CN105766896B - A kind of dispersible oil-suspending agent - Google Patents
A kind of dispersible oil-suspending agent Download PDFInfo
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- CN105766896B CN105766896B CN201410828924.0A CN201410828924A CN105766896B CN 105766896 B CN105766896 B CN 105766896B CN 201410828924 A CN201410828924 A CN 201410828924A CN 105766896 B CN105766896 B CN 105766896B
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- mesotrione
- suspending agent
- dispersible oil
- stabilizer
- oil
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Abstract
The invention belongs to technical field of pesticide, particularly relate to a kind of dispersible oil-suspending agent containing mesotrione.Contain mesotrione, and add in stabilizer in dispersible oil-suspending agent active component；Wherein, stabilizer addition accounts for 0.1 5wt% of dispersible oil-suspending agent system.The dispersible oil-suspending agent of present invention addition stabilizer can reduce decomposition of the mesotrione in oils decentralized medium, can guarantee the relative rate of resolution of mesotrione below 5% in heat storage stability experiment；The color of formulation aesthetics can especially be prevented, which to increase, deeply, makes the dispersible oil-suspending agent formulation products containing mesotrione in the stable state stored with mesotrione is kept in transportational process；Stabilizer of the present invention is good to the adaptability of former pharmaceutical formulation, and the dispersible oil-suspending agent of mixture of other compositions is either still compounded to the dispersible oil-suspending agent of mesotrione single dose, and being showed no influences the original physical and chemical performance of preparation.
Description
Technical field
The invention belongs to technical field of pesticide, particularly relate to a kind of dispersible oil-suspending agent containing mesotrione.
Background technology
Mesotrione also known as " mesotrione " are that one kind can inhibit medical midbodies of para (ortho)-hydroxybenzoic acetone acid esters dual oxide enzyme (HPPD)
Bud before and seedling after wide spectrum selective herbicide, can effectively prevent main broadleaved herb and some grassy weeds.Mesotrione
It is easily conducted in plant xylem and bast, there is action of contace poison and wholesomeness.
The development of dispersible oil-suspending agent starts from the later stage seventies, just gradually grows up to the eighties.Due to water baseization,
Spheroidizing application effect of products particularly drug effect still has a certain distance compared with cream preparation in many cases, in certain feelings
Dispersible oil-suspending agent is an ideal selection mode under condition.
Mesotrione is prepared into dispersible oil-suspending agent, by the use of oils decentralized medium and suitable for oil base body
It is the addition of auxiliary agent, the ability of medicinal liquid osmosis blade face wax coat and cuticula can be improved, it is made more to smoothly enter leaf inner tissue,
Oil based system is conducive to improve deposition capability, the resistance to rainwater of medicament and washes away ability and anti-rising ability simultaneously, these effects
Drug effect is promoted to play, plays apparent synergistic effect.Although being prepared as dispersible oil-suspending agent with above-mentioned advantage, whether may be used
The key of the product containing mesotrione oil dispersion is developed in success, is how mesotrione to be inhibited to divide in a dispersion medium
Solution problem, this point are also recognized in industry.Test of many times finds that mesotrione easily divides in oiliness decentralized medium system
Solution, and darkening for system can be caused.At present, dispersible oil-suspending agent production of many producers in the market containing mesotrione
Product, the resolution ratio in 1 year is generally more than 20%, and product can become reddish brown by white or yellowish when dispatching from the factory mostly
Color or even dark brown.Which results in surplus goods or too low, quality variation of returning the inventories content such as goods, and cause next year without
Method continues again and again to occur the problem of sale.In view of mesotrione oil dispersion it is influenced by factors decomposition and reduce
Activity finally influences drug effect, thus prevents active ingredient from decomposing, and it is agriculture to keep stabilization of the active ingredient in transportational process is stored
The difficult point of medicine technical field research.
