CN105754013A - Preparation process of magnesium potassium alginate - Google Patents
Preparation process of magnesium potassium alginate Download PDFInfo
- Publication number
- CN105754013A CN105754013A CN201610160247.9A CN201610160247A CN105754013A CN 105754013 A CN105754013 A CN 105754013A CN 201610160247 A CN201610160247 A CN 201610160247A CN 105754013 A CN105754013 A CN 105754013A
- Authority
- CN
- China
- Prior art keywords
- magnesium
- potassium
- alginic acid
- carbonate
- centrifugal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
Abstract
The invention discloses a preparation process of magnesium potassium alginate. The preparation process is characterized by comprising steps as follows: (1) an excessive amount of alginic acid and compound potassium salt are subjected to a neutralization reaction for 15-20 min; (2) an excessive amount of magnesium carbonate is added for a neutralization reaction; (3) centrifugation is performed after complete reaction, and a centrifuged product is roughly crushed and dissolved in water; (4) after complete dissolution, centrifugation is performed, water insoluble substances are removed, and ethanol precipitation is performed on a water solution; (5) finally, the magnesium potassium alginate is prepared through centrifugation, freeze drying and crushing. The magnesium potassium alginate contains alginic acid, magnesium ions, potassium ions, carbonate and bicarbonate radical in the molecule structure, has biological activity of magnesium, potassium and alginic acid, has multiple functions of protection of stomach and intestinal mucosa, neutralization of gastric acid, reduction of blood pressure, a magnesium replenisher and the like, is a high-quality crude drug and has good new drug and health-care food development value.
Description
Technical field
The present invention relates to the preparation technology of a kind of crude drug and application, specifically the preparation technology of a kind of alginic acid magnesium potassium.
Background technology
Hypertension (another name: hypertension is English: feritin) being the topmost risk factor of cardiovascular and cerebrovascular disease, apoplexy, heart failure and chronic kidney disease are its major complications.Along with the life stress day by day increased and the quality of the life increasingly become more meticulous, hypertension is no longer the exclusive disease of old people, it has become the multiple and occurred frequently disease of modern's (especially young and middle-aged), and very easily causes the complication such as coronary heart disease, cardiovascular and cerebrovascular disease.Reduce the blood pressure level of hyperpietic, can obviously reduce apoplexy and the events of heart attack, significantly improve the life quality of patient, effectively reduce Disease Spectrum.
Sodium-potassium balance in circulating according to human body fluid is theoretical, and kalium replenishment is the one mode fast and effectively reduced blood pressure.Therefore, low molecule potassium alginate is widely used in medicine and the health product of blood pressure lowering, and it can regulate and prophylaxis of hypertension, retarding cardiovascular is old and feeble, improve microcirculation.In many patents and document (health food such as a CN200410027637-blood pressure lowering), all have employed the potassium alginate functional component as composite health food and medicine.Meanwhile, magnesium is also one of indispensable mineral element of human body, and magnesium almost participates in all of metabolic processes of human body, and in cell, its content is only second to potassium, and health will necessarily be worked the mischief by the shortage of magnesium elements." passage " that magnesium affects potassium, sodium, calcium ion intraor extracellular move, and have the effect maintaining biomembrane current potential.It is reported, hyperpietic is serious magnesium deficiency often, and therefore, it is extremely beneficial that magnesium potassium element mends the alleviation for hypertension and cardiovascular and cerebrovascular disease altogether.
Meanwhile, depressor is generally long-term prescription and very easily causes the damage of gastric mucosa.To the crowd suffering from gastropathy and hypertension simultaneously, damage and the gastrointestinal portion pain born of its gastrointestinal mucosa are all ineffable by long-term absorption depressor.
Gastropathy has become as, in current fast-developing society, the class disease that people are very general, and the serious threat mankind's is healthy.Current stomach medicine on the market is of a great variety; it is divided into four big classes: neutralize gastric acid class stomach medicine, gastric acid inhibitory class stomach medicine, protection mucosa class stomach medicine and promote gastric motility class stomach medicine; wherein rapid-action is neutralize gastric acid class stomach medicine; but this type of drug treating time is relatively short, causes because the release of effective group is too fast that insecondary gastric acid is on the high side, belch, see the side effect such as mass formed by blood stasis and alkalized urine;Protection mucosa class stomach medicine is stomach medicine instantly the most prevailing, and its effect is not only in that gastrointestinal tract mucous barrier is protected in formation, also has cytoprotection, and can promote mucous secretion, strengthens mucus barrier effect.
