CN105770290A - Compound polyinosinic cell injection for treating verruca vulgaris and herpes zoster and application thereof - Google Patents
Compound polyinosinic cell injection for treating verruca vulgaris and herpes zoster and application thereof Download PDFInfo
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Abstract
The invention relates to a compound polyinosinic cell injection for treating the verruca vulgaris and the herpes zoster.The compound injection is prepared from, by weight, 0.2-2 parts of polyinosinic cell, 20-40 parts of radix isatidis, 20-40 parts of folium isatidis, 20-40 parts of rhizoma cyperi, 20-40 parts of herba equiseti hiemalis and 20-40 parts of commelina communis L..The compound polyinosinic cell injection has a precise treatment effect on the verruca vulgaris and the herpes zoster, a patient can inject the injection for treatment by himself/herself, and the injection is convenient to use and low in cost.
Description
Technical field
The present invention relates to pharmaceutical technology field, specifically, be a kind of to treat answering of verruca vulgaris and herpes zoster
Side's poly IC syringe and application thereof.
Background technology
Poly IC is the double-stranded RNA polymer of Prof. Du Yucang, is by the general acid of poly flesh and poly born of the same parents general acid group
The acid chains such as the bifilar multinuclear become.Poly IC is the conventional common antiviral agent for the treatment of viral disease, it was reported that
Poly IC is efficient interferon inducer crude drug, and after injection, 2-12h just can make to occur in blood of human body substantial amounts of interference
Element, makes the anti-virus ability of cell be obviously enhanced, has Culture in vitro effect simultaneously, stimulate and promote
The activity of cell, thus strengthen the ability removing virus infected cell.Poly IC have the strongest Hangzhoupro virus,
Antitumor and immunoregulation effect, is the maximally effective interferon inducer of Prof. Du Yucang, is widely used in people
Cure clinical viral disease and the prevention of ND and treatment.
Verruca vulgaris is by being mainly in finger, position, the back of the hand foot edge caused by human papilloma virus (HPV)
A kind of little neoplasm of skin superficial, its rough surface is uneven, in corn shape, general no conscious sympton, this disease
Motherland's medical science is referred to as " verruca vulgaris ", " withered muscle arrow ", and because of its neoplasm, face is coarse is commonly called as " thorn wart " as stung.
At present, western medicine generally includes physical damage for the treatment of verruca vulgaris, such as freezing, surgical excision titanium dioxide
Carbon laser；Chemical depletion, such as salicylic acid, podophyllin, cantharidin etc. and immune modulating treatment, such as interference
The methods such as element, Tretinoin, contact immunization therapy.The most any methods for the treatment of, has certain limitation
Property, skin damages unavoidable recurrence.Herpes zoster, also known as acute herpes zoster (AHZ), is sick by varicella-zoster
A kind of common skin mucosal disease that poison (VZV) causes, virus is mainly invaded spinal cord and nerve roots, is caused nerve
The inflammatory of cell changes, and shows as varicella or subclinical infection during patient primary infection VZV, and then virus is latent
Lie prostrate in dorsal root or neuromere.When patient immune function is gone down, VZV latent virus is activated,
Descending along sensory nerve axle, involve nerve, skin is inflamed.The feature of VZV is collection occur the most suddenly
Bunch property blister, is arranged in banding, occurs along peripheral nerve distributed area, side, is often accompanied by the most neural shouting pain
Or pain such as fire burns, and neighbouring enlargement of lymph nodes occurs.
