CN101352486A - Isatis root and astragalus microspheres for injections and preparation method thereof - Google Patents
Isatis root and astragalus microspheres for injections and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a radix isatidis and radix astragali microsphere for injection and a preparation method thereof; the radix isatidis and radix astragali microsphere for injection consists of 5-65% of Chinese medicinal material extracts which are taken as active ingredients and 35-90 % of biodegradable medicinal high-molecular excipients which have microsphere weight and molecular weight ranging from 4,000 to 9,000,000 by weight percentage, wherein, the weight percentage of medicinal materials is as follows: 15%-50% of radix isatidis, 8%-20% of liquorice, 12%-40 % of hypericum perforatum and 15%-50% of radix astragali. The medicines are prepared into microspheres by the emulsion and dispersion method. The invention has the advantages of: (1) developing a new medicine for preventing and treating poultry viral diseases and improving disease resistance of the body for clinical application; (2) reasonable prescription and strong antiviral ability; (3) advanced technique, stable preparation and long storage time; (4) broad medicine sources, no toxic and side effect, little drug resistance generated and meeting the international sanitary inspection requirements. Especially, the radix isatidis and radix astragali microsphere for injection has significant effect on the treatment of poultry infectious bursal disease, untypical Newcastle disease, infective bronchitis, etc.
Description
Technical field
The present invention relates to treat the field of medicaments of Animal diseases, particularly a kind of effective isatis root and astragalus microspheres for injections and preparation method thereof.
Background technology
At present, usually based on antibiotic therapy, so not only toxic and side effects is bigger, as the hepatic and renal function to birds certain side effect is arranged, and easily causes the birds drug disposition residual aspect the treatment avian viral diseases; Simultaneously also with environmental pollution, and medical expense is higher.
The Radix Astragali is the dry root of leguminous plant Radix Astagali or Radix Astragali.Its Main Ingredients and Appearance is Russia's class, polysaccharide, aminoacid and trace element.Have enhancing human body immunity power, diuresis, defying age, protect the liver, effect such as blood pressure lowering, heart tonifying, expansion coronary vasodilator and whole body peripheral vessel, anti-mattress, be one of Chinese medicine of using always.
Motherland's medical science thinks that the Radix Astragali both can be used as medicine separately, also can unite use with other medical material, to reach clinical required curative effect.Isatis root and astragalus is a kind of Chinese medicine preparation, and Main Ingredients and Appearance is Radix Glycyrrhizae, the Radix Astragali, Radix Isatidis, Herba Hyperici perforati.The Radix Isatidis heat-clearing and toxic substances removing, removing heat from blood, sore-throat relieving, detumescence.Radix Glycyrrhizae is the pulse family perennial herb, and medicinal rhizome has the function of heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, spleen invigorating tonify deficiency, invigorating the spleen and replenishing QI; The Radix Astragali can invigorating QI to consolidate the body surface resistance, diuresis, and row is dense for poison holding, expelling pus and promoting granulation; Herba Hyperici perforati bitter in the mouth cool in nature, clearing heart fire goes the various heat symptom-complexs of the part of the body cavity above the diaphragm housing the heart and lungs, is applicable to epidemic febrile disease from the beginning of, headache, heating, excessive thirst, and the carbuncle skin ulcer that pyretic toxicity pent-up causes swells and ache, erysipelas, macule etc.
If adopt raw material of Chinese medicine to make tablet, powder etc., because the interior half-life of the Chinese crude drug water-soluble active ingredient body that has is shorter, need frequent drug administration, therefore use inconvenience; Assimilation effect is not good enough simultaneously, and therapeutic effect is not ideal enough.
Therefore, how providing that a kind of prevention effect is remarkable, the simple isatis root and astragalus microspheres for injections of technology and preparation method thereof, is one of this technical field scientific research personnel new problem of being badly in need of developing.
