CN104107258A - Medicinal composition for treating viral keratitis - Google Patents
Medicinal composition for treating viral keratitis Download PDFInfo
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- CN104107258A CN104107258A CN201410350884.3A CN201410350884A CN104107258A CN 104107258 A CN104107258 A CN 104107258A CN 201410350884 A CN201410350884 A CN 201410350884A CN 104107258 A CN104107258 A CN 104107258A
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Abstract
The invention relates to a medicinal composition for treating viral keratitis. The medicinal composition is prepared from dandelion, lonicera japonica, folium isatidis, chrysanthemum, houttuynia cordata, borneol, scutellaria baicalensis, senecio scandens and artemisia apiacea; a fumigation method is adopted for treatment. The medicinal composition aims to provide the medicament for treating viral keratitis with an exact curative effect.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of pharmaceutical composition for the treatment of viral keratitis and preparation method thereof.
Background technology
Keratitis is the common eye surface diseases of clinical ophthalmology, and its feature is course of disease protracted course of disease, and easily outbreak repeatedly, serious for the infringement of visual function, is one of common diseases causing blindness of China.In recent years, along with the continuous upgrading of medicine, drug resistance constantly increases, and the therapeutic effect of keratitis is unsatisfactory, and the generation of keratitis is often because immunity of organisms is low, and much Chinese medicine can play centralizing function, regulates immunity.
Summary of the invention
Goal of the invention of the present invention is to provide a kind of new Chinese medicine for the treatment of viral keratitis and preparation method thereof, to remove patient's sufferings, creates good society and economic benefit.
Drug regimen raw material of the present invention is by weight ratio: Herba Taraxaci 130-170 part, Flos Lonicerae 140-220 part, Folium Isatidis 150-210 part, Flos Chrysanthemi 160-200 part, Herba Houttuyniae 130-180 part, Borneolum Syntheticum 100-140 part, Radix Scutellariae 110-150 part, Herba Senecionis Scandentis 100-150 part, Herba Artemisiae Annuae 110-130 part.
Preferably: 150 parts of Herba Taraxacis, 180 parts of Flos Loniceraes, 180 parts of Folium Isatidiss, 160 parts of Flos Chrysanthemis, 150 parts of Herba Houttuyniae, 120 parts of Borneolum Syntheticums, 130 parts of Radix Scutellariaes, 120 parts of Herba Senecionis Scandentiss, 120 parts of Herba Artemisiae Annuaes.
The preparation method of above pharmaceutical composition is: above 9 taste crude drug are mixed, add 5 times of decoctings of crude drug weight and boil 3 times, decoct 2 hours at every turn, filter, merging filtrate, leaches medicinal liquid, places standby.
The present invention is on Chinese medical theory basis, through a large amount of clinical practice screening gained.Its formula is simple, onset rapidly, anti-inflammation, evident in efficacy, short treating period, be difficult for recurrence.
Herba Taraxaci: heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.Modern pharmacy studies have shown that, Herba Taraxaci has antibacterial action, and staphylococcus aureus resistance bacterial strain, Hemolytic streptococcus are had to stronger bactericidal action.Diplococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus pyocyaneus, dysentery bacterium, Bacillus typhi etc. and micrococcus catarrhalis are also had to certain bactericidal action.
Flos Lonicerae: heat-clearing and toxic substances removing, wind-heat dissipating.Modern pharmacy studies have shown that, Flos Lonicerae contains the compositions such as chlorogenic acid, luteolin glycosides, the various pathogens such as Hemolytic streptococcus, staphylococcus aureus and upper respiratory tract infection Causative virus etc. are had to stronger restraint, in addition also can enhancing immunity, antiinflammatory, antipyretic etc.
Folium Isatidis: heat-clearing and toxic substances removing, cooling blood for hemostasis.Modern pharmacy studies have shown that, Folium Isatidis contains indigo glycoside, there is the effect of resisting pathogenic microbes, experiment in vitro shows, Folium Isatidis has broad ectrum antibiotic effect. its decoct all has inhibitory action to a certain degree to staphylococcus aureus, alpha streptococcus, meningococcus, Diplococcus pneumoniae, micrococcus catarrhalis, Bacillus typhi, escherichia coli, hemophilus influenza, diphtheria corynebacterium and dysentery bacterium etc., have in addition antiinflammatory, antipyretic, strengthen immune function.
Flos Chrysanthemi: loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.Modern pharmacy studies have shown that, Flos Chrysanthemi has antiviral effect, and foreign study scholar finds, Flos Chrysanthemi has inhibitory action in various degree to herpes simplex virus poliovirus and Measles virus.In addition, also there is the effects such as antiinflammatory, antitumor.
Herba Houttuyniae: heat-clearing and toxic substances removing, inducing diuresis to remove edema.Modern pharmacy studies have shown that, Herba Houttuyniae has the effects such as enhancing immunity, antibacterial, antiviral, antiinflammatory.
