CN102697924A - Nutmeg traditional Chinese medicinal preparation for treating diarrhea and preparation method thereof - Google Patents
Nutmeg traditional Chinese medicinal preparation for treating diarrhea and preparation method thereof Download PDFInfo
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Abstract
Description
技术领域 technical field
本发明属于中药领域，尤其涉及一种用于治疗腹泻的肉豆蔻中药制剂及制备方法。The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine preparation of nutmeg for treating diarrhea and a preparation method thereof.
背景技术 Background technique
腹泻，中医在《内经》中称腹泻为“泄”，汉唐时期多称为“下利”，宋代以后称为“泄泻”。根据腹泻的病因、发病部位、发病特点、粪便形状等，又分为：湿泄、火泄、暑泄、热泄、食泄、气泄；胃泄、小肠泄、大肠泄、肾泄、直肠泄；水泻、滑泻等。一般将大便溏薄者称为“泄”，下如水样者称为“泻”。腹泻不是一种独立的疾病，而是很多疾病的一个共同表现，它同时可伴有呕吐、发热、腹痛、腹胀、黏液便、血便等症状。伴有发热、腹痛、呕吐等常提示急性感染；伴大便带血、贫血、消瘦等需警惕肠癌；伴腹胀、食欲差等需警惕肝癌；伴水样便则需警惕霍乱弧菌感染。此外，腹泻还可引起脱水、营养不良，表现为皮肤干燥、眼球下陷、舌干燥、皮肤皱褶。肾虚指肾脏功能减弱，肾虚分肾阴虚和肾阳虚，需要根据不同的症状调治。肾虚型腹泻，肾之阴阳俱虚，肾气化生不足，症见滑精早泄，尿后滴沥不尽，小便次数多而清，腰膝酸软，听力减退，气短，四肢不温，脉细弱等，治以补肾为主。采用中医中药的手段来治疗腹泻疾病，标本兼顾，是一极待开发的渠道，治疗方面有其独到的效果。Diarrhea, Chinese medicine called diarrhea as "Xie" in the "Internal Classics", it was often called "Xiali" in the Han and Tang Dynasties, and it was called "Xiae" after the Song Dynasty. According to the etiology, location, characteristics, and shape of the diarrhea, diarrhea can be further divided into: damp diarrhea, fire diarrhea, heat diarrhea, heat diarrhea, food diarrhea, and gas diarrhea; gastric diarrhea, small intestinal diarrhea, large intestinal diarrhea, kidney diarrhea, and rectal diarrhea diarrhea; watery diarrhea, diarrhea, etc. Generally, those with loose stools are called "Xie", and those with watery stools are called "Xie". Diarrhea is not an independent disease, but a common manifestation of many diseases. It can also be accompanied by vomiting, fever, abdominal pain, abdominal distension, mucus stool, bloody stool and other symptoms. Accompanied by fever, abdominal pain, vomiting, etc. often indicate acute infection; accompanied by blood in the stool, anemia, weight loss, etc., should be alerted to intestinal cancer; accompanied by abdominal distension, poor appetite, etc., should be alerted to liver cancer; accompanied by watery stool, alerted to Vibrio cholerae infection. In addition, diarrhea can also cause dehydration and malnutrition, manifested as dry skin, sunken eyeballs, dry tongue, and skin wrinkles. Kidney deficiency refers to the weakening of kidney function. Kidney deficiency is divided into kidney yin deficiency and kidney yang deficiency, which need to be adjusted according to different symptoms. Kidney-deficiency diarrhea, deficiency of both yin and yang of the kidney, insufficient production of kidney qi, symptoms include premature ejaculation of sperm, incessant dribbling after urination, frequent and clear urination, soreness of the waist and knees, hearing loss, shortness of breath, lukewarm extremities, thready and weak pulse, etc. The main treatment is to invigorate the kidney. Adopting the means of traditional Chinese medicine to treat diarrheal disease, taking into account both specimens, is a channel waiting to be developed, and has its unique effect in treatment.
发明内容 Contents of the invention
本发明的目的就是为了克服已有技术的上述缺陷，提供一种具有配伍完善，无毒副作用，疗效可靠的治疗腹泻的肉豆蔻中药制剂及制备方法。The object of the present invention is to overcome the above-mentioned defects of the prior art, and provide a nutmeg traditional Chinese medicine preparation with perfect compatibility, no toxic and side effects, and reliable curative effect for treating diarrhea and a preparation method thereof.