Prior art discloses multiple treatment verruca vulgaris and the medicine of herpes zoster, such as Hubei College Of Traditional Chinese Medicine 2009
" injection of poly IC degree coordinates oral medicinal herb treatment flat wart clinical practice to grind to the shown academic dissertation in April in year
Study carefully ", use poly IC acupoint injection therapy to coordinate oral medicinal herb treatment flat wart, treatment group gives poly IC injection
Liquid acupoint injection therapy, each 2ml, 2 times a week, give simultaneously Chinese medicine dispel defect soup decoction take orally.China is specially
Profit 200810014144.7 discloses a kind of Chinese medicine external medicament treating verruca vulgaris and preparation method thereof, by with
The raw material of lower weight portion is made: crow egg-shaped thing 15-20 part, Drilgrass 15-20 part, coix seed 15-30 part,
Coptis 10-15 part, Radix Isatidis 15-30 part, rhizoma atractylodis 10-0 part, umbellate pore furgus 12-24 part, dandelion 15-30
Part, dragon's blood 15-18 part, indigo naturalis 10-12 part, borneol 6-10 part.Patent document CN1672698,
CN1247068, CN1513476, CN1142387 etc. also disclose that some Chinese medicine preparations, and these medicaments are all
There is certain curative effect, but effect of these formula material medicines is poor, or toxicity is bigger.Therefore, people are to curative effect
Preferably the traditional Chinese medicine for outer use for the treatment of disease of skin still suffers from demand.Up to now, the most do not find any
Report for the present invention.
Summary of the invention
It is an object of the invention to for deficiency of the prior art, it is provided that one treats verruca vulgaris and herpes zoster
Compound Polyinosinic injection.
Another purpose of the present invention is to provide the preparation method of compound Polyinosinic injection described above.
Another the purpose of the present invention is to provide the purposes of compound Polyinosinic injection described above.
Fourth object of the present invention is to provide a kind of pharmaceutical composition treating verruca vulgaris and herpes zoster.
5th purpose of the present invention is to provide a kind of compound poly IC note treating verruca vulgaris and herpes zoster
Emitter
For achieving the above object, the present invention adopts the technical scheme that:
A kind of compound Polyinosinic injection treating verruca vulgaris and herpes zoster, described compound injection is by following
The bulk drug of weight portion is made: poly IC 0.2-2 part, Radix Isatidis 20-40 part, folium isatidis 20-40 part, perfume (or spice)
Attached 20-40 part, scouring rush's 20-40 part, Commelina communis 20-40 part.
Preferably, described compound injection is made up of the bulk drug of following weight portion: poly IC 0.5-1 part,
Radix Isatidis 25-35 part, folium isatidis 25-35 part, rhizoma cyperi 25-35 part, scouring rush's 25-35 part, Commelina communis 25-35
Part.
More preferably, described compound injection is made up of the bulk drug of following weight portion: poly IC 0.5 part, plate
Blue root 30 parts, folium isatidis 30 parts, rhizoma cyperi 30 parts, scouring rush 30 parts, Commelina communis 30 parts.
For realizing above-mentioned second purpose, the present invention adopts the technical scheme that:
The as mentioned above preparation method of the compound Polyinosinic injection for the treatment of verruca vulgaris and herpes zoster, comprise as
Lower step:
1) weigh Radix Isatidis, folium isatidis, rhizoma cyperi, scouring rush, Commelina communis by weight, clean, add for the first time
The boiling water water of 30 times carries 3h, and second time adds the boiling water water of 20 times and carries 2h, filters, and merging filtrate, filtrate exists
Being condensed into density under 60 DEG C of environment is 1.08-1.10g/cm3Concentrate；
2) poly IC is weighed by weight, by poly IC and step 1) concentrate for preparing mixes.
For realizing above-mentioned 3rd purpose, the present invention adopts the technical scheme that:
Arbitrary described compound Polyinosinic injection is in preparation treatment verruca vulgaris and shingles medications
Application.
For realizing above-mentioned 4th purpose, the present invention adopts the technical scheme that:
A kind of pharmaceutical composition treating verruca vulgaris and herpes zoster, including: arbitrary described compound gathers
Flesh born of the same parents' parenteral solution and pharmaceutically acceptable excipient；Described excipient is selected from: adhesive, filler,
One or more in film-coating polymer, plasticizer, glidant, disintegrant or lubricant.
