CN104186958B - Application of the myristic acid copper as feed addictive - Google Patents
Application of the myristic acid copper as feed addictive Download PDFInfo
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- CN104186958B CN104186958B CN201410222333.9A CN201410222333A CN104186958B CN 104186958 B CN104186958 B CN 104186958B CN 201410222333 A CN201410222333 A CN 201410222333A CN 104186958 B CN104186958 B CN 104186958B
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
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Abstract
The invention provides application of the myristic acid copper as feed addictive, and the application of feeding growth promoter, especially as the effective substitute for being high dose copper sulphate.Its additive in animal feed is 1~200ppm (being calculated with content of copper ion), other copper compounds for the dosage copper such as its growth-promoting effect of each dosage level is significantly better than.Also, in the range of the nutritional need of copper i.e. in 1~30pm, myristic acid copper remains able to remarkably promote growth of animal.Meanwhile the growth enhancing effect of the copper in the copper sulphate source of the alternative high dose of myristic acid copper of low dosage.The dosage that the application in animal feed of the myristic acid copper of the present invention can reduce nearly 90% copper ion reaches identical production performance, application of the copper in animal husbandry can be substantially reduced, production cost can be reduced, reduce the toxic side effect of high-copper, and environmental pollution is reduced, it is the copper compound for possessing unique growth promotion advantage.
Description
Technical field：
The invention belongs to livestock and poultry cultivation field, and in particular to application of the myristic acid copper as feed addictive, and it is feeding
The application of growth promoter, especially as the effective substitute for being high dose copper sulphate.
Background technology：
One of trace element necessary to copper is animal, it is living to participate in the hematopoiesis of animal, metabolism, growth and breeding, disease-resistant etc.
It is dynamic.Animal finds that high-copper can significantly improve the growth performance of pig to the nutritional requirements of copper in 5-8mg/kg, but from 1945
Since, high-copper is widely used in market pig breeding process.At present 150-200ppm is adopted in the young age piglet stage
High-copper (in terms of copper ion) production performance of animal can be significantly improved.
In addition, high-copper also embodies the effect for promoting growth in broiler chicken, part broiler chicken material also applies high-copper growth promotion.It is but high
The prolonged application of copper has the side effect of four aspects.(1) first it is the toxic side effect of high-copper to animal in itself.High-copper can damage dynamic
The internal organs of thing, 200ppm high-copper can cause liver cell enlargement, cytoplasmic granule denaturation, glomerulus enlargement, renal tubule swelling, capsula glomeruli
Ooze out albumen, cardiac muscle fibre granular degeneration, lymphocyte is reduced under spleen, smooth muscle fibers hyperplasia.Broken by testing using high-copper
The ratio that dermatitis nephrosis synthesis disease occurs for milk piglet is higher than low copper by more than 5%, and prompting high-copper is probably pigskin inflammation nephrotic syndrome
One of inducement, and pig resistance can be caused to decline.(2) high-copper can influence food security.High-copper prolonged application can be in animal groups
Knit and remain exceeded in organ, influence the security of food.(3) high-copper can disturb the absorption of other nutritions.(4) high-copper is also made
Into serious environmental pollution.
Therefore new efficient, safe feeding high-copper substitute products are (low dosage copper needed for Modern Animal Husbandry development
Compound is still effective).
The content of the invention：
It is an object of the invention to provide application of the myristic acid copper as animal feed additive.
The present invention is found through experiments that 20ppm myristic acids copper (being calculated with copper content, similarly hereinafter) can reach 200ppm sulphur
Improvement of the sour copper (being calculated with copper content, similarly hereinafter) to experiment piggy production performance.In middle pig growth phase 15ppm myristic acid
Copper can reach the production performance effect of 150ppm copper sulphate.15ppm myristic acids copper can reach the water sulfuric acid of 150ppm five
Improvement of the copper to experiment meat chicken production performance.As can be seen here, it is of the invention using myristic acid copper as additive can copper from
In the case of sub- low dosage, its growth promotion performance reaches the effect added using cupric sulfate pentahydrate as additive copper ion high dose
Should.
