CN105582186A - Traditional Chinese medicine for treating amyotrophic lateral sclerosis and preparation - Google Patents

Traditional Chinese medicine for treating amyotrophic lateral sclerosis and preparation Download PDF

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CN105582186A
CN105582186A CN201510908931.6A CN201510908931A CN105582186A CN 105582186 A CN105582186 A CN 105582186A CN 201510908931 A CN201510908931 A CN 201510908931A CN 105582186 A CN105582186 A CN 105582186A
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extract
chinese medicine
traditional chinese
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lateral sclerosis
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王沫学
葛建杰
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K2236/30—Extraction of the material
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention relates to a traditional Chinese medicine for treating amyotrophic lateral sclerosis and preparation. The traditional Chinese medicine is characterized by being prepared from, by weight, 0.02%-0.05% of common clubmoss herb extract, 0.02%-0.05% of rhizoma chuanxiong extract, 0.02%-0.05% of rhizoma panacis japonici extract, 0.02%-0.05% of extract of seeds of Chinese narcissus, 0.02%-0.05% of radix paeoniae rubra extract, 0.02%-0.05% of indigowoad leaf extract, 0.02%-0.05% of radix angelicae dahuricae extract, 0.2%-0.5% of tamariskoid spikemoss herb extract, 0.02%-0.05% of radix scrophulariae extract, 0.02%-0.05% of licorice root extract and 200 ml of arnebia root oil. The traditional Chinese medicine has the advantages of activating histocyte, activating the blood, promoting circulation of qi, dispelling wind, relieving pain, activating the collaterals, eliminating stagnation, repairing lateral sclerosis and restoring the normal function.

