CN103505562B - For treating the Chinese medicine of keratitis - Google Patents

Abstract

The present invention relates to field of traditional Chinese medicine formula, a kind of Chinese medicine for treating keratitis, it is characterized in that, raw material composition is by weight percentage, Cortex Fraxini 8～10%, Semen Cassiae 8～10%, Radix Gentianae 4～7%, Cortex Lycii 7～10%, Spica Prunellae 8～10%, Fructus Tribuli 4～7%, Flos Chrysanthemi 4～6%, Ramulus Uncariae Cum Uncis 4～7%, Carapax Trionycis 11～15%, Herba Artemisiae Annuae 4～7%, Radix Paeoniae Rubra 4～6%, Rhizoma Et Radix Notopterygii 3～5%, Rhizoma Atractylodis 5～6%, the Rhizoma Atractylodis Macrocephalae 4～6%, Periostracum Serpentis 1～2%, Cornu Saigae Tataricae 0.4～1%, first Periostracum Serpentis, Cornu Saigae Tataricae is individually dried, grind and be ground into fine powder, cross 120 mesh sieves, individually wrap, again remaining 14 taste crude drug are soaked, then filtrate of removing slag to obtain is decocted, finally by Periostracum Serpentis, Cornu Saigae Tataricae fine powder joins in filtrate.Low cost of the present invention, treatment keratitis curative effect is high, has no side effect, and has liver heat removing and eyesight improving, eliminating pathogen in the liver gallbladder fire, wind dispelling of invigorating blood circulation, dissipates the effects such as blood removing toxic substances, hard masses softening and resolving, and the keratitis causing the causes of disease such as the source of infection, endogenous and Local immunotherapy is the most effective.

Description

For treating the Chinese medicine of keratitis

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, a kind of Chinese medicine for treating keratitis.

Background technology

It is known that cornea defence capability weakens, extraneous or endogenous paathogenic factor all may cause cornea Tissue inflammation occurs.Commonly encountered diseases is because having the source of infection, endogenous and Local immunotherapy.Infected keratitis is extremely The present is still global common diseases causing blindness, and about 20% blind person is blind because of ocular infection.Main pathogen Microorganism is antibacterial, fungus, virus, and the report about Acanthamoeba keratitis the most constantly increases in recent years Adding, other also have clothing originality, tubercule bacillus and treponema pallidum etc.；The main autoimmunity of endogenous is complete Body disease such as rheumatoid arthritis, vitamin A deficiency cause bitot's patches or keratomalacia；Adjacent tissue Inflammation can involve cornea, such as conjunctivitis, scleritis, iridocyclitis etc..Though the cause of disease of keratitis So differ, but its pathological change process generally have common feature, can be divided into infiltration stage, ulcerative stage, Ulcer paracmasis and 4 stages of healing stage.Modal symptom is ophthalmalgia, photophobia, shed tears, eyelid convulsion Contractions etc., sustainable exist up to inflammatory resolution.Keratitis generally entails visual deterioration in various degree, if The centrally located smooth school district of pathological changes, then visual deterioration becomes apparent from.Suppurative keratitis is bad except occurring that cornea suppurates Outside dead focus, its infiltration stove surface is also with the purulent secretion of different symptoms.The Therapeutic Principle of keratitis For actively controlling to infect, reduce inflammation reaction, promotes ulcer healing, reduces cicatrization.But lack at present Weary efficient, the ideal medicament of low toxicity, broad-spectrum antiseptic.Preventing from recurring also is the emphasis for the treatment of, but at present the most still Without specific medicament.

Summary of the invention

The technical problem to be solved is to overcome above-mentioned the deficiencies in the prior art, it is provided that a kind of Low cost, treatment keratitis curative effect is high, has no side effect, and has liver heat removing and eyesight improving, eliminating pathogen in the liver gallbladder fire, invigorates blood circulation The effects such as wind dispelling, scattered blood removing toxic substances, hard masses softening and resolving, to causes of disease such as the source of infection, endogenous and Local immunotherapy The keratitis caused is the most effective.