For mesotrione resolution ratio problem, domestic certain pesticide producing enterprises are using expected current year formulation requirements amount, root
The problems such as being produced according to demand, reduce inventory as far as possible, gone bad to prevent preparation, can not being sold, so as to reduce loss as temporary
Solution.Also there are patent or article report for the stabilizer of mesotrione oil dispersion, it can be through its narration
Inhibit the decomposition of mesotrione to a certain extent, such as Chinese invention patent CN103583520A.In addition, it is commercially available have it is stabilizing agent specially used
Product, but its ingredient does not disclose, and effect needs clearly to be verified.And then need to be needed that mesotrione significantly can effectively be inhibited to divide
The dispersible oil-suspending agent of decomposition in dispersion media.
Invention content
It is an object of the invention to develop a kind of dispersible oil-suspending agent containing mesotrione.
To achieve the above object, the technical solution adopted by the present invention is：
A kind of dispersible oil-suspending agent containing mesotrione contains mesotrione in dispersible oil-suspending agent active component,
And add in stabilizer；Wherein, stabilizer addition accounts for the 0.1-5wt% of dispersible oil-suspending agent system.
Described preferred, stabilizer addition accounts for the 0.2-1wt% of dispersible oil-suspending agent system.
Dispersible oil-suspending agent active component of the present invention can also include other herbicides in addition to mesotrione, than
Such as nicosulfuron, atrazine.
The stabilizer is phytic acid (also known as phytic acid), one kind in soybean lecithin, trisnonyl phenyl phosphite
It is or several.
The preparation of dispersible oil-suspending agent containing mesotrione can according to prior art be recorded or according to described below
It prepares.Wherein dispersible oil-suspending agent is made of active component, surfactant, thickener, nonaqueous dispersion medium and stabilizer.
Wherein, surfactant can be fatty alcohol polyoxyethylene ether, polyethylene glycol monooleate, sorbitol polyoxyethylene
Ether, castor oil polyoxyethylene ether, sorbitan fatty acid ester, sorbitan fatty acid ester polyoxyethylene ether, phenethyl phenol
One or more of polyoxyethylene poly-oxygen propylene aether and formaldehyde condensation products；
Thickener can be one or more of xanthans, white carbon, diatomite, organobentonite, aluminium-magnesium silicate；
Nonaqueous dispersion medium can be one kind in vegetable oil, mineral oil, methyl oleate, butyl oleate, phthalic acid ester
It is or several.
What the present invention had has the beneficial effect that：
The dispersible oil-suspending agent of present invention addition stabilizer can reduce decomposition of the mesotrione in oils decentralized medium,
It can guarantee the relative rate of resolution of mesotrione below 5% in heat storage stability experiment；The face of formulation aesthetics can especially be prevented
Color increases deeply, and the dispersible oil-suspending agent formulation products containing mesotrione is made to store and keep mesotrione in transportational process
Stable state；Stabilizer of the present invention is good to the adaptability of former pharmaceutical formulation, either dividing to mesotrione single dose
Scattered oil-suspending agent still compounds the dispersible oil-suspending agent of mixture of other compositions, and being showed no influences the original physical chemistry of preparation
Energy.
It is mostly at present organic acid applied to the stabilizer containing mesotrione oil dispersion, from regulation system pH value
Start with and mitigate the decomposition of active ingredient mesotrione.The stabilizer that the present invention selects is applied in dispersible oil-suspending agent, is passed through
The performance of its antioxidation, decomposition of the inhibitory activity ingredient mesotrione in oiliness decentralized medium, so as to ensure preparation
Performance and good drug effect significantly effectively can inhibit mesotrione to decompose in a dispersion medium, by the resolution ratio of mesotrione
4% hereinafter, when addition is preferred, resolution ratio can be down to 3% hereinafter, this quantitative criteria is in industry leading water for control
It is flat.By skilled person will appreciate that when resolution ratio is larger, formulation aesthetics color can significantly increase depth, present invention addition stabilizer
Dispersible oil-suspending agent resolution ratio control 4% hereinafter, which ensure that preparation store and transportational process in appearance color,
The holding of stable state.