Description

A kind of Chinese medicine and preparation for the treatment of ALS disease
Technical field
The present invention relates to a kind of medicine and preparation for the treatment of amyotrophia funiculus lateralis disease.
Background technology is well-known, ALS (ALS) is also motor neuron disease (MND), a rear title Britain is conventional, and summer section (Charcot) disease is again by France, and the U.S. also claims Lu Jialeishi (LouGehrig) disease. China is conventionally mixed with motor neuron disease by ALS. It is after UM and lower motor neuron damage, and causes comprising the muscle unable and atrophy gradually of bulb (so-called bulb refers to this part muscle that oblongata is arranged exactly), four limbs, trunk, chest belly. Belong to the traditional Chinese medical science disease of withering. The treatment for the treatment of conventional Hormone, its long-term side-effects is large.
Summary of the invention
Useful effect of Chinese medicine of the present invention is: activation histocyte, and blood-activating and qi-promoting, wind-expelling pain-stopping, activating collaterals and eliminating stagnation, repair lateral sclerosis, recovers normal function. Often give diagnosis and treatment based on an overall analysis of the illness and the patient's condition according to different disease types clinically.
Technical problem to be solved by this invention is in order to overcome technical deficiency, and a kind of good effect, short treating period are provided, and remission rate is high, and cost is low, a kind of medicine and the preparation for the treatment of amyotrophia funiculus lateralis disease having no side effect.
For above-mentioned purpose, treat medicine and the preparation of amyotrophia funiculus lateralis disease, it is characterized in that its raw material medicines in portions by weight is as follows: Herba Lycopodii extract 0.02-0.05%, river bow extract 0.02-0.05%, panax japonicus extract 0.02-0.05%, daffodil seed extract 0.02-0.05%, red paeonia extract 0.02-0.05%, Folium Isatidis extract 0.02-0.05%, Angelica Dahurica extract 0.02-0.05%, spikemoss extract 0.2-0.5%, Radix Scrophulariae extract 0.02-0.05%, licorice 0.02-0.05%, Groomwell root oil 200ml.
Above drug extract, except Groomwell root oil, all adopts the finished medicines of current domestic mature technology. First Asian puccoon adds sesame oil slow fire extracts 30 minutes, filters, and extracts supernatant, to obtain final product. Then by after above drug extract porphyrize powder, merging adds Groomwell root oil 200ml and mixes, and vacuum decompression is dry, and being concentrated into relative density is the clear cream of 1.25 (60 DEG C), to obtain final product. Also can be made into the multiple formulations such as particle. The present invention allows to add auxiliary material in prescribed limit.
Herba Lycopodii extract lycopodium calvatum in Chinese medicine of the present invention is mainly containing alkaloids, terpene, phytosterol compounds. Anti-inflammatory, antipyretic, analgesic activity. Effect to central nervous system: 100% 0.5ml of lycopodium calvatum suspension mouse stomach, the length of one's sleep of energy significant prolongation yellow Jackets; Can obviously strengthen the stride that mouse causes cocainehydrochloride crooked, alter row, the toxic reaction such as go in ring, and to central stimulant unrestraint effects such as strychnines. Experimental silicosis is had to good curative effect. The effect of relaxing smooth muscle. River bow extract has pharmacological action: blood-activating and qi-promoting, wind-expelling pain-stopping. For irregular menstruation, through closing dysmenorrhoea ， wei lump in the abdomen stomachache, the shouting pain of the chest side of body, tumbling and swelling, headache, arthralgia due to wind-dampness. Panax japonicus extract is fat-soluble has anticoagulation, anti-inflammatory and antalgic, antifatigue, oxidation resistant pharmacologically active. Daffodil seed extract extracts from narcissus plant bulb, has effect clearing heat and detoxicating, mass dissipating and swelling eliminating, the treatment for mumps, carbuncle furuncle serious case of furuncle from the beginning of symptoms such as red and swollen heat pains. Red paeonia extract derives from the root of cohosh Chinese herbaceous peony paeonialactiflorapall. or river radix paeoniae rubrathe paeoniaveitchiilynch. There is invigorating blood circulation, suppress platelet aggregation. Folium Isatidis extract 1, staphylococcus aureus, alpha streptococcus, diplococcus meningitidis, streptococcus pneumonia, micrococcus catarrhalis, typhoid bacillus, Escherichia coli, Bacillus influenzae, corynebacterium diphtheriae and shigella dysenteriae are all had to certain inhibitory action, japanese encephalitis virus, mumps virus, influenza virus etc. are also had to inhibitory action. Kill leptospiral effect. Find that there is the effect of the enterobacteria O111B4 of Chinese People's Anti-Japanese Military and Political College endotoxin through In vitroandin vivotrial. To infectiousness, heating has obvious refrigeration function, and cooling is fast, and toxicity is little. To multiple proinflammatory agent, caused inflammatory reaction has obvious inhibitory action. Antivirus action: relevant different virus strain has inhibition or delays cytopathic effect to the infection of the upper respiratory tract. Apiolin is mainly completed by operations such as alcohol extracting, extraction, chromatography, crystallizations, is mainly completed by operations such as alcohol extracting, extraction, chromatography, crystallizations. Apiolin belongs to flavonoids. There is the carcinogenic activity that suppresses carcinogen; As the antiviral drugs for the treatment of HIV and other virus infections; The inhibitor of map kinase; Treat various inflammation; Antioxidant; Calm, calm the nerves; Step-down. Radix Scrophulariae extract warp: be slightly cold; Sweet, bitter, salty; Return lung, stomach, kidney channel. Function cures mainly: cool blood enriching yin, purging intense heat and detonicating. For consumption of YIN caused by febrile disease, hot eyes, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus. Angelica Dahurica extract has pain relieving effect; Spikemoss extract function with cure mainly: activating blood to promote menstruation. Be used for through closing dysmenorrhoea. { note of the ancient Chinese } lump in the abdomen lump in the abdomen, injury from falling down. Selaginella tamariscina charcoal removing blood stasis and hemostasis. Radix Scrophulariae extract function cures mainly: cool blood enriching yin, purging intense heat and detonicating. For consumption of YIN caused by febrile disease, hot eyes, pharyngalgia, scrofula, diphtheria, carbuncle ..... Above compatibility of drugs, bring out the best in each other.
The present invention follows the prescription principle of the traditional Chinese medical science, the use that is decocted in water for oral dose, and through clinical application for many years checking, total effective rate is 96.7%, and cure rate 83.8%, has no side effect.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1: a kind of medicine and preparation for the treatment of amyotrophia funiculus lateralis disease, is characterized in that its raw material medicines in portions by weight is as follows: Herba Lycopodii extract 0.02-0.05%, river bow extract 0.02-0.05%, panax japonicus extract 0.02-0.05%, daffodil seed extract 0.02-0.05%, red paeonia extract 0.02-0.05%, Folium Isatidis extract 0.02-0.05%, Angelica Dahurica extract 0.02-0.05%, spikemoss extract 0.2-0.5%, Radix Scrophulariae extract 0.02-0.05%, licorice 0.02-0.05%, Groomwell root oil 200ml. Vacuum decompression is dry, and being concentrated into relative density is the clear cream of 1.25 (60 DEG C), obtains 100 parts.
Embodiment 2: plant medicine and the preparation for the treatment of amyotrophia funiculus lateralis disease, it is characterized in that its raw material medicines in portions by weight is as follows: Herba Lycopodii extract 0.02-0.05%, river bow extract 0.02-0.05%, panax japonicus extract 0.02-0.05%, daffodil seed extract 0.02-0.05%, red paeonia extract 0.02-0.05%, Folium Isatidis extract 0.02-0.05%, Angelica Dahurica extract 0.02-0.05%, spikemoss extract 0.2-0.5%, Radix Scrophulariae extract 0.02-0.05%, licorice 0.02-0.05%, Groomwell root oil 200ml. Vacuum decompression is dry, be concentrated into relative density and be 1.25 (60 DEG C) clear cream, add appropriate dextrin drying, be ground into particle. Obtain particle and divide 100 bags.
Clinical efficacy is summed up:
One, physical data: we are extensive in clinical practice for many years, treatment 62 routine patients, wherein male 35 examples, female's 37 examples, the age is at 51～72 years old, average 59 years old. Curative effect is frequently good.
Two, diagnostic criteria: early symptom is slight, easy and other diseases is obscured. Patient may just feel to have some symptoms such as some are unable, meat is jumped, easy fatigue, and progress is whole-body muscle atrophy and dysphagia gradually. Finally produce respiratory failure. Be broadly divided into amphitypy according to clinical symptoms: 1) limbs disease type: first symptom is limb muscle progressive atrophoderma, unable, finally just produce respiratory failure. 2) oblongata disease type: quadruped locomotion not bad in, just occur swallowing, difficulty speaking, progress is respiratory failure soon. 3. check: early diagnosis ALS, except Neurological Clinics inspection, also need to do electromyogram, MNCV detection, the inspection of serum distinct antibodies, waist and wear examination of cerebrospinal fluid, imaging examination, even muscle biopsy.
Three, method of administration: each 1 bag particle or clear cream 10g, take orally every day for 2 times.
Four, curative effect judging standard
Cure: clinical symptoms disappear completely.
Take a turn for the better: clinical symptom relief.
Invalid: clinical symptoms are unchanged or increase the weight of.
Five, result for the treatment of: the present invention is for many years in clinical practice, and treatment 62 routine patients, cure 52 examples 83.8%, and 9 examples that take a turn for the better, are 12.9%; Invalid 1 example. Total effective rate is 96.7%, cure rate 83.8%.
Six, model case
1, king XX, man, 52 years old, in September, 2012 was medical. Main suit just felt to have some symptoms such as some are unable, meat is jumped, easy fatigue before one week, progress is whole-body muscle atrophy, dysphagia gradually. Patient requires to take 30 doses, Chinese medicine of the present invention, and clinical symptoms disappear completely, after half a year, do not follow up a case by regular visits to and do not recur.
2, open XX, female, 64 years old, in June, 2013 was medical, and main suit feels some symptoms such as meat is jumped, easy fatigue, and progress is whole-body muscle atrophy gradually. Medical technologies check: electromyogram, MNCV detect and meet this disease. Patient requires to take 30 doses, Chinese medicine of the present invention, and clinical symptoms disappear completely, after half a year, do not follow up a case by regular visits to and do not recur.
3, Wu X, female, 57 years old, in July, 2014 was medical. Main suit felt to have that some are unable before 2 days, meat is jumped, easy some symptoms such as tired, gradually made progress leg muscle atrophy. Patient requires to take 20 doses, Chinese medicine of the present invention, and clinical symptoms disappear completely, after half a year, do not follow up a case by regular visits to and do not recur.

