, inner ring mounting groove 13 for holding sample cell 40 by outer ring mounting groove 12.Only both need to be made to adapt with the object held, allow it to reliably be positioned on disk body 11.
Outer ring mounting groove 12 and inner ring mounting groove 13 are all arranged concentrically with disk body 11, it is possible to optimize the structure of sample reagent tray 10, promote its compactedness.
Further, outer ring mounting groove 12 includes multiple arcuate groove and the arc-shaped seat 121 of the notch outer rim being stuck in arcuate groove, and meanwhile, arc-shaped seat 121 offers the circular hole 1211 of multiple coupling sample cell 40；So, sample cell 40 can be inserted in circular hole 1211 fixing, then arc-shaped seat 121 is stuck in the notch of arcuate groove, in order to frequently picking and placeing of sample cell 40.Multiple arcuate groove and arc-shaped seat 121 coupling is utilized to form outer ring mounting groove 12, it is possible to lay specific sample cell 40 in groups, it is simple to exact operations.Please also refer to shown in Fig. 1 and Fig. 2.
Specifically, circular hole 1211 arranges two rows, and in two rows, adjacent circular hole 1211 is crisscross arranged, in order to picking and placeing of sample cell 40, evades interference each other.
And inner ring mounting groove 13 arranges multiple with Reagent Tube 50 placed hole one to one, so, in order to pick and place specific separate agent pipe 50.
In order to save material, reducing the overall weight of chemiluminescence immunoassay system, convenient carry, its disk body 11 is set to hollow-core construction.
Further, its sample reagent tray 10 is provided with the installing hole 14 of fixing sample arm device 30, thus sample arm device 30 can be installed on sample reagent tray 10, evade sample arm device 30 and be independently arranged and take bigger hosting space, promote integrally-built compactedness.
For above-described embodiment, disk body 11 shape is designed further.Specifically as shown in Figure 1 and Figure 4.The periphery of disk body 11 is provided with arc notch, this arc notch can install, for the reaction tray 20 of chemiluminescence immunoassay system, the space providing certain, namely when mounted, the circle at disk body 11 place intersects with the circle at reaction tray 20 place so that the arc perisporium of reaction tray 20 be able to insert arc notch.
So arrange, it is possible to optimize the layout of each component in main frame further, improve its compactedness, for providing a kind of small-sized chemiluminescence immunoassay system to provide safeguard.
Further, the bottom of disk body 11 is provided with fixed supporting leg 15, and fixed supporting leg 15 is fixedly supported to the main frame of chemiluminescence immunoassay system.Specifically, fixed supporting leg 15 arranges four fixed supporting legs 15 and is distributed in the bottom of disk body 11, thus reliable and stable support disk body 11, and it is fixed in main frame.
It should be noted that the quantity of fixed supporting leg 15 is not limited to four, also can set as desired, only need can stably support disk body 11, sample reagent tray 10 is fixed on main frame.Therefore, the technical scheme that the application is not claimed by the particular number of fixed supporting leg 15 is construed as limiting.
The bottom of disk body 11 is additionally provided with refrigerating plant 16, as it can be seen, refrigerating plant 16 is arranged at the side of the cell body placing Reagent Tube 50, for Reagent Tube 50 is carried out refrigerating thermal-insulation.
It is additionally provided with the code reader for manual scanning sample bar code, thus sample cell 40 is labeled.
Except above-mentioned sample reagent tray 10, the present invention also provides for a kind of chemiluminescence immunoassay system, and including sample arm device 30, this sample arm device 30 includes the vertical drive division of circumferential drive division and the vertically movement driving sample needle 31 circumference movement；Unlike the prior art, this chemiluminescence immunoassay system adopts above-mentioned sample reagent tray 10, and meanwhile, sample arm device 30 also includes the radial drive portion driving sample needle 31 to move radially；And, sample arm device 30 is placed in the middle part of sample reagent tray 10.
So arrange, the adaptive sample reagent tray 10 of sample arm device 30, rotate in a circumferential direction motion, vertical direction motion, radial direction stretching motion can be carried out when making sample needle 31 pick and place sample reagent, and sample reagent tray 10 maintains static, effectively evade manual operation and rotate specimen disc and the individual variation of reagent disc appearance, realize the full-automation of chemiluminescence immunoassay system, effectively eliminate the error that manual operation produces.
