CN105766896A - Dispersible oil suspending agent - Google Patents
Dispersible oil suspending agent Download PDFInfo
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- CN105766896A CN105766896A CN201410828924.0A CN201410828924A CN105766896A CN 105766896 A CN105766896 A CN 105766896A CN 201410828924 A CN201410828924 A CN 201410828924A CN 105766896 A CN105766896 A CN 105766896A
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- suspending agent
- mesotrione
- dispersible oil
- oil
- oil suspending
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Abstract
The invention belongs to the technical field of pesticide, and particularly relates to a dispersible oil suspending agent containing mesotrione.Mesotrione is included in an active component of the dispersible oil suspending agent, and a stabilizing agent is added.The adding quantity of the stabilizing agent accounts for 0.1-5% by weight of a dispersible oil suspending agent system.According to the dispersible oil suspending agent to which the stabilizing agent is added, the amount of mesotrione decomposed in an oil dispersion medium can be reduced, and it can be guaranteed that the relative decomposition rate of mesotrione in a thermal stability experiment is 5% or below.Especially, increase of the color of the appearance of a preparation can be stopped, and the stable state of mesotrione is kept in the storage and transportation process of the dispersible oil suspending agent product containing mesotrione.The stabilizing agent involved in the dispersible oil suspending agent is good in adaptability to an original preparation formula, and the original physical and chemical performance of the preparation is not influenced for no matter the dispersible oil suspending agent of a single mesotrione agent or a mixed dispersible oil suspending agent compounded with other ingredients.
Description
Technical field
The invention belongs to technical field of pesticide, particularly relate to a kind of oil that dispersibles containing mesotrione and hang
Floating agent.
Background technology
Mesotrione has another name called " mesotrione ", is that one can suppress medical midbodies of para (ortho)-hydroxybenzoic acetone acid esters dual oxide enzyme
(HPPD) wide spectrum selective herbicide before bud and after Seedling, can effectively prevent and treat main broadleaved herb and some standing grain
Undergraduate course weeds.Mesotrione easily conducts at plant xylem and phloem, has action of contace poison and wholesomeness.
The development dispersibling oil-suspending agent starts from the later stage seventies, the most gradually grows up to the eighties.By
Still have compared with cream preparation in many cases in water baseization, spheroidizing application effect of products particularly drug effect
A certain distance, dispersibling oil-suspending agent in some cases is an ideal selection mode.
It is prepared as dispersibling oil-suspending agent by mesotrione, by the use of oils disperse medium and be applicable to
The interpolation of oil based system auxiliary agent, can improve medicinal liquid osmosis blade face wax coat and cuticular ability so that it is more suitable
Entering leaf inner tissue, oil based system is conducive to improving the deposition capability of medicament simultaneously, resistance to rainwater washes away energy sharply
Power and anti-rising ability, these effects all can promote that drug effect plays, and plays obvious potentiation.Although system
Whether standby have an above-mentioned advantage for dispersibling oil-suspending agent, but can successfully develop and dispersible oil containing mesotrione and hang
The key of floating agent product, is the resolution problem how suppressing mesotrione in disperse medium, and this point is also
Recognized by industry.Test of many times finds, mesotrione is extremely easy in decomposition in oiliness disperse medium system, and
Darkening of system can be caused.At present, the oil that dispersibles containing mesotrione of the many producers on market suspends
Agent product, the resolution ratio in a year is generally more than 20%, and product mostly can be by white when dispatching from the factory or micro-
Yellow becomes rufous, even pitchy.Which results in surplus goods or to return the inventory content such as goods too low,
Quality variation, and make next year cannot continue sell problem again and again occur.In view of mesotrione dispersibles
Oil-suspending agent decomposition influenced by factors and reduce activity, finally affect drug effect, thus prevent from effectively becoming
Decomposing, holding effective ingredient stablizing in storage transportation is the difficult point of technical field of pesticide research.