For realizing above-mentioned 4th purpose, the present invention adopts the technical scheme that:
A kind of compound poly IC syringe treating verruca vulgaris and herpes zoster, lives including plastic bottle body, pressing
Plug, is provided with a bottle chamber in described plastic bottle body, bottle chamber is injected built with the compound poly IC described in claim 3
Liquid, described plastic bottle body side is provided with the button being connected with plastic bottle body, and the lower end of described plastic bottle body is provided with
The injection port connected with bottle chamber, injection port is provided with injection needles head, and plastic bottle body is additionally provided with block.
The invention has the advantages that:
1, instant effect, definite effect, raw material is extensive, with low cost；
2, injection needles head can replace use every time, it is to avoid pollutes；
3, the compound poly IC syringe of the present invention is easy to use, patient can voluntarily injection for curing verruca vulgaris,
Herpes zoster.
Accompanying drawing explanation
Accompanying drawing 1 treats the compound poly IC syringe construction schematic diagram of verruca vulgaris and herpes zoster for the present invention.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is expanded on further.Should be understood that these embodiments are only used for
The present invention is described rather than limits the scope of the present invention.In addition, it is to be understood that reading what the present invention recorded
After content, the present invention can be made various changes or modifications by those skilled in the art, and these equivalent form of values are same
Sample falls within the application appended claims limited range.
The preparation (one) of embodiment 1 compound Polyinosinic injection
Weigh poly IC 0.5 part, Radix Isatidis 30 parts, folium isatidis 30 parts, rhizoma cyperi 30 parts, wood by weight
Thief 30 parts, Commelina communis 30 parts, in medicinal water extract, the boiling water water adding for the first time 30 times carries 3h,
Second time adds the boiling water water of 20 times and carries 2h, filters, and merging filtrate, filtrate is condensed into close under 60 DEG C of environment
Degree is 1.08-1.10g/cm3Concentrate.Poly IC is mixed with the concentrate prepared.
The preparation (two) of embodiment 2 compound Polyinosinic injection
Weigh poly IC 0.2 part, Radix Isatidis 20 parts, folium isatidis 20 parts, rhizoma cyperi 20 parts, wood by weight
Thief 20 parts, Commelina communis 20 parts, in medicinal water extract, the boiling water water adding for the first time 30 times carries 3h,
Second time adds the boiling water water of 20 times and carries 2h, filters, and merging filtrate, filtrate is condensed into close under 60 DEG C of environment
Degree is 1.08-1.10g/cm3Concentrate.Poly IC is mixed with the concentrate prepared.
The preparation (three) of embodiment 3 compound Polyinosinic injection
Weigh poly IC 2 parts, Radix Isatidis 20 parts, folium isatidis 20 parts, rhizoma cyperi 20 parts, wood by weight
Thief 20 parts, Commelina communis 20 parts, in medicinal water extract, the boiling water water adding for the first time 30 times carries 3h,
Second time adds the boiling water water of 20 times and carries 2h, filters, and merging filtrate, filtrate is condensed into close under 60 DEG C of environment
Degree is 1.08-1.10g/cm3Concentrate.Poly IC is mixed with the concentrate prepared.
The preparation (four) of embodiment 4 compound Polyinosinic injection
Weigh poly IC 2 parts, Radix Isatidis 40 parts, folium isatidis 20 parts, rhizoma cyperi 20 parts, wood by weight
Thief 20 parts, Commelina communis 20 parts, in medicinal water extract, the boiling water water adding for the first time 30 times carries 3h,
Second time adds the boiling water water of 20 times and carries 2h, filters, and merging filtrate, filtrate is condensed into close under 60 DEG C of environment
Degree is 1.08-1.10g/cm3Concentrate.Poly IC is mixed with the concentrate prepared.
