CN105726922A - Drug for treating peptic ulcer - Google Patents
Drug for treating peptic ulcer Download PDFInfo
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- CN105726922A CN105726922A CN201610233059.4A CN201610233059A CN105726922A CN 105726922 A CN105726922 A CN 105726922A CN 201610233059 A CN201610233059 A CN 201610233059A CN 105726922 A CN105726922 A CN 105726922A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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Abstract
The invention relates to a drug for treating peptic ulcer.The drug for treating the peptic ulcer is prepared from, by weight, 6 parts of white atractylodes rhizomes, 10 parts of poria cocos, 6 parts of lily, 6 parts of licorice roots, 12 parts of three-nerved spicebush roots, 10 parts of rhizoma curculiginis, 9 parts of flos albiziae, 8 parts of philippine flemingia roots, 15 parts of rhizoma belamcandae and 9 parts of Thymus proximus Serg.In the application of the drug, the white atractylodes rhizomes and the poria cocos can strengthen the middle warmer and benefit vital energy; the lily and the licorice roots regulate middle energizer and qi and support earth to inhibit wood; the three-nerved spicebush roots soothe the liver, harmonize the stomach, guide qi downward and relieve pain; the rhizoma curculiginis reinforces the kidney and spleen, nourishes kidney yang and removes cold-dampness; the flos albiziae and the philippine flemingia roots dispel melancholy, soothe the nerves, regulate the flow of vital energy, stimulate appetite, eliminate wind, promote blood circulation and stop pain; the rhizoma belamcandae clears away heat and toxic materials and achieves abductive dispersion of food stagnation; the Thymus proximus Serg regulates the middle warmer and eliminates dampness.The medicinal materials are combined for usage and jointly achieve the effects of warning the stomach, tonifying spleen, promoting qi to activate blood, soothing the liver and harmonizing the stomach.A clinical experiment proves that the drug can safely and effectively treat the peptic ulcer.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of medicine for treating peptic ulcer.
Background technology
Peptic ulcer refers mainly to betide the duodenal chronic ulcer of harmonization of the stomach, is a frequently-occurring disease, commonly encountered diseases.Ulcer be formed with various factors, wherein the Digestion of mucosa is the Fundamentals of ulcer by acidic gastric juice, hence obtains one's name.Any position of acidic gastric juice contact, such as distal esophagus, the postoperative anastomotic stoma of gastrointestinal anastomosis, jejunum and the Meckel diverticulum with ectopic gastric mucosa, most of ulcer betides duodenum stomach function regulating, therefore also known as taste-blindness rate.Primary disease is multiple is born in person between twenty and fifty, but aged patient is also not rare, gastric ulcer send out well the age about slower than duodenal ulcer 10 years；The female patient mean age is high than male.
The category such as primary disease ownership Chinese medicine " gastric abscess ", " noisy ", " feeling of fullness ".The pathogenesis of ulcer stimulates mainly due to seven emotions, is particularly worried angry, causes incoordination between the liver and stomach, and deficiency of the upper portion of the body wood is horizontal, qi depression to blood stasis, and chronic dietary does not save, overstrain internal injury, and disease does not heal for a long time, causes weakness of the spleen and stomach, disorder of QI and blood.
Clinical manifestation
Epigastrium pain is one of modal symptom of Peptic Ulcers, the common feature having rhythmicity, periodicity and chronicity, the character of pain is often dull pain, causalgia, distending pain, hunger pain or severe pain, based on the medium degree dull pain of paroxysmal, also there is persistence dull pain person, can be alkalescent medicine and food respite.The painful area of gastric ulcer is under xiphoid-process or to the left, and duodenal ulcer is then to the right, and rear wall penetrating ulcer pain can be radiated to thoracic vertebra district, back 7 ~ 12.The persistent period of each panic attacks is mostly 1 ~ 2 hour, also the sustainable a few days.The outbreak of pain has seasonality, most susceptible disease of general time of the year when autumn changes into winter, and gastric ulcer pain betides 1/2 ~ 2 hour after the meal, alleviates then through after the gastric emptying of 1 ~ 2 hour.Its rule is feed-comfortable-pain-comfortable.Duodenal ulcer pain Chang Yu outbreak in 2 ~ 4 hours after meal, just alleviates after continuing to feed next time, and its rule is feed-comfortable-pain, and hypnalgia of being everlasting is waken up.The outbreak of peptic ulcer can with symptoms such as belch, acid regurgitation, sialorrhea, Nausea and vomiting, the patient of about 10% ~ 25%, especially the classical symptom such as normal supreme abdominal pain of old people, but goes to a doctor with upper gastrointestinal hemorrhage or acute perforation.