Summary of the invention
The object of the invention is to provide a kind of brand-new slow release, the isatis root and astragalus microspheres for injections of high bioavailability.
Another object of the present invention is to provide the preparation method of this isatis root and astragalus microspheres for injections.
The present invention is achieved through the following technical solutions:
A kind of isatis root and astragalus microspheres for injections, it is characterized in that comprising that 5～65% the extract by Chinese crude drug is that 35～90% molecular weight ranges of active component and microsphere weight is 4,000～9000, biodegradable medicinal high polymer adjuvant between 000 is formed, the composition of its Chinese crude drug % proportioning by weight is: Radix Isatidis 15%～50%, Radix Glycyrrhizae 8%～20%, Herba Hyperici perforati 12%～40%, the Radix Astragali 15%～50%.
The preferred weight percentage composition of described active component crude drug is: Radix Isatidis 30%, Radix Glycyrrhizae 10%, Herba Hyperici perforati 25%, the Radix Astragali 35%.
Described medicinal high polymer adjuvant is selected from polylactide-co-glycolide, polylactic acid, polyglycolic acid, poly--the 3-butyric ester, polylactic acid-polyglycolic acid, polylactic acid. glycolic, poly-adjacent ester, polylactone, polyanhydride, poly butyric ester-hydroxyl pentanoate copolymer, polyglycolic acid, polypropylene glucosan, hydroxyacetic acid, polylactic acid-polyglycol, polyglycolic acid. and Polyethylene Glycol one or more mixing wherein.
Excellent polylactide-co-glycolide, polylactic acid, the polylactic acid of being selected from of described medicinal high polymer adjuvant. one or more mixing wherein of polyglycolic acid, polylactic acid-glycollic acid, poly butyric ester-hydroxyl pentanoate copolymer.
Described medicinal high polymer adjuvant is a polylactide-co-glycolide; Its molecular weight of described polylactide-co-glycolide is between 9000～13000 dalton; Lactide and Acetic acid, hydroxy-, bimol. cyclic ester polymerization ratio are between 40: 60～60: 40 in the polylactide-co-glycolide.
The said medicine composition proportion by the weight % proportioning of use crude drug, be made into preparation need to described Radix Isatidis, Radix Glycyrrhizae, Herba Hyperici perforati, the Radix Astragali etc. further separately or mixed extraction be processed into extract and make gel film with suitable adjuvant.Extracting method wherein generally includes: water extraction method, decoction and alcohol sedimentation technique or microwave extraction method etc.For the ease of understanding, the existing extracting method in present technique field is described below for example:
Radix Isatidis microwave extraction method: after getting Radix Isatidis and pulverizing, the flask of setting fire, and this flask put in people's microwave reactor, alcohol reflux is adjusted microwave power and is extracted, and collects extracting solution, Radix Isatidis extract.
The liquorice beverage lifting manipulation: the extracting liquorice medical material, 20 mesh sieves are pulverized, twice of extracting in water, the water logging bubble that adds for the first time 9～10 times of amounts, heating extraction 1.5 hours adds 5～7 times of water gagings, heating extraction 1 hour for the second time, merge extractive liquid,, suitably concentrate, add 95% ethanol, make to contain alcohol amount arrival 50-70%, concentrate and reclaim ethanol, get Radix Glycyrrhizae extract.
The ethanol extraction method of Herba Hyperici perforati: get the Herba Hyperici perforati medical material, 20 mesh sieves are pulverized, and add the ethanol extraction three times that 7-9 doubly measures 50% concentration, reflux 8 hours, merge extractive liquid, concentrates and reclaims ethanol, Herba Hyperici perforati extract.
The Radix Astragali water extraction alcohol sedimentation method: get the Radix Astragali, 20 mesh sieves are pulverized, and extracting in water filters, suitably concentrate the back and adopt ethanol to precipitate, precipitate with ethanol again after supernatant suitably concentrates, supernatant reclaims ethanol, concentrate Radix Astragali extract.
