CN105796915A - 一种治疗糖尿病的组合物及其制备方法 - Google Patents
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Abstract
本发明公开了一种治疗糖尿病的组合物及其制备方法，所述的治疗糖尿病的组合物包括下述原料：人参、黄连、天花粉、杜仲、黄芪、丹参、枸杞、沙苑子、白芍、知母、五味子、羊儿草、长春花草、石斛、葛根、桔梗、地骨。所述的治疗糖尿病的组合物的制备方法包括以下步骤：将各原料洗净、并晒干；将晒干后的各原料分别粉碎成粉末，再搅拌混合均匀，得混合粉末；将混合粉末用水煎煮得混合液，过滤混合液得药渣和药液；浓缩药液，得固体颗粒，干燥固体颗粒得治疗糖尿病的组合物。本发明的有益效果为：本发明所述的组合物的各原料混合在一起发挥协同作用，具有降血糖的作用，能将血液内的死糖分解转化成可以被人体吸收的活性糖，使血液纯净，血管通畅。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗糖尿病的组合物及其制备方法。
背景技术
糖尿病是一组由于胰岛素分泌缺陷或胰岛素作用障碍所致的以高血糖为特征的代谢性疾病。持续高血糖与长期代谢紊乱可导致全身组织器官，特别是眼、肾、心血管及神经系统的损害及其功能障碍和衰竭，严重者可引起失水、电解质紊乱和酸碱平衡失调等急性并发症酮症酸中毒和高渗昏迷。
目前，治疗糖尿病主要采用西药和胰岛素，但西药和胰岛素毒副作用大，疗效单一，治标不治本。糖尿病患者在运用胰岛素进行治疗时有可能出现低血糖现象，过敏现象等不良反应，此外长期使用胰岛素来进行治疗的糖尿病患者有可能出现胰岛素耐性。
中国专利CN101700354A公开了一种治疗糖尿病的中药，其包括下述成分，西洋参、知母、石膏、苦瓜、蚕茧、黄芪、山药、生地、玄参、北沙参、麦冬、玉竹、黄精、天花粉、鸡内金、黄连、山萸肉、枸杞子、女贞子、淫羊藿，
发明内容
本发明的目的是提供一种治疗糖尿病的组合物及其制备方法。
本发明的目的是通过以下技术方案来实现的：
一种治疗糖尿病的组合物，包括下述重量份的原料，人参8-12份、黄连4-6份、天花粉8-12份、杜仲10-12份、黄芪10-12份、丹参8-12份、枸杞2-4份、沙苑子10-12份、白芍8-12份、知母8-12份、五味子8-12份、羊儿草10-14份、长春花草4-6份、石斛10-12份、葛根6-8份、桔梗8-10份、地骨8-10份。
进一步地，所述的治疗糖尿病的组合物，包括下述重量份的原料：人参10份、黄连5份、天花粉10份、杜仲11份、黄芪11份、丹参10份、枸杞3份、沙苑子11份、白芍10份、知母10份、五味子10份、羊儿草12份、长春花草5份、石斛11份、葛根7份、桔梗9份、地骨9份。
上述所述的治疗糖尿病的组合物的制备方法，包括以下步骤：
(1)将各原料洗净、并干燥；将各原料洗净防止原料中的杂质对药性造成影响。
(2)将干燥后的各原料分别粉碎成粉末，再搅拌混合均匀，得混合粉末；
(3)将混合粉末用水煎煮得混合液，过滤所述混合液得药液；
(4)浓缩步骤(3)所得药液，得固体颗粒，干燥所述固体颗粒得治疗糖尿病的组合物。
进一步地，步骤(1)中将各原料晾晒至各原料中分别含有的水分的质量分数为3％-5％。
