CN105748809A - Narcotic analgesic medicament and manufacturing method thereof - Google Patents
Narcotic analgesic medicament and manufacturing method thereof Download PDFInfo
- Publication number
- CN105748809A CN105748809A CN201610072640.2A CN201610072640A CN105748809A CN 105748809 A CN105748809 A CN 105748809A CN 201610072640 A CN201610072640 A CN 201610072640A CN 105748809 A CN105748809 A CN 105748809A
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- herba
- radix
- narcotic analgesic
- ramulus
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Abstract
The invention discloses a narcotic analgesic medicament and a manufacturing method thereof, and belongs to the field of traditional Chinese medicaments. The active ingredients of the narcotic analgesic medicament disclosed by the invention are the following raw materials: cassia bark, Sichuan pepper, cyperus rotundus, saffron, primula efarinosa pax, asarum, ephedra herb, garden balsam stem, rhizoma acori graminei, mint, licorice root, cryptotaenia japonica, angelica dahurica, fructus piperis longi, debregeasia orientalis, pseudo-ginseng root, chamomile, fineleaf schizonepeta herb, tangerine peel and rubia cordifolia. According to the medicament disclosed by the invention, the selected medicinal materials are appropriate in compatibility and meet the theories of traditional Chinese medicine and pharmacy and modern medicine and pharmacy; the narcotic analgesic medicament has the effects of narcotizing, activating blood and dissolving stasis, and diminishing inflammation and relieving pain, is good in treatment effect, quick in response, convenient to take, safe and reliable and low in cost, does not have any toxic or side effects and can quickly and effectively relieve the pain of a patient in an operation, so that the narcotic analgesic medicament is worth to be widely applied clinically.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, particularly relate to a kind of narcotic analgesic medicine and preparation method thereof.
Background technology
From medical angle, anesthesia is meant that and makes patient overall by medicine or additive method or be locally temporarily lost with sensation, to reach painless purpose, offer condition is treated for operative treatment or other medical examination, in clinical operation, especially, in the operation of local anesthesia, it is required for using anesthetics.At present, it is common to adopt the injection anesthetis such as Western medicine procaine and benefit card or adopt the method for conduction block to anaesthetize, or carrying out topical anesthesia by pad pasting.These anesthesia methods adopted now, although having certain therapeutic effect, but but there is slow curative effect, medical expense is high, toxic and side effects is big shortcoming, not only complex operation, and narcotic consumption is had strict requirement, injection deficiency, do not have good anaesthetic effect, inject excessive then can to the brain of human body, nervous system produce harmful effect.Therefore the development of Chinese medicine class narcotic analgesic medicine is more and more meaningful.
Distinguish the mechanism controlling pain card about Chinese drug anesthesia analgesic, can be concluded from the following aspects: (one) pungent temperature dredging collateral, promoting blood circulation and stopping pain.The how pungent temperature of Chinese drug anesthesia analgesic abnormal smells from the patient, the cause of disease of pain is no doubt complicated, but no matter what because of, all cause meridians and intercept, muscle arteries and veins defeats, and stasis is obstructed.Even heat syndrome also has hot Kui venation, stagnant and obstructed fraud, so-called stagnation of QI and blood may bring about pain.Right pungent energy dissipates can manage it, Wen Nengshu fishing venation, and venation is got profit, and QI and blood passes unimpeded, and pain is from washing.(2) giving treatment in accordance with the tendency of pathological change, captures it long.Chinese drug anesthesia analgesic, its nature,taste and action differs from one another, and clinical practice is wanted giving treatment in accordance with the tendency of pathological change, captured its length.
Summary of the invention
For the deficiencies in the prior art, the invention provides a kind of narcotic analgesic medicine, there is significant curative effect and instant effect, taking convenience, safe and reliable advantage.
For realizing object above, the present invention is achieved by the following technical programs:
A kind of narcotic analgesic medicine, is made up of the raw material of following weight portion: 20～30 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 8～15 parts of Pericarpium Zanthoxyli, Rhizoma Cyperi 6～10 parts, Stigma Croci 5～10 parts, cloud sedge 1～5 part, Herba Asari 2～6 parts, 1～7 part of Herba Ephedrae, Herba speranskiae tuberculatae 2～10 parts, Rhizoma Acori Graminei 6～10 parts, Herba Menthae 6～12 parts, 5～10 parts of Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae 4～10 parts, the Radix Angelicae Dahuricae 3～8 parts, Fructus Piperis Longi 4～8 parts, Ramulus et Folium Debregeasiae Edulis 6～10 parts, Radix Notoginseng 5～10 parts, Flos Matricariae chamomillae 6～12 parts, Herba Schizonepetae 4～8 parts, Pericarpium Citri Reticulatae 3～7 parts, 4～8 parts of Radix Rubiae.
Preferably, described narcotic analgesic medicine is made up of the raw material of following weight portion: 22～28 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 10～13 parts of Pericarpium Zanthoxyli, Rhizoma Cyperi 5～9 parts, Stigma Croci 6～8 parts, cloud sedge 2～4 parts, Herba Asari 3～6 parts, 2～6 parts of Herba Ephedrae, Herba speranskiae tuberculatae 3～9 parts, Rhizoma Acori Graminei 7～9 parts, Herba Menthae 5～10 parts, 6～8 parts of Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae 5～8 parts, the Radix Angelicae Dahuricae 4～7 parts, Fructus Piperis Longi 5～7 parts, Ramulus et Folium Debregeasiae Edulis 7～9 parts, Radix Notoginseng 6～8 parts, Flos Matricariae chamomillae 7～11 parts, Herba Schizonepetae 5～7 parts, Pericarpium Citri Reticulatae 4～6 parts, 5～9 parts of Radix Rubiae.