Borneolum Syntheticum: logical all keys, loose stagnated fire, removing nebula improving eyesight, reducing swelling and alleviating pain.Modern pharmacy studies have shown that, Borneolum Syntheticum contains dextro Borneolum Syntheticum, humulene, beta-elemene, caryophyllene etc., and the triterpenoid such as oleanolic acid, alphitolic acid, asiatic acid, Borneolum Syntheticum are aromatic, erythrodiol.There is good antibacterial, antiinflammatory action.
Radix Scutellariae: heat clearing and damp drying, removing heat from blood are antiabortive.Modern pharmacy studies have shown that, Radix Scutellariae has good antibacterial action, the antibacterials such as dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus pyocyaneus, staphylococcus, hemolytic vessel used to hold grain at the imperial sacrifice coccus, Diplococcus pneumoniae, diphtheria corynebacterium are all had to inhibitory action, and another Radix Scutellariae also has certain antivirus action.
Herba Senecionis Scandentis: heat-clearing and toxic substances removing, anti-inflammation, cooling blood for improving eyesight, killing parasites for relieving itching.Modern pharmacy studies have shown that, the effect such as that Herba Senecionis Scandentis has is antibacterial, anti-spirillum.
Herba Artemisiae Annuae: clearing away summer-heat, except steaming preventing the attack (or recurrence) of malaria.Modern pharmacy studies have shown that, Herba Artemisiae Annuae have good antibacterial action, in addition have parasiticide, antipyretic, regulate the effects such as immunity.
In order to show that medicine of the present invention has therapeutic effect to viral keratitis, the present invention has carried out following clinical experiment:
1 data and method
1.1 physical data
The object of observation is that in December, 2011～2013 are diagnosed as viral keratitis patient year June in the court, totally 58 examples, 81.Male 26 examples wherein, 34; Female's 32 examples, 47; 39.2 ± 10.1 years old mean age; ; Point-like infiltrates 48 of viral keratitis 33 examples, 19 of shallow-layer infiltrative type keratitis 15 examples, 14 of deep layer infiltrative type keratitis 10 examples.58 routine patients are divided into two groups at random, treatment group 27 examples, 40; Matched group 31 examples, 41.
1.2 diagnostic criterias and typing
1.2.1 diagnostic criteria: have flu, heating or specific predisposing factors, repeatedly outbreak; Corneal sensation is gone down, ciliary congestion; The corneal opacity, is dendroid, map shape or plate-like and changes; Fluorescein corneal dyeing "+".
1.2.2 typing: point-like infiltrative type: pathological changes is confined to epithelial layer, 33 48 of examples; Shallow-layer type: pathological changes is dendroid, map shape, 15 19 of examples; Deep-type: pathological changes is plate-like and substrate necrotic type, 10 14 of examples.
1.3 Therapeutic Method
Matched group gives the Therapeutic Method of conventional viral keratitis, comprises 1% atropine mydriasis, part and whole body symptomatic treatment.Treatment group conventional therapy simultaneously the medicinal liquid of use in conjunction medicine embodiment 1 of the present invention add in fumigating device and heat, with steam fumigating eye.2 times on the 1st, each 15min.
1.4 observation index
Observe the congested situation of vision, Ocular irritation symptom and cornea, by the inflammation signs such as slit lamp microscope observation corneal ulcer, edema infiltration, dp and aqueous flare, the place ahead empyema situation that disappears.
1.5 curative effect determinate standard
Cure: irritation disappears, and corneal infiltration all absorbs or forms nebula, kp "-", aqueous flare "-", fluorescent staining is negative.Take a turn for the better: symptom alleviates, and has a small amount of residual kp, and ulcer surface dwindles, shoals.
Invalid: sings and symptoms is unchanged or increase the weight of.
1.6 statistical method
The relatively employing χ for the treatment of group and matched group cure rate
2check, P < 0.05, for there being significant difference, has statistical significance.
2 results
Treatment group curative effect is better than matched group, and difference has statistical significance (P < 0.05), and the comparison of cure rate is in Table 1.
Table 1 treatment group and the comparison of matched group curative effect
Note: treatment group cure rate and matched group comparison, P < 0.05
By above-mentioned clinical trial certificate this method pharmaceutical composition, aspect treatment viral keratitis, there iing definite curative effect.
Specific embodiment
Embodiment 1
Herba Taraxaci 150g, Flos Lonicerae 180g, Folium Isatidis 180g, Flos Chrysanthemi 160g, Herba Houttuyniae 150g, Borneolum Syntheticum 120g, Radix Scutellariae 130g, Herba Senecionis Scandentis 120g, Herba Artemisiae Annuae 120g.
The preparation method of above pharmaceutical composition is: above 9 taste crude drug are mixed, add 5 times of decoctings of crude drug weight and boil 3 times, decoct 2 hours at every turn, filter, merging filtrate, leaches medicinal liquid, places standbyly, and treatment is to add hot smoking eye.
