CN105769811A - Empty starch capsule and preparation method thereof - Google Patents
Empty starch capsule and preparation method thereof Download PDFInfo
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- CN105769811A CN105769811A CN201610293020.1A CN201610293020A CN105769811A CN 105769811 A CN105769811 A CN 105769811A CN 201610293020 A CN201610293020 A CN 201610293020A CN 105769811 A CN105769811 A CN 105769811A
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- propolis
- carrageenan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Botany (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Jellies, Jams, And Syrups (AREA)
Abstract
The invention discloses an empty starch capsule and a preparation method thereof. The empty starch capsule is prepared from 18-20 parts of starch, 8-10 parts of glycerin, 10-12 parts of chitin, 10-14 parts of acetic acid, 12-16 parts of calcium alginate, 10-18 parts of ethyl cellulose, 8-10 parts of succinic anhydride, 8-12 parts of fresh edible fungi polysaccharide, 10-12 parts of guar gum, 12-16 parts of carrageenan, 12-18 parts of propolis, 10-14 parts of sorbitol, 8-16 parts of soy protein, 12-18 parts of pericarpium citri reticulatae and 10-16 parts of chrysanthemum. The empty starch capsule is good in taste and rich in nutrition and has a healthcare function.
Description
Technical field
The present invention relates to a kind of starch hollow capsule and preparation method thereof.
Background technology
Capsules is added, by pharmagel, the cap that adjuvant refines, body two saves capsule shells and forms.It is mainly used in containing solid drugs.As made powder, health product, medicament etc. by oneself, for the problem that user solves difficult entrance, mouthfeel difference, it is truly realized good medicine no longer bitter to the taste.Capsules is becoming increasingly popular, first the elongate form of capsule, it is easy to swallow, and is dosage form most popular with consumers；Additionally, uncomfortable taste and the abnormal smells from the patient of content can very effectively be covered by capsule.The size of capsule has varied, lengthens and No. 5 capsules including No. 00.Capsule also can stamp word, trade mark and pattern, present the customization outward appearance of uniqueness.The shortcoming that existing Capsules exists mouthfeel difference, nutritional labeling is low, do not have health care.
Summary of the invention
The technical problem to be solved in the present invention is to provide that a kind of mouthfeel is good, nutritious and the starch hollow capsule with health care and preparation method thereof.
For solving above-mentioned technical problem, the present invention adopts the following technical scheme that
A kind of starch hollow capsule and preparation method thereof, is made up of following raw material: starch, glycerol, chitin, acetic acid, calcium alginate, ethyl cellulose, succinic anhydride, fresh mushroom polysaccharide, guar gum, carrageenan, propolis, sorbitol, soybean protein, Pericarpium Citri Reticulatae and Flos Chrysanthemi；Described raw material is by following parts by weight proportioning composition: starch 18 20 parts, glycerol 8 10 parts, chitin 10 12 parts, acetic acid 10 14 parts, calcium alginate 12 16 parts, ethyl cellulose 10 18 parts, succinic anhydride 8 10 parts, fresh mushroom polysaccharide 8 12 parts, guar gum 10 12 parts, carrageenan 12 16 parts, propolis 12 18 parts, sorbitol 10 14 parts, soybean protein 8 16 parts, Pericarpium Citri Reticulatae 12 18 parts and Flos Chrysanthemi 10 16 parts.
Further, described raw material is by following parts by weight proportioning composition: starch 18 parts, glycerol 10 parts, chitin 12 parts, acetic acid 14 parts, calcium alginate 16 parts, ethyl cellulose 18 parts, succinic anhydride 10 parts, fresh mushroom polysaccharide 12 parts, guar gum 12 parts, carrageenan 16 parts, propolis 18 parts, sorbitol 14 parts, soybean protein 16 parts, Pericarpium Citri Reticulatae 18 parts and Flos Chrysanthemi 16 parts.
Further, described raw material is by following parts by weight proportioning composition: starch 19 parts, glycerol 9 parts, chitin 11 parts, acetic acid 12 parts, calcium alginate 14 parts, ethyl cellulose 14 parts, succinic anhydride 9 parts, fresh mushroom polysaccharide 10 parts, guar gum 11 parts, carrageenan 14 parts, propolis 15 parts, sorbitol 12 parts, soybean protein 12 parts, Pericarpium Citri Reticulatae 15 parts and Flos Chrysanthemi 13 parts.