Preferably, described narcotic analgesic medicine is made up of the raw material of following weight portion: 23 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 10 parts of Pericarpium Zanthoxyli, Rhizoma Cyperi 5 parts, Stigma Croci 6 parts, cloud sedge 3 parts, Herba Asari 3 parts, 3 parts of Herba Ephedrae, Herba speranskiae tuberculatae 4 parts, Rhizoma Acori Graminei 7 parts, Herba Menthae 7 parts, 6 parts of Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae 5 parts, the Radix Angelicae Dahuricae 4 parts, Fructus Piperis Longi 5 parts, Ramulus et Folium Debregeasiae Edulis 7 parts, Radix Notoginseng 6 parts, Flos Matricariae chamomillae 6 parts, Herba Schizonepetae 5 parts, Pericarpium Citri Reticulatae 4 parts, 5 parts of Radix Rubiae.
Preferably, described narcotic analgesic medicine is made up of the raw material of following weight portion: 25 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 12 parts of Pericarpium Zanthoxyli, Rhizoma Cyperi 6 parts, Stigma Croci 7 parts, cloud sedge 4 parts, Herba Asari 4 parts, 4 parts of Herba Ephedrae, Herba speranskiae tuberculatae 5 parts, Rhizoma Acori Graminei 8 parts, Herba Menthae 9 parts, 8 parts of Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae 6 parts, the Radix Angelicae Dahuricae 5 parts, Fructus Piperis Longi 6 parts, Ramulus et Folium Debregeasiae Edulis 8 parts, Radix Notoginseng 6 parts, Flos Matricariae chamomillae 8 parts, Herba Schizonepetae 5 parts, Pericarpium Citri Reticulatae 4 parts, 8 parts of Radix Rubiae.
The manufacture method of narcotic analgesic medicine, comprises the following steps that:
(1) first weigh a certain proportion of Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Zanthoxyli, Rhizoma Cyperi, Stigma Croci, cloud sedge, Herba Asari are then placed in pulverizer, carry out pulverization process, grind the fine powder crossing 180 orders afterwards into powder, standby；
(2) a certain proportion of Herba Ephedrae, Herba speranskiae tuberculatae, Rhizoma Acori Graminei, Herba Menthae, Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae, the Radix Angelicae Dahuricae, Fructus Piperis Longi, Ramulus et Folium Debregeasiae Edulis are weighed, then clean, the alcohol solution dipping of the 80% of immersion 5～6 times amount 1～2 hour, heating extraction 3 hours, reclaim ethanol, filtering to get filtrate, finally concentration is thick paste, standby；
(3) weigh a certain proportion of Radix Notoginseng, Flos Matricariae chamomillae, Herba Schizonepetae, Pericarpium Citri Reticulatae, Radix Rubiae, put into container, add the distilled water of 8～10 times amount, after soaking 5～6 hours, decoct 3～4 hours, filter, obtain filtering residue and extracting solution；In filtering residue, again add 6～8 times amount distilled water, decoct 2～3 hours, extract；Finally, add 4～6 times amount distilled water, heated and boiled 1～2 hour, extract；Merge three extracting solution, filter to get filtrate, concentrate thick paste, standby；
(4) thick for the fine powder obtained by above-mentioned steps (1)～(3), cream and juice are mixed, make tablet, obtain the medicine of described treatment narcotic analgesic.
In the present invention, effect of each raw material is as follows:
Cortex cinnamomi japonici (Ramulus Cinnamomi): extremely hot in nature, acrid in the mouth, sweet, to return kidney, spleen, the heart, Liver Channel, there is benefit fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, effect of promoting blood circulation to restore menstrual flow, for warming the spleen and stomach, removing accumulated cold, promoting blood circulation.
Pericarpium Zanthoxyli: pungent, temperature, enter spleen, lung, kidney channel.Function cures mainly: warming spleen and stomach for dispelling cold, dehumidifying, pain relieving, parasite killing, solves fish raw meat poison.Control food stagnation and stop drink, trusted subordinate's cold type of pain, vomit, oh, cough with dyspnea, anemofrigid-damp arthralgia, have loose bowels, dysentery, colic, toothache.
Rhizoma Cyperi: hardship pungent, micro-, micro-sweet is flat.Return liver, spleen, tri-jiao channel.Function cures mainly: promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Stigma Croci: sweet in the mouth, property is put down, energy blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens, pain relieving.For treating troubled thoughts pent-up, chest and diaphragm painful abdominal mass is vexed, spits blood, and typhoid fever is gone mad, and blood stasis is had a pain, measles, traumatic injury etc..
Cloud sedge: bitter in the mouth, pungent, property is put down, and has expelling wind and removing dampness, and effect of removing toxic substances and promoting subsidence of swelling cures mainly cold, fever, cough, laryngopharynx swelling and pain, toothache, rheumatic arthralgia, hepatitis, dysentery, skin pruritus, venom etc..
Herba Asari: acrid in the mouth, warm in nature, return lung, kidney channel, there is expelling wind and cold pain relieving, effect that warming the lung to resolve fluid-retention is sensible, cure mainly affection of exogenous wind-cold, headache, toothache, wind and cold temperature numbness, affection of exogenous wind-cold, in stop lung cold cough with asthma caused by cold fluid-retention.