进一步地，步骤(2)中将各原料分别粉碎成细度为30-40目的颗粒。将各原料进行粉碎，这样在煎煮时有利于原料中的活性成分溶出。
进一步地，步骤(2)中所述搅拌的速度为60-70r/min，所述搅拌的时间为5-10min。
进一步地，所述煎煮的温度为90-100℃，所述煎煮的时间为2-3h，所用水的重量与混合粉末的重量比为5-10:1。煎煮时保证煎煮的时间为2-3h时，使原料中的活性成分充分溶出，而所用水的重量与混合粉末的重量比为5-10:1，这样保证原料完全浸没在水中。
进一步地，步骤(4)中所述的干燥为将固体颗粒在干燥温度为60-70℃的温度下干燥8-12h。
进一步地，所述的治疗糖尿病的组合物在制备用于治疗糖尿病的药物中的应用。
人参属于五加科人参属植物，具有大补元气、复脉固脱、补脾益肺、生津止渴和安神益智的功效。人参中的人参皂苷具有抗肿瘤的作用。
黄连，多年生草本植物，属毛莨科黄连属，具有清热燥湿、泻火解毒的功效，黄连对金黄色葡萄糖菌、溶血性链球菌、肺炎球菌、脑膜炎双球菌、痢疾杆菌、阿米巴原虫、阴道滴虫及锥虫都有抑制的作用。此外，黄连还具有降低血糖、降低血压、降低血脂，治疗冠心病、心律失常和血栓的功效。
天花粉为葫芦科植物栝楼的根，性甘、微苦，具有清热泻火、生津止渴、排脓消肿的功效，常用来治疗肺燥咳血、消渴，常用它与滋阴药配合使用来治疗糖尿病。
杜仲(学名EucommiaulmoidesOliver)，又名胶木，为杜仲科植物，具有清除体内垃圾、加强人体细胞物质代谢、防止肌肉骨骼老化、平衡人体血压、分解体内胆固醇、降低体内脂肪、恢复血管弹性，增强机体免疫力的功效。杜仲中含有黄酮类和绿原酸化合物，而绿原酸在平衡血糖调控中发挥着重要的作用，它承担着由糖原异生和糖原分解所产生的内源性葡萄糖的形成。此外绿原酸及其合成衍生物有助于降低非胰岛素依赖性糖尿病患者所表现出的较高的肝病排泄速度。研究表明，杜仲在降血糖的同时，对肝肾不仅没有损伤，还有显著的维护功能。
黄芪又称北芪，为豆科植物蒙古黄芪或膜荚黄芪的根。味甘、微温，具有补气固表、利尿脱毒、敛疮生肌的功效。黄芪还具有降低血糖的作用，黄芪可通过增加糖原合成酶活性、胰岛素受体底物活性，使骨骼肌细胞心肌组织葡萄糖转运蛋白水平增加，使糖原合成酶活性增加而发挥增加胰岛素敏感性，而达到降低血糖的作用。
丹参又名赤参、紫丹参，为唇形科植物丹参的干燥根和根茎，具有活血祛瘀、痛经止痛、清心除烦、凉血消痈的功效。此外丹参还具有降低血糖、防治糖尿病并发症、调节血脂、改变微循环的作用，经常服用可以预防和治疗糖尿病及糖尿病导致的酮症酸中毒及低血糖。
枸杞为茄科植物枸杞干燥成熟果实，有补肾益精、养肝明目等功能。枸杞子可提高机体的免疫功能，具有抗肿瘤活性、降血糖、降低血清胆固醇及抗衰老和保肝的作用。
沙苑子为豆科一年生草本植物扁茎黄芪成熟种子，性温、味甘，内含脂肪油、鞣质、维生素A类物质等，具有温补肝肾、固精、明目的功效，常用来治疗肾虚腰痛、遗精早泄、眩晕目昏等症状。
白芍为毛茛科芍药属植物，白芍中含有的芍药甙句有抗菌、解热、抗炎、增加冠状动脉流量、改善心肌营养血流、扩张血管、对抗急性心肌缺血、抑制血小板聚集、镇静、镇痛、解痉、抗溃疡、调节血糖的作用。
