CN105726657A - Traditional Chinese medicine eye drops for treating ocular inflammation and manufacturing method of eye drops - Google Patents

Abstract

The invention belongs to the field of medicine, and relates to traditional Chinese medicine eye drops for treating ocular inflammation and a manufacturing method of the eye drops, specifically to traditional Chinese medicine eye drops for treating ophthalmic diseases, such as viral keratitis, viral conjunctivitis, and acute or chronic conjunctivitis, and a manufacturing method of the eye drops. The eye drops comprise the following medicine components, by weight part, 10-30 parts of isatis roots, 10-50 parts of folium isatidis, 5-10 parts of white chrysanthemum flowers, 2-3 parts of borneol, 5-8 parts of honeysuckle flowers, 3-5 parts of pearl powder, 3-5 parts of mint, 10-15 parts of hebra senecionis scandentis, 0.1-1 part of vitamin A, and 0.1-1 part of vitamin B12. The adopted medicines conform to regulations of Pharmacopoeia of the People's Republic of China, and are safe and reliable. The medicines match each other and have the efficacy of resisting inflammation and allergy, and nourishing trigeminal nerves at corneal endings. The eye drops have characteristics of an accurate and quick curative effect, and high cure rate, and are free of side effects.

Description

A kind of traditional Chinese medicine eye drops treating eye inflammation and preparation method thereof

Technical field

The invention belongs to field of medicaments, relate to a kind of traditional Chinese medicine eye drops treating eye inflammation and preparation method thereof, be specifically related to a kind of treat traditional Chinese medicine eye drops of ophthalmic diseases such as viral keratitis, viral binding film is scorching, acute and chronic binding film is scorching and preparation method thereof.

Background technology

Viral keratitis, conjunctivitis are a kind of common ophthalmic diseasess, multiple virus cause, and infectiousness is extremely strong, it is easy to concurrent infection other diseases.Viral keratitis is the inflammation caused by viral pathogenesis original sense dye cornea.Cornea shallow-layer has abundant nervi trigeminus tip, therefore this disease often has obvious irritation, has photophobia, sheds tears, aches.This genus of cornea is transparent, once ill, then its transparency changes, and there is blurred vision in the normal main suit of patient.This disease is general falls ill along nervi trigeminus, and diseased region is invaded relatively deep, and it feels to go down, but because of the adjacent tissue of inflammatory stimulus keratopathy, therefore irritation is still more apparent.Viral keratitis, the course of disease herds length, more after and easily recur.Often can react with tunica uvea, iridocyclitis, hypopyon or secondary glaucoma even occur, be one of relatively conventional clinically diseases causing blindness.About there is symptom after the incubation period of 5～12 days in viral conjunctivitis, including conjunctival congestion, watery secretion, Ocular irritation and on WA palpebra inferior cling.There is symptom in normal eyes, and a usual lore starts.Many patients once contacted conjunctivitis person and/or suffered from respiratory tract infection person recently.Bulbar conjunctiva and palpebral conjunctiva are congested, and conjunctival follicle, preauricular lymph nodes enlargement and pain occurs in palpebral conjunctiva.Modal viral keratitis, conjunctivitis mainly have herpes simplex, herpes zoster, epidemic keratitis and conjunctivitis etc. clinically.

Herpes simplex keratitis, is modal viral keratitis, and its sickness rate is higher.Due to its have easy recurrence, protracted course of disease, to clinical characters such as Drug therapy opposings, be main diseases causing blindness, it has also become current ophthalmologists feels one of thorny oculopathy most.

Summary of the invention

According to above the deficiencies in the prior art, the present invention provides a kind of traditional Chinese medicine eye drops treating eye inflammation and preparation method thereof, and it is evident in efficacy, safe and reliable, have no side effect, and has wide potential applicability in clinical practice.

