CN106668072B - One kind disappears rash analgesic gel and preparation method - Google Patents
One kind disappears rash analgesic gel and preparation method Download PDFInfo
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Abstract
Disappear rash analgesic gel and preparation method the invention discloses one kind, the rash analgesic gel that disappears, including Chinese medical extract, gel-type vehicle, high molecular polymer, organic solvent and water, it is characterized in that the Chinese medical extract 55-65%, gel-type vehicle 10-20%, high molecular polymer 1.0-1.5%, organic solvent 1.0-3.5%, remaining as water, the preparation method for disappearing rash analgesic gel includes: the abstraction process of Chinese medical extract, the arrangement step and mixed configuration process of gel-type vehicle, the beneficial effects of the present invention are: present invention employs a variety of medicinal materials such as pheretima, it calms the frightened with heat-clearing, it relievings asthma, dredging collateral, the effects of diuresis, for herpes simplex, genitality bleb and shingles zoster tool have a better effect；A variety of active ingredients is proposed from fresh pheretima using sour water overcoring method, the activity of the drug utmostly retained increases the drug effect of drug.
Description
Technical field:
The invention belongs to externally applied drug technical field, relates more specifically to one kind and disappear rash analgesic gel and preparation method.
Background technique:
Bleb is clinically extremely common illness, shows as herpes simplex, genitality bleb and shingles zoster.Simple blister
Exanthema virus causes herpes simplex, genitality bleb, at abroad, the disease incidence of genitality bleb be only second in venereal disease stranguria syndrome and
Syphilis occupies the third position of venereal disease disease incidence, and closely related with the generation of AIDS, cervical carcinoma etc..Shingles zoster is varicella band
Skin infection caused by shape herpesviral.Its oncoming force is fast, and the in great pain and course of disease is long.
The national inventing patent of Patent No. 201310631458.2 discloses " blood circulation promotion and pain alleviation gel and preparation method thereof ",
The patent of invention arthralgia relief gel have stability is good, rheological characteristic is good, stretchability is good, it is easy to use, small to skin irritation,
The advantages of good effect and production safety.But the patent of invention can not solve bleb illness, therefore seek one kind rash that disappears and stop
Pain natural traditional Chinese medicine compound preparation is extremely urgent, and the rash analgesic gel disclosed by the invention that disappears has significant in efficacy, elimination virus
Advantage, it is expected to exhibit one's skill to the full in the treatment of herpesviral, there are good market prospects in herpes zoster field.
Summary of the invention:
To solve the above problems, overcome the deficiencies in the prior art, the present invention provides it is a kind of it is significant in efficacy, preparation process is simple
Single, cost price is cheap, the rash analgesic gel that disappears that can be eradicated virus, solve the acute skins problems such as bleb, eczema, Neng Gouyou
The rash analgesic that solves the problems, such as to disappear of effect can not solve simultaneously, higher cost and production process are longer.
The present invention solve above-mentioned technical problem the specific technical proposal is: the rash analgesic gel that disappears, including it is Chinese medical extract, solidifying
Gel matrix, high molecular polymer, organic solvent and water, it is characterised in that the weight percent of the rash analgesic gel each component that disappears
Are as follows: Chinese medical extract 55-65%, gel-type vehicle 10-20%, high molecular polymer 1.0-1.5%, organic solvent 1.0-3.5%,
Remaining as water；The Chinese medicine material of the Chinese medical extract includes pheretima or rhizoma corydalis or Fructus Forsythiae or viola mandshurica or the root of Dahurain angelica or life
The mixture of one of Radix Glycyrrhizae or two kinds or more, the Chinese medicine material of the Chinese medical extract is by weight percentage respectively
Imperial 15-25%, rhizoma corydalis 20-30%, Fructus Forsythiae 15-25%, viola mandshurica 15-25%, root of Dahurain angelica 10-15%, licorice 5-10%.
Further, the high molecular polymer is selected from one or two or more kinds of mixing of carbomer or poloxamer
Object.
Further, the organic solvent is selected from ethyl alcohol or one of triethanolamine or ethyl hydroxy benzoate or two kinds or more
Mixture.
Further, the rash that disappears analgesic gel and preparation method include: that the abstraction process of Chinese medical extract, gel-type vehicle are matched
Set process and mixed configuration process.