The preparation (five) of embodiment 5 compound Polyinosinic injection
Weigh poly IC 2 parts, Radix Isatidis 40 parts, folium isatidis 40 parts, rhizoma cyperi 20 parts, wood by weight
Thief 20 parts, Commelina communis 20 parts, in medicinal water extract, the boiling water water adding for the first time 30 times carries 3h,
Second time adds the boiling water water of 20 times and carries 2h, filters, and merging filtrate, filtrate is condensed into close under 60 DEG C of environment
Degree is 1.08-1.10g/cm3Concentrate.Poly IC is mixed with the concentrate prepared.
The preparation (six) of embodiment 6 compound Polyinosinic injection
Weigh poly IC 2 parts, Radix Isatidis 40 parts, folium isatidis 40 parts, rhizoma cyperi 40 parts, wood by weight
Thief 20 parts, Commelina communis 20 parts, in medicinal water extract, the boiling water water adding for the first time 30 times carries 3h,
Second time adds the boiling water water of 20 times and carries 2h, filters, and merging filtrate, filtrate is condensed into close under 60 DEG C of environment
Degree is 1.08-1.10g/cm3Concentrate.Poly IC is mixed with the concentrate prepared.
The preparation (seven) of embodiment 7 compound Polyinosinic injection
Weigh poly IC 2 parts, Radix Isatidis 40 parts, folium isatidis 40 parts, rhizoma cyperi 40 parts, wood by weight
Thief 40 parts, Commelina communis 20 parts, in medicinal water extract, the boiling water water adding for the first time 30 times carries 3h,
Second time adds the boiling water water of 20 times and carries 2h, filters, and merging filtrate, filtrate is condensed into close under 60 DEG C of environment
Degree is 1.08-1.10g/cm3Concentrate.Poly IC is mixed with the concentrate prepared.
The preparation (eight) of embodiment 8 compound Polyinosinic injection
Weigh poly IC 2 parts, Radix Isatidis 40 parts, folium isatidis 40 parts, rhizoma cyperi 40 parts, wood by weight
Thief 40 parts, Commelina communis 40 parts, in medicinal water extract, the boiling water water adding for the first time 30 times carries 3h,
Second time adds the boiling water water of 20 times and carries 2h, filters, and merging filtrate, filtrate is condensed into close under 60 DEG C of environment
Degree is 1.08-1.10g/cm3Concentrate.Poly IC is mixed with the concentrate prepared.
The preparation (nine) of embodiment 9 compound Polyinosinic injection
Weigh poly IC 0.5 part, Radix Isatidis 25 parts, folium isatidis 25 parts, rhizoma cyperi 25 parts, wood by weight
Thief 25 parts, Commelina communis 25 parts, in medicinal water extract, the boiling water water adding for the first time 30 times carries 3h,
Second time adds the boiling water water of 20 times and carries 2h, filters, and merging filtrate, filtrate is condensed into close under 60 DEG C of environment
Degree is 1.08-1.10g/cm3Concentrate.Poly IC is mixed with the concentrate prepared.
The preparation (ten) of embodiment 10 compound Polyinosinic injection
Weigh poly IC 1 part, Radix Isatidis 35 parts, folium isatidis 35 parts, rhizoma cyperi 35 parts, wood by weight
Thief 35 parts, Commelina communis 35 parts, in medicinal water extract, the boiling water water adding for the first time 30 times carries 3h,
Second time adds the boiling water water of 20 times and carries 2h, filters, and merging filtrate, filtrate is condensed into close under 60 DEG C of environment
Degree is 1.08-1.10g/cm3Concentrate.Poly IC is mixed with the concentrate prepared.
Embodiment 11 treats verruca vulgaris clinical data
1 physical data
Choose the court's Dermatology Outpatient Department patient 150 example, women 76 example, the male sex 74 example, minimum 21 years old of age,
Big 63 years old, disease time was many in 1-5,41.5 years old mean age.
2 diagnostic criteria
2.1 " the disease of tcm Standardization of diagnosis and curative effects " issued and implemented with reference to State Administration of Traditional Chinese Medicine.
