CN105766919A - Bactericidal composition containing triflumizole and (E)2-[2-(2, 5-dimethylphenoxytoluene)-phenyl]-3-methoxyacrylate - Google Patents
Bactericidal composition containing triflumizole and (E)2-[2-(2, 5-dimethylphenoxytoluene)-phenyl]-3-methoxyacrylate Download PDFInfo
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- CN105766919A CN105766919A CN201610261471.7A CN201610261471A CN105766919A CN 105766919 A CN105766919 A CN 105766919A CN 201610261471 A CN201610261471 A CN 201610261471A CN 105766919 A CN105766919 A CN 105766919A
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- bacterium azoles
- fluorine bacterium
- bactericidal composition
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- dimethylphenoxytoluene
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
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- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericidal composition containing triflumizole and (E)2-[2-(2, 5-dimethylphenoxytoluene)-phenyl]-3-methoxyacrylate. The bactericidal composition comprises the following active ingredients: triflumizole and (E)2-[2-(2, 5-dimethylphenoxytoluene)-phenyl]-3-methoxyacrylate at the weight ratio of 1:10 to 10:1; the total weight of triflumizole and (E)2-[2-(2, 5-dimethylphenoxytoluene)-phenyl]-3-methoxyacrylate accounts for 5-85 percent by weight of the composition. According to practical application needs, the bactericidal composition provided by the invention can be prepared into one of suspension, microcapsule suspension, water emulsion, micro-emulsion, ultra-low volume liquid, wettable powder and water dispersible granule, and is used to prevent and control the powdery mildew of cucumber.
Description
Technical field
The present invention relates to a kind of bactericidal composition containing fluorine bacterium azoles and ZJ0712, be with fluorine bacterium azoles and ZJ0712 for effective ingredient, be used for preventing and treating powdery mildew of cucumber.
Background technology
The resistance problem of agricultural disease is a global problem, is always up the emphasis problem that agricultural science and technology worker pays close attention to.Along with the continuity year in year out of disease chemical prevention, the increase of Pesticide use amount and not scientifical use pesticide, pathogenic bacteria resistance is day by day serious, and the pathogenic bacteria kind producing resistance is on the increase.Meanwhile, the use pesticide of high intensity, cause Practice for Pesticide Residue in Agricultural Products to exceed standard, environmental pollution and peasant's drug cost increase etc., be unfavorable for agricultural sustainable development.Therefore, research and development efficiently, low toxicity, environmental protection bactericide agricultural chemicals agricultural sustainable development is had positive effect.
Fluorine bacterium azoles, chemical name: (E)-4-chloro-α, α, α-three fluoro-N-(1-imidazoles-1-base-α the-the third oxygen ethylidene) o-toluidines fluorine bacterium azoles;Fluorine bacterium azoles is imidazoles antibacterial, and the mechanism of action is by suppressing sterol demethylation, has protection, treatment and systemic action, to the microbial powdery mildew specially good effect of ascus.
ZJ0712, chemical name: (E) 2-[2-(2,5-dimethyl phenoxy toluene)-phenyl]-3-methoxy-methyl acrylate;ZJ0712 is methoxy acrylic bactericide, fungicidal spectrum is wide, bactericidal activity is high, instant effect, and resistance of rainwater washing against, lasting period are long, the powdery mildew (such as cucurbits powdery mildew, apple mildew etc.) of various crops, rust (such as rust of apple (Gymnosporangium yamadai), rust of pear etc.), downy mildew (downy mildew of garpe, cucumber downy mildew etc.), anthrax (such as Fructus Cucumidis sativi, Citrullus vulgaris and mango anthracnose etc.) are all shown excellent prevention effect, it is achieved that spray a kind of antibacterial and can control crop mixes the multiple diseases of generation simultaneously.
The mixture of different pesticide species, is the common methods of preventing and treating agricultural pest.Screened by formulation of pesticide, filter out rational formula, actual prevention effect can be effectively improved, reduce dosage, reduce cost, delay the drug-fast generation of pest and disease damage, be the important means of agricultural synthesis improvement.The recipe determination of fluorine bacterium azoles and ZJ0712 is conducted in-depth research by the present inventor, it has been found that fluorine bacterium azoles and ZJ0712 carry out mixture has obvious potentiation in certain mixed ratio scope to multiple fungus, after further study, completes the present invention.