The diagnosis of this disease relies primarily on health check-up and lab testing 1. health check-up, the many lefts under xiphoid-process of tenderness of gastric ulcer, and prepyloric ulcer is many in upper abdomen master or slightly to the right, and duodenal bulbar ulcer is fixed on the upper right side of umbilicus more；2. like alcove or niche under x-ray, refer to that the female of barium suspension filling ulcer is caused.Seeing in front, niche is rounded or oval, neat in edge.Annular lucent area is formed because of the inflammatory edema around ulcer.Lesser gastric curvature is more common in by the niche of gastric ulcer, and ulcer offside of being everlasting sees spastic stomach incisura.The niche of duodenal ulcer is common in bulb, generally little than the niche of stomach；3. the gastric acid secretion of gastric analysis patients w ith peptic ulcer disease normally or is slightly less than normal, and duodenal ulcer patients then more to be increased, especially with obvious with night on an empty stomach；4. the detection that HP infects, applies polymerase chain reaction,PCR (PCR) technical measurement HP-DNA.Antibacterial culturing is that diagnosis HP infects the most reliable method.
Drug therapy 1. antacid antacid can lower the acidity of Stomach duodenum, alleviating pain, promotes ulcer healing, divides soluble preparation and insolubility two class.Soluble preparation is mainly sodium bicarbonate, and because causing alkalosis, sodium storage is stayed, therefore many with other antacid mixing administration in a small amount.Insolubility antacid can be selected for gel aluminum hydroxide, Magnesium Trisilicate, magnesium oxide.2. this kind of medicine of histamine H2-receptor antagonist can compete H2 receptor with histamine, eliminates histamine and causes gastric acid secretion effect, commonly uses at present: cimetidine, ranitidine, famotidine；3. anticholinergic, vagus nerve can be suppressed to reduce gastric acid secretion, release smooth muscle and vasospasm, improve local nutrition and delay the gastric emptying time, thus in favourable food and antacid and the effect of gastric acid, but it makes gastrin secretion increase because delaying gastric emptying that the storage of gastric antrum portion can be caused to stay, therefore should not be used in gastric ulcer.This kind of medicine answers combined antacid to apply, and is preferred with sleeping first each 1 time to take medicine with before the meal 30 minutes ~ 1 hour.Conventional anticholinergic agents has: atropine, Semen daturae tincture, propantheline, Anisodamine, metoclopramide etc..4. treatment by Chinese herbs peptic ulcer can use traditional Chinese medical herbal treatment, and effectiveness comparison is desirable.Simultaneously it should be noted that diet and living habit.
Medical material involved in the present invention is all recorded in " China's book on Chinese herbal medicine " as seen.
Summary of the invention
It is desirable to provide a kind of medicine for treating peptic ulcer, by selecting suitable medical material and proportioning thereof, reach safely and effectively to cure the purpose of peptic ulcer.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of medicine for treating peptic ulcer, it is characterized in that, it is to be prepared from by the raw medicinal material of following weight proportion: the Rhizoma Atractylodis Macrocephalae 6 parts, 10 parts of Poria, Bulbus Lilii 6 parts, 6 parts of Radix Glycyrrhizae, the Radix Linderae 12 parts, Rhizoma Curculiginis 10 parts, Flos Albiziae 9 parts, a thousand pieces of gold fall 8 parts, 15 parts of female gold reed, intend enter in fragrant 9 parts.
