CN103005212A - Feed additive for improving intestinal functions of piglets and application of feed additive - Google Patents

Feed additive for improving intestinal functions of piglets and application of feed additive Download PDF

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Publication number
CN103005212A
CN103005212A CN2012105737763A CN201210573776A CN103005212A CN 103005212 A CN103005212 A CN 103005212A CN 2012105737763 A CN2012105737763 A CN 2012105737763A CN 201210573776 A CN201210573776 A CN 201210573776A CN 103005212 A CN103005212 A CN 103005212A
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China
Prior art keywords
chitosan
copper
selenium
piglings
feed
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CN2012105737763A
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Chinese (zh)
Inventor
韩新燕
马原菲
钊守梅
李云涛
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Zhejiang University ZJU
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Zhejiang University ZJU
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Priority to CN2012105737763A priority Critical patent/CN103005212A/en
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Abstract

The invention discloses a feed additive for improving intestinal functions of piglets and an application of the feed additive. The feed additive is formed by combining and processing two or more of copper chitosan, zinc chitosan, ferrous chitosan and selenium chitosan according to a certain proportion; two or more inorganic microelements in the four combined substances do not need to be added into feed for the piglets; and 0.05%-2% of the feed additive provided by the invention is added to the piglet feed, so that the diarrhea rate of the piglets is remarkably reduced, the daily gain of the piglets is improved, the feed to gain ratio is reduced, and the disease resistance of the piglets is enhanced. The feed additive provided by the invention can be used for directly replacing common inorganic microelement additives, so that the problem of environment pollution caused by application of high copper and high zinc is avoided. Through a plurality of feeding experiments and laboratory detection, the feed additive has a remarkable effect, and is safe and non-toxic; and moreover, feeding animal products meet the requirements on national food sanitation.

Description

A kind of feed addictive and application thereof that improves intestines function of piglings
Technical field
The present invention relates to a kind of feed addictive and application thereof that improves intestines function of piglings.
Background technology
It is the key link of Swine Production that weanling pig produces.Since when wean be subjected to psychology, environment and nutrition stress impact, piglet usually shows that appetite is poor, the disorders of digestion, diarrhoea, growthing lag and efficiency of feed utilization are low etc. so-called " weaning syndrome of piglets ".Wean is easily destroyed the intestinal villi of piglet by bacterium and diet, thereby impact is to the abilities of digestive and absorption of nutriment.Behind the weaned piglet, change suddenly the picked-up solid feed into by picked-up liquid milk.When daily ration contained a large amount of grass family cereal, under the abrasive action of plant dry matter, intestinal villus very quick-wearing shortened, and fuzzy surface becomes flat ligule by high density finger-like, and crypts is deepened.This variation will continue 7 ~ 14 d, thereby reduce the absorption area of small intestine to nutrient, have a strong impact on secretion and the absorbability of its digestion process.Weanling pig is because gastrointestinal development is incomplete, and the digestive ferment hyposecretion adds the reasons such as immune system imperfection, premunition be poor, indigestion easily occurs and feed is produced irritated phenomenon, thereby cause diarrhoea, has a strong impact on the growth of piglet.
The correlative study of alleviating ablactation stress, raising intestines function of piglings is one of study hotspot of the worker that raises pigs at present.For example, in the weanling pig feed often with zinc oxide, copper sulphate form add high dose zinc (2000~2500mg/kg), copper (200~250mg/kg), have the effects such as the piglet of raising daily gain, feed intake, reduction diarrhea rate.But the use of high doses of copper zinc has brought many problems, as causes the wasting of resources, environmental pollution, copper poisoning, the absorption of disturbing other mineral elements, pig staple length skin dark etc.
Summary of the invention
In order to overcome the deficiencies in the prior art, the purpose of this invention is to provide a kind of feed addictive that improves intestines function of piglings.
It comprises in chitosan copper, chitosan-zn, chitosan ferrous, the chitosan selenium two or more, and compatibility processes in proportion.