There is certain untoward reaction in the stomach medicine of application single variety, and does not reach promising result clinically, and therefore several compound preparations of many employings make up for each other's deficiencies and learn from each other clinically, to reduce untoward reaction.If gavirin tablet (having another name called alginic acid magnalium) is the mixture being made up of alginic acid, aluminium hydroxide, magnesium trisilicate, both possessed alginic acid film property, gelation, it may have neutralize the effect of gastric acid.
In summary: develop this multifunctional drug and health food additive be instantly with following study hotspot.
Summary of the invention
The present invention, based on actual demand, has invented a kind of alginic acid magnesium potassium, product of the present invention be one containing alginic acid, magnesium, potassium ion, carbonate, bicarbonate radical monomer-polymer.
To achieve these goals, the technical solution used in the present invention is:
A kind of preparation technology of alginic acid magnesium potassium.It is characterized in that comprising the steps of
(1) in excessive alginic acid and compound potassium salt and react 15~20min;
(2) add excessive magnesium carbonate again, be neutralized reaction;
(3) centrifugal after complete reaction, centrifugal product coarse pulverization water dissolves;
(4) it is completely dissolved rear centrifugal segregation water-insoluble, aqueous solution precipitate with ethanol;
(5) finally centrifugal, lyophilization, pulverizing prepare alginic acid magnesium potassium.
Technical scheme is improved further: in described step (1), compound potassium salt is one or both in potassium hydroxide, potassium carbonate.
Technical scheme is improved further: the medium neutralizing reaction in described step (1) is ethanol, alcoholic strength >=70%vol (standard temperature 20 DEG C).
Technical scheme is improved further: alginic acid in described step (1) (2), compound potassium salt, magnesium carbonate mass ratio be 22:2~3:4~6.
Alginic acid magnesium potassium of the present invention; molecular structure comprises alginic acid; magnesium, potassium ion, carbonate, bicarbonate radical; have neutralization acid and alginic acid biological activity concurrently; there is stomach, intestinal mucosa protection, neutralize the multi-efficiencies such as gastric acid, blood pressure lowering, magnesium supplement agent; it is the crude drug of a kind of high-quality, there is the Development volue of good medicine, feedstuff and food supplement.
Compared with prior art, advantages of the present invention and having the benefit effect that
Alginic acid magnesium potassium molecular structure of the present invention comprises alginic acid; magnesium, potassium ion, carbonate, bicarbonate radical; both there is the film property of alginic acid, gelation; high intensity protecting film one layer not easily destroyed can be formed on gastric mucosa; strengthen the barrier protection effect of gastric mucosa; antacid composition therein (carbonate, bicarbonate radical) can be avoided to contact rapidly with gastric acid; being that a kind of character is gentle, efficient neutralizes gastric acid class stomach medicine; its antiacid action temperature and acting duration are long; response rate is high, anacidity knock-on, without alkalemia.Meanwhile, there is again magnesium, potassium ion, it is possible to long-term taking, be effectively reduced the blood pressure of patient, therefore can have the special patient groups of hypertension for suffering from gastrointestinal disease simultaneously.
Accompanying drawing explanation
Fig. 1 is the preparation technology flow chart of a kind of alginic acid magnesium potassium provided by the invention.
Specific embodiment
Embodiment 1
Table 1
Component | Quality (kg) |
Alginic acid | 22 |
Potassium hydroxide | 2 |
Magnesium carbonate | 6 |
Weighing each component according to table 1, concrete production technology is as follows:
(1) first alginic acid and potassium hydroxide are placed in the neutralizing tank containing 70%vol alcoholic solution, are neutralized reaction 16min;
(2) in neutralizing tank, add magnesium carbonate again, continue reaction, until alginic acid complete reaction;
(3) complete reaction is centrifuged, and after centrifugal 40min, takes out centrifugal product coarse pulverization coarse powder, is placed in the neutralizing tank of water filling by the floccule after pulverizing, and stirring is to being completely dissolved;
(4) being completely dissolved rear centrifugal segregation water-insoluble, add 95% ethanol of aqueous solution 2-3 times, stirring precipitates out product;
(5) centrifugal obtain alcohol hypostasis, lyophilization, pulverize, the alginic acid magnesium potassium of the desired particle size that sieves, prepares.