A kind of traditional Chinese medicine eye drops treating eye inflammation of the present invention, according to parts by weight meter, including following ingredient: Radix Isatidis 10～30 parts, Folium Isatidis 10～50 parts, Flos Chrysanthemi 5～10 parts, Borneolum Syntheticum 2～3 parts, Flos Lonicerae 5～8 parts, Margarita powder 3～5 parts, Herba Menthae 3～5 parts, Herba Hieracii Umbellati 10～15 parts, vitamin A 0.1～1 part and vitamin B₁₂0.1～1 part.

Wherein, it is preferable that scheme is as follows:

According to parts by weight meter, including following ingredient: Radix Isatidis 20 parts, Folium Isatidis 30 parts, Flos Chrysanthemi 5 parts, Borneolum Syntheticum 2 parts, Flos Lonicerae 8 parts, Margarita powder 3 parts, Herba Menthae 3 parts, Herba Hieracii Umbellati 12 parts, vitamin A 0.5 part and vitamin B₁₂1 part.

The preparation method of the traditional Chinese medicine eye drops for the treatment of eye inflammation of the present invention, during preparation, carries out according to following steps:

(1) first Radix Isatidis, Folium Isatidis, Flos Chrysanthemi, Flos Lonicerae, Margarita powder, Herba Menthae, Herba Hieracii Umbellati being added water 5000 milliliters, slow fire boils 1 hour, takes filtrate；

(2) residue adds water 5000 milliliters, and slow fire adds Borneolum Syntheticum after boiling 1 hour, and twice filtrate is merged after dissolving by Borneolum Syntheticum；

(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, after placing 24 hours, use filter paper filtering；

(4), after filtrate being waved to the greatest extent or reclaiming ethanol, vitamin A and vitamin B are added₁₂Powder, stirs evenly and adds distilled water again and obtain medicinal liquid to 1000～5000 milliliters；

(5) adjust medicinal liquid and be equivalent to the osmotic pressure of the sodium chloride that mass fraction is 0.8～1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%；

(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.

During use, every day 3～5 times, each 1～2.

Pharmacology analysis:

Radix Isatidis: heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving.Maculae caused by violent heat pathogen；High heat headache；Major part pestilence；Crimson tongue is purple dark, scarlet fever；Erysipelas；Mumps；Sore throat；Skin ulcer is swollen, carbuncle；Chickenpox；Measles；Hepatitis；Influenza, epidemic encephalitis, encephalitis b, pneumonia, coma tells nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash etc.；Epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis etc. can be prevented and treated.Various bacteria is had inhibitory action by Radix Isatidis, and bacillus subtilis, staphylococcus aureus, sarcine, escherichia coli, Bacillus typhi, Salmonella paratyphi, dysentery (will he, Freund) bacillus, bacillus enteritidis etc. are had inhibitory action in various degree by infusion；Acetone leachate also has similar effect, and to Hemolytic streptococcus effectively (all by agar aperture flat band method).The bacteriostasis of A type meningococcus and Bulbus Allii, Flos Lonicerae is similar.Infected by influenza PR8 strain and Jing Ke 68-1 strain have obvious inhibiting effect, and in vitro leptospiral effect killed by Radix Isatidis.

Folium Isatidis: cure mainly pyretic toxicity and send out the diseases such as speckle, erysipelas, laryngopharynx swelling and pain, aphtha of the mouth and tongue, sore and toxic.This medicine extensive use clinically in recent years, except available control above-mentioned all diseases except, can be used for again expectorant heat stagnation lung, cough up phlegm yellow thick；Especially it is usually used in popularity second encephalitis, both can be applied to prevention by single, Radix Bupleuri, Flos Lonicerae, Fructus Forsythiae, Radix Isatidis, Radix Scrophulariae, the Radix Rehmanniae etc., the pyretic toxicity that energy removing summer-heat edema caused by disorder of QI, battalion divide can be coordinated again, can use and control various encephalitis b, and comparatively suitable with partial heat type.Experiment in vitro shows: Folium Isatidis has broad ectrum antibiotic effect, and staphylococcus aureus, alpha streptococcus, meningococcus, Diplococcus pneumoniae, micrococcus catarrhalis, Bacillus typhi, escherichia coli, hemophilus influenza, diphtheria corynebacterium and dysentery bacterium are all had a degree of inhibitory action by its decoct.Encephalitis b virus, mumps virus, influenza virus are also had inhibitory action by Folium Isatidis. leptospira is also had killing action.

