CN101461938A - Preparation for treating flat wart and preparation method thereof - Google Patents
Preparation for treating flat wart and preparation method thereof Download PDFInfo
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- CN101461938A CN101461938A CNA2008102498961A CN200810249896A CN101461938A CN 101461938 A CN101461938 A CN 101461938A CN A2008102498961 A CNA2008102498961 A CN A2008102498961A CN 200810249896 A CN200810249896 A CN 200810249896A CN 101461938 A CN101461938 A CN 101461938A
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Abstract
The invention discloses a reagent for treating flat wart and a method for preparing the same. The reagent consists of the following drug-effect raw materials by weight: 2 to 50g of Nutgrass Galingale Rhizome, 1 to 30g of common scouring rush herb, 1 to 100g of Rhizoma Zedoariae, 1 to 50g of isatis leaf, 1 to 50g of isatis root, 1.5*10<7> to 2.0*10<7>U of alpha-2b interferon, 1 to 20g of sodium cellulose glycolate, 2 to 50g of glycerin, and 0.05 to 0.2g of ethyl p-hydroxybenzaote. By the combination of the traditional Chinese medicine principle and the alpha-2b interferon antivirus concept, the invention develops the reagent for treating the flat wart, which consists of the alpha-2b interferon and external-use anti-virus compositions, and the reagent has broad-spectrum antivirus activity and immunity adjusting function; and in the clinical treatment, the average effect-starting time is shorter than that of the 5 percent imiquimod cream; moreover, the reagent also has the advantages of stability, reliability, no pungency, strong inhibition on HSV, no uncomfortable feeling after application, simple preparation method and low cost.
Description
Technical field
The present invention relates to pharmaceutical sanitary field, especially a kind of preparation for the treatment of verruca plana and preparation method thereof.
Background technology
Verruca plana is a kind of good sending out in the flat pimple of teenager face, the back of the hand and forearm, is the colour of skin, pale red or brown, influences attractive in appearance.At present, its Therapeutic Method is a lot, but differs for generalized verruca plana's curative effect.Verruca plana is due to the human parillomarvirus infections epidermis, and the course of disease is slower, and is how relevant with immunologic hypofunction.Its virus replication height depends on the differentiation of keratinocyte.Studies show that the obvious hyperkeratosis of verruca plana epidermis, acanthosis, the granular layer uniform thickened, the cuticular layer cell is tangible basket shape because of cavity forms.
The external curing method of verruca plana is a lot, and it is anxious that external tretinoin or 5-FU spot printing, general property patient Chang Yin are cured the disease, smear in a large number easily to cause and smear the red and swollen excitation in position, even produce temporary pigmentation spots, and require the patient that compliance is preferably arranged, generally should not use the verruca plana of facial area.More in recent years report external immunomodulator treatment face flat wart.Cai Changbin adopts 5% imiquimod cream exterior coating treatment verruca plana to obtain satisfactory effect.
Summary of the invention
Purpose of the present invention promptly is to provide a kind of preparation for the treatment of verruca plana and preparation method thereof at the deficiency of above-mentioned prior art existence, use herbal mixture associating α-2b interferon gelatin treatment face flat wart, both synergism are good, satisfactory effect, untoward reaction is little, obviously is better than simple external-applied interferon gel.
For achieving the above object, technical scheme of the present invention is as follows:
A kind of preparation for the treatment of verruca plana is made up of the following pharmacodynamic raw material: Rhizoma Cyperi 2-50g, Herba Equiseti Hiemalis 1-30g, Rhizoma Curcumae 1-100g, Folium Isatidis 1-50g, Radix Isatidis 1-50g, α-2b interferon 1.5*10
7-2.0*10
7U, sodium carboxymethyl cellulose 1-20g, glycerol 2-50g, ethylparaben 0.05-0.2g.
A kind of preparation for the treatment of verruca plana is made up of the following pharmacodynamic raw material: Rhizoma Cyperi 10g, Herba Equiseti Hiemalis 5g, Rhizoma Curcumae 10g, Folium Isatidis 6g, Radix Isatidis 6g, α-2b interferon 1.8*10
7U, sodium carboxymethyl cellulose 4g, glycerol 16g, ethylparaben 0.1g.
A kind of preparation method for the treatment of the preparation of verruca plana, get the pharmacodynamic raw materials of above-mentioned weight proportion respectively, at first Rhizoma Cyperi, Herba Equiseti Hiemalis, Rhizoma Curcumae, Folium Isatidis, Radix Isatidis are put into container and add water 100-1000ml, boil 10-60min after soaking 15-30min, filtering extracting liquid is concentrated into 50-200ml, it is evenly mixed to add sodium carboxymethyl cellulose, glycerol, ethylparaben again, autoclaving 20-40min under 100-120 ℃ of situation, naturally cool to room temperature, add α-2b interferon solution, slowly stir into gel, be sub-packed in the medicinal aluminum pipe.