In conjunction with shown in Fig. 3 and Fig. 4, above-mentioned radial drive portion includes guide 33, guide block 34 and power source 35, wherein, guide 33 is arranged along the direction of stretching out of the sample arm 32 of sample arm device 30, guide block 34 is for fixing the sample needle 31 of sample arm device 30, and guide block 34 coordinates with guide 33, makes guide block 34 can slide along guide 33, so that sample needle 31 is close, support movement away from sample arm device 30, also allows for sample needle 31 and move along the radial direction of disk body 11.
As it is shown on figure 3, guide 33 is specially guide post, guide block 34 is placed on this guide post and can slide along this guide post.Certainly, guide 33 can be also the guide rail mated with guide block 34, makes guide block 34 move along predetermined track, equally also can realize guide effect.
The chemiluminescence immunoassay system of employing said structure, compact conformation, lightly, it is easy to carry, and utilize the optimal design-aside of sample arm device 30 and sample reagent tray 10, reduce volume, reduce manufacturing cost, for chemiluminescence immunoassay system use, mobile provide convenient.
In a particular embodiment, guide block 34 drives to move back and forth along guide 33 by motor, and in order to effectively guarantee the accuracy of chemiluminescence immunoassay system, power source 35 adopts motor, to guarantee the accuracy of displacement.
As it is shown on figure 3, step motor drive Timing Belt moves back and forth between driving wheel and driven pulley, and guide block 34 is fixedly connected on Timing Belt such that it is able to radially move under the drive of Timing Belt, and simple and convenient realizes moving radially of sample needle 31.
Meanwhile, for the moving displacement of accurate sample needle 31, and calculating initial position for it, this sample arm device 30 is additionally provided with optocoupler and optocoupler catch, so that it is guaranteed that the accuracy moved radially.
Sample needle 31 is installed on guide block 34 by separator tube 36, when sample needle 31 move downward touch vessel time, separator tube 36 can provide certain cushion effect for it, it is to avoid sample needle 31 sustains damage.Concrete, this separator tube 36 can include outer tube and connect the elastic component of sample needle 31.Certainly, separator tube 36 can be also other form, only needs to provide buffering for sample needle 31, it is to avoid it sustains damage.
For above-described embodiment, circumference drive division and vertical drive division are done and further optimize design by this sample arm device 30, and specifically, this sample arm device 30 is provided with ball spline shaft 37 and is placed on the hub splines 38 of this ball spline shaft 37.The rotation of hub splines 38 circumference restriction ball spline shaft 37, meanwhile, the ball spline shaft 37 that can lead does the movement of axial direction along the key of hub splines 38, thus realizing the vertical mobile of ball spline shaft 37.
In conjunction with Fig. 3, circumference drive motor 39-1 holder pivots by the relative sample arm device 30 of belt drives hub splines 38, and vertically drive motor 39-2 drives ball spline shaft 37 vertically to move.So, by simple in construction, compact structure, effectively achieve sample arm 32 and drive circumferentially rotating and vertically moving of sample needle 31.
Above a kind of chemiluminescence immunoassay system provided by the present invention and sample reagent tray thereof are described in detail.Principles of the invention and embodiment are set forth by specific case used herein, and the explanation of above example is only intended to help to understand method and the core concept thereof of the present invention.It should be pointed out that, for those skilled in the art, under the premise without departing from the principles of the invention, it is also possible to the present invention carries out some improvement and modification, these improve and modify in the protection domain also falling into the claims in the present invention.
Claims (13)
1. the sample reagent tray of a chemiluminescence immunoassay system, it is characterized in that, the disk body (11) of described sample reagent tray (10) is provided with outer ring mounting groove (12) and inner ring mounting groove (13), to hold sample cell (40) and Reagent Tube (50) respectively.
2. sample reagent tray according to claim 1, it is characterised in that described outer ring mounting groove (12) and described inner ring mounting groove (13) are all arranged concentrically with described disk body (11).