Therefore, the invention provides application of the myristic acid copper as animal feed additive, especially as being high dose
The application of effective substitute of copper sulphate and the animal feed additive as Animal feed-additive.It is in animal feed
Additive is 1~200ppm (being calculated with content of copper ion), the dosage such as its growth-promoting effect of each dosage level is significantly better than
Its copper sulphate of copper.Also, in the range of the copper nutritional need i.e. in 1~30pm, myristic acid copper remains able to remarkably promote dynamic
Thing grows.
Described myristic acid copper is the amount of myristic acid and copper material than 2：1 salt.
Described animal can be various cultivated animals, such as duck, goose, beef cattle, milk cow, sheep, various fish and shrimp, fox, ermine, racoon dog
The stage is raised etc. various artificial feeding animals and each, preferably pig and broiler chicken.
Described myristic acid copper, its additive capacity in animal feed are 1~500ppm, preferred dose is 10~
200ppm。
Described animal feed is preferably perfect compound feed, and concentrated feed and premix according to dosage convert.
Described myristic acid copper, its low additive capacity in pig, broiler fodder are that 15~150ppm (is contained with copper ion
Amount calculates) dosage range in promote the effect of growth to be significantly better than other copper chemical combination of high doses of copper (100-200ppm)
Thing, such as copper sulphate (are calculated) with content of copper ion.
Described myristic acid copper, its additive in animal feed are 1~30pm in the range of the nutritional need of copper
Interior, myristic acid copper remains able to remarkably promote growth of animal, and significant effect waits dosage better than what conventional extra-nutrition needed
The compounds such as copper sulphate.
The dosage that the application in animal feed of the myristic acid copper of the present invention can reduce nearly 90% copper ion reaches identical
Production performance, application of the copper in animal husbandry can be substantially reduced, production cost can be reduced, reduce the toxic side effect of high-copper, and
Environmental pollution is reduced, is the copper compound for possessing unique advantage.
Embodiment：
Following examples are to further explanation of the invention, rather than limitation of the present invention.
Embodiment 1：The synthesis of myristic acid copper
600ml water is added in 1L beakers at room temperature, mechanical agitation is opened and adds 7.6g sodium hydroxides (96%, 0.1818mol),
Make to be completely dissolved, add 40g myristic acids (MW：228.38,0.174mol), finish, Sodium myristate is separated out after about 30min
Salt, the stiff that is creamy white cream solid, continue that cupric sulfate pentahydrate (MW is added dropwise after stirring 1h：249.69 0.091mol) aqueous solution
(22.7g cupric sulfate pentahydrate+100ml water), about 15min is added, and continues to stand more than 1h, filtering after stirring 3h, washing three times, is taken out
It is dry, more than 8h is dried in 80 DEG C of baking ovens, obtains light green myristic acid mantoquita (MW：518.28) powder.
After taking reaction product myristic acid copper 0.10g to be dissolved with 100ml 0.1M HCl, nutmeg in GC methods measure solution
Acid content, while with atom absorption method determine solution in copper content.Copper ion and myristic acid in result product
Molecule mol ratio be 1：2.Myristic acid steel structure formula such as formula one.
Formula one：Myristic acid steel structure formula
Embodiment 2：Application effect of the various dose myristic acid copper (prepared by embodiment 1, similarly hereinafter) in small pig feed
120 first 52 ages in days go out nursery house, the miscellaneous lean meat species piggy of DLY ternary such as table 1 divides 6 groups, every group 20 similar in body weight
Head.After each group adds the copper compound of variety classes or dosage in the piggy perfect compound feed without high-copper, free choice feeding
And drinking-water, count weightening and the price of deed of 28 days each test group test pigs.As a result as shown in table 1, raising as can be seen from Table 1
Myristic acid copper is added in material can (in terms of copper content, similarly hereinafter) propose the weightening of test pig, improve feedstuff-meat ratio, and to production performance
Improvement is proportionate with additive capacity, and wherein 20ppm myristic acids copper can reach 200ppm copper sulphate to test pig productivity
The improvement of energy.