Flos Chrysanthemi: dissipate wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, dizziness of having a headache, conjunctival congestion and swelling pain, eyes is dim-sighted.

Borneolum Syntheticum: main dissipate stagnated fire, can deep heat, control infantile convulsion, expectorant fan, sore throat, swelling of the tongue, toothache, deafness, breath, conjunctival congestion cataract, pox poison cave in, parasite killing, hemorrhoid, expedite the emergence of, and property is walked and do not kept, also can granulation promoting pain relieving.So dissipate and easily exhaust, be that YIN-cold is also after all.

Flos Lonicerae: cold in nature, sweet in the mouth, enter lung, the heart, stomach warp, there is heat-clearing and toxic substances removing, antiinflammatory, qi-restoratives treat effect of wind, cure mainly disease under distension, epidemic febrile disease heating, the disease such as pyretic toxicity carbuncle and ulcer and tumor.It all has certain curative effect for diseases such as dizzy dizzy, xerostomia is made yearningly, hyperhidrosis unhappiness, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitiss.

Margarita powder: Margarita powder has the effect of heat-clearing and toxic substances removing, it is possible to clearing away liver-fire.The liver being in charge of the eyes, the raw nebula of hot-tempered then order, blurred vision.Finding through research, the selenium in Margarita powder can strengthen the conduction of optic nerve, improves eyesight status simultaneously；Zinc in trace element can promote the axonal transport of optic nerve, improves metabolism and the function of retina and retinal pigment epithelium.The Pharmacopoeia of the People's Republic of China describes: " Margarita has the function of improving eyesight removing nebula, cures mainly the raw nebula of order ", so Margarita powder is become " ophthalmology panacea " by a lot of scholar.

Herba Menthae: children's tender stem point can make vegetable edible, and herb can be used as medicine again, cure cold heating laryngalgia, headache, conjunctival congestion with ophthalmalgia, myalgia, and the diseases such as skin rubella is scratched where it itches, measles without adequate eruption are also effective to carbuncle, cellulitis, scabies, tinea, dermatitis rhus in addition.Herba Menthae contains menthol, this material can fresh breath there is the multiple property of medicine, stomachache, gallbladder problem such as spasm can be alleviated, also there is antisepsis and sterilization, diuresis, reduce phlegm, stomach invigorating and the effect such as aid digestion.

Herba Hieracii Umbellati: heat-clearing and toxic substances removing；Improving acuity of vision and removing nebula；Killing parasites for relieving itching.Main flow sense；Upper respiratory tract infection；Pneumonia；Acute tonsillitis；Rib adenitis；Acute enteritis；Bacillary dysentery；Icterohepatitis；Gallbladder exudative dermatitis is scorching；Acute urinary tract infection；Conjunctival congestion and swelling pain cataracta；Carbuncle furuncle poison；Erysipelas；Eczema；Dry and wet tinea skin ulcer；Trichomonal vaginitis；Burn and scald.

Vitamin A: also known as retinol (its aldehyde derivatives retinal) or antiophthalmic factor, is a unsaturated monohydric alcohol with alicyclic ring, including the retinol1 in animal food source, A2 two kinds, is that a class has the bioactive material of retinol.Retinol1 is stored in the liver of mammal and saltwater fish more, and dehydroretinol is often stored in the liver of fresh-water fishes.Owing to the specific activity of dehydroretinol is relatively low, so usually said vitamin A refers to retinol1.Vitamin A maintains normal visual performance, and vitamin A is sufficient, then soon and completely, dark adaptation is short for recovery time in the regeneration of rhodopsin.Vitamin A can treat xerophthalmia, keratomalacia, xerosis cutis and nyctalopia etc..Additionally, boiling hot, cold injury and ulcer is also effective in cure.