Herba Ephedrae: acrid in the mouth, micro-hardship, warm in nature, enter lung, bladder warp, have and send out cold inducing sweat, depressed lung-energy dispersing, the effect of inducing diuresis to remove edema, be mainly used in the exterior excess syndrome such as fever without perspiration of affection of exogenous wind-cold；Rheumatic arthralgia pain, cough with asthma QI rising in reverse order, edema, dysuria etc..
Herba speranskiae tuberculatae: sweet in the mouth, pungent, warm in nature, enter lung, liver two warp, there is expelling wind and removing dampness, effect of removing toxic substances pain relieving, be used for treating rheumatic arthritis.
Rhizoma Acori Graminei: acrid in the mouth, warm in nature, enter the heart, stomach warp, there is refreshment of having one's ideas straightened out, effect of removing dampness to restore normal function of the stomach, it is used for treating expectorant and covers clear key, coma is demented, dizzy, and insomnia is forgetful, tinnitus, retention of dampness in middle-JIAO, abdominal distention etc..
Herba Menthae: acrid in the mouth, cool in nature, enter lung meridian, Liver Channel.For anemopyretic cold, epidemic febrile disease from the beginning of.These product are pungent to disperse, cool to heat clearing away, and clear light cool scattered, Herba Menthae has antivirus action, analgesia, itching-relieving action, irritation, antitussive action, bactericidal action, antibacterial action, effect of relieveing pain and refreshing, can alleviate headache, migraine and toothache.
Radix Glycyrrhizae: sweet in the mouth, property is put down, and enters 12 warps, has a heat-clearing and toxic substances removing, is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, be mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak；Alleviating contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play QI invigorating neutralize by adding Radix Glycyrrhizae, is in harmonious proportion the effect of each component.
Caulis et folium cryptotaeniae japonicae: acrid in the mouth is bitter；Property is put down, and has dispelling wind stopping cough；Eliminating damp, detoxifying；Effect of blood-activating analgetic, cures mainly pneumonia, pulmonary abscess, gonorrhea, hernia, acute toothache, and carbuncle furuncle swells, herpes zoster, skin pruritus etc..
The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature, enter lung, spleen, stomach warp, there is the cold expelling that induces sweat, wind-expelling pain-stopping, dampness leukorrhagia stopping, effect of detumescence and apocenosis, cure mainly headache, supraorbital bone pain, toothache, cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, skin pruritus due to dryness, scabies etc..
Fructus Piperis Longi: acrid in the mouth, hot in nature, returns stomach, large intestine channel, has warming spleen and stomach for dispelling cold, effect of therapeutic method to keep the adverse QI flowing downwards pain relieving, cures mainly coldness and pain in the epigastrium, vomits singultus, dysentery, headache, toothache, nasal sinusitis etc..
Ramulus et Folium Debregeasiae Edulis: for the branch and leaf of Urticaceae Debregeasia orientalis C. J. Chen platymiscium Debregeasia orientalis C. J. Chen, acrid in the mouth, micro-hardship, cool in nature, there is dispelling wind cough-relieving, clearing heat for promoting eruption, effect of removing stasis to stop bleeding, cure mainly exogenous cough, hemoptysis, acute infantile convulsion wind, measles without adequate eruption, traumatic injury, enclosed mass etc. in women's abdomen.
Radix Notoginseng: sweet in the mouth, micro-hardship, warm in nature, enter liver, stomach warp, have hemostasia and dissipation blood stasis, the effect of reducing swelling and alleviating pain；Protect the liver, antiinflammatory.
Flos Matricariae chamomillae: anxiety, anxiety, indignation and fear can be alleviated, make people loosen；There is the function of pain relieving simultaneously.Myalgia can be relaxed, especially because of the nervous pain caused.
Herba Schizonepetae: acrid in the mouth, micro-hardship, property is micro-wet；Enter lung, Liver Channel.Cure mainly cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain, measles, carbuncle, skin ulcer scabies, puerperal blood faints.
Pericarpium Citri Reticulatae: bitter in the mouth, pungent, warm in nature.Return lung, spleen channel.There is regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm.
Radix Rubiae: cold in nature, bitter in the mouth, return Liver Channel, effect: cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling, cure mainly, traumatic injury, rheumatic arthralgia, jaundice, carbuncle sore, hemorrhoid are swollen.The antitussive action of Radix Rubiae is relatively strong, eliminates the phlegm, relievings asthma and take second place, and has certain antiinflammation.
The method have the benefit that
Selected by medicine of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, play effect of anesthesia, blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic altogether, and good effect, instant effect, taking convenience, safe and reliable, without any side effects, the misery in patient's operation can be alleviated fast and effectively, with low cost, wide popularization and application on clinic.The narcotic analgesic medicine processing technology of the present invention is simply efficient, it is possible to makes the curative effect of medicine maximize to the greatest extent performance, saves cost.
Detailed description of the invention
For making the purpose of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with embodiments of the invention, the technical scheme in the embodiment of the present invention is clearly and completely described.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art obtain under not making creative work premise, broadly fall into the scope of protection of the invention.
Embodiment 1:
A kind of narcotic analgesic medicine, raw material composition and the mass fraction of making effective ingredient be: 23 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 10 parts of Pericarpium Zanthoxyli, Rhizoma Cyperi 5 parts, Stigma Croci 6 parts, cloud sedge 3 parts, Herba Asari 3 parts, 3 parts of Herba Ephedrae, Herba speranskiae tuberculatae 4 parts, Rhizoma Acori Graminei 7 parts, Herba Menthae 7 parts, 6 parts of Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae 5 parts, the Radix Angelicae Dahuricae 4 parts, Fructus Piperis Longi 5 parts, Ramulus et Folium Debregeasiae Edulis 7 parts, Radix Notoginseng 6 parts, Flos Matricariae chamomillae 6 parts, Herba Schizonepetae 5 parts, Pericarpium Citri Reticulatae 4 parts, 5 parts of Radix Rubiae.
