CN101693048A - Medicament for treating ulcer and chronic gastritis - Google Patents
Medicament for treating ulcer and chronic gastritis Download PDFInfo
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- CN101693048A CN101693048A CN200910075703A CN200910075703A CN101693048A CN 101693048 A CN101693048 A CN 101693048A CN 200910075703 A CN200910075703 A CN 200910075703A CN 200910075703 A CN200910075703 A CN 200910075703A CN 101693048 A CN101693048 A CN 101693048A
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Abstract
The invention relates to a medicament for treating ulcer and chronic gastritis. A solid oral preparation, such as capsule, is prepared by the steps of uniformly mixing 200-300 parts of prepared concha arcae, 150-200 parts of prepared frankincense and 150-200 parts of prepared myrrh and crushing into granular sensation free fine powder according to the conventional procedures. The medicament is mainly used for treating the traditional stomachache, i.e. peptic ulcer of duodenum and stomach, chronic gastritis and the like in modern clinic; and clinical test results show that the effective rate reaches 96.3 percent.
Description
Technical field
The present invention relates to a kind of medicine that is used for the treatment of gastroenteropathy, particularly relating to a kind of is the medicine of treatment stomach, duodenal ulcer and the chronic gastritis of crude drug preparation with Chinese medicine.
Background technology
According to data, the total prevalence rate of gastrointestinal disease is up to more than 50%, and wherein Peptic Ulcers accounts for more than 10% again.As everyone knows, peptic ulcer is one of disease of comparison stubbornness, and relapse rate is very high, and year relapse rate is up to more than 70%, and as seen treatment is thorny.
From traditional traditional Chinese medical science viewpoint, peptic ulcer belongs to traditional Chinese medical science gastric abscess category, due to stomach-QI being unable to descend normally, " stagnation of QI and blood may bring about pain ".Sick position is at stomach, but dirty closely related with liver spleen two, irritability is easily violated stomach gram spleen, and taste can involve mutually, and how real liver is clinically, and how empty spleen is, the many qi depressions to blood stasis of stomach.
Explain that from the modern medicine study angle pathogeny of peptic ulcer disease mainly is the unbalance of the damage of gastrointestinal mucosa and protection factor, and helicobacter pylori " disturbing ".And causing peptic ulcer to have following two kinds of factors at least: various nonsteroid anti-inflammatory drugses suppress the generation of prostaglandin, the damage gastric mucosa; Gastroxia corrosion gastrointestinal mucosa.Medicine for ulcer in the market also roughly is divided into acid inhibitor, mucosa protective agent and antibacterial three classes.
At present, treat gastrointestinal disease such as peptic gastric ulcer clinically and adopt chemotherapy more, the omeprazole of recent studies in recent years exploitation wherein, its mechanism of action is different from traditional bisfentidine, but suppresses the secreted microtubule of parietal cell top film formation and the H on the intracytoplasmic tubular foam specifically
+-K
+-ATP enzyme, thereby the secretion of gastric acid inhibitory effectively.Because H
+-K
+-ATP enzyme is last process that parietal cell secretes acid, therefore omeprazole to press down sour ability strong, can not only suppress the gastric acid secretion that gastrin, histamine, choline and food, vagus nerve stimulation etc. cause by noncompetitive, and can suppress the part basal gastric acid secretion that not influenced by choline or H2 receptor blocking agent, stimulate the gastric acid secretion that causes that strong and persistent inhibitory action is also arranged to bisfentidine is untamed by the dibutyl cyclic adenosine monophosphate, and pepsinia is also had inhibitory action.Therefore, the acid effect that presses down of omeprazole obviously and also onset rapid, be widely used in gastric and duodenal ulcers clinically, reflux esophagitis and gastrinoma become " authority " medicine of a new generation's treatment peptic ulcer, gastritis.But the chemicals of this class treatment peptic ulcer inevitably has significantly untoward reaction and easily recurrence such as headache, diarrhoea, erythra, hepatic injury, the feature that need take for a long time.
By contrast, the modern preparation of Chinese medicine prescription and Chinese medicine thereof has low untoward reaction, safety, eutherapeutic characteristics because of the theoretical prescription of its unique tcm treatment according to syndrome differentiation.
Summary of the invention
The purpose of this invention is to provide a kind of is the medicine of treatment stomach, duodenal ulcer and the chronic gastritis of crude drug preparation with Chinese medicine.This medicine can reduce the ulcer recurrence rate dramatically, and is evident in efficacy.
The medicine of treatment ulcer of the present invention and chronic gastritis is that the Chinese medicine by following portions by weight is that crude drug is made:
System Concha Arcae 200～300 Olibanum (processed)s 150～200 Myrrha (processed)s 150～200
The preferred crude drug component of medicine of the present invention (parts by weight) is:
System Concha Arcae 250 Olibanum (processed)s 175 Myrrha (processed)s 175
Said medicine can be made any solid orally ingestible on the pharmaceutics, as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is a capsule.