Table 1：Growth-promoting effect result of the test of the various dose myristic acid copper to meat piggy
| Group | Size of animal | Additive and dosage (ppm) | Average daily gain (g) | Average feedstuff-meat ratio |
| 1 | 20 | Cupric sulfate pentahydrate 20 | 466 | 2.181 |
| 2 | 20 | Myristic acid copper 10 | 473 | 2.152 |
| 3 | 20 | Myristic acid copper 20 | 499 | 2.032 |
| 4 | 20 | Myristic acid copper 40 | 505 | 2.008 |
| 5 | 20 | Cupric sulfate pentahydrate 200 | 497 | 2.055 |
| 6 | 20 | Cupric sulfate pentahydrate 20+ myristic acids 143 | 469 | 2.172 |
*：The concentration of additive is in terms of copper ion, similarly hereinafter.
Embodiment 3：Application effect of the myristic acid copper in middle pig feed
The miscellaneous lean meat species pork pig of DLY ternary such as table 2 divides 7 groups, every group 20 similar in 140 first 83 ages in days, body weight.Each group
After adding variety classes or the copper compound of dosage or other additives in the piggy perfect compound feed without high-copper, freely
Feeding and drinking-water, count weightening and the price of deed of 28 days each test group test pigs.As a result as shown in table 3, can from table 3
Go out, during experiment improvement of the 15ppm myristic acid copper to test pig production performance be substantially better than isodose copper sulphate, the moon
Cinnamic acid copper, capric acid copper or copper palmitate, and the test effect of 150ppm copper sulphate can be reached.In addition, 150ppm nutmeg
The production performance of sour copper (in terms of copper content, similarly hereinafter) test group is significantly better than 150ppm copper sulfate test groups.
The myristic acid copper of table 2 is grouped in the experiment of middle pig feed application effect
| Group | Size of animal | Additive | Dosage (ppm) * |
| 1 | 20 | Cupric sulfate pentahydrate | 15 |
| 2 | 20 | Myristic acid copper | 15 |
| 3 | 20 | Laurate copper | 15 |
| 4 | 20 | Capric acid copper | 15 |
| 5 | 20 | Copper palmitate | 15 |
| 6 | 20 | Cupric sulfate pentahydrate | 150 |
| 7 | 20 | Myristic acid copper | 150 |
*：The concentration of additive is the similarly hereinafter in terms of copper ion
The result of the test of the myristic acid copper application effect in middle pig feed of table 3
| Group | Size of animal | Additive and dosage | Average daily gain (g) | Feedstuff-meat ratio |
| 1 | 20 | Cupric sulfate pentahydrate 15 | 568 | 2.402 |
| 2 | 20 | Myristic acid copper 15 | 604 | 2.288 |
| 3 | 20 | Laurate copper 15 | 588 | 2.345 |
| 4 | 20 | Capric acid copper 15 | 574 | 2.351 |
| 5 | 20 | Copper palmitate 15 | 581 | 2.348 |
| 6 | 20 | Cupric sulfate pentahydrate 150 | 603 | 2.291 |
| 7 | 20 | Myristic acid copper 150 | 619 | 2.196 |
Embodiment 4：Application effect of the myristic acid copper in broiler chicken material
600 fast big yellow-feather broilers (female seedling) on the 1st are grouped by table 4, every group 100.Each group is without the small of high-copper
After the copper compound that variety classes or dosage are added in chicken perfect compound feed, free choice feeding and drinking-water, each experiment in 21 days is counted
The weightening of group test chicken and the price of deed.As a result as shown in table 5, as can be seen from Table 5,15-30ppm myristic acid copper
(in terms of copper, similarly hereinafter) can significantly improve the daily gain of test chicken, improve material meat, and the improvement to production performance has obvious agent
Graded effect.15ppm myristic acids copper is the improvement that can reach 150ppm cupric sulfate pentahydrates to testing meat chicken production performance.
Experiment packet of the various dose myristic acid copper of table 4 to the growth-promoting effect of broiler chicken
| Group | Size of animal | Additive | Concentration (ppm) * |
| 1 | 100 | Cupric sulfate pentahydrate | 15 |
| 2 | 100 | Cupric sulfate pentahydrate | 15 |
| 3 | 100 | Cupric sulfate pentahydrate | 150 |
| 4 | 100 | Cupric sulfate pentahydrate | 150 |
| 5 | 100 | Myristic acid copper | 15 |
| 6 | 100 | Myristic acid copper | 15 |
*：The concentration of additive is in terms of copper ion, similarly hereinafter.