Manufacture method is:
(1) first weigh a certain proportion of Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Zanthoxyli, Rhizoma Cyperi, Stigma Croci, cloud sedge, Herba Asari are then placed in pulverizer, carry out pulverization process, grind the fine powder crossing 180 orders afterwards into powder, standby；
(2) a certain proportion of Herba Ephedrae, Herba speranskiae tuberculatae, Rhizoma Acori Graminei, Herba Menthae, Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae, the Radix Angelicae Dahuricae, Fructus Piperis Longi, Ramulus et Folium Debregeasiae Edulis are weighed, then clean, immerse 5 times amount 80% alcohol solution dipping 1 hour, heating extraction 3 hours, reclaim ethanol, filtering to get filtrate, finally concentration is thick paste, standby；
(3) weigh a certain proportion of Radix Notoginseng, Flos Matricariae chamomillae, Herba Schizonepetae, Pericarpium Citri Reticulatae, Radix Rubiae, put into container, add the distilled water of 8 times amount, after soaking 5 hours, decoct 3 hours, filter, obtain filtering residue and extracting solution；In filtering residue, again add 6 times amount distilled water, decoct 2 hours, extract；Finally, add 4 times amount distilled water, heated and boiled 2 hours, extract；Merge three extracting solution, filter to get filtrate, concentrate thick paste, standby；
(4) thick for the fine powder obtained by above-mentioned steps (1)～(3), cream and juice are mixed, make tablet, obtain the medicine of described treatment narcotic analgesic.
Embodiment 2:
A kind of narcotic analgesic medicine, raw material composition and the mass fraction of making effective ingredient be: 25 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 12 parts of Pericarpium Zanthoxyli, Rhizoma Cyperi 6 parts, Stigma Croci 7 parts, cloud sedge 4 parts, Herba Asari 4 parts, 4 parts of Herba Ephedrae, Herba speranskiae tuberculatae 5 parts, Rhizoma Acori Graminei 8 parts, Herba Menthae 9 parts, 8 parts of Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae 6 parts, the Radix Angelicae Dahuricae 5 parts, Fructus Piperis Longi 6 parts, Ramulus et Folium Debregeasiae Edulis 8 parts, Radix Notoginseng 6 parts, Flos Matricariae chamomillae 8 parts, Herba Schizonepetae 5 parts, Pericarpium Citri Reticulatae 4 parts, 8 parts of Radix Rubiae.
(1) first weigh a certain proportion of Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Zanthoxyli, Rhizoma Cyperi, Stigma Croci, cloud sedge, Herba Asari are then placed in pulverizer, carry out pulverization process, grind the fine powder crossing 180 orders afterwards into powder, standby；
(2) a certain proportion of Herba Ephedrae, Herba speranskiae tuberculatae, Rhizoma Acori Graminei, Herba Menthae, Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae, the Radix Angelicae Dahuricae, Fructus Piperis Longi, Ramulus et Folium Debregeasiae Edulis are weighed, then clean, immerse 6 times amount 80% alcohol solution dipping 2 hours, heating extraction 3 hours, reclaim ethanol, filtering to get filtrate, finally concentration is thick paste, standby；
(3) weigh a certain proportion of Radix Notoginseng, Flos Matricariae chamomillae, Herba Schizonepetae, Pericarpium Citri Reticulatae, Radix Rubiae, put into container, add the distilled water of 9 times amount, after soaking 5 hours, decoct 3 hours, filter, obtain filtering residue and extracting solution；In filtering residue, again add 6 times amount distilled water, decoct 2 hours, extract；Finally, add 4 times amount distilled water, heated and boiled 1 hour, extract；Merge three extracting solution, filter to get filtrate, concentrate thick paste, standby；
(4) thick for the fine powder obtained by above-mentioned steps (1)～(3), cream and juice are mixed, make tablet, obtain the medicine of described treatment narcotic analgesic.
Embodiment 3:
A kind of narcotic analgesic medicine, raw material composition and the mass fraction of making effective ingredient be: 26 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 11 parts of Pericarpium Zanthoxyli, Rhizoma Cyperi 8 parts, Stigma Croci 7 parts, cloud sedge 4 parts, Herba Asari 4 parts, 4 parts of Herba Ephedrae, Herba speranskiae tuberculatae 5 parts, Rhizoma Acori Graminei 8 parts, Herba Menthae 9 parts, 6 parts of Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae 6 parts, the Radix Angelicae Dahuricae 6 parts, Fructus Piperis Longi 6 parts, Ramulus et Folium Debregeasiae Edulis 8 parts, Radix Notoginseng 6 parts, Flos Matricariae chamomillae 8 parts, Herba Schizonepetae 5 parts, Pericarpium Citri Reticulatae 5 parts, 7 parts of Radix Rubiae.