Except that the independent extraction of above-mentioned medical material, described Radix Isatidis, Radix Glycyrrhizae, all right mixed extraction of Herba Hyperici perforati are mainly: Radix Isatidis, Radix Glycyrrhizae, the Herba Hyperici perforati medical material of learning from else's experience and pulverizing, and boiling water boils to be carried, filter, merging filtrate, and filtrate is suitably concentrated; Add ethanol and carry out precipitate with ethanol in concentrated solution, leave standstill, supernatant reclaims ethanol, is condensed into extractum, gets medicinal substances extract.
Isatis root and astragalus microspheres for injections diameter of the present invention is 1～250 μ m, and 4,000～9000, the biodegradable medicinal high polymer adjuvant between 000 is formed by the molecular weight ranges of microsphere gross weight 35～90%.
Microsphere of the present invention can adopt the conventional preparation method of microsphere to make, promptly adopt the emulsifying dispersion method to make, implementation step comprises: use dichloromethane, chloroform, ethyl acetate, dioxane, ether, acetone, oxolane, glacial acetic acid and the mixed acid be made up of them are medicinal substances extract and the dissolving of biodegradable pharmaceutic adjuvant, wherein the bulking value percent of pharmaceutic adjuvant in organic solvent is 1～30%, the emulsifying agent that organic facies adopts is the nonionic emulsifier of HLB=4.5～6.0, use polyvinyl alcohol, polyvinyl pyrrolidone, consumption are 0.01～12% of organic facies; Sodium polymethacrylate, sodium polyacrylate, sodium carboxymethyl cellulose solution in addition, prepare continuous water, wherein they are 0.01～10.0 in the percetage by weight of aqueous phase, the emulsifying agent of aqueous phase is the nonionic emulsifier of HLB=14.0～15.5, consumption is 0.01～12% of a water, and the volume ratio of organic facies and water is 1: 4～100; Decentralized photo slowly is injected in the continuous phase by tubule, fully emulsified after, the formed microsphere of sieving separating is drying to obtain.
Isatis root and astragalus microsphere of the present invention be will make the microsphere sterilized powder earlier in aseptic 0.9% normal saline solvent suspendible evenly the back intramuscular administration treat.The drug release process of most of conventional dosage forms is all undertaken by first order kinetics, and the blood drug level of its medicine might be lower than minimum effective blood drug concentration and hold time short shortcoming in treatment concentration.For reaching therapeutic purposes and reducing side effect and often take repeatedly medicining mode, the compliance that makes the patient take medicine like this descends.Slow releasing preparation has overcome the deficiency of conventional formulation just, and steady, persistent blood drug level is provided.
The invention has the beneficial effects as follows: Radix Isatidis, Radix Glycyrrhizae, Herba Hyperici perforati, Milkvetch Root are extracted the back make microsphere, can reach non-lentamente constant release, reduce and take number of times, improve the purpose of patient's compliance with suitable adjuvant.The extraction process of uses advanced is separated effective monomer in the medical material, extracts the back and makes microsphere with suitable adjuvant.Effective ingredient in the Chinese herbal medicine is slowly discharged.The effective ingredient that extracts in the prescription is the formation of blocking virus nucleic acid directly, suppress duplicating and breeding of virus, but and the humoral immunization of enhancing body and cellular immunization, this invention medicine has the body of inducing generation interferon simultaneously, enhancing antibody forms, strengthen the phagocytosis of macrophage to pathogen, thus effective kill virus.
Medicine of the present invention is external to have direct killing action to infectious bronchitis virus; Model to artificial challenge's infectious bronchitis virus also has significant protection and therapeutical effect.Clinical research confirmation medicine of the present invention has excellent curative to infectious bronchitis virus, especially can remove heating that viral infection causes rapidly, improve symptom, promote sick fowl to recover to search for food, promote laying rate and egg product matter to recover, second day clinical symptoms alleviated rapidly after the general medication, recovery from illness in 3～5 days, the curative effect highly significant.
