CN105770307A - Traditional Chinese medicine composition for preventing and treating ascites syndrome in poultry, feed and application thereof - Google Patents
Traditional Chinese medicine composition for preventing and treating ascites syndrome in poultry, feed and application thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for preventing and treating ascites syndrome in poultry, a feed additive containing the traditional Chinese medicine composition and an application thereof, and belongs to the field of veterinary drug. The traditional Chinese medicine composition contains an active component, which is prepared from ligusticum wallichii, poria cocos, ginseng leaf, lobedfruit schizocapsarhizome and plantain seed. The traditional Chinese medicine composition is used for preventing and treating ascites syndrome in broilers, has remarkable effects, has no pollution or residue, has no toxic or side effect, and overcomes problems of residue and drug resistance which are caused by western medicine.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for preventing and treating fowl ascites syndrome, containing the feed additive of this Chinese medicine composition, feedstuff and application thereof, belong to field of veterinary.
Background technology
Ascites syndrome in broilers, also known as " Broiler High Pulmonary syndrome (pulmonaryhypertensionsyndrome, PHS) ", is the big disease endangering current broiler breeding industry.This disease sees nineteen forty-six U.S. the earliest about the report of poult generation ascites syndrome.The report that China started this disease occur from 1987, this disease all can occur the whole year, especially with winter multiple, high altitude localities is more multiple than low altitude area, has mass-sending.The cause of disease is complex, and it is ill that the factor such as anoxia, cold, coop ventilation are bad, vitamin E deficiency leads to broiler, and obvious ascites, right cardiectasis occurs in sick chicken, pulmonary congestion, edema and the pathological changes such as liver, kidney, being mainly in 4 ~ 6 week old broiler chicken, its mortality rate 1 ~ 30% not etc., is not suffered heavy losses.In recent years, this disease M & M is in rising trend, and Infected regions constantly expands, and directly affects the economic benefit of broiler breeding industry.
In recent years, along with its people's close attention to state food safety, herbal medicine receives increasing attention and application.Herbal medicine as pure natural medical, both can fundamentally disease preventing and treating, promote growth of animal, the drug residue being detrimental to health will not be produced again, therefore develop a kind of medicine preventing and treating ascites syndrome in broilers significant.
Summary of the invention
It is an object of the invention to provide a kind of efficient, natural, safe Chinese medicine composition, can be used for preventing and treating ascites syndrome in broilers.The active component of this Chinese medicine composition is made up of Rhizoma Chuanxiong, Poria, Folium Ginseng, Rhizoma Schizocapsae Plantagineae, Semen Plantaginis, its good effect, low toxicity noresidue, environmental protection.
Another object of the present invention is to provide the preparation method and its usage of this Chinese medicine composition.
It is an object of the invention to be achieved through the following technical solutions:
The present invention is provided to the Chinese medicine composition of preventing and treating fowl ascites syndrome, it contains active component, and described active component is made up of Rhizoma Chuanxiong, Poria, Folium Ginseng, Rhizoma Schizocapsae Plantagineae, Semen Plantaginis.
Wherein, described active component is made up of the component of following weight parts: Rhizoma Chuanxiong 35 ~ 90 parts, 15 ~ 60 parts of Poria, Folium Ginseng 10 ~ 50 parts, Rhizoma Schizocapsae Plantagineae 10 ~ 45 parts, Semen Plantaginis 20 ~ 70 parts.
Further, described active component is made up of the component of following weight parts: Rhizoma Chuanxiong 40 ~ 80 parts, 20 ~ 50 parts of Poria, Folium Ginseng 10 ~ 40 parts, Rhizoma Schizocapsae Plantagineae 15 ~ 30 parts, Semen Plantaginis 20 ~ 60 parts.
Further, described active component is made up of the component of following weight parts: Rhizoma Chuanxiong 50 ~ 70 parts, 25 ~ 40 parts of Poria, Folium Ginseng 20 ~ 40 parts, Rhizoma Schizocapsae Plantagineae 20 ~ 30 parts, Semen Plantaginis 30 ~ 50 parts.
Wherein, described Chinese medicine composition can be made into powder, powder, granule, oral liquid or injection.
