CN105796729A - Blood-nourishing and brain-clearing soft capsule and preparation method thereof - Google Patents

Blood-nourishing and brain-clearing soft capsule and preparation method thereof Download PDF

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CN105796729A
CN105796729A CN201610187554.6A CN201610187554A CN105796729A CN 105796729 A CN105796729 A CN 105796729A CN 201610187554 A CN201610187554 A CN 201610187554A CN 105796729 A CN105796729 A CN 105796729A
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parts
weight
blood
brain
nourishing
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CN105796729B (en
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邹积宏
刘红梅
姜岸
祁正华
邹芳华
范铁男
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Heilongjiang University
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Heilongjiang University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486—Millettia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/536—Prunella or Brunella (selfheal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention relates to a blood-nourishing and brain-clearing soft capsule.Blood-nourishing and brain-clearing pills are included in Chinese Pharmacopoeia.The blood-nourishing and brain-clearing soft capsule comprises a capsule shell, and content is contained in the capsule shell.The content is prepared from, by weight, 200-300 parts of angelica sinensis, 210-285 parts of the rhizome of chuanxiong, 170-225 parts of white paeony roots, 175-230 parts of prepared rehmannia roots, 455-540 parts of uncaria rhynchophylla, 460-535 parts of caulis spatholobi, 485-540 parts of selfheal, 475-525 parts of cassia seeds, 475-525 parts of nacre mother of pearl, 220-305 parts of rhizoma corydalis and 35-75 parts of asarum.The capsule shell is prepared from, by weight, 180-200 parts of gelatin and 210-220 parts of purified water.The blood-nourishing and brain-clearing soft capsule is used for nourishing blood and clearing brain.

Description

Blood-nourishing and brain-refreshing soft capsule and preparation method thereof
Technical field:
The present invention relates to a kind of blood-nourishing and brain-refreshing soft capsule formula and preparation method thereof.
Background technology:
Blood-nourishing and brain-refreshing ball and granule are the kinds that Chinese Pharmacopoeia 2015 editions (1281-1282 page) records, this kinds of traditional Chinese medicines prescription At China's tradition ancient prescription, " SIWU TANG " that the Song dynasty " formulary of peaceful benevolent dispensary " is recorded on the basis of main formula according to the traditional Chinese medical science Theory, dialectical treating both the principal and secondary aspects of a disease flavour enhancing improves and forms, full side by ten simply medical material form (Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, hook Rattan, Caulis Spatholobi, Spica Prunellae, Semen Cassiae, Concha Margaritifera, Rhizoma Corydalis, Herba Asari), wherein Radix Rehmanniae Preparata is enriched blood yin nourishing, life essence-filling, marrow-benefitting, and the Radix Paeoniae Alba is put down Liver pain relieving, nourishing blood for regulating menstruation, two health preserving with drugs blood suppressing the hyperactive liver are with the effect of the side of building monarch.Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving, and Caulis Spatholobi is invigorated blood circulation easypro Muscle, nourishing blood for regulating menstruation, Rhizoma Chuanxiong activating QI to alleviate the depression, but wind-dryness is wet, promoting blood circulation and stopping pain, neat auxiliary monarch's side nourshing blood and promoting blood circulation, altogether battalion's circulation of qi promoting relaxing muscles and tendons, dredging collateral The merit of pain relieving side's minister.Ramulus Uncariae Cum Uncis heat clearing away suppressing the hyperactive liver；Relieving spasm by subduing liver-wind, Concha Margaritifera suppressing the hyperactive liver and subsiding YANG, arresting convulsion are calmed the nerves, and in collaborative assistant benefit side, heat clearing away is put down Liver, the energy of tranquillizing and allaying excitement, Semen Cassiae liver heat removing and eyesight improving, loosening bowel to relieve constipation.Spica Prunellae relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping, sensible, warming the lung Drink, mends effect of liver heat removing and eyesight improving, expelling pathogenic wind and restoring the functions of orifices in face, the most altogether again with Rhizoma Corydalis promoting blood circulation to remove blood stasis；Regulating QI to relieve pain, Herba Asari blood-activating and qi-promoting, dispel Wind pain relieving.The all medicines in full side are worked in coordination with, treating both the principal and secondary aspects of a disease, nourshing blood and promoting blood circulation, suppressing the hyperactive liver and subsiding YANG, dispelling wind and removing obstruction in the collateral.Can treat caused by blood deficiency and excessive liver-YANG Headache, staggers, susceptible to lose temper due to restlessness, the many diseases of insomnia and dreamful sleep.Further investigate through pharmacology, have and improve brain microcirculation, alleviation Vasospasm, blood pressure lowering, antithrombotic, antioxidation and improve carbohydrate metabolism, and pain relieving all has definite effect, has become treatment Dizziness, headache, incomplete brain blood supply, hypertension dizzy, the clinic of insomnia is widely used special effect Chinese.