为实现上述目的，本发明是通过以下技术方案实现的：To achieve the above object, the present invention is achieved through the following technical solutions:
治疗腹泻的肉豆蔻中药制剂，由以下重量份的中药原料制成：The nutmeg Chinese medicine preparation for treating diarrhea is made from the following Chinese medicine raw materials in parts by weight:
肉豆蔻200-400份、补骨脂200-400份、吴茱萸100-300份、乌梅100-300份、石榴皮100-300份。200-400 parts of nutmeg, 200-400 parts of psoralen, 100-300 parts of Evodia rutaecarpa, 100-300 parts of dark plum, 100-300 parts of pomegranate peel.
所述的治疗腹泻的肉豆蔻中药制剂，由以下重量份的中药原料制成：The nutmeg Chinese medicine preparation for treating diarrhea is made from the following Chinese medicine raw materials in parts by weight:
肉豆蔻300份、补骨脂300份、吴茱萸200份、乌梅200份、石榴皮200份。300 parts of nutmeg, 300 parts of psoralen, 200 parts of Evodia rutaecarpa, 200 parts of dark plum, and 200 parts of pomegranate peel.
所述的治疗腹泻的肉豆蔻中药制剂的制备方法，其制备方法为：The preparation method of the nutmeg traditional Chinese medicine preparation for the treatment of diarrhea, its preparation method is:
按比例称取上述中药原料肉豆蔻300份、补骨脂250份、吴茱萸200份、乌梅200份、石榴皮200份，清洗晾干，粉碎成颗粒，加水浸泡1.5小时，然后加水煎煮两次，第一次加原料药8倍量的水，武火煎沸后，再文火煎煮1-2小时，取煎液、滤过，第二次加原料药6倍量的水，煎煮0.5-1.5小时，取两次煎液，滤过，热封袋中，每袋180ml，高温灭菌，包装即得。Weigh 300 parts of nutmeg, 250 parts of psoralen, 200 parts of Evodia rutaecarpa, 200 parts of black plum, and 200 parts of pomegranate peel in proportion, wash and dry, crush into granules, add water to soak for 1.5 hours, and then add water to decoct twice For the first time, add 8 times the amount of water of the raw material drug, boil it with strong fire, then decoct it with a slow fire for 1-2 hours, take the decoction, filter it, add water 6 times the amount of the raw material drug for the second time, and decoct it for 0.5- After 1.5 hours, take two decoctions, filter, put in heat-sealed bags, 180ml per bag, sterilize at high temperature, and pack.
用法与用量：口服本发明中药制剂，每次180ml，每日2次，饭后半小时，4周为1个疗程。Usage and dosage: take the traditional Chinese medicine preparation of the present invention orally, 180ml each time, twice a day, half an hour after meals, 4 weeks is a course of treatment.
本发明原料药的药理作用如下，肉豆蔻：辛、温，归脾、大肠经，涩肠止泻、温中行气；补骨脂：苦、辛，大温。归肾、脾经，补肾壮阳、固精缩尿、温脾止泻；吴茱萸：辛、苦，热、有小毒，归肝、脾、胃经，散寒止痛、疏肝下气、燥湿降逆；乌梅：酸、平，归肝、脾、肺、大肠经，敛肺止咳、涩肠止泻、安蛔止痛、生津止渴；石榴皮：性温、味酸、味涩，入胃经、大肠经，涩肠止泻杀虫；诸药共奏温肾健脾、固涩止泻之功，本发明的中药制剂对肾虚型腹泻患者有显著治疗效果，可迅速缓解黎明之前腹痛，肠鸣腹泻，泻后则安，形寒肢冷，腰腿酸软的症状，本制剂无毒副作用，治疗效果显著，从根本上解除了患者的痛苦。The pharmacological action of crude drug of the present invention is as follows, Nutmeg: pungent, warm, returns spleen, large intestine meridian, astringent bowel stops diarrhea, warms middle-JIAO promoting qi; Psoraleae: bitter, pungent, great temperature. Returns to the kidney, spleen meridian, nourishes the kidney and strengthens yang, strengthens essence and reduces urination, warms the spleen and relieves diarrhea; Evodia rutaecarpa: pungent, bitter, hot, slightly poisonous, returns to the liver, spleen, and stomach meridian, dispels cold and relieves pain, soothes the liver and lowers qi, and dries dampness Jiangni; dark plum: sour, flat, returns to liver, spleen, lung, large intestine meridian, astringes lungs to relieve cough, astringent intestines to relieve diarrhea, soothes ascariasis and relieve pain, promotes body fluid and quenches thirst; pomegranate peel: warm in nature, sour and astringent, enters the stomach meridian, large intestine meridian, astringent intestine, antidiarrheal and insecticidal; all medicines have played the role of warming the kidney and invigorating the spleen, solidifying astringent and antidiarrheal. The traditional Chinese medicine preparation of the present invention has a significant therapeutic effect on patients with diarrhea due to kidney deficiency, and can quickly relieve abdominal pain before dawn. Boborygia and diarrhea, calmness after diarrhea, cold body and cold limbs, soreness and weakness of the waist and legs, this preparation has no toxic and side effects, and the treatment effect is remarkable, which fundamentally relieves the pain of the patient.
