CN105796966A - 防治慢性疲劳综合症的中药组合物及其制备方法和应用 - Google Patents
防治慢性疲劳综合症的中药组合物及其制备方法和应用 Download PDFInfo
- Publication number
- CN105796966A CN105796966A CN201610235177.9A CN201610235177A CN105796966A CN 105796966 A CN105796966 A CN 105796966A CN 201610235177 A CN201610235177 A CN 201610235177A CN 105796966 A CN105796966 A CN 105796966A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- medicine composition
- chronic fatigue
- fatigue syndrome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 90
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 title claims abstract description 71
- 239000000203 mixture Substances 0.000 title claims abstract description 59
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims abstract description 68
- 239000002994 raw material Substances 0.000 claims abstract description 31
- 210000000582 semen Anatomy 0.000 claims abstract description 24
- 241000628997 Flos Species 0.000 claims description 26
- 239000008187 granular material Substances 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 239000000284 extract Substances 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 10
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 7
- 239000012141 concentrate Substances 0.000 claims description 4
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 3
- 235000013402 health food Nutrition 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 2
- 238000005259 measurement Methods 0.000 claims description 2
- 235000014676 Phragmites communis Nutrition 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 abstract description 14
- 206010068319 Oropharyngeal pain Diseases 0.000 abstract description 8
- 208000011580 syndromic disease Diseases 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 5
- 210000003205 muscle Anatomy 0.000 abstract description 5
- 206010016256 fatigue Diseases 0.000 abstract description 4
- 230000007774 longterm Effects 0.000 abstract description 4
- 208000019116 sleep disease Diseases 0.000 abstract description 4
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 244000291564 Allium cepa Species 0.000 abstract 1
- 235000002732 Allium cepa var. cepa Nutrition 0.000 abstract 1