知母(拉丁学名:AnemarrhenaasphodeloidesBunge)也叫毛知母，多年生草本植物，味苦、性寒，具有清热泻火，生津润燥的功效，常用来治疗外感热病，高热烦渴，肺热燥咳，骨蒸潮热，内热消渴，肠燥便秘等症状。
五味子为木兰科植物五味子的干燥成熟果实，味甘、性温，具有益气生津、补肾养心、收敛固涩的功效，常用来治疗气虚津伤、体倦多汗、短气心悸、失眠健忘、肾气不固等症状。
石斛又名石斛兰，属石斛兰属、兰科，具有益胃生津，滋阴清热的功效。常用来治疗阴伤津亏，口干烦渴，食少干呕，病后虚热，目暗不明等症状。
葛根为豆科植物葛根干燥的根，属葛属、豆科，性凉、味甘，具有清热、降火、排毒的功效，葛根中的异黄酮类化合物葛根素对高血压、高血脂、高血糖和心脑血管疾病均有一定的疗效。
桔梗别名包袱花、铃铛花、僧帽花，是多年生草本植物，属桔梗属、桔梗科，具有开宣肺气、祛痰排脓的功效，常用来治疗外感咳嗽、咽喉肿痛、痢疾腹痛等症状。
地骨为茄种植物枸杞等的根皮，味微甘，具有凉血除珍、清肺降火、降血糖、降血脂的功效。
本发明的有益效果为：因糖尿病为慢性疾病，患者在阴虚的同时大多伴有气虚，所以益气是糖尿病患者进补的重要原则，此外中医又称糖尿病为消渴病，而本发明所述的治疗糖尿病的组合物中五味子和人参具有补气的功效；天花粉和知母具有消渴的功效；黄连、杜仲、黄芪、丹参、葛根和地骨具有降低血糖的功效；本发明所述的治疗糖尿病的组合物的各原料混合在一起发挥协同作用，具有降血糖的作用，能将血液内的死糖分解转化成可以被人体吸收的活性糖，使血液纯净、血管通畅，恢复人体的自身糖代功能，且能凉血降压、镇静安神，消失糖尿病的并发症状。
具体实施方式
实施例一
一种治疗糖尿病的组合物，包括下述重量配比的原料：人参8g、黄连4g、天花粉8g、杜仲10g、黄芪10g、丹参8g、枸杞2g、沙苑子10g、白芍8g、知母8g、五味子8g、羊儿草10g、长春花草4g、石斛10g、葛根6g、桔梗8g、地骨8g。
上述所述的治疗糖尿病的组合物的制备方法，包括以下步骤：
(1)将各原料洗净、将各原料晾晒至各原料中分别含有的水分的质量分数为3％；将各原料洗净防止原料中的杂质对药性造成影响。
(2)将各原料分别粉碎成细度为30目的颗粒，这样在煎煮时有利于原料中的活性成分溶出，再将粉碎后的各原料在搅拌速度为60r/min的条件下搅拌10min，使其混合搅拌均匀，得混合粉末；
(3)将混合粉末用水煎煮，所用水的重量与混合粉末的重量比为5:1；所述煎煮的温度为100℃，为保证原料中的活性成分充分溶出，所述煎煮的时间为2h，煎煮完毕得混合药液，过滤混合液得药液。
(4)浓缩步骤(3)所得药液，得固体颗粒，将固体颗粒在干燥温度为60℃的干燥箱中干燥12h得治疗糖尿病的组合物。
实施例一所述的治疗糖尿病的组合物为片剂。
实施例二
一种治疗糖尿病的组合物，包括下述重量配比的原料：人参10g、黄连5g、天花粉10g、杜仲11g、黄芪11g、丹参10g、枸杞3g、沙苑子11g、白芍10g、知母10g、五味子10g、羊儿草12g、长春花草5g、石斛11g、葛根7g、桔梗9g、地骨9g。
上述所述的治疗糖尿病的组合物的制备方法，包括以下步骤：
(1)将各原料洗净、将各原料晾晒至各原料中分别含有的水分的质量分数为4％；将各原料洗净防止原料中的杂质对药性造成影响。