A kind of preparation method for the treatment of the preparation of verruca plana, get the pharmacodynamic raw materials of above-mentioned weight proportion respectively, at first Rhizoma Cyperi, Herba Equiseti Hiemalis, Rhizoma Curcumae, Folium Isatidis, Radix Isatidis are put into container and add water 200ml, boil 30min after soaking 20min, filtering extracting liquid is concentrated into 90ml, it is evenly mixed to add sodium carboxymethyl cellulose, glycerol, ethylparaben again, autoclaving 30min under 115 ℃ of situations, naturally cool to room temperature, add α-2b interferon solution, slowly stir into gel, be sub-packed in the medicinal aluminum pipe.
The pharmacology curative effect of above-mentioned raw material of Chinese medicine is as follows:
Rhizoma Cyperi: gas is flat, and the little hardship of acrid in the mouth is little sweet.Go into liver, tri-jiao channel.The resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.
The Herba Equiseti Hiemalis: sweet in the mouth, hardship, property is flat.Return lung, Liver Channel.Dispelling wind and heat pathogens, improving acuity of vision and removing nebula.
Rhizoma Curcumae: acrid in the mouth, hardship, warm in nature.Return liver, spleen channel.The circulation of qi promoting removing blood stasis, the removing food stagnancy pain relieving.
Folium Isatidis: gas is cold, and mildly bitter flavor is salty.GUIXIN, stomach warp.Heat clearing away, detoxifcation, removing heat from blood, hemostasis.
Radix Isatidis: hardship, cold, nontoxic.Go into liver, stomach blood system.Heat clearing away, detoxifcation, removing heat from blood.
The effect of other three kinds of additive sodium carboxymethyl cellulose, glycerol and ethylparabens is as follows:
Effects such as that sodium carboxymethyl cellulose has is bonding, suspending, thickening, emulsifying, slow release with being suspending agent, thickening agent, emulsifying agent, are made gel-type vehicle in semi-solid preparation in liquid preparation, make binding agent, disintegrating agent and slow-release auxiliary material in tablet.
Glycerol is colourless viscous liquid, and odorlessness has warm sweet taste, can the moisture absorption.Be used for gas chromatogram fixative and organic synthesis, also can be used as solvent, tolerance and take into account hydraulic press shock absorber fluid, softening agent, antibiotic fermentation with nutrient, desiccant etc.
Ethylparaben is stronger to the fungistatic effect of fungus, but to the fungistatic effect of antibacterial a little less than.As antibacterial antiseptic, be widely used in liquid preparation and semi-solid preparation, also can be used for the anticorrosion of food and cosmetics.
So above three kinds of raw material effects in the present invention are that Chinese medicine of the five flavours raw material such as Rhizoma Cyperi, Herba Equiseti Hiemalis and α-2b interferon are made into gel through after a series of processing.
The traditional Chinese medical science thinks that verruca plana is in the damp and hot pent-up of spleen lung, and the fire stagnation skin is to fight and give birth in skin owing to ailment said due to cold or exposure poison, control with the dampness heat clearing away, the softening the hard mass blood stasis dispelling, antiviral, the formula combination of the Chinese medicine Rhizoma Cyperi among the present invention, Herba Equiseti Hiemalis, Rhizoma Curcumae, Folium Isatidis, Radix Isatidis can reach above-mentioned effect.
Interferon is one group of reactive protein (mainly being glycoprotein) with multiple function, is a kind of cytokine that is produced by mononuclear cell and lymphocyte.They have the broad-spectrum antiviral on allogenic cell, influence the cell growth, and differentiation, regulate multiple biological activity such as immunologic function.
The present invention promptly is in conjunction with theory of Chinese medical science and α-2b interferon anti-reflecting virus notion and develop a kind of preparation for the treatment of verruca plana, combine by α-2b interferon and external Chinese medicine antiviral ingredients, effect of broad-spectrum antiviral activity and immunoloregulation function are arranged, in treatment clinical course its average onset time shorter than 5% imiquimod cream, reliable and stable, nonirritant, strong to the HSV inhibitory action, smear the no sense of discomfort in back, preparation method is simple, and is with low cost.