Each material proportioning can be following a kind of technical scheme in the feed addictive of raising intestines function of piglings:
(1) chitosan copper: the chitosan-zn ratio is 1: 0.5~1 (respectively in copper, zinc);
(2) chitosan copper: chitosan ferrous ratio is 1: 0.5~1 (respectively in copper, iron);
(3) chitosan selenium: the chitosan copper ratio is 1: 1000~1500 (respectively in selenium, copper);
(4) chitosan-zn: chitosan ferrous ratio is 1: 0.5~1 (respectively in zinc, iron);
(5) chitosan selenium: the chitosan-zn ratio is 1: 1000~1500 (respectively in selenium, zinc);
(6) chitosan selenium: chitosan ferrous ratio is 1: 1000~1500 (respectively in selenium, iron);
(7) chitosan copper: chitosan-zn: chitosan ferrous ratio is 1: 0.5~1: 0.5~1 (respectively in copper, zinc, iron);
(8) chitosan selenium: chitosan copper: the chitosan-zn ratio is 1: 1000~1500: 1000~1500 (respectively in selenium, copper, zinc);
(9) chitosan selenium: chitosan copper: chitosan ferrous ratio is 1: 1000~1500: 1000~1500 (respectively in selenium, copper, iron);
(10) chitosan selenium: chitosan copper: chitosan-zn: chitosan ferrous ratio is 1: 1000~1500: 1000~1500: 1000~1500 (respectively in selenium, copper, zinc, iron).
A kind of application of feed addictive of described raising intestines function of piglings, described feed addictive is made dry powder-shaped, add in mixed feed, concentrate feed, the premix, mix, the mass percentage content that described feed addictive addition accounts for mixed feed is 0.05%~2%.
Beneficial effect of the present invention:
Set about from the alimentary canal physilogical characteristics of piglet, utilize the physicochemical property of shitosan, multiple material with raising function of intestinal canal and body's immunity is carried out reasonable compatibility, thereby successfully developed a kind of feed addictive that improves intestines function of piglings.Use the feed addictive of raising intestines function of piglings of the present invention, can significantly improve the average daily gain of weanling pig, reduce the material anharmonic ratio, significantly reduce diarrhea of weaned piglets.Can significantly improve rear 14 days duodenum contents of wean, the total protease of pancreas, amylase, tryptic activity, significantly improve two all intestinal villus height after the wean, reduce the crypts degree of depth.Can obviously improve the secretion of casing slime sIgA, reduce the apoptosis of small intestine cells, thereby improve function of intestinal canal, improve it to the absorption of nutriment, promote growth, have significant economic benefit and ecological benefits, have a extensive future.
In pig starter feed, add the feed addictive of 0.05%~2% raising intestines function of piglings of the present invention, can significantly reduce the diarrhea rate of piglet, improve daily gain, reduce the material anharmonic ratio, strengthen piglet disease-resistant power.The feed addictive of raising intestines function of piglings of the present invention can directly substitute inorganic microelement additive commonly used, avoids the problem of environmental pollution that brings in response to high-copper, Gao Xin etc.Through repeatedly feeding experiment and laboratory detection, this additive effect is remarkable, safety non-toxic, and the animal product of feeding meets the state food hygienic requirements.
The specific embodiment
The present invention is further illustrated below in conjunction with embodiment, but embodiments of the present invention are not limited to following several embodiment.
A kind of feed addictive that improves intestines function of piglings comprises in chitosan copper, chitosan-zn, chitosan ferrous, the chitosan selenium two or more.
Described chitosan copper: the mass ratio of chitosan-zn is 1: 0.5~1.
Described chitosan copper: chitosan ferrous mass ratio is 1: 0.5~1.
Described chitosan selenium: the mass ratio of chitosan copper is 1: 1000~1500.
Described chitosan-zn: chitosan ferrous mass ratio is 1: 0.5~1.