Illustrate the method have the benefit that below in conjunction with theories of Chinese materia medica
It has been recognised by the inventors that peptic ulcer pathogenesis is angry owing to being worried, seven emotions stimulate, the liver failing to maintain the normal flow of QI, horizontal criminal's stomach internal organs；Stagnation of spleen-QI, dysfunction of the spleen in transportation and transformation；Intemperance of taking food or partially addicted to, impairing the spleen and stomach；Or damp and hot stop up in knot burnt, stomach film is impaired；And muscle power or mental work are excessive for a long time, impairment of the spleen consumption gas, transporting is sluggish, and QI and blood mistake is smooth, and stomach film is not given birth to.Spleen injury, clear YANG failing to ascend, YIN-fire pent-up is the basic pathogenesis of peptic ulcer.Therefore spleen invigorating helps fortune for principle for the treatment of, or assistant is with Qinghua, or holds concurrently with circulation of qi promoting, invigorates blood circulation.
The present invention uses: the Rhizoma Atractylodis Macrocephalae, Poria energy invigorating the spleen and replenishing QI spleen invigorating；Bulbus Lilii, Radix Glycyrrhizae adjust in gentle, hold up soil to press down wood；The Radix Linderae is soothing the liver drops stomach, pleasant pain relieving；Rhizoma Curculiginis returns kidney spleen kidney-replenishing dispelling cold and dampness；Flos Albiziae, a thousand pieces of gold pendant resolving stagnation for tranquilization, appetizing of regulating the flow of vital energy, pathogenic wind expelling promoting blood circulation and stopping pain；Female's gold reed heat-clearing and toxic substances removing, dyspepsia and intestinal stasis relieving；Intend enter in fragrant and middle damp eliminating.All medicines share, and play stomach warming spleen invigorating, promoting flow of QI and blood, the merit of dispersing the stagnated liver-QI for regulating the stomach altogether.
Below in conjunction with clinical laboratory data, beneficial effects of the present invention is described:
1, physical data
Inventor collects 52 example Peptic Ulcers between 2012 06 month-2013 years 06 month altogether.It is randomly divided into: treatment group 26 example, matched group 26 example.21 ~ 63 years old age, 48.3 years old mean age；The course of disease 1 ~ 5 year.The data such as two groups of sexes, age, courses of disease there was no significant difference, and has comparability.
Diagnostic criteria
1. the chronic course of disease, periodical attack, often relevant with season, Nervous and Mental Factors, improper diet；There are upper abdomen causalgia, dull pain, distending pain or dull pain during outbreak, can alleviate after taking alkalescent medicine.Typical case's gastric ulcer painful area is to the left under xiphoid-process, is apt to occur in half an hour to 2 hours after the meal；It is to the right that duodenal ulcer pain is positioned at midfield, is apt to occur in 3～4 hours after the meal or midnight, can alleviate after feed, often accompanies belch, acid regurgitation.
2. the visible niche of x-ray barium meal examination and mucosal fold concentrate sign, simple local tenderness, excitation or be deformed into indirect sign, are intended for diagnosis reference.
3. endoscopy: can Stomach duodenum find circular, oval, linear, not shaping or the Frost's Descent sample ulcer, bottom is smooth, is covered with white or canescence tongue, how neat edge is, swelling without nodositas, surrounding mucosa congestion and edema, visible pleat is concentrated to ulcer sometimes.Biopsy and cytohistology inspection can get rid of malignant change.
4. traditional Chinese medical science disease sees gastric abscess, feeling of fullness, abdominal distention, belch, poor appetite, and body of the tongue is light red, and white and greasy fur or yellow greasy, soft pulse is slided or stringy and rolling pulse.
Inclusive criteria is age 18 ~ 75 years old 1.；2. ulcer major diameter 5 ~ 20mm；3. single ulcer；4. without complication such as hemorrhage or pyloric obstructions；5. without severe cardiac, lung, Liver and kidney function infringement；6. unused proton pump inhibitor in nearly 2 weeks, H2 receptor blocking agent, antibiotic or secrete agent；7. without penicillin anaphylaxis history；8. non-pregnancy and women breast-feeding their children.