Summary of the invention:
It is an object of the present invention to provide formula of a kind of blood-nourishing and brain-refreshing soft capsule and preparation method thereof.
Above-mentioned purpose is achieved through the following technical solutions:
A kind of blood-nourishing and brain-refreshing soft capsule, its composition includes: capsule shells, has content, described content in described capsule shells Thing include parts by weight be the Radix Angelicae Sinensis of 200-300, parts by weight be the Rhizoma Chuanxiong of 210-285, parts by weight be the white of 170-225 Chinese herbaceous peony, parts by weight be the Radix Rehmanniae Preparata of 175-230, parts by weight be the Ramulus Uncariae Cum Uncis of 455-540, parts by weight be the Sanguis Gallus domesticus of 460-535 Rattan, parts by weight be the Spica Prunellae of 485-540, parts by weight be the Semen Cassiae of 475-525, parts by weight be the treasure of 475-525 Pearl oyster, parts by weight be the Rhizoma Corydalis of 220-305, parts by weight be the Herba Asari of 35-75, described capsule shells includes parts by weight Gelatin, parts by weight for 180-200 are the pure water of 210-220.
Described blood-nourishing and brain-refreshing soft capsule, described content includes that Radix Angelicae Sinensis that parts by weight are 200, parts by weight are Radix Rehmanniae Preparata that the Radix Paeoniae Alba that the Rhizoma Chuanxiong of 210, parts by weight are 170, parts by weight are 175, parts by weight are Ramulus Uncariae Cum Uncis, the weight of 455 Spica Prunellae that Caulis Spatholobi that number is 460, parts by weight are 485, parts by weight be 475 Semen Cassiae, parts by weight be 475 Concha Margaritifera, parts by weight be 220 Rhizoma Corydalis, parts by weight be the Herba Asari of 35, described capsule shells includes that parts by weight are 180 Gelatin, parts by weight be the pure water of 210.
Described blood-nourishing and brain-refreshing soft capsule, described content includes that Radix Angelicae Sinensis that parts by weight are 300, parts by weight are Radix Rehmanniae Preparata that the Radix Paeoniae Alba that the Rhizoma Chuanxiong of 285, parts by weight are 225, parts by weight are 230, parts by weight are Ramulus Uncariae Cum Uncis, the weight of 540 Spica Prunellae that Caulis Spatholobi that number is 535, parts by weight are 540, parts by weight be 525 Semen Cassiae, parts by weight be 525 Concha Margaritifera, parts by weight be 305 Rhizoma Corydalis, parts by weight be the Herba Asari of 75, described capsule shells includes that parts by weight are 200 Gelatin, parts by weight be the pure water of 220.
Described blood-nourishing and brain-refreshing soft capsule, described content includes that Radix Angelicae Sinensis that parts by weight are 253.5, parts by weight are Radix Rehmanniae Preparata, parts by weight that the Radix Paeoniae Alba that the Rhizoma Chuanxiong of 253.5, parts by weight are 202.7, parts by weight are 202.7 are the hook of 506.8 Spica Prunellae that Caulis Spatholobi that rattan, parts by weight are 506.8, parts by weight are 506.8, parts by weight are Semen Cassiae, the weight of 506.8 Amount number be 506.8 Concha Margaritifera, parts by weight be 253.3 Rhizoma Corydalis, parts by weight be the Herba Asari of 50.5, described capsule Shell includes that gelatin that parts by weight are 200, parts by weight are the pure water of 220.