Compositions and the application of fluorine bacterium azoles and ZJ0712 there is no report at present.
Summary of the invention
Present invention solves the technical problem that the bactericidal composition containing fluorine bacterium azoles and ZJ0712 being to provide a kind of efficient, low toxicity and lasting period length, can effectively prevent and treat agricultural fungal evil.
For solving the problems referred to above, the technical solution adopted in the present invention is: a kind of bactericidal composition containing fluorine bacterium azoles and ZJ0712, effective ingredient is fluorine bacterium azoles and ZJ0712, the weight ratio of fluorine bacterium azoles and ZJ0712 is 1:10~10:1, fluorine bacterium azoles and ZJ0712 weight summation percentage by weight in the composition are 5%~85%, and all the other are agriculturally allow to use and acceptable pesticidal preparations auxiliary element.
A kind of bactericidal composition containing fluorine bacterium azoles and ZJ0712 of the present invention according to well known to a person skilled in the art method, can be configured to the one in suspending agent, micro-capsule suspension, aqueous emulsion, microemulsion, ultra low volume liquids, wettable powder, water dispersible granules.
A kind of bactericidal composition containing fluorine bacterium azoles and ZJ0712 of the present invention is possibly together with the auxiliary agent needed for preparation pesticidal preparations, auxiliary agent is the mixing of one or more in solvent, emulsifying agent, wetting agent, stabilizer, dispersant, thickening agent, pH adjusting agent, defoamer, antifreezing agent, packing agent etc., it is known substance, it is various auxiliary agents conventional in pesticidal preparations, can be varied from according to different situations, be not particularly limited.
A kind of bactericidal composition containing fluorine bacterium azoles and ZJ0712 of the present invention, is used for preventing and treating powdery mildew of cucumber.
A kind of bactericidal composition containing fluorine bacterium azoles and ZJ0712 provided by the invention, generally adopts spray method to use, it is also possible to adopt other use technology agriculturally applied as required.
One provided by the invention contains fluorine bacterium azoles and ZJ0712 compositions has the advantages that:
1, bactericidal composition provided by the invention, obvious potentiation or summation action is shown in certain ratio range, the prevention effect of pathogenic bacteria is significantly improved by compositions than single dose, reduce the using dosage of pesticide, decrease times for spraying, reduce drug cost, decrease the pesticide adverse effect to ecological environment.
2, bactericidal composition provided by the invention, two kinds of effective ingredient mechanism of action are not quite identical, it is possible to overcome long-term single use easily to produce the shortcoming of resistance, extend the service life of medicament, the comprehensive control important in inhibiting to pathogenic bacteria resistance.
3, bactericidal composition provided by the invention, drug effect plays rapidly, and the lasting period is long, and use cost is low, easy to use, time saving and energy saving, and its popularization and application have huge economic benefit and social benefit.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage more short and sweet, present invention specific examples below illustrates, but the present invention is only limitted to absolutely not these embodiments.The following stated is only the good embodiment of the present invention, is used only for describing the present invention, it is impossible to be interpreted as the restriction to the scope of the present invention.It should be pointed out that, all any amendment, equivalent replacement and improvement etc. made within the spirit and principles in the present invention, should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Content described in embodiment is all weight percentage.
Embodiment 1:33% fluorine bacterium azoles ZJ0712 suspending agent
First being mixed by other auxiliary agent, in cutter, shear-mixed is uniform, is subsequently adding fluorine bacterium azoles and ZJ0712, grinds 2-3h, make a diameter all at below 5mm, can be prepared by 33% fluorine bacterium azoles ZJ0712 suspending agent in ball crusher.
Embodiment 2:15% fluorine bacterium azoles ZJ0712 aqueous emulsion
First fluorine bacterium azoles and ZJ0712, trimethylbenzene, Sorbitan fatty acid ester are mixed, dissolve and become uniform oil phase.Again part water and other auxiliary agents are mixed, dissolve and become uniform aqueous phase.Then oil phase is added aqueous phase while high-speed stirred in a kettle., slowly add water to and reach phase inversion point, carry out high speed shear afterwards, and add remaining water, shear about 30min, can be prepared by 15% fluorine bacterium azoles ZJ0712 aqueous emulsion.