Vitamin B₁₂: the peripheral nerve of energy nutrition cornea, strengthen the resistance against diseases of cornea peripheral nerve, promote the rehabilitation of the state of an illness.

It is an advantage of the current invention that the medicine used meets Pharmacopoeia of People's Republic of China regulation, safety of medicine is reliable.All medicine phases and there is antiinflammatory antiallergic, the trifacial effect of nutrition cornea tip, the feature such as there is determined curative effect, instant effect, cure rate is high, have no side effect.

Outcome measure

1 clinical data

1.1 physical data treatment group 69 example herpes simplex keratitis patients are responsible for observing treatment (totally 76 eyes), wherein male 36 examples, female 33 example by special messenger in outpatient service；5～73 years old age；The course of disease 2～26 days, average 16.3 ± 6.36 days, 46 eyes of 76 eye middle-shallow layer herpes simplex keratitises, 27 eyes of Deep Stromal herpetic Keratitis.

1.2 Syndrome Differentiation of Traditional Chinese Medicines

1.2.1 shallow-layer herpes simplex keratitis (attacking type outside wind heat) patient have headache, shed tears, generate heat, the symptom such as aversion to wind, red tongue, yellow and thin fur, floating and rapid pulse.Pathological changes be limited only to epithelium or involve cornea before 1/3 hypothallus.

1.2.2 Deep Stromal herpetic Keratitis (in liver-fire vehement type) patient has symptom, red tongue, yellow and greasy fur, slippery and rapid pulse or the stringy and rapid pulse such as feeling of fullness in the head, conjunctival congestion, the vexed discomfort of rib.Pathological changes is as deep as cornea 1/2 hypothallus or descemet's membrane and endodermis, including ground pattern corneal ulcer, disciform keratitis and cornea uveitis.

1.2.3 convalescent period herpes simplex keratitis (lack of lung-YIN type) patient have that order is puckery, the look thing mixed dark symptoms such as weak, night sweat of accompanying, red tongue, few tongue thready and rapid pulse.In the pathological changes later stage, the state of an illness tends to stable, and corneal infiltration is clearly better Restoration stage.

2 Therapeutic Method

Every day 3～5 times, each 1～2.20 days courses for the treatment of, treat two courses for the treatment of.

2.1.6 1. criterion of therapeutical effect cures: shallow-layer herpes simplex keratitis is ulcer healing, and focal zone fluorescence rope is painted transfers feminine gender to；Deep Stromal herpetic Keratitis and convalescent period herpes simplex keratitis are except above-mentioned standard, in slit lamp tangent plane, hypothallus infiltration, edema disappear, do not thicken, descemet's membrane gauffer and aqueous flare disappear and 2. take a turn for the better: shallow-layer herpes simplex keratitis is the healing of ulcer part, focus reduces, and remains a little fluorescein colored spots.Deep layer and convalescent period herpes simplex keratitis are except above-mentioned standard, and in slit lamp tangent plane, hypothallus infiltration, edema alleviate, and corneal thickness is close to normal 3. invalid: the state of an illness is without changing or increasing the weight of.

3 therapeutic outcomes.

Three groups of cases are treated all with 20 days for 1 course for the treatment of, statistical result after two courses for the treatment of.Treatment group total effective rate is 97.10%；Refer to following table.

Model case is introduced

Song, man, 53 years old, right eye is red, bitterly, shed tears, aversion to wind 3 days.Check right vision 0.3, left vision 1.0, it has been found that cornea of right eye temporo side has shallow-layer branch sample to infiltrate, and fluorescent staining is painted, red tongue, yellow and thin fur, floating and rapid pulse, belong to and attack type outside wind heat.Through eye drop of the present invention in conjunction with substantially recovery from illness in 38 days.