The concrete preparation method of medicine of the present invention is:
Get the crude drug of above-mentioned parts by weight, be ground into no granular sensation fine powder behind the mix homogeneously, make solid orally ingestible according to conventional operation.
Concha Arcae is sweet salty, flat, and the expectorant blood stasis dispelling is arranged, hard masses softening and resolving, and the function of relieving gastric hyperacidity to alleviate stomachache cures mainly stomachache acid regurgitation, old accumulation of phlegm and disease such as gathers.
Modern medicine study shows that Olibanum can effectively be killed helicobacter pylori external, and Myrrha extract has very strong analgesic activity, the two mutual reinforcement between and usefulness has good blood stasis dispelling, pain relieving, tissue regeneration promoting effect.
Motherland's traditional medical theory thinks that stomach is a reservoir of food and drink, is received, digesting food, moistening foster whole body, is usefulness to lead to, Wood restricts earth, hyperactive liver-QI attacking the stomach, catharsis mistake department, failure of stomach-QI to descend is singultus then, being received becomes thoroughly decomposed haves no right then noisy, acid regurgitation, poor appetite, FU QI being obstructed is then had a stomachache, and with the passing of time disease prolongs, and then gives birth to the expectorant stasis of blood, then the disease delay is difficult for phlegm-coagulation and blood-stagnation, Shen Sheng mass in the abdomen.Prescription of the present invention is monarch with the system Concha Arcae, returns stomach, Liver Channel, suppressing the hyperactive liver and easing the stomach, and relieving gastric hyperacidity to alleviate stomachache, eliminating phlegm and softening indurated mass, blood stasis-eliminating and stagnation-dissipating, minister is transferred liver reason spleen, promoting blood circulation and stopping pain, detumescence and promoting granulation with Olibanum (processed), Myrrha (processed).The present invention starts with from transferring the liver stomach function regulating, and the expectorant dissipating blood stasis is the plan of effecting a permanent cure, and makes the Concha Arcae relieving gastric hyperacidity to alleviate stomachache again, closes Olibanum (processed), Myrrha (processed) promoting blood circulation and stopping pain, at acid, the treatment of pain primary symptom, treating both the principal and the secondary aspects of a disease at the same time, the merit of complex stomach.So indication of the present invention is a traditional gastric abscess card, promptly modern stomach, peptic ulcer of duodenum and chronic gastritis etc. in clinical.
The usage and dosage of medicine of the present invention:
1～1.5 hour after the meal oral, and every day 2～3 times, each 3～4,7 days is a course of treatment.
Pharmacology teaching and research room of Mountain Western Medicine S University uses the capsule preparations of medicine of the present invention to carry out rat experimental gastric ulcer influence research, research conclusion is thought: after rat is irritated stomach capsule preparations of the present invention in advance, can suppress the formation of indometacin ulcer, reserpine ulcer and ligation pyloric ulcer, dwindle the area and the volume of acetic acid ulcer, its suppression ratio is respectively 56%, 83%, 50%, 83% and 94%.
The specific embodiment
Embodiment 1
To make 2000, specification is that the capsule of 0.4g/ grain is an example, prepares raw material of Chinese medicine by following weight:
System Concha Arcae 250g Olibanum (processed) 175g Myrrha (processed) 175g.
Medical material selected, above-mentioned weight after handling by pharmacopeia Chinese medicine processing method is evenly mixed, pulverize the fine powder that touches no granular sensation for hands, in incapsulating by the specification of 0.4g/ grain, make about 2000 of capsule altogether.
Application examples
Select 164 routine stomaches, duodenal ulcer and chronic gastritis (being traditional Chinese medical science gastric abscess) patient at random, each 82 example of stomach, duodenal ulcer patients and chronic gastritis patient are wherein observed the clinical efficacy that uses behind the medicine of the present invention.
In the 164 routine cases, minimum 20 years old of age, maximum 70 years old; The course of disease is the shortest 2 months, and is the longest 34 years.All cases are all with reference to People's Republic of China's Chinese medicine industry standard---and the diagnostic criteria of the gastric abscess that traditional Chinese medical science disease diagnosis criterion of therapeutical effect (ZY/T001.1-94) is formulated is diagnosed.
MethodsThe cases enrolled adopts medicine of the present invention, 1～1.5 hour after the meal oral the treatment, and 7 days is a course of treatment, is generally 1～2 course of treatment.
Efficacy assessment standard: cure: gastric abscess and other transference cure, X line canel barium meal contrast examination or gastroscopy are normal.Take a turn for the better: stomachache is alleviated, and attack times reduces, other sxs, and X line canel barium meal contrast examination or gastroscopy take a favorable turn.Do not heal: symptom does not have improvement, X line canel barium meal contrast examination or gastroscopy no change.
The results are shown in Table 1 after going into to organize the case treatment.
