CN105709137A - 一种治疗慢性盆腔炎的中药制剂 - Google Patents
一种治疗慢性盆腔炎的中药制剂 Download PDFInfo
- Publication number
- CN105709137A CN105709137A CN201610210209.XA CN201610210209A CN105709137A CN 105709137 A CN105709137 A CN 105709137A CN 201610210209 A CN201610210209 A CN 201610210209A CN 105709137 A CN105709137 A CN 105709137A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- radix
- inflammatory disease
- medicine preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 53
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 title claims abstract description 23
- 230000001684 chronic effect Effects 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 241000746375 Andrographis Species 0.000 claims abstract description 14
- 239000008589 Cortex Fraxini Substances 0.000 claims abstract description 14
- 239000002775 capsule Substances 0.000 claims abstract description 9
- 241000628997 Flos Species 0.000 claims description 11
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 11
- 241000180649 Panax notoginseng Species 0.000 claims description 11
- 239000009806 pulsatillae Substances 0.000 claims description 11
- 229920002472 Starch Polymers 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 239000008107 starch Substances 0.000 claims description 7
- 235000019698 starch Nutrition 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 6
- 230000002829 reductive effect Effects 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 3
- 239000000284 extract Substances 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 238000003809 water extraction Methods 0.000 claims description 3
- RHAXKFFKGZJUOE-UHFFFAOYSA-N 7-acetyl-6-ethyl-3,5,8-trihydroxy-9,10-dioxoanthracene-1,2-dicarboxylic acid Chemical compound O=C1C2=CC(O)=C(C(O)=O)C(C(O)=O)=C2C(=O)C2=C1C(O)=C(CC)C(C(C)=O)=C2O RHAXKFFKGZJUOE-UHFFFAOYSA-N 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 38
- 229940079593 drug Drugs 0.000 abstract description 12
- 241001528553 Malus asiatica Species 0.000 abstract description 5
- 235000008216 herbs Nutrition 0.000 abstract description 5
- 230000008901 benefit Effects 0.000 abstract description 4
- 238000002474 experimental method Methods 0.000 abstract description 4
- 241000205585 Aquilegia canadensis Species 0.000 abstract description 2
- 241000721047 Danaus plexippus Species 0.000 abstract description 2
- 241000244987 Daiswa polyphylla Species 0.000 abstract 2
- 241000123725 Sophora tonkinensis Species 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 229940088710 antibiotic agent Drugs 0.000 abstract 2
- 241000132012 Atractylodes Species 0.000 abstract 1
- 241001355283 Cayratia Species 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 244000236658 Paeonia lactiflora Species 0.000 abstract 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 abstract 1
- 241000206469 Pulsatilla Species 0.000 abstract 1
- 240000009022 Smilax rotundifolia Species 0.000 abstract 1
- 235000003205 Smilax rotundifolia Nutrition 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 230000036407 pain Effects 0.000 description 24
- 208000002193 Pain Diseases 0.000 description 23
- 210000004369 blood Anatomy 0.000 description 21
- 239000008280 blood Substances 0.000 description 21
- 210000004185 liver Anatomy 0.000 description 17
- 230000002401 inhibitory effect Effects 0.000 description 16
- 230000000144 pharmacologic effect Effects 0.000 description 16
- 231100000614 poison Toxicity 0.000 description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 14
- 238000011160 research Methods 0.000 description 14
- 201000010099 disease Diseases 0.000 description 13
- 239000003440 toxic substance Substances 0.000 description 13
- 206010007247 Carbuncle Diseases 0.000 description 11
- 210000000952 spleen Anatomy 0.000 description 11
- 230000008961 swelling Effects 0.000 description 11
- 210000001015 abdomen Anatomy 0.000 description 10
- 208000001848 dysentery Diseases 0.000 description 10
- 210000002784 stomach Anatomy 0.000 description 10
- 230000000844 anti-bacterial effect Effects 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 8
- 230000001154 acute effect Effects 0.000 description 8
- 230000003110 anti-inflammatory effect Effects 0.000 description 8
- 210000000214 mouth Anatomy 0.000 description 8
- 208000024891 symptom Diseases 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 230000003115 biocidal effect Effects 0.000 description 7
- 229930182470 glycoside Natural products 0.000 description 7
- 210000004291 uterus Anatomy 0.000 description 7
- 230000001754 anti-pyretic effect Effects 0.000 description 6
- 239000002221 antipyretic Substances 0.000 description 6
- 150000002338 glycosides Chemical class 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 6
- 210000003734 kidney Anatomy 0.000 description 6