Embodiment 3:28% fluorine bacterium azoles ZJ0712 microemulsion
First fluorine bacterium azoles and ZJ0712 fatty acid methyl ester are completely dissolved, then add other auxiliary agent, mix homogeneously, be eventually adding water, after being sufficiently stirred for, can be prepared by 28% fluorine bacterium azoles ZJ0712 microemulsion.
Embodiment 4:40% fluorine bacterium azoles ZJ0712 wettable powder
Fluorine bacterium azoles and ZJ0712, other auxiliary agent are sufficiently stirred in stirred tank, mix homogeneously after jet mill is pulverized, can be prepared by 40% fluorine bacterium azoles ZJ0712 wettable powder.
Embodiment 5:20% fluorine bacterium azoles ZJ0712 water dispersible granules
To there be fluorine bacterium azoles and ZJ0712, other auxiliary agent mix homogeneously, pulverize with micro jet, and add in fluidized-bed granulation dryer after mediating after carrying out pelletize, dry, screening, can be prepared by 20% fluorine bacterium azoles ZJ0712 water dispersible granules.
Embodiment 6:24% fluorine bacterium azoles ZJ0712 micro-capsule suspension
By fluorine bacterium azoles and ZJ0712, macromolecule cyst material, solvent mixing, make to be dissolved into homogeneous oil phase, in a shear condition, oil phase is joined containing emulsifying agent, dispersant aqueous phase solution in, adding mannitol and regulate pH value to 6.5, surplus deionized water is supplied, and bi-material reacts at oil-water interfaces, form macromolecule cyst wall, can be prepared by 24% fluorine bacterium azoles ZJ0712 micro-capsule suspension.
Embodiment 7:11% fluorine bacterium azoles ZJ0712 ultra low volume liquids
After fluorine bacterium azoles and ZJ0712 are dissolved by stirring solvent, add other auxiliary agent, be sufficiently stirred for mix homogeneously, can be prepared by 11% fluorine bacterium azoles ZJ0712 ultra low volume liquids.
Embodiment 8: synergy measurement result
Powdery mildew of cucumber test adopts field spray method dispenser (having water membrane to be advisable with blade surface), spraying process is carried out on June 11st, 2015, medicinal sprayer tool adopts hand sprayer (liquid capacity is about 2.0L), sprays medicine once every 10 days, continuously spray 2 times.
Investigation method:
0 grade: without scab;
1 grade: lesion area accounts for less than the 5% of whole leaf area;
3 grades: lesion area accounts for the 6%-15% of whole leaf area;
5 grades: lesion area accounts for the 16%-25% of whole leaf area;
7 grades: lesion area accounts for the 26%-50% of whole leaf area;
9 grades: lesion area accounts for more than the 50% of whole leaf area.
According to survey data, calculate disease index and the prevention effect of each process.
Disease index is pressed formula and is calculated, and result of calculation retains 2 significant digits:
When carrying out drug combination toxicity test, this test adopts Wadley method to calculate the coefficient of synergism (SR) of mixture, evaluates the synergy type of mixture.
Wadley method: evaluate the potentiation of pharmacy mix according to coefficient of synergism (SR), namely SR<0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR>1.5 is synergistic function.Coefficient of synergism (SR) calculates by formula (1), (2):
In formula:
X1--mixture EC50Theoretical value, unit is milligrams per liter (mg/L);
PA--the percentage composition of A in mixture, unit is percentage rate (%);
PB--the percentage composition of B in mixture, unit is percentage rate (%);
The EC of A in A--mixture50Value, unit is milligrams per liter (mg/L);
The EC of B in B--mixture50Value, unit is milligrams per liter (mg/L).
In formula:
The coefficient of synergism of S--mixture;
The EC of X1--mixture50Theoretical value, unit is milligrams per liter (mg/L);
The EC of X2--mixture50Measured value, unit is milligrams per liter (mg/L).