Table 1 goes into to organize case treatment back efficacy result
Model case
Example 1: Shanxi province Taiyuan city Zhao, the man, 37 years old, cause stomachache, acid regurgitation even haematemesis because of drinking for a long time, be gastric ulcer through looking into, once used " SANJIU WEITAI ", " SIDASHU ", " omeprazole " etc., but because of daily health maintenance can't take into account, so cause above-mentioned medication curative effect to weaken to invalid.After take capsule preparations of the present invention, very fast pain relieving, antacid, the logotype medicine is promptly fully recovered for 2 courses of treatment.
Example 2: Mentougou, Beijing City district Tan, dead in 2007 with 84 years old advanced age, Tan suffers from gastric ulcer in the time of 50 years old, stomachache, acid regurgitation, one even can not take food in three or four days when being in a bad way, and all was to control the repetition offence repeatly with multiple Pharmaceuticals treatment, medicament powder of the present invention is attempted taking in the back, serve on 12 days, recover, and before dead, do not recur again.
Example 3: Yuncheng, Shanxi city Lu, 70 years old, suffer from duodenal ulcer disease, taking import medicine numerous medicines such as " bismuth aluminate compound ", also is not heal for many years, attempts taking capsule preparations of the present invention after medical courses in general big friend in Shanxi introduces, in two weeks of logotype, the Peptic Ulcers healing was not recurred in 13 years so far.
Example 4: the retirement professor Zheng of Lanzhou University, suffer from superficial gastritis for many years, stomachache all the year round, flatulence, acid regurgitation, constipation take medicine that it is invalid to control repeatly, after take capsule preparations of the present invention, symptom alleviates very soon, the thoroughly recovery from illness rehabilitations of two week of logotype back.
Claims (4)
1. medicine that is used for the treatment of ulcer and chronic gastritis is that the Chinese medicine by following portions by weight is that crude drug is made:
System Concha Arcae 200～300 Olibanum (processed)s 150～200 Myrrha (processed)s 150～200.
2. the medicine that is used for the treatment of ulcer and chronic gastritis according to claim 1 is characterized in that preferred raw material medicines in portions by weight number is:
System Concha Arcae 250 Olibanum (processed)s 175 Myrrha (processed)s 175.
3. the described preparation method that is used for the treatment of the medicine of ulcer and chronic gastritis of claim 1 is got the crude drug of above-mentioned parts by weight, is ground into fine powder behind the mix homogeneously, makes solid orally ingestible according to conventional operation.
4. the preparation method that is used for the treatment of the medicine of ulcer and chronic gastritis according to claim 3 is characterized in that described medicine is made capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910075703A CN101693048A (en) | 2009-10-12 | 2009-10-12 | Medicament for treating ulcer and chronic gastritis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910075703A CN101693048A (en) | 2009-10-12 | 2009-10-12 | Medicament for treating ulcer and chronic gastritis |
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| CN101693048A true CN101693048A (en) | 2010-04-14 |
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|---|---|---|---|
| CN200910075703A Pending CN101693048A (en) | 2009-10-12 | 2009-10-12 | Medicament for treating ulcer and chronic gastritis |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102949660A (en) * | 2012-10-25 | 2013-03-06 | 安徽金太阳生化药业有限公司 | Traditional Chinese medicine powder for treating atrophic gastritis and preparation method thereof |
| CN104547542A (en) * | 2014-12-24 | 2015-04-29 | 张冬 | Traditional Chinese medicinal preparation for treating peptic ulcer and method for preparing preparation |
| CN107412543A (en) * | 2017-06-30 | 2017-12-01 | 张登晶 | It is a kind of to treat gastric ulcer, the Chinese medicine preparation of duodenal bulbar ulcer |
| CN107890009A (en) * | 2017-11-25 | 2018-04-10 | 明光市绿园粮油贸易有限公司 | A kind of flour for treating chronic gastritis and preparation method thereof |
-
2009
- 2009-10-12 CN CN200910075703A patent/CN101693048A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102949660A (en) * | 2012-10-25 | 2013-03-06 | 安徽金太阳生化药业有限公司 | Traditional Chinese medicine powder for treating atrophic gastritis and preparation method thereof |
| CN102949660B (en) * | 2012-10-25 | 2014-05-14 | 安徽金太阳生化药业有限公司 | Traditional Chinese medicine powder for treating atrophic gastritis and preparation method thereof |
| CN104547542A (en) * | 2014-12-24 | 2015-04-29 | 张冬 | Traditional Chinese medicinal preparation for treating peptic ulcer and method for preparing preparation |
| CN107412543A (en) * | 2017-06-30 | 2017-12-01 | 张登晶 | It is a kind of to treat gastric ulcer, the Chinese medicine preparation of duodenal bulbar ulcer |
| CN107890009A (en) * | 2017-11-25 | 2018-04-10 | 明光市绿园粮油贸易有限公司 | A kind of flour for treating chronic gastritis and preparation method thereof |
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Application publication date: 20100414 |