CN105767535A - Feed additive for livestocks - Google Patents
Feed additive for livestocks Download PDFInfo
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- CN105767535A CN105767535A CN201610154778.7A CN201610154778A CN105767535A CN 105767535 A CN105767535 A CN 105767535A CN 201610154778 A CN201610154778 A CN 201610154778A CN 105767535 A CN105767535 A CN 105767535A
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- feed additive
- quinocetone
- herba origani
- animals
- origani oil
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Abstract
The invention provides a feed additive for livestock. The feed additive is prepared from the following compositions and main active components of quinocetone, cretian origanum oil and suitable pharmaceutic adjuvants. Pharmacy tests prove that according to a medicine namely the feed additive, the quinocetone and the cretian origanum oil are in compatibility for use, under a specific compounding ratio, the feed additive has a synergistic interaction, and also has the effects of promoting growth of livestock and poultry, increasing the feed conversion ratio, preventing the livestock and the poultry from suffering from diarrhoea and the like.
Description
Technical field
The present invention relates to a kind of veterinary medical composition, particularly relate to a kind of feed additive for animals.
Background technology
Along with the development of science and technology, scientific culture is increasingly focused in cultivation, under ensureing healthy aquaculture premise, improves animal disease resistant power by adding some medicines, promotes growth of animal, reduce feedstuff-meat ratio, improve food conversion ratio, and becomes modern cultivation conventional means.With regard to being used in prior art treating raising animal disease resistant power, promoting that growth of animal medicine or compositions vary, effect is not quite similar.
This seminar finds that quinocetone and Herba Origani oil combination can remarkably promote growth of animal, reduces feedstuff-meat ratio, improves animal disease resistant power, prevents and treats livestock and poultry diarrhea.
Summary of the invention
The technical scheme is that and provide a kind of feed additive for animals, main active includes quinocetone, Herba Origani oil.
Further, a kind of feed additive for animals, count by weight percentage, quinocetone is 4～20%, Herba Origani oil is 1～10%.
A kind of feed additive for animals, it can pass through to add suitable adjuvant preparation is solid preparation and pharmaceutical solutions, and described solid preparation includes pre-mixing agent, granule, tablet, microcapsule formulation, and described pharmaceutical solutions includes oral liquid, Emulsion.
Beneficial effect
Quinocetone (enramycin) is to be obtained by actinomycetes (Streptomycesfungicidicus) fermentation, it is unsaturated fatty acid and the polypeptide antibiotics of tens seed amino acids combination, key component has quinocetone A and B, it is white or yellowish white powder (powder of crude product gray or taupe, have special smell).Gram positive bacteria is had very strong activity by quinocetone, particularly that harmful clostridium (Clostridium) restraint of enteral is very strong.Being not easy after life-time service to develop immunity to drugs, have the bacterial flora effect changed in intestinal, poultry add use for a long time, it is possible to promote pig, chicken weightening finish and improve food conversion ratio.
Herba Origani oil is again dysentery relieving grass, is the volatile essential oils extracted from plant Adeps Bovis seu Bubali, and it has volatility and the distinctive zest taste of Adeps Bovis seu Bubali.Herba Origani oil is a kind of broad spectrum antimicrobicide, and it is to G+Bacterium and G-Bacterium is respectively provided with height antibacterial activity, and the multiple virus of poultry body and fungus are also had certain killing action, to gut bacteria disease as diarrhoea, feedstuff just etc. have specially good effect, secondly Herba Origani oil also has antagonism dysentery Plasmodium falciparum activity, anticoccidial and antimite activity, the activity of digestive enzyme can be improved, improve food conversion ratio, " Herba Origani oil impact on Intestine of Broiler microorganism species " article shows, Herba Origani oil can improve Intestine of Broiler microbial bacteria group structure, promotes that bacillus bifidus and lactobacillus quantity increase and suppresses escherichia coli quantity.
Pharmacodynamics test proves, quinocetone and Herba Origani oil compatibility are used by the present invention, under specific proportioning, there is the effect of Synergistic, have and remarkably promote growth of animal, reduce feedstuff-meat ratio, improve the effect of animal disease resistant power, and have remarkable result to preventing and treating animal diarrhea disease.
Detailed description of the invention
In order to make those skilled in the art be better understood from technical scheme, below in conjunction with detailed description of the invention, technical scheme of the present invention is described in further detail.