Specific embodiment
Specific examples below is for the present invention will be described in detail, but the present invention is not limited only to these examples.All formulations
Formula in percentage be weight percentage.Active component folding hundred is post-dised in formula, and mesotrione is by Shenyang Kechuang
Chemical Company produces；Other auxiliary agents and raw material are commercially available conventional variety.
Test method and step：Stabilizer is added according to a certain percentage in the dispersible oil-suspending agent containing mesotrione,
Be stirred to obtain sample, by sample be divided into heat storage before, heat storage (54 ± 2) DEG C two samples.
After sample preparation is got well, storage at normal temperature is carried out immediately and measures sample active constituent content before storage；Heat is store into sample
Product are put into baking oven, and temperature is (54 ± 2) DEG C；After placing 14 days, its content is detected.The content measured before being store using heat is as in terms of compareing
Relative rate of resolution is calculated, heat storage resolution ratio≤5% is qualification.
Heat stores resolution ratio calculation formula：
Content × 100% before resolution ratio %=(content after content-heat storage before storage)/storage
1 15% mesotrione of embodiment disperses oil-suspending agent
Mesotrione 15%, fatty alcohol polyoxyethylene ether 4%, polyethylene glycol monooleate 6%, organobentonite BP183
1.5%, methyl oleate is supplied, and said components are mixed, and progress high shear is pre-dispersed, is then added in sand milling kettle, is ground
3h obtains sample；
Stabilizer is added in the sample, after stirring 0.5h, obtains final preparation.Stabilizer addition refers to table 1.
The content of sample after sample, heat storage before storage is measured, and calculate its resolution ratio using high performance liquid chromatography,
Measurement result is shown in Table 1.
1 15% mesotrione oil dispersion stability test result of table
The above test results show that phytic acid, soybean lecithin are added in 15% mesotrione oil dispersion
Fat, trisnonyl phenyl phosphite can make stability of the active ingredient during heat is store increase as stabilizer.It is right
For phytic acid, addition is best for 0.2%；For soybean lecithin, addition is best for 0.3%；For
For trisnonyl phenyl phosphite, addition is best for 0.2%.
The 2 28% dispersible oil-suspending agent of mesotrione atrazine of embodiment
Mesotrione 4%, atrazine 24%, fatty alcohol polyoxyethylene ether 6%, sorbitol polyoxyethylene ether 4%, organic bentonite
Moistening soil BP183 1%, methyl oleate is supplied, and said components are mixed, and progress high shear is pre-dispersed, is then added in sand milling kettle,
3h is ground, obtains sample；
Stabilizer is added in the sample, after stirring 0.5h, obtains final preparation.Stabilizer addition refers to table 2.
The mesotrione content in sample after sample, heat storage before storage is measured, and count using high performance liquid chromatography
Its resolution ratio is calculated, measurement result is shown in Table 2.
The dispersible oil-suspending agent stability test result of 2 28% mesotrione atrazine of table
The above test results show that in the 28% dispersible oil-suspending agent of mesotrione atrazine add in phytic acid,
Soybean lecithin, trisnonyl phenyl phosphite can make stability of the mesotrione during heat is store as stabilizer
It improves.For phytic acid, addition is best for 0.2%；For soybean lecithin, addition is 0.3% most
It is good；For trisnonyl phenyl phosphite, addition is best for 0.2%.
The 3 26% dispersible oil-suspending agent of mesotrione nicosulfuron atrazine of embodiment
Mesotrione 4%, nicosulfuron 2%, atrazine 20%, castor oil polyoxyethylene ether 6%, sorbitol polyoxyethylene
Ether 4%, organobentonite BP183 0.8%, methyl oleate is supplied, and said components are mixed, and progress high shear is pre-dispersed, then
It adds in sand milling kettle, is ground 3h, obtains sample；
Stabilizer is added in the sample, after stirring 0.5h, obtains final preparation.Stabilizer addition refers to table 3.
The mesotrione content in sample after sample, heat storage before storage is measured, and count using high performance liquid chromatography
Its resolution ratio is calculated, measurement result is shown in Table 3.