Further, described raw material is by following parts by weight proportioning composition: starch 20 parts, glycerol 8 parts, chitin 10 parts, acetic acid 10 parts, calcium alginate 12 parts, ethyl cellulose 10 parts, succinic anhydride 8 parts, fresh mushroom polysaccharide 8 parts, guar gum 10 parts, carrageenan 12 parts, propolis 12 parts, sorbitol 10 parts, soybean protein 8 parts, Pericarpium Citri Reticulatae 12 parts and Flos Chrysanthemi 10 parts.
The preparation method that another technical problem that the invention solves the problems that is to provide a kind of starch hollow capsule, includes following steps:
1) take starch 18 20 parts, glycerol 8 10 parts, chitin 10 12 parts and acetic acid 10 14 parts, put in blender, stir；
2) putting in heater by the above-mentioned material stirred, temperature rises to 60 80 DEG C, heats 15 20min, standby；
3) take Pericarpium Citri Reticulatae 12 18 parts and Flos Chrysanthemi 10 16 parts is put in jet mill, prepare the powder of 100 130 orders, standby；
4) taking calcium alginate 12 16 parts, ethyl cellulose 10 18 parts, succinic anhydride 8 10 parts and fresh mushroom polysaccharide 8 12 parts, put in a container, add the deionized water of 0.5 times, temperature rises to 30 50 DEG C, heats while stirring；
5) by step 2) and step 3 in prepare material add step 4 to) in, add guar gum 10 12 parts, carrageenan 12 16 parts, propolis 12 18 parts, sorbitol 10 14 parts and soybean protein 8 16 parts, temperature rises to 80 90 DEG C, stirs, and eliminates bubble；
6) by step 5) in the raw material for preparing put into and be stained with glue groove, through capsule mould automatic dipping glue, dry, pull out shell；
7) by step 6) in prepare raw material cut according to design size, place into and assembling machine carry out fit, can be prepared by starch hollow capsule.
The invention have the benefit that in the raw material of this starch hollow capsule and have employed Chinese medicine ingredients there is regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, dissipate the health cares such as wind heat clearing away；Under the effect of cooperating of each raw material, this starch hollow capsule mouthfeel is good, nutritious, can provide the nutrition of abundance for human body, enhance metabolism.
Detailed description of the invention
Embodiment 1:
A kind of starch hollow capsule, described raw material is by following parts by weight proportioning composition: starch 18 parts, glycerol 10 parts, chitin 12 parts, acetic acid 14 parts, calcium alginate 16 parts, ethyl cellulose 18 parts, succinic anhydride 10 parts, fresh mushroom polysaccharide 12 parts, guar gum 12 parts, carrageenan 16 parts, propolis 18 parts, sorbitol 14 parts, soybean protein 16 parts, Pericarpium Citri Reticulatae 18 parts and Flos Chrysanthemi 16 parts.
The preparation method of a kind of starch hollow capsule, includes following steps:
1) take starch 18 parts, glycerol 10 parts, chitin 12 parts and acetic acid 14 parts, put in blender, stir；
2) putting in heater by the above-mentioned material stirred, temperature rises to 60 80 DEG C, heats 15 20min, standby；
3) take Pericarpium Citri Reticulatae 18 parts and Flos Chrysanthemi 16 parts is put in jet mill, prepare the powder of 100 130 orders, standby；
4) taking calcium alginate 16 parts, ethyl cellulose 18 parts, succinic anhydride 10 parts and fresh mushroom polysaccharide 12 parts, put in a container, add the deionized water of 0.5 times, temperature rises to 30 50 DEG C, heats while stirring；
5) by step 2) and step 3 in the material for preparing add step 4 to) in, add guar gum 12 parts, carrageenan 16 parts, propolis 18 parts, sorbitol 14 parts and soybean protein 16 parts, temperature rises to 80 90 DEG C, stirs, and eliminates bubble；
6) by step 5) in the raw material for preparing put into and be stained with glue groove, through capsule mould automatic dipping glue, dry, pull out shell；
7) by step 6) in prepare raw material cut according to design size, place into and assembling machine carry out fit, can be prepared by starch hollow capsule.