The present invention solves above-mentioned technical problem and the technical scheme is that a kind of for treating in keratitis Medicine, is characterized in that, raw material composition is by weight percentage: Cortex Fraxini 8～10%, Semen Cassiae 8～10%, Radix Gentianae 4～7%, Cortex Lycii 7～10%, Spica Prunellae 8～10%, Fructus Tribuli 4～7%, Flos Chrysanthemi 4～6%, Ramulus Uncariae Cum Uncis 4～7%, Carapax Trionycis 11～15%, Herba Artemisiae Annuae 4～7%, Radix Paeoniae Rubra 4～6%, Rhizoma Et Radix Notopterygii 3～5%, Rhizoma Atractylodis 5～ 6%, the Rhizoma Atractylodis Macrocephalae 4～6%, Periostracum Serpentis 1～2%, Cornu Saigae Tataricae 0.4～1%, first Periostracum Serpentis, Cornu Saigae Tataricae are individually dried, Grind and be ground into fine powder, cross 120 mesh sieves, individually wrap, more remaining 14 taste crude drug are soaked, Then decoct filtrate of removing slag to obtain, finally Periostracum Serpentis, Cornu Saigae Tataricae fine powder are joined in filtrate.

Low cost of the present invention, treatment keratitis curative effect is high, has no side effect, has liver heat removing and eyesight improving, eliminating pathogen in the liver The effect such as gallbladder fire, wind dispelling of invigorating blood circulation, scattered blood removing toxic substances, hard masses softening and resolving, to the source of infection, endogenous and local The keratitis that the cause of disease causes such as spread the most effective.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described:

Embodiment one:

Use Cortex Fraxini, Semen Cassiae, Radix Gentianae, Cortex Lycii, Spica Prunellae, Fructus Tribuli, Flos Chrysanthemi, Ramulus Uncariae Cum Uncis, Trionyx sinensis Wiegmann First, Herba Artemisiae Annuae, Radix Paeoniae Rubra, Rhizoma Et Radix Notopterygii, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Periostracum Serpentis, Cornu Saigae Tataricae are that raw material is prepared from.Its group Point (weight %) every pair is Cortex Fraxini 9.5, Semen Cassiae 9.2, Radix Gentianae 6.1, Cortex Lycii 9.2, Spica Prunellae 9.1, Fructus Tribuli 5.6, Flos Chrysanthemi 5.6, Ramulus Uncariae Cum Uncis 5.5, Carapax Trionycis 13.4, Herba Artemisiae Annuae 5.7, Radix Paeoniae Rubra 5.1, Rhizoma Et Radix Notopterygii 4.1, Rhizoma Atractylodis 5.1, the Rhizoma Atractylodis Macrocephalae 4.8, Periostracum Serpentis 1.6, Cornu Saigae Tataricae 0.4.Take above-mentioned 16 taste Chinese herbal medicine gross weights Amount is 169 grams.First Periostracum Serpentis, Cornu Saigae Tataricae are individually dried, grind and be ground into fine powder, cross 120 mesh sieves, single Solely wrap, to post labelling standby.Remaining 14 taste crude drug are added water to 900～1100ml, soak 4～ 6 hours, boil slow fire with high heat and decoct to 40～60 minutes, filtrate 150～about 170ml of removing slag to obtain, Medicinal residues add water about 250ml, decoct 30 minutes, filtrate 50～about 60ml of removing slag to obtain, there are 200～ About 230ml medicine juice, loads in sterile glass vials, adds Periostracum Serpentis, Cornu Saigae Tataricae powder shakes up, the most prepared For treating the Chinese medicine of keratitis, closed bottle cap is standby.Every day 1 dose point is administered orally for 2 times, each (medicine) being taken before meal 100～about 115ml medicine juice, leave and take 5～10ml medicine juice every time before (medicine) being taken before meal, dip medicine juice with cotton swab and wipe Wash eye, every day 2 times.Treat 4 weeks and carry out therapeutic evaluation.

Principal agent Cortex Fraxini bacteriostatic test of the present invention: Fraxinus americana Lvarjuglandifolia Rehd bark decoct is to shigella flexneri, typhoid fever bar Bacterium, Nai Shi coccus, Diplococcus pneumoniae, alpha streptococcus all have stronger inhibitory action.One-tenth in Cortex Fraxini Eaculin granuloma experimental for rat and edema is divided all to have inhibitory action.Nature and flavor are bitter, puckery, cold, Return liver, gallbladder, large intestine channel, there is heat clearing and damp drying, astringent therapy dysentery relieving, leukorrhagia stopping, improving eyesight effect.For conjunctival congestion Swell and ache, mesh gives birth to nebula film, damp-heat dysentery, leucorrhea with red and white discharge.Semen Cassiae bacteriostatic test: the alcohol extract of Semen Cassiae To staphylococcus, diphtheria corynebacterium, bacillus megaterium, Bacillus typhi, Salmonella paratyphi, B-mode secondary wound Cold bacillus and escherichia coli etc. all have bacteriostasis.Semen Cassiae water logging agent is equal to multiple pathogenic dermatophytes Having inhibitory action, nature and flavor are sweet, bitter, salty, be slightly cold, and return liver, large intestine channel.There is clearing away heat to improve acuity of vision, intestine moistening Relieving constipation effect, for the puckery pain of conjunctival congestion, acute ocular conjunctivitis, corneal ulcer, glaucoma, the many tear of photophobia, Headache dizziness, poor vision, constipation.Radix Gentianae bacteriostatic test: Radix Gentianae infusion is the most right The Bacteria skin infections such as Gypsum Fibrosum sample hair moss bacterium, star nocardia all have inhibitory action in various degree.Nature and flavor Bitter, cold, return liver, gallbladder meridian.There is heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire effect, for liver-fire conjunctival congestion, tinnitus Deafness, hypochondriac pain bitter taste, jaundice due to damp-heat, eczema pruritus etc..Cortex Lycii is to staphylococcus aureus, typhoid fever Bacillus, paratyphoid bacillus A and shigella flexneri etc. all have stronger inhibitory action.Nature and flavor are sweet, cold, Return lung, liver, kidney channel.Have pure blood except steam, lung heat clearing pathogenic fire reducing effect, for deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, Cough due to lung-heat, spitting of blood, epistaxis, interior-heat are quenched one's thirst.Spica Prunellae nature and flavor are pungent, bitter, cold, return liver, gallbladder meridian. There is purging liver-fire, improving eyesight, mass dissipating and swelling eliminating effect, for conjunctival congestion and swelling pain, mesh pearl nyctalgia, headache dizziness, Numbness scrofula, goiter, acute mastitis etc..Fructus Tribuli nature and flavor are pungent, bitter, tepor, slightly poisonous, return Liver Channel.There is suppressing the hyperactive liver Resolving depression, promoting blood circulation by removing wind, improving eyesight, itching-relieving efficacies, the dizziness that is used for having a headache, distending pain in the chest and hypochondrium, cataract, Rubella pruritus etc..Flos Chrysanthemi nature and flavor are sweet, bitter, be slightly cold, and return lung, Liver Channel, have scattered wind heat clearing away, suppressing the hyperactive liver bright Mesh, heat-clearing toxin-expelling functions, carbuncle sore dim-sighted for anemopyretic cold, headache dizziness, conjunctival congestion and swelling pain, eyes Toxic swelling.Ramulus Uncariae Cum Uncis nature and flavor are sweet, pure, return liver, pericardium channel, have dispelling wind and relieving convulsion, heat clearing away suppressing the hyperactive liver effect, use In liver-wind stirring up internally, infantile convulsion tic, hyperpyrexia convulsion, headache dizziness etc..Carapax Trionycis nature and flavor are salty, be slightly cold, return liver, Kidney channel.Have nourishing YIN for suppressing the hyperactive YANG, bring down a fever except steaming, clear hard heat radiation function, for fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, Hyperactivity of YANG due to deficiency of YIN, have a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency etc..Herba Artemisiae Annuae nature and flavor bitter, acrid, cold, return liver, gallbladder meridian.Tool Have clearind deficient heat, except hectic fever due to YIN-deficiency, solve summer-heat, cut disease, jaundice eliminating effect, for pathogenic warmth impairment of YIN, night fever abating at dawn, Fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, pathogenic summer-heat heating etc..Radix Paeoniae Rubra nature and flavor are bitter, be slightly cold, and return Liver Channel.There is heat clearing away Removing heat from blood, eliminating stasis to stop pain effect, enter nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, liver for heat Strongly fragrant hypochondriac pain etc..Rhizoma Et Radix Notopterygii nature and flavor acrid, bitter, warm, returns bladder, kidney channel.Have relieving exterior syndrome and dispelling cold, expelling wind and removing dampness, Analgesic efficacy, for anemofrigid cold, headache stiffness of the nape, rheumatic arthralgia, aching pain in shoulder and back.Rhizoma Atractylodis nature and flavor are pungent, Bitter, warm, return spleen, stomach, Liver Channel.There is drying damp and strengthening spleen, expelling wind and cold, improving eyesight effect.For dampness Middle Jiao, Guang distention and fullness in the abdomen, have loose bowels, edema, nyctalopia, eyes dusk puckery etc..Rhizoma Atractylodis Macrocephalae nature and flavor are bitter, sweet, warm, Return spleen, stomach warp.There is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect, for insufficiency of the spleen lack of appetite, Abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Periostracum Serpentis nature and flavor are salty, sweet, flat, return liver Warp.Have dispel the wind, calm the frightened, nebula removing, detoxicating functions.Swollen for infantile convulsion, cataracta, sore throat, furuncle, Skin pruritus etc..Cornu Saigae Tataricae nature and flavor are salty-cold, return liver, heart channel.There is suppressing the hyperactive liver to relieve the wind syndrome, liver heat removing and eyesight improving, dissipate Blood detoxicating functions, for cataract, headache dizziness, maculae caused by violent heat pathogen, hyperpyrexia convulsion etc..16 taste medium-height grass The ingenious prescription of medicine, scientific compatibility, mutual reinforcement between, make to play coordinative role mutually, drug effect can be improved；Mutual restraint between two drugs, The mutual-detoxication can be mitigated or eliminated toxic and side effects, the mutually coordinated effect of medicine, plays the specially good effect of keratitis altogether.

The each raw material of the present invention also can the embodiment that mixes of ratio (percentage by weight) listed by according to the form below realize, It decocts program, Therapeutic Method and embodiment 1, and its content is as shown in the table.

Below in conjunction with my institute, the clinical trial that i.e. central hospital of In Shandong Weihai Wendeng City is carried out is to the present invention Make further, describe in detail:

1. case selection: select carry out my institute diagnosis and treatment patient 64 in December, 2012 in June, 2006 Example, inquires eye morbidity history, disease time, cardinal symptom etc. the most in detail to each case.Conventional inspection Look into eye conditions, optimal tender positive vision, corneal sensation and fluorescent staining examination with slitlamp microscope, really Examine and amount to 64 examples for keratitis patients.Wherein cause 36 examples because of the source of infection；Endogenous causes 12 examples； Local immunotherapy causes 16 examples.Man's 39 examples, female 25 example.Age 17～66 years old.

2. the diagnostic criteria: " Chinese medical disease that tcm diagnosis standard is promulgated with reference to State Administration of Traditional Chinese Medicine Standardization of diagnosis and curative effect ".

3. Therapeutic Method: every day 1 dose point is administered orally for 2 times, each (medicine) being taken before meal 100～about 115ml medicine Juice, leaves and takes 5～10ml medicine juice every time before (medicine) being taken before meal, dip medicine juice with cotton swab and clean eye, every day 2 times. Treat 4 weeks and carry out therapeutic evaluation.

4. observation index and therapeutic evaluation: observation eye's symptom (sensation of dryness, foreign body sensation) weekly, Sign (non-principal feature includes conjunctival congestion, corneal ulcer, edema etc.), fluorescent staining observes cornea Epithelium point-like defect healing state.Medication carries out therapeutic evaluation in 4 weeks.

Recovery from illness: the irritation such as sensation of dryness, foreign body sensation disappears, ulcer surface heals, clinical symptoms, sign Disappearing, fluorescent staining transfers feminine gender to；

Effective: the irritation such as sensation of dryness, foreign body sensation disappears substantially, slightly irritation, clinical condition Shape, sign are clearly better, fluorescent staining +++ →+or ++ → few；

Take a turn for the better: sensation of dryness, foreign body sensation irritation and clinical symptoms, sign alleviate, fluorescent staining +++ → ++ or ++ →+；

Invalid: medication 4 weeks, clinical observation suffer from eye symptom, sign without change, fluorescent staining is without substantially Change.

Recovery from illness adds effective for total effective rate, takes a turn for the better, invalid for inefficiency.

Therapeutic outcome: use the present invention 64 example patient, through carrying out treatment effectiveness evaluation with the standard of curative effect evaluation, Fully recovering 23 examples, effective 35 examples, take a turn for the better 4 examples, invalid 2 examples.Total effective rate is 90.6%, inefficiency It is 9.4%.

Claims (1)

1. for treating a Chinese medicine composition for keratitis, it is characterized in that: raw material forms with weight percent Ratio is calculated as, Cortex Fraxini 8～10%, Semen Cassiae 8～10%, Radix Gentianae 4～7%, and Cortex Lycii 7～10%, the summer is withered Grass 8～10%, Fructus Tribuli 4～7%, Flos Chrysanthemi 4～6%, Ramulus Uncariae Cum Uncis 4～7%, Carapax Trionycis 11～15%, Herba Artemisiae Annuae 4～ 7%, Radix Paeoniae Rubra 4～6%, Rhizoma Et Radix Notopterygii 3～5%, Rhizoma Atractylodis 5～6%, the Rhizoma Atractylodis Macrocephalae 4～6%, Periostracum Serpentis 1～2%, Saigae Tataricae Angle 0.4～1%, first individually dries Periostracum Serpentis, Cornu Saigae Tataricae, grinds and be ground into fine powder, crosses 120 mesh sieves, single Solely wrap, more remaining 14 taste crude drug are soaked, then decoct filtrate of removing slag to obtain, finally by Serpentis Slough off, Cornu Saigae Tataricae fine powder joins in filtrate.