Dong, female, 45 years old, left eye is red, bitterly, shed tears, aversion to wind, keep in dark place 5 days, accompany eyelid Mild edema.Check right vision 1.2, left vision 0.06, it has been found that there are the pattern infiltration of deep layer ground in cornea of left eye central authorities, and fluorescent staining is painted, red tongue, yellow and greasy fur, slippery and rapid pulse, belongs to vehement type in liver-fire.It is clearly better in conjunction with 28 days through eye drop of the present invention.

Detailed description of the invention

Below in conjunction with embodiment, the present invention will be further described.

Embodiment 1:

A kind of traditional Chinese medicine eye drops treating eye inflammation, according to parts by weight meter, including following ingredient: Radix Isatidis 20 parts, Folium Isatidis 30 parts, Flos Chrysanthemi 5 parts, Borneolum Syntheticum 2 parts, Flos Lonicerae 8 parts, Margarita powder 3 parts, Herba Menthae 3 parts, Herba Hieracii Umbellati 12 parts, vitamin A 0.5 part and vitamin B₁₂1 part.

Embodiment 2:

Embodiment 1 is prepared according to following steps:

(1) first Radix Isatidis, Folium Isatidis, Flos Chrysanthemi, Flos Lonicerae, Margarita powder, Herba Menthae, Herba Hieracii Umbellati being added water 5000 milliliters, slow fire boils 1 hour, takes filtrate；

(2) residue adds water 5000 milliliters, and slow fire adds Borneolum Syntheticum after boiling 1 hour, and twice filtrate is merged after dissolving by Borneolum Syntheticum；

(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, after placing 24 hours, use filter paper filtering；

(4), after filtrate being waved to the greatest extent or reclaiming ethanol, vitamin A and vitamin B are added₁₂Powder, stirs evenly and adds distilled water again and obtain medicinal liquid to 5000 milliliters；

(5) adjust medicinal liquid and be equivalent to the osmotic pressure of the sodium chloride that mass fraction is 0.8～1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%；

(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.

Claims (3)

1. the traditional Chinese medicine eye drops treating eye inflammation, it is characterized in that according to parts by weight meter, including following ingredient: Radix Isatidis 10～30 parts, Folium Isatidis 10～50 parts, Flos Chrysanthemi 5～10 parts, Borneolum Syntheticum 2～3 parts, Flos Lonicerae 5～8 parts, Margarita powder 3～5 parts, Herba Menthae 3～5 parts, Herba Hieracii Umbellati 10～15 parts, vitamin A 0.1～1 part and vitamin B₁₂0.1～1 part.

2. a kind of traditional Chinese medicine eye drops treating eye inflammation according to claim 1, it is characterized in that according to parts by weight meter, including following ingredient: Radix Isatidis 20 parts, Folium Isatidis 30 parts, Flos Chrysanthemi 5 parts, Borneolum Syntheticum 2 parts, Flos Lonicerae 8 parts, Margarita powder 3 parts, Herba Menthae 3 parts, Herba Hieracii Umbellati 12 parts, vitamin A 0.5 part and vitamin B₁₂1 part.

3. the preparation method of the traditional Chinese medicine eye drops of the treatment eye inflammation described in a claim 1, it is characterised in that during preparation, carry out according to following steps:

(1) first Radix Isatidis, Folium Isatidis, Flos Chrysanthemi, Flos Lonicerae, Margarita powder, Herba Menthae, Herba Hieracii Umbellati being added water 5000 milliliters, slow fire boils 1 hour, takes filtrate；

(2) residue adds water 5000 milliliters, and slow fire adds Borneolum Syntheticum after boiling 1 hour, and twice filtrate is merged after dissolving by Borneolum Syntheticum；

(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, after placing 24 hours, use filter paper filtering；

(4), after filtrate being waved to the greatest extent or reclaiming ethanol, vitamin A and vitamin B are added₁₂Powder, stirs evenly and adds distilled water again and obtain medicinal liquid to 1000～5000 milliliters；

(5) adjust medicinal liquid and be equivalent to the osmotic pressure of the sodium chloride that mass fraction is 0.8～1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%；

(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.