Embodiment 2:
A kind of starch hollow capsule, described raw material is by following parts by weight proportioning composition: starch 19 parts, glycerol 9 parts, chitin 11 parts, acetic acid 12 parts, calcium alginate 14 parts, ethyl cellulose 14 parts, succinic anhydride 9 parts, fresh mushroom polysaccharide 10 parts, guar gum 11 parts, carrageenan 14 parts, propolis 15 parts, sorbitol 12 parts, soybean protein 12 parts, Pericarpium Citri Reticulatae 15 parts and Flos Chrysanthemi 13 parts.
The preparation method of a kind of starch hollow capsule, includes following steps:
1) take starch 19 parts, glycerol 9 parts, chitin 11 parts and acetic acid 12 parts, put in blender, stir；
2) putting in heater by the above-mentioned material stirred, temperature rises to 60 80 DEG C, heats 15 20min, standby；
3) take Pericarpium Citri Reticulatae 15 parts and Flos Chrysanthemi 13 parts is put in jet mill, prepare the powder of 100 130 orders, standby；
4) taking calcium alginate 14 parts, ethyl cellulose 14 parts, succinic anhydride 9 parts and fresh mushroom polysaccharide 10 parts, put in a container, add the deionized water of 0.5 times, temperature rises to 30 50 DEG C, heats while stirring；
5) by step 2) and step 3 in the material for preparing add step 4 to) in, add guar gum 11 parts, carrageenan 14 parts, propolis 15 parts, sorbitol 12 parts and soybean protein 12 parts, temperature rises to 80 90 DEG C, stirs, and eliminates bubble；
6) by step 5) in the raw material for preparing put into and be stained with glue groove, through capsule mould automatic dipping glue, dry, pull out shell；
7) by step 6) in prepare raw material cut according to design size, place into and assembling machine carry out fit, can be prepared by starch hollow capsule.
Embodiment 3:
A kind of starch hollow capsule, described raw material is by following parts by weight proportioning composition: starch 20 parts, glycerol 8 parts, chitin 10 parts, acetic acid 10 parts, calcium alginate 12 parts, ethyl cellulose 10 parts, succinic anhydride 8 parts, fresh mushroom polysaccharide 8 parts, guar gum 10 parts, carrageenan 12 parts, propolis 12 parts, sorbitol 10 parts, soybean protein 8 parts, Pericarpium Citri Reticulatae 12 parts and Flos Chrysanthemi 10 parts.
The preparation method of a kind of starch hollow capsule, includes following steps:
1) take starch 20 parts, glycerol 8 parts, chitin 10 parts and acetic acid 10 parts, put in blender, stir；
2) putting in heater by the above-mentioned material stirred, temperature rises to 60 80 DEG C, heats 15 20min, standby；
3) take Pericarpium Citri Reticulatae 12 parts and Flos Chrysanthemi 10 parts is put in jet mill, prepare the powder of 100 130 orders, standby；
4) taking calcium alginate 12 parts, ethyl cellulose 10 parts, succinic anhydride 8 parts and fresh mushroom polysaccharide 8 parts, put in a container, add the deionized water of 0.5 times, temperature rises to 30 50 DEG C, heats while stirring；
5) by step 2) and step 3 in the material for preparing add step 4 to) in, add guar gum 10 parts, carrageenan 12 parts, propolis 12 parts, sorbitol 10 parts and soybean protein 8 parts, temperature rises to 80 90 DEG C, stirs, and eliminates bubble；
6) by step 5) in the raw material for preparing put into and be stained with glue groove, through capsule mould automatic dipping glue, dry, pull out shell；
7) by step 6) in prepare raw material cut according to design size, place into and assembling machine carry out fit, can be prepared by starch hollow capsule.
Experimental example:
Experimental subject: select the starch hollow capsule of the present invention and Capsules two kinds common, put into coldrex powder, be respectively divided into experimental group, matched group 1 and matched group 2.
Experimental technique: randomly drawing 150 flu patients, every 50 is one group, takes three groups of Capsuleses respectively.
Experimental result:
As can be seen here, the starch hollow capsule mouthfeel of the present invention is good, nutritious, has health care, can rejuvenate for patient and muscle power, compared with common Capsules, have significant progress.