The preparation method of the blood-nourishing and brain-refreshing soft capsule that one of a kind of claim 1-4 is described, this comprises the steps:
(1) process of raw material: by Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Ramulus Uncariae Cum Uncis, Caulis Spatholobi, Spica Prunellae, Semen Cassiae, Concha Margaritifera, prolong Rhizoma Corydalis, Herba Asari carry out selected respectively, by the ratio of weight and number of one of claim 1-4, and precise, standby；
(2) powder makes: by the Radix Angelicae Sinensis described in step (1), Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Ramulus Uncariae Cum Uncis, Caulis Spatholobi, Spica Prunellae, Semen Cassiae Son, Concha Margaritifera, Rhizoma Corydalis, Herba Asari, add triploid accumulated amount soak by water three times the most respectively, collects volatile oil, each 2 hours, closes And filtrate, and to be evaporated to relative density be 1.1, adds soluble starch by extractum amount with certain proportion while hot, extractum: can Soluble starch=25:1, after stirring, is spray-dried, is ground into 120 mesh powder；
(3) prepared by capsule: the powder that will prepare in step (2), joins 40 DEG C of edible vegetable oils of 3 times of volumes, and described plants Thing oil is Semen Maydis or soybean salad oil, and adds the volatile oil of extraction, after carrying out homogenizing with colloid mill, under being stirred continuously, The soft capsule that content is 0.2-0.4 gram is made with coloured or opaque gelatin.
The invention has the beneficial effects as follows:
The prescription that blood-nourishing and brain-refreshing soft capsule of the present invention uses uses for many years, and determined curative effect has for the head caused by blood-deficiency leading to hyperactivity of the liver Dizziness, susceptible to lose temper due to restlessness, insomnia and dreamful sleep bitterly！Use the reasonable treating both the principal and secondary aspects of a disease of scientific formula, effect be better than current all similar commercially available and Clinical prods medicine.
Blood-nourishing and brain-refreshing soft capsule of the present invention uses current state-of-the-art soft capsule technology, coloured or opaque by seal Gelatin capsule material, the active composition and effectiveness highly volatile of inclusion content there is promoting flow of QI and blood, fragrance by wind pain relieving drug action Volatile oil, soft capsule can protect the steady quality of content activity composition and effectiveness effectively, and in added and compared containing linoleic acid Many vegetable oil (Semen Maydis or soybean salad oil), all have certain oxidation resistance, also can effectively protect various medical material matter The stability of amount.
Present invention purpose clinically nourishes blood suppressing the hyperactive liver, promoting blood circulation to remove obstruction in the collateral.For the headache caused by blood deficiency and excessive liver-YANG, stagger, Susceptible to lose temper due to restlessness, insomnia and dreamful sleep.
Detailed description of the invention:
Embodiment 1:
A kind of blood-nourishing and brain-refreshing soft capsule, its composition includes: capsule shells, has content, described content in described capsule shells Thing include parts by weight be the Radix Angelicae Sinensis of 200-300, parts by weight be the Rhizoma Chuanxiong of 210-285, parts by weight be the white of 170-225 Chinese herbaceous peony, parts by weight be the Radix Rehmanniae Preparata of 175-230, parts by weight be the Ramulus Uncariae Cum Uncis of 455-540, parts by weight be the Sanguis Gallus domesticus of 460-535 Rattan, parts by weight be the Spica Prunellae of 485-540, parts by weight be the Semen Cassiae of 475-525, parts by weight be the treasure of 475-525 Pearl oyster, parts by weight be the Rhizoma Corydalis of 220-305, parts by weight be the Herba Asari of 35-75, described capsule shells includes parts by weight Gelatin, parts by weight for 180-200 are the pure water of 210-220.
Embodiment 2:
According to the blood-nourishing and brain-refreshing soft capsule described in embodiment 1, described content includes Radix Angelicae Sinensis, the weight that parts by weight are 200 The Radix Paeoniae Alba that Rhizoma Chuanxiong that number is 210, parts by weight are 170, parts by weight be 175 Radix Rehmanniae Preparata, parts by weight be the hook of 455 Spica Prunellae that Caulis Spatholobi that rattan, parts by weight are 460, parts by weight are 485, parts by weight are Semen Cassiae, the parts by weight of 475 Be 475 Concha Margaritifera, parts by weight be 220 Rhizoma Corydalis, parts by weight be the Herba Asari of 35, described capsule shells includes weight portion Number be 180 gelatin, parts by weight be the pure water of 210.
Embodiment 3:
According to the blood-nourishing and brain-refreshing soft capsule described in embodiment 1, described content includes Radix Angelicae Sinensis, the weight that parts by weight are 300 The Radix Paeoniae Alba that Rhizoma Chuanxiong that number is 285, parts by weight are 225, parts by weight be 230 Radix Rehmanniae Preparata, parts by weight be the hook of 540 Spica Prunellae that Caulis Spatholobi that rattan, parts by weight are 535, parts by weight are 540, parts by weight are Semen Cassiae, the parts by weight of 525 Be 525 Concha Margaritifera, parts by weight be 305 Rhizoma Corydalis, parts by weight be the Herba Asari of 75, described capsule shells includes weight portion Number be 200 gelatin, parts by weight be the pure water of 220.