The specific embodiment
Describe the present invention below in conjunction with specific embodiment:
Embodiment 1:
Get Rhizoma Cyperi 2g, Herba Equiseti Hiemalis 30g, Rhizoma Curcumae 1g, Folium Isatidis 50g, Radix Isatidis 1g, α-2b interferon alpha-2 .0*10 respectively
7U, sodium carboxymethyl cellulose 1g, glycerol 50g, ethylparaben 0.05g, at first Rhizoma Cyperi, Herba Equiseti Hiemalis, Rhizoma Curcumae, Folium Isatidis, Radix Isatidis are put into container and add water 100ml, boil 10min after soaking 30min, filtering extracting liquid is concentrated into 50ml, it is evenly mixed to add sodium carboxymethyl cellulose, glycerol, ethylparaben again, autoclaving 40min under 100 ℃ of situations, naturally cool to room temperature, add α-2b interferon solution, slowly stir into gel, be sub-packed in the medicinal aluminum pipe, every is 12g.
Embodiment 2:
Get Rhizoma Cyperi 5g, Herba Equiseti Hiemalis 18g, Rhizoma Curcumae 6g, Folium Isatidis 40g, Radix Isatidis 10g, α-2b interferon 1.7*10 respectively
7U, sodium carboxymethyl cellulose 6g, glycerol 10g, ethylparaben 0.07g, at first Rhizoma Cyperi, Herba Equiseti Hiemalis, Rhizoma Curcumae, Folium Isatidis, Radix Isatidis are put into container and add water 150ml, boil 20min after soaking 25min, filtering extracting liquid is concentrated into 80ml, it is evenly mixed to add sodium carboxymethyl cellulose, glycerol, ethylparaben again, autoclaving 35min under 105 ℃ of situations, naturally cool to room temperature, add α-2b interferon solution, slowly stir into gel, be sub-packed in the medicinal aluminum pipe, every is 12g.
Embodiment 3:
Get Rhizoma Cyperi 10g, Herba Equiseti Hiemalis 5g, Rhizoma Curcumae 10g, Folium Isatidis 6g, Radix Isatidis 6g, α-2b interferon 1.8*10 respectively
7U, sodium carboxymethyl cellulose 4g, glycerol 16g, ethylparaben 0.1g.At first Rhizoma Cyperi, Herba Equiseti Hiemalis, Rhizoma Curcumae, Folium Isatidis, Radix Isatidis are put into container and add water 200ml, boil 30min after soaking 20min, filtering extracting liquid is concentrated into 90ml, it is evenly mixed to add sodium carboxymethyl cellulose, glycerol, ethylparaben again, and autoclaving 30min under 115 ℃ of situations naturally cools to room temperature, add α-2b interferon solution, slowly stir into gel, be sub-packed in the medicinal aluminum pipe, every is 12g.
Embodiment 4:
Get Rhizoma Cyperi 25g, Herba Equiseti Hiemalis 15g, Rhizoma Curcumae 50g, Folium Isatidis 25g, Radix Isatidis 25g, α-2b interferon 1.6*10 respectively
7U, sodium carboxymethyl cellulose 10g, glycerol 26g, ethylparaben 0.18g, at first Rhizoma Cyperi, Herba Equiseti Hiemalis, Rhizoma Curcumae, Folium Isatidis, Radix Isatidis are put into container and add water 500ml, boil 40min after soaking 22min, filtering extracting liquid is concentrated into 120ml, it is evenly mixed to add sodium carboxymethyl cellulose, glycerol, ethylparaben again, autoclaving 25min under 110 ℃ of situations, naturally cool to room temperature, add α-2b interferon solution, slowly stir into gel, be sub-packed in the medicinal aluminum pipe, every is 12g.
Embodiment 5:
Get Rhizoma Cyperi 40g, Herba Equiseti Hiemalis 25g, Rhizoma Curcumae 70g, Folium Isatidis 15g, Radix Isatidis 35g, α-2b interferon 1.8*10 respectively
7U, sodium carboxymethyl cellulose 15g, glycerol 35g, ethylparaben 0.12g, at first Rhizoma Cyperi, Herba Equiseti Hiemalis, Rhizoma Curcumae, Folium Isatidis, Radix Isatidis are put into container and add water 800ml, boil 50min after soaking 18min, filtering extracting liquid is concentrated into 150ml, it is evenly mixed to add sodium carboxymethyl cellulose, glycerol, ethylparaben again, autoclaving 28min under 118 ℃ of situations, naturally cool to room temperature, add α-2b interferon solution, slowly stir into gel, be sub-packed in the medicinal aluminum pipe, every is 12g.