- 239000000729 antidote Substances 0.000 description 5
- 230000036760 body temperature Effects 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 5
- 210000000232 gallbladder Anatomy 0.000 description 5
- 210000004072 lung Anatomy 0.000 description 5
- 238000002560 therapeutic procedure Methods 0.000 description 5
- XVPBINOPNYFXID-JARXUMMXSA-N 85u4c366qs Chemical compound C([C@@H]1CCC[N@+]2(CCC[C@H]3[C@@H]21)[O-])N1[C@@H]3CCCC1=O XVPBINOPNYFXID-JARXUMMXSA-N 0.000 description 4
- 206010017553 Furuncle Diseases 0.000 description 4
- 206010030113 Oedema Diseases 0.000 description 4
- 208000003251 Pruritus Diseases 0.000 description 4
- 206010037660 Pyrexia Diseases 0.000 description 4
- 241000191967 Staphylococcus aureus Species 0.000 description 4
- 230000005856 abnormality Effects 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 239000003146 anticoagulant agent Substances 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- QBKSWRVVCFFDOT-UHFFFAOYSA-N gossypol Chemical compound CC(C)C1=C(O)C(O)=C(C=O)C2=C(O)C(C=3C(O)=C4C(C=O)=C(O)C(O)=C(C4=CC=3C)C(C)C)=C(C)C=C21 QBKSWRVVCFFDOT-UHFFFAOYSA-N 0.000 description 4
- 210000002429 large intestine Anatomy 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 229930015582 oxymatrine Natural products 0.000 description 4
- 210000000496 pancreas Anatomy 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 208000011580 syndromic disease Diseases 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- HDXIQHTUNGFJIC-UHFFFAOYSA-N (25R)-spirost-5-en-3beta-ol 3-O-<O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside> Natural products O1C2(OCC(C)CC2)C(C)C(C2(CCC3C4(C)CC5)C)C1CC2C3CC=C4CC5OC1OC(CO)C(O)C(O)C1OC1OC(C)C(O)C(O)C1O HDXIQHTUNGFJIC-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 208000006820 Arthralgia Diseases 0.000 description 3
- 208000008035 Back Pain Diseases 0.000 description 3
- 241000606161 Chlamydia Species 0.000 description 3
- 208000003322 Coinfection Diseases 0.000 description 3
- VNONINPVFQTJOC-RXEYMUOJSA-N Collettiside III Natural products O([C@@H]1[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O2)[C@H](CO)O[C@@H]1O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]5[C@H](C)[C@@]6(O[C@H]5C4)OC[C@H](C)CC6)CC3)CC=2)CC1)[C@H]1[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O1 VNONINPVFQTJOC-RXEYMUOJSA-N 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- -1 Forsythinol glycoside Chemical class 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- ZSBXGIUJOOQZMP-UHFFFAOYSA-N Isomatrine Natural products C1CCC2CN3C(=O)CCCC3C3C2N1CCC3 ZSBXGIUJOOQZMP-UHFFFAOYSA-N 0.000 description 3
- 208000008930 Low Back Pain Diseases 0.000 description 3
- ZSBXGIUJOOQZMP-JLNYLFASSA-N Matrine Chemical compound C1CC[C@H]2CN3C(=O)CCC[C@@H]3[C@@H]3[C@H]2N1CCC3 ZSBXGIUJOOQZMP-JLNYLFASSA-N 0.000 description 3
- 241000204031 Mycoplasma Species 0.000 description 3
- 201000007100 Pharyngitis Diseases 0.000 description 3
- 208000008350 Pruritus Vulvae Diseases 0.000 description 3
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 3
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 3
- 241000194017 Streptococcus Species 0.000 description 3
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 206010056530 Vulvovaginal pruritus Diseases 0.000 description 3
- 206010048245 Yellow skin Diseases 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 3
- 230000002146 bilateral effect Effects 0.000 description 3
- VNONINPVFQTJOC-ZGXDEBHDSA-N dioscin Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O[C@H]1[C@@H]([C@H](O)[C@@H](O)[C@H](C)O1)O)O[C@@H]1CC2=CC[C@H]3[C@@H]4C[C@H]5[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@@H]([C@]1(OC[C@H](C)CC1)O5)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O VNONINPVFQTJOC-ZGXDEBHDSA-N 0.000 description 3
- CJNUQCDDINHHHD-APRUHSSNSA-N dioscin Natural products C[C@@H]1CC[C@@]2(OC1)O[C@H]3C[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@H]6[C@H]5CC[C@]4(C)[C@H]3[C@@H]2C)O[C@@H]7O[C@H](CO)[C@@H](O[C@@H]8O[C@@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@H](O)[C@H]7O[C@@H]9O[C@@H](C)[C@H](O)[C@@H](O)[C@H]9O CJNUQCDDINHHHD-APRUHSSNSA-N 0.000 description 3
- 229930003944 flavone Natural products 0.000 description 3
- 150000002212 flavone derivatives Chemical class 0.000 description 3
- 235000011949 flavones Nutrition 0.000 description 3
- 230000002949 hemolytic effect Effects 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 241000411851 herbal medicine Species 0.000 description 3
- 210000003026 hypopharynx Anatomy 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 230000002147 killing effect Effects 0.000 description 3
- 201000005630 leukorrhea Diseases 0.000 description 3