Described chitosan selenium: the chitosan-zn mass ratio is 1: 1000~1500.
Described chitosan selenium: chitosan ferrous mass ratio is 1: 1000~1500
Described chitosan copper: chitosan-zn: chitosan ferrous mass ratio is 1: 0.5~1: 0.5~1.
Described chitosan selenium: chitosan copper: the chitosan-zn mass ratio is 1: 1000~1500: 1000~1500.
Described chitosan selenium: chitosan copper: chitosan ferrous mass ratio is 1: 1000~1500: 1000~1500.
Described chitosan selenium: chitosan copper: chitosan-zn: chitosan ferrous mass ratio is 1: 1000~1500: 1000~1500: 1000~1500.
The feed addictive that improves intestines function of piglings is dry powder-shaped, during application this powder is added in mixed feed, concentrate feed, the premix, can need not to add in addition corresponding inorganic microelement additive, evenly mix, the mass percentage content that addition accounts for mixed feed is 0.05%~2%.
Embodiment 1
Chitosan copper, two kinds of materials of chitosan-zn are made up than 1: 0.5 ratio with copper zinc, evenly mix, obtain a kind of feed addictive that improves intestines function of piglings.
Embodiment 2
Chitosan copper, two kinds of materials of chitosan-zn are made up than 1: 1 ratio with copper zinc, evenly mix, obtain a kind of feed addictive that improves intestines function of piglings.
Embodiment 3
Chitosan copper, chitosan ferrous two kinds of materials are made up than 1: 0.5 ratio with copper iron, evenly mix, obtain a kind of feed addictive that improves intestines function of piglings.
Embodiment 4
Chitosan copper, chitosan ferrous two kinds of materials are made up than 1: 1 ratio with copper iron, evenly mix, obtain a kind of feed addictive that improves intestines function of piglings.
Embodiment 5
Chitosan selenium, two kinds of materials of chitosan copper are made up than 1: 1000 ratio with selenium copper, evenly mix, obtain a kind of feed addictive that improves intestines function of piglings.
Embodiment 6
Chitosan selenium, two kinds of materials of chitosan copper are made up than 1: 1500 ratio with selenium copper, evenly mix, obtain a kind of feed addictive that improves intestines function of piglings.
Embodiment 7
Chitosan-zn, chitosan ferrous two kinds of materials are made up than 1: 0.5 ratio with zinc-iron, evenly mix, obtain a kind of feed addictive that improves intestines function of piglings.
Embodiment 8
Chitosan-zn, chitosan ferrous two kinds of materials are made up than 1: 1 ratio with zinc-iron, evenly mix, obtain a kind of feed addictive that improves intestines function of piglings.
Embodiment 9
Chitosan selenium, two kinds of materials of chitosan-zn are made up than 1: 1000 ratio with selenium zinc, evenly mix, obtain a kind of feed addictive that improves intestines function of piglings.
Embodiment 10
Chitosan selenium, two kinds of materials of chitosan-zn are made up than 1: 1500 ratio with selenium zinc, evenly mix, obtain a kind of feed addictive that improves intestines function of piglings.
Embodiment 11
Chitosan selenium, chitosan ferrous two kinds of materials are made up than 1: 1000 ratio with ferroselenium, evenly mix, obtain a kind of feed addictive that improves intestines function of piglings.
Embodiment 12
Chitosan selenium, chitosan ferrous two kinds of materials are made up than 1: 1500 ratio with ferroselenium, evenly mix, obtain a kind of feed addictive that improves intestines function of piglings.
Embodiment 13
Ratio made up as 1: 0.5: 0.5 take copper zinc-iron ratio with chitosan copper, glycan zinc, chitosan ferrous three kinds of materials, evenly mixed, and obtained a kind of feed addictive that improves intestines function of piglings.
Embodiment 14
Ratio made up as 1: 1: 0.5 take copper zinc-iron ratio with chitosan copper, glycan zinc, chitosan ferrous three kinds of materials, evenly mixed, and obtained a kind of feed addictive that improves intestines function of piglings.