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 235000007516 Chrysanthemum Nutrition 0.000 abstract 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 abstract 1
- 206010024642 Listless Diseases 0.000 abstract 1
- 235000006679 Mentha X verticillata Nutrition 0.000 abstract 1
- 235000002899 Mentha suaveolens Nutrition 0.000 abstract 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 abstract 1
- 235000004347 Perilla Nutrition 0.000 abstract 1
- 244000124853 Perilla frutescens Species 0.000 abstract 1
- 235000008216 herbs Nutrition 0.000 abstract 1
- 208000017971 listlessness Diseases 0.000 abstract 1
- 230000006996 mental state Effects 0.000 abstract 1
- 235000021018 plums Nutrition 0.000 abstract 1
- 201000007100 Pharyngitis Diseases 0.000 description 11
- 238000000605 extraction Methods 0.000 description 9
- 206010047700 Vomiting Diseases 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 230000008673 vomiting Effects 0.000 description 8
- 235000009508 confectionery Nutrition 0.000 description 7
- 206010011224 Cough Diseases 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 6
- 241000700159 Rattus Species 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 238000005303 weighing Methods 0.000 description 6
- 206010019233 Headaches Diseases 0.000 description 5
- 230000007812 deficiency Effects 0.000 description 5
- 231100000869 headache Toxicity 0.000 description 5
- 210000004072 lung Anatomy 0.000 description 5
- 239000007921 spray Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 208000016150 acute pharyngitis Diseases 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 3
- 208000006820 Arthralgia Diseases 0.000 description 3
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 102000003777 Interleukin-1 beta Human genes 0.000 description 3
- 108090000193 Interleukin-1 beta Proteins 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 230000003340 mental effect Effects 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 208000020685 sleep-wake disease Diseases 0.000 description 3
- 230000035922 thirst Effects 0.000 description 3