Growth-promoting effect result of the test of the various dose myristic acid copper of table 5 to broiler chicken
| Group | Size of animal | Additive and dosage ppm | Average daily gain (g) | Feedstuff-meat ratio |
| 1 | 100 | Cupric sulfate pentahydrate 15 | 18.6 | 1.848 |
| 2 | 100 | Cupric sulfate pentahydrate 15 | 19.2 | 1.872 |
| 3 | 100 | Cupric sulfate pentahydrate 150 | 22.7 | 1.742 |
| 4 | 100 | Cupric sulfate pentahydrate 150 | 23.7 | 1.737 |
| 5 | 100 | Myristic acid copper 15 | 23.5 | 1.728 |
| 6 | 100 | Myristic acid copper 15 | 23.6 | 1.731 |
Claims (4)
1. application of the myristic acid copper as animal feed additive, the animal be the pig in artificial feeding stage, chicken, duck or
Goose, additive capacity of the myristic acid copper in feed are calculated as 15~150ppm with content of copper ion.
2. application according to claim 1, it is characterised in that described application is myristic acid copper as promoting animal growth
The application of the animal feed additive of agent
3. application according to claim 1, it is characterised in that described application includes myristic acid copper and added as feed
Agent using meet livestock and poultry to the nutritional need of copper and be used as substitute pig feed in high dose copper sulphate application.
4. application according to claim 1, it is characterised in that described myristic acid copper is myristic acid and copper material
Measure ratio 2：1 salt.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410222333.9A CN104186958B (en) | 2014-05-23 | 2014-05-23 | Application of the myristic acid copper as feed addictive |
| PCT/CN2014/080475 WO2015176342A1 (en) | 2014-05-23 | 2014-06-23 | Application of myristic acid copper as animal feed additive |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410222333.9A CN104186958B (en) | 2014-05-23 | 2014-05-23 | Application of the myristic acid copper as feed addictive |
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| Publication Number | Publication Date |
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| CN104186958A CN104186958A (en) | 2014-12-10 |
| CN104186958B true CN104186958B (en) | 2017-11-21 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105724781A (en) * | 2016-02-23 | 2016-07-06 | 广州英赛特生物技术有限公司 | Feed composition and application thereof to preparation of animal feed additive |
| CN105746908B (en) * | 2016-02-23 | 2018-08-28 | 广州英赛特生物技术有限公司 | Application of the myristic acid derivative in preparing animal growth promoting agent |
| CN105724779A (en) * | 2016-02-23 | 2016-07-06 | 广州英赛特生物技术有限公司 | Compound feeding composition and application of compound feeding composition in preparation of animal feed additive |
| CN105815571A (en) * | 2016-03-25 | 2016-08-03 | 广州英赛特生物技术有限公司 | Feeding composition and application thereof to animal feed additive preparation |
| CN115812858A (en) * | 2022-03-15 | 2023-03-21 | 中国农业大学 | Additive and application thereof in improving egg poultry production performance |
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| CN103547168A (en) * | 2011-05-23 | 2014-01-29 | 格拉斯普工商业有限公司 | Use of encapsulated nitrates and sulfates to reduce methane emission derived from ruminal fermentation |
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| CN1826945A (en) * | 2006-04-07 | 2006-09-06 | 浙江大学 | Antibacterial and health-caring feedstuff addictive and preparation method thereof |
| CN102389048A (en) * | 2011-11-08 | 2012-03-28 | 成都市龙泉驿区十陵禽业合作社 | Sheep feed additive inhibiting escherichia coli O157:H7 |
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- 2014-05-23 CN CN201410222333.9A patent/CN104186958B/en active Active
- 2014-06-23 WO PCT/CN2014/080475 patent/WO2015176342A1/en active Application Filing
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| US3198635A (en) * | 1964-04-17 | 1965-08-03 | Feed Service Corp | Nutrient compositions and process for preparing same |
| CN103547168A (en) * | 2011-05-23 | 2014-01-29 | 格拉斯普工商业有限公司 | Use of encapsulated nitrates and sulfates to reduce methane emission derived from ruminal fermentation |
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| WO2015176342A1 (en) | 2015-11-26 |
| CN104186958A (en) | 2014-12-10 |
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