CN101530167A - Additive of organic copper feed and preparation method and use thereof - Google Patents
Additive of organic copper feed and preparation method and use thereof Download PDFInfo
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- CN101530167A CN101530167A CN200910097724A CN200910097724A CN101530167A CN 101530167 A CN101530167 A CN 101530167A CN 200910097724 A CN200910097724 A CN 200910097724A CN 200910097724 A CN200910097724 A CN 200910097724A CN 101530167 A CN101530167 A CN 101530167A
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Abstract
The invention discloses an additive of organic copper feed and preparation method and use thereof. The method comprises the steps of: stirring under 10 to 60 degrees centigrade, adding chitosan with deacetylation being 70 to 100% into diluted acid with volume percent density being 0.5 to 2% to be 0.5 to 10% chitosan acid solution; then adding inorganic copper solution into the chitosan acid solution; wherein the content of the inorganic copper is 1/5 to 30 times of the content of the chitosan; reacting for 0.5 to 15 hours, separating, washing the obtained solid substances for many times until checking out the ions free of copper, drying, crashing to obtain the additive of organic copper feed. The invention provides a simple method of preparing the additive of organic copper feed, which has stable quality and is widely popularized and applied. The additive can be used as the additive for copper for livestock, birds, aquatic animals and experimental animals. The additive has high biological availability and can save sources and protect the environment and can be sued as an immune dose for improving the resistance against diseases of the animals.
Description
Technical field
The present invention relates to a kind of additive of organic copper feed and its production and use.
Background technology
Copper is the humans and animals trace elements necessary, and concerning animal body, copper is the important component of plurality of enzymes, is again hematopoiesis and prevents the alimentary anemia trace elements necessary.Copper can catalysis ferroheme and erythrocytic formation, can safeguard eucaryotic cell structure and functional integrity again, positive facilitation all be arranged to the hematopoiesis immunologic function of animal body, nerve cell, bone, connective tissue with by grow defensive ability/resistance ability and the breeding performonce fo animals of hair.Therefore, trace copper is guaranteeing to play crucial effect aspect animal body healthy growth and the High-efficient Production.
In the animal production practices, the method for using excess to add inorganic salts (copper sulphate) is usually strengthened the nutrition supply to body copper, and especially in pig industry, (200～300mg/kg) are widely used as growth accelerator high doses of copper.But use high doses of copper to have following problem usually: (1) is not because adults generally is higher than 5%～10% to the absorptivity of copper, young animal is 15%～30%, therefore most copper excretes by ight soil, has also polluted environment when causing the wasting of resources; (2) long-term or excess is used high-copper, inevitable at animal body tissue accumulation considerable part heavy metal element copper, not only cause animal body slow poisoning, tissue residue to increase, reduce edibility, the security of livestock products, the more important thing is that the residual and a large amount of drainage meetings of animal tissue bring very important influence and harm to the mankind and whole ecological chain health; (3) use the fertilising of the high ight soil of copper content for a long time, will cause it in soil, to accumulate pollution, thereby crops are produced toxic action.Simultaneously,, can reduce water body self-purification ability, make water quality deterioration, aquatic organism death in case contain the ight soil polluted source of high concentration copper.Copper is very big to aquatile toxicity, when concentration is 0.5mg/kg in water, can make 35%～100% primary fresh plant death; (4) copper is too much in the feed, will have a negative impact to vitamins stability, causes the shortage of vitamin.High-copper can make the level of the alpha-tocopherol in the feed reduce to almost nil within 22d.Excess copper disturbs has the sulfur-containing compound of free sulfhydryl group (SH) such as the utilization rate of cysteine.High-copper also increases the requirement of animal to sulfur-containing amino acid (methionine, cystine).Have antagonism between copper, zinc, the iron three, the daily ration high-copper makes the utilization rate of zinc, iron reduce, and brings out scarce zinc, iron, shows as diarrhoea and skin disease and increases.(5) high doses of copper utilizes a large amount of free radicals of generation in the process in little intestinal absorption and tissue, and pair cell causes oxidative damage, and the integrality of heavy damage intestinal cell film causes growth of animal to be obstructed, and efficiency of feed utilization reduces, and meat matter descends.Therefore, how to improve micro-bioavailability is one of key issue anxious to be solved always.