具体实施方式Detailed ways
实施例l：Embodiment 1:
中药原料：肉豆蔻300份、补骨脂300份、吴茱萸200份、乌梅200份、石榴皮200份。Chinese medicine raw materials: 300 parts of nutmeg, 300 parts of psoralen, 200 parts of Evodia rutaecarpa, 200 parts of dark plum, and 200 parts of pomegranate peel.
制备方法：按比例称取上述中药原料肉豆蔻300份、补骨脂250份、吴茱萸200份、乌梅200份、石榴皮200份，清洗晾干，粉碎成颗粒，加水浸泡1.5小时，然后加水煎煮两次，第一次加原料药8倍量的水，武火煎沸后，再文火煎煮1-2小时，取煎液、滤过，第二次加原料药6倍量的水，煎煮0.5-1.5小时，取两次煎液，滤过，热封袋中，每袋180ml，高温灭菌，包装即得。Preparation method: Weigh 300 parts of nutmeg, 250 parts of psoralen, 200 parts of Evodia rutaecarpa, 200 parts of black plum, and 200 parts of pomegranate peel in proportion, wash and dry, crush into granules, add water to soak for 1.5 hours, and then add water to fry Boil twice, add 8 times the amount of water of the raw material for the first time, decoct with a strong fire for 1-2 hours, take the decoction, filter, add water 6 times the amount of the raw material for the second time, and decoct Boil for 0.5-1.5 hours, take two decoctions, filter, put in heat-sealed bags, 180ml per bag, sterilize at high temperature, and pack.
实施例2Example 2
中药原料：肉豆蔻400份、补骨脂400份、吴茱萸300份、乌梅300份、石榴皮300份。Chinese medicine raw materials: 400 parts of nutmeg, 400 parts of psoralen, 300 parts of Evodia rutaecarpa, 300 parts of dark plum, and 300 parts of pomegranate peel.
制备方法：按比例称取上述中药原料肉豆蔻400份、补骨脂400份、吴茱萸300份、乌梅300份、石榴皮300份，清洗晾干，粉碎成颗粒，加水浸泡1.5小时，然后加水煎煮两次，第一次加原料药8倍量的水，武火煎沸后，再文火煎煮1-2小时，取煎液、滤过，第二次加原料药6倍量的水，煎煮0.5-1.5小时，取两次煎液，滤过，热封袋中，每袋180ml，高温灭菌，包装即得。Preparation method: Weigh 400 parts of nutmeg, 400 parts of psoralen, 300 parts of Evodia rutaecarpa, 300 parts of black plum, and 300 parts of pomegranate peel in proportion, wash and dry, crush into granules, add water to soak for 1.5 hours, and then add water to fry Boil twice, add 8 times the amount of water of the raw material for the first time, decoct with a strong fire for 1-2 hours, take the decoction, filter, add water 6 times the amount of the raw material for the second time, and decoct Boil for 0.5-1.5 hours, take two decoctions, filter, put in heat-sealed bags, 180ml per bag, sterilize at high temperature, and pack.
实施例3：Example 3:
中药原料：肉豆蔻200份、补骨脂200份、吴茱萸100份、乌梅100份、石榴皮100份。Chinese medicine raw materials: 200 parts of nutmeg, 200 parts of psoraleae, 100 parts of Evodia rutaecarpa, 100 parts of dark plum, and 100 parts of pomegranate peel.