(1) first weigh a certain proportion of Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Zanthoxyli, Rhizoma Cyperi, Stigma Croci, cloud sedge, Herba Asari are then placed in pulverizer, carry out pulverization process, grind the fine powder crossing 180 orders afterwards into powder, standby；
(2) a certain proportion of Herba Ephedrae, Herba speranskiae tuberculatae, Rhizoma Acori Graminei, Herba Menthae, Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae, the Radix Angelicae Dahuricae, Fructus Piperis Longi, Ramulus et Folium Debregeasiae Edulis are weighed, then clean, immerse 5 times amount 80% alcohol solution dipping 1.5 hours, heating extraction 3 hours, reclaim ethanol, filtering to get filtrate, finally concentration is thick paste, standby；
(3) weigh a certain proportion of Radix Notoginseng, Flos Matricariae chamomillae, Herba Schizonepetae, Pericarpium Citri Reticulatae, Radix Rubiae, put into container, add the distilled water of 9 times amount, after soaking 6 hours, decoct 3 hours, filter, obtain filtering residue and extracting solution；In filtering residue, again add 6～8 times amount distilled water, decoct 2 hours, extract；Finally, add 4 times amount distilled water, heated and boiled 1 hour, extract；Merge three extracting solution, filter to get filtrate, concentrate thick paste, standby；
(4) thick for the fine powder obtained by above-mentioned steps (1)～(3), cream and juice are mixed, make tablet, obtain the medicine of described treatment narcotic analgesic.
Embodiment 4:
A kind of narcotic analgesic medicine, raw material composition and the mass fraction of making effective ingredient be: 26 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 11 parts of Pericarpium Zanthoxyli, Rhizoma Cyperi 7 parts, Stigma Croci 7 parts, cloud sedge 4 parts, Herba Asari 4 parts, 5 parts of Herba Ephedrae, Herba speranskiae tuberculatae 6 parts, Rhizoma Acori Graminei 9 parts, Herba Menthae 9 parts, 8 parts of Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae 7 parts, the Radix Angelicae Dahuricae 5 parts, Fructus Piperis Longi 6 parts, Ramulus et Folium Debregeasiae Edulis 8 parts, Radix Notoginseng 7 parts, Flos Matricariae chamomillae 8 parts, Herba Schizonepetae 7 parts, Pericarpium Citri Reticulatae 4 parts, 8 parts of Radix Rubiae.
(1) first weigh a certain proportion of Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Zanthoxyli, Rhizoma Cyperi, Stigma Croci, cloud sedge, Herba Asari are then placed in pulverizer, carry out pulverization process, grind the fine powder crossing 180 orders afterwards into powder, standby；
(2) a certain proportion of Herba Ephedrae, Herba speranskiae tuberculatae, Rhizoma Acori Graminei, Herba Menthae, Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae, the Radix Angelicae Dahuricae, Fructus Piperis Longi, Ramulus et Folium Debregeasiae Edulis are weighed, then clean, immerse 5 times amount 80% alcohol solution dipping 1 hour, heating extraction 3 hours, reclaim ethanol, filtering to get filtrate, finally concentration is thick paste, standby；
(3) weigh a certain proportion of Radix Notoginseng, Flos Matricariae chamomillae, Herba Schizonepetae, Pericarpium Citri Reticulatae, Radix Rubiae, put into container, add the distilled water of 8 times amount, after soaking 6 hours, decoct 4 hours, filter, obtain filtering residue and extracting solution；In filtering residue, again add 6 times amount distilled water, decoct 2 hours, extract；Finally, add 5 times amount distilled water, heated and boiled 1 hour, extract；Merge three extracting solution, filter to get filtrate, concentrate thick paste, standby；
(4) thick for the fine powder obtained by above-mentioned steps (1)～(3), cream and juice are mixed, make tablet, obtain the medicine of described treatment narcotic analgesic.
Embodiment 5:
A kind of narcotic analgesic medicine, raw material composition and the mass fraction of making effective ingredient be: 27 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 12 parts of Pericarpium Zanthoxyli, Rhizoma Cyperi 6 parts, Stigma Croci 7 parts, cloud sedge 4 parts, Herba Asari 5 parts, 4 parts of Herba Ephedrae, Herba speranskiae tuberculatae 6 parts, Rhizoma Acori Graminei 8 parts, Herba Menthae 9 parts, 8 parts of Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae 6 parts, the Radix Angelicae Dahuricae 5 parts, Fructus Piperis Longi 6 parts, Ramulus et Folium Debregeasiae Edulis 9 parts, Radix Notoginseng 6 parts, Flos Matricariae chamomillae 8 parts, Herba Schizonepetae 5 parts, Pericarpium Citri Reticulatae 5 parts, 8 parts of Radix Rubiae.
(1) first weigh a certain proportion of Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Zanthoxyli, Rhizoma Cyperi, Stigma Croci, cloud sedge, Herba Asari are then placed in pulverizer, carry out pulverization process, grind the fine powder crossing 180 orders afterwards into powder, standby；
(2) a certain proportion of Herba Ephedrae, Herba speranskiae tuberculatae, Rhizoma Acori Graminei, Herba Menthae, Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae, the Radix Angelicae Dahuricae, Fructus Piperis Longi, Ramulus et Folium Debregeasiae Edulis are weighed, then clean, immerse 6 times amount 80% alcohol solution dipping 2 hours, heating extraction 3 hours, reclaim ethanol, filtering to get filtrate, finally concentration is thick paste, standby；
(3) weigh a certain proportion of Radix Notoginseng, Flos Matricariae chamomillae, Herba Schizonepetae, Pericarpium Citri Reticulatae, Radix Rubiae, put into container, add the distilled water of 10 times amount, after soaking 6 hours, decoct 4 hours, filter, obtain filtering residue and extracting solution；In filtering residue, again add 8 times amount distilled water, decoct 3 hours, extract；Finally, add 4 times amount distilled water, heated and boiled 2 hours, extract；Merge three extracting solution, filter to get filtrate, concentrate thick paste, standby；
(4) thick for the fine powder obtained by above-mentioned steps (1)～(3), cream and juice are mixed, make tablet, obtain the medicine of described treatment narcotic analgesic.