Embodiment 4:
According to the blood-nourishing and brain-refreshing soft capsule described in embodiment 1, described content includes Radix Angelicae Sinensis, the weight that parts by weight are 253.5 Amount number be 253.5 Rhizoma Chuanxiong, parts by weight be 202.7 the Radix Paeoniae Alba, parts by weight be 202.7 Radix Rehmanniae Preparata, parts by weight be Spica Prunellae, parts by weight that Caulis Spatholobi that the Ramulus Uncariae Cum Uncis of 506.8, parts by weight are 506.8, parts by weight are 506.8 are 506.8 Rhizoma Corydalis, parts by weight that Concha Margaritifera that Semen Cassiae, parts by weight are 506.8, parts by weight are 253.3 are the Herba Asari of 50.5, Described capsule shells includes that gelatin that parts by weight are 200, parts by weight are the pure water of 220.
Embodiment 5:
The preparation method of the blood-nourishing and brain-refreshing soft capsule that one of a kind of claim 1-4 is described, this comprises the steps:
(1) process of raw material: by Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Ramulus Uncariae Cum Uncis, Caulis Spatholobi, Spica Prunellae, Semen Cassiae, Concha Margaritifera, prolong Rhizoma Corydalis, Herba Asari carry out selected respectively, by the ratio of weight and number of one of claim 1-4, and precise, standby；
(2) powder makes: by the Radix Angelicae Sinensis described in step (1), Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Ramulus Uncariae Cum Uncis, Caulis Spatholobi, Spica Prunellae, Semen Cassiae Son, Concha Margaritifera, Rhizoma Corydalis, Herba Asari, add triploid accumulated amount soak by water three times the most respectively, collects volatile oil, each 2 hours, closes And filtrate, and to be evaporated to relative density be 1.1, adds soluble starch by extractum amount with certain proportion while hot, extractum: can Soluble starch=25:1, after stirring, is spray-dried, is ground into 120 mesh powder；
(3) prepared by capsule: the powder that will prepare in step (2), joins 40 DEG C of edible vegetable oils of 3 times of volumes, and described plants Thing oil is Semen Maydis or soybean salad oil, and adds the volatile oil of extraction, after carrying out homogenizing with colloid mill, under being stirred continuously, The soft capsule that content is 0.2-0.4 gram is made with coloured or opaque gelatin.
Embodiment 6:
According to the blood-nourishing and brain-refreshing soft capsule described in embodiment 1, described blood-nourishing and brain-refreshing soft capsule enters pharmacology and toxicological experiment shows: Be a kind of toxicity low, to body without the medicine of any obvious toxic-side effects.Experimentation is as follows:
(1) acute toxicity test:
Its mouse oral median lethal dose(LD 50) (LD50) mensuration: taking kunming mouse 50, body weight 18-21g/ only, is randomly divided into 5 groups, often group 10.Before test after fasting 10 h, with blood-nourishing and brain-refreshing soft capsule, (prepared by Heilongjiang University's Life Science College Lot number 20151011) capsule herb liquid 1 times/day, each group respectively with 0.01ml/ 10g, 0.02 ml/10g, 0.03 ml/ 10g, 0.04 ml/10g, 0.05 ml/10g dosage, is diluted to volume 1.00ml administered by oral gavage with Semen Maydis oil respectively.It is administered Rear observation 1 week, the poisoning symptom of record animal and death condition.LD is calculated according to animal dead situation50。
The mensuration of day 1 maximum tolerated dose (MTD): take kunming mouse 20, body weight 18-22 g/ is only.Clear with nourishing blood The Cmax 0.5ml/10g (crude drug 0.02g/ mL) of brain soft capsule herb liquid gavage.Hereafter Continuous Observation 7 d, this phase Between allow mice ad lib and drinking-water.