The preparation method that present invention also offers this Chinese medicine composition, comprises the steps:
1) weigh each raw material by weight, pulverize, sieve after mixing；
2) optionally, add 6 ~ 12 times amount distilled water decoct three times, each 1.5h, merge decoction liquor, filter, filtrate is concentrated in right amount, adds 1 ~ 5 times amount dehydrated alcohol, stirs, staticly settle 1 ~ 5h, filtering, filtrate is concentrated into extractum shape, and corresponding dosage form made by the corresponding pharmaceutically acceptable carrier of dried addition or adjuvant.
Chinese medicine composition of the present invention can as feed additive, add in fowl basal diet, can preventing and treating fowl ascites syndrome after feeding, therefore the present invention also provides for the feed additive containing described Chinese medicine composition and feedstuff, and described feedstuff includes premix material, concentrate feed and batch.
The Chinese medicine composition of the present invention can be used for preparing the medicine of fowl ascites syndrome.The composition principle of this Chinese medicine composition is: Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping；Poria promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming；Folium Ginseng tonifying QI to produce body fluid；Rhizoma Schizocapsae Plantagineae dissipating blood stasis for subsidence of swelling, anti-inflammatory analgetic；Semen Plantaginis eliminating dampness and diuresis.This prescription provides the benefit that, in side, Rhizoma Chuanxiong shares with Poria, has the magical effect of regulating qi to disperse stagnation dehumidifying and effect of being amusing.Semen Plantaginis eliminates body edematous condition, Folium Ginseng tonifying QI to produce body fluid with Rhizoma Schizocapsae Plantagineae detumescence dissipating blood stasis diuresis, promotes body healthy energy.Modern pharmacology research shows, Rhizoma Chuanxiong is treatment diseases of cardiovascular and cerebrovascular systems conventional Chinese medicine, expansible blood vessel, improves microcirculation, diastole pulmonary artery, reduces pulmonary artery pressure, resists myocardial ischemia, and in Poria, pachyman can be obviously enhanced body's immunity.From acting on focus at all, reach the effect for the treatment of both the principal and secondary aspects of a disease.
The advantage of the Chinese medicine composition of the present invention and having the beneficial effects that:
1) Chinese medicine composition of the present invention is to administer according to herbal medicine syndrome differentiation of formulas opinion to discuss prescription, and instant effect is evident in efficacy.
2) Chinese medicine composition of the present invention is used for preventing and treating ascites syndrome in broilers, overcomes residual, drug resistance problems that Western medicine produces.
3) Chinese medicine composition of the present invention is easy to use, and preparation technology is simple, can be made into powder, powder, granule, oral liquid and injection etc..
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
Embodiment 1
(1) raw material containing following weight parts is weighed:
Rhizoma Chuanxiong 45 parts, 30 parts of Poria, Folium Ginseng 20 parts, Rhizoma Schizocapsae Plantagineae 45 parts, Semen Plantaginis 35 parts.
(2), after each weight crude drug claimed in step (1) being pulverized, sieved, it is sufficiently mixed and makes powder.
Embodiment 2
(1) raw material containing following weight is weighed:
Rhizoma Chuanxiong 35 parts, 20 parts of Poria, Folium Ginseng 10 parts, Rhizoma Schizocapsae Plantagineae 15 parts, Semen Plantaginis 30 parts.
(2) by each raw material pulverizing, sieve after add 6 times amount distilled water decoct three times, each 1.5h, merges decoction liquor, filters, filtrate is concentrated in right amount, add 2 times amount dehydrated alcohol, stir, staticly settle 2h, filter, filtrate is concentrated into extractum shape, adds appropriate soluble starch and dextrin mix homogeneously, dries and makes powder (every 1g is equivalent to crude drug in whole 1g).
Embodiment 3
(1) raw material containing following weight parts is weighed:
Rhizoma Chuanxiong 40 parts, 50 parts of Poria, Folium Ginseng 30 parts, Rhizoma Schizocapsae Plantagineae 20 parts, Semen Plantaginis 45 parts.
(2) by each raw material pulverizing, sieve after add 12 times amount distilled water decoct three times, each 1.5h, merges decoction liquor, filters, filtrate is concentrated in right amount, add 3 times amount dehydrated alcohol, stir, staticly settle 3h, filter, filtrate is concentrated into extractum shape, adds appropriate soluble starch and dextrin mix homogeneously, dries and makes granule (every 1g is equivalent to crude drug in whole 1g).
Embodiment 4
(1) raw material containing following weight parts is weighed:
Rhizoma Chuanxiong 60 parts, 30 parts of Poria, Folium Ginseng 25 parts, Rhizoma Schizocapsae Plantagineae 20 parts, Semen Plantaginis 40 parts.