Embodiment 2
Table 2
Component | Quality (kg) |
Alginic acid | 22 |
Potassium carbonate | 3 |
Magnesium carbonate | 4 |
Weighing each component according to table 2, concrete production technology is as follows:
(1) first alginic acid and potassium carbonate are placed in the neutralizing tank containing 72%vol alcoholic solution, are neutralized reaction 20min;
(2) in neutralizing tank, add magnesium carbonate again, continue reaction, until alginic acid complete reaction;
(3) complete reaction is centrifuged, and after centrifugal 40min, takes out centrifugal product coarse pulverization coarse powder, is placed in the neutralizing tank of water filling by the floccule after pulverizing, and stirring is to being completely dissolved;
(4) being completely dissolved rear centrifugal segregation water-insoluble, add 95% ethanol of aqueous solution 2-3 times, stirring precipitates out product;
(5) centrifugal obtain alcohol hypostasis, lyophilization, pulverize, the alginic acid magnesium potassium of the desired particle size that sieves, prepares.
Embodiment 3
Table 3
Component | Quality (kg) |
Alginic acid | 22 |
Potassium hydroxide | 1 |
Potassium carbonate | 1 |
Magnesium carbonate | 5 |
Weighing each component according to table 3, concrete production technology is as follows:
(1) first alginic acid and potassium hydroxide, potassium carbonate are placed in the neutralizing tank containing 72%vol alcoholic solution, are neutralized reaction 18min;
(2) in neutralizing tank, add magnesium carbonate again, continue reaction, until alginic acid complete reaction;
(3) complete reaction is centrifuged, and after centrifugal 40min, takes out centrifugal product coarse pulverization coarse powder, is placed in the neutralizing tank of water filling by the floccule after pulverizing, and stirring is to being completely dissolved;
(4) being completely dissolved rear centrifugal segregation water-insoluble, add 95% ethanol of aqueous solution 2-3 times, stirring precipitates out product;
(5) centrifugal obtain alcohol hypostasis, lyophilization, pulverize, the alginic acid magnesium potassium of the desired particle size that sieves, prepares.
Claims (5)
1. the preparation technology of an alginic acid magnesium potassium.It is characterized in that comprising the steps of
(1) in excessive alginic acid and compound potassium salt and react 15~20min;
(2) add excessive hydrogen magnesium oxide again, be neutralized reaction;
(3) centrifugal after complete reaction, centrifugal product coarse pulverization water dissolves;
(4) it is completely dissolved rear centrifugal segregation water-insoluble, aqueous solution precipitate with ethanol;
(5) finally centrifugal, lyophilization, pulverizing prepare alginic acid magnesium potassium.
2. the preparation technology of a kind of alginic acid magnesium potassium according to claim 1, in step (1) described in its feature, compound potassium salt is one or both in potassium hydroxide, potassium carbonate.
3. the preparation technology of a kind of alginic acid magnesium potassium according to claim 1, the medium neutralizing reaction in step (1) described in its feature is ethanol, alcoholic strength >=70%vol (standard temperature 20 DEG C).
4. the preparation technology of a kind of alginic acid magnesium potassium according to claim 1, alginic acid in its characterization step (1) (2), compound potassium salt, magnesium carbonate mass ratio be 44:4.6~5.8:7~11.