Further, the abstraction process of the Chinese medical extract includes: to take pheretima 15-25% according to weight percent, prolong
Hu rope 20-30%, Fructus Forsythiae 15-25%, viola mandshurica 15-25%, root of Dahurain angelica 10-15%, licorice 5-10%, featured xeraphium
Medicinal powder is added in 60% ethyl alcohol according to solid-liquid ratio for 1/7-1/9 by broken 10 mesh of mistake, and dipping is after 20-30 hours, by feed liquid
It is placed in percolator, diacolation operation is carried out with 1.5-2.5ml per minute, percolate is collected, is placed in vacuum concentration equipment,
Concentrate is filtered, filtered filtrate is set again by 50-65 DEG C of reduced pressure until concentrate concentration is 1.02-1.04g/L
In vacuum concentration equipment, 50-65 DEG C of reduced pressure obtains A liquid until concentrate concentration is 1.22-1.30g/L；After filtration
Filter cake according to filter cake weight 1.0-1.5% be added poloxamer, according to 15-20% be added distilled water dissolved, obtain
To B liquid, A liquid and B liquid are mixed to get Chinese medical extract.
Further, the arrangement step of the gel-type vehicle includes: by glycerol and distilled water according to weight ratio 20-35/100
Ratio be mixed and stirred for uniformly, carbomer is added according to the 3-5% of glycerite weight, then be stirred to swelling, obtains
To gel-type vehicle.
Further, it according to weight ratio is 60-80/100 ratio that the mixed configuration process, which includes: by ethyl hydroxy benzoate and ethyl alcohol,
Example be mixed and stirred for uniformly, and is 1.4-2/100 ratio according to weight ratio by ethyl hydroxy benzoate ethanol solution and gel-type vehicle
Be mixed and stirred for uniformly, and be that 20-30/100 ratio mixes according to weight ratio by gel-type vehicle and Chinese medical extract,
Triethanolamine is added according to the 2.5-3% of total weight after stirring, adjusts pH value to 6.0-6.5, obtains mixture, will steam
Distilled water and mixture are that distilled water is added in 25-35/100 according to weight ratio, and mixing stands and obtains the rash analgesic gel that disappears, finally divides
Dress.
The beneficial effects of the present invention are: present invention employs a variety of medicinal materials such as pheretima, there is heat-clearing to calm the frightened, relieving asthma, dredging collateral,
The effects of diuresis, has a better effect herpes simplex, genitality bleb and shingles zoster tool；Using sour water overcoring method
A variety of active ingredients is proposed from fresh pheretima, the activity of the drug utmostly retained increases the drug effect of drug；Reasonable medicine
Object collocation, substantially increases the pharmacological effect of drug, and than the use that the prior art reduces medicament categories, drug price is cheap big
Drug cost is reduced greatly.
Specific embodiment:
It is further below by specific implementation for more intuitive, system and detailed statement protection content of the invention
Illustrate that technical solution of the present invention, following embodiment are merely to illustrate the present invention rather than limit the scope of the invention.For
For those skilled in the art, any change for being made within the scope of the present invention is modified or is directlyed adopt same in embodiment
Etc. conditions and the example implemented, be understood in covering scope of the invention.Specific embodiment is as follows:
Embodiment one:
The present embodiment is illustrated that specific step is as follows by taking 800g Chinese herbal medicine as an example:
1. taking pheretima 150g, rhizoma corydalis 200g, Fructus Forsythiae 150g, viola mandshurica 150g, root of Dahurain angelica 100g, licorice 50g, altogether
800g, featured drying and crushing cross 10 meshes, and medicinal powder is added to according to solid-liquid ratio for 1:7 60% ethanol water of 5600ml
In, feed liquid is placed in percolator by dipping after 20 hours, carries out diacolation operation with 1.5ml per minute, 4500ml percolate is received
Collection, is placed in vacuum concentration equipment, and concentrate is filtered, mistake by 50 DEG C of reduced pressures until concentrate concentration is 1.02g/L
Filtrate after filter is placed in vacuum concentration equipment again, and 50 DEG C of reduced pressures obtain A liquid until concentrate concentration is 1.22g/L；In
Poloxamer is added according to the 1.0% of filter cake weight in filtered filter cake, is dissolved, is obtained according to 15% addition distilled water
A liquid and B liquid are mixed to get the total 2400ml of Chinese medical extract by B liquid.
2. glycerol 80g and distilled water 400g is taken be mixed and stirred for uniformly, being added and blocking according to the 3% of glycerite weight
Wave nurse 14.4g, then be stirred to swelling, obtain gel-type vehicle.
