JP2016523557A - 肝臓癌関連遺伝子特異的ｓｉＲＮＡ、そのようなｓｉＲＮＡを含む二重らせんオリゴＲＮＡ構造体及びこれを含む癌予防または治療用組成物 - Google Patents

肝臓癌関連遺伝子特異的ｓｉＲＮＡ、そのようなｓｉＲＮＡを含む二重らせんオリゴＲＮＡ構造体及びこれを含む癌予防または治療用組成物 Download PDF

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JP2016523557A
JP2016523557A JP2016525280A JP2016525280A JP2016523557A JP 2016523557 A JP2016523557 A JP 2016523557A JP 2016525280 A JP2016525280 A JP 2016525280A JP 2016525280 A JP2016525280 A JP 2016525280A JP 2016523557 A JP2016523557 A JP 2016523557A
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sirna
cancer
oligo rna
rna structure
double helix
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JP2016525280A
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JP2016523557A5 (enExample
Inventor
ジェウク チェ
ジェウク チェ
ピョンオ ユン
ピョンオ ユン
ハンナ キム
ハンナ キム
ハンオ パク
ハンオ パク
ボラム ハン
ボラム ハン
ヨンホ コ
ヨンホ コ
ギウン チョイ
ギウン チョイ
ジェウン キム
ジェウン キム
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Bioneer Corp
Sanofi Aventis Korea Co Ltd
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Bioneer Corp
Sanofi Aventis Korea Co Ltd
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Publication of JP2016523557A publication Critical patent/JP2016523557A/ja
Publication of JP2016523557A5 publication Critical patent/JP2016523557A5/ja
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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  • General Chemical & Material Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016525280A 2013-07-09 2014-07-09 肝臓癌関連遺伝子特異的ｓｉＲＮＡ、そのようなｓｉＲＮＡを含む二重らせんオリゴＲＮＡ構造体及びこれを含む癌予防または治療用組成物 Withdrawn JP2016523557A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2013-0080580 2013-07-09
KR1020130080580A KR20150006743A (ko) 2013-07-09 2013-07-09 간암 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 암 예방 또는 치료용 조성물
PCT/KR2014/006146 WO2015005670A1 (en) 2013-07-09 2014-07-09 LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME

Publications (2)

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JP2016523557A true JP2016523557A (ja) 2016-08-12
JP2016523557A5 JP2016523557A5 (enExample) 2016-11-04

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JP2016525280A Withdrawn JP2016523557A (ja) 2013-07-09 2014-07-09 肝臓癌関連遺伝子特異的ｓｉＲＮＡ、そのようなｓｉＲＮＡを含む二重らせんオリゴＲＮＡ構造体及びこれを含む癌予防または治療用組成物

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Country Link
US (1) US20160145624A1 (enExample)
EP (1) EP3019612A4 (enExample)
JP (1) JP2016523557A (enExample)
KR (1) KR20150006743A (enExample)
CN (1) CN105722979A (enExample)
WO (1) WO2015005670A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020534251A (ja) * 2017-07-28 2020-11-26 レモネックス インコーポレイテッドＬｅｍｏｎｅｘ Ｉｎｃ． 肝癌の予防または治療用の薬学的組成物

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101861738B1 (ko) 2016-08-24 2018-05-29 (주)바이오니아 마이크로 rna를 포함하는 이중나선 올리고 rna 구조체
KR102473989B1 (ko) * 2018-11-28 2022-12-07 (주)바이오니아 안드로젠 수용체 특이적 서열을 포함하는 이중나선 올리고뉴클레오티드 구조체, 및 이를 포함하는 탈모 예방 및 발모용 조성물
EP3917540A1 (en) 2019-01-31 2021-12-08 Ionis Pharmaceuticals, Inc. Modulators of yap1 expression
KR20210120581A (ko) 2020-03-27 2021-10-07 연세대학교 산학협력단 저산소성 대장암의 예방 또는 치료용 조성물
CN113308541A (zh) * 2021-03-29 2021-08-27 广州医科大学 c-Myc和Chd1l在肿瘤治疗和诊断中的应用
CN115282283B (zh) * 2022-06-21 2024-11-29 上海交通大学 一种小分子药物-寡核苷酸偶联物及其应用
WO2025024334A1 (en) 2023-07-21 2025-01-30 Marrow Therapeutics, Inc. Hematopoietic cell targeting conjugates and related methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1560931B1 (en) * 2002-11-14 2011-07-27 Dharmacon, Inc. Functional and hyperfunctional sirna
WO2007044468A2 (en) * 2005-10-05 2007-04-19 The Cbr Institute For Biomedical Research, Inc. Method to treat flavivirus infection with sirna
JP2008295327A (ja) * 2007-05-30 2008-12-11 Fujifilm Corp 口腔扁平上皮癌の検出方法、及び抑制方法
KR101224828B1 (ko) * 2009-05-14 2013-01-22 (주)바이오니아 ｓｉＲＮＡ 접합체 및 그 제조방법
WO2011000106A1 (en) * 2009-07-01 2011-01-06 Protiva Biotherapeutics, Inc. Improved cationic lipids and methods for the delivery of therapeutic agents
US8871509B2 (en) * 2009-11-06 2014-10-28 Chung-Ang University-Academy Corporation Foundation Nanoparticle-based gene delivery systems
PL2736887T3 (pl) * 2011-07-29 2018-03-30 Karyopharm Therapeutics, Inc. Modulatory transportu jądrowego zawierające ugrupowanie hydrazydu i ich zastosowania

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020534251A (ja) * 2017-07-28 2020-11-26 レモネックス インコーポレイテッドＬｅｍｏｎｅｘ Ｉｎｃ． 肝癌の予防または治療用の薬学的組成物

Also Published As

Publication number Publication date
CN105722979A (zh) 2016-06-29
EP3019612A1 (en) 2016-05-18
WO2015005670A1 (en) 2015-01-15
KR20150006743A (ko) 2015-01-19
EP3019612A4 (en) 2017-06-28
US20160145624A1 (en) 2016-05-26

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