Shitosan is chitin (β-1; 4 poly--2-acetylaminohydroxyphenylarsonic acid D-glucose) product behind the part deacetylation is natural high-molecular biologic polymer, and is nontoxic, harmless to the humans and animals body; also be a kind of natural alkaline polysaccharide few in number, its stock number is only second to cellulose.Shitosan has special physiologically active, nontoxic, biodegradable, good biocompatibility can be used as multiple functional materials such as heavy metal chelant, adsorbent, medicine sustained and controlled release agent and are widely used in fields such as chemical industry, environmental protection, food, medicine, cosmetics, agricultural.
Summary of the invention
The objective of the invention is to overcome the defective of above-mentioned existence, a kind of additive of organic copper feed and its production and use is provided.
Additive of organic copper feed is the chitosan copper complex compound, and wherein the weight content of copper is 12～40%.
The additive of organic copper feed preparation method is under 10～60 ℃ of stirrings, and the adding deacetylation is 70～100% shitosan in concentration of volume percent 0.5～2% diluted acid, makes it into 0.5～10% shitosan acid solution; In the shitosan acid solution, add inorganic copper solution then, wherein inorganic copper mass is 1/5～30 times of chitosan mass, reaction 0.5～15h, centrifugal or isolated by filtration, the solid matter that obtains through the distilled water washing repeatedly detects until no copper ion, oven dry, pulverize, promptly get additive of organic copper feed.
Among the present invention, said diluted acid is acetic acid,diluted or watery hydrochloric acid; Inorganic copper solution is copper-bath, copper nitrate solution or copper chloride solution.
Additive of organic copper feed is as the benefit copper feed additive of livestock and poultry, aquatic animal and animal used as test.
The invention provides that the preparation method is simple, constant product quality, a kind of additive of organic copper feed preparation method easy to utilize.In the preparation process, do not use any organic solvent and the surfactant harmful to animal, can directly make an addition in the feed as a kind of organic copper source, this copper source infiltration rate is fast, absorptivity improves greatly, the addition in feed is low; Except that satisfying the nutritional need of animal to trace copper, also can provide the nutrition of polysaccharide simultaneously for animal, improve disease resistance of animals thereby can be used as a kind of immunostimulant; Can avoid the destruction of inorganic copper, prolong shelf life of products nutriments such as vitamins in the feed; Can significantly improve the utilization rate of feed.Because the bioavailability height of this organic copper is so the discharge rate of copper is little in the animal wastes.Therefore, both can economize on resources, can protect environment again, alleviate the adverse effect of breeding production environment.
Additive of organic copper feed of the present invention is applicable to poultry, fowl, aquatic animal and animal used as test, makes an addition to by a certain percentage in premix, the perfect compound feed according to the needs of different animals to get final product.
The specific embodiment
The specific embodiment of the present invention can be selected arbitrarily to replace in described each number range of foregoing invention content, and constitutes different embodiments, is not limited to following embodiment.
Embodiment 1:
Under 10 ℃ of stirrings, the adding deacetylation is 70% shitosan in concentration of volume percent 0.5% diluted acid, makes it into 0.5% shitosan acid solution; Add copper-bath then in the shitosan acid solution, wherein the copper sulphate quality is 1/5 of a chitosan mass, reaction 0.5h, filter, the solid matter that obtains through the distilled water washing repeatedly detects until no copper ion, oven dry is pulverized, and promptly gets additive of organic copper feed.
Embodiment 2:
Under 60 ℃ of stirrings, the adding deacetylation is 100% shitosan in concentration of volume percent 2% diluted acid, makes it into 10% shitosan acid solution; Add copper nitrate solution then in the shitosan acid solution, wherein the copper sulphate quality is 30 times of chitosan mass, reaction 15h, 3000rpm is centrifugal, and the sediment that obtains through the distilled water washing repeatedly detects until no copper ion, oven dry is pulverized, and promptly gets additive of organic copper feed.
