CN105746905A - Feed additive and preparation method thereof - Google Patents
Feed additive and preparation method thereof Download PDFInfo
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- CN105746905A CN105746905A CN201610116415.4A CN201610116415A CN105746905A CN 105746905 A CN105746905 A CN 105746905A CN 201610116415 A CN201610116415 A CN 201610116415A CN 105746905 A CN105746905 A CN 105746905A
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Abstract
The invention provides a feed additive and a preparation method thereof. The feed additive comprises butyric acid monohydric alcohol ester, wherein the butyric acid monohydric alcohol is prepared from butyric acid and monohydric alcohol. Compared with tributyrin and enveloped sodium butyrate in the prior art, the butyric acid monohydric alcohol ester in the feed additive is good in palatability, free of smell and low in cost, a butyric acid biological function can be relatively well achieved, the production performance of bred animals can be improved, and the addition concentration of the feed additive in a feed is 10-10000mg/kg.
Description
Technical field
The present invention relates to field of feed, more specifically, relate to a kind of feed additive butanoic acid unitary alcohol ester that butanoic acid biological function is provided and preparation method thereof.
Background technology
Butanoic acid, sodium butyrate, the additives such as peplos sodium butyrate and glycerin tributyrate have been widely used in cultivated animals feedstuff, it has the intestinal growth promoting cultivated animals and repairs the effect of intestinal mucosa damaged cell, and to cultivated animals provide intestinal cell nutrition, safeguard intestinal health, reduce animal have loose bowels and in disease generation, have good effect.
But, butanoic acid and sodium butyrate have strong foreign odor taste, and physical and mental health and environmental conservation to human body all can have a negative impact, and therefore butanoic acid and sodium butyrate should not be directly used in feedstuff.For drawbacks described above, research worker adopts the enteric capsulating material such as polyacrylic resin and stearic acid monoglycerides sodium butyrate, calcium butyrate to be coated, when butanoic acid can be allowed to cross stomach, it is to avoid be absorbed in the stomach the energy feed source becoming common, the foul smell of butanoic acid can be covered again；But, above-mentioned capsulating material is too high relative to cost feedstuff with low cost, thus through the popularization of last decade, remains without and is widely accepted and uses in a large number in feedstuff.
At present, glycerin tributyrate is nearly additive extensively recommended in field of fodder for 1 year, but glycerin tributyrate taste is very bitter and puckery, and also without fragrance, addition is slightly many, it is possible to can affect the palatability of feedstuff, is also unfavorable in feedstuff and applies.
Therefore it provides a kind of abnormal smells from the patient is good, cost is low and has higher cultivated animals produces the feed additive of performance, become the technical problem that those skilled in the art are urgently to be resolved hurrily.
Summary of the invention
In view of this, it is an object of the invention to provide a kind of feed additive and preparation method thereof, feed additive good palatability provided by the invention, be destitute of smell, cost low, can better realize butanoic acid biological function, improve cultivated animals and produce performance.
The invention provides a kind of feed additive, described feed additive can provide butanoic acid biological function for feedstuff；
Described feed additive includes: butanoic acid unitary alcohol ester；
Described butanoic acid unitary alcohol ester provides energy nutrient material butanoic acid for intestinal cell, repairs intestinal mucosa, intestinal villus film damaged cell, safeguards that animal intestinal is healthy, reduces the generation of cultivated animals disease, thus improving cultivated animals to produce performance.
Preferably, described butanoic acid unitary alcohol ester interpolation concentration in feedstuff is 10mg/kg～100000mg/kg.
Preferably, described feedstuff includes the feedstuff of pig, horse, cattle, sheep, Canis familiaris L., cat, ermine, deer, tiger, Vulpes, rabbit, chicken, duck, goose, Carnis Coturnicis japonicae, Columba livia, turkey, fish, shrimp, Monopteri albi, Misgurni anguillicaudati, the frog, shellfish, Eriocheir sinensis, Trionyx sinensis Wiegmann, Testudinis, Serpentis；
Described feedstuff also includes mixed feed, mixed fodder, concentrated feed, mineral trace element premixed feed, vitamin premixed feed, compound premixed feed, expanded pellet diet, substitute breast milk or customized feed.
Preferably, described feed additive also includes:
Diluent；
The mass ratio of described diluent and butanoic acid unitary alcohol ester is (1～100000): 100.
Preferably, described diluent includes one or more in Vermiculitum, white carbon, Semen Maydis powder, maize cob meal, oils and fats, propanoic acid, double; two propanoic acid ammonium and glycerol butyrate.