- 229930014456 matrine Natural products 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- VNONINPVFQTJOC-UHFFFAOYSA-N polyphyllin III Natural products O1C2(OCC(C)CC2)C(C)C(C2(CCC3C4(C)CC5)C)C1CC2C3CC=C4CC5OC(C(C1O)OC2C(C(O)C(O)C(C)O2)O)OC(CO)C1OC1OC(C)C(O)C(O)C1O VNONINPVFQTJOC-UHFFFAOYSA-N 0.000 description 3
- 229930182490 saponin Natural products 0.000 description 3
- 150000007949 saponins Chemical class 0.000 description 3
- 235000017709 saponins Nutrition 0.000 description 3
- 210000000813 small intestine Anatomy 0.000 description 3
- 230000000392 somatic effect Effects 0.000 description 3
- 238000002604 ultrasonography Methods 0.000 description 3
- 206010046901 vaginal discharge Diseases 0.000 description 3
- 239000002435 venom Substances 0.000 description 3
- 210000001048 venom Anatomy 0.000 description 3
- 231100000611 venom Toxicity 0.000 description 3
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 3
- 239000000341 volatile oil Substances 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 2
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 208000004145 Endometritis Diseases 0.000 description 2
- 201000000297 Erysipelas Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000192125 Firmicutes Species 0.000 description 2
- 241000521257 Hydrops Species 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- 206010057071 Rectal tenesmus Diseases 0.000 description 2
- 241000531795 Salmonella enterica subsp. enterica serovar Paratyphi A Species 0.000 description 2
- 208000007893 Salpingitis Diseases 0.000 description 2
- 206010040943 Skin Ulcer Diseases 0.000 description 2
- AAGFPTSOPGCENQ-UHFFFAOYSA-N Sophocarpin I Natural products C1CCC2CN3C(=O)C=CCC3C3C2N1CCC3 AAGFPTSOPGCENQ-UHFFFAOYSA-N 0.000 description 2
- IGXQFUGORDJEST-UHFFFAOYSA-N Sophocarpine Natural products O=C1C=CCC2C3CCCC4CCCC(CN12)C34 IGXQFUGORDJEST-UHFFFAOYSA-N 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 241000605008 Spirillum Species 0.000 description 2
- QHOPXUFELLHKAS-UHFFFAOYSA-N Thespesin Natural products CC(C)c1c(O)c(O)c2C(O)Oc3c(c(C)cc1c23)-c1c2OC(O)c3c(O)c(O)c(C(C)C)c(cc1C)c23 QHOPXUFELLHKAS-UHFFFAOYSA-N 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000002785 anti-thrombosis Effects 0.000 description 2
- 230000000259 anti-tumor effect Effects 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- QXMNTPFFZFYQAI-IMDKZJJXSA-N beta-sitosterol 3-O-beta-D-glucopyranoside Natural products CC[C@H](CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)O[C@@H]5C[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)C(C)C QXMNTPFFZFYQAI-IMDKZJJXSA-N 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 206010006451 bronchitis Diseases 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- NPJICTMALKLTFW-OFUAXYCQSA-N daucosterol Chemical compound O([C@@H]1CC2=CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CC[C@@H](CC)C(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O NPJICTMALKLTFW-OFUAXYCQSA-N 0.000 description 2
- QDFKFNAHVGPRBL-UHFFFAOYSA-N daucosterol Natural products CCC(CCC(C)C1CCC2C1CCC3C2(C)CC=C4CC(CCC34C)OC5OC(CO)C(O)C(O)C5O)C(C)C QDFKFNAHVGPRBL-UHFFFAOYSA-N 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 208000001780 epistaxis Diseases 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 208000003512 furunculosis Diseases 0.000 description 2
- 229930000755 gossypol Natural products 0.000 description 2
- 229950005277 gossypol Drugs 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 208000021267 infertility disease Diseases 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 230000009545 invasion Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 201000007227 lymph node tuberculosis Diseases 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 210000003101 oviduct Anatomy 0.000 description 2
- 244000045947 parasite Species 0.000 description 2
- 150000002989 phenols Chemical class 0.000 description 2
- 230000007096 poisonous effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- RNYZJZKPGHQTJR-UHFFFAOYSA-N protoanemonin Chemical compound C=C1OC(=O)C=C1 RNYZJZKPGHQTJR-UHFFFAOYSA-N 0.000 description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 2
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 2
- 231100000019 skin ulcer Toxicity 0.000 description 2
- 230000035943 smell Effects 0.000 description 2
- AAGFPTSOPGCENQ-JLNYLFASSA-N sophocarpine Chemical compound C1CC[C@H]2CN3C(=O)C=CC[C@@H]3[C@@H]3[C@H]2N1CCC3 AAGFPTSOPGCENQ-JLNYLFASSA-N 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- CWVRJTMFETXNAD-BMNNCGMMSA-N (1s,3r,4s,5r)-3-[(e)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,4,5-trihydroxycyclohexane-1-carboxylic acid Chemical compound O[C@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-BMNNCGMMSA-N 0.000 description 1