Embodiment 6:
Get Rhizoma Cyperi 50g, Herba Equiseti Hiemalis 1g, Rhizoma Curcumae 100g, Folium Isatidis 1g, Radix Isatidis 50g, α-2b interferon 1.5*10 respectively
7U, sodium carboxymethyl cellulose 20g, glycerol 2g, ethylparaben 0.2g, at first Rhizoma Cyperi, Herba Equiseti Hiemalis, Rhizoma Curcumae, Folium Isatidis, Radix Isatidis are put into container and add water 1000ml, boil 60min after soaking 15min, filtering extracting liquid is concentrated into 200ml, it is evenly mixed to add sodium carboxymethyl cellulose, glycerol, ethylparaben again, autoclaving 20min under 120 ℃ of situations, naturally cool to room temperature, add α-2b interferon solution, slowly stir into gel, be sub-packed in the medicinal aluminum pipe, every is 12g.
Claims (4)
1, a kind of preparation for the treatment of verruca plana is characterized in that, is made up of the following pharmacodynamic raw material: Rhizoma Cyperi 2-50g, Herba Equiseti Hiemalis 1-30g, Rhizoma Curcumae 1-100g, Folium Isatidis 1-50g, Radix Isatidis 1-50g, α-2b interferon 1.5*10
7-2.0*10
7U, sodium carboxymethyl cellulose 1-20g, glycerol 2-50g, ethylparaben 0.05-0.2g.
2, the preparation of treatment verruca plana according to claim 1 is characterized in that, is made up of the following pharmacodynamic raw material: Rhizoma Cyperi 10g, Herba Equiseti Hiemalis 5g, Rhizoma Curcumae 10g, Folium Isatidis 6g, Radix Isatidis 6g, α-2b interferon 1.8*10
7U, sodium carboxymethyl cellulose 4g, glycerol 16g, ethylparaben 0.1g.
3, the preparation method of the preparation of treatment verruca plana as claimed in claim 1, it is characterized in that, get the pharmacodynamic raw materials of above-mentioned weight proportion respectively, at first with Rhizoma Cyperi, the Herba Equiseti Hiemalis, Rhizoma Curcumae, Folium Isatidis, Radix Isatidis is put into container and is added water 100-1000ml, boil 10-60min after soaking 15-30min, filtering extracting liquid is concentrated into 50-200ml, add sodium carboxymethyl cellulose again, glycerol, ethylparaben is evenly mixed, autoclaving 20-40min under 100-120 ℃ of situation, naturally cool to room temperature, add α-2b interferon solution, slowly stir into gel, be sub-packed in the medicinal aluminum pipe.
4, the preparation method of the preparation of treatment verruca plana as claimed in claim 1, it is characterized in that, get the pharmacodynamic raw materials of above-mentioned weight proportion respectively, at first Rhizoma Cyperi, Herba Equiseti Hiemalis, Rhizoma Curcumae, Folium Isatidis, Radix Isatidis are put into container and add water 200ml, boil 30min after soaking 20min, filtering extracting liquid is concentrated into 90ml, it is evenly mixed to add sodium carboxymethyl cellulose, glycerol, ethylparaben again, autoclaving 30min under 115 ℃ of situations, naturally cool to room temperature, add α-2b interferon solution, slowly stir into gel, be sub-packed in the medicinal aluminum pipe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008102498961A CN101461938A (en) | 2008-12-31 | 2008-12-31 | Preparation for treating flat wart and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008102498961A CN101461938A (en) | 2008-12-31 | 2008-12-31 | Preparation for treating flat wart and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101461938A true CN101461938A (en) | 2009-06-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2008102498961A Pending CN101461938A (en) | 2008-12-31 | 2008-12-31 | Preparation for treating flat wart and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770290A (en) * | 2016-03-08 | 2016-07-20 | 上海中医药大学附属岳阳中西医结合医院 | Compound polyinosinic cell injection for treating verruca vulgaris and herpes zoster and application thereof |
| CN108421003A (en) * | 2018-05-30 | 2018-08-21 | 武汉润禾生物医药有限公司 | A kind of antibacterial ointment and preparation method thereof for treating flat wart |
-
2008
- 2008-12-31 CN CNA2008102498961A patent/CN101461938A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770290A (en) * | 2016-03-08 | 2016-07-20 | 上海中医药大学附属岳阳中西医结合医院 | Compound polyinosinic cell injection for treating verruca vulgaris and herpes zoster and application thereof |
| CN108421003A (en) * | 2018-05-30 | 2018-08-21 | 武汉润禾生物医药有限公司 | A kind of antibacterial ointment and preparation method thereof for treating flat wart |
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Open date: 20090624 |