For mesotrione resolution ratio problem, some pesticide producing enterprise domestic uses expects formulation requirements then
Amount, measures production according to demand, reduces stock as far as possible, in case preparation goes bad, it is impossible to problems such as sale, from
And reduce loss as temporary transient solution.Stabilizer for mesotrione oil dispersion also has specially
Profit or article report, can suppress the decomposition of mesotrione to a certain extent, such as Chinese invention through its narration
Patent CN103583520A.A stabilizing agent specially used product is had additionally, commercially available, but its composition being not disclosed, effect
Need clearly to be verified.And then need the decomposition needing can the most effectively to suppress mesotrione in disperse medium
Dispersible oil-suspending agent.
Summary of the invention
It is an object of the invention to develop and a kind of dispersible oil-suspending agent containing mesotrione.
For achieving the above object, the technical solution used in the present invention is:
A kind of dispersible oil-suspending agent containing mesotrione, dispersible in oil-suspending agent active component containing nitre sulphur
Oxadiazon, and add stabilizer；Wherein, stabilizer addition accounts for the 0.1-5wt% dispersibling oil-suspending agent system.
Described preferably, stabilizer addition accounts for the 0.2-1wt% dispersibling oil-suspending agent system.
The oil-suspending agent active component that dispersibles of the present invention is in addition to mesotrione, it is also possible to comprise other weedings
Agent, such as nicosulfuron, atrazine etc..
Described stabilizer is in phytic acid (having another name called phytic acid), soybean lecithin, trisnonyl phenyl phosphite
One or more.
The preparation dispersibling oil-suspending agent containing mesotrione can according to the record of prior art, or according under
State description preparation.Wherein dispersible oil-suspending agent by active component, surfactant, thickening agent, non-moisture
Dispersion media and stabilizer composition.
Wherein, surfactant can be fatty alcohol-polyoxyethylene ether, polyethylene glycol monooleate, sorbitol
Polyoxyethylene ether, castor oil polyoxyethylene ether, sorbitan fatty acid ester, sorbitan fatty acid ester
One or more in polyoxyethylene ether, phenethyl phenol polyethenoxy polyethenoxy ether and formaldehyde condensation products；
Thickening agent can be the one in xanthan gum, white carbon, kieselguhr, organobentonite, aluminium-magnesium silicate
Or it is several；
Nonaqueous dispersion medium can be vegetable oil, mineral oil, methyl oleate, butyl oleate, phthalic acid ester
In one or more.
What the present invention possessed has the beneficial effect that
The present invention adds dispersibling oil-suspending agent and reducing mesotrione in oils disperse medium of stabilizer
Decompose, in heat storage stability is tested, can guarantee that the relative rate of resolution of mesotrione is below 5%；Can hinder especially
Only the color of formulation aesthetics increases deep, make containing mesotrione dispersible oil-suspending agent formulation products in storage and
Transportation keeps the steady statue of mesotrione；Former pharmaceutical formulation is fitted by the stabilizer that the present invention relates to
Answering property is good, either mesotrione single dose is dispersibled oil-suspending agent still compound the mixture of other compositions can
Dispersed oil suspending agent, is showed no and affects the original physical and chemical performance of preparation.
It is applied to the stabilizer containing mesotrione oil dispersion at present and mostly is organic acid, from regulation body
It is that pH value is started with and alleviated the decomposition of effective ingredient mesotrione.The stabilizer that the present invention selects is applied to dispersible
In oil-suspending agent, by the performance of its antioxidation, inhibitory activity composition mesotrione is situated between in oiliness dispersion
Decomposition in matter, thus ensure the performance of preparation and good drug effect, can the most effectively suppress mesotrione to exist
Decomposition in disperse medium, controls below 4% by the resolution ratio of mesotrione, when addition is preferred, decomposes
Rate can be down to less than 3%, and this quantitative criteria is in industry top standard.By skilled person will appreciate that
When resolution ratio is bigger, formulation aesthetics color can substantially increase deeply, and the present invention adds the oil that dispersibles of stabilizer and hangs
The resolution ratio of floating agent controls below 4%, which ensure that preparation appearance color, steady in storage and transportation
Determine the holding of state.
Detailed description of the invention
Specific examples below is used for describing in detail the present invention, but the present invention is not limited only to these examples.Institute
Percentage ratio in the formula of preparation is had all to be weight percentage.In formula, active component is rolled over hundred post-dised, nitre
Sulphur oxadiazon is produced by Shenyang Sciencreat Chemicals Co., Ltd.；Other auxiliary agents and raw material are commercially available conventional variety.