(2)将各原料分别粉碎成细度为35目的颗粒，这样在煎煮时有利于原料中的活性成分溶出，再将粉碎后的各原料在搅拌速度为65r/min的条件下搅拌7min，使其混合搅拌均匀，得混合粉末；
(3)将混合粉末用水煎煮，所用水的重量与混合粉末的重量比为7:1；所述煎煮的温度为95℃，为保证原料中的活性成分充分溶出，所述煎煮的时间为2.5h，煎煮完毕得混合药液，过滤混合液得药液。
(4)浓缩步骤(3)所得药液，得固体颗粒，将固体颗粒在干燥温度为65℃的干燥箱中干燥10h得治疗糖尿病的组合物。
实施例二所述的治疗糖尿病的组合物为颗粒剂。
实施例三
一种治疗糖尿病的组合物，包括下述重量配比的原料：人参12g、黄连6g、天花粉12g、杜仲12g、黄芪12g、丹参12g、枸杞4g、沙苑子12g、白芍12g、知母12g、五味子12g、羊儿草14g、长春花草6g、石斛12g、葛根8g、桔梗10g、地骨10g。
上述所述的治疗糖尿病的组合物的制备方法，包括以下步骤：
(1)将各原料洗净、将各原料晾晒至各原料中分别含有的水分的质量分数为5％；将各原料洗净防止原料中的杂质对药性造成影响。
(2)将各原料分别粉碎成细度为40目的颗粒，这样在煎煮时有利于原料中的活性成分溶出，再将粉碎后的各原料在搅拌速度为70r/min的条件下搅拌5min，使其混合搅拌均匀，得混合粉末；
(3)将混合粉末用水煎煮，所用水的重量与混合粉末的重量比为10:1；所述煎煮的温度为90℃，为保证原料中的活性成分充分溶出，所述煎煮的时间为3h，煎煮完毕得混合药液，过滤混合液得药液。
(4)浓缩步骤(3)所得药液，得固体颗粒，将固体颗粒在干燥温度为70℃的干燥箱中干燥8h得治疗糖尿病的组合物。
实施例三所述的治疗糖尿病的组合物为胶囊剂。
上述实施例二所述的治疗糖尿病的组合物的片剂在治疗糖尿病上的具体实施案例：
选取临床糖尿病患者200例，使用本发明所述的治疗糖尿病的组合物的片剂对临床200例患者进行治疗，每天服用本发明所述的治疗糖尿病的组合物的片剂三次，早中晚各两片(每片约0.48-0.5g)，饭后服用，一月为一个疗程。在使用本发明所述的治疗糖尿病的组合物的片剂治疗期间，患者的饮食习惯及生活环境均与使用本发明所述的治疗糖尿病的组合物的片剂治疗之前相同。
实验结果：治愈94％、有效6％。
治愈：血糖、尿糖正常，糖尿病的并发症如视力下降、糖尿病足症状消失；
有效：血糖、尿糖基本恢复正常，糖尿病的并发症消失；
无效：病症基本无变化。
实施例二在治疗糖尿病方面的具体实施案例
包某，男，61岁，患有高血糖，一直服用瑞罗宁，吃药期间包某的血糖保持正常，但是停药后包某的血糖又会升高，反反复复不能治愈，且在吃药期间包某有低血糖反应，经人介绍服用本发明所述的治疗糖尿病的组合物，服用本发明所述的治疗糖尿病的组合物三个疗程后，包某的血糖从22点降到12点，继续服用本发明所述的治疗糖尿病的组合物两个疗程后，包某的血糖降到7点左右，包某又继续服用半个疗程，血糖保持正常，停药后半年没有复发。
黄某，男，75岁，患糖尿病20多年，一直服用降血糖的药但是吃了不见好转，采用过注射胰岛素的方法进行治疗，但是注射胰岛素后后出现视力模糊、手脚冰凉，失眠的症状。经人介绍服用本发明所述的治疗糖尿病的组合物，服用本发明所述的治疗糖尿病的组合物三个疗程后，黄某的血糖从16点多降到10点多，继续服用本发明所说的治疗糖尿病的组合物两个疗程后，黄某的血糖恢复正常，且糖尿病引起的并发症也随之消失。