1. exclusion standard does not meet inclusive criteria, does not take medicine by regulation, it is impossible to judge curative effect, or data not umbra rings Outcome measure person；2. the women of gestation or age of sucking, and intended pregnancy or the women without contraception plan；3. it is likely to by reagent allergy sufferers；4. be unwilling partner (not the person of affecting the treatment by regulation medication) or the person that suffers from mental sickness.
2, Therapeutic Method
The capsule that the oral present invention specific embodiment 3 for the treatment of group prepares, every day 3 times.Treat 8 weeks.
Matched group is administered orally magnesium oxide, each 0.6g, every day 3 times；Ranitidine, 150mg/ time, every day 2 times.Treat 8 weeks.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterions of therapeutical effect
1. recovery from illness: gastric abscess and other transference cures, x-ray canel barium meal contrast examination or gastroscopy are normal, ulcer disappears；
2. effective: have a stomach-ache alleviation, attack times reduces, and other symptoms alleviate, and x-ray canel barium meal contrast examination or gastroscopy take a favorable turn, and ulcer stove reduces more than 50%；
3. invalid: symptom is without improvement, and x-ray canel barium meal contrast examination or gastroscopy are unchanged, and ulcer stove reduces less than 50%；
3.2 treatment statistical results are in Table 1.
1 liang of table group comparitive study
| Group | n | Recovery from illness | Effectively | Invalid | Effective percentage (%) | Obvious adverse reaction example |
| Treatment group | 26 | 22 | 2 | 2 | 92.31% | 0 |
| Matched group | 26 | 5 | 6 | 15 | 42.31% | 0 |
Visible, peptic ulcer can safely and effectively be treated by the medicine that the present invention prepares, and cure rate is high.
Detailed description of the invention
In order to be more fully understood that and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Weigh: the Rhizoma Atractylodis Macrocephalae 6 grams, 10 grams of Poria, Bulbus Lilii 6 grams, 6 grams of Radix Glycyrrhizae, the Radix Linderae 12 grams, Rhizoma Curculiginis 10 grams, Flos Albiziae 9 grams, a thousand pieces of gold fall 8 grams, 15 grams of female gold reed, intend enter in fragrant 9 grams；Add 8 times amount water, decoct 1.5 hours, filter；Filtering residue adds 6 times amount water, decocts 1 hour, filters；Merging filtrate, is concentrated into 120 grams, must meet the decoct of one day consumption of adult normal.
For treating peptic ulcer.Oral, daily once.
Embodiment 2
Weigh: the Rhizoma Atractylodis Macrocephalae 6 grams, 10 grams of Poria, Bulbus Lilii 6 grams, 6 grams of Radix Glycyrrhizae, the Radix Linderae 12 grams, Rhizoma Curculiginis 10 grams, Flos Albiziae 9 grams, a thousand pieces of gold fall 8 grams, 15 grams of female gold reed, intend enter in fragrant 9 grams；Add 10 times amount water, decoct 2 hours, filter；Filtering residue adds 8 times amount water, decocts 1.5 hours, filters；Merging filtrate, concentration, dry, packaging, the powder of one day consumption of adult normal must be met.
For treating peptic ulcer.Oral, every bu is taken for twice sooner or later.
Embodiment 3
Weigh: the Rhizoma Atractylodis Macrocephalae 6 grams, 10 grams of Poria, Bulbus Lilii 6 grams, 6 grams of Radix Glycyrrhizae, the Radix Linderae 12 grams, Rhizoma Curculiginis 10 grams, Flos Albiziae 9 grams, a thousand pieces of gold fall 8 grams, 15 grams of female gold reed, intend enter in fragrant 9 grams；Add 6 times amount water, decoct 3 times, decoct 1 hour every time, merge decoction liquor, concentration, dry, load capsule shells, the capsule of one day consumption of adult normal must be met.