The invention have the benefit that in the raw material of this starch hollow capsule and have employed Chinese medicine ingredients there is regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, dissipate the health cares such as wind heat clearing away；Under the effect of cooperating of each raw material, this starch hollow capsule mouthfeel is good, nutritious, can provide the nutrition of abundance for human body, enhance metabolism.
Typical case:
Huang has managed a pharmaceutical factory, and Huang plans to make a collection of pharmaceutical capsules, later pharmaceutical capsules added after, through consumer feedback, this pharmaceutical capsules, when taking, mouthfeel is poor, it is difficult to swallow, after Huang learns situation, the Capsules of this medicine being used the starch hollow capsule of the present invention, later consumer feedback instead, when this pharmaceutical capsules of starch hollow capsule that have employed the present invention is taken, mouthfeel is good, taking rear vigor and muscle power all improves, pharmaceutical factory's development of Huang is also become better and better.
The above, be only the specific embodiment of the present invention, but protection scope of the present invention be not limited thereto, any change expected without creative work or replacement, all should be encompassed in protection scope of the present invention.
Claims (5)
1. starch hollow capsule and preparation method thereof, it is characterised in that: it is made up of following raw material: starch, glycerol, chitin, acetic acid, calcium alginate, ethyl cellulose, succinic anhydride, fresh mushroom polysaccharide, guar gum, carrageenan, propolis, sorbitol, soybean protein, Pericarpium Citri Reticulatae and Flos Chrysanthemi；Described raw material is by following parts by weight proportioning composition: starch 18 20 parts, glycerol 8 10 parts, chitin 10 12 parts, acetic acid 10 14 parts, calcium alginate 12 16 parts, ethyl cellulose 10 18 parts, succinic anhydride 8 10 parts, fresh mushroom polysaccharide 8 12 parts, guar gum 10 12 parts, carrageenan 12 16 parts, propolis 12 18 parts, sorbitol 10 14 parts, soybean protein 8 16 parts, Pericarpium Citri Reticulatae 12 18 parts and Flos Chrysanthemi 10 16 parts.
2. starch hollow capsule as claimed in claim 2 and preparation method thereof, it is characterised in that: described raw material is by following parts by weight proportioning composition: starch 18 parts, glycerol 10 parts, chitin 12 parts, acetic acid 14 parts, calcium alginate 16 parts, ethyl cellulose 18 parts, succinic anhydride 10 parts, fresh mushroom polysaccharide 12 parts, guar gum 12 parts, carrageenan 16 parts, propolis 18 parts, sorbitol 14 parts, soybean protein 16 parts, Pericarpium Citri Reticulatae 18 parts and Flos Chrysanthemi 16 parts.
3. starch hollow capsule as claimed in claim 3 and preparation method thereof, it is characterised in that: described raw material is by following parts by weight proportioning composition: starch 19 parts, glycerol 9 parts, chitin 11 parts, acetic acid 12 parts, calcium alginate 14 parts, ethyl cellulose 14 parts, succinic anhydride 9 parts, fresh mushroom polysaccharide 10 parts, guar gum 11 parts, carrageenan 14 parts, propolis 15 parts, sorbitol 12 parts, soybean protein 12 parts, Pericarpium Citri Reticulatae 15 parts and Flos Chrysanthemi 13 parts.
4. starch hollow capsule as claimed in claim 4 and preparation method thereof, it is characterised in that: described raw material is by following parts by weight proportioning composition: starch 20 parts, glycerol 8 parts, chitin 10 parts, acetic acid 10 parts, calcium alginate 12 parts, ethyl cellulose 10 parts, succinic anhydride 8 parts, fresh mushroom polysaccharide 8 parts, guar gum 10 parts, carrageenan 12 parts, propolis 12 parts, sorbitol 10 parts, soybean protein 8 parts, Pericarpium Citri Reticulatae 12 parts and Flos Chrysanthemi 10 parts.