Embodiment 15
Ratio made up as 1: 0.5: 1 take copper zinc-iron ratio with chitosan copper, glycan zinc, chitosan ferrous three kinds of materials, evenly mixed, and obtained a kind of feed addictive that improves intestines function of piglings.
Embodiment 16
Ratio made up as 1: 1000: 1000 take selenium copper zinc ratio with chitosan selenium, chitosan copper, three kinds of materials of glycan zinc, evenly mixed, and obtained a kind of feed addictive that improves intestines function of piglings.
Embodiment 17
Ratio made up as 1: 1500: 1000 take selenium copper zinc ratio with chitosan selenium, chitosan copper, three kinds of materials of glycan zinc, evenly mixed, and obtained a kind of feed addictive that improves intestines function of piglings.
Embodiment 18
Ratio made up as 1: 1000: 1500 take selenium copper zinc ratio with chitosan selenium, chitosan copper, three kinds of materials of glycan zinc, evenly mixed, and obtained a kind of feed addictive that improves intestines function of piglings.
Embodiment 19
Ratio make up as 1: 1000: 1000 take selenium copper iron ratio with the ferrous three kinds of materials of chitosan selenium, chitosan copper, glycan, and evenly mixing obtains a kind of feed addictive that improves intestines function of piglings.
Embodiment 20
Ratio make up as 1: 1500: 1000 take selenium copper iron ratio with the ferrous three kinds of materials of chitosan selenium, chitosan copper, glycan, and evenly mixing obtains a kind of feed addictive that improves intestines function of piglings.
Embodiment 21
Ratio make up as 1: 1000: 1500 take selenium copper iron ratio with the ferrous three kinds of materials of chitosan selenium, chitosan copper, glycan, and evenly mixing obtains a kind of feed addictive that improves intestines function of piglings.
Embodiment 22
With the ferrous four kinds of materials of chitosan selenium, chitosan copper, chitosan-zn, glycan take selenium copper zinc-iron ratio as 1: 1000: 1000: the combination of 1000 ratios, evenly mix, obtain a kind of feed addictive that improves intestines function of piglings.
Embodiment 23
With the ferrous four kinds of materials of chitosan selenium, chitosan copper, chitosan-zn, glycan take selenium copper zinc-iron ratio as 1: 1000: 1500: the combination of 1000 ratios, evenly mix, obtain a kind of feed addictive that improves intestines function of piglings.
Embodiment 24
With the ferrous four kinds of materials of chitosan selenium, chitosan copper, chitosan-zn, glycan take selenium copper zinc-iron ratio as 1: 1000: 1000: the combination of 1500 ratios, evenly mix, obtain a kind of feed addictive that improves intestines function of piglings.
Embodiment 25
With the ferrous four kinds of materials of chitosan selenium, chitosan copper, chitosan-zn, glycan take selenium copper zinc-iron ratio as 1: 1000: 1500: the combination of 1500 ratios, evenly mix, obtain a kind of feed addictive that improves intestines function of piglings.
Embodiment 26
With the ferrous four kinds of materials of chitosan selenium, chitosan copper, chitosan-zn, glycan take selenium copper zinc-iron ratio as 1: 1500: 1500: the combination of 1500 ratios, evenly mix, obtain a kind of feed addictive that improves intestines function of piglings.
Embodiment 27
In the piglet diet of 28 ages in days wean, add the feed addictive of 0.2% raising intestines function of piglings of the present invention, wherein chitosan-containing zinc, chitosan ferrous two kinds of materials, the zinc-iron ratio is 1: 1, carries out by a definite date 30 days feeding experiment.The measurement result of young milk piglet daily gain, material anharmonic ratio sees Table 1.