Embodiment 3:
Under 10 ℃ of stirrings, in 1% hydrochloric acid, add the shitosan of deacetylation 80%, be mixed with 0.5% shitosan acid solution, in the shitosan acid solution, add copper-bath again, wherein the copper sulphate quality is 1/4 of a chitosan mass, reaction 12h, 3000rpm is centrifugal, and sediment is through the distilled water washing repeatedly, detect until no copper ion, oven dry is pulverized, and promptly gets additive of organic copper feed.
Embodiment 4:
Under 20 ℃ of stirrings, in 1% acetate, add the shitosan of deacetylation 90%, be mixed with 1% shitosan acid solution, in the shitosan acid solution, add copper-bath again, wherein the copper sulphate quality is 5 times of chitosan mass, reaction 15h filters, and solid content through the distilled water washing repeatedly, detect until no copper ion, oven dry is pulverized, and promptly gets additive of organic copper feed.
Embodiment 5:
Under 60 ℃ of stirrings, in 2% acetate, add the shitosan of deacetylation 98%, be mixed with 0.5% shitosan acid solution, in the shitosan acid solution, add copper chloride solution again, wherein the copper chloride quality is 12 times of chitosan mass,, reaction 15h, filter, solid content through the distilled water washing repeatedly detects until no copper ion, oven dry, pulverize, promptly get additive of organic copper feed.
Embodiment 6:
The additive of organic copper feed of using the present invention's preparation makes an addition in the pig starter feed as the copper source.With the weanling pig is subjects, and 180 of the DLY three way cross piglets of selection average weight 7.5kg according to science feeding experiment principle, are divided into 6 processed group at random with test pig, and each handles 3 repetitions, and each repeats 10 pigs.In 6 processed group, wherein 4 groups are added organic copper additives that the above-mentioned example of various dose (50,100,150,200mg/kg copper) provides, and two other group is respectively control group (basal diet group) and interpolation high dose copper sulphate group (200mg/kg copper).All test pig corn-dregs of beans type basal diet of feeding, basal diet is prepared with reference to U.S. NRC (1998) piglet nutritional need.Before the test pig house is carried out disinfection, test pig adopts group feeding, and the duration of test free choice feeding is freely drunk water, and other feeding and management is carried out according to conventional feeding and management rules, and experimental period is 30 days.Result of the test shows that the daily gain of the organic copper group of various dose has improved 15.1～18.3% than control group respectively, wherein 100 and the organic copper group of 150mg/kg daily gain than copper sulphate component you can well imagine high by 4.8%, 5.7%; The diarrhea rate of organic copper group pig obviously reduces than copper sulphate group; Copper content is 21.5～38.7 times of each organic copper group in the copper sulphate group pig manure sample; The organic copper group of various dose serum IgG level has improved 4.2%, 5.4% and 5.6% than control group respectively, serum IgA and the horizontal no significant difference of IgM between each group.
Embodiment 7:
The additive of organic copper feed of using the present invention's preparation makes an addition in the grow-finish pig feed as the copper source.240 of DLY three way cross growth pigs about selection body weight 60kg according to science feeding experiment principle, are divided into 5 processed group at random with test pig, and each handles 3 repetitions, and each repeats 16 pigs.In 5 processed group, wherein 3 groups are added organic copper additives that the above-mentioned example of various dose (50,100,150mg/kg copper) provides, and two other group is respectively control group (basal diet group) and interpolation higher dosage copper sulphate group (150mg/kg copper).All test pig corn-dregs of beans type basal diet of feeding, basal diet is with reference to the preparation of U.S. NRC (1998) growth pig nutritional need.Before the test pig house is carried out disinfection, test pig adopts group feeding, and the duration of test free choice feeding freely is drunk water, and other feeding and management is carried out according to conventional feeding and management rules, and the 100kg end that weighs of test pig average body is tested.Result of the test shows that the daily gain of the organic copper group of various dose has improved 14.7～17.5% than control group respectively, wherein 100 and the organic copper group of 150mg/kg daily gain than copper sulphate component you can well imagine high by 4.6%, 5.5%; Copper content is 27.5～36.8 times of each organic copper group in the copper sulphate group pig manure sample; The copper residual quantity is than reducing by 4.3% with dosage copper sulphate group in each histoorgan of the organic copper group of 150mg/kg pig.