- 208000023409 throat pain Diseases 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- 208000000112 Myalgia Diseases 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 206010003549 asthenia Diseases 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 208000013116 chronic cough Diseases 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 238000011552 rat model Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 241000244186 Ascaris Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 241000371997 Eriocheir sinensis Species 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 239000001116 FEMA 4028 Substances 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 208000019914 Mental Fatigue Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010040007 Sense of oppression Diseases 0.000 description 1
- 206010040849 Skin fissures Diseases 0.000 description 1
- 239000004376 Sucralose Substances 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 206010043458 Thirst Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010051373 Wound haemorrhage Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 201000009361 ascariasis Diseases 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 description 1
- 229960004853 betadex Drugs 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000006189 buccal tablet Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 210000003191 femoral vein Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 208000030208 low-grade fever Diseases 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及一种防治慢性疲劳综合症的中药组合物及其制备方法和应用。所述中药组合物的活性成分由以下重量份的原料制备而成:金银花10‑20份,紫苏叶5‑15份,韭菜子5‑15份,白及5‑15份,薄荷5‑15份,广藿香5‑15份,菊花5‑15份,芦根10‑20份,胖大海2‑11份,黄精10‑20份,乌梅5‑15份。该中药组合物能够有效防治慢性疲劳综合症,可以显著改善慢性疲劳综合症患者的各种症状,患者的精神状态、身体舒适感、咽喉痛、肌肉或关节酸痛、神疲乏力、睡眠障碍等症状都能得到明显改善。且该中药组合物采用纯中药为原料,安全稳定、无毒副作用,适合患者长期服用。
Description
技术领域
本发明涉及保健品及中药领域,特别是涉及一种防治慢性疲劳综合症的中药组合物及其制备方法和应用。
背景技术
慢性疲劳综合症(简称CFS)。CFS是1994年由美国疾病控制中心正式命名的,也叫作“亚健康状态”、“灰色状态”、“第三状态”。慢性疲劳综合症是一种在健康人群中发生的、以体力和脑力疲劳为特征的综合症,常常伴随着睡眠紊乱、身体乏力、低热、咽炎、头痛、肌肉痛和抑郁等症状。在当代工作快节奏、高压力和多变的环境中,人们的生活与工作也进入了快节奏轨道。长期处于高压状态的人,就像一根因长期紧绷而失去弹性的橡皮筋,最终导致慢性疲劳综合症的发生。据美国流行病学调查发现,人群中14%的成人男性,29%的女性表现有明显疲劳的症状。美国疾病控制中心预测,慢性疲劳综合症将成为21世纪影响人类健康的一个主要问题。近年来,我国慢性疲劳综合症患者正在不断增长,由此引发的“过劳”致死的人数也在不断上升,成为威胁人类健康的“新杀手”。
目前还没有一种令人满意的、能有效治疗CFS的方法,对于CFS的治疗只是侧重减轻或改善症状。
发明内容
基于此,本发明的目的之一在于提供一种防治慢性疲劳综合症的中药组合物。
实现上述发明目的具体技术方案如下:
一种防治慢性疲劳综合症的中药组合物,其活性成分由以下重量份的原料制备而成:金银花10-20份,紫苏叶5-15份,韭菜子5-15份,白及5-15份,薄荷5-15份,广藿香5-15份,菊花5-15份,芦根10-20份,胖大海2-11份,黄精10-20份,乌梅5-15份。
在其中一些实施例中,所述防治慢性疲劳综合症的中药组合物的活性成分由以下重量份的原料制备而成:金银花13-17份,紫苏叶7-12份,韭菜子7-12份,白及7-12份,薄荷7-12份,广藿香7-12份,菊花7-12份,芦根13-17份,胖大海4-8份,黄精13-17份,乌梅7-12份。
在其中一些实施例中,所述防治慢性疲劳综合症的中药组合物的活性成分由以下重量份的原料制备而成:金银花15份,紫苏叶10份,韭菜子10份,白及10份,薄荷10份,广藿香10份,菊花10份,芦根15份,胖大海6份,黄精15份,乌梅10份。
上述防治慢性疲劳综合症的中药组合物中所用药材原料的药理如下:
金银花:甘,寒。清热解毒,疏散风热。用于痈肿疔疮,喉痹,丹毒,热毒血痢,风热感冒,温病发热。
紫苏叶:辛,温。解表散寒,行气和胃。用于风寒感冒,咳嗽呕恶,妊娠呕吐,鱼蟹中毒。
韭菜子:辛、甘,温。温补肝肾,壮阳固精。用于肝肾亏虚,腰膝酸痛,阳痿遗精,遗尿、尿频,白浊带下。
黄精:性平,味甘。补气养阴,健脾,润肺,益肾。用于脾胃气虚,体倦乏力,胃阴不足,口干食少,肺虚燥咳,劳嗽咳血,精血不足,腰膝酸软,须发早白,内热消渴。
白及:苦、甘、涩,微寒。收敛止血,消肿生肌。用于咯血,吐血,外伤出血,疮疡肿毒,皮肤皲裂。
薄荷:辛,凉。疏散风热,清利头目,利咽,透疹,疏肝行气。用于风热感冒,风温初起,头痛,目赤,喉痹,口疮,风疹,麻疹,胸胁胀闷。
广藿香:辛,微温。芳香化浊,和中止呕,发表解暑。用于湿浊中阻,脘痞呕吐,暑湿表证,湿温初起,发热倦怠,胸闷不舒,寒湿闭暑,腹痛吐泻,鼻渊头痛。
菊花:甘、苦,微寒。散风清热,平肝明目,清热解毒。用于风热感冒,头痛眩晕,目赤肿痛,眼目昏花,疮痈肿毒。
芦根:甘,寒。清热泻火,生津止渴,除烦,止呕,利尿。用于热病烦渴,肺热咳嗽,肺痈吐脓,胃热呕哕,热淋涩痛。
胖大海:甘,寒。清热润肺,利咽开音,润肠通便。用于肺热声哑,干咳无痰,咽喉干痛,热结便闭,头痛目赤。
乌梅:酸、涩,平。敛肺,涩肠,生津,安蛔。用于肺虚久咳,久泻久痢,虚热消渴,蛔厥、呕吐腹痛。
本发明的另一目的在于提供上述防治慢性疲劳综合症的中药组合物的制备方法。
具体技术方案如下:
一种上述防治慢性疲劳综合症的中药组合物的制备方法,包括以下步骤:按配比称取上述中药组合物的制备原料,混合后用水或乙醇水溶液进行提取,将提取液过滤,所得滤液浓缩,浓缩液干燥得干膏,即为所述防治慢性疲劳综合症的中药组合物。
在其中一些实施例中,所述水或乙醇水溶液的用量为所述原料重量的7-11倍,所述浓缩为将滤液浓缩至相对密度为1.05-1.25的浓缩液,相对密度的测量温度为55℃-65℃。
本发明的另一目的在于提供上述中药组合物的应用。
具体技术方案如下:
上述中药组合物在制备防治慢性疲劳综合症的药物或保健食品中的应用。
在其中一些实施例中,所述药物的剂型为颗粒剂、片剂。
本发明的防治慢性疲劳综合症的中药组合物及其制备方法和应用具有以下有益效果:
发明人通过长期的经验积累和大量实验研究从众多中药材中精选上述11种原料,同时研究其最佳配比,最终制备成本发明的防治慢性疲劳综合症的中药组合物,该中药组合物能够有效防治慢性疲劳综合症,可以显著改善慢性疲劳综合症患者的各种症状。以该中药组合物制备而成的中药颗粒剂经过药效实验以及临床实验证明能够显著改善慢性疲劳综合症的各种症状,可以改善慢性疲劳综合症患者的精神状态以及身体舒适感,患者的咽喉痛、神疲乏力、肌肉或关节酸痛、睡眠障碍等症状都能得到明显改善。且该中药组合物采用纯中药为原料,安全稳定、无毒副作用,适合患者长期服用,亦可辅以药品、保健食品上可接受的辅料制备成各种剂型的药品、保健品加以推广应用。
本发明的防治慢性疲劳综合症的中药组合物的制备方法工艺简单,易于操作。
具体实施方式
以下结合具体实施例对本发明做进一步的阐述。
本发明的防治慢性疲劳综合症的中药组合物的制备方法为:称取中药材,充分混合或粉碎后加入适量的水或不同质量分数的乙醇水溶液按照行业内常规提取方法进行提取,得到的滤液经浓缩,干燥后得干膏,即为所述中药组合物,将干膏制粒后得到防治慢性疲劳综合症的中药颗粒剂。
实施例1防治慢性疲劳综合症的中药组合物
本实施例的防治慢性疲劳综合症的中药组合物由以下重量份的原料制备而成:金银花20份,紫苏叶15份,韭菜子15份,白及15份,薄荷15份,广藿香15份,菊花15份,芦根20份,胖大海11份,黄精20份,乌梅15份。
上述防治慢性疲劳综合症的中药组合物的制备方法如下:
称取上述重量份的原料,充分混合,置于提取罐中,加入质量为上述原料总重量的10倍的水煎煮提取2次,收集提取液,提取液滤过,滤液浓缩至相对密度为1.05-1.25(测量温度55℃-65℃)的浓缩液,干燥得干膏,即得所述防治慢性疲劳综合症的中药组合物。
实施例2防治慢性疲劳综合症的中药组合物
本实施例的防治慢性疲劳综合症的中药组合物由以下重量份的原料制备而成:金银花15份,紫苏叶10份,韭菜子10份,白及10份,薄荷10份,广藿香10份,菊花10份,芦根15份,胖大海6份,黄精15份,乌梅10份。