This medicine is human body immunity improving power effectively, and anti-virus ability is strong, the clinical viral diseases such as treatment poultry infectious bursal disease, atypical newcastle disease, infectious bronchitis that are mainly used in.Reasonable recipe, the variation of heat clearing away approach has taken into full account the thermotaxic characteristics of birds, and the pestilence of dispelling the heat, dispel alleviates the sense of discomfort of body, thereby alleviates the symptom of disease to a great extent, increases disease fowl appetite, promotes the rehabilitation of disease fowl.
Be summarized as follows:
(1) goes out a kind of novel formulation of preventing and treating avian viral diseases, improving body disease-resistant power for clinical development.
(2) reasonable recipe, the absorption rate height, the slow release lasting medicine, anti-virus ability is strong, and selected medicine is efficient medicine.
(3) technology advanced person, preparation method is simple, preparation stabilization, lasting medicine, storage period is long.
(4) medicament sources is extensive, cost is low, safely, have no side effect, is difficult for producing drug resistance, meets the international hygiene touchstone.It is remarkable to be used in particular for treating effects such as birds infectious bursal disease, atypical newcastle disease, infectious bronchitis.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
Get Radix Isatidis 300g, Radix Glycyrrhizae 100g, Herba Hyperici perforati 250g, Radix Astragali 350g will be through Radix Glycyrrhizae, the Herba Hyperici perforati of pulverizing, and decocting boils 2 times, add 7 times of water gagings at every turn, each 2 hours, merge decoction liquor, filter, filtrate is concentrated into 900ml, adds 95% ethanol, make determining alcohol reach 70%, left standstill 12～24 hours, and filtered, reclaim ethanol; Continue to be condensed into the Radix Glycyrrhizae Herba Hyperici perforati extract; To decoct with water 2 times through the Radix Astragali of pulverizing, add 6 times of water gagings at every turn, extracted successively 2 hours, 1 hour, merging filtrate is when being concentrated into the 1500ml left and right sides, adding 95% ethanol, to make determining alcohol be 60%, left standstill 12～24 hours, filters, filtrate recycling ethanol, when being concentrated into the 400ml left and right sides, adding 95% ethanol, to make determining alcohol be 80%, left standstill 12～24 hours, filter, filtrate recycling ethanol, and continue to be condensed into Radix Astragali extract; Add 5 times of water gagings by measuring Radix Isatidis, reflux, extract, 5 hours is collected volatile oil.
Comprise that 5～65% the extract by Chinese crude drug is that 35～90% molecular weight ranges of active component and microsphere weight is 4,000～9000, biodegradable medicinal high polymer adjuvant between 000 dalton is formed, and described medicinal high polymer adjuvant is selected from polylactide-co-glycolide, polylactic acid, polyglycolic acid, poly--the 3-butyric ester, polylactic acid-polyglycolic acid, polylactic acid. glycolic, poly-adjacent ester, polylactone, polyanhydride, poly butyric ester-hydroxyl pentanoate copolymer, polyglycolic acid, the polypropylene glucosan, hydroxyacetic acid, polylactic acid-polyglycol, polyglycolic acid. Polyethylene Glycol one or more mixing wherein.
The preparation method of microsphere: above-mentioned 100mg medicinal substances extract, 200mg polylactide-co-glycolide are dissolved in the 3ml dichloromethane, select its molecular weight of polylactide-co-glycolide between 9000～13000 dalton; Lactide and Acetic acid, hydroxy-, bimol. cyclic ester polymerization ratio are between 40: 60～60: 40 in the polylactide-co-glycolide; With syringe under high degree of agitation with it to being equipped with in the three-necked bottle of 10%PVA that 300ml includes the 3.5Ghlb=14 emulsifying agent, after fully emulsified 1 hour, under the pressure of 30 ℃ of 0.03MPa, solvent flashing 1.5 hours, centrifugalize, wash reactant three times with distillation, in 30 ℃ of vacuum drying ovens, dry, 30 ℃ of sterilizations 48 hours, guarantee that residual ethylene oxide content is below 5ppm with oxirane, fill adopts the emulsifying dispersion method to make microsphere; Record particle diameter 1～50 μ m, mean diameter 13.26 μ m, sterilization, packing.