The 3 26% dispersible oil-suspending agent stability test result of mesotrione nicosulfuron atrazine of table
The above test results show that add in flesh in the 26% dispersible oil-suspending agent of mesotrione nicosulfuron atrazine
Six phosphoric acid of alcohol, soybean lecithin, trisnonyl phenyl phosphite can make mesotrione during heat is store as stabilizer
Stability increases.For phytic acid, addition is best for 0.2%；For soybean lecithin, addition
It is best for 0.3%；For trisnonyl phenyl phosphite, addition is best for 0.2%.
Claims (2)
1. a kind of dispersible oil-suspending agent, it is characterised in that：Contain mesotrione in dispersible oil-suspending agent active component, and add
Enter stabilizer；Wherein, stabilizer addition accounts for the 0.1-5wt% of dispersible oil-suspending agent system；
The stabilizer is one or more of phytic acid, soybean lecithin, trisnonyl phenyl phosphite.
2. dispersible oil-suspending agent as described in claim 1, it is characterised in that：It is outstanding that the stabilizer addition accounts for dispersible oil
The 0.2-1wt% of floating agent system.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410828924.0A CN105766896B (en) | 2014-12-25 | 2014-12-25 | A kind of dispersible oil-suspending agent |
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| CN201410828924.0A CN105766896B (en) | 2014-12-25 | 2014-12-25 | A kind of dispersible oil-suspending agent |
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| CN105766896A CN105766896A (en) | 2016-07-20 |
| CN105766896B true CN105766896B (en) | 2018-07-03 |
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| CN115399317B (en) * | 2017-06-13 | 2024-08-27 | 禾大公司 | Agrochemical electrolyte composition |
| CN111084190A (en) * | 2019-12-04 | 2020-05-01 | 河北威远生物化工有限公司 | Insecticidal composition containing emamectin benzoate B2a and application thereof |
| CN112715544A (en) * | 2021-01-27 | 2021-04-30 | 山东科太药业有限公司 | Pesticide composition for preventing and treating plant powdery mildew |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007036939A2 (en) * | 2005-09-27 | 2007-04-05 | Sol-Gel Technologies Ltd. | Methods for crop protection |
| CN103027045A (en) * | 2012-12-14 | 2013-04-10 | 青岛东生药业有限公司 | Oil miscible flowable concentrate containing mesotrione and clopyralid |
| CN103503862A (en) * | 2013-09-10 | 2014-01-15 | 江苏长青农化股份有限公司 | Mesotrione oil suspension agent composition |
| CN103583520A (en) * | 2013-11-04 | 2014-02-19 | 美丰农化有限公司 | Mesotrione oil dispersion and preparation method thereof |
-
2014
- 2014-12-25 CN CN201410828924.0A patent/CN105766896B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007036939A2 (en) * | 2005-09-27 | 2007-04-05 | Sol-Gel Technologies Ltd. | Methods for crop protection |
| CN103027045A (en) * | 2012-12-14 | 2013-04-10 | 青岛东生药业有限公司 | Oil miscible flowable concentrate containing mesotrione and clopyralid |
| CN103503862A (en) * | 2013-09-10 | 2014-01-15 | 江苏长青农化股份有限公司 | Mesotrione oil suspension agent composition |
| CN103583520A (en) * | 2013-11-04 | 2014-02-19 | 美丰农化有限公司 | Mesotrione oil dispersion and preparation method thereof |
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Effective date of registration: 20210730 Address after: 110021 Shenyang Liaodong Road, Tiexi District, Shenyang, Liaoning 8-1 Patentee after: SHENYANG SINOCHEM AGROCHEMICALS R&D Co.,Ltd. Patentee after: SHENYANG SCIENCREAT CHEMICALS Co.,Ltd. Address before: 110021 Shenyang Liaodong Road, Tiexi District, Shenyang, Liaoning 8-1 Patentee before: SHENYANG SINOCHEM AGROCHEMICALS R&D Co.,Ltd. |