上述防治慢性疲劳综合症的中药组合物的制备方法如下:
称取上述重量份的原料,充分混合,置于提取罐中,加入质量为上述原料总重量的10倍的水煎煮提取2次,收集提取液,提取液滤过,滤液浓缩至相对密度为1.05-1.25(测量温度55℃-65℃)的浓缩液,干燥得干膏,即得所述防治慢性疲劳综合症的中药组合物。
实施例3防治慢性疲劳综合症的中药组合物
本实施例的防治慢性疲劳综合症的中药组合物由以下重量份的原料制备而成:金银花10份,紫苏叶5份,韭菜子5份,白及5份,薄荷5份,广藿香5份,菊花5份,芦根10份,胖大海2份,黄精10份,乌梅5份。
上述防治慢性疲劳综合症的中药组合物的制备方法如下:
称取上述重量份的原料,充分混合,置于提取罐中,加入质量为上述原料总重量的10倍的水煎煮提取2次,收集提取液,提取液滤过,滤液浓缩至相对密度为1.05-1.25(测量温度55℃-65℃)的浓缩液,干燥得干膏,即得所述防治慢性疲劳综合症的中药组合物。
实施例4防治慢性疲劳综合症的中药组合物
本实施例的防治慢性疲劳综合症的中药组合物由以下重量份的原料制备而成:金银花15份,紫苏叶10份,韭菜子10份,白及10份,薄荷10份,广藿香10份,菊花10份,芦根15份,胖大海6份,黄精15份,乌梅10份。
上述防治慢性疲劳综合症的中药组合物的制备方法如下:
称取上述重量份的原料,充分混合,置于提取罐中,加入质量为上述原料总重量的8倍、质量分数为30%的乙醇水溶液提取2次,收集提取液,提取液滤过,滤液浓缩至相对密度为1.05-1.25(测量温度55℃-65℃)的浓缩液,干燥得干膏,即得所述防治慢性疲劳综合症的中药组合物。
实施例5防治慢性疲劳综合症的中药组合物
本实施例的防治慢性疲劳综合症的中药组合物由以下重量份的原料制备而成:金银花15份,紫苏叶10份,韭菜子10份,白及10份,薄荷10份,广藿香10份,菊花10份,芦根15份,胖大海6份,黄精15份,乌梅10份。
上述防治慢性疲劳综合症的中药组合物的制备方法如下:
称取上述重量份的原料,充分混合,粉粹,加入质量为上述原料总重量的8倍的水置于超声提取器中,超声提取两次(分别为1小时,半小时),提取液滤过,滤液浓缩至相对密度为1.05-1.25(测量温度55℃-65℃)的浓缩液,干燥得干膏,即得所述防治慢性疲劳综合症的中药组合物。
实施例6防治慢性疲劳综合症的中药组合物
本实施例的防治慢性疲劳综合症的中药组合物由以下重量份的原料制备而成:金银花15份,紫苏叶10份,韭菜子10份,白及10份,薄荷10份,广藿香10份,菊花10份,芦根15份,胖大海6份,黄精15份,乌梅10份。
上述防治慢性疲劳综合症的中药组合物的制备方法如下:
称取上述重量份的原料,充分混合,粉粹,加入质量为上述原料总重量的8倍、质量分数为25%的乙醇水溶液置于超声提取器中,超声提取两次(分别为1小时,半小时),提取液滤过,滤液浓缩至相对密度为1.05-1.25(测量温度55℃-65℃)的浓缩液,干燥得干膏,即得所述防治慢性疲劳综合症的中药组合物。
实施例7防治慢性疲劳综合症的中药颗粒剂
将实施例2中制备的防治慢性疲劳综合症的中药中组合物粉碎,取粉碎的中药组合物36份、三氯蔗糖26份、糊精15份、倍他环糊精23份,混合后按常规方法制粒即得。
实施例8防治慢性疲劳综合症的中药颗粒剂的药效实验
咽喉肿痛是慢性疲劳综合症患者最常见、最普遍的症状之一。本实施例对本发明的防治慢性疲劳综合症的中药颗粒剂进行了抗咽炎的药效实验研究。
(1)分组及建立急性咽炎大鼠模型:48只大鼠随机分成6组,每组8只:正常组、模型组、对照组(对照组药物为:金嗓子喉宝)、低剂量实验组(0.36g/kg)、中剂量实验组(0.54g/kg)、高剂量实验组(0.72g/kg),实验组药物为实施例7制备的防治疲劳综合症的颗粒剂。除正常组外,其它5组大鼠用浓氨水进行喉头喷雾处理诱发急性咽炎,建立急性咽炎大鼠模型。
(2)药物治疗:连续7天用喉头喷雾器给正常组与模型组大鼠咽部喷蒸馏水、给对照组大鼠咽部喷金嗓子喉宝(2g/kg)、给实验组大鼠咽部分别喷低(0.36g/kg)、中(0.54g/kg)、高(0.72g/kg)剂量的实验组药物;实验组与对照组药物均用蒸馏水溶解后再用药;所喷蒸馏水与药液的用量均为5mL。7天后股静脉取血,3000rpm/min离心15min,取血清检测IL-1β和TNF-α含量。
(3)实验结果:数据统计分析结果如表一所示:
表一 大鼠血清中IL-1β及TNF-α的含量
实验结果表明,与模型组比较,本发明的防治慢性疲劳综合症的中药颗粒剂以高剂量(0.72g/kg)和中剂量(0.54g/kg)用药时均能显著降低急性咽炎大鼠血清中IL-1β及TNF-α的含量,且高剂量组与金嗓子喉宝的治疗效果相当,因此本发明的防治慢性疲劳综合症的中药颗粒剂具有一定抗咽炎作用。
实施例9防治慢性疲劳综合症的中药颗粒剂的临床实验
对实施例7的防治慢性疲劳综合症的中药颗粒剂进行临床疗效试验。
1、受试者入选标准:
(1)男女不限,配合产品试用要求;(2)具有明显的慢性疲劳综合症症状(咽喉痛、神疲乏力,肌肉关节痛、睡眠障碍等);(3)能很好的配合试验,在试用期间能保持良好生活作息时间和饮食习惯。
