CN105708947A - Traditional Chinese medicine composition containing argy wormwood leaves and used for treating urticaria and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition containing argy wormwood leaves and used for treating urticaria and preparation method of traditional Chinese medicine composition Download PDFInfo
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- CN105708947A CN105708947A CN201610206217.7A CN201610206217A CN105708947A CN 105708947 A CN105708947 A CN 105708947A CN 201610206217 A CN201610206217 A CN 201610206217A CN 105708947 A CN105708947 A CN 105708947A
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Abstract
The invention belongs to the technical field of traditional Chinese medicines and discloses traditional Chinese medicine composition containing argy wormwood leaves and used for treating urticaria and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises traditional Chinese medicinal materials in parts by weight as follows: 19-26 parts of argy wormwood leaves, 18-23 parts of divaricate saposhnikovia roots, 16-23 parts of flax, 12-19 parts of fineleaf schizonepeta herbs, 12-18 parts of cicada sloughs, 11-18 parts of vietnamese sophora roots, 9-15 parts of ephedra herbs, 7-12 parts of paniculate swallowwort roots, 6-12 parts of dandelions, 7-13 parts of longan shells and 3-12 parts of liquorice. Selected traditional Chinese medicine ingredients are stable, the treatment is safe, the application range is wide, and the traditional Chinese medicine composition has the advantages that the composition has good curative effect on treatment of urticarial, takes effect quickly, is safe to use, has no side effects and the like.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of urticaria containing Folium Artemisiae Argyi and preparation method thereof.
Background technology
Urticaria is commonly called as welt, rubella wheal, is that the relatively conventional anaphylactic disease of skin mucosa, the mainly temporary vascular permeability of skin mucosa increase
The localized edema added and occur.Urticaria can accompany by the most violent pruritus and scratch.The erythra performance of this disease contacts plant Herba Urticae Cannabinae just as people,
The skin lesion caused is similar, therefore is called urticaria.Urticaria occur without significantly race and sex difference, each age level all can be sent out
Raw.
The inducement of urticaria is a lot, the common cause of disease have food (as fish, shrimp, eggs, milk or other be imbued with protide food), medicine is (such as green grass or young crops
Mycin, furazolidone, serum, vaccine etc.), antibacterial (amygdala inflammation, nasosinustis, chronic appendicitis etc.), virus (such as hepatitis, upper breathing
Road sense etc.), parasite and fungal infection, Nervous and Mental Factors (as nervous), animal and plant factors are (as sucked the scurf of animal, feather or flower
Powder etc.), and physics and chemical factor (as cold and hot, daylight, friction and pressure, mechanical irritation or some chemical substance) and suffer from some skin or complete
Body disease, endocrinopathy etc., all can cause the generation of urticaria.
Classifying by the course of disease, urticaria can be divided into acute and chronic, and the former can cure through a couple of days or several weeks, the latter's then recurrent exerbation periods of months.Acute
Urticaria is often acute attack, whole body pruritus, welt, erythra, and hyperpyrexia, severe patient blood pressure drops can be accompanied even to suffer a shock, the course of disease 1～nature in 2 weeks
Recovery from illness.The morbidity of chronic urticaria accounts for the 2/3 of urticaria, and welt happens over and over again, time many time few, the most for years do not heal, up to more than 2 months,
Most patients can not find the cause of disease.
Western medical treatment includes injecting calcium preparation, Placenta Hominis histamine, histaglobin, vein closing or chloroquine, reserpine, aminophylline, aminocaproic acid being administered orally
Deng medicine, there is certain curative effect, but toxic and side effects is bigger.
The traditional Chinese medical science is thought, is weak to because composing official report, from the beginning of for affection by exopathogenic cold-wind or wind heat visitor's table, causes disharmony of nutrient QI with defensive QI, and pathogen is strongly fragrant in space between skin and muscles, must not thoroughly reach outward, interior
Must not catharsis, therefore see welt, wind being YANG-pathogen benefaction and number becomes, therefore onset is hurried, and flickering, skin lesion appearing without definite location, pathogenic heat are strongly fragrant in blood system, and heat in blood is raw
Wind or pathogenic heat are burnt cloudy liquid, and wind syndrome due to blood-deficiency then makes Relapse rate show effect, and delay is difficult heals.Or because of improper diet, dysfunction of the spleen in transportation, the stagnation of QI in inner or in have
Malnutrition due to parasitic infestation, is caused primary disease again by ailment said due to cold or exposure.In a word, caused by dialectical genus wind and cold, wind heat, heat in blood, insufficiency of the spleen, blood deficiency；Clinically will be according to the body of patient
Matter and tongue arteries and veins disease, because people is dialectical, can not arrest and intend into side, should use flexibly.
Chinese invention patent application 201510331994.X relates to a kind of Chinese medicine treating urticaria, and this Chinese medicine includes in following parts by weight
Medical material: Fructus Forsythiae 11-17 part, Folium Rhodomyrti 9-12 part, Flos Chrysanthemi Indici 10-16 part, Lindera angustifolia Cheng 8-13 part, Herba Sambuci Chiensis 6-12 part, Radix seu Folium Alchorneae trewioidis 10-15 part, Fructus Kochiae
Sub-7-11 part, Citrus aurantium L. var. amara Engl. 9-16 part, Radix berchemiae lineatae 8-12 part, Herba Ephedrae 9-13 part, Fructus Viburni Foetidi 11-15 part, Flos Celosiae Cristatae 9-17 part, Zaocys 6-10 part, scape
It 12-18 part, Chimonanthusn itens Oliv. 10-16 part, Cortex Hibisci 9-15 part.Having certain therapeutic effect for urticaria, but raw material is too much, preparation technology is more numerous
Superfluous, not easy exploiting.