(2) subacute toxicity test test method:
Female Wistar rat 60, body weight 120-150 g/ only, after raising 5 d in advance, is randomly divided into 4 groups, often organizes 15 Only.I group is matched group, and II, III, IV group is medication group.Medication group is respectively with blood-nourishing and brain-refreshing soft capsule herb liquid 0.2mL (1/ 10 MTD), the dosage of 0.67 mL (1/ 3MTD) and 2mL (MTD) gavages, successive administration 60 d;Matched group is given Give the purified water of 1mL.(note: rat MTD is 2ml the liver benefiting soft capsules capsule herb liquid)
Observe every day, record the mental status of animal, feeding activities and defecation situation, weigh weekly 1 time.Before administration After off-test, taking a blood sample in rat tails, whole blood makees blood routine examination, and biochemical indicator detection made by serum.After off-test, solve Cuing open animal, the pathological changes of internal organs is respectively organized in perusal;Weigh the wet of main organs (heart, liver, spleen, lungs, kidney) Weight, and calculate the organ coefficient (organ coefficient=internal organs weight in wet base/body weight × 100) of each internal organs.
Result of the test
Owing to its mouse oral median lethal dose(LD 50) experiment mice is without death.So carrying out the mice maximum tolerated dose of oral 1 time on the 1st Algoscopy.Maximum tolerated dose MTD that 1 day of mice is oral 1 time is, none animal dead in 7 d, and mice food ration Normally, body weight increases, and dorsal body setae is glossy, submissive, without loose stool and other Novel presentations.It is clinical that mice maximum tolerated dose is equivalent to people 227.61 times of dosage (146.35g crude drug amount/kg).Illustrate that blood-nourishing and brain-refreshing soft capsule is the preferable medicine of safety.
Acute toxicity test in mice is affected by table 1 blood-nourishing and brain-refreshing soft capsule
Note: "+" represent have exception, "-" to represent without exception
The impact (.X ± S) that rat is increased weight by table 2 blood-nourishing and brain-refreshing soft capsule
Subacute toxicity test: activities in rats, appetite, activity, hair color and fecaluria no abnormality seen during ordinary circumstance test.Experiment Showing, the growth promoter of each medication treated animal compares no significant difference with matched group.Illustrate that blood-nourishing and brain-refreshing soft capsule is to rat Growth promoter has no adverse effects.
Blood-nourishing and brain-refreshing soft capsule is the conventional and impact of Biochemical Indices In Serum on rat serum, and each group rat serum is conventional and serum is raw Change and compare without significant difference (P > 0. 05) between index.Show that blood-nourishing and brain-refreshing soft capsule is to various blood cells, liver function Have no adverse effects with renal function.
The impact (X ± S) on rat serum conventional index of the table 3 blood-nourishing and brain-refreshing soft capsule
The impact (.X ± S) on rat blood serum biochemical indicator of the table 4 blood-nourishing and brain-refreshing soft capsule
The impact (X ± S g) on Rats Organs and Tissues coefficient of the table 5 blood-nourishing and brain-refreshing soft capsule
Blood-nourishing and brain-refreshing soft capsule the results are shown in Table 4 to the impact of Rats Organs and Tissues coefficient, comparing difference between each group Rats Organs and Tissues coefficient Not notable (P > 0. 05).Show that blood-nourishing and brain-refreshing soft capsule parenchymatous organ main to rat is without obvious detrimental effect.
The detection explanation blood-nourishing and brain-refreshing soft capsule of routine blood test is to the various hemocytees of rat and bone marrow hematogenesis function invariably Good impact;Detection to serum alkaline phosphatase, glutamic oxaloacetic transaminase, GOT, total protein, albumin and creatinine shows, blood-nourishing and brain-refreshing Soft capsule on the liver function of rat without impact;Serum urea nitrogen level is the important indicator of reflection renal function, and testing result shows It changed within normal range, renal function no abnormality seen, illustrated to have no adverse effects renal function.Organ coefficient is anti-in toxicology Reflect tested material to the sensitive of some organ injury degree and effective index, result show blood-nourishing and brain-refreshing soft capsule to the heart, liver, The harmless effects of parenchymatous organ such as spleen, lung and kidney.Result of the test shows that blood-nourishing and brain-refreshing soft capsule toxicity ratio is relatively low, can ensure that and faces Bed safe handling.
Blood-nourishing and brain-refreshing soft capsule can use the transparent and opaque capsule material of different colours, can covering smell effectively, side Just patient, it is also possible to stamp word or symbol in capsule material, adds the aesthetic feeling of outward appearance, the temperament and interest taken and be easy to identify, carry High quality and class.
Pharmacological research (1) result clearly indicates that: blood-nourishing and brain-refreshing soft capsule can be effectively improved drug-induced rat pharmacological model Physiochemical indice physical signs, can prevent rat serum Hemorheological Indexes abnormal effectively, effect and taking dose present certain just Dependency relation.The effective promoting blood circulation to remove obstruction in the collateral of blood-nourishing and brain-refreshing soft capsule, prevents due to the abnormal caused relevant disease of blood viscosity Occur, and prove that blood-nourishing and brain-refreshing soft capsule effect is significantly better than identical prescription blood-nourishing and brain-refreshing granules.