2、受试药物、药物使用方法和时间
实验组:
受试药物为实施例7的防治慢性疲劳综合症的颗粒剂,规格为每袋12g;
药物的使用时间:使用时间为7天,每日3袋;使用方法:开水冲服。
对照组:
对照药物为西洋参含片,每次一片,每日三次,使用时间为7天。
3、试用结果分析
本次试用人数共50人(随机分成两组,对照组与实验组分别为25人),共收回试用反馈表50份。统计结果如表二、表三所示。
表二:药物试用后的整体感觉
选项 | 实验组(25人) | 对照组(25人) |
1、更有精神,身体没有明显不适 | 9 | 5 |
2、精神较前改善,身体略有不适感 | 5 | 6 |
3、精神稍改善,但其他症状无明显改善 | 5 | 6 |
4、精神状态如前,但其他症状有所改善 | 5 | 4 |
5、毫无变化 | 1 | 4 |
有效率 | 96% | 84% |
表三:实验组与对照组主要症状的改变情况
从表二、表三的结果可知,本发明的防治慢性疲劳综合症的中药颗粒剂可以显著改善慢性疲劳综合症患者的各种症状,试用人员的精神状态以及身体整体舒适感都得到改善,咽喉痛、肌肉或关节酸痛、神疲乏力、睡眠障碍等症状都得到明显改善,因此,本发明的慢性疲劳综合症的中药颗粒剂可以有效防治慢性疲劳综合症。
以上所述实施例的各技术特征可以进行任意的组合,为使描述简洁,未对上述实施例中的各个技术特征所有可能的组合都进行描述,然而,只要这些技术特征的组合不存在矛盾,都应当认为是本说明书记载的范围。
以上所述实施例仅表达了本发明的几种实施方式,其描述较为具体和详细,但并不能因此而理解为对发明专利范围的限制。应当指出的是,对于本领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干变形和改进,这些都属于本发明的保护范围。因此,本发明专利的保护范围应以所附权利要求为准。
Claims (7)
1.一种防治慢性疲劳综合症的中药组合物,其特征在于,其活性成分由以下重量份的原料制备而成:金银花10-20份,紫苏叶5-15份,韭菜子5-15份,白及5-15份,薄荷5-15份,广藿香5-15份,菊花5-15份,芦根10-20份,胖大海2-11份,黄精10-20份,乌梅5-15份。
2.根据权利要求1所述的防治慢性疲劳综合症的中药组合物,其特征在于,其活性成分由以下重量份的原料制备而成:金银花13-17份,紫苏叶7-12份,韭菜子7-12份,白及7-12份,薄荷7-12份,广藿香7-12份,菊花7-12份,芦根13-17份,胖大海4-8份,黄精13-17份,乌梅7-12份。
3.根据权利要求2所述的防治慢性疲劳综合症的中药组合物,其特征在于,其活性成分由以下重量份的原料制备而成:金银花15份,紫苏叶10份,韭菜子10份,白及10份,薄荷10份,广藿香10份,菊花10份,芦根15份,胖大海6份,黄精15份,乌梅10份。
4.一种权利要求1-3任一项所述的防治慢性疲劳综合症的中药组合物的制备方法,其特征在于,包括以下步骤:按配比称取权利要求1-3任一项所述的原料,混合后用水或乙醇水溶液进行提取,将提取液过滤,所得滤液浓缩,浓缩液干燥得干膏,即为所述防治慢性疲劳综合症的中药组合物。
5.根据权利要求4所述的防治慢性疲劳综合症的中药组合物的制备方法,其特征在于,所述水或乙醇水溶液的用量为所述原料重量的7-11倍,所述浓缩为将滤液浓缩至相对密度为1.05-1.25的浓缩液,相对密度的测量温度为55℃-65℃。
6.权利要求1-3任一项所述的中药组合物在制备防治慢性疲劳综合症的药物或保健食品中的应用。
7.根据权利要求6所述的应用,其特征在于,所述药物的剂型为颗粒剂或片剂。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610235177.9A CN105796966A (zh) | 2016-04-14 | 2016-04-14 | 防治慢性疲劳综合症的中药组合物及其制备方法和应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610235177.9A CN105796966A (zh) | 2016-04-14 | 2016-04-14 | 防治慢性疲劳综合症的中药组合物及其制备方法和应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105796966A true CN105796966A (zh) | 2016-07-27 |
Family
ID=56459274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610235177.9A Pending CN105796966A (zh) | 2016-04-14 | 2016-04-14 | 防治慢性疲劳综合症的中药组合物及其制备方法和应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105796966A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111298020A (zh) * | 2020-03-31 | 2020-06-19 | 刘敏如女科医系研究院(深圳)有限公司 | 具有抗疲劳功效的中药组合物及其制备方法与应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1666674A (zh) * | 2005-04-27 | 2005-09-14 | 邵建国 | 一种利咽护喉茶及其制备方法 |