(2) by each raw material pulverizing, sieve after add 8 times amount distilled water decoct three times, each 1.5h, merges decoction liquor, filters, filtrate is concentrated in right amount, add 5 times amount dehydrated alcohol, stir, staticly settle 4h, filter, filtrate is concentrated into every ml containing primary crude drug 1.0g, adds suitable amount of sucrose, benzoic acid, ethyl hydroxybenzoate, makes oral liquid.
Embodiment 5
(1) raw material containing following weight parts is weighed:
Rhizoma Chuanxiong 50 parts, 25 parts of Poria, Folium Ginseng 20 parts, Rhizoma Schizocapsae Plantagineae 30 parts, Semen Plantaginis 30 parts.
(2) by each raw material pulverizing, sieve after add 10 times amount distilled water decoct three times, each 1.5h, merges decoction liquor, filters, filtrate is concentrated in right amount, add 5 times amount dehydrated alcohol, stir, staticly settle 5h, filter, it is concentrated into every ml containing primary crude drug 1.0g, adds appropriate benzoic acid, ethyl hydroxybenzoate, make injection.
The test example 1 Chinese medicine composition of the present invention clinical prophylactic performance to ascites syndrome in broilers
This test carries out in the dynamic Technical Research Center experimental animal room of protecting of big north agriculture, by manufacturing low-temperature cold ambient induced ascites syndrome in broilers.Select 4 week old healthy AA broiler 360, be randomly divided into 3 groups, often group 120.1st group is Chinese medicine composition of the present invention, adopts embodiment 1 to prepare, every 1g spice 1kg, free choice feeding；2nd group is control drug group, every 1g vitamin C spice 1kg, free choice feeding；3rd group is low temperature matched group, and without any medicine, other rearing conditions are completely the same.Reduce hen house temperature 1 ~ 2 DEG C every day on-test, room temperature 25 DEG C be progressively down to 8 ~ 12 DEG C, observe broiler symptom and record morbidity and the death condition of ascites syndrome in broilers.Morbidity broiler cardinal symptom is: lassitude, and feather is mixed and disorderly, and loss of appetite is slow in action, abdominal part enlargement, has pressed fluctuation；Cut open the inspection visible abdominal cavity of chicken of dying of illness and have a large amount of ascites, in brownish red, have fibrin clot, liver enlargement, pericardial effusion, right cardiectasis.Learn according to result, medicine group sickness rate 1.70% of the present invention, dead without broiler；Control drug group sickness rate 2.50%, mortality rate 0.83%；Low temperature matched group sickness rate 12.50%, mortality rate 11.67%.The M & M of medicine group of the present invention and control drug group is substantially less than low temperature matched group (P < 0.05), it was shown that Chinese medicine composition of the present invention can prevent ascites syndrome in broilers.Result is in Table 1.
The curative effect statistics of table 1 chemoprophylaxis ascites syndrome in broilers of the present invention
The test example 2 Chinese medicine composition of the present invention clinical therapeutic efficacy to ascites syndrome in broilers
This test carries out in the dynamic Technical Research Center experimental animal room of protecting of big north agriculture.Test selects 490 AA commercial meat birds to be randomly divided into 7 groups, often group 70.Participate in the experiment conventional before chicken 21 age in days raising；After 21 ages in days, the 1st group of broiler is still normally raised as room temperature matched group, and other are respectively organized hen house temperature and are progressively down to 12 DEG C by every day 1 ~ 2 DEG C by 25 DEG C；Simultaneously the 4th group, the 5th group with the 7th group of every kg feedstuff in add T3(3) 1.5mg is to bring out ascites syndrome in broilers.Observing broiler and occur listless, happiness is sleeping, dysstasia, and abdominal part expands etc. after symptom, and the 3rd group, the 4th group uses Chinese medicine composition of the present invention, adopts embodiment 2 to prepare, and every 1g is watered 1kg, continuous 6d, free drink-service；6th group, the 7th group as control drug group, every 5g vitamin C is watered 1kg, continuous 6d, free drink-service.2nd group as low temperature matched group, the 5th group as low temperature+T3Matched group is not administered and does not treat, and normally raises.Learning according to result, room temperature matched group sickness rate 2.86% and mortality rate 1.40%, low temperature+medicine group sickness rate 1.40% of the present invention and mortality rate 0.00%, low temperature+vitamin c group sickness rate 2.86% and mortality rate 1.40% are substantially less than low temperature matched group sickness rate 12.86% and mortality rate 11.43% (P < 0.05)；Low temperature+T3Matched group adds T3Making broiler sickness rate up to 30.0%, mortality rate is up to 28.57%；Low temperature+T3+ medicine group sickness rate 5.71% of the present invention and mortality rate 2.86%, low temperature+T3+ vitamin c group sickness rate 7.14% and mortality rate 4.29% are substantially less than low temperature+T3Matched group sickness rate 30.00% and mortality rate 28.57%(P < 0.05), greatly reduce broiler at cryogenic conditions and low temperature+T3Sickness rate under condition, it was shown that Chinese medicine composition of the present invention can treat ascites syndrome in broilers.Result is in Table 2.