1, skin damages as Peas big, rounded or polygonal, and rough surface exceeds surface, and that touches is hard solid, in
Sallow, dirty yellow or dirty brown, finally breed in nipple sample；
2, it is more common in teenager, is apt to occur in finger, the back of the hand, foot edge etc.；
3, the course of disease is chronic, collides, rubs the most hemorrhage, often has tenderness；
4, tissue pathology checking, the obvious angling in surface and acanthosis, epidermis top cavity is formed in netted,
Papillomatous hyperplasia.
2.2 inclusive criterias:
1, diagnostic criteria is met；
2, treatment and regular further consultation observer are accepted voluntarily；
3, in three months, non-system used immunomodulator person；
4, signature Informed Consent Form.
2.3 exclusion standard
1, the wart patient of other type such as flat wart and condyloma acuminatum it is diagnosed as；
2, verrucoid nevus patient；
3, therapeutic process is arbitrarily changed methods for the treatment of or medicine person；
4, gestation or women breast-feeding their children；
5, scar diathesis patient；
6, can not as scheduled further consultation with accept tester.
3, methods for the treatment of
Treatment group one: use the compound Polyinosinic injection of the embodiment of the present invention 1 preparation；
Treatment group two: use the compound Polyinosinic injection of the embodiment of the present invention 2 preparation；
Treatment group three: use the compound Polyinosinic injection of the embodiment of the present invention 10 preparation；
Control group one: use liquid prepared by following medicine: poly IC 0.5 part, Radix Isatidis 30 parts, folium isatidis
30 parts, rhizoma cyperi 30 parts, scouring rush 30 parts, in medicinal water extract, the boiling water water adding for the first time 30 times carries 3h,
Second time adds the boiling water water of 20 times and carries 2h, filters, and merging filtrate, filtrate is condensed into density under 60 DEG C of environment
For 1.08-1.10g/cm3Concentrate.Poly IC is mixed with the concentrate prepared；
Control group two: use Polyinosinic injection.
Using method: to wart body surrounding skin routine disinfection, extract parenteral solution 2ml with syringe, by wart body
Inject wart body basal part at 3mm, maximum wart body only need to be injected by many originator.Injection 2 times weekly,
Observe lesions of patients situation and make clerking, after treating 4 weeks, evaluating curative effect, after 12 weeks, follow up a case by regular visits to recurrence.
4 treatment results
4.1 clinical efficacy evaluation criteria
With reference to " the disease of tcm Standardization of diagnosis and curative effect " of State Administration of Traditional Chinese Medicine's issuing and implementation,
Recovery from illness: wart body all disappears, and flattens at disease damage, occurs without new fash；
Effective: wart body disappears > 70%, retain operative tip and flatten；
Take a turn for the better: wart body disappears 30%, skin damages a substrate and does not reduces；
Invalid: wart body disappear < 30%, unchanged or have new wart body to occur；
Recurrence: at former position or other positions, new wart body occurs in 3 months；
Total effective rate=(the recovery from illness effective number of cases of number of cases ten) total number of cases/100% of *.
4.2 result
After treating 4 weeks, add up each group of result, be shown in Table 1.
Table 1 is each group comparitive study example (%) after treating 4 weeks
| Group | Number of cases | Recovery from illness | Effective | Take a turn for the better | Invalid | Total effective rate |
| Treatment group one | 30 | 23(76.7) | 4(13.3) | 2(6.6) | 1(3.3) | 27(90.0) |
| Treatment group two | 30 | 18(60.0) | 6(20) | 3(10) | 3(10) | 24(80.0) |
| Treatment group three | 30 | 17(56.7) | 6(20) | 3(10) | 4(13.3) | 23(76.7) |
| Control group one | 30 | 12(40) | 10(33.3) | 4(13.3) | 4(13.3) | 22(73.3) |
| Control group two | 30 | 10(33.3) | 7(23.3) | 4(13.3) | 9(30.0) | 17(56.7) |
As seen from the above table, it is 76.7% that treatment group one of the present invention treats verruca vulgaris cure rate, and total effective rate is
90.0%；The obvious effective rate for the treatment of group one is significantly higher than other treatment group.