3. ethyl hydroxy benzoate 3g and ethyl alcohol 5g is taken to be mixed and stirred for uniformly, obtaining ethyl hydroxy benzoate ethanol solution, taking ethyl hydroxy benzoate
Ethyl alcohol 7.2g, is added in the gel-type vehicle of 494.4g, is uniformly mixed, mixed gel-type vehicle is then added to step 1
Chinese medical extract in, 72.5g triethanolamine is added according to the 2.5% of total weight after stirring, adjusts pH value to 6.0,
Mixture is obtained, distilled water 1000ml is added, mixing stands and obtains gel, finally dispenses.
Embodiment two:
The present embodiment is illustrated that specific step is as follows by taking 800g Chinese herbal medicine as an example:
1. taking pheretima 150g, rhizoma corydalis 200g, Fructus Forsythiae 150g, viola mandshurica 150g, root of Dahurain angelica 100g, licorice 50g, altogether
800g, featured drying and crushing cross 10 meshes, and medicinal powder is added to according to solid-liquid ratio for 1:9 60% ethanol water of 7200ml
In, feed liquid is placed in percolator by dipping after 20 hours, carries out diacolation operation with 1.5ml per minute, 6000ml percolate is received
Collection, is placed in vacuum concentration equipment, and concentrate is filtered, mistake by 50 DEG C of reduced pressures until concentrate concentration is 1.04g/L
Filtrate after filter is placed in vacuum concentration equipment again, and 65 DEG C of reduced pressures obtain A liquid until concentrate concentration is 1.30g/L；In
Poloxamer is added according to the 1.5% of filter cake weight in filtered filter cake, is dissolved, is obtained according to 20% addition distilled water
A liquid and B liquid are mixed to get Chinese medical extract by B liquid, and A liquid and B liquid are mixed to get the total 2800ml of Chinese medical extract.
2. glycerol 140g and distilled water 400g is taken be mixed and stirred for uniformly, being added according to the 5% of glycerite weight
Carbomer 27g, then be stirred to swelling, obtain gel-type vehicle.
3. ethyl hydroxy benzoate 8g and ethyl alcohol 10g is taken to be mixed and stirred for uniformly, obtaining ethyl hydroxy benzoate ethanol solution, taking ethyl hydroxy benzoate
Ethyl alcohol 10.8g, is added in the gel-type vehicle of 567g, is uniformly mixed, mixed gel-type vehicle is then added to step 1
In Chinese medical extract, triethanolamine 101g triethanolamine is added according to the 3% of total weight after stirring, adjusts pH value extremely
6.0, mixture is obtained, distilled water 1000ml is added, mixing stands and obtains gel, finally dispenses.
Embodiment three
The present embodiment is illustrated that specific step is as follows by taking 800g Chinese herbal medicine as an example:
1. taking pheretima 150g, rhizoma corydalis 200g, Fructus Forsythiae 150g, viola mandshurica 150g, root of Dahurain angelica 100g, licorice 50g, altogether
800g, featured drying and crushing cross 10 meshes, and medicinal powder is added to according to solid-liquid ratio for 1:8 60% ethanol water of 6400ml
In, feed liquid is placed in percolator by dipping after 20 hours, carries out diacolation operation with 2ml per minute, 5200ml percolate is received
Collection, is placed in vacuum concentration equipment, and concentrate is filtered, mistake by 60 DEG C of reduced pressures until concentrate concentration is 1.01g/L
Filtrate after filter is placed in vacuum concentration equipment again, and 60 DEG C of reduced pressures obtain A liquid until concentrate concentration is 1.26g/L；In
Poloxamer is added according to the 1.2% of filter cake weight in filtered filter cake, is dissolved, is obtained according to 17% addition distilled water
A liquid and B liquid are mixed to get Chinese medical extract by B liquid.A liquid and B liquid are mixed to get the total 2560ml of Chinese medical extract.
2. glycerol 100g and distilled water 400g is taken be mixed and stirred for uniformly, being added according to the 4% of glycerite weight
Carbomer 20g, then be stirred to swelling, obtain gel-type vehicle.
3. ethyl hydroxy benzoate 3g and ethyl alcohol 5g is taken to be mixed and stirred for uniformly, obtaining ethyl hydroxy benzoate ethanol solution, taking ethyl hydroxy benzoate
Ethyl alcohol 8g, is added in the gel-type vehicle of 520g, is uniformly mixed, then mixed gel-type vehicle is added in step 1
In medicament extract, triethanolamine 80g triethanolamine is added according to the 2.6% of total weight after stirring, adjusts pH value extremely
6.0, mixture is obtained, distilled water 1000ml is added, mixing stands and obtains gel, finally dispenses.