Pharmacological evaluation (1): blood-nourishing and brain-refreshing soft capsule impact rheol on rat serum
Take body weight 150-200g, healthy Wistar rat 110, after adaptability raises one week, be divided into 7 groups by often organizing 15, point Other labelling, if:
Intact animal's blank group (group I): pure water gavage 2ml/, tid, 7d.
" blood-nourishing and brain-refreshing soft capsule " high dose group (group II): 15 rats, by raw medicine calculation 6996mg.kg-1, with jade Rice salad oil is diluted to 2ml, gavages tid, 7d.
Dosage group (group III) in " blood-nourishing and brain-refreshing soft capsule ": 15 rats, by raw medicine calculation 3996mg.kg-1, use Semen Maydis salad oil is diluted to 2ml, gavages, tid, 7d.
" blood-nourishing and brain-refreshing soft capsule " low dose group (group IV): 15 rats, by raw medicine calculation 10mg.kg-1, with jade Rice salad oil is diluted to 2ml, gavages, tid, 7d.
Blood-nourishing and brain-refreshing granules (group V): 1ml.kg-1, blood-nourishing and brain-refreshing granules (Tasly Pharmaceutical Group Co., Ltd. Lot number: 150525 specification 4g/ bag/15 bag/box) 3996mg.kg-1, by dissolved in purified water, it is diluted to 2ml, gavages tid, 7d.
Pathological model group (group VI): 15 rats, pure water gavage 2ml/, tid, 7d.
Positive control drug group (group VII): 20mg(nimodipine) .kg-1, dissolve with distilled water, be diluted to 2ml, gavage, tid,7d。
In addition to intact animal's matched group (group I), remaining 6 groups (groups II, III, IV, V, VI, VII) are subcutaneous in the 7th day Injection adrenalin hydrochloride injection 0.08ml/100g, once, twice, is dipped in frozen water totally for every 4 hours therebetween by rat 5min, stopping feeding is to second day, and each group takes blood with control rats every disconnected stem respectively, is added to the burning of a small amount of heparin sodium Cup, concussion is uniformly.Measure blood rheology parameter.In experimentation, viewing test rat behavior, diet, outward appearance, row at any time Let out, body weight, the situation such as death, if any death, dissect immediately, observe internal organs situation.
Table 6: blood-nourishing and brain-refreshing soft capsule and blood-nourishing and brain-refreshing granules are on comparing that rat serum rheology affects
Note: compared with matched group, ▲ P < 0.01, ▲ ▲ P < 0.05, compared with pathological model group * P < 0.01, * * P < 0.05
Result shows:
1) accurately, whole experimental science is reasonable for experimental design positive controls, pathological model group real result.Blood-nourishing and brain-refreshing flexible glue Capsule is tested each group of biochemical indicator and be there is significant difference with matched group result.
) be can be seen that blood-nourishing and brain-refreshing soft capsule high, medium and low dosage group, positive controls, matched group by experimental result, supported Serum brain soft capsule group all with pathological model group, Plasma Viscosity, whole blood viscosity high, medium and low shear value, whole blood reduced viscosity, Significant difference is there is on the biochemical indicators such as packed cell volume.
) blood-nourishing and brain-refreshing granules experimental group and blood-nourishing and brain-refreshing soft capsule high, medium and low dosage group all can be obviously improved rat blood Liquid biochemical indicator, and there was no significant difference (P ＞ 0.05) with blood-nourishing and brain-refreshing granules experimental group.
Pharmacological evaluation (2): the blood-nourishing and brain-refreshing soft capsule impact on mouse writhing analgesic experiment
Take body weight 20-25g, healthy LACA mice 110, after adaptability raises one week, be divided into 7 groups by often organizing 15, mark respectively Note, if:
Intact animal's blank group (group I): pure water gavage 1ml/, tid, 7d.
" blood-nourishing and brain-refreshing soft capsule " high dose group (group II): 15 mices, by raw medicine calculation 9854mg.kg-1, with jade Rice salad oil is diluted to 1ml, gavages tid, 7d.
Dosage group (group III) in " blood-nourishing and brain-refreshing soft capsule ": 15 mices, by raw medicine calculation 5854mg.kg-1, use Semen Maydis salad oil is diluted to 2ml, gavages, tid, 7d.