Embodiment 6:
A kind of narcotic analgesic medicine, raw material composition and the mass fraction of making effective ingredient be: 24 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 12 parts of Pericarpium Zanthoxyli, Rhizoma Cyperi 6 parts, Stigma Croci 7 parts, cloud sedge 4 parts, Herba Asari 4 parts, 4 parts of Herba Ephedrae, Herba speranskiae tuberculatae 5 parts, Rhizoma Acori Graminei 7 parts, Herba Menthae 9 parts, 8 parts of Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae 6 parts, the Radix Angelicae Dahuricae 4 parts, Fructus Piperis Longi 6 parts, Ramulus et Folium Debregeasiae Edulis 8 parts, Radix Notoginseng 8 parts, Flos Matricariae chamomillae 8 parts, Herba Schizonepetae 6 parts, Pericarpium Citri Reticulatae 6 parts, 8 parts of Radix Rubiae.
(1) first weigh a certain proportion of Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Zanthoxyli, Rhizoma Cyperi, Stigma Croci, cloud sedge, Herba Asari are then placed in pulverizer, carry out pulverization process, grind the fine powder crossing 180 orders afterwards into powder, standby；
(2) a certain proportion of Herba Ephedrae, Herba speranskiae tuberculatae, Rhizoma Acori Graminei, Herba Menthae, Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae, the Radix Angelicae Dahuricae, Fructus Piperis Longi, Ramulus et Folium Debregeasiae Edulis are weighed, then clean, immerse 5 times amount 80% alcohol solution dipping 2 hours, heating extraction 3 hours, reclaim ethanol, filtering to get filtrate, finally concentration is thick paste, standby；
(3) weigh a certain proportion of Radix Notoginseng, Flos Matricariae chamomillae, Herba Schizonepetae, Pericarpium Citri Reticulatae, Radix Rubiae, put into container, add the distilled water of 9 times amount, after soaking 6 hours, decoct 3 hours, filter, obtain filtering residue and extracting solution；In filtering residue, again add 6 times amount distilled water, decoct 2 hours, extract；Finally, add 4 times amount distilled water, heated and boiled 2 hours, extract；Merge three extracting solution, filter to get filtrate, concentrate thick paste, standby；
(4) thick for the fine powder obtained by above-mentioned steps (1)～(3), cream and juice are mixed, make tablet, obtain the medicine of described treatment narcotic analgesic.
Embodiment 7:
A kind of narcotic analgesic medicine, raw material composition and the mass fraction of making effective ingredient be: 28 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 12 parts of Pericarpium Zanthoxyli, Rhizoma Cyperi 6 parts, Stigma Croci 7 parts, cloud sedge 4 parts, Herba Asari 4 parts, 5 parts of Herba Ephedrae, Herba speranskiae tuberculatae 5 parts, Rhizoma Acori Graminei 8 parts, Herba Menthae 9 parts, 8 parts of Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae 6 parts, the Radix Angelicae Dahuricae 5 parts, Fructus Piperis Longi 6 parts, Ramulus et Folium Debregeasiae Edulis 9 parts, Radix Notoginseng 6 parts, Flos Matricariae chamomillae 8 parts, Herba Schizonepetae 7 parts, Pericarpium Citri Reticulatae 4 parts, 9 parts of Radix Rubiae.
(1) first weigh a certain proportion of Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Zanthoxyli, Rhizoma Cyperi, Stigma Croci, cloud sedge, Herba Asari are then placed in pulverizer, carry out pulverization process, grind the fine powder crossing 180 orders afterwards into powder, standby；
(2) a certain proportion of Herba Ephedrae, Herba speranskiae tuberculatae, Rhizoma Acori Graminei, Herba Menthae, Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae, the Radix Angelicae Dahuricae, Fructus Piperis Longi, Ramulus et Folium Debregeasiae Edulis are weighed, then clean, immerse 5 times amount 80% alcohol solution dipping 2 hours, heating extraction 3 hours, reclaim ethanol, filtering to get filtrate, finally concentration is thick paste, standby；
(3) weigh a certain proportion of Radix Notoginseng, Flos Matricariae chamomillae, Herba Schizonepetae, Pericarpium Citri Reticulatae, Radix Rubiae, put into container, add the distilled water of 9 times amount, after soaking 6 hours, decoct 3 hours, filter, obtain filtering residue and extracting solution；In filtering residue, again add 6 times amount distilled water, decoct 2 hours, extract；Finally, add 4 times amount distilled water, heated and boiled 2 hours, extract；Merge three extracting solution, filter to get filtrate, concentrate thick paste, standby；
(4) thick for the fine powder obtained by above-mentioned steps (1)～(3), cream and juice are mixed, make tablet, obtain the medicine of described treatment narcotic analgesic.
Embodiment 8:
A kind of narcotic analgesic medicine, raw material composition and the mass fraction of making effective ingredient be: 28 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 12 parts of Pericarpium Zanthoxyli, Rhizoma Cyperi 6 parts, Stigma Croci 7 parts, cloud sedge 4 parts, Herba Asari 4 parts, 3 parts of Herba Ephedrae, Herba speranskiae tuberculatae 5 parts, Rhizoma Acori Graminei 8 parts, Herba Menthae 9 parts, 8 parts of Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae 6 parts, the Radix Angelicae Dahuricae 5 parts, Fructus Piperis Longi 6 parts, Ramulus et Folium Debregeasiae Edulis 8 parts, Radix Notoginseng 6 parts, Flos Matricariae chamomillae 8 parts, Herba Schizonepetae 5 parts, Pericarpium Citri Reticulatae 5 parts, 8 parts of Radix Rubiae.