After 12 weeks, five groups of Follow-up results are shown in Table 2.
Table 2 is respectively organized Follow-up results after treating 12 weeks and is compared
| Group | Follow up a case by regular visits to number of cases | Depigmentation case | Recurrence | Do not recur | Recurrence rate |
| Treatment group one | 30 | 0 | 0 | 30 | 0※# |
| Treatment group two | 30 | 1 | 1 | 29 | 3.3% ※ # |
| Treatment group three | 30 | 1 | 1 | 29 | 3.3% ※ # |
| Control group one | 30 | 0 | 5 | 25 | 16.7% |
| Control group two | 30 | 0 | 10 | 20 | 23.3% |
Note: compare ※ P < 0.05 with control group one；#P < 0.05 is compared with control group two
The recurrence rate following up a case by regular visits to five groups after 12 weeks compares, from Table 2, it can be seen that treatment group one, treatment group two and
After treatment group three treatment, recurrence rate is less than control group, illustrates that the liquid of the present invention more can effectively control conventional wart
Recurrence.
Embodiment 12 treats herpes zoster clinical observation
1 physical data
Choose the 80 example Patients with Herpes Zosters that the court accepts for medical treatment.The maleest 39 examples, female 51 example, age 22-72 year.
2 diagnostic criteria
Meet the examining of herpes zoster in " the Chinese medical disease Standardization of diagnosis and curative effect " that State Administration of Traditional Chinese Medicine issues
Disconnected standard.
1) skin damages the water scar mostly being mung bean or soya bean size, assembles at one or many places in threes and fours, is arranged in band
Shape, substrate flush, even serious time may occur in which that blutpunkte, blood scar are downright bad；
2) from the beginning of rubefaction, and accompany skin irritation or burning heat sensation, can with grade fever, tired discomfort,
The constitutional symptoms such as poor appetite.Conscious pain is obvious, has severe pain unbearably and postherpetic neuralgia symptom.
3 methods of treatments
Use the compound Polyinosinic injection of the embodiment of the present invention 1 preparation, in bleb local routine disinfection, with 5
Milliliter syringe parenteral solution parenteral solution 2ml, is subcutaneously injected by around bleb, and inserting needle limit, limit pushes away medicine.Such as fruit disease
Stove is relatively big, can increase injection point in right amount in inside, make liquid be homogenously dispersed focus subcutaneous, every day 1 time.
4 criterions of therapeutical effect
Recovery from illness: deflorescence, clinical symptom disappearance, without pain sequelae；
Take a turn for the better: deflorescence about 50%, pain substantially alleviates；
Do not heal: deflorescence, less than 30%, still has pain malaise symptoms.
5 results
All cases was all fully recovered in 4-10 days, and wherein recovery from illness patient 53 example in 3-5 days, accounts for 66.3%；6-8 days
Interior recovery from illness patient 18, accounts for 22.5%；In 9-10 days, recovery from illness patient 8 example, accounts for 10%.
The compound poly IC syringe of embodiment 13 present invention
Refer to Fig. 1, Fig. 1 is the compound poly IC syringe construction that the present invention treats verruca vulgaris and herpes zoster
Schematic diagram.Its structure includes plastic bottle body 1, pressing piston 2, is provided with bottle chamber 3, bottle in described plastic bottle body 1
The compound Polyinosinic injection that chamber 3 is prepared built with embodiment 1, is provided with in the side of described plastic bottle body 1 and moulds
The button 4 that material bottle 1 connects, the lower end of described plastic bottle body 1 is provided with the injection port 5 connected with bottle chamber 3, injection
Mouth 5 is provided with injection needles head 6.Block also can be provided with on described plastic bottle body 1.