Claims (2)

1. treat a Chinese medicine for the sclerosis of amyotrophia funiculus lateralis, the raw material medicines in portions by weight that it is characterized in that it asUnder: a kind of medicine and preparation for the treatment of amyotrophia funiculus lateralis disease, is characterized in that its raw material medicines in portions by weight is as follows:Herba Lycopodii extract 0.02-0.05%, river bow extract 0.02-0.05%, panax japonicus extract 0.02-0.05%,Daffodil seed extract 0.02-0.05%, red paeonia extract 0.02-0.05%, Folium Isatidis extract0.02-0.05%, Angelica Dahurica extract 0.02-0.05%, spikemoss extract 0.2-0.5%, Radix Scrophulariae extract0.02-0.05%, licorice 0.02-0.05%, Groomwell root oil 200ml.
2. the preparation technology who treats the sclerosis Chinese medicine of amyotrophia funiculus lateralis according to one kind of claim 1, is characterized in that
First Asian puccoon is added to sesame oil slow fire and extract 30 minutes, filter, extract supernatant, to obtain final product, then above medicine is carriedGet after thing porphyrize powder, merging adds Groomwell root oil 200ml and mixes, and vacuum decompression is dry, and being concentrated into relative density is 1.25 (60 DEG C)Clear cream, to obtain final product. Also can be made into the multiple formulations such as particle.
CN201510908931.6A 2015-12-06 2015-12-06 Traditional Chinese medicine for treating amyotrophic lateral sclerosis and preparation Pending CN105582186A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019159203A1 (en) * 2018-02-16 2019-08-22 PALUMBO, Rosario A method for reactivating the sensation of the taste of food in patients suffering from als or dysphagia

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019159203A1 (en) * 2018-02-16 2019-08-22 PALUMBO, Rosario A method for reactivating the sensation of the taste of food in patients suffering from als or dysphagia

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Application publication date: 20160518