Table 1 function of intestinal canal conditioning agent is on the impact of Growth Performance of Weaning Piglets
Project Control group Test group
Starting weight 7.24±0.26 7.25±0.30
The end is heavy 15.6±2.31 b 18.01±2.42 a
Average daily gain 298.25±45.23 b 385.06±54.23 a
The material anharmonic ratio 1.75±0.10 a 1.58±0.11 b
The result shows, adds the function of intestinal canal conditioning agent and can make the weanling pig daily gain improve 29.11% (P<0.05), and the material anharmonic ratio reduces by 10.92% (P<0.05).
Embodiment 28
In the piglet diet of 21 ages in days wean, add the feed addictive of 0.3% raising intestines function of piglings of the present invention, two kinds of materials of chitosan-containing copper and chitosan-zn wherein, copper zinc ratio is 1: 1, carries out by a definite date 28 days feeding experiment.Diarrhea rate measurement result such as table 2.
Table .2 function of intestinal canal conditioning agent is on the impact of diarrhea of weaned piglets
Project Control group Test group
Diarrhea rate 11.68±2.31 a 4.12±0.61 b
The result shows, adds the function of intestinal canal conditioning agent and can make the diarrhea of weaned piglets rate reduce by 54.50% (P<0.01),
Embodiment 29
In the piglet diet of 21 ages in days wean, add the feed addictive of 0.5% raising intestines function of piglings of the present invention, wherein chitosan-containing selenium, chitosan copper, three kinds of materials of glycan zinc, and selenium copper zinc ratio is 1: 1000: 1000, carries out by a definite date 28 days feeding experiment.Impact on weanling pig intestinal villi height, the crypts degree of depth and height of naps/crypts degree of depth sees Table 3.
Table 3 function of intestinal canal conditioning agent is on the impact of weanling pig intestinal villi height, the crypts degree of depth
Project Control group Test group
Jejunum ? ?
Height of naps 421.53±24.25 b 441.38±14.21 a
The crypts degree of depth 274.49±12.27 a 200.51±16.81 b
Height of naps/crypts the degree of depth 1.54±0.03 b 2.21±0.06 a
Ileum ? ?
Height of naps 350.7±12.92 363.71±13.16
The crypts degree of depth 234.30±8.62 219.65±7.53
Height of naps/crypts the degree of depth 1.49±0.06 1.66±0.05
The result shows, adding the function of intestinal canal conditioning agent can make weanling pig jejunum villi height improve 4.7% (P<0.05), the crypts degree of depth reduces by 26.9% (P<0.05), height of naps/crypts degree of depth improves 43.5%26.9% (P<0.05), ileum height of naps, the crypts degree of depth are had no significant effect, but be improved trend.
Embodiment 30
In the piglet diet of 21 ages in days wean, add the feed addictive of 0.02% raising intestines function of piglings of the present invention, wherein chitosan-containing selenium, chitosan copper, three kinds of materials of glycan zinc, and selenium copper zinc ratio is 1: 1000: 1000, carries out by a definite date 28 days feeding experiment.
Embodiment 31
In the piglet diet of 21 ages in days wean, add the feed addictive of 2% raising intestines function of piglings of the present invention, wherein chitosan-containing selenium, chitosan copper, three kinds of materials of glycan zinc, and selenium copper zinc ratio is 1: 1000: 1000, carries out by a definite date 28 days feeding experiment.

Claims (10)

1. a feed addictive that improves intestines function of piglings is characterized in that, it comprises in chitosan copper, chitosan-zn, chitosan ferrous, the chitosan selenium two or more.
2. the feed addictive of raising intestines function of piglings according to claim 1 is characterized in that, described chitosan copper: the mass ratio of chitosan-zn is 1: 0.5~1; Or described chitosan copper: chitosan ferrous mass ratio is 1: 0.5~1; Or described chitosan selenium: the mass ratio of chitosan copper is 1: 1000~1500.
3. the feed addictive of raising intestines function of piglings according to claim 1 is characterized in that, described chitosan-zn: chitosan ferrous mass ratio is 1: 0.5~1.