The curative effect statistics of table 2 Drug therapy ascites syndrome in broilers of the present invention
The test example 3 Chinese medicine composition of the present invention clinical therapeutic efficacy to ascites syndrome in broilers
Langfang in Hebei Province raises in chicken farm 28 Day-old Broiler Chickens 500, and part broiler occurs listless, and slow on foot, dysstasia, abdominal part lands, and presents penguin shape, the phenomenons such as abdominal part expands, and feather is fluffy and disorderly, rapid breathing, diarrhoea.Cut open the seriously ill chicken of inspection and see that intraperitoneal has a large amount of brownish red or khaki ascites, limpid or be mixed with cellulosic fibrin clot；Liver enlargement congestion, pericardium has hydrops, and right ventricle is substantially expanded, and heart wall such as thickens at the symptom, is ascites syndrome in broilers after diagnosing.Picking body weight is close from which, and the typical chicken 135 of symptom is only divided into 3 groups, often group 45.1st group uses Chinese medicine composition of the present invention, adopts embodiment 3 to prepare, every 1g spice 1kg, free choice feeding, continuous 6d;2nd group is control drug group, every 5g vitamin C spice 1kg, free choice feeding, continuous 6d;3rd group is blank group, is not administered and does not treat, and other rearing conditions keep consistent.Do house internal and external environment health, timing sterilization, stronger ventilation well simultaneously.Learning according to result, medicine group cure rate 95.56% of the present invention and drug control group cure rate 93.33% are significantly higher than blank group cure rate 11.11%(P < 0.05).Show that Chinese medicine composition of the present invention can treat ascites syndrome in broilers, and therapeutic effect is better than control drug.Result is in Table 3.
The curative effect statistics of table 3 Drug therapy ascites syndrome in broilers of the present invention
The test example 4 Chinese medicine composition of the present invention clinical therapeutic efficacy to ascites syndrome in broilers
Broiler 850 newly enters in chicken farm in Hebei Shijiazhuang province, and most broiler occur that feather is fluffy and disorderly, look asthenia, dyspnea, is reluctant activity.Abdominal part expands, and in water bag shape, palpation has fluctuation, and skin of abdomen is thinning the symptom such as sends out cool.Cut open the inspection chicken that dies of illness and see abdominal part congestion and edema；Pericardial effusion, cardiac enlargement, seroperitoneum etc..Being divided into 3 groups after being isolated by broiler ill in chicken group, use Chinese medicine composition of the present invention for the 1st group, adopt embodiment 4 to prepare, 1ml is watered 1kg, free drink-service, normally raises；2nd group as drug control group, 5g vitamin C is watered 1kg, free drink-service, normally raises；As blank group, without any medicine, normally raising for 3rd group, other rearing conditions keep consistent.The healing number of every day entry group broiler and death toll, statistics cure rate and mortality rate.Learning according to result, medicine group cure rate 93.85% of the present invention and drug control group cure rate 92.31% are significantly higher than blank group cure rate 10.77%(P < 0.05).Show that Chinese medicine composition of the present invention can treat ascites syndrome in broilers.Result is in Table 4.
The curative effect statistics of table 4 Drug therapy ascites syndrome in broilers of the present invention
| Group Not | Quantity (only) | Cure number (only) | Death toll (only) | Cure rate (%) | Mortality rate (%) |
| Medicine group of the present invention | 65 | 61 | 4 | 93.85 | 6.15 |
| Control drug group | 65 | 60 | 5 | 92.31 | 7.69 |
| Blank group | 65 | 7 | 58 | 10.77 | 89.23 |
The above is only the preferred embodiment of the present invention; it should be pointed out that, for those skilled in the art, under the premise without departing from the technology of the present invention principle; can also making some improvements and modifications, these improvements and modifications also should be regarded as protection scope of the present invention.