3. sample reagent tray according to claim 2, it is characterized in that, described outer ring mounting groove (12) includes multiple arcuate groove and the arc-shaped seat (121) of the notch outer rim being stuck in described arcuate groove, and described arc-shaped seat (121) offers the circular hole (1211) of multiple coupling sample cell (40)；Described inner ring mounting groove (13) arranges multiple and described Reagent Tube (50) placed hole one to one.
4. sample reagent tray according to claim 3, it is characterised in that described disk body (11) is hollow-core construction.
5. the sample reagent tray according to any one of claim 1-4, it is characterized in that, described sample reagent tray (10) is provided with the installing hole (14) of the sample arm device (30) of fixing described chemiluminescence immunoassay system.
6. the sample reagent tray according to any one of claim 1-4, it is characterized in that, the periphery of described disk body (11) is provided with arc notch, and the arc perisporium of the reaction tray (20) of described chemiluminescence immunoassay system inserts described arc notch.
7. sample reagent tray according to claim 1, it is characterized in that, the bottom of described disk body (11) is provided with fixed supporting leg (15), and described fixed supporting leg (15) is fixedly supported to the main frame of described chemiluminescence immunoassay system.
8. sample reagent tray according to claim 1, it is characterised in that the bottom of described disk body (11) is provided with refrigerating plant (16), with to the reagent refrigerating thermal-insulation in described Reagent Tube (50).
9. a chemiluminescence immunoassay system, disk body (11) including sample arm device (30) and storing samples, reagent, described sample arm device (30) includes the vertical drive division driving the circumferential drive division of sample needle (31) circumference movement of described sample arm device (30) and vertically movement, it is characterized in that, also including the radial drive portion driving the sample needle (31) of described sample arm device (30) to move radially, described disk body (11) adopts the sample reagent tray (10) according to any one of claim 1 to 8；Described sample arm device (30) is placed in the middle part of described sample reagent tray (10).
10. chemiluminescence immunoassay system according to claim 9, it is characterised in that described radial drive portion includes,
Guide (33), the direction of stretching out along the sample arm (32) of described sample arm device (30) is arranged；
Guide block (34), be connected described sample arm device (30) sample needle (31), described guide (33) lead described guide block (34) slide；With
Power source (35), drives described guide block (34) to move back and forth along described guide (33).
11. chemiluminescence immunoassay system according to claim 10, it is characterised in that described guide (33) is the guide rail or guide post that mate with described guide block (34).
12. chemiluminescence immunoassay system according to claim 10, it is characterized in that, described sample arm (32) is provided with the separator tube (36) being fixed on described guide block (34), and described sample needle (31) is installed on described separator tube (36).
13. chemiluminescence immunoassay system according to claim 9, it is characterized in that, described sample arm device (30) is provided with ball spline shaft (37) and is placed on the hub splines (38) of described ball spline shaft (37), the sample arm (32) of described sample arm device (30) is fixed on the top of described ball spline shaft (37), the circumferential drive motor (39-1) of described circumference drive division drives described hub splines (38) to drive described ball spline shaft (37) to rotate, the vertical drive motor (39-2) of described vertical drive division drives described ball spline shaft (37) vertically to move relative to described hub splines (38).
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Cited By (6)
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| CN106742748A (en) * | 2016-12-30 | 2017-05-31 | 华测检测认证集团股份有限公司 | Detecting Pesticide sets ready sample holding structure |
| CN106929390A (en) * | 2017-04-01 | 2017-07-07 | 刘银安 | A kind of mounting disc and automatic pass lid mechanism |
| CN111856055A (en) * | 2020-07-27 | 2020-10-30 | 长沙开元仪器有限公司 | Feeding mechanism |
| CN112014571A (en) * | 2020-08-20 | 2020-12-01 | 金华科生物技术河北有限公司 | Semi-quantitative detection device for C-reactive protein colloidal gold method |
| CN114236129A (en) * | 2021-12-20 | 2022-03-25 | 江苏集萃纳米应用技术研究所有限公司 | In-vitro immunodiagnosis reagent background luminescence processing system |
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Application publication date: 20160727 |