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 1
- YQEMAEKYNNOCBY-UHFFFAOYSA-N (25R)-diosgenin-3-O-beta-D-glucopyranosyl(1-3)-[alpha-L-rhamnopyranosyl(1-2)]-beta-D-glucopyranoside Natural products O1C2(OCC(C)CC2)C(C)C(C2(CCC3C4(C)CC5)C)C1CC2C3CC=C4CC5OC(C1OC2C(C(O)C(O)C(C)O2)O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1O YQEMAEKYNNOCBY-UHFFFAOYSA-N 0.000 description 1
- KKQQPVXVNRLUKV-UHFFFAOYSA-N (25S)-2beta-(alpha-L-arabinopyranosyloxy)-5beta-spirostan-3alpha-ol, Yononin Natural products O1C2(OCC(C)CC2)C(C)C(C2(CCC3C4(C)C5)C)C1CC2C3CCC4CC(O)C5OC1OCC(O)C(O)C1O KKQQPVXVNRLUKV-UHFFFAOYSA-N 0.000 description 1
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 1
- CPGCVOVWHCWVTP-LJAQVGFWSA-N (S)-nonacosan-10-ol Chemical compound CCCCCCCCCCCCCCCCCCC[C@@H](O)CCCCCCCCC CPGCVOVWHCWVTP-LJAQVGFWSA-N 0.000 description 1
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
- ICWHTQRTTHCUHW-IPYPFGDCSA-N 2-[(3s,5r,6r)-6,10-dimethylspiro[4.5]dec-9-en-3-yl]propan-2-ol Chemical compound C[C@@H]1CCC=C(C)[C@]11C[C@@H](C(C)(C)O)CC1 ICWHTQRTTHCUHW-IPYPFGDCSA-N 0.000 description 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- GVRNTWSGBWPJGS-YSDSKTICSA-N 4-[2-[(1r,4as,5r,6r,8as)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1h-naphthalen-1-yl]ethyl]-2h-furan-5-one Chemical compound C([C@H]1[C@]2(C)CC[C@@H](O)[C@]([C@H]2CCC1=C)(CO)C)CC1=CCOC1=O GVRNTWSGBWPJGS-YSDSKTICSA-N 0.000 description 1
- YGCYRQKJYWQXHG-RDNQFMDVSA-N 4-[2-[(1r,4as,5r,8as)-5,8a-dimethyl-2-methylidene-5-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3,4,4a,6,7,8-hexahydro-1h-naphthalen-1-yl]ethyl]-2h-furan-5-one Chemical compound C([C@@]1(C)[C@H]2CCC(=C)[C@@H](CCC=3C(OCC=3)=O)[C@]2(C)CCC1)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YGCYRQKJYWQXHG-RDNQFMDVSA-N 0.000 description 1
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 1
- 206010000084 Abdominal pain lower Diseases 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010000228 Abortion infected Diseases 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- PLXMOAALOJOTIY-FPTXNFDTSA-N Aesculin Natural products OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1Oc2cc3C=CC(=O)Oc3cc2O PLXMOAALOJOTIY-FPTXNFDTSA-N 0.000 description 1
- ICWHTQRTTHCUHW-UHFFFAOYSA-N Agarospirol Natural products CC1CCC=C(C)C11CC(C(C)(C)O)CC1 ICWHTQRTTHCUHW-UHFFFAOYSA-N 0.000 description 1
- 208000008710 Amebic Dysentery Diseases 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010001986 Amoebic dysentery Diseases 0.000 description 1
- BOJKULTULYSRAS-OTESTREVSA-N Andrographolide Chemical compound C([C@H]1[C@]2(C)CC[C@@H](O)[C@]([C@H]2CCC1=C)(CO)C)\C=C1/[C@H](O)COC1=O BOJKULTULYSRAS-OTESTREVSA-N 0.000 description 1
- ZROGCCBNZBKLEL-FHXNIQKESA-N Astilbin Natural products O([C@H]1[C@@H](c2cc(O)c(O)cc2)Oc2c(c(O)cc(O)c2)C1=O)[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](C)O1 ZROGCCBNZBKLEL-FHXNIQKESA-N 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- TYPSVDGIQAOBAD-DZGCQCFKSA-N Atractylone Chemical compound C([C@]1(C)C2)CCC(=C)[C@@H]1CC1=C2OC=C1C TYPSVDGIQAOBAD-DZGCQCFKSA-N 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 208000027496 Behcet disease Diseases 0.000 description 1
- 208000009137 Behcet syndrome Diseases 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 206010007134 Candida infections Diseases 0.000 description 1
- 241000208365 Celastraceae Species 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 206010009152 Chronic tonsillitis Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012434 Dermatitis allergic Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- 239000001263 FEMA 3042 Substances 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- KFFCKOBAHMGTMW-LGQRSHAYSA-N Forsythin Chemical compound C1=C(OC)C(OC)=CC=C1[C@H]1[C@@H](CO[C@@H]2C=3C=C(OC)C(O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)=CC=3)[C@@H]2CO1 KFFCKOBAHMGTMW-LGQRSHAYSA-N 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- 206010018286 Gingival pain Diseases 0.000 description 1
- 206010018291 Gingival swelling Diseases 0.000 description 1
- YQEMAEKYNNOCBY-IEMDQPGHSA-N Gracillin Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@H](O)[C@@H](O)[C@H](C)O1)O)O[C@@H]1CC2=CC[C@H]3[C@@H]4C[C@H]5[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@@H]([C@]1(OC[C@H](C)CC1)O5)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YQEMAEKYNNOCBY-IEMDQPGHSA-N 0.000 description 1
- 206010018691 Granuloma Diseases 0.000 description 1
- 206010018693 Granuloma inguinale Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 241000762515 Hydrosalpinx Species 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241000712431 Influenza A virus Species 0.000 description 1