制备方法：按比例称取上述中药原料肉豆蔻200份、补骨脂200份、吴茱萸100份、乌梅100份、石榴皮100份，清洗晾干，粉碎成颗粒，加水浸泡1.5小时，然后加水煎煮两次，第一次加原料药8倍量的水，武火煎沸后，再文火煎煮1-2小时，取煎液、滤过，第二次加原料药6倍量的水，煎煮0.5-1.5小时，取两次煎液，滤过，热封袋中，每袋180ml，高温灭菌，包装即得。Preparation method: Weigh 200 parts of nutmeg, 200 parts of psoralen, 100 parts of Evodia rutaecarpa, 100 parts of black plum, and 100 parts of pomegranate peel in proportion, wash and dry, crush into granules, add water to soak for 1.5 hours, and then add water to fry Boil twice, add 8 times the amount of water of the raw material for the first time, decoct with a strong fire for 1-2 hours, take the decoction, filter, add water 6 times the amount of the raw material for the second time, and decoct Boil for 0.5-1.5 hours, take two decoctions, filter, put in heat-sealed bags, 180ml per bag, sterilize at high temperature, and pack.
实施例4：Example 4:
临床试验Clinical Trials
1）一般资料：1) General Information:
采用本发明中药制剂共治疗55例患者，其中男28例，女27例；年龄15-70岁,平均42.5岁；病程3～10年。A total of 55 patients were treated with the traditional Chinese medicine preparation of the present invention, including 28 males and 27 females; aged 15-70 years, with an average of 42.5 years; the course of disease was 3-10 years.
2）诊断标准：主症：黎明之前腹痛，肠鸣腹泻，泻后则安，形寒肢冷，腰腿酸软，舌淡，脉沉细。2) Diagnostic criteria: Main symptoms: Abdominal pain before dawn, borborygmus and diarrhea, calm after diarrhea, coldness of body and limbs, soreness of waist and legs, pale tongue, deep thready pulse.
3）治疗方法：口服本发明实施例1中药汤剂，每次180ml，每日2次，饭后半小时，4周为1个疗程，1个月为1个疗程,连用2个疗程后停药,全面判定疗效,3个月后随访,统计复发情况。3) Treatment method: Orally take the traditional Chinese medicine decoction of Example 1 of the present invention, 180ml each time, twice a day, half an hour after meals, 4 weeks as a course of treatment, 1 month as a course of treatment, stop after 2 consecutive courses of treatment The curative effect was judged comprehensively, followed up after 3 months, and the recurrence was counted.
4）疗效评价标准：4) Evaluation criteria for curative effect:
痊愈：症状全部消失，随访3个月无复发；Recovery from illness: all the symptoms disappeared, and there was no recurrence after 3 months of follow-up;
有效：症状明显减轻，仅存1～2个轻微腹部症状，不影响正常工作生活或治疗期间症状基本消失，随访期间有复发者；Effective: Symptoms are significantly relieved, only 1 or 2 mild abdominal symptoms remain, which do not affect normal work and life or symptoms basically disappear during treatment, and there are relapses during follow-up;
无效：未达到有效标准。Invalid: The effective standard has not been met.
5）治疗结果：患者55例病例中，经2个疗程治疗，其中痊愈37例，有效13例，无效5例，总有效率达90％。5) Treatment results: Among the 55 cases of patients, after 2 courses of treatment, 37 cases were cured, 13 cases were effective, and 5 cases were ineffective, with a total effective rate of 90%.
实施例5：Example 5:
典型病例：任某，32岁，女，黎明之前腹痛，肠鸣腹泻，泻后则安，形寒肢冷，腰腿酸软，舌淡，脉沉细，服用实施例1的中药制剂1周见效，2个疗程痊愈。Typical case: Ren Mou, 32 years old, female, had abdominal pain before dawn, borborygmus and diarrhea, then calmed down after diarrhea, cold and cold limbs, sore waist and legs, pale tongue, deep and thready pulse, took the traditional Chinese medicine preparation of Example 1 for 1 week and achieved results , 2 courses for the treatment of fully recovered.
实施例6：Embodiment 6:
典型病例：魏某，48岁，男，黎明之前腹痛，肠鸣腹泻，泻后则安，形寒肢冷，腰腿酸软，舌淡，脉沉细，服用实施例1的中药制剂1周见效，2个疗程痊愈。Typical case: Wei, 48 years old, male, had abdominal pain before dawn, borborygmus and diarrhea, then calmed down after diarrhea, cold and cold extremities, sore waist and legs, pale tongue, deep and thready pulse, took the traditional Chinese medicine preparation of Example 1 for 1 week and achieved results , 2 courses for the treatment of fully recovered.
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