5. alginic acid magnesium potassium described in any of the above-described claim; molecular structure comprises alginic acid; magnesium, potassium ion, carbonate, bicarbonate radical; have the biological activity of magnesium, potassium element and alginic acid concurrently; there is stomach, intestinal mucosa protection, neutralize the multi-efficiencies such as gastric acid, blood pressure lowering, magnesium supplement agent; it is the crude drug of a kind of high-quality, there is the Development volue of good medicine, food supplement.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610160247.9A CN105754013A (en) | 2016-03-21 | 2016-03-21 | Preparation process of magnesium potassium alginate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610160247.9A CN105754013A (en) | 2016-03-21 | 2016-03-21 | Preparation process of magnesium potassium alginate |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105754013A true CN105754013A (en) | 2016-07-13 |
Family
ID=56346086
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610160247.9A Pending CN105754013A (en) | 2016-03-21 | 2016-03-21 | Preparation process of magnesium potassium alginate |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105754013A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112646053A (en) * | 2020-12-21 | 2021-04-13 | 青岛海之林生物科技开发有限公司 | Preparation method and application of magnesium lithium alginate |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101889027B (en) * | 2007-12-29 | 2013-05-01 | 于传兴 | Alginic acid with low molecular weight, its salts, uses, preparative methods, pharmaceutical compositions and foods |
CN104688765A (en) * | 2013-12-04 | 2015-06-10 | 博晖(大连)实业有限公司 | Composition stomach medicine made from alginates |
CN104844726A (en) * | 2014-02-13 | 2015-08-19 | 青岛海之林生物科技开发有限公司 | Production technology of magnesium alginate |
-
2016
- 2016-03-21 CN CN201610160247.9A patent/CN105754013A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101889027B (en) * | 2007-12-29 | 2013-05-01 | 于传兴 | Alginic acid with low molecular weight, its salts, uses, preparative methods, pharmaceutical compositions and foods |
CN104688765A (en) * | 2013-12-04 | 2015-06-10 | 博晖(大连)实业有限公司 | Composition stomach medicine made from alginates |
CN104844726A (en) * | 2014-02-13 | 2015-08-19 | 青岛海之林生物科技开发有限公司 | Production technology of magnesium alginate |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112646053A (en) * | 2020-12-21 | 2021-04-13 | 青岛海之林生物科技开发有限公司 | Preparation method and application of magnesium lithium alginate |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103239482A (en) | Intragastric floating tablet for periplaneta americana as well as preparation method and application of intragastric floating tablet | |
CN106361993B (en) | Pharmaceutical composition for preventing and treating gastric mucosal injury and preparation method thereof | |
WO2016000508A1 (en) | Chinese herbal medicine for treating gout and preparation method thereof | |
CN108324921B (en) | A pharmaceutical composition with cyst removing and gastric mucosa protecting effects, and its preparation method | |
CN105754013A (en) | Preparation process of magnesium potassium alginate | |
CN108210477A (en) | Delay flexible glue cyst fluid, soft capsule and the forefront capsule and its preparation method of rubber aging | |
CN101422491B (en) | Preparation method of inonotus obilquus as alpha-glucosidase inhibitors | |
CN105754012A (en) | Preparation process of aluminum magnesium alginate | |
CN101693048A (en) | Medicament for treating ulcer and chronic gastritis | |
CN109820971A (en) | A kind of drug with antigout effect | |
CN101461906A (en) | Health product with function for removing liver-fire and improving eyesight as well as preparation method thereof | |
CN107602721A (en) | The method that acidic buffer solution extracts tremella polysaccharides | |
CN106924581A (en) | It is a kind of to treat medicinal liquor of stomachache and preparation method thereof | |
CN102335276B (en) | Preparation method and application of tree peony extract and composition of tree peony extract | |
CN102988422A (en) | American cockroach nano extract and preparation method thereof | |
CN101422487A (en) | Bear gall soft capsules and preparation method thereof | |
CN106165898A (en) | There is health composition of increase bone density, easing joint movement and preparation method thereof | |
CN105056059A (en) | Traditional Chinese medicine for treating gastropathy | |
CN110496148A (en) | A kind of eucommia ulmoides extracts composition that treating the hypertension of pregnancy and its application | |
CN103479824A (en) | Traditional Chinese medicine compound for treating chronic periodontitis and gastritis and preparation method thereof | |
CN103751255A (en) | Pachymaran composition for decreasing blood sugar and preparation method thereof | |
CN101757460A (en) | Traditional Chinese medicine preparation for treating gout | |
CN103285040A (en) | Method for preparing nano periplaneta americana | |
CN107811907A (en) | A kind of body lotion for promoting subcutaneous fat to decompose | |
KR102192251B1 (en) | Method for manufacturing a bamboo salt with bile of ox |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160713 |
|
WD01 | Invention patent application deemed withdrawn after publication |