Beneficial effects of the present invention: show product advantage of the invention in order to more intuitive, spy is with produced by the invention
The similar prescription (preferential indication is identical, the similar leading market kind of prescription) that the rash that disappears analgesic gel is produced with the prior art,
Clinical drug requirement standard is detected according to state food drug surveilance general bureau, testing result is as follows:
1 present invention of table and the similar prescription of prior art production compare
In terms of the result of 1 comparative test of table:
The leading products of the present invention and the similar prescription of prior art production compare, and the above preparation is for pure blister
Rash, genitality bleb and shingles zoster all have conspicuousness curative effect, but above-mentioned test article is liquid preparation in addition to this product, and
This product is gel preparation, and gel preparation has a significant advantage that gel is solid for transparent half relative to liquid preparation in external drug
Body, it is homogeneous, have the characteristics that water-soluble base, painting can form transparent film on the skin, and adhesion is strong, without greasy,
Not pollution clothes, it is washable, it is good with skin coupling effect, and it is fast to release the drug, rapidly, and drug can be improved from contact site in effect
It absorbs, avoids first pass effect, the bioavilability of drug can be improved.
Show product advantage of the invention in order to more intuitive, it is special with it is produced by the invention disappear rash analgesic gel with it is existing
The gel preparation I (a kind of swelling reducing and pain easing gel cream of national inventing patent 201510638732.8) and the prior art of technology production are raw
The gel preparation II (201510325222.5 arthralgia relief gel of national inventing patent and preparation method thereof) of production compares, and presses
Clinical drug requirement standard is detected according to state food drug surveilance general bureau, testing result is as follows:
2 present invention of table and the gel preparation of prior art production compare
In terms of the result of 2 comparative test of table:
The prior art disclosed in the present invention and national inventing patent compares, and the above test article all has significant analgesic
Curative effect, and above-mentioned test article is gel preparation；But the above test article in addition to this product for herpes simplex, genitality blister
Rash and the equal inefficacy of shingles zoster；And gel preparation I uses the rare medicinal herbs such as borneol, Radix Angelicae Sinensis and peppermint, relative to this product
It is higher with II production cost of gel preparation.
The present invention has significant therapeutic effect to bleb, shingles zoster, and relevant case is as follows:
1 Guo of case, male, 39 years old, cadre
There is mild pain on remote holder in 3 days in [main suit], just has small red dot later, then just grows the water of size as the grain of rice
Bubble.
[present illness history] is single or cluster vesicle, 10 or so assemblies together, are itched bitterly.Erythrosis around bubble,
There are slight titillation and fever simultaneously.
38.1 DEG C of [physical examination] body temperature, blood pressure 106/80mmHg, ordinary circumstance can.Heart and lung auscultation and abdomen physical examination not and
It is obvious abnormal.Left upper extremity is dispersed in the intensive vesicle of mung bean size, basal part flush, Zhu Qun along the centre of the palm to upper arm visible more than 10
Visible normal skin interval between vesicle, left upper extremity skin because quite sensitive refusal touch, left armpit can and one piece of semen viciae fabae it is big
Small lymph node, mobility can, tenderness is obvious.Opposite side upper limb is normal.
[diagnosis] bleb
[treatment] with after 1 week of rash analgesic gel that disappears, symptom has clear improvement, and bubble forms the crust of dark brown, then
Drying falls off and fully recovers.
2 Mr. Wang, male of case, 78 years old, peasant.
[main suit] left upper extremity eruption site skin has neuralgia and burning heat sensation 3 days, aggravates 1 day.
Before [present illness history] 4 days, there is grade fever, general malaise, loss of appetite, upper left in the night after field labour in patient
Limb cutaneous sensibility increases phenomenon, burn feeling, itch, touching such as picotement,.To night next day, it is found that left hand slaps several blisters
Rash, blister about mung bean size, the smooth similar pearl in surface, blister wall is transparent, thick and nervous, around around with blush.With cusalgia, no scabies
Itch, vesicle significantly increases and spread to successively left upper arm over nearly one day, and cusalgia sense continues, cannot touch, night is difficult to sleep, and companion
There are slight chilly, fever sense.Since illness, spirit is slightly worse, feels out of strength obvious, no to cough, without thorax abdomen pain, diet slightly has
It reduces, two just without obvious exception.