- VQUPQWGKORWZII-RPJYBVRZSA-N Isoengeletin Chemical compound C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@H]2[C@H](OC3=CC(=CC(=C3C2=O)O)O)C4=CC=C(C=C4)O)O)O)O VQUPQWGKORWZII-RPJYBVRZSA-N 0.000 description 1
- 241000589902 Leptospira Species 0.000 description 1
- 241000701076 Macacine alphaherpesvirus 1 Species 0.000 description 1
- 208000005647 Mumps Diseases 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- NEEQFPMRODQIKX-REOHCLBHSA-N N(3)-oxalyl-L-2,3-diaminopropionic acid Chemical compound OC(=O)[C@@H](N)CNC(=O)C(O)=O NEEQFPMRODQIKX-REOHCLBHSA-N 0.000 description 1
- 241000475481 Nebula Species 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- VQUPQWGKORWZII-UHFFFAOYSA-N Neoisoengelitin Natural products OC1C(O)C(O)C(C)OC1OC1C(=O)C2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C=C1 VQUPQWGKORWZII-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 206010033078 Otitis media Diseases 0.000 description 1
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 description 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
- 206010067781 Pharyngeal abscess Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 241000218206 Ranunculus Species 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 208000003801 Retropharyngeal Abscess Diseases 0.000 description 1
- 241001354013 Salmonella enterica subsp. enterica serovar Enteritidis Species 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 241000607762 Shigella flexneri Species 0.000 description 1
- 235000000336 Solanum dulcamara Nutrition 0.000 description 1
- 241000191984 Staphylococcus haemolyticus Species 0.000 description 1
- 241001062472 Stokellia anisodon Species 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 206010043458 Thirst Diseases 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 206010043866 Tinea capitis Diseases 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 208000007074 Trichomonas Vaginitis Diseases 0.000 description 1
- 208000025206 Trichomonas vaginitis urogenital infection Diseases 0.000 description 1
- AXMVYSVVTMKQSL-UHFFFAOYSA-N UNPD142122 Natural products OC1=CC=C(C=CC=O)C=C1O AXMVYSVVTMKQSL-UHFFFAOYSA-N 0.000 description 1
- HZYXFRGVBOPPNZ-UHFFFAOYSA-N UNPD88870 Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)=CCC(CC)C(C)C)C1(C)CC2 HZYXFRGVBOPPNZ-UHFFFAOYSA-N 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 241000607626 Vibrio cholerae Species 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 201000004171 acute endometritis Diseases 0.000 description 1
- 208000012873 acute gastroenteritis Diseases 0.000 description 1
- 208000016150 acute pharyngitis Diseases 0.000 description 1
- 206010001093 acute tonsillitis Diseases 0.000 description 1
- QNHQEUFMIKRNTB-UHFFFAOYSA-N aesculetin Natural products C1CC(=O)OC2=C1C=C(O)C(O)=C2 QNHQEUFMIKRNTB-UHFFFAOYSA-N 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- UPEZCKBFRMILAV-UHFFFAOYSA-N alpha-Ecdysone Natural products C1C(O)C(O)CC2(C)C(CCC3(C(C(C(O)CCC(C)(C)O)C)CCC33O)C)C3=CC(=O)C21 UPEZCKBFRMILAV-UHFFFAOYSA-N 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- ASLUCFFROXVMFL-UHFFFAOYSA-N andrographolide Natural products CC1(CO)C(O)CCC2(C)C(CC=C3/C(O)OCC3=O)C(=C)CCC12 ASLUCFFROXVMFL-UHFFFAOYSA-N 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000001088 anti-asthma Effects 0.000 description 1
- 230000001716 anti-fugal effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- ZROGCCBNZBKLEL-MPRHSVQHSA-N astilbin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1C(=O)C2=C(O)C=C(O)C=C2O[C@@H]1C1=CC=C(O)C(O)=C1 ZROGCCBNZBKLEL-MPRHSVQHSA-N 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000009172 bursting Effects 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 1
- 201000003984 candidiasis Diseases 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- CPGCVOVWHCWVTP-UHFFFAOYSA-N celidoniol Natural products CCCCCCCCCCCCCCCCCCCC(O)CCCCCCCCC CPGCVOVWHCWVTP-UHFFFAOYSA-N 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 description 1
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 description 1
- 229940117916 cinnamic aldehyde Drugs 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- 229940124579 cold medicine Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- MEEPUSVTMHGIPC-UHFFFAOYSA-N deoxyandrographiside Natural products OC1CCC2(C)C(CCC=3C(OCC=3)=O)C(=C)CCC2C1(C)COC1OC(CO)C(O)C(O)C1O MEEPUSVTMHGIPC-UHFFFAOYSA-N 0.000 description 1
- GVRNTWSGBWPJGS-UHFFFAOYSA-N deoxyandrographolide Natural products C=C1CCC2C(C)(CO)C(O)CCC2(C)C1CCC1=CCOC1=O GVRNTWSGBWPJGS-UHFFFAOYSA-N 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 201000003511 ectopic pregnancy Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- ILEDWLMCKZNDJK-UHFFFAOYSA-N esculetin Chemical compound C1=CC(=O)OC2=C1C=C(O)C(O)=C2 ILEDWLMCKZNDJK-UHFFFAOYSA-N 0.000 description 1