4. the feed addictive of raising intestines function of piglings according to claim 1 is characterized in that, described chitosan selenium: the chitosan-zn mass ratio is 1: 1000~1500.
5. the feed addictive of raising intestines function of piglings according to claim 1 is characterized in that, described chitosan selenium: chitosan ferrous mass ratio is 1: 1000~1500.
6. the feed addictive of raising intestines function of piglings according to claim 1 is characterized in that, described chitosan copper: chitosan-zn: chitosan ferrous mass ratio is 1: 0.5~1: 0.5~1.
7. the feed addictive of raising intestines function of piglings according to claim 1 is characterized in that, described chitosan selenium: chitosan copper: the chitosan-zn mass ratio is 1: 1000~1500: 1000~1500.
8. the feed addictive of raising intestines function of piglings according to claim 1 is characterized in that, described chitosan selenium: chitosan copper: chitosan ferrous mass ratio is 1: 1000~1500: 1000~1500.
9. the feed addictive of raising intestines function of piglings according to claim 1 is characterized in that, described chitosan selenium: chitosan copper: chitosan-zn: chitosan ferrous mass ratio is 1: 1000~1500: 1000~1500: 1000~1500.
10. according to claim 1-9 application of the feed addictive of each described raising intestines function of piglings, it is characterized in that, described feed addictive is made dry powder-shaped, add in mixed feed, concentrate feed, the premix, mix, the mass percentage content that described feed addictive addition accounts for mixed feed is 0.05%~2%.
CN2012105737763A 2012-12-26 2012-12-26 Feed additive for improving intestinal functions of piglets and application of feed additive Pending CN103005212A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103749980A (en) * 2014-01-05 2014-04-30 浙江大学 Intestinal mucosa improving type selenium supplement, and preparation method and application thereof
CN106135696A (en) * 2016-07-02 2016-11-23 浙江大学 CS ZnO is as the application of intestine of young pigs mucosal immunity reinforcing agent

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101019607A (en) * 2006-02-13 2007-08-22 曲琪环 Feed additive capable of promoting animal's growth and its prpen
CN101530167A (en) * 2009-04-16 2009-09-16 浙江大学 Additive of organic copper feed and preparation method and use thereof
CN101530166A (en) * 2009-04-16 2009-09-16 浙江大学 Organic iron feedstuff additive and preparing method and use thereof
CN101530168A (en) * 2009-04-16 2009-09-16 浙江大学 Additive of organic zinc feed and preparation method and use thereof
CN101889634A (en) * 2010-06-24 2010-11-24 浙江大学 Organic selenium-supplementing feed additive and preparation and using method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101019607A (en) * 2006-02-13 2007-08-22 曲琪环 Feed additive capable of promoting animal's growth and its prpen
CN101530167A (en) * 2009-04-16 2009-09-16 浙江大学 Additive of organic copper feed and preparation method and use thereof
CN101530166A (en) * 2009-04-16 2009-09-16 浙江大学 Organic iron feedstuff additive and preparing method and use thereof
CN101530168A (en) * 2009-04-16 2009-09-16 浙江大学 Additive of organic zinc feed and preparation method and use thereof
CN101889634A (en) * 2010-06-24 2010-11-24 浙江大学 Organic selenium-supplementing feed additive and preparation and using method thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103749980A (en) * 2014-01-05 2014-04-30 浙江大学 Intestinal mucosa improving type selenium supplement, and preparation method and application thereof
CN103749980B (en) * 2014-01-05 2015-09-30 浙江大学 Improved-type Selenium supplement agent of intestinal mucosa and its production and use
CN106135696A (en) * 2016-07-02 2016-11-23 浙江大学 CS ZnO is as the application of intestine of young pigs mucosal immunity reinforcing agent
CN106135696B (en) * 2016-07-02 2019-11-05 浙江大学 Application of the CS-ZnO as intestine of young pigs mucosal immunity reinforcing agent

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Application publication date: 20130403