38.1 DEG C of blood pressure 110/80mmHg ordinary circumstances of [physical examination] body temperature can.Heart and lung auscultation and abdomen physical examination are not and bright
It is aobvious abnormal.
[diagnosis] shingles zoster
[treatment] with after 1 week of rash analgesic gel that disappears, symptom has clear improvement, and blister dry incrustation after decrustation, is stayed
There is temporary pigmentation.
3 Lee of case, male, the age 18 years old, student.
[main suit] right hand forearm and palm have the bubble to differ in size 3 days.Part is gently itched, and pain is obvious.
The right hand forearm without inducement starts the cluster bubble for occurring differing in size before [present illness history] patient is derived from three days.Have
Tenderness.
[physical examination] body temperature etc. is normal, and pharyngeal slightly congested, double pulmonary respiration sounds are clear, does not hear and dry moist rales.Heart
It checks without exception.Abdomen is put down soft.Backbone and four limbs check without exception.
[diagnosis] shingles zoster
[treatment] with after 1 week of rash analgesic gel that disappears, symptom has clear improvement, and blister dry incrustation after decrustation, is stayed
There is temporary pigmentation.
Case 4 weeks certain, male, 80 years old, retired worker
More than 10 day of waist-leg dermexanthesis on the right side of [main suit] aggravates 5 days with pain 1 day.
There is left lumbar without obvious inducement before more than 10 day of [present illness history] patient to itch, discovery left lumbar goes out red mound
Rash, amount is few, not bitterly.Oneself smear ointment (specific ointment is unknown) 3 days, without being clearly better and increased significantly, part fash increases
There is pain before one day in big blebbing, burnt sample pain in duration.
36.8 DEG C of blood pressure 110/70mmHg of [physical examination] body temperature.Whole skin sclera has no xanthochromia, right side waist buttocks, big
Leg front side, inside, groin, surrounding genital are shown in kermesinus fash, not of uniform size, and part goes out blister and ulceration.Superficial lymph knot
Not enlargement.Double lung percussion voicelesss sound, breath sound is clear, does not hear and dry and wet rale.Cardiac work up is without exception.Abdomen is flat, soft.Ridge
Column, four limbs are without deformity, and activity is freely.
[diagnosis] shingles zoster
[treatment] with after 1 week of rash analgesic gel that disappears, symptom has clear improvement, and blister dry incrustation after decrustation, is stayed
There is temporary pigmentation.
5 Zhang of case, female, 51 years old, worker
[main suit] bilateral eye socket pain 3 days, there is bleb 2 days in left side.
Private prosecution eyes socket of the eye pain finds no epidermal damage, 1 day rear left with slight headache, dizziness before [present illness history] patient 3 days
There is exanthema vesiculosum in side forehead, and pain is obvious, and phlycten occur in discovery left side upper eyelid and temporo area and left side scalp from this morning
Rash.Skin lesion is mainly shown as on the basis of edematous erythema in the cybotaxis papulo-vesicle and blister of the distribution of more clusters, and grain grain is to green
Beans size, tonic vesicle wall is shinny, the transparent clarification of blister liquid.
37.5 DEG C of blood pressure 110/70mmHg of [physical examination] body temperature, ordinary circumstance can.Heart and lung auscultation and abdomen physical examination not and
It is obvious abnormal.
[diagnosis] shingles zoster
[treatment] with after 1 week of rash analgesic gel that disappears, symptom has clear improvement, and blister dry incrustation after decrustation, is stayed
There is temporary pigmentation.
Case 6 it is bent so-and-so, male, 65 years old, retired cadre
[main suit] because of right abdomen back pain 20 days, companion was admitted to hospital for eruption 18 days.
There is right abdomen back pain without obvious inducement before [present illness history] patient 20 days, is in cutting pains, intermittent attack,
Every time for about the several seconds etc..Do not give specially treated at that time.Occur being in zonal distribution red bleb, companion in afflicted areas after 2 days
The pain increased, no itch, and no exudation takes acyclovir slice 5 days certainly, and bleb subsides gradually, but pain does not subtract.Relapse rate hair
Make, local skin hyperalgia, ache influence sleep.
The visible large stretch of shingles zoster spot in abdomen back, part have been formed a scab on the right side of [physical examination], a little pigmentation, surrounding skin without
The pain of redness, no exudation, local skin hyperalgia, touching is obviously aggravated.