5. the preparation method of a starch hollow capsule, it is characterised in that: include following steps:
1) take starch 18 20 parts, glycerol 8 10 parts, chitin 10 12 parts and acetic acid 10 14 parts, put in blender, stir；
2) putting in heater by the above-mentioned material stirred, temperature rises to 60 80 DEG C, heats 15 20min, standby；
3) take Pericarpium Citri Reticulatae 12 18 parts and Flos Chrysanthemi 10 16 parts is put in jet mill, prepare the powder of 100 130 orders, standby；
4) taking calcium alginate 12 16 parts, ethyl cellulose 10 18 parts, succinic anhydride 8 10 parts and fresh mushroom polysaccharide 8 12 parts, put in a container, add the deionized water of 0.5 times, temperature rises to 30 50 DEG C, heats while stirring；
5) by step 2) and step 3 in prepare material add step 4 to) in, add guar gum 10 12 parts, carrageenan 12 16 parts, propolis 12 18 parts, sorbitol 10 14 parts and soybean protein 8 16 parts, temperature rises to 80 90 DEG C, stirs, and eliminates bubble；
6) by step 5) in the raw material for preparing put into and be stained with glue groove, through capsule mould automatic dipping glue, dry, pull out shell；
7) by step 6) in prepare raw material cut according to design size, place into and assembling machine carry out fit, can be prepared by starch hollow capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610293020.1A CN105769811A (en) | 2016-05-05 | 2016-05-05 | Empty starch capsule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610293020.1A CN105769811A (en) | 2016-05-05 | 2016-05-05 | Empty starch capsule and preparation method thereof |
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| CN105769811A true CN105769811A (en) | 2016-07-20 |
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| CN201610293020.1A Withdrawn CN105769811A (en) | 2016-05-05 | 2016-05-05 | Empty starch capsule and preparation method thereof |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1687203A (en) * | 2005-04-07 | 2005-10-26 | 天津大学 | Vegetable capsule of starch composition and preparation method |
| CN103083676A (en) * | 2011-11-02 | 2013-05-08 | 赵迪 | Hollow hard capsules |
| CN103830737A (en) * | 2014-03-13 | 2014-06-04 | 中国科学院化学研究所 | Functionalized starch matrix hollow capsule |
| CN104107174A (en) * | 2014-07-08 | 2014-10-22 | 浙江越溪胶丸有限公司 | Health hollow capsule |
| CN104127877A (en) * | 2014-07-29 | 2014-11-05 | 浙江益立胶囊有限公司 | Plant hollow capsule |
| CN104434871A (en) * | 2014-10-27 | 2015-03-25 | 绍兴康可胶囊有限公司 | Enteric-coated plant empty capsules and preparation method thereof |
| CN104706617A (en) * | 2013-12-16 | 2015-06-17 | 深圳市伟崇科技发展有限公司 | Vegetable protein hollow capsule preparation method |
| CN104800189A (en) * | 2015-05-13 | 2015-07-29 | 湖南尔康制药股份有限公司 | Starch plant hollow capsule |
-
2016
- 2016-05-05 CN CN201610293020.1A patent/CN105769811A/en not_active Withdrawn
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1687203A (en) * | 2005-04-07 | 2005-10-26 | 天津大学 | Vegetable capsule of starch composition and preparation method |
| CN103083676A (en) * | 2011-11-02 | 2013-05-08 | 赵迪 | Hollow hard capsules |
| CN104706617A (en) * | 2013-12-16 | 2015-06-17 | 深圳市伟崇科技发展有限公司 | Vegetable protein hollow capsule preparation method |
| CN103830737A (en) * | 2014-03-13 | 2014-06-04 | 中国科学院化学研究所 | Functionalized starch matrix hollow capsule |
| CN104107174A (en) * | 2014-07-08 | 2014-10-22 | 浙江越溪胶丸有限公司 | Health hollow capsule |
| CN104127877A (en) * | 2014-07-29 | 2014-11-05 | 浙江益立胶囊有限公司 | Plant hollow capsule |
| CN104434871A (en) * | 2014-10-27 | 2015-03-25 | 绍兴康可胶囊有限公司 | Enteric-coated plant empty capsules and preparation method thereof |
| CN104800189A (en) * | 2015-05-13 | 2015-07-29 | 湖南尔康制药股份有限公司 | Starch plant hollow capsule |
Non-Patent Citations (2)
| Title |
|---|
| 刘李梅等: "植物空心胶囊的研究进展", 《中药与临床》 * |
| 姚静: "《药用辅料应用指南》", 31 August 2011, 北京：中国医药科技出版社 * |
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Application publication date: 20160720 |