Embodiment 1: pre-mixing agent
Accurately weigh by weight percentage: quinocetone 4%, Herba Origani oil 1%, the auxiliary U.S. powder polishing of surplus, mix homogeneously, prepare into pre-mixing agent.
Embodiment 2: granule
Accurately weigh by weight percentage: quinocetone 8%, Herba Origani oil 5%, sodium carboxymethyl cellulose 2%, water 10%, starch polishing, granulate by one-step method.
Embodiment 3: tablet
Accurately weigh by weight percentage: quinocetone 10%, Herba Origani oil 10%, gumwater 10%, dried starch 2%, mannitol polishing, wet granule compression tablet.
Embodiment 4: oral liquid
Accurately weighing by weight percentage: quinocetone 15%, Herba Origani oil 2.5%, glycerol 20%, dehydrated alcohol polishing, regulate ph, stirring makes each composition dissolve completely to settled solution.
Embodiment 5: Emulsion
Accurately weighing by weight percentage: quinocetone 20%, Herba Origani oil 6%, add in 58% ethyl oleate after Homogeneous phase mixing, add 2% tween 80, surplus adds water, high pressure homogenizer emulsifying.
Adopting requirement and method detection above-mentioned pre-mixing agent, granule, oral liquid, the Emulsion of " Chinese veterinary pharmacopoeia ", indices all meets regulation.
Below by way of test, effect of the present invention is further explained.
Test 1: the therapeutic effect of piglet diarrhea is observed by embodiment 1
1. select Experimental agents: pre-mixing agent described in the embodiment of the present invention 1.
2. animal subject: according to clinical experience, selects the doubtful animal suffering from piglet epidemic diarrhea respectively in different breeding field；
3. method: infected animal is randomly divided into four groups, respectively:
(1) blank group: do not carry out any process；
(2) experimental group: adopt pre-mixing agent described in the mixed feeding embodiment of the present invention 1,250g/ ton feedstuff, be used in conjunction 7 days.
(3) quinocetone matched group: adopt 4% quinocetone premix that mixed feeding Shanghai animal pharmaceutical factory produces, 250g/ ton feedstuff, be used in conjunction 7 days.
(4) Herba Origani oil matched group: adopt mixed feeding self-control Herba Origani oil pre-mixing agent (the auxiliary U.S. powder polishing of Herba Origani oil 1%+), 250g/ ton feedstuff, be used in conjunction 7 days.
The clinical sign of also recording laboratory animal is observed, it is judged that therapeutic effect in seven days.
4. index of assessment of curative effect
It is cure that cure rate: clinical symptoms is wholly absent after medication is treated, spirit and diet recover normal, and statistics cures number, calculates cure rate.
Effective percentage: animal and the symptom cured after medication is treated have and substantially alleviate this, are all judged to effectively.
Inefficiency: after medication is treated clinical symptoms do not disappear, the state of an illness do not take a turn for the better and treat during because of primary disease dead be accordingly to be regarded as invalid, add up invalid number, calculate inefficiency.
5. the statistical disposition biometrics of data carries out the significance test of data, embodiment 1 experimental result such as table 1 below:
Table 1 embodiment of the present invention 1 therapeutic effect to piglet diarrhea
| Group | Case load | Cure rate (%) | Effective percentage (%) | Inefficiency (%) |
| Experimental group | 300 | 70% a | 16.7% a | 13.3% c |
| Quinocetone matched group | 300 | 25.3% b | 45% b | 29.7% b |
| Herba Origani oil matched group | 300 | 21.7% b | 40.3% b | 38% b |
| Blank group | 300 | 0% c | 8.3% c | 91.7% a |
Note: represent difference not notable (P > 0.05) with column data shoulder mark same letter;The different letter representation significant difference (P < 0.05) of shoulder mark.
As seen from the above table, treatment cure rate and the effective percentage of piglet diarrhea are all remarkably higher than quinocetone matched group and Herba Origani oil matched group and blank group by the embodiment of the present invention 1, and inefficiency is substantially less than other three groups.It is shown that the present invention can effectively treat piglet diarrhea.
Test 2: the impact of Growth Performance of Weaning Piglets is tested by the embodiment of the present invention 5
Trial drug: the embodiment of the present invention 5, by Herba Origani oil Emulsion prepared by embodiment 5 method, by quinocetone Emulsion prepared by embodiment 5 method.