Embodiment 2
Get Radix Isatidis 149g, Radix Glycyrrhizae 122g, Herba Hyperici perforati 314g, Radix Astragali 415g will be through Radix Glycyrrhizae, the Herba Hyperici perforati of pulverizing, and decocting boils 2 times, add 7 times of water gagings at every turn, each 2 hours, merge decoction liquor, filter, filtrate is concentrated into 900ml, adds 95% ethanol, make determining alcohol reach 70%, left standstill 12～24 hours, and filtered, reclaim ethanol; Continue to be condensed into the Radix Glycyrrhizae Herba Hyperici perforati extract; To decoct with water 2 times through the Radix Astragali of pulverizing, add 6 times of water gagings at every turn, extracted successively 2 hours, 1 hour, merging filtrate is when being concentrated into the 1500ml left and right sides, adding 95% ethanol, to make determining alcohol be 60%, left standstill 12～24 hours, filters, filtrate recycling ethanol, when being concentrated into the 400ml left and right sides, adding 95% ethanol, to make determining alcohol be 80%, left standstill 12～24 hours, filter, filtrate recycling ethanol, and continue to be condensed into Radix Astragali extract; Add 5 times of water gagings by measuring Radix Isatidis, reflux, extract, 5 hours is collected volatile oil.
The preparation method of microsphere: above-mentioned 100mg medicinal substances extract, 200mg polylactide-co-glycolide are dissolved in the 3ml dichloromethane, select its molecular weight of polylactide-co-glycolide between 9000～13000 dalton; Lactide and Acetic acid, hydroxy-, bimol. cyclic ester polymerization ratio are between 40: 60～60: 40 in the polylactide-co-glycolide; With syringe under high degree of agitation with it to being equipped with in the three-necked bottle of 10%PVA that 300ml includes the 3.5Ghlb=14 emulsifying agent, after fully emulsified 1 hour, under the pressure of 30 ℃ of 0.03MPa, solvent flashing 1.5 hours, centrifugalize, wash reactant three times with distillation, in 30 ℃ of vacuum drying ovens, dry, 30 ℃ of sterilizations 48 hours, guarantee that residual ethylene oxide content is below 5ppm with oxirane, fill adopts the emulsifying dispersion method to make microsphere; Record particle diameter 1～50 μ m, mean diameter 13.26 μ m, sterilization, packing.
Other is with embodiment 1.
Embodiment 3
Get Radix Isatidis 331g, Radix Glycyrrhizae 165g, Herba Hyperici perforati 312g, Radix Astragali 192g will be through Radix Glycyrrhizae, the Herba Hyperici perforati of pulverizing, and decocting boils 2 times, add 7 times of water gagings at every turn, each 2 hours, merge decoction liquor, filter, filtrate is concentrated into 900ml, adds 95% ethanol, make determining alcohol reach 70%, left standstill 12～24 hours, and filtered, reclaim ethanol; Continue to be condensed into the Radix Glycyrrhizae Herba Hyperici perforati extract; To decoct with water 2 times through the Radix Astragali of pulverizing, add 6 times of water gagings at every turn, extracted successively 2 hours, 1 hour, merging filtrate is when being concentrated into the 1500ml left and right sides, adding 95% ethanol, to make determining alcohol be 60%, left standstill 12～24 hours, filters, filtrate recycling ethanol, when being concentrated into the 400ml left and right sides, adding 95% ethanol, to make determining alcohol be 80%, left standstill 12～24 hours, filter, filtrate recycling ethanol, and continue to be condensed into Radix Astragali extract; Add 5 times of water gagings by measuring Radix Isatidis, reflux, extract, 5 hours is collected volatile oil.