" blood-nourishing and brain-refreshing soft capsule " low dose group (group IV): 15 mices, by raw medicine calculation 1854mg.kg-1, use Semen Maydis salad oil is diluted to 1ml, gavages, tid, 7d.
Blood-nourishing and brain-refreshing granules (group V): 15 mices, blood-nourishing and brain-refreshing granules (Tasly Pharmaceutical Group Co., Ltd. Lot number: 150525 specification 4g/ bag/15 bag/box) 5854mg.kg-1, by dissolved in purified water, it is diluted to 1ml, gavages tid, 7d.
Pathological model group (group VI): 15 mices, pure water gavage 1ml/, tid, 7d.
Positive control drug group (group VII): after salad oil gavages tid 1ml.7d.Lumbar injection morphine 0.015mg.kg-1
After 7 days, by matched group (group I) 0.2ml/ normal saline of lumbar injection, additionally by other test each group (group II, III, IV, V, VI, VII) lumbar injection 0.2ml/ only 0.5% acetic acid, each group mouse writhing reaction times in observing 15min immediately, And statistical.(the results are shown in Table two)
Result shows:
1) accurately, whole experimental science is reasonable for experimental design positive controls, pathological model group real result.Blood-nourishing and brain-refreshing flexible glue Capsule is tested each group of biochemical indicator and be there is significant difference with matched group result.
) be can be seen that blood-nourishing and brain-refreshing soft capsule high, medium and low dosage group, positive controls, matched group by experimental result, supported Serum brain soft capsule group all with pathological model group, there is significant difference in mouse writhing reaction times.
) blood-nourishing and brain-refreshing granules experimental group and blood-nourishing and brain-refreshing soft capsule high, medium and low dosage group all can be obviously improved mouse writhing Number of times, and there was no significant difference (P ＞ 0.05) with blood-nourishing and brain-refreshing granules experimental group.
Table 7 blood-nourishing and brain-refreshing soft capsule and the blood-nourishing and brain-refreshing granules comparison (x ± s, n=15) to the analgesic activity of mice
Note: compared with matched group, ▲ P < 0.01
Pharmacological research (2) result clearly indicates that: blood-nourishing and brain-refreshing soft capsule can be effectively improved drug-induced mice analgesia writhing pharmacology Model physiochemical indice physical signs, can be effectively reduced mice analgesia writhing Indexes Abnormality, and effect and taking dose present necessarily Positive correlation.The effective promoting blood circulation to remove obstruction in the collateral of blood-nourishing and brain-refreshing soft capsule, prevents due to the abnormal caused relevant disease of nervus centralis Sick generation, and prove that blood-nourishing and brain-refreshing soft capsule effect is significantly better than identical prescription blood-nourishing and brain-refreshing granules.
Blood-nourishing and brain-refreshing soft capsule mainly uses pure natural plant extract, and it is solvable to have causing resuscitation with aromatic drugs, blood circulation promoting and blood stasis dispelling Property aromatic oil composition, homogenizing human body in the vegetable oil easily absorbed easily absorbs, and toxic and side effects is low, meets very much modern international doctor Learning the trend for the treatment of, market prospect is considerable.

Claims (5)

1. a blood-nourishing and brain-refreshing soft capsule, its composition includes: capsule shells, has content, it is characterized in that in described capsule shells: Described content include parts by weight be the Radix Angelicae Sinensis of 200-300, parts by weight be that the Rhizoma Chuanxiong of 210-285, parts by weight are The Radix Paeoniae Alba of 170-225, parts by weight be the Radix Rehmanniae Preparata of 175-230, parts by weight be that the Ramulus Uncariae Cum Uncis of 455-540, parts by weight are The Caulis Spatholobi of 460-535, parts by weight be the Spica Prunellae of 485-540, parts by weight be the Semen Cassiae of 475-525, parts by weight For the Concha Margaritifera of 475-525, parts by weight be the Rhizoma Corydalis of 220-305, parts by weight be the Herba Asari of 35-75, described capsule Shell include parts by weight be the gelatin of 180-200, parts by weight be the pure water of 210-220.