The preparation method that present invention also offers a kind of feed additive, comprises the following steps:
A) butanoic acid and monohydric alcohol are reacted under catalyst action in water entrainer, obtain butanoic acid unitary alcohol ester；
Described monohydric alcohol includes methanol, ethanol, propanol, isopropanol, propenyl, butanol, isobutanol, butenol, amylalcohol, isoamyl alcohol, pentenol, hexanol, Hexalin, hexenol, dissident's alcohol, enanthol, heptenol, capryl alcohol, nonyl alcohol, decanol, undecyl alcohol, lauryl alcohol, tridecanol, myristyl alcohol, pentadecanol, hexadecanol, Heptadecyl alcohol, octadecanol, nonadecanol, eicosanol, tadenan, tetracosanol, hexacosanol, octacosanol, one or more in benzylalcohol；
B) the butanoic acid unitary alcohol ester that diluent and step a) obtain is mixed, obtain feed additive.
Preferably, catalyst described in step a) includes one or more in sulfamic acid, sulphuric acid, p-methyl benzenesulfonic acid, trifluoromethanesulfonic acid.
Preferably, water entrainer described in step a) includes one or more in dimethyl carbonate, ethyl propionate and methyl butyrate.
Preferably, described in step a), the temperature of reaction is 60 DEG C～180 DEG C, and the time is 2h～9h.
Preferably, described step a) also includes:
The product obtained after described reaction is carried out post processing, obtains butanoic acid unitary alcohol ester；
The process of described post processing specifically includes following steps:
The product obtained after described reaction is sequentially passed through cooling, filtration, washing, dry and rectification, obtains butanoic acid unitary alcohol ester.
The invention provides a kind of feed additive and preparation method thereof, feed additive described in described feed additive can provide butanoic acid biological function for feedstuff；Described feed additive includes: butanoic acid unitary alcohol ester；Described butanoic acid unitary alcohol ester provides energy nutrient material butanoic acid for intestinal cell, repairs intestinal mucosa, intestinal villus film damaged cell, safeguards that animal intestinal is healthy, reduces the generation of cultivated animals disease, thus improving cultivated animals to produce performance.Compared with prior art, feed additive butanoic acid unitary alcohol ester good palatability provided by the invention, be destitute of smell, cost low, can better realize butanoic acid biological function, and avoid butanoic acid to be absorbed in the stomach when crossing stomach, but obtain butanoic acid through viokase effect degraded in small intestinal, thus realizing butanoic acid biological function, there is provided nutrition for intestinal cell, repair intestinal mucosa damaged cell, safeguard that animal intestinal is healthy, reduce the generation of cultivated animals disease, thus improving cultivated animals to produce performance.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, technical scheme is clearly and completely described, it is clear that described embodiment is only a part of embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, any amendment that those of ordinary skill in the art make and retouching, broadly fall into the scope of protection of the invention.
The invention provides a kind of feed additive, described feed additive can provide butanoic acid biological function for feedstuff；
Described feed additive includes: butanoic acid unitary alcohol ester；
Described butanoic acid unitary alcohol ester provides energy nutrient material butanoic acid for intestinal cell, repairs intestinal mucosa, intestinal villus film damaged cell, safeguards that animal intestinal is healthy, reduces the generation of cultivated animals disease, thus improving cultivated animals to produce performance.
At present, periodical, magazine, paper etc. are showed no butanoic acid unitary alcohol ester application report in feedstuff, only have in the patent of several feedstuff flavouring agents and employ methyl butyrate, ethyl n-butyrate., benzyl butyrate, are now listed below:
(1) Zhejiang A & F University, Wang Haifeng, CN103070298A: ethyl n-butyrate. 1～5 part or 11.7 parts, benzyl butyrate 8.4～14.7 parts in weight portion 1000 parts, the dosage of the pig bionical feedstuff flavouring agent of breast is 350～550 g ton.Maximum in butanoic acid unitary alcohol ester feedstuff in this patent make consumption: ethyl n-butyrate. 6.435 g ton；Benzyl butyrate 8.085 g ton.
(2) Shanghai Meinong Biotechnology Co., Ltd., CN102987081A: relate to a kind of feedstuff flavouring agent with luring function and preparation method thereof, this feedstuff flavouring agent includes following weight portion formula: ethyl n-butyrate. 2～6, ethyl lactate 2～5, butanoic acid 2～10, nonyl lactone 20～70, γ-octalactone 5～25, δ-decalactone 2～15, δ-dodecalactone 2～10, butter ester 2～15, ethyl vanillin 30～80, carrier 500～900；CN102987084A: a kind of for the feedstuff flavouring agent in premix material, it is characterized in that, this feedstuff flavouring agent includes following components and weight portion content: nonyl lactone 4～20, ethyl vanillin 3～25, pentadecanolide 0.3～2, ethylmaltol 1～8, dihydrocoumarin 1～10, benzyl alcohol 4～20, ethyl lactate 4～20, ethyl n-butyrate. 5～20, carrier 100～800.Experimental condition: 23 age in days ablactational baby pig (DLY), first starting weight about 6.19kg, phagostimulant 108A addition 350g/T.