Embodiment 2
Herba Taraxaci 140g, Flos Lonicerae 200g, Folium Isatidis 160g, Flos Chrysanthemi 180g, Herba Houttuyniae 180g, Borneolum Syntheticum 100g, Radix Scutellariae 140g, Herba Senecionis Scandentis 150g, Herba Artemisiae Annuae 110g.
The preparation method of above pharmaceutical composition is: above 9 taste crude drug are mixed, add 5 times of decoctings of crude drug weight and boil 3 times, decoct 2 hours at every turn, filter, merging filtrate, leaches medicinal liquid, places standbyly, and treatment is to add hot smoking eye.
Embodiment 3
Herba Taraxaci 170g, Flos Lonicerae 150g, Folium Isatidis 200g, Flos Chrysanthemi 170g, Herba Houttuyniae 130g, Borneolum Syntheticum 140g, Radix Scutellariae 110g, Herba Senecionis Scandentis 100g, Herba Artemisiae Annuae 130g.
The preparation method of above pharmaceutical composition is: above 9 taste crude drug are mixed, add 5 times of decoctings of crude drug weight and boil 3 times, decoct 2 hours at every turn, filter, merging filtrate, leaches medicinal liquid, places standbyly, and treatment is to add hot smoking eye.
Claims (3)
1. a pharmaceutical composition for the treatment of viral keratitis, it is characterized in that according to weight portion meter, the raw material of making this pharmaceutical composition active component is: Herba Taraxaci 130-170 part, Flos Lonicerae 140-220 part, Folium Isatidis 150-210 part, Flos Chrysanthemi 160-200 part, Herba Houttuyniae 130-180 part, Borneolum Syntheticum 100-140 part, Radix Scutellariae 110-150 part, Herba Senecionis Scandentis 100-150 part, Herba Artemisiae Annuae 110-130 part.
2. a kind of pharmaceutical composition for the treatment of viral keratitis as claimed in claim 1, it is characterized in that according to weight portion meter, the raw material of making this pharmaceutical composition active component is: 150 parts of Herba Taraxacis, 180 parts of Flos Loniceraes, 180 parts of Folium Isatidiss, 160 parts of Flos Chrysanthemis, 150 parts of Herba Houttuyniae, 120 parts of Borneolum Syntheticums, 130 parts of Radix Scutellariaes, 120 parts of Herba Senecionis Scandentiss, 120 parts of Herba Artemisiae Annuaes.
3. a kind of preparation method for the treatment of the pharmaceutical composition of viral keratitis as claimed in claim 1 or 2, is characterized in that the method is: described 9 taste crude drug are mixed, add 5 times of decoctings of crude drug weight and boil 3 times, each decoction 2 hours, filters merging filtrate, leach medicinal liquid, place standby.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410350884.3A CN104107258A (en) | 2014-07-16 | 2014-07-16 | Medicinal composition for treating viral keratitis |
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| CN201410350884.3A CN104107258A (en) | 2014-07-16 | 2014-07-16 | Medicinal composition for treating viral keratitis |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770248A (en) * | 2016-04-21 | 2016-07-20 | 毕宏生 | Traditional Chinese medicine composition for treating keratitis as well as preparation method and application thereof |
| CN105816601A (en) * | 2016-04-21 | 2016-08-03 | 毕宏生 | Medicine composition for treating viral keratitis |
| CN106138216A (en) * | 2016-07-26 | 2016-11-23 | 戚金泽 | A kind of Chinese medicine preparation treating viral keratitis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1509741A (en) * | 2002-12-23 | 2004-07-07 | 上海中华制药厂 | Chinese medicinal preparation for preventing herpes virus and preparing method thereof |
| CN103169813A (en) * | 2013-04-10 | 2013-06-26 | 王文一 | Compound traditional Chinese medicine preparation for treating viral keratitis |
| CN103800485A (en) * | 2014-03-12 | 2014-05-21 | 马丽 | Traditional Chinese medicine preparation for treating herpes simplex keratitis |
-
2014
- 2014-07-16 CN CN201410350884.3A patent/CN104107258A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1509741A (en) * | 2002-12-23 | 2004-07-07 | 上海中华制药厂 | Chinese medicinal preparation for preventing herpes virus and preparing method thereof |
| CN103169813A (en) * | 2013-04-10 | 2013-06-26 | 王文一 | Compound traditional Chinese medicine preparation for treating viral keratitis |
| CN103800485A (en) * | 2014-03-12 | 2014-05-21 | 马丽 | Traditional Chinese medicine preparation for treating herpes simplex keratitis |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770248A (en) * | 2016-04-21 | 2016-07-20 | 毕宏生 | Traditional Chinese medicine composition for treating keratitis as well as preparation method and application thereof |
| CN105816601A (en) * | 2016-04-21 | 2016-08-03 | 毕宏生 | Medicine composition for treating viral keratitis |
| CN106138216A (en) * | 2016-07-26 | 2016-11-23 | 戚金泽 | A kind of Chinese medicine preparation treating viral keratitis |
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Application publication date: 20141022 |