CN105722979A - 肝癌相关的基因特异性siRNA、包含所述siRNA的双链寡RNA分子和包含它们的用于预防或治疗癌症的组合物 - Google Patents
肝癌相关的基因特异性siRNA、包含所述siRNA的双链寡RNA分子和包含它们的用于预防或治疗癌症的组合物 Download PDFInfo
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- CN105722979A CN105722979A CN201480049435.3A CN201480049435A CN105722979A CN 105722979 A CN105722979 A CN 105722979A CN 201480049435 A CN201480049435 A CN 201480049435A CN 105722979 A CN105722979 A CN 105722979A
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/351—Conjugate
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
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- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2013-0080580 | 2013-07-09 | ||
| KR1020130080580A KR20150006743A (ko) | 2013-07-09 | 2013-07-09 | 간암 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 암 예방 또는 치료용 조성물 |
| PCT/KR2014/006146 WO2015005670A1 (en) | 2013-07-09 | 2014-07-09 | LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105722979A true CN105722979A (zh) | 2016-06-29 |
Family
ID=52280272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480049435.3A Pending CN105722979A (zh) | 2013-07-09 | 2014-07-09 | 肝癌相关的基因特异性siRNA、包含所述siRNA的双链寡RNA分子和包含它们的用于预防或治疗癌症的组合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20160145624A1 (enExample) |
| EP (1) | EP3019612A4 (enExample) |
| JP (1) | JP2016523557A (enExample) |
| KR (1) | KR20150006743A (enExample) |
| CN (1) | CN105722979A (enExample) |
| WO (1) | WO2015005670A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111132682A (zh) * | 2017-07-28 | 2020-05-08 | 雷莫内克斯生物制药有限公司 | 用于预防或治疗肝癌的药物组合物 |
| CN113271980A (zh) * | 2018-11-28 | 2021-08-17 | 柏业公司 | 包含雄激素受体特异性序列的双链寡核苷酸构建体以及包含其的用于预防脱发和促进头发生长的组合物 |
| CN113308541A (zh) * | 2021-03-29 | 2021-08-27 | 广州医科大学 | c-Myc和Chd1l在肿瘤治疗和诊断中的应用 |
| CN115282283A (zh) * | 2022-06-21 | 2022-11-04 | 浙江浥眸生物科技有限公司 | 一种小分子药物-寡核苷酸偶联物及其应用 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101861738B1 (ko) | 2016-08-24 | 2018-05-29 | (주)바이오니아 | 마이크로 rna를 포함하는 이중나선 올리고 rna 구조체 |
| EP3917540A1 (en) | 2019-01-31 | 2021-12-08 | Ionis Pharmaceuticals, Inc. | Modulators of yap1 expression |
| KR20210120581A (ko) | 2020-03-27 | 2021-10-07 | 연세대학교 산학협력단 | 저산소성 대장암의 예방 또는 치료용 조성물 |
| WO2025024334A1 (en) | 2023-07-21 | 2025-01-30 | Marrow Therapeutics, Inc. | Hematopoietic cell targeting conjugates and related methods |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1560931B1 (en) * | 2002-11-14 | 2011-07-27 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| WO2007044468A2 (en) * | 2005-10-05 | 2007-04-19 | The Cbr Institute For Biomedical Research, Inc. | Method to treat flavivirus infection with sirna |
| JP2008295327A (ja) * | 2007-05-30 | 2008-12-11 | Fujifilm Corp | 口腔扁平上皮癌の検出方法、及び抑制方法 |
| KR101224828B1 (ko) * | 2009-05-14 | 2013-01-22 | (주)바이오니아 | siRNA 접합체 및 그 제조방법 |
| WO2011000106A1 (en) * | 2009-07-01 | 2011-01-06 | Protiva Biotherapeutics, Inc. | Improved cationic lipids and methods for the delivery of therapeutic agents |
| US8871509B2 (en) * | 2009-11-06 | 2014-10-28 | Chung-Ang University-Academy Corporation Foundation | Nanoparticle-based gene delivery systems |
| PL2736887T3 (pl) * | 2011-07-29 | 2018-03-30 | Karyopharm Therapeutics, Inc. | Modulatory transportu jądrowego zawierające ugrupowanie hydrazydu i ich zastosowania |
-
2013
- 2013-07-09 KR KR1020130080580A patent/KR20150006743A/ko not_active Withdrawn
-
2014
- 2014-07-09 CN CN201480049435.3A patent/CN105722979A/zh active Pending
- 2014-07-09 WO PCT/KR2014/006146 patent/WO2015005670A1/en not_active Ceased
- 2014-07-09 US US14/903,043 patent/US20160145624A1/en not_active Abandoned
- 2014-07-09 JP JP2016525280A patent/JP2016523557A/ja not_active Withdrawn
- 2014-07-09 EP EP14823194.7A patent/EP3019612A4/en not_active Withdrawn
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111132682A (zh) * | 2017-07-28 | 2020-05-08 | 雷莫内克斯生物制药有限公司 | 用于预防或治疗肝癌的药物组合物 |
| CN111132682B (zh) * | 2017-07-28 | 2024-04-26 | 雷莫内克斯生物制药有限公司 | 用于预防或治疗肝癌的药物组合物 |
| US12076336B2 (en) | 2017-07-28 | 2024-09-03 | Lemonex Inc. | Pharmaceutical composition for preventing or treating liver cancer |
| CN113271980A (zh) * | 2018-11-28 | 2021-08-17 | 柏业公司 | 包含雄激素受体特异性序列的双链寡核苷酸构建体以及包含其的用于预防脱发和促进头发生长的组合物 |
| CN113271980B (zh) * | 2018-11-28 | 2024-02-02 | 柏业公司 | 包含雄激素受体特异性序列的双链寡核苷酸构建体以及包含其的用于预防脱发和促进头发生长的组合物 |
| CN113308541A (zh) * | 2021-03-29 | 2021-08-27 | 广州医科大学 | c-Myc和Chd1l在肿瘤治疗和诊断中的应用 |
| CN115282283A (zh) * | 2022-06-21 | 2022-11-04 | 浙江浥眸生物科技有限公司 | 一种小分子药物-寡核苷酸偶联物及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3019612A1 (en) | 2016-05-18 |
| WO2015005670A1 (en) | 2015-01-15 |
| KR20150006743A (ko) | 2015-01-19 |
| EP3019612A4 (en) | 2017-06-28 |
| JP2016523557A (ja) | 2016-08-12 |
| US20160145624A1 (en) | 2016-05-26 |
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Application publication date: 20160629 |