- XHCADAYNFIFUHF-TVKJYDDYSA-N esculin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC2=C1OC(=O)C=C2 XHCADAYNFIFUHF-TVKJYDDYSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000002481 ethanol extraction Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 208000024756 faint Diseases 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 229930182486 flavonoid glycoside Natural products 0.000 description 1
- 150000007955 flavonoid glycosides Chemical class 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 229930182494 ginsenoside Natural products 0.000 description 1
- 229940089161 ginsenoside Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- LDDIPQISQQULJN-DCXLXNQSSA-N gracillin Natural products C[C@@H]1CC[C@@]2(OC1)O[C@H]3C[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@H]6[C@H]5CC[C@]4(C)[C@H]3[C@@H]2C)O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@H]7O[C@@H]9O[C@@H](C)[C@H](O)[C@@H](O)[C@H]9O LDDIPQISQQULJN-DCXLXNQSSA-N 0.000 description 1
- 210000001126 granulation tissue Anatomy 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 208000030843 hydrosalpinx Diseases 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 201000007772 internal hemorrhoid Diseases 0.000 description 1
- KRZBCHWVBQOTNZ-DLDRDHNVSA-N isochlorogenic acid Natural products O[C@@H]1[C@H](C[C@@](O)(C[C@H]1OC(=O)C=Cc2ccc(O)c(O)c2)C(=O)O)OC(=O)C=Cc3ccc(O)c(O)c3 KRZBCHWVBQOTNZ-DLDRDHNVSA-N 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- LHHAGBJPCRSFHH-UHFFFAOYSA-N lilioglycoside G Natural products CC1CCC2(OC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(CO)C(O)C(OC8OC(CO)C(O)C(O)C8OC9OC(C)C(O)C(O)C9O)C7O LHHAGBJPCRSFHH-UHFFFAOYSA-N 0.000 description 1
- 208000030208 low-grade fever Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 208000007106 menorrhagia Diseases 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 208000010553 multiple abscesses Diseases 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- BBGWVUQBIGGVLS-UHFFFAOYSA-N neoandrographolide Natural products CC1(COC2OC(CO)C(O)C(O)C2O)C(O)CCC3(C)C(CCC4=C(O)COC4=O)C(=C)CCC13 BBGWVUQBIGGVLS-UHFFFAOYSA-N 0.000 description 1
- YGCYRQKJYWQXHG-UHFFFAOYSA-N neoandrographoside Natural products C1CCC2(C)C(CCC=3C(OCC=3)=O)C(=C)CCC2C1(C)COC1OC(CO)C(O)C(O)C1O YGCYRQKJYWQXHG-UHFFFAOYSA-N 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- YKRGDOXKVOZESV-UHFFFAOYSA-N paeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(CO)O5)O)CC3(O)OC1C24COC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-UHFFFAOYSA-N 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 208000010669 pelvic lump Diseases 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 210000004303 peritoneum Anatomy 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 210000001369 pituitary-adrenal system Anatomy 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229930191447 pulchinenoside Natural products 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000008517 radix Trichosanthis Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 239000003998 snake venom Substances 0.000 description 1
- 229940037649 staphylococcus haemolyticus Drugs 0.000 description 1
- 229930002600 steroidal saponin Natural products 0.000 description 1
- HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 description 1
- 229940032091 stigmasterol Drugs 0.000 description 1
- BFDNMXAIBMJLBB-UHFFFAOYSA-N stigmasterol Natural products CCC(C=CC(C)C1CCCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C BFDNMXAIBMJLBB-UHFFFAOYSA-N 0.000 description 1
- 235000016831 stigmasterol Nutrition 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 201000009642 tinea barbae Diseases 0.000 description 1
- 208000009189 tinea favosa Diseases 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 229930182493 triterpene saponin Natural products 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及一种治疗慢性盆腔炎的中药制剂。其技术方案是由以下重量份的中药制成:山豆根50—100份、七叶一枝花6090份、连翘50—90份、金银花5070份、穿心莲50—70份、土茯苓5070份、白头翁5070份、乌蔹莓6090份、秦皮5070份、苍术5070份、萆薢5070份、赤芍5070份、三七2050份、肉桂3070份。本发明的有益效果是:本发明中的山豆根苦寒清热为君;七叶一枝花等清热解毒,应用于临床实验已经十余年,疗效好,较同类药物如金鸡胶囊、妇炎康、花红片有明显的优势,且可以减少抗生素的应用,对抗生素治疗无效,耐药菌株感染者亦有明显疗效。
Description
技术领域
本发明涉及一种中药制剂,特别涉及一种治疗慢性盆腔炎的中药制剂。
背景技术
慢性盆腔炎是由细菌、支原体、衣原体、滴虫等病原微生物单独或混合感染所致,主要包括子宫内膜炎、输卵管炎、盆腔腹膜炎等,可局限于一个部位,也可涉及整个内生殖器及盆腔腹膜,是妇科常见病、多发病。中医认为此类疾病为湿热下注、湿热兼血瘀所致,其根本病因多为湿热,属带下病范畴。常见少腹坠痛、腰痛、外阴瘙痒、月经量多有血块、经期腹痛、白带量多色黄或血性白带、有异味等症状,易造成输卵管粘连、阻塞,导致不孕,宫外孕等,严重影响广大妇女身心健康。
目前治疗该病的方法主要包括抗生素、中药煎剂、中成药,抗生素对急性细菌感染疗效尚可,对慢性细菌感染或细菌、支原体、衣原体混合感染,疗效不佳,且反复应用易致耐药菌株产生,而治疗无效;中药煎剂因味苦、服用、携带不方便,患者不易接受。常用中成药疗效较好者有金鸡胶囊、妇炎康、花红片等,金鸡胶囊内有清热解毒作用的仅功劳木、两面针、穿心莲等,妇炎康内有清热解毒作用的仅有柴胡、黄芩、败酱草等,花红片内有清热解毒作用的仅有一点红、白花蛇舌草、地桃花、菥蓂等,其清热解毒作用明显不足。还有如中国专利文献公开号为101966301A,专利名称为《一种治疗盆腔炎的中药组合物及其制备方法》,本发明中药组合物主要由以下原料药组成:苦参、玄参、栀子、蒲公英、地丁、连翘、防风、生地黄、紫草、葛根、石膏、知母、芦根、白茅根、天花粉、淡竹叶、黄连、秦皮、白癣皮、败酱草、牡丹皮、地骨皮、广木香、茜草、降香、川芎、郁金、丹参、益母草等,也是存在效果不好的问题,特别是清热解毒作用不足。