The preparation method of microsphere: with above-mentioned 100mg medicinal substances extract, the 200mg polylactide-co-glycolide is dissolved in the 3ml dichloromethane, with syringe under high degree of agitation with it to being equipped with in the three-necked bottle of 10%PVA that 300ml includes the 3.5Ghlb=14 emulsifying agent, after fully emulsified 1 hour, under the pressure of 30 ℃ of 0.03MPa, solvent flashing 1.5 hours, centrifugalize, wash reactant three times with distillation, in 30 ℃ of vacuum drying ovens, dry, sterilized 48 hours at 30 ℃ with oxirane, guarantee residual ethylene oxide content below 5ppm, fill adopts the emulsifying dispersion method to make microsphere; Record particle diameter 1～50 μ m, mean diameter 13.26 μ m, sterilization, packing.
Other is with embodiment 1.
Application example
150 15 Japanese instar chicklings (aseptic through physical examination) are divided into totally 5 groups of A, B, C, D, E, test behind B, C, the strong malicious counteracting toxic substances of D, E group process artificial challenge's 0.3ml infectious bronchitis virus.A group is healthy group, infective virus not, not administration; B organizes negative control group, infective virus, not administration; The C group is pharmaceutical composition low dose group of the present invention, presses 0.1g/ chicken/sky injection; The D group is the pharmaceutical composition high dose group, presses 0.2g/ chicken/sky injection; The E group is fed by 0.2g/ chicken/sky spice for astragalin injection group (Dalian three instrument company limiteies).The result shows, adopts isatis root and astragalus microspheres for injections treatment infectious bronchitis virus disease of the present invention that tangible curative effect is arranged.
Existing drug study result is as follows in medicine injectable microsphere contrast of the present invention:
| Numbering | Group | Mortality rate % | Cure rate % | Effective percentage % |
| A | Healthy group | 0 | 100.0(30/30) | 100.0(30/30) |
| B | Negative control group | 83.3(25/30) | 6.7(2/30) | 16.7(5/30) |
| C | Low dose therapy group of the present invention | 16.7(5/30) | 43.3(13/30) | 70.0(21/30) |
| D | High-dose therapy group of the present invention | 6.7(2/30) | 66.7(20/30) | 86.7(26/30) |
| E | " astragalin injection " treatment group | 20.0(6/30) | 40.0(9/30) | 70.0(21/30) |
This result of the test shows, pharmaceutical composition of the present invention is low, high-dose therapy group and matched group difference highly significant (P＜0.01), illustrates that pharmaceutical composition of the present invention has significant therapeutical effect to the infectious bronchitis virus disease that virus causes; Particularly high dose is used and obviously is better than " astragalin injection " treatment group curative effect (P＜0.01).
Above-mentioned detailed description of isatis root and astragalus microspheres for injections and preparation method thereof being carried out with reference to embodiment; be illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (6)
1, a kind of isatis root and astragalus microspheres for injections, it is characterized in that comprising that 5～65% the extract by Chinese crude drug is that 35～90% molecular weight ranges of active component and microsphere weight is 4,000～9000, biodegradable medicinal high polymer adjuvant between 000 is formed, the composition of its Chinese crude drug % proportioning by weight is: Radix Isatidis 15%～50%, Radix Glycyrrhizae 8%～20%, Herba Hyperici perforati 12%～40%, the Radix Astragali 15%～50%.
2, isatis root and astragalus microspheres for injections according to claim 1 is characterized in that the preferred weight percentage composition of described active component crude drug is: Radix Isatidis 30%, Radix Glycyrrhizae 10%, Herba Hyperici perforati 25%, the Radix Astragali 35%.