Test method and step: stabilizer is added according to a certain percentage the oil that dispersibles containing mesotrione and suspends
In agent, stirring be mixed to get sample, sample is divided into heat storage before, heat storage (54 ± 2) DEG C two samples.
After good for sample preparation, carry out storage at normal temperature immediately and measure sample active constituent content before storage；Will
Baking oven put into by heat storage sample, and temperature is (54 ± 2) DEG C；After placing 14 days, detect its content.Store with heat
The content of front mensuration calculates relative rate of resolution as comparison, and heat storage resolution ratio≤5% is qualified.
Heat storage resolution ratio computing formula is:
Content × 100% before resolution ratio %=(content after content-heat storage before storage)/storage
Embodiment 1 15% mesotrione dispersed oil suspending agent
Mesotrione 15%, fatty alcohol-polyoxyethylene ether 4%, polyethylene glycol monooleate 6%, organobentonite
BP183 1.5%, methyl oleate is supplied, and said components is mixed, carries out high shear pre-dispersed, be subsequently adding
In sand milling still, it is ground 3h, obtains sample；
Add stabilizer in the sample, after stirring 0.5h, obtain final preparation.Stabilizer addition refers to
Table 1.
Use high performance liquid chromatography that the content of sample after sample, heat storage before storage is measured, and calculate it
Resolution ratio, measurement result is shown in Table 1.
Table 1 15% mesotrione oil dispersion stability test result
Above result of the test shows, adds phytic acid, Semen sojae atricolor in 15% mesotrione oil dispersion
Lecithin, trisnonyl phenyl phosphite can make effective ingredient stablizing during heat is store as stabilizer
Property increases.For phytic acid, addition is 0.2% optimal；For soybean lecithin,
Addition is 0.3% optimal；For trisnonyl phenyl phosphite, addition is 0.2% optimal.
Embodiment 2 28% mesotrione atrazine dispersibles oil-suspending agent
Mesotrione 4%, atrazine 24%, fatty alcohol-polyoxyethylene ether 6%, sorbitol polyoxyethylene ether 4%,
Organobentonite BP183 1%, methyl oleate is supplied, and said components is mixed, carries out high shear pre-dispersed,
It is subsequently adding in sand milling still, is ground 3h, obtain sample；
Add stabilizer in the sample, after stirring 0.5h, obtain final preparation.Stabilizer addition refers to
Table 2.
Use high performance liquid chromatography that the mesotrione content in sample after sample, heat storage before storage is measured,
And calculating its resolution ratio, measurement result is shown in Table 2.
Table 2 28% mesotrione atrazine dispersibles oil-suspending agent stability test result
Above result of the test shows, 28% mesotrione atrazine dispersibles addition inositol six phosphorus in oil-suspending agent
Acid, soybean lecithin, trisnonyl phenyl phosphite can make mesotrione store process in heat as stabilizer
In stability increase.For phytic acid, addition is 0.2% optimal；For Semen sojae atricolor ovum
For phospholipid, addition is 0.3% optimal；For trisnonyl phenyl phosphite, addition is 0.2%
Good.
Embodiment 3 26% mesotrione nicosulfuron atrazine dispersibles oil-suspending agent
Mesotrione 4%, nicosulfuron 2%, atrazine 20%, castor oil polyoxyethylene ether 6%, sorbitol gathers
Oxygen vinyl Ether 4%, organobentonite BP183 0.8%, methyl oleate is supplied, and said components is mixed, carries out
High shear is pre-dispersed, is subsequently adding in sand milling still, is ground 3h, obtains sample；
Add stabilizer in the sample, after stirring 0.5h, obtain final preparation.Stabilizer addition refers to
Table 3.
Use high performance liquid chromatography that the mesotrione content in sample after sample, heat storage before storage is measured,
And calculating its resolution ratio, measurement result is shown in Table 3.
Table 3 26% mesotrione nicosulfuron atrazine dispersibles oil-suspending agent stability test result
Above result of the test shows, 26% mesotrione nicosulfuron atrazine dispersibles in oil-suspending agent and adds
Phytic acid, soybean lecithin, trisnonyl phenyl phosphite can make mesotrione exist as stabilizer
Stability during heat storage increases.For phytic acid, addition is 0.2% optimal；Right
For soybean lecithin, addition is 0.3% optimal；For trisnonyl phenyl phosphite, addition
It is 0.2% optimal.