The capacity in bottle chamber 3 has 3 kinds of specifications, is 5ml, 15ml, 35ml respectively, and injection needles head 6 is each
After using detachably, new syringe needle is replaced, it is to avoid pollute.Verruca vulgaris and Patients with Herpes Zoster use the present invention
Compound poly IC syringe can under the guidance of doctor injection for curing voluntarily, using method is as follows: take off
Block, installs and plugs injection needles head, syringe needle is directed at injection site (skin site of disease), uses thumb
Pressing button 4, button 4 extrudes the bottle chamber 3 in plastic bottle body 1, and the square Polyinosinic injection in bottle chamber 3 injects pin
Head also injects patient illness part, unclamps the most rapidly thumb, makes needle retractable, injects complete, pull up pin
Head, covers cover.
The above is only the preferred embodiment of the present invention, it is noted that common for the art
Technical staff, on the premise of without departing from the inventive method, it is also possible to makes some improvement and supplements, these
Improve and supplement and also should be regarded as protection scope of the present invention.
Claims (7)
1. the compound Polyinosinic injection treating verruca vulgaris and herpes zoster, it is characterised in that: described compound
Parenteral solution is made up of the bulk drug of following weight portion: poly IC 0.2-2 part, Radix Isatidis 20-40 part, folium isatidis
20-40 part, rhizoma cyperi 20-40 part, scouring rush's 20-40 part, Commelina communis 20-40 part.
Treatment verruca vulgaris the most according to claim 1 and the compound Polyinosinic injection of herpes zoster, it is special
Levy and be: described compound injection is made up of the bulk drug of following weight portion: poly IC 0.5-1 part, Radix Isatidis
25-35 part, folium isatidis 25-35 part, rhizoma cyperi 25-35 part, scouring rush's 25-35 part, Commelina communis 25-35 part.
Treatment verruca vulgaris the most according to claim 1 and the compound Polyinosinic injection of herpes zoster, it is special
Levy and be: described compound injection is made up of the bulk drug of following weight portion: poly IC 0.5 part, Radix Isatidis
30 parts, folium isatidis 30 parts, rhizoma cyperi 30 parts, scouring rush 30 parts, Commelina communis 30 parts.
4. the system of the compound Polyinosinic injection of the arbitrary described treatment verruca vulgaris of claim 1-3 and herpes zoster
Preparation Method, it is characterised in that: comprise the steps of:
1) weigh Radix Isatidis, folium isatidis, rhizoma cyperi, scouring rush, Commelina communis by weight, clean, add for the first time
The boiling water water of 30 times carries 3h, and second time adds the boiling water water of 20 times and carries 2h, filters, and merging filtrate, filtrate exists
Being condensed into density under 60 DEG C of environment is 1.08-1.10g/cm3Concentrate；
2) poly IC is weighed by weight, by poly IC and step 1) concentrate for preparing mixes.
5. the arbitrary described compound Polyinosinic injection of claim 1-3 is at preparation treatment verruca vulgaris and herpes zoster
Application in medicine.
6. the pharmaceutical composition treating verruca vulgaris and herpes zoster, it is characterised in that: including: claim
The arbitrary described compound Polyinosinic injection of 1-3 and pharmaceutically acceptable excipient；Described excipient choosing
From: the one in adhesive, filler, film-coating polymer, plasticizer, glidant, disintegrant or lubricant
Or it is multiple.
7. treat a compound poly IC syringe for verruca vulgaris and herpes zoster, live including plastic bottle body, pressing
Plug, it is characterised in that: being provided with a bottle chamber in described plastic bottle body, bottle chamber is built with answering described in claim 3
Side's Polyinosinic injection, described plastic bottle body side is provided with the button being connected with plastic bottle body, described plastic bottle
The lower end of body is provided with the injection port connected with bottle chamber, and injection port is provided with injection needles head, plastic bottle body
On be additionally provided with block.
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