3, isatis root and astragalus microspheres for injections according to claim 1 is characterized in that described medicinal high polymer adjuvant is selected from polylactide-co-glycolide, polylactic acid, polyglycolic acid, poly--the 3-butyric ester, polylactic acid-polyglycolic acid, polylactic acid. glycolic, poly-adjacent ester, polylactone, polyanhydride, poly butyric ester-hydroxyl pentanoate copolymer, polyglycolic acid, polypropylene glucosan, hydroxyacetic acid, polylactic acid-polyglycol, polyglycolic acid. and Polyethylene Glycol one or more mixing wherein.
4, isatis root and astragalus microspheres for injections according to claim 1 is characterized in that excellent polylactide-co-glycolide, polylactic acid, the polylactic acid of being selected from of described medicinal high polymer adjuvant. one or more mixing wherein of polyglycolic acid, polylactic acid-glycollic acid, poly butyric ester-hydroxyl pentanoate copolymer.
5, isatis root and astragalus microspheres for injections according to claim 1 is characterized in that described medicinal high polymer adjuvant is a polylactide-co-glycolide; Its molecular weight of described polylactide-co-glycolide is between 9000～13000 dalton; Lactide and Acetic acid, hydroxy-, bimol. cyclic ester polymerization ratio are between 40: 60～60: 40 in the polylactide-co-glycolide.
6, a kind of preparation method of isatis root and astragalus microspheres for injections according to claim 1, promptly adopt the emulsifying dispersion method to make, it is characterized in that implementation step comprises: use dichloromethane, chloroform, ethyl acetate, dioxane, ether, acetone, oxolane, glacial acetic acid and the mixed acid be made up of them are medicinal substances extract and the dissolving of biodegradable pharmaceutic adjuvant, wherein the bulking value percent of pharmaceutic adjuvant in organic solvent is 1～30%, the emulsifying agent that organic facies adopts is the nonionic emulsifier of HLB=4.5～6.0, use polyvinyl alcohol, polyvinyl pyrrolidone, consumption are 0.01～12% of organic facies; Sodium polymethacrylate, sodium polyacrylate, sodium carboxymethyl cellulose solution in addition, prepare continuous water, wherein they are 0.01～10.0 in the percetage by weight of aqueous phase, the emulsifying agent of aqueous phase is the nonionic emulsifier of HLB=14.0～15.5, consumption is 0.01～12% of a water, and the volume ratio of organic facies and water is 1: 4～100; Decentralized photo slowly is injected in the continuous phase by tubule, and emulsifying is sieved then, is drying to obtain.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600383A (en) * | 2012-02-09 | 2012-07-25 | 黑龙江省汇丰动物保健品有限公司 | Chinese medicinal herb preparation for poultry and application thereof |
| CN103110024A (en) * | 2013-03-12 | 2013-05-22 | 山东春雪药业有限公司 | Antiviral feed Chinese herbal medicine additive for broiler chicken and production method thereof |
| CN113559137A (en) * | 2021-08-18 | 2021-10-29 | 安徽中龙神力生物科技有限公司 | Granulating method of veterinary drug granules |
-
2008
- 2008-08-15 CN CNA2008100541416A patent/CN101352486A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600383A (en) * | 2012-02-09 | 2012-07-25 | 黑龙江省汇丰动物保健品有限公司 | Chinese medicinal herb preparation for poultry and application thereof |
| CN102600383B (en) * | 2012-02-09 | 2014-01-15 | 黑龙江省汇丰动物保健品有限公司 | Chinese medicinal herb preparation for poultry and application thereof |
| CN103110024A (en) * | 2013-03-12 | 2013-05-22 | 山东春雪药业有限公司 | Antiviral feed Chinese herbal medicine additive for broiler chicken and production method thereof |
| CN113559137A (en) * | 2021-08-18 | 2021-10-29 | 安徽中龙神力生物科技有限公司 | Granulating method of veterinary drug granules |
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