For treating peptic ulcer.Oral, every bu morning, noon and afternoon take for three times.
Claims (4)
1. the medicine being used for treating peptic ulcer, it is characterized in that, it is to be prepared from by the raw medicinal material of following weight proportion: the Rhizoma Atractylodis Macrocephalae 6 parts, 10 parts of Poria, Bulbus Lilii 6 parts, 6 parts of Radix Glycyrrhizae, the Radix Linderae 12 parts, Rhizoma Curculiginis 10 parts, Flos Albiziae 9 parts, a thousand pieces of gold fall 8 parts, 15 parts of female gold reed, intend enter in fragrant 9 parts.
2. the medicine for treating peptic ulcer as claimed in claim 1, it is characterized in that, its preparation method is: weigh: the Rhizoma Atractylodis Macrocephalae 6 parts, 10 parts of Poria, Bulbus Lilii 6 parts, 6 parts of Radix Glycyrrhizae, the Radix Linderae 12 parts, Rhizoma Curculiginis 10 parts, Flos Albiziae 9 parts, a thousand pieces of gold fall 8 parts, 15 parts of female gold reed, intend enter in fragrant 9 parts；Add 8 times amount water, decoct 1.5 hours, filter；Filtering residue adds 6 times amount water, decocts 1 hour, filters；Merging filtrate, is concentrated into 120 parts, obtains decoct；Above-mentioned part each means weight portion.
3. the medicine for treating peptic ulcer as claimed in claim 1, it is characterized in that, its preparation method is: weigh: the Rhizoma Atractylodis Macrocephalae 6 parts, 10 parts of Poria, Bulbus Lilii 6 parts, 6 parts of Radix Glycyrrhizae, the Radix Linderae 12 parts, Rhizoma Curculiginis 10 parts, Flos Albiziae 9 parts, a thousand pieces of gold fall 8 parts, 15 parts of female gold reed, intend enter in fragrant 9 parts；Add 10 times amount water, decoct 2 hours, filter；Filtering residue adds 8 times amount water, decocts 1.5 hours, filters；Merging filtrate, concentration, dry, packaging, obtain powder；Above-mentioned part each means weight portion.
4. the medicine for treating peptic ulcer as claimed in claim 1, it is characterized in that, its preparation method is: weigh: the Rhizoma Atractylodis Macrocephalae 6 parts, 10 parts of Poria, Bulbus Lilii 6 parts, 6 parts of Radix Glycyrrhizae, the Radix Linderae 12 parts, Rhizoma Curculiginis 10 parts, Flos Albiziae 9 parts, a thousand pieces of gold fall 8 parts, 15 parts of female gold reed, intend enter in fragrant 9 parts；Add 6 times amount water, decoct 3 times, decoct 1 hour every time, merge decoction liquor, concentration, dry, load capsule shells, obtain capsule；Above-mentioned part each means weight portion.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610233059.4A CN105726922A (en) | 2016-04-15 | 2016-04-15 | Drug for treating peptic ulcer |
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| CN201610233059.4A CN105726922A (en) | 2016-04-15 | 2016-04-15 | Drug for treating peptic ulcer |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406793A (en) * | 2011-12-04 | 2012-04-11 | 许从玉 | Pharmaceutical composition for treating peptic ulcer |
| CN104547828A (en) * | 2015-01-11 | 2015-04-29 | 施伟杰 | Traditional Chinese medicine for treating peptic ulcer |
| CN105233127A (en) * | 2015-11-18 | 2016-01-13 | 宋云飞 | Medicine for treating peptic ulcer |
-
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- 2016-04-15 CN CN201610233059.4A patent/CN105726922A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406793A (en) * | 2011-12-04 | 2012-04-11 | 许从玉 | Pharmaceutical composition for treating peptic ulcer |
| CN104547828A (en) * | 2015-01-11 | 2015-04-29 | 施伟杰 | Traditional Chinese medicine for treating peptic ulcer |
| CN105233127A (en) * | 2015-11-18 | 2016-01-13 | 宋云飞 | Medicine for treating peptic ulcer |
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