[diagnosis] shingles zoster
[treatment] with after 1 week of rash analgesic gel that disappears, symptom has clear improvement, and blister dry incrustation after decrustation, is stayed
There is temporary pigmentation.
In summary: the present invention not only has effects that the rash that disappears, and also has effects that analgesic, and simple production process,
Low production cost, curative effect of medication stablize, also have the effects that heat-clearing calm the frightened, relieving asthma, dredging collateral, diuresis, compared with the existing technology
Other like products have substantive distinguishing features outstanding and significant progress.
Claims (7)
- The rash analgesic gel 1. one kind disappears, including Chinese medical extract, gel-type vehicle, high molecular polymer, organic solvent and water, it is special Sign is the weight percent of the rash analgesic gel each component that disappears are as follows: Chinese medical extract 55-65%, gel-type vehicle 10-20%, height Molecularly Imprinted Polymer 1.0-1.5%, organic solvent 1.0-3.5%, remaining as water；The Chinese medicine material of the Chinese medical extract is by weight Percentage be respectively pheretima 15-25%, rhizoma corydalis 20-30%, Fructus Forsythiae 15-25%, viola mandshurica 15-25%, root of Dahurain angelica 10-15%, life it is sweet Careless 5-10%.
- 2. the rash analgesic gel according to claim 1 that disappears, it is characterised in that the high molecular polymer be selected from carbomer or One or two or more kinds of mixtures of poloxamer.
- 3. the rash analgesic gel according to claim 1 that disappears, it is characterised in that the organic solvent is selected from ethyl alcohol or three ethyl alcohol The mixture of one of amine or ethyl hydroxy benzoate or two kinds or more.
- 4. a kind of preparation method of the rash analgesic gel as claimed in any one of claims 1 to 3 that disappears, characterized by comprising: in The abstraction process of medicament extract, the arrangement step of gel-type vehicle and mixed configuration process.
- 5. the preparation method of the rash analgesic gel according to claim 4 that disappears, it is characterised in that the Chinese medical extract mentions Take process include: according to weight percent take pheretima 15-25%, rhizoma corydalis 20-30%, Fructus Forsythiae 15-25%, viola mandshurica 15-25%, Root of Dahurain angelica 10-15%, licorice 5-10%, featured drying and crushing cross 10 meshes, are added to medicinal powder for 1/7-1/9 according to solid-liquid ratio In 60% ethyl alcohol, feed liquid is placed in percolator by dipping after 20-30 hours, carries out diacolation operation with 1.5-2.5ml per minute, Percolate is collected, is placed in vacuum concentration equipment, 50-65 DEG C of reduced pressure, until concentrate concentration is 1.02-1.04g/L, it will Concentrate is filtered, and filtered filtrate is placed in vacuum concentration equipment again, 50-65 DEG C of reduced pressure, until concentrate concentration For 1.22-1.30g/L, A liquid is obtained；Poloxamer is added according to the 1.0-1.5% of filter cake weight in filter cake after filtration, presses Distilled water is added according to 15-20% to be dissolved, obtains B liquid, A liquid and B liquid is mixed to get Chinese medical extract.
- 6. the preparation method of the rash analgesic gel according to claim 4 that disappears, it is characterised in that the configuration of the gel-type vehicle Process includes: be mixed and stirred for uniformly, according to glycerite according to weight ratio 20-35/100 ratio by glycerol and distilled water Carbomer is added in the 3-5% of weight, then is stirred to swelling, obtains gel-type vehicle.
- 7. the preparation method of the rash analgesic gel according to claim 4 that disappears, it is characterised in that the mixed configuration process packet It includes: by ethyl hydroxy benzoate and ethyl alcohol according to weight ratio being that 60-80/100 ratio be mixed and stirred for uniformly, and by ethyl hydroxy benzoate second Alcoholic solution and gel-type vehicle be mixed and stirred for uniformly according to weight ratio for 1.4-2/100 ratio, and by gel-type vehicle in Medicament extract is that 20-30/100 ratio is mixed according to weight ratio, is added after stirring according to the 2.5-3% of total weight Enter triethanolamine, adjusts pH value to 6.0-6.5, obtain mixture, distilled water and mixture are added according to weight ratio for 25-35/100 Enter distilled water, mixing stands and obtains the rash analgesic gel that disappears, finally dispenses.
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| CN114569663B (en) * | 2022-03-31 | 2023-03-31 | 成都中医药大学附属医院 | Pharmaceutical composition and preparation method and application thereof |
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