Claims (5)
1. an additive of organic copper feed is characterized in that described additive is the complex compound of shitosan and copper, and wherein the weight content of copper is 12～40%.
2. the preparation method of an additive of organic copper feed is characterized in that under 10～60 ℃ of stirrings, and the adding deacetylation is 70～100% shitosan in concentration of volume percent 0.5～2% diluted acid, makes it into 0.5～10% shitosan acid solution; Add inorganic copper solution then in the shitosan acid solution, wherein inorganic copper mass is 1/5～30 times of chitosan mass, reaction 0.5～15h, centrifugal or isolated by filtration, the solid matter that obtains washs through distilled water, detects until no copper ion, oven dry is pulverized, and promptly gets additive of organic copper feed.
3. a kind of additive of organic copper feed preparation method according to claim 1 is characterized in that described diluted acid is acetic acid,diluted or watery hydrochloric acid.
4. a kind of additive of organic copper feed preparation method according to claim 1 is characterized in that described inorganic copper solution is copper-bath, copper nitrate solution or copper chloride solution.
5. the purposes of additive of organic copper feed according to claim 1 is characterized in that, it is as the benefit copper feed additive of livestock and poultry, aquatic animal and animal used as test.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910097724A CN101530167A (en) | 2009-04-16 | 2009-04-16 | Additive of organic copper feed and preparation method and use thereof |
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| CN200910097724A CN101530167A (en) | 2009-04-16 | 2009-04-16 | Additive of organic copper feed and preparation method and use thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102835610A (en) * | 2012-09-27 | 2012-12-26 | 淮阴工学院 | Feed additive for broiler chickens and preparation method thereof |
| CN103005212A (en) * | 2012-12-26 | 2013-04-03 | 浙江大学 | Feed additive for improving intestinal functions of piglets and application of feed additive |
| CN107410761A (en) * | 2017-06-09 | 2017-12-01 | 众合发(北京)生物科技发展有限公司 | One kind is used to improve aquatic livestock immunity and somatotrophic immunopotentiator |
| CN108669311A (en) * | 2018-04-24 | 2018-10-19 | 扬州中微生物技术有限公司 | A kind of preparation method of low molecular weight feed copper alginate |
| CN113563492A (en) * | 2021-08-16 | 2021-10-29 | 中北大学 | Molecular type low-ester copper pectin and preparation method thereof |
-
2009
- 2009-04-16 CN CN200910097724A patent/CN101530167A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102835610A (en) * | 2012-09-27 | 2012-12-26 | 淮阴工学院 | Feed additive for broiler chickens and preparation method thereof |
| CN103005212A (en) * | 2012-12-26 | 2013-04-03 | 浙江大学 | Feed additive for improving intestinal functions of piglets and application of feed additive |
| CN107410761A (en) * | 2017-06-09 | 2017-12-01 | 众合发(北京)生物科技发展有限公司 | One kind is used to improve aquatic livestock immunity and somatotrophic immunopotentiator |
| CN108669311A (en) * | 2018-04-24 | 2018-10-19 | 扬州中微生物技术有限公司 | A kind of preparation method of low molecular weight feed copper alginate |
| CN113563492A (en) * | 2021-08-16 | 2021-10-29 | 中北大学 | Molecular type low-ester copper pectin and preparation method thereof |
| CN113563492B (en) * | 2021-08-16 | 2022-12-02 | 中北大学 | Molecular type low-ester copper pectin and preparation method thereof |
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Open date: 20090916 |