Claims (8)
1., for preventing and treating a Chinese medicine composition for fowl ascites syndrome, it contains active component, and described active component is made up of Rhizoma Chuanxiong, Poria, Folium Ginseng, Rhizoma Schizocapsae Plantagineae, Semen Plantaginis.
2. Chinese medicine composition according to claim 1, it is characterised in that described active component is made up of the component of following weight parts: Rhizoma Chuanxiong 35 ~ 90 parts, 15 ~ 60 parts of Poria, Folium Ginseng 10 ~ 50 parts, Rhizoma Schizocapsae Plantagineae 10 ~ 45 parts, Semen Plantaginis 20 ~ 70 parts.
3. Chinese medicine composition according to claim 2, it is characterised in that described active component is made up of the component of following weight parts: Rhizoma Chuanxiong 40 ~ 80 parts, 20 ~ 50 parts of Poria, Folium Ginseng 10 ~ 40 parts, Rhizoma Schizocapsae Plantagineae 15 ~ 40 parts, Semen Plantaginis 20 ~ 60 parts.
4. Chinese medicine composition according to claim 3, it is characterised in that described active component is made up of the component of following weight parts: Rhizoma Chuanxiong 50 ~ 70 parts, 25 ~ 40 parts of Poria, Folium Ginseng 20 ~ 30 parts, Rhizoma Schizocapsae Plantagineae 20 ~ 30 parts, Semen Plantaginis 30 ~ 50 parts.
5. the Chinese medicine composition described in claim 1 ~ 4, it is characterised in that it is powder, powder, granule, oral liquid or injection.
6. a preparation method for the Chinese medicine composition described in any one of claim 1 ~ 5, comprises the steps:
1) weigh each raw material by weight, pulverize, sieve after mixing；
2) optionally, add 6 ~ 12 times amount distilled water decoct three times, each 1.5h, merge decoction liquor, filter, filtrate is concentrated in right amount, adds 1 ~ 5 times amount dehydrated alcohol, stirs, staticly settle 1 ~ 5h, filtering, filtrate is concentrated into extractum shape, and corresponding dosage form made by the corresponding pharmaceutically acceptable carrier of dried addition or adjuvant.
7. the application in the medicine of preparation fowl ascites syndrome of the Chinese medicine composition described in any one of claim 1 ~ 5.
8. contain the feed additive of Chinese medicine composition described in any one of claim 1 ~ 5, premix material, concentrate feed or batch.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106804978A (en) * | 2016-12-31 | 2017-06-09 | 新昌县鼎兴生物技术有限公司 | Prevent and treat the Chinese herbal feed additive of poultry diarrhea |
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| CN101653524A (en) * | 2009-08-06 | 2010-02-24 | 天津生机集团股份有限公司 | Traditional Chinese medicine composition for treating poulard abdominal dropsy and preparation method thereof |
| CN101972300A (en) * | 2010-08-25 | 2011-02-16 | 天津生机集团股份有限公司 | Chinese medicinal composition for treating broiler abdominal dropsy and preparation method thereof |
| CN104027503A (en) * | 2014-06-20 | 2014-09-10 | 湖州天健兽药有限公司 | Traditional Chinese medicine for treating broiler ascites |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2004043372A (en) * | 2002-07-12 | 2004-02-12 | Fancl Corp | Vasopressin receptor antagonist |
| CN101653524A (en) * | 2009-08-06 | 2010-02-24 | 天津生机集团股份有限公司 | Traditional Chinese medicine composition for treating poulard abdominal dropsy and preparation method thereof |
| CN101972300A (en) * | 2010-08-25 | 2011-02-16 | 天津生机集团股份有限公司 | Chinese medicinal composition for treating broiler abdominal dropsy and preparation method thereof |
| CN104027503A (en) * | 2014-06-20 | 2014-09-10 | 湖州天健兽药有限公司 | Traditional Chinese medicine for treating broiler ascites |
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| CN106804978A (en) * | 2016-12-31 | 2017-06-09 | 新昌县鼎兴生物技术有限公司 | Prevent and treat the Chinese herbal feed additive of poultry diarrhea |
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