Maximum in butanoic acid unitary alcohol ester feedstuff in above-mentioned two patents make consumption ethyl n-butyrate. 7 g ton.It is known that, feedstuff flavouring agent in feedstuff maximum addition no more than 1000 g ton, by above-mentioned patent, the butanoic acid unitary alcohol ester maximum addition in feedstuff is less than 10mg/kg, it is only used as flavouring ingredient at most, not as the feed additive providing butanoic acid biological function, with the difference that the present invention has essence.
In the present invention, described butanoic acid unitary alcohol ester is as the derivant of butanoic acid, described feed additive can either be made to have good abnormal smells from the patient, can avoiding being absorbed in the stomach the energy feed source becoming common when crossing stomach again, in small intestinal, obtaining butanoic acid through viokase effect degraded, thus realizing butanoic acid biological function, nutrition is provided for intestinal cell, repair intestinal mucosa damaged cell, safeguard that animal intestinal is healthy, reduce the generation of cultivated animals disease.
In the present invention, described butanoic acid unitary alcohol ester is prepared from by butanoic acid and monohydric alcohol.In the present invention, described monohydric alcohol includes methanol, ethanol, propanol, isopropanol, propenyl, butanol, isobutanol, butenol, amylalcohol, isoamyl alcohol, pentenol, hexanol, Hexalin, hexenol, dissident's alcohol, enanthol, heptenol, capryl alcohol, nonyl alcohol, decanol, undecyl alcohol, lauryl alcohol, tridecanol, myristyl alcohol, pentadecanol, hexadecanol, Heptadecyl alcohol, octadecanol, nonadecanol, eicosanol, tadenan, tetracosanol, hexacosanol, octacosanol, one or more in benzylalcohol, it is preferably methanol, ethanol, propanol, butanol, one or more in lauryl alcohol and octacosanol, it is more preferably methanol, one or more in ethanol and butanol.The source of described monohydric alcohol is not particularly limited by the present invention, adopts the commercial goods of above-mentioned monohydric alcohol well known to those skilled in the art.
In the present invention, described feed additive preferably also includes: diluent.In the present invention, described diluent preferably includes one or more in Vermiculitum, white carbon, Semen Maydis powder, maize cob meal, propanoic acid, double; two propanoic acid ammonium, oils and fats and glycerol butyrate, more preferably white carbon.In the present invention, described diluent can active adsorption butanoic acid unitary alcohol ester, the source of described diluent is not particularly limited by the present invention, adopts the commercial goods of above-mentioned Vermiculitum well known to those skilled in the art, white carbon, Semen Maydis powder, maize cob meal, propanoic acid, double; two propanoic acid ammonium, oils and fats and glycerol butyrate.In the present invention, described diluent is preferably (1～100000) with the mass ratio of butanoic acid unitary alcohol ester: 100, more preferably (30～100): 100.
In the present invention, described feedstuff includes the feedstuff of pig, horse, cattle, sheep, Canis familiaris L., cat, ermine, deer, tiger, Vulpes, rabbit, chicken, duck, goose, Carnis Coturnicis japonicae, Columba livia, turkey, fish, shrimp, Monopteri albi, Misgurni anguillicaudati, the frog, shellfish, Eriocheir sinensis, Trionyx sinensis Wiegmann, Testudinis, Serpentis；
Described feedstuff also includes mixed feed, mixed fodder, concentrated feed, mineral trace element premixed feed, vitamin premixed feed, compound premixed feed, expanded pellet diet, substitute breast milk or customized feed.In the present invention, described feed additive adopts addition manner well known to those skilled in the art to join in feedstuff, it is preferred to use churned mechanically mode is added, it is therefore an objective to make feed additive be dispersed in feedstuff.
In the present invention, described feed additive interpolation concentration in above-mentioned feedstuff is 10mg/kg～100000mg/kg, it is preferred to 50mg/kg～50000mg/kg, more preferably 2000mg/kg～50000mg/kg.