Table 1, fluorine bacterium azoles and the ZJ0712 synergy measurement result to powdery mildew of cucumber pathogenic bacteria
As can be seen from Table 1, fluorine bacterium azoles is composite in the scope of 1:10-10:1 with ZJ0712, and powdery mildew of cucumber is shown as potentiation.
Embodiment 9: prevent and treat powdery mildew of cucumber field test
Test site is positioned at Compounds in Dongfang City of Hainan Province, adopts nebulization.Adopt 30% triflumizole wettable powder, 10% ZJ0712 suspending agent as comparison medicament, test sets 9 chemicals treatment altogether, each process repeats for 4 times, Fructus Cucumidis sativi diseased plant number is investigated before dispenser, within after dispenser 7 days, 15 days, respectively investigate a prevention effect, record diseased plant number, calculates prevention effect, and result of the test is as shown in table 2.
Table 2, fluorine bacterium azoles and ZJ0712 combination prevent and treat powdery mildew of cucumber field test results
As can be seen from Table 2, the effect of bactericidal composition of the present invention preventing and treating is better than each comparison single dose and processes, and fluorine bacterium azoles is described and ZJ0712 is composite can improve prevention effect, reduce the using dosage of pesticide, decrease the pesticide impact on environment, reduce drug cost.
Claims (3)
1. the bactericidal composition containing fluorine bacterium azoles and ZJ0712, it is characterized in that: effective ingredient is fluorine bacterium azoles and ZJ0712, the weight ratio of fluorine bacterium azoles and ZJ0712 is 1:10~10:1, and fluorine bacterium azoles and ZJ0712 weight summation percentage by weight in the composition are 5%~85%.
2. a kind of bactericidal composition containing fluorine bacterium azoles and ZJ0712 according to claim 1, it is characterised in that: the dosage form of described bactericidal composition is the one of suspending agent, micro-capsule suspension, aqueous emulsion, microemulsion, ultra low volume liquids, wettable powder, water dispersible granules.
3. a kind of bactericidal composition containing fluorine bacterium azoles and ZJ0712 described in claim 1 is preventing and treating the application of powdery mildew of cucumber.
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CN201610261471.7A CN105766919A (en) | 2016-04-22 | 2016-04-22 | Bactericidal composition containing triflumizole and (E)2-[2-(2, 5-dimethylphenoxytoluene)-phenyl]-3-methoxyacrylate |
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CN201610261471.7A CN105766919A (en) | 2016-04-22 | 2016-04-22 | Bactericidal composition containing triflumizole and (E)2-[2-(2, 5-dimethylphenoxytoluene)-phenyl]-3-methoxyacrylate |
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Cited By (1)
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CN108064854A (en) * | 2016-11-11 | 2018-05-25 | 华中师范大学 | A kind of composition pesticide and its application containing benzothiostrobin and fluorine bacterium azoles |
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CN1456054A (en) * | 2003-03-25 | 2003-11-19 | 浙江省化工研究院 | Methoxy methyl acrylate compounds as bactericidal agent |
CN101400259A (en) * | 2006-03-14 | 2009-04-01 | 巴斯夫欧洲公司 | Method of inducing tolerance of plants against bacterioses |
CN101578985A (en) * | 2009-05-25 | 2009-11-18 | 陕西韦尔奇作物保护有限公司 | Sterilization composition containing kresoxim-methyl and triflumizole |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1456054A (en) * | 2003-03-25 | 2003-11-19 | 浙江省化工研究院 | Methoxy methyl acrylate compounds as bactericidal agent |
CN101400259A (en) * | 2006-03-14 | 2009-04-01 | 巴斯夫欧洲公司 | Method of inducing tolerance of plants against bacterioses |
CN101578985A (en) * | 2009-05-25 | 2009-11-18 | 陕西韦尔奇作物保护有限公司 | Sterilization composition containing kresoxim-methyl and triflumizole |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN108064854A (en) * | 2016-11-11 | 2018-05-25 | 华中师范大学 | A kind of composition pesticide and its application containing benzothiostrobin and fluorine bacterium azoles |
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