Blood-nourishing and brain-refreshing soft capsule the most according to claim 1, is characterized in that: described content includes that parts by weight are The Radix Paeoniae Alba that Rhizoma Chuanxiong that the Radix Angelicae Sinensis of 200, parts by weight are 210, parts by weight are 170, parts by weight are Radix Rehmanniae Preparata, the weight of 175 Caulis Spatholobi that Ramulus Uncariae Cum Uncis that number is 455, parts by weight are 460, parts by weight be 485 Spica Prunellae, parts by weight be 475 certainly Rhizoma Corydalis, parts by weight that Concha Margaritifera that pine torch, parts by weight are 475, parts by weight are 220 are the Herba Asari of 35, described glue Softgel shell includes that gelatin that parts by weight are 180, parts by weight are the pure water of 210.
Blood-nourishing and brain-refreshing soft capsule the most according to claim 1, is characterized in that: described content includes that parts by weight are The Radix Paeoniae Alba that Rhizoma Chuanxiong that the Radix Angelicae Sinensis of 300, parts by weight are 285, parts by weight are 225, parts by weight are Radix Rehmanniae Preparata, the weight of 230 Caulis Spatholobi that Ramulus Uncariae Cum Uncis that number is 540, parts by weight are 535, parts by weight be 540 Spica Prunellae, parts by weight be 525 certainly Rhizoma Corydalis, parts by weight that Concha Margaritifera that pine torch, parts by weight are 525, parts by weight are 305 are the Herba Asari of 75, described glue Softgel shell includes that gelatin that parts by weight are 200, parts by weight are the pure water of 220.
Blood-nourishing and brain-refreshing soft capsule the most according to claim 1, is characterized in that: described content includes that parts by weight are The Radix Paeoniae Alba, parts by weight that Rhizoma Chuanxiong that the Radix Angelicae Sinensis of 253.5, parts by weight are 253.5, parts by weight are 202.7 are the Radix Rehmanniae Preparata of 202.7 Caulis Spatholobi that Ramulus Uncariae Cum Uncis that yellow, parts by weight are 506.8, parts by weight are 506.8, parts by weight are Spica Prunellae, the weight of 506.8 Concha Margaritifera that Semen Cassiae that number is 506.8, parts by weight are 506.8, parts by weight are Rhizoma Corydalis, the parts by weight of 253.3 Being the Herba Asari of 50.5, described capsule shells includes that gelatin that parts by weight are 200, parts by weight are the pure water of 220.
5. a preparation method for the blood-nourishing and brain-refreshing soft capsule that one of claim 1-4 is described, is characterized in that: this includes walking as follows Rapid:
(1) process of raw material: by Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Ramulus Uncariae Cum Uncis, Caulis Spatholobi, Spica Prunellae, Semen Cassiae, Concha Margaritifera, prolong Rhizoma Corydalis, Herba Asari carry out selected respectively, by the ratio of weight and number of one of claim 1-4, and precise, standby；
(2) powder makes: by the Radix Angelicae Sinensis described in step (1), Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Ramulus Uncariae Cum Uncis, Caulis Spatholobi, Spica Prunellae, Semen Cassiae Son, Concha Margaritifera, Rhizoma Corydalis, Herba Asari, add triploid accumulated amount soak by water three times the most respectively, collects volatile oil, each 2 hours, closes And filtrate, and to be evaporated to relative density be 1.1, adds soluble starch by extractum amount with certain proportion while hot, extractum: can Soluble starch=25:1, after stirring, is spray-dried, is ground into 120 mesh powder；
(3) prepared by capsule: the powder that will prepare in step (2), joins 40 DEG C of edible vegetable oils of 3 times of volumes, and described plants Thing oil is Semen Maydis or soybean salad oil, and adds the volatile oil of extraction, after carrying out homogenizing with colloid mill, under being stirred continuously, The soft capsule that content is 0.2-0.4 gram is made with coloured or opaque gelatin.
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1593634A (en) * 2004-06-25 2005-03-16 张晴龙 Blood nourishing, brain refreshing orally disintegrating tablet and its preparation process
CN103877241A (en) * 2012-12-21 2014-06-25 天士力制药集团股份有限公司 Medicine for treating headache
CN105168887A (en) * 2015-10-20 2015-12-23 黑龙江大学 Capsule capable of tonifying kidney and nourishing vitality and preparation process

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1593634A (en) * 2004-06-25 2005-03-16 张晴龙 Blood nourishing, brain refreshing orally disintegrating tablet and its preparation process
CN103877241A (en) * 2012-12-21 2014-06-25 天士力制药集团股份有限公司 Medicine for treating headache
CN105168887A (en) * 2015-10-20 2015-12-23 黑龙江大学 Capsule capable of tonifying kidney and nourishing vitality and preparation process

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