CN102283298A (zh) * | 2011-09-15 | 2011-12-21 | 李雄骥 | 一种清火解暑茶 |
CN103610834A (zh) * | 2013-11-25 | 2014-03-05 | 湖南希尔天然药业有限公司 | 中药组合物及其制备方法和应用 |
CN103845642A (zh) * | 2014-01-24 | 2014-06-11 | 湖北威仕生物药业股份有限公司 | 一种清热解毒凉血美颜的组合物 |
-
2016
- 2016-04-14 CN CN201610235177.9A patent/CN105796966A/zh active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1666674A (zh) * | 2005-04-27 | 2005-09-14 | 邵建国 | 一种利咽护喉茶及其制备方法 |
CN102283298A (zh) * | 2011-09-15 | 2011-12-21 | 李雄骥 | 一种清火解暑茶 |
CN103610834A (zh) * | 2013-11-25 | 2014-03-05 | 湖南希尔天然药业有限公司 | 中药组合物及其制备方法和应用 |
CN103845642A (zh) * | 2014-01-24 | 2014-06-11 | 湖北威仕生物药业股份有限公司 | 一种清热解毒凉血美颜的组合物 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111298020A (zh) * | 2020-03-31 | 2020-06-19 | 刘敏如女科医系研究院(深圳)有限公司 | 具有抗疲劳功效的中药组合物及其制备方法与应用 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101422579B (zh) | 一种治疗口腔溃疡的中药制剂 | |
CN101954006B (zh) | 治疗失眠的中药 | |
CN103041256B (zh) | 一种治疗小儿反复呼吸道感染的中药制剂 | |
CN103041257B (zh) | 治疗小儿发热高烧呼吸道感染的中药制剂 | |
CN103041255B (zh) | 治疗小儿咽喉肿痛呼吸道感染的中药制剂 | |
CN105250460A (zh) | 一种治疗兔腹泻的药物组合物及其制备方法 | |
CN104800817A (zh) | 用于治疗狗鼻炎的药物组合物及其制备方法 | |
CN105796966A (zh) | 防治慢性疲劳综合症的中药组合物及其制备方法和应用 | |
CN106668646A (zh) | 一种治疗鸡产蛋量下降的中药物 | |
CN102552560B (zh) | 一种有效治疗手足口病的复方组合药物 | |
CN104623615A (zh) | 一种治疗哮喘的药物 | |
CN103110743B (zh) | 一种治疗或预防神经衰弱的中药组合物及其制备方法 | |
CN104042872B (zh) | 治疗小儿感冒的中药组合物及其制备方法 | |
CN103690771B (zh) | 用于治疗羔羊大肠杆菌病的药物及其制备方法 | |
CN103041258B (zh) | 治疗小儿呼吸道感染伴纳差不食的中药制剂 | |
CN102366591B (zh) | 一种治疗风湿类风湿性关节炎的中草药酒及其制备方法 | |
CN103285116B (zh) | 一种用于治疗幼儿感冒的中药制剂 | |
CN104784566A (zh) | 一种治疗儿童呼吸道感染的中药 | |
CN104740157A (zh) | 一种治疗小儿哮喘的中药组合物 | |
CN104815076A (zh) | 一种用于治疗口臭的中药 | |
CN104161844A (zh) | 治疗禽畜流感的中药处方 | |
CN104186870A (zh) | 一种清火保健茶 | |
CN103041259B (zh) | 治疗小儿痰多咳嗽呼吸道感染的中药制剂 | |
CN103977126A (zh) | 一种治疗儿童发烧的退烧糖丸及其制备方法 | |
CN113797307A (zh) | 一种慢性肠胃炎用中药制剂、制备方法及其服用方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160727 |
|
RJ01 | Rejection of invention patent application after publication |