The preparation method that present invention also offers a kind of feed additive, comprises the following steps:
A) butanoic acid and monohydric alcohol are reacted under catalyst action in water entrainer, obtain butanoic acid unitary alcohol ester；
Described monohydric alcohol includes methanol, ethanol, propanol, isopropanol, propenyl, butanol, isobutanol, butenol, amylalcohol, isoamyl alcohol, pentenol, hexanol, Hexalin, hexenol, dissident's alcohol, enanthol, heptenol, capryl alcohol, nonyl alcohol, decanol, undecyl alcohol, lauryl alcohol, tridecanol, myristyl alcohol, pentadecanol, hexadecanol, Heptadecyl alcohol, octadecanol, nonadecanol, eicosanol, tadenan, tetracosanol, hexacosanol, octacosanol, one or more in benzylalcohol；
B) the butanoic acid unitary alcohol ester that diluent and step a) obtain is mixed, obtain feed additive.
In the present invention, butanoic acid and monohydric alcohol are reacted under catalyst action in water entrainer, obtain butanoic acid unitary alcohol ester.In the present invention, described monohydric alcohol includes methanol, ethanol, propanol, isopropanol, propenyl, butanol, isobutanol, butenol, amylalcohol, isoamyl alcohol, pentenol, hexanol, Hexalin, hexenol, dissident's alcohol, enanthol, heptenol, capryl alcohol, nonyl alcohol, decanol, undecyl alcohol, lauryl alcohol, tridecanol, myristyl alcohol, pentadecanol, hexadecanol, Heptadecyl alcohol, octadecanol, nonadecanol, eicosanol, tadenan, tetracosanol, hexacosanol, octacosanol, one or more in benzylalcohol, it is preferably methanol, ethanol, propanol, butanol, one or more in lauryl alcohol and octacosanol, it is more preferably methanol, one or more in ethanol and butanol.The source of described monohydric alcohol is not particularly limited by the present invention, adopts the commercial goods of above-mentioned monohydric alcohol well known to those skilled in the art.
In the present invention, described catalyst preferably includes one or more in sulfamic acid, sulphuric acid, p-methyl benzenesulfonic acid, trifluoromethanesulfonic acid, more preferably sulfamic acid, trifluoromethanesulfonic acid.In the present invention, the effect of described catalyst is to make butanoic acid and monohydric alcohol carry out esterification.The source of described catalyst is not particularly limited by the present invention, adopts above-mentioned sulfamic acid well known to those skilled in the art, sulphuric acid and p-methyl benzenesulfonic acid, trifluoromethanesulfonic acid, commercial goods.
In the present invention, described water entrainer preferably includes one or more in dimethyl carbonate, ethyl propionate and methyl butyrate, more preferably methyl butyrate.In the present invention, water can be taken out of reaction system by described water entrainer in time, has broken the thermodynamical equilibrium of reaction, makes reaction to being conducive to the direction generating ester to carry out；Have solvent action concurrently simultaneously.The source of described water entrainer is not particularly limited by the present invention, adopts the commercial goods of above-mentioned dimethyl carbonate well known to those skilled in the art, ethyl propionate and methyl butyrate.
In the present invention, butanoic acid and monohydric alcohol are reacted under catalyst action in water entrainer, obtain butanoic acid unitary alcohol ester.In the present invention, the mol ratio of described butanoic acid, monohydric alcohol, catalyst and water entrainer is preferably (1.0～1.5): (1.0～1.5): (0.05～0.5): (0.2～0.5).
In the present invention, described reaction preferably employs the mode being heated to reflux and carries out；The temperature of described reaction is preferably 60 DEG C～180 DEG C, more preferably 80 DEG C～125 DEG C；The time of described reaction is preferably 2h～9h, more preferably 8h.
In the present invention, after butanoic acid and monohydric alcohol being reacted under catalyst action in water entrainer, it is preferable that also include:
The product obtained after described reaction is carried out post processing, obtains butanoic acid unitary alcohol ester.In the present invention, the purpose of described post processing is that the butanoic acid unitary alcohol ester in the product obtained after reaction is purified.In the present invention, the process of described post processing preferably specifically includes following steps:
The product obtained after described reaction is sequentially passed through cooling, filtration, washing, dry and distillation, obtains butanoic acid unitary alcohol ester.In the present invention, the purpose of described filtration is filtration catalizer, and it is not specifically limited to this for the present invention.
In the present invention, the cleanout fluid used by described washing process is preferably mass concentration is 10% sodium bicarbonate solution.In the present invention, above-mentioned cleanout fluid is adopted to carry out washing process, it is possible to the product middle acid substance obtained after eliminating reaction and unreacted butanoic acid and monohydric alcohol.
In the present invention, the product after dry dewatering is purified by described still-process further, obtains the butanoic acid unitary alcohol ester that purity is higher.