陈某，女，64岁，患有糖尿病，并伴随有口干、脚烂的并发症，服用本发明所述的治疗糖尿病的组合物三个疗程后，陈某的血糖由19点降到10点，继续服用本发明所述的治疗糖尿病的组合物两个疗程后，陈某的血糖降到6点左右，且口干、脚烂的并发症也随之消失。
陈某，女，62岁，由糖尿病病发眼病，视力模糊看不清东西，并伴随有手麻，服用本发明所述的治疗糖尿病的组合物三个疗程后，陈某的视力恢复正常，手麻症状消失。
杨某，女，48岁，患有糖尿病，服用本发明所述的治疗糖尿病的组合物三个疗程后，杨某的血糖由18点多降到12点多，继续服用本发明所述的治疗糖尿病的组合物两个疗程后，杨某的血糖由12点多降到6点多，停药半年后，杨某的糖尿病没有复发。
本发明不局限于上述最佳实施方式，任何人在本发明的启示下都可得出其他各种形式的产品，但不论在其细节上作任何变化，凡是具有与本申请相同或相近似的技术方案，均落在本发明的保护范围之内。
Claims (9)
1.一种治疗糖尿病的组合物，其特征在于，包括下述重量份的原料：人参8-12份、黄连4-6份、天花粉8-12份、杜仲10-12份、黄芪10-12份、丹参8-12份、枸杞2-4份、沙苑子10-12份、白芍8-12份、知母8-12份、五味子8-12份、羊儿草10-14份、长春花草4-6份、石斛10-12份、葛根6-8份、桔梗8-10份、地骨8-10份。
2.根据权利要求1所述的治疗糖尿病的组合物，其特征在于，包括下述重量份的原料：人参10份、黄连5份、天花粉10份、杜仲11份、黄芪11份、丹参10份、枸杞3份、沙苑子11份、白芍10份、知母10份、五味子10份、羊儿草12份、长春花草5份、石斛11份、葛根7份、桔梗9份、地骨9份。
3.权利要求1-2之一所述的治疗糖尿病的组合物的制备方法，其特征在于，包括以下步骤：
(1)将各原料洗净并干燥；
(2)将干燥后的各原料分别粉碎成粉末，再搅拌混合均匀，得混合粉末；
(3)将混合粉末用水煎煮得混合液，过滤所述混合液得药液；
(4)浓缩步骤(3)所得药液，得固体颗粒，干燥所述固体颗粒得治疗糖尿病的组合物。
4.根据权利要求3所述的治疗糖尿病的组合物的制备方法，其特征在于，步骤(1)中将各原料晾晒至各原料中分别含有的水分的质量分数为3％-5％。
5.根据权利要求3所述的治疗糖尿病的组合物的制备方法，其特征在于，步骤(2)中将各原料分别粉碎成细度为30-40目的颗粒。
6.根据权利要求3所述的治疗糖尿病的组合物的制备方法，其特征在于，步骤(2)中所述搅拌的速度为60-70r/min，所述搅拌的时间为5-10min。
7.根据权利要求3所述的治疗糖尿病的组合物的制备方法，其特征在于，所述煎煮的温度为90-100℃，所述煎煮的时间为2-3h，所用水的重量与混合粉末的重量比为5-10:1。
8.根据权利要求3所述的治疗糖尿病的组合物的制备方法，其特征在于，步骤(4)中所述的干燥为将固体颗粒在60-70℃的温度下干燥8-12h。
9.权利要求1-2之一所述的组合物在制备用于治疗糖尿病的药物中的应用。
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