(1) first weigh a certain proportion of Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Zanthoxyli, Rhizoma Cyperi, Stigma Croci, cloud sedge, Herba Asari are then placed in pulverizer, carry out pulverization process, grind the fine powder crossing 180 orders afterwards into powder, standby；
(2) a certain proportion of Herba Ephedrae, Herba speranskiae tuberculatae, Rhizoma Acori Graminei, Herba Menthae, Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae, the Radix Angelicae Dahuricae, Fructus Piperis Longi, Ramulus et Folium Debregeasiae Edulis are weighed, then clean, immerse 5 times amount 80% alcohol solution dipping 2 hours, heating extraction 3 hours, reclaim ethanol, filtering to get filtrate, finally concentration is thick paste, standby；
(3) weigh a certain proportion of Radix Notoginseng, Flos Matricariae chamomillae, Herba Schizonepetae, Pericarpium Citri Reticulatae, Radix Rubiae, put into container, add the distilled water of 9 times amount, after soaking 6 hours, decoct 3 hours, filter, obtain filtering residue and extracting solution；In filtering residue, again add 6 times amount distilled water, decoct 2 hours, extract；Finally, add 4 times amount distilled water, heated and boiled 2 hours, extract；Merge three extracting solution, filter to get filtrate, concentrate thick paste, standby；
(4) thick for the fine powder obtained by above-mentioned steps (1)～(3), cream and juice are mixed, make tablet, obtain the medicine of described treatment narcotic analgesic.
Toxicity test:
Application mice 40, male and female half and half, body weight 16～20g, carry out acute toxicity test.Mice is randomly divided into two groups, often group 20, i.e. matched group and administration group, fasting 12 hours before experiment；The tablet 1 prepared by embodiments of the invention 1 is dissolved in water, (concentration is 4.45g crude drug/ml, maximum concentration) gavage, gavage volume is 2ml/kg (namely unit dosage form is 8.9 crude drugs/kg), matched group gives normal saline, one day be administered 1 time, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Test result indicate that: compare with matched group, after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.The indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by Chinese medicine of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 16 weeks and drug withdrawal 4 weeks, Organs of Mice is all without substantially changing.Illustrate that Chinese medicine narcotic substance of the present invention is little to toxicity after mice long-term prescription, react also without difference after drug withdrawal, application safety.
Clinical case:
Case selection:
Taking and derive from the court's dental patients 120 example in October ,-2015 in May, 2014, male 60 examples, female 60 example, in age 18-41 year, wound or odontopathy cause agomphiasis 38 example, residual root of the tooth 44 example, impacted wisdom tooth 38 example.
Anesthesia:
The tablet narcotic analgesic medicine of the embodiment of the present invention 1 preparation is dissolved in distilled water, dips in tweezers clamping cotton balls and is applied in affected part for several times, about 1-3 minute, when checking illing skin tissue analgesia, can perform the operation；Above-mentioned dental patients: periodontal routine disinfection, clamps cotton balls with tweezers and dips in and be applied in this periodontal pocket of having tooth pulled out and in cavities, about 1-3 minute, when checking periodontal tissue's analgesia, cleared out by liniment by swab stick, can implement exodontia.The standard of curative effect evaluation:
Effective: painless or pain is only small in art, without oozing of blood after postoperative 2～8min, edge of wound shrinks, postoperative without accompanying inflammation, recovers to feel in postoperative 2-3h；
Effective: without obvious pain in art, postoperative 2～8min naked eyes are a little oozing of blood as seen, and edge of wound is without obvious contraction, postoperative without accompanying inflammation, recovers sensation in postoperative 2-3h；
Invalid: to have obvious pain or hurt like hell in art, after postoperative 8min, naked eyes are shown in substantially hemorrhage, or produce accompanying inflammation simultaneously.
Therapeutic outcome:
Postoperative anaesthetic effect statistics example (%) of table 1 dental patients
| Patient profiles | Sum | Effective | Effectively | Invalid | Effective percentage |
| Agomphiasis | 38 | 34 | 4 | 0 | 100% |
| Residual root of the tooth | 44 | 39 | 3 | 2 | 95.4% |
| Impacted wisdom tooth | 38 | 34 | 4 | 0 | 100% |
Data according to table 1 are it can be seen that the present invention is used for the medicine of narcotic analgesic, and analgesic hemostatic is effective, instant effect, through postoperative 1 week reviewing statistics, postoperative without infecting and comparatively fast recovering sensation, have no adverse reaction.
Above example only in order to technical scheme to be described, is not intended to limit；Although the present invention being described in detail with reference to previous embodiment, it will be understood by those within the art that: the technical scheme described in foregoing embodiments still can be modified by it, or wherein portion of techniques feature is carried out equivalent replacement；And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (5)
1. a narcotic analgesic medicine, it is characterized in that, be made up of the raw material of following weight portion: 20～30 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 8～15 parts of Pericarpium Zanthoxyli, Rhizoma Cyperi 3～10 parts, Stigma Croci 5～10 parts, cloud sedge 1～5 part, Herba Asari 2～6 parts, 1～7 part of Herba Ephedrae, Herba speranskiae tuberculatae 2～10 parts, Rhizoma Acori Graminei 6～10 parts, Herba Menthae 6～12 parts, 5～10 parts of Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae 4～10 parts, the Radix Angelicae Dahuricae 3～8 parts, Fructus Piperis Longi 4～8 parts, Ramulus et Folium Debregeasiae Edulis 6～10 parts, Radix Notoginseng 5～10 parts, Flos Matricariae chamomillae 6～12 parts, Herba Schizonepetae 4～8 parts, Pericarpium Citri Reticulatae 3～7 parts, 4～10 parts of Radix Rubiae.