Summary of the invention
At present, treatment urticaria medicine mostly treatment cycle length, take effect slow, can not fundamentally cure patient disease.Present invention aims to invention
A kind of Chinese medicine composition, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, reduces toxic and side effects, improves therapeutic effect.
For realizing the purpose of the present invention, technical solution of the present invention is as follows:
The Chinese medicine composition of the treatment urticaria that the present invention contains Folium Artemisiae Argyi includes the Chinese crude drug of following weight portion:
Folium Artemisiae Argyi 19-26 part, Radix Saposhnikoviae 18-23 part, linum 16-23 part, Herba Schizonepetae 12-19 part, Periostracum Cicadae 12-18 part, Radix Sophorae Tonkinensis 11-18 part, Herba Ephedrae
9-15 part, Radix Cynanchi Paniculati 7-12 part, Herba Taraxaci 6-12 part, Pericarpium Longan 7-13 part and Radix Glycyrrhizae 3-12 part.
Preferably, the Chinese medicine composition of the described treatment urticaria containing Folium Artemisiae Argyi includes the Chinese crude drug of following weight portion:
Folium Artemisiae Argyi 19 parts, Radix Saposhnikoviae 18 parts, linum 16 parts, Herba Schizonepetae 12 parts, Periostracum Cicadae 12 parts, Radix Sophorae Tonkinensis 11 parts, 9 parts of Herba Ephedrae, Radix Cynanchi Paniculati 7 parts,
Herba Taraxaci 6 parts, Pericarpium Longan 7 parts and 3 parts of Radix Glycyrrhizae.
It is further preferred that the Chinese medicine composition of the described treatment urticaria containing Folium Artemisiae Argyi includes the Chinese crude drug of following weight portion:
Folium Artemisiae Argyi 26 parts, Radix Saposhnikoviae 23 parts, linum 23 parts, Herba Schizonepetae 19 parts, Periostracum Cicadae 18 parts, Radix Sophorae Tonkinensis 18 parts, 15 parts of Herba Ephedrae, Radix Cynanchi Paniculati 12
Part, Herba Taraxaci 12 parts, Pericarpium Longan 13 parts and 12 parts of Radix Glycyrrhizae.
It is further preferred that the Chinese medicine composition of the described treatment urticaria containing Folium Artemisiae Argyi includes the Chinese crude drug of following weight portion:
Folium Artemisiae Argyi 25 parts, Radix Saposhnikoviae 23 parts, linum 21 parts, Herba Schizonepetae 18 parts, Periostracum Cicadae 16 parts, Radix Sophorae Tonkinensis 15 parts, 12 parts of Herba Ephedrae, Radix Cynanchi Paniculati 10
Part, Herba Taraxaci 10 parts, Pericarpium Longan 9 parts and 5 parts of Radix Glycyrrhizae.
The preparation method that above-mentioned Chinese prescription is made finished product Chinese medicine composition is following steps:
Step 1, weigh each taste raw medicinal material in proportion；
Step 2, Folium Artemisiae Argyi, Radix Saposhnikoviae, linum, Herba Schizonepetae, Periostracum Cicadae, Radix Sophorae Tonkinensis, Herba Ephedrae, Radix Cynanchi Paniculati, Herba Taraxaci, Pericarpium Longan and Radix Glycyrrhizae are gone respectively
Impurity, cleans, and dries, is ground into coarse powder；
Step 3, coarse powder Folium Artemisiae Argyi, Radix Saposhnikoviae, Periostracum Cicadae, Radix Sophorae Tonkinensis, Radix Cynanchi Paniculati, Herba Taraxaci, Pericarpium Longan and Radix Glycyrrhizae prepared mix, and are fabricated to do
Medicated bag, adds the purified water of 6-12 times of medical material weight, decocts 2-3 time, each 2-4 hour, pulls medicated bag out, filters, merging filtrate, is condensed into
When 55-65 DEG C, relative density is the water extracting liquid of 1.15-1.20, standby；
Step 4, the coarse powder mixing that linum, Herba Schizonepetae and Herba Ephedrae will be made to prepare, be fabricated to dry medicated bag, add the ethanol of 6-12 times of medical material weight 70-90%,
Reflux, extract, 2-3 time, each 5-8 hour, merges alcohol extract, decompression distillation, removes ethanol, and filtrate is concentrated into relative density under 55-65 DEG C of environment
For the alcohol extraction concentrated solution of 1.15-1.20, standby；
Step 5, step 3 gained water extracting liquid and step 4 gained alcohol extraction concentrated solution being merged, being concentrated into relative density under 70-80 DEG C of environment is
1.25-1.36, is Chinese medical concrete；
Step 6, in Chinese medical concrete, add suitable adjuvant, make dosage form needed for clinic with modern Chinese medicine conventional formulation technique, such as capsule,
Tablet, powder or decoction.
The source of Chinese crude drug, nature and flavor used by Chinese prescription of the present invention, return through and effect:
Folium Artemisiae Argyi: this product is the dried leaves of feverfew Chinese mugwort.Acrid in the mouth, hardship, warm in nature；Return liver,spleen,kidney warp；Dispersing cold for relieving pain, warming the meridian for stopping bleeding.
Radix Saposhnikoviae: this product is the dry root of umbelliferae Saposhnikovia divaricata.Taste acrid, sweet, warm；Return bladder, liver, spleen channel；Inducing diaphoresis to dispel wind, wins wet, relieving convulsion.
Linum: this product is the mature seed of Pedaliaceae plant linum.Sweet in the mouth, property is put down；Return lung, spleen, liver, kidney channel；Moisturize laxation, nourishing the liver and kidney.
Herba Schizonepetae: this product is the dry aerial parts of labiate Herba Schizonepetae.Acrid in the mouth, slightly warm in nature；Return