Claims (3)
1. one kind dispersibles oil-suspending agent, it is characterised in that: dispersible in oil-suspending agent active component containing nitre
Sulphur oxadiazon, and add stabilizer；Wherein, stabilizer addition accounts for the 0.1-5wt% dispersibling oil-suspending agent system.
2. as described in claim 1, dispersible oil-suspending agent, it is characterised in that: described stabilizer addition
Account for the 0.2-1wt% dispersibling oil-suspending agent system.
3. as described in claim 1 or 2, dispersible oil-suspending agent, it is characterised in that: described stabilizer is
One or more in phytic acid, soybean lecithin, trisnonyl phenyl phosphite.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410828924.0A CN105766896B (en) | 2014-12-25 | 2014-12-25 | A kind of dispersible oil-suspending agent |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410828924.0A CN105766896B (en) | 2014-12-25 | 2014-12-25 | A kind of dispersible oil-suspending agent |
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| CN105766896A true CN105766896A (en) | 2016-07-20 |
| CN105766896B CN105766896B (en) | 2018-07-03 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110740642A (en) * | 2017-06-13 | 2020-01-31 | 禾大公司 | Agrochemical electrolyte compositions |
| CN111084190A (en) * | 2019-12-04 | 2020-05-01 | 河北威远生物化工有限公司 | Insecticidal composition containing emamectin benzoate B2a and application thereof |
| CN112715544A (en) * | 2021-01-27 | 2021-04-30 | 山东科太药业有限公司 | Pesticide composition for preventing and treating plant powdery mildew |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007036939A2 (en) * | 2005-09-27 | 2007-04-05 | Sol-Gel Technologies Ltd. | Methods for crop protection |
| CN103027045A (en) * | 2012-12-14 | 2013-04-10 | 青岛东生药业有限公司 | Oil miscible flowable concentrate containing mesotrione and clopyralid |
| CN103503862A (en) * | 2013-09-10 | 2014-01-15 | 江苏长青农化股份有限公司 | Mesotrione oil suspension agent composition |
| CN103583520A (en) * | 2013-11-04 | 2014-02-19 | 美丰农化有限公司 | Mesotrione oil dispersion and preparation method thereof |
-
2014
- 2014-12-25 CN CN201410828924.0A patent/CN105766896B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007036939A2 (en) * | 2005-09-27 | 2007-04-05 | Sol-Gel Technologies Ltd. | Methods for crop protection |
| CN103027045A (en) * | 2012-12-14 | 2013-04-10 | 青岛东生药业有限公司 | Oil miscible flowable concentrate containing mesotrione and clopyralid |
| CN103503862A (en) * | 2013-09-10 | 2014-01-15 | 江苏长青农化股份有限公司 | Mesotrione oil suspension agent composition |
| CN103583520A (en) * | 2013-11-04 | 2014-02-19 | 美丰农化有限公司 | Mesotrione oil dispersion and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110740642A (en) * | 2017-06-13 | 2020-01-31 | 禾大公司 | Agrochemical electrolyte compositions |
| CN111084190A (en) * | 2019-12-04 | 2020-05-01 | 河北威远生物化工有限公司 | Insecticidal composition containing emamectin benzoate B2a and application thereof |
| CN112715544A (en) * | 2021-01-27 | 2021-04-30 | 山东科太药业有限公司 | Pesticide composition for preventing and treating plant powdery mildew |
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|---|---|
| CN105766896B (en) | 2018-07-03 |
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Effective date of registration: 20210730 Address after: 110021 Shenyang Liaodong Road, Tiexi District, Shenyang, Liaoning 8-1 Patentee after: SHENYANG SINOCHEM AGROCHEMICALS R&D Co.,Ltd. Patentee after: SHENYANG SCIENCREAT CHEMICALS Co.,Ltd. Address before: 110021 Shenyang Liaodong Road, Tiexi District, Shenyang, Liaoning 8-1 Patentee before: SHENYANG SINOCHEM AGROCHEMICALS R&D Co.,Ltd. |
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