2. narcotic analgesic medicine as claimed in claim 1, it is characterized in that, be made up of the raw material of following weight portion: 22～28 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 10～13 parts of Pericarpium Zanthoxyli, Rhizoma Cyperi 5～9 parts, Stigma Croci 6～8 parts, cloud sedge 2～4 parts, Herba Asari 3～6 parts, 2～6 parts of Herba Ephedrae, Herba speranskiae tuberculatae 3～9 parts, Rhizoma Acori Graminei 7～9 parts, Herba Menthae 5～10 parts, 6～8 parts of Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae 5～8 parts, the Radix Angelicae Dahuricae 4～7 parts, Fructus Piperis Longi 5～7 parts, Ramulus et Folium Debregeasiae Edulis 7～9 parts, Radix Notoginseng 6～8 parts, Flos Matricariae chamomillae 7～11 parts, Herba Schizonepetae 5～7 parts, Pericarpium Citri Reticulatae 4～6 parts, 5～9 parts of Radix Rubiae.
3. narcotic analgesic medicine as claimed in claim 2, it is characterized in that, be made up of the raw material of following weight portion: 23 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 10 parts of Pericarpium Zanthoxyli, Rhizoma Cyperi 5 parts, Stigma Croci 6 parts, cloud sedge 3 parts, Herba Asari 3 parts, 3 parts of Herba Ephedrae, Herba speranskiae tuberculatae 4 parts, Rhizoma Acori Graminei 7 parts, Herba Menthae 7 parts, 6 parts of Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae 5 parts, the Radix Angelicae Dahuricae 4 parts, Fructus Piperis Longi 5 parts, Ramulus et Folium Debregeasiae Edulis 7 parts, Radix Notoginseng 6 parts, Flos Matricariae chamomillae 6 parts, Herba Schizonepetae 5 parts, Pericarpium Citri Reticulatae 4 parts, 5 parts of Radix Rubiae.
4. narcotic analgesic medicine as claimed in claim 2, it is characterized in that, be made up of the raw material of following weight portion: 25 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 12 parts of Pericarpium Zanthoxyli, Rhizoma Cyperi 6 parts, Stigma Croci 7 parts, cloud sedge 4 parts, Herba Asari 4 parts, 4 parts of Herba Ephedrae, Herba speranskiae tuberculatae 5 parts, Rhizoma Acori Graminei 8 parts, Herba Menthae 9 parts, 8 parts of Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae 6 parts, the Radix Angelicae Dahuricae 5 parts, Fructus Piperis Longi 6 parts, Ramulus et Folium Debregeasiae Edulis 8 parts, Radix Notoginseng 6 parts, Flos Matricariae chamomillae 8 parts, Herba Schizonepetae 5 parts, Pericarpium Citri Reticulatae 4 parts, 8 parts of Radix Rubiae.
5. the manufacture method of the narcotic analgesic medicine as described in any one of Claims 1 to 4, it is characterised in that comprise the following steps that:
(1) first weigh a certain proportion of Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Zanthoxyli, Rhizoma Cyperi, Stigma Croci, cloud sedge, Herba Asari are then placed in pulverizer, carry out pulverization process, grind the fine powder crossing 180 orders afterwards into powder, standby；
(2) a certain proportion of Herba Ephedrae, Herba speranskiae tuberculatae, Rhizoma Acori Graminei, Herba Menthae, Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae, the Radix Angelicae Dahuricae, Fructus Piperis Longi, Ramulus et Folium Debregeasiae Edulis are weighed, then clean, the alcohol solution dipping of the 80% of immersion 5～6 times amount 1～2 hour, heating extraction 3 hours, reclaim ethanol, filtering to get filtrate, finally concentration is thick paste, standby；
(3) weigh a certain proportion of Radix Notoginseng, Flos Matricariae chamomillae, Herba Schizonepetae, Pericarpium Citri Reticulatae, Radix Rubiae, put into container, add the distilled water of 8～10 times amount, after soaking 5～6 hours, decoct 3～4 hours, filter, obtain filtering residue and extracting solution；In filtering residue, again add 6～8 times amount distilled water, decoct 2～3 hours, extract；Finally, add 4～6 times amount distilled water, heated and boiled 1～2 hour, extract；Merge three extracting solution, filter to get filtrate, concentrate thick paste, standby；
(4) thick for the fine powder obtained by above-mentioned steps (1)～(3), cream and juice are mixed, make tablet, obtain the medicine of described treatment narcotic analgesic.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103990103A (en) * | 2014-06-18 | 2014-08-20 | 王永 | Medicine for local anaesthesia and preparation method of medicine |
| CN104758690A (en) * | 2015-04-08 | 2015-07-08 | 宋修响 | Traditional Chinese medicinal preparation for treating pre-operative anesthesia and preparation method of traditional Chinese medicinal preparation |
| CN104784396A (en) * | 2015-05-05 | 2015-07-22 | 青岛大学附属医院 | Narcotic painkiller |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103990103A (en) * | 2014-06-18 | 2014-08-20 | 王永 | Medicine for local anaesthesia and preparation method of medicine |
| CN104758690A (en) * | 2015-04-08 | 2015-07-08 | 宋修响 | Traditional Chinese medicinal preparation for treating pre-operative anesthesia and preparation method of traditional Chinese medicinal preparation |
| CN104784396A (en) * | 2015-05-05 | 2015-07-22 | 青岛大学附属医院 | Narcotic painkiller |
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