发明内容
本发明的目的就是针对现有技术存在的上述缺陷,提供一种治疗慢性盆腔炎的中药制剂,解决抗生素对慢性炎症疗效不好、中药煎剂因口味不佳、服用、携带不便等不易为病人接受、中成药疗效欠佳等问题。
本发明提到的一种治疗慢性盆腔炎的中药制剂,其技术方案是由以下重量份的中药制成:
山豆根50—100份、七叶一枝花60-90份、连翘50—90份、金银花50-70份、穿心莲50—70份、土茯苓50-70份、白头翁50-70份、乌蔹莓60-90份、秦皮50-70份、苍术50-70份、萆薢50-70份、赤芍50-70份、三七20-50份、肉桂30-70份。
优选的,本发明由以下重量份的中药制成:
山豆根50—70份、七叶一枝花70-90份、连翘50—70份、金银花50-70份、穿心莲50—70份、土茯苓50-70份、白头翁50-70份、乌蔹莓70-90份、秦皮50-70份、苍术50-70份、萆薢50-70份、赤芍60-70份、三七30-40份、肉桂40-70份。
进一步优选的,本发明由以下重量份的中药制成:
山豆根70份、七叶一枝花70份、连翘90份、金银花70份、穿心莲70份、土茯苓70份、白头翁70份、乌蔹莓90份、秦皮70份、苍术70份、萆薢70份、赤芍70份、三七30份、肉桂70份。
本发明的制备方法是:将上述重量份的药物分别粉碎成最粗粉,将粉碎后药物混合,用水提取法常规提取两次,提取物减压干燥粉碎成细粉,加入淀粉(或/和)羧甲基淀粉钠5-15重量份为辅料,混匀制成0.5克/片的药片,或制成0.3克/粒胶囊备用。
本发明的机理是:
山豆根:味甘,寒,无毒。归心,肺、大肠三经。功效:清热,解毒,消肿,止痛。主治:喉痈,喉风,喉痹,牙龈肿痛,喘满热咳,黄疸,下痢,痔疾,热肿,秃疮,疥癣,蛇、虫、犬咬伤。
《开宝本草》:"主解诸药毒,止痛。消疮肿毒,急黄发热咳嗽,杀小虫。"
《本草求真》曰:“山豆根,功专泻心保肺,及降阴经火逆,解咽喉肿痈第一要药。”《本草汇言》曰:“山豆根,苦寒清肃,得降下之令,善除肺胃郁热,凡一切暴感热疾,凉而解毒,表里上下,无不宜之。”
现代药理研究证实,山豆根含苦参碱、氧化苦参碱、槐果碱 、苦参苷、氧化苦参碱等。其中苦参碱、氧化苦参碱、槐果碱等具有显著的抗炎作用。苦参苷对小鼠腹腔毛细血管通透性增高、大鼠足肿胀和棉球肉芽肿均有明显的抑制作用。氧化苦参碱能使大鼠正常体温显著降低,使家兔发热明显下降。山豆根在体外实验中有一定的抗菌作用。苦参碱对多种细菌有显著的抑制作用。山豆根水煎液有较强的抗柯萨奇病毒B5的作用。山豆根对螺旋体和真菌有抑制作用。
七叶一枝花:苦,微寒。有小毒。归肝经。 功效:清热解毒,消肿止痛,凉肝定惊。主治:痈肿疔疮,咽喉肿痛,毒蛇咬伤,惊风抽搐,跌打损伤。本品苦以降泄,寒能清热,故有清热解毒,消肿止痛之功,为治痈肿疔毒,毒蛇咬伤的常用药。
现代研究:本品含蚤休苷、薯蓣皂苷,单宁酸及18种氨基酸,肌酸酐,生物碱,黄酮,甾酮,蜕皮激素,胡萝卜苷等。药理作用:蚤休有广谱抗菌作用,对痢疾杆菌、伤寒杆菌、大肠杆菌、肠炎杆菌、绿脓杆菌、金黄色葡萄球菌、溶血性链球菌、脑膜炎双球菌等均有不同程度的抑制作用,尤其对化脓性球菌的抑制作用优于黄连;对亚洲甲型流感病毒有较强的抑制作用;所含甾体皂苷和氨基酸有抗蛇毒作用;蚤休苷有镇静、镇痛作用;本品的水煎剂或乙醇提取物有明显的镇咳、平喘作用;蚤休粉有明显的止血作用;
连翘:苦辛,微寒,入心、小肠经。功效:清热解毒、疏风热、解暑热。《中药大辞典》载其“清热解毒,散结消肿。”现代药理研究:本品含多种酚类化合物连翘甙、连翘醇甙等,其水煎剂具有广谱抗菌作用,对革兰氏阳性菌、革兰氏阴性菌作用均强,对流感病毒、念珠菌亦有抗菌作用。
金银花:性寒,味甘,入肺、心、胃经。功效:清热解毒,疏散风热。主治痈肿疔毒初起,红肿热痛,外感风热,温病初起,热毒血痢,暑热烦渴,咽喉肿痛。现代药理研究:本品含绿原酸,异绿原酸,白果醇,β-谷甾醇,豆甾醇等等。水煎剂有抗病原微生物作用,体外实验表明,金银花水煎剂对多种致病菌如金黄色葡萄球菌、溶血性链球菌、大肠杆菌、痢疾杆菌、霍乱弧菌、伤寒杆菌、副伤寒杆菌等均有一定抑制作用,对肺炎球菌、脑膜炎双球菌、绿脓杆菌,结核杆菌亦有效。
穿心莲:苦,寒,归肺、胃、大肠、小肠经。功效:清热解毒,凉血消肿。现代药理研究:穿心莲含二萜内酯化合物:去氧穿心莲内酯,穿心莲内酯,新穿心莲内酯;及高穿心莲内酯,潘尼内酯等。其水煎剂对金黄色葡萄球菌、绿脓杆菌等有不同程度的抑制作用,并有解热抗炎,增强机体免疫功能等作用。临床上常用于多种感染性疾病,包括外伤感染、疖、痈、丹毒、上呼吸道感染、急慢性扁桃体炎、急慢性咽喉炎、急慢性支气管炎、急性菌痢、急性胃肠炎、尿路感染、子宫内膜炎、盆腔炎、中耳炎、牙周炎等,均有不同程度的疗效。
土茯苓:味甘、淡,性平,归肝、胃经。功效:清热解毒,除湿通络。主治湿热疮毒,痈肿梅毒,瘰疬疮肿,筋骨挛痛。《滇南本草》单用本品水煎服,治疗阴痒带下。现代药理研究:本品含落新妇苷、异黄杞苷、胡萝卜苷、琥珀酸、β-谷甾醇,还含黄酮、皂苷、树脂、多糖、淀粉、挥发油等成分。药理作用 :1、免疫抑制和抗炎,对细胞免疫有抑制作用。有抗炎、抗菌、抗真菌作用。2、解毒 ,对急性和亚急性棉酚中毒有保护作用,但不影响棉酚抑制精子生成的作用。临床应用1.病毒感染性口腔溃疡。2.过敏性皮疹、皮肤溃疡或有继发感染。3.白塞病口腔、阴部溃疡,关节痛。4.病毒、螺旋体等引起的性病感染、溃疡。
白头翁:性味,味苦;性寒。归经,入大肠、肝、胃经。功效:清热解毒,凉血止痢,燥湿杀虫。主赤白痢疾、鼻衄、崩漏、血痔、寒热温疟、带下、阴痒、湿疹、瘰疬、痈疮、眼目赤痛。用于热毒血痢,阴痒带下,阿米巴痢。现代药理研究:本品含毛莨苷类原白头翁素和三萜皂苷类白头翁皂苷等成分。水煎剂对多种细菌、阿米巴原虫有显著的抑制作用,对阴道滴虫有明显的杀灭作用。
乌蔹莓:苦、酸,寒。归心、肝、小肠经。功效:清热解毒,利湿,消肿,活血化瘀。主治:咽喉肿痛,目翳,咯血,尿血,痢疾,治湿热白浊;外用于痈肿,丹毒,痄腮,跌打损伤,毒蛇咬伤。现代药理研究:
1. 抑菌试验:本品对溶血性葡萄球菌、溶血性链球菌、痢疾杆菌、大肠杆菌、均有抑制作用。
2. 其水煎剂对钩端螺旋体有抑制作用。
3. 乌蔹莓水煎酒沉液及醇沉液对不同的炎症模型均有不同程度的对抗作用,对以渗出和肉芽组织增生为主的炎症过程均有抑制作用,其抗炎作用与垂体-肾上腺系统无明显关系。
秦皮:味苦,寒,归肝、胆、大肠经。功效:清热燥湿,清肝明目,收涩止痢,止带。主治:热毒泻痢,带下阴痒,肝热目赤肿痛,目生翳障。 现代药理研究:本品含马栗树皮甙、马栗树皮素等,有抗炎、止咳、平喘、抗病原微生物、抗肿瘤、抗凝和抗过敏、利尿、止汗、抗氧化和清除自由基等作用。秦皮水提液对金黄色葡萄球菌、伤寒杆菌、副伤寒杆菌、福氏痢疾杆菌、宋内氏痢疾杆菌有明显的抑制作用。
苍术:辛、苦、温,归脾、胃、肝经。功效:燥湿,健脾,去风湿,解表。主治:湿阻脾胃、脘腹胀满,寒湿白带,湿温病以及湿热下注、脚膝肿痛、痿软无力。《本草纲目》载其“治湿痰留饮,或挟瘀血成巢囊,及脾湿下流,浊沥带下,....”现代药理研究:本品含挥发油,油中主要成分苍术醇、茅术醇有抑菌作用。
萆薢:苦甘,平,入肝、肾、胃经。功效:利湿去浊,祛风除痹。主治:淋浊白带、腰膝痹痛,湿热疮毒。现代药理研究:本品含薯蓣皂甙、尚含纤细薯蓣甙、薯蓣皂素毒甙 A、B、山萆薢皂甙、约诺皂甙、托克皂甙元-1-葡萄糖甙等皂甙。薯蓣皂甙、克拉塞林甙还有杭真菌作用(如须癣毛菌)。
赤芍:酸、苦、凉,入肝、脾经。功用主治,行瘀,止痛,凉血,消肿。《日华子本草》“治风补劳,主女人一切病并产前后诸疾,通月水,退热除烦,......”现代药理研究:芍药含芍药甙、丹皮酚类等。药理作用:有抗凝、抗血栓、调节免疫、抗炎、抗菌等等作用。
三七:味甘、微苦,性温、无毒,归肝、胃经。功效:止血,散瘀,消肿,定痛。主治:吐血,咳血,衄血,便血,血痢,崩漏,症瘕,产后血晕,恶露不下,跌扑瘀血,外伤出血,痈肿疼痛等。《纲目》:止血,散血,定痛。现代药理研究:本品主要有效成分是人参皂苷,并含有黄酮苷、田七氨酸、黄酮等化合物。有止血、抗血栓、促进造血、扩血管、降血压、抗心肌缺血、抗脑缺血、抗心律失常、抗动脉粥样硬化、抗炎、保肝、抗肿瘤、镇痛等作用。
肉桂:辛、甘、热,归脾、肾、心、肝经。功效:补火助阳,散寒止痛,温经通脉。主治:肾阳不足;命门火衰;畏寒肢冷;腰膝酸软;阳痿遗精;小便不利或频数;短气喘促;浮肿尿少诸证;火不归源;宫冷不孕;痛经经闭;产后瘀滞腹痛;阴疽流注;或虚寒痈疡脓成不溃;或溃 后不敛。现代药理研究:本品含挥发油,称桂皮油。油中主要成分为桂皮醛、乙酸桂皮酯、乙酸丙苯酯等。桂皮油对革兰氏阳性菌,革兰氏阴性菌有抑制作用,桂皮的醇及水浸出液对多种致病真菌有一定的抑制作用。
本发明的有益效果是:本发明中的山豆根苦寒清热为君;七叶一枝花、连翘、金银花、穿心莲、土茯苓清热解毒,乌蔹莓、秦皮清热燥湿,白头翁清热、燥湿、杀虫,苍术燥湿、健脾,萆薢利湿、祛浊为臣;赤芍、三七祛瘀、止痛,肉桂,辛温,与上述苦寒药同用,防其苦寒伤阳、败胃,三药共为佐使。诸药合用,共奏清热、解毒、燥湿、杀虫作用;适用于细菌、支原体、衣原体、原虫、真菌等感染引起的慢性盆腔炎等妇科感染性疾病(湿毒或湿热下注证;
另外,本发明应用于临床实验已经十余年,治疗慢性盆腔炎等妇科感染性疾病上百例疗效好,较同类药物如金鸡胶囊、妇炎康、花红片有明显的优势,且可以减少抗生素的应用,对抗生素治疗无效,耐药菌株感染者亦有明显疗效;该发明的组合药方的配伍较佳,且达到较好的临床治疗效果。
具体实施方式
实施例1:本发明提到的一种治疗慢性盆腔炎的中药制剂,其技术方案是由以下重量份的中药制成:
山豆根50份、七叶一枝花60份、连翘50份、金银花50份、穿心莲50份、土茯苓50份、白头翁50份、乌蔹莓60份、秦皮50份、苍术50份、萆薢50份、赤芍50份、三七20份、肉桂30份。
实施例2:本发明提到的一种治疗慢性盆腔炎的中药制剂,其技术方案是由以下重量份的中药制成:
山豆根100份、七叶一枝花90份、连翘90份、金银花70份、穿心莲70份、土茯苓70份、白头翁70份、乌蔹莓90份、秦皮70份、苍术70份、萆薢70份、赤芍70份、三七50份、肉桂70份。本实施例的优点是通过增大山豆根的药剂量,使其苦寒清热效果更佳,且应控制用量,因为山豆根有毒,虚火喉痹及脾胃虚寒泄泻者禁服。。
实施例3:本发明提到的一种治疗慢性盆腔炎的中药制剂,其技术方案是由以下重量份的中药制成:
山豆根70份、七叶一枝花70份、连翘90份、金银花70份、穿心莲70份、土茯苓70份、白头翁70份、乌蔹莓90份、秦皮70份、苍术70份、萆薢70份、赤芍70份、三七30份、肉桂70份。
本发明的制备方法是:将上述原料粉碎成最粗粉,用水提取法常规提取两次,提取物减压干燥粉碎成细粉,加入淀粉50克为辅料,混匀制成0.5克/片的药片备用。每次口服4-6片,每日三次。
取上述提取物减压干燥粉碎,加入适量羧甲基淀粉钠为辅料,混匀制成0.3克/粒的胶囊备用,每次口服6-8粒,每日三次。