Experimental animal and packet: choose (20 ± 2) age in days, the close length of body weight is white × DABAI two-way cross ablactational baby pig 96, male and female half and half, it is randomly divided into 4 groups, often group 24, each 2 repetitions, each repetition 12.Test 1～3 is test group, tests 4 groups for blank group.
EXPERIMENTAL DESIGN:
Testing 1 group, test group, every 100 kg of water add the Emulsion 50g prepared by the embodiment of the present invention 5, freely drink, are used in conjunction 30d；
Testing 2 groups, Herba Origani oil matched group, every 100 kilograms are added Herba Origani oil Emulsion (Herba Origani oil 6%+58% ethyl oleate+2% tween 80+water polishing) 50g prepared by embodiment 5 method, freely drink, be used in conjunction 30d；
Testing 3 groups, quinocetone matched group, every 100 kilograms are added quinocetone Emulsion (quinocetone 20%+58% ethyl oleate+2% tween 80+water polishing) 50g prepared by embodiment 5 method, freely drink, be used in conjunction 30d.
Test 4 groups, blank group, normally feed, without other drug.
Test method: weigh on an empty stomach respectively at formal test the 1st day, the 31st day early morning, the body weight of record often group test piglet and health status.During test, allow piglet free choice feeding every day, record the feed intake of each group；It is recorded for often organizing incidence during test, and does the timely process of necessity.
Result of the test: see table 2 below.
Table 2: Growth Performance of Weaning Piglets is affected result of the test by the embodiment of the present invention 5
| Group | Average daily gain/kg | Feed-weight ratio |
| Test 1 group (test group) | 0.62 | 1.16 |
| Test 2 groups (Herba Origani oil matched groups) | 0.53 | 1.43 |
| Test 3 groups (quinocetone matched groups) | 0.50 | 1.36 |
| Blank group | 0.32 | 1.88 |
As shown in Table 2, testing 1 group of piglet within the experimental period of 30 days, its average daily gain is all remarkably higher than other 3 groups, and feed-weight ratio is all substantially less than other 3 groups, illustrates that the interpolation of embodiment 5 medicine can remarkably promote the growth of piglet.
Claims (5)
1. a feed additive for animals, it is characterised in that: main active includes quinocetone, Herba Origani oil.
2. one according to claim 1 feed additive for animals, it is characterised in that: counting by weight percentage, quinocetone is 5～50%, Herba Origani oil is 1～10%.
3. the one feed additive for animals according to any one of claim 1～2, it is characterised in that: it can pass through to add suitable adjuvant preparation is solid preparation and pharmaceutical solutions.
4. one according to claim 3 feed additive for animals, it is characterised in that: described solid preparation includes pre-mixing agent, granule, tablet.
5. one according to claim 3 feed additive for animals, it is characterised in that: described pharmaceutical solutions includes oral liquid, Emulsion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610154778.7A CN105767535A (en) | 2016-03-18 | 2016-03-18 | Feed additive for livestocks |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610154778.7A CN105767535A (en) | 2016-03-18 | 2016-03-18 | Feed additive for livestocks |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105767535A true CN105767535A (en) | 2016-07-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610154778.7A Pending CN105767535A (en) | 2016-03-18 | 2016-03-18 | Feed additive for livestocks |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101244184A (en) * | 2007-04-11 | 2008-08-20 | 北京龙科方舟生物工程技术中心 | Enteron modifying agent, preparation method and application thereof |
| CN102630856A (en) * | 2012-05-17 | 2012-08-15 | 山东新希望六和集团有限公司 | Compound feed additive capable of lowering diarrhea and promoting growth of weaned pig |
| CN103504138A (en) * | 2012-06-21 | 2014-01-15 | 欧佐文 | Piglet feed additive |
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2016
- 2016-03-18 CN CN201610154778.7A patent/CN105767535A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101244184A (en) * | 2007-04-11 | 2008-08-20 | 北京龙科方舟生物工程技术中心 | Enteron modifying agent, preparation method and application thereof |
| CN102630856A (en) * | 2012-05-17 | 2012-08-15 | 山东新希望六和集团有限公司 | Compound feed additive capable of lowering diarrhea and promoting growth of weaned pig |
| CN103504138A (en) * | 2012-06-21 | 2014-01-15 | 欧佐文 | Piglet feed additive |
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Application publication date: 20160720 |