After obtaining described butanoic acid unitary alcohol ester, diluent and butanoic acid unitary alcohol ester are mixed by the present invention, obtain feed additive.The mode of described mixing is not particularly limited by the present invention, adopts the technical scheme of mechanical agitation well known to those skilled in the art or manual stirring, it is therefore an objective to make diluent and butanoic acid unitary alcohol ester mix homogeneously.In the present invention, the mass ratio of described diluent and butanoic acid unitary alcohol ester is (1～100000): 100, it is preferred to (30～100): 100.
The invention provides a kind of feed additive and preparation method thereof, feed additive described in described feed additive can provide butanoic acid biological function for feedstuff；Described feed additive includes: butanoic acid unitary alcohol ester；Described butanoic acid unitary alcohol ester provides energy nutrient material butanoic acid for intestinal cell, repairs intestinal mucosa, intestinal villus film damaged cell, safeguards that animal intestinal is healthy, reduces the generation of cultivated animals disease, thus improving cultivated animals to produce performance.Compared with prior art, feed additive butanoic acid unitary alcohol ester good palatability provided by the invention, be destitute of smell, cost low, can better realize butanoic acid biological function, and avoid butanoic acid to be absorbed in the stomach when crossing stomach, but obtain butanoic acid through viokase effect degraded in small intestinal, thus realizing butanoic acid biological function, there is provided nutrition for intestinal cell, repair intestinal mucosa damaged cell, safeguard that animal intestinal is healthy, reduce the generation of cultivated animals disease, thus improving cultivated animals to produce performance.
In order to further illustrate the present invention, it is described in detail below by following example.
Embodiment 1
(1) in 2000L enamel reaction still, being sequentially added into 99% butanoic acid 1000kg, methanol 450kg, sulfamic acid 25kg, at 80 DEG C, heating is to backflow, reacts 8h, obtains reactant liquor；By above-mentioned reactant liquor successively cooled, filter sulfamic acid after, wash with the sodium bicarbonate solution that mass concentration is 10% again, eliminating the acidic materials in reactant liquor and unreacted butanoic acid and methanol, stand, upper strata is methyl butyrate, lower floor is water, then dry with anhydrous sodium sulfate and dewater, finally distill, collect 98 DEG C～110 DEG C fractions, obtain the methyl butyrate 1142kg that purity is 99.3%, yield 98.5%.
(2) above-mentioned methyl butyrate is mixed homogeneously with white carbon, obtain the feed additive that methyl butyrate weight/mass percentage composition is 60%.
Embodiment 2
(1) in 2000L enamel reaction still, being sequentially added into 99% butanoic acid 1000kg, ethanol 630kg, sulfamic acid 25kg, at 85 DEG C～98 DEG C, heating is to backflow, reacts 7h, obtains reactant liquor；By above-mentioned reactant liquor successively cooled, filter sulfamic acid after, wash with the sodium bicarbonate solution that mass concentration is 10% again, stand, eliminate the acidic materials in reactant liquor and unreacted butanoic acid and ethanol, then dry with anhydrous sodium sulfate and dewater, finally distill, collect 120 DEG C～125 DEG C fractions, obtain the ethyl n-butyrate. 1300kg that purity is 98.3%, yield 97.6%.
(2) above-mentioned ethyl n-butyrate. is mixed homogeneously with white carbon, obtain the feed additive that ethyl n-butyrate. weight/mass percentage composition is 60%.
Embodiment 3
(1) in 2000L enamel reaction still, being sequentially added into 99% butanoic acid 800kg, propanol 700kg, sulfamic acid 25kg, at 90 DEG C～108 DEG C, heating is to backflow, reacts 9h, obtains reactant liquor；By above-mentioned reactant liquor successively cooled, filter sulfamic acid after, wash with the sodium bicarbonate solution that mass concentration is 10% again, stand, eliminate the acidic materials in reactant liquor and unreacted butanoic acid and propanol, then dry with anhydrous sodium sulfate and dewater, finally distill, collect 142 DEG C～145 DEG C fractions, obtain the propyl butyrate 1160kg that purity is 99.1%, yield 97.2%.
(2) above-mentioned propyl butyrate is mixed homogeneously with Vermiculitum, obtain the feed additive that propyl butyrate weight/mass percentage composition is 60%.
Embodiment 4
(1) in 2000L enamel reaction still, being sequentially added into 99% butanoic acid 800kg, butanol 750kg, sulfamic acid 25kg and dimethyl carbonate 150kg, at 115 DEG C, heating is to backflow, reacts 8h, obtains reactant liquor, isolate water generation reaction 164kg；By above-mentioned reactant liquor successively cooled, filter sulfamic acid after, wash with the sodium bicarbonate solution that mass concentration is 10% again, eliminate the acidic materials in reactant liquor and unreacted butanoic acid, then dry with anhydrous sodium sulfate and dewater, finally distill, collect 166 DEG C～170 DEG C fractions, obtain the butyl butyrate 1269kg that purity is 98.6%, yield 96.8%.
(2) above-mentioned butyl butyrate is mixed homogeneously with white carbon, obtain the feed additive that butyl butyrate weight/mass percentage composition is 60%.
Embodiment 5
(1) in 2000L enamel reaction still, being sequentially added into 99% butanoic acid 400kg, lauryl alcohol 900kg, p-methyl benzenesulfonic acid 10kg and methyl butyrate 200kg, at 120 DEG C, heating is to backflow, reacts 8h, isolates water generation reaction 82kg, obtain reactant liquor；The sodium bicarbonate solution that above-mentioned reactant liquor mass concentration is 10% is washed, eliminate the acidic materials in reactant liquor and unreacted butanoic acid, then dry with anhydrous sodium sulfate and dewater, finally distill, collect 259 DEG C～260 DEG C fractions, obtain the butanoic acid dodecane alcohol ester 1175kg that purity is 96.5%, yield 96.8%.
(2) being mixed homogeneously with white carbon by above-mentioned butanoic acid dodecane alcohol ester, obtaining butanoic acid dodecane alcohol ester weight/mass percentage composition is the feed additive of 60%.
Embodiment 6
(1) in 2000L enamel reaction still, being sequentially added into 99% butanoic acid 200kg, octacosanol 625kg, trifluoromethanesulfonic acid 1.0kg and ethyl propionate 800kg, at 105-108 DEG C, heating is to backflow, reacts 8h, isolate water generation reaction 27.3kg, obtain reactant liquor；Wash with the sodium bicarbonate solution that mass concentration is 10%, eliminate unreacted excessive butanoic acid and catalyst trifluoromethanesulfonic acid in reactant liquor, then dry with anhydrous sodium sulfate and dewater, finally carry out distillating water entrainer ethyl propionate 800kg, obtain the butanoic acid octacosane alcohol ester 765kg that purity is 95.2%, yield 99.6%..
(2) being mixed homogeneously with white carbon by above-mentioned butanoic acid octacosane alcohol ester, obtaining butanoic acid octacosane alcohol ester weight/mass percentage composition is the feed additive of 60%.
Comparative example 1
The peplos sodium butyrate weight/mass percentage composition that Hangzhou factory produces is the feed additive of 30%.
Comparative example 2
The feed additive that Glyceryl tributyrate weight/mass percentage composition is 50% that Wuhan factory produces.
Embodiment 7: pig is produced the impact experiment of performance by DIFFERENT FEED additive
Choosing the 21 age in days ablactational baby pig 168 that body weight is close, be divided into 7 process groups, each process component is 4 repeating groups, each repeating groups 6 pigs, wherein male and female half and half.The pig feed adopting identical suitable 21 age in days growth stages carries out feeding 30 days, and wherein, the 1st process group adds methyl butyrate 580 g ton of the feed additive 60% that embodiment 1 provides；2nd process group adds ethyl n-butyrate. 660 g ton of the feed additive 60% that embodiment 2 provides；3rd process group adds propyl butyrate 740 g ton of the feed additive 60% that embodiment 3 provides；4th process group adds butyl butyrate 820 g ton of the feed additive 60% that embodiment 4 provides；5th process group adds butanoic acid lauryl 1460 g ton of the feed additive 60% that comparative example 5 provides；6th process group adds peplos sodium butyrate 1000 g ton of the feed additive 30% that comparative example 1 provides；7th process group adds Glyceryl tributyrate 600 g ton of the feed additive 50% that comparative example 2 provides；Described feed additive interpolation concentration in above-mentioned feedstuff is 300mg/kg (in butanoic acid), and other feed ingredient is the same, and feeding and management is the same, and its result is as shown in table 1:
Pig is produced the impact experiment of performance by table 1 DIFFERENT FEED additive
As shown in Table 1, the feedstuff of the feed additive provided containing embodiment 2～5 is provided, compare and adopt the feedstuff of the feed additive containing comparative example 1～2 offer to get well, wherein ethyl n-butyrate., butanoic acid lauryl improve 14.7%, 15.0% than Glyceryl tributyrate group daily gain, difference extremely notable (P < 0.01)；Improving 10.18%, 10.40% than peplos sodium butyrate daily gain, significant difference (P < 0.05), it is relatively poor that methyl butyrate is likely due to volatile effect.Illustrate that butanoic acid unitary alcohol ester is better than prior art peplos sodium butyrate, Glyceryl tributyrate.
Embodiment 8: chicken is produced the impact experiment of performance by DIFFERENT FEED additive
Choosing the 1 age in days AA broiler chicken chick 420 that body weight is close, be divided into 7 process groups, each process component is 5 repeating groups, each repeating groups 12 chickens, wherein male and female half and half.The chicken feed adopting identical suitable 1 age in days growth stage carries out feeding 42 days, and wherein, the 1st process group adds methyl butyrate 97 g ton of the feed additive 60% that embodiment 1 provides；2nd process group adds ethyl n-butyrate. 110 g ton of the feed additive 60% that embodiment 2 provides；3rd process group adds propyl butyrate 123 g ton of the feed additive 60% that embodiment 3 provides；4th process group adds butyl butyrate 137 g ton of the feed additive 60% that embodiment 4 provides；5th process group adds butanoic acid lauryl 243 g ton of the feed additive 60% that comparative example 5 provides；6th process group adds peplos sodium butyrate 167 g ton of the feed additive 30% that comparative example 1 provides；7th process group adds Glyceryl tributyrate 100 g ton of the feed additive 50% that comparative example 2 provides；Described feed additive interpolation concentration in above-mentioned feedstuff is 50mg/kg (in butanoic acid), and other feed ingredient is the same, and feeding and management is the same, and it is as shown in table 2 that it raises result.
Table 2 DIFFERENT FEED additive affects experimental data to chicken production performance
As shown in Table 1, the feedstuff of the feed additive provided containing embodiment 2～5 is provided, compare and adopt the feedstuff of the feed additive containing comparative example 1～2 offer to get well, wherein ethyl n-butyrate., butanoic acid lauryl improve 4.62%, 6.15% than Glyceryl tributyrate group daily gain, difference not notable (P > 0.05)；Improving 9.68%, 11.29% than peplos sodium butyrate daily gain, significant difference (P < 0.05), methyl butyrate is likely due to volatile, and effect is relatively poor.Illustrate that butanoic acid unitary alcohol ester is better than prior art peplos sodium butyrate, Glyceryl tributyrate.
As shown in Table 2, adopting the feedstuff of the feed additive containing embodiment 1～4 offer to feed, compare the feedstuff adopting the feed additive provided containing comparative example 1～2, the effect at the production aspect of performance improving chicken becomes apparent from.
Equally we horse, cattle, sheep, Canis familiaris L., cat, ermine, deer, tiger, Vulpes, rabbit, duck, goose, Carnis Coturnicis japonicae, Columba livia, turkey, fish, shrimp, Monopteri albi, Misgurni anguillicaudati, the frog, shellfish, Eriocheir sinensis, Trionyx sinensis Wiegmann, Testudinis, Serpentis feedstuff in application butanoic acid unitary alcohol ester can obtain the effect being satisfied with equally.
The described above of the disclosed embodiments, makes professional and technical personnel in the field be capable of or uses the present invention.The multiple amendment of these embodiments be will be apparent from for those skilled in the art, and generic principles defined herein can without departing from the spirit or scope of the present invention, realize in other embodiments.Therefore, the present invention is not intended to be limited to the embodiments shown herein, and is to fit to the widest scope consistent with principles disclosed herein and features of novelty.
Claims (10)
1. a feed additive, it is characterised in that described feed additive can provide butanoic acid biological function for feedstuff；
Described feed additive includes: butanoic acid unitary alcohol ester；
Described butanoic acid unitary alcohol ester provides energy nutrient material butanoic acid for intestinal cell, repairs intestinal mucosa, intestinal villus film damaged cell, safeguards that animal intestinal is healthy, reduces the generation of cultivated animals disease, thus improving cultivated animals to produce performance.
2. feed additive according to claim 1, it is characterised in that described butanoic acid unitary alcohol ester interpolation concentration in feedstuff is 10mg/kg～100000mg/kg.
3. the feed additive according to any one of claim 1～2, it is characterized in that, described feedstuff includes the feedstuff of pig, horse, cattle, sheep, Canis familiaris L., cat, ermine, deer, tiger, Vulpes, rabbit, chicken, duck, goose, Carnis Coturnicis japonicae, Columba livia, turkey, fish, shrimp, Monopteri albi, Misgurni anguillicaudati, the frog, shellfish, Eriocheir sinensis, Trionyx sinensis Wiegmann, Testudinis, Serpentis；
Described feedstuff also includes mixed feed, mixed fodder, concentrated feed, mineral trace element premixed feed, vitamin premixed feed, compound premixed feed, expanded pellet diet, substitute breast milk or customized feed.
4. feed additive according to claim 1, it is characterised in that described feed additive also includes:
Diluent；
The mass ratio of described diluent and butanoic acid unitary alcohol ester is (1～100000): 100.
5. feed additive according to claim 4, it is characterised in that described diluent includes one or more in Vermiculitum, white carbon, Semen Maydis powder, maize cob meal, propanoic acid, double; two propanoic acid ammonium, oils and fats and glycerol butyrate.
6. the preparation method of a feed additive, it is characterised in that comprise the following steps:
A) butanoic acid and monohydric alcohol are reacted under catalyst action in water entrainer, obtain butanoic acid unitary alcohol ester；
Described monohydric alcohol includes methanol, ethanol, propanol, isopropanol, propenyl, butanol, isobutanol, butenol, amylalcohol, isoamyl alcohol, pentenol, hexanol, Hexalin, hexenol, dissident's alcohol, enanthol, heptenol, capryl alcohol, nonyl alcohol, decanol, undecyl alcohol, lauryl alcohol, tridecanol, myristyl alcohol, pentadecanol, hexadecanol, Heptadecyl alcohol, octadecanol, nonadecanol, eicosanol, tadenan, tetracosanol, hexacosanol, octacosanol, one or more in benzylalcohol；
B) the butanoic acid unitary alcohol ester that diluent and step a) obtain is mixed, obtain feed additive.
7. preparation method according to claim 6, it is characterised in that catalyst described in step a) includes one or more in sulfamic acid, sulphuric acid, p-methyl benzenesulfonic acid, trifluoromethanesulfonic acid.
8. preparation method according to claim 6, it is characterised in that water entrainer described in step a) includes one or more in dimethyl carbonate, ethyl propionate and methyl butyrate.
9. preparation method according to claim 6, it is characterised in that described in step a), the temperature of reaction is 60 DEG C～180 DEG C, and the time is 2h～9h.
10. the preparation method according to any one of claim 6～9, it is characterised in that described step a) also includes:
The product obtained after described reaction is carried out post processing, obtains butanoic acid unitary alcohol ester；
The process of described post processing specifically includes following steps:
The product obtained after described reaction is sequentially passed through cooling, filtration, washing, dry and rectification, obtains butanoic acid unitary alcohol ester.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610116415.4A CN105746905A (en) | 2016-03-01 | 2016-03-01 | Feed additive and preparation method thereof |
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| CN201610116415.4A CN105746905A (en) | 2016-03-01 | 2016-03-01 | Feed additive and preparation method thereof |
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| CN105746905A true CN105746905A (en) | 2016-07-13 |
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| CN106359943A (en) * | 2016-10-18 | 2017-02-01 | 杨继刚 | Feed additive capable of improving producing performance and foraging performance of early-weaned lamb |
| CN108719650A (en) * | 2018-06-12 | 2018-11-02 | 辽宁禾丰牧业股份有限公司 | A kind of general point of nest feed of fox racoon dog ermine and preparation method thereof |
| CN109566863A (en) * | 2019-01-18 | 2019-04-05 | 湖北华扬科技发展有限公司 | Feed addictive and its preparation method and application |
| WO2019200675A1 (en) * | 2018-04-18 | 2019-10-24 | 江南大学 | Method for clathrating tributyrin by means of enzymatic method |
| CN114568594A (en) * | 2022-03-28 | 2022-06-03 | 上海美农生物科技股份有限公司 | Additive for slow-release nitrogen source feed and preparation method thereof |
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| CN103931954A (en) * | 2014-05-09 | 2014-07-23 | 河北交通职业技术学院 | Feed additive for regulating and repairing broiler intestines and preparation method of feed additive |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106359943A (en) * | 2016-10-18 | 2017-02-01 | 杨继刚 | Feed additive capable of improving producing performance and foraging performance of early-weaned lamb |
| WO2019200675A1 (en) * | 2018-04-18 | 2019-10-24 | 江南大学 | Method for clathrating tributyrin by means of enzymatic method |
| US11965196B2 (en) | 2018-04-18 | 2024-04-23 | Jiangnan University | Enzymatic preparation method of inclusion complexes of tributyrin |
| CN108719650A (en) * | 2018-06-12 | 2018-11-02 | 辽宁禾丰牧业股份有限公司 | A kind of general point of nest feed of fox racoon dog ermine and preparation method thereof |
| CN109566863A (en) * | 2019-01-18 | 2019-04-05 | 湖北华扬科技发展有限公司 | Feed addictive and its preparation method and application |
| CN114568594A (en) * | 2022-03-28 | 2022-06-03 | 上海美农生物科技股份有限公司 | Additive for slow-release nitrogen source feed and preparation method thereof |
| CN114568594B (en) * | 2022-03-28 | 2023-12-01 | 苏州美农生物科技有限公司 | Additive for slow-release nitrogen source feed and preparation method thereof |
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Application publication date: 20160713 |