临床研究资料:
1.临床资料
病例来源于我院2003~2012年收治门诊病人240例进行临床实验,随机分两组,治疗组 120例,年龄26~52岁;病程0.5~9年;对照组120例年龄24~51岁;病程0.7~8年;所有患者均有下腹部疼痛、胀满,兼腰痛118例,兼白带增多160例,兼肛门坠胀97例,盆腔包块38例,不孕症66例。
诊断标准:依据中华人民共和国卫生部颁布的《中药新药临床研究指导原则》中慢性盆腔炎的中医诊断标准。
符合上述要求的患者,随机进入治疗组,根据病情采用本发明实施例1、2或3中胶囊剂治疗,和对照组,采用妇炎康治疗。治疗组120例,对照组120例。以上患者入组前两周停用其他药物,随后进行两疗程的治疗和两月的随访。
2.治疗方法
治疗组用采用本发明实施例1、2或3中的胶囊剂治疗,每次口服5粒,每日三次。对照组采用妇炎康治疗。两组均两周为一疗程,治疗两疗程后观察疗效。
3.疗效标准:
3.1症状、体征评分标准,参照《中药新药临床研究指导原则》拟定。子宫活动受限、 压痛 5分,输卵管呈条索状、 压痛 5分 ,下腹腰部酸痛下坠 3分,子宫一侧或两侧片状增厚、压痛 1分,带下增多 1分,低热 1分,经期腹痛 1分,病程每增加 1年加 0.5分。以上累计积分 ≥15分者为重度,10~14分为中度,5~9分为轻度。
3.2参照中华人民共和国卫生部颁布的《中药新药临床研究指导原则》中的慢性盆腔炎的疗效标准拟定。①痊愈:治疗后下腹疼痛及腰骶胀痛等症状消失,妇科检查正常,B超检查均恢复正常,症状、体征积分为 0分,停药 1个月内未复发;②显效:治疗后下腹疼痛及腰骶胀痛等症状消失,妇科检查及 B超检查有明显改善 ,治疗前后积分降低 > 2 /3; ③有效:下腹疼痛及腰骶胀痛等症状减轻,妇科检查、B超检查均有改善 ,治疗后比治疗前积分减低 > 1 /3; ③无效:治疗后无改善。
4.治疗结果
4.1两组症状、体征积分比较 见表1。
表1 两组症状、体征积分比较(n=100)
与治疗前比较*P<0.01,#与对照组比较P<0.01
4.2两组疗效比较
值得指出的是,治疗组治愈率53.3%,明显高于对照组治愈率14.2%。
典型病例如下:
1.张某某,女,47岁,2年前人工流产后感染急性子宫内膜炎,后迁延为慢性盆腔炎。自觉腰痛,少腹坠痛,带下量多色黄,有时杂以血丝,气味腥臭,外阴瘙痒。间断应用抗生素,花红片等治疗1年余,效果不佳。查体:体温36.6℃,下腹压痛明显,子宫、双侧附件区较重。B超示:右侧输卵管积液,右下腹区可探及少量积液,肝、胆、胰、脾、肾、子宫未见异常。血常规检查正常。诊为:慢性盆腔炎(湿热下注证)。用本发明的胶囊剂治疗,每次口服6粒,每日三次。治疗28天,自觉上述症状完全消失。查体:体温36.5℃,腹平软,无压痛。B超示:肝、胆、胰、脾、肾、子宫、附件未见异常,腹腔未探积液。血常规检查正常。临床治愈。
2.宋某,女,37岁,自觉下腹冷痛,腰骶部疼痛,并有肛门坠胀感,带下量多色黄,气味臭,外阴瘙痒8月余。间断应用抗生素,妇炎康等治疗6月余,效果不佳。查体:舌淡红,苔黄腻,脉沉细。体温37.0℃,双侧附件及子宫区压痛明显,拒按,无反跳痛,双侧附件区可触及条索状物。B超示:肝、胆、胰、脾、肾、子宫、附件未见异常。血常规检查正常。诊为:慢性盆腔炎(湿热下注证)。用本发明的片剂治疗,每次口服6片,每日三次。治疗28天,自觉上述症状完全消失。查体:舌淡红,苔薄白,脉平。体温36.6℃,腹平软,无压痛,附件区条索状物消失。B超示:肝、胆、胰、脾、肾、子宫、附件未见异常。血常规检查正常。临床治愈。
以上所述,仅是本发明的部分较佳实施例,任何熟悉本领域的技术人员均可能利用上述阐述的技术方案加以修改或将其修改为等同的技术方案。因此,依据本发明的技术方案所进行的任何简单修改或等同置换,尽属于本发明要求保护的范围。
Claims (4)
1.一种治疗慢性盆腔炎的中药制剂,其特征是由以下重量份的中药制成:
山豆根50—100份、七叶一枝花60-90份、连翘50—90份、金银花50-70份、穿心莲50—70份、土茯苓50-70份、白头翁50-70份、乌蔹莓60-90份、秦皮50-70份、苍术50-70份、萆薢50-70份、赤芍50-70份、三七20-50份、肉桂30-70份。
2.根据权利要求1所述的治疗慢性盆腔炎的中药制剂,其特征是由以下重量份的中药制成:
山豆根50—70份、七叶一枝花70-90份、连翘50—70份、金银花50-70份、穿心莲50—70份、土茯苓50-70份、白头翁50-70份、乌蔹莓70-90份、秦皮50-70份、苍术50-70份、萆薢50-70份、赤芍60-70份、三七30-40份、肉桂40-70份。
3.根据权利要求1所述的治疗慢性盆腔炎的中药制剂,其特征是由以下重量份的中药制成:
山豆根70份、七叶一枝花70份、连翘90份、金银花70份、穿心莲70份、土茯苓70份、白头翁70份、乌蔹莓90份、秦皮70份、苍术70份、萆薢70份、赤芍70份、三七30份、肉桂70份。
4.一种如权利要求1-3中任一项所述的治疗慢性盆腔炎的中药制剂的制备方法,其特征是:包括以下步骤:
将上述重量份的药物分别粉碎成粗粉,将粉碎后药物混合,用水提取法常规提取两次,提取物减压干燥粉碎成细粉,加入淀粉或羧甲基淀粉钠5-15重量份为辅料,混匀制成0.5克/片的药片,或制成0.3克/粒胶囊备用。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610210209.XA CN105709137A (zh) | 2016-04-07 | 2016-04-07 | 一种治疗慢性盆腔炎的中药制剂 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610210209.XA CN105709137A (zh) | 2016-04-07 | 2016-04-07 | 一种治疗慢性盆腔炎的中药制剂 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105709137A true CN105709137A (zh) | 2016-06-29 |
Family
ID=56160628
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610210209.XA Pending CN105709137A (zh) | 2016-04-07 | 2016-04-07 | 一种治疗慢性盆腔炎的中药制剂 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105709137A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113855689A (zh) * | 2021-10-19 | 2021-12-31 | 黑龙江中医药大学 | 黄杞苷或其异构体在制备治疗子宫内膜异位症的药物中的用途 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101693057A (zh) * | 2009-10-19 | 2010-04-14 | 闫聿逊 | 一种治疗慢性盆腔炎的中药制剂 |
-
2016
- 2016-04-07 CN CN201610210209.XA patent/CN105709137A/zh active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101693057A (zh) * | 2009-10-19 | 2010-04-14 | 闫聿逊 | 一种治疗慢性盆腔炎的中药制剂 |
Non-Patent Citations (1)
Title |
---|
王光辉等: "妇炎胶囊治疗慢性盆腔炎 100 例疗效观察", 《山东中医杂志》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113855689A (zh) * | 2021-10-19 | 2021-12-31 | 黑龙江中医药大学 | 黄杞苷或其异构体在制备治疗子宫内膜异位症的药物中的用途 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102205026B (zh) | 一种治疗小儿慢性鼻窦炎的中药组合物及其制备方法 | |
CN104288701A (zh) | 一种治疗胆囊炎的中药组合物 | |
CN104147200B (zh) | 一种治疗妇科炎症的中药组合物及其制备方法 | |
CN104721749A (zh) | 一种治疗产褥感染后的中药清洗液及其制备方法 | |
CN101637552B (zh) | 一种防治慢性盆腔炎的中药组合物 | |
CN103751691A (zh) | 一种治疗湿疹的药物 | |
CN101129923A (zh) | 一种治疗子宫内膜炎的中药制剂 | |
CN102764394B (zh) | 治疗生殖性疾病的化毒和菌中药组合物及其制备方法 | |
CN105727209A (zh) | 一种用于产后护理的中药组合物 | |
CN102526620B (zh) | 一种治疗妇科炎症的中药组合物及应用 | |
CN101129927A (zh) | 一种治疗盆腔炎的中药组合物 | |
CN105709137A (zh) | 一种治疗慢性盆腔炎的中药制剂 | |
CN102727824A (zh) | 一种治疗阴部炎性疾病的中药 | |
CN101693057B (zh) | 一种治疗慢性盆腔炎的中药制剂 | |
CN104888117A (zh) | 一种治疗胆结石的中药及制备方法和用途 | |
CN104940752A (zh) | 一种治疗外阴溃疡的中药制剂及其制备方法 | |
CN104173791A (zh) | 一种用于治疗急性肾盂肾炎的中药 | |
CN108186785A (zh) | 一种治疗慢性盆腔炎的十二味中药组合物及其应用 | |
CN106310049A (zh) | 一种治疗肛肠疾病的中药颗粒剂及其制备方法 | |
CN104887933A (zh) | 用于治疗湿热瘀结型慢性盆腔炎的药物 | |
CN104857127A (zh) | 用于治疗湿热瘀结型慢性盆腔炎的内服药物 | |
CN105169111A (zh) | 一种用于治疗慢性荨麻疹的中药组合物及其应用 | |
CN103989885A (zh) | 一种治疗慢性盆腔炎中药 | |
CN104338086A (zh) | 一种治疗慢性子宫内膜炎的中药灌肠剂及其制备方法 | |
CN104547943A (zh) | 治疗产褥热的中药组合物及制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160629 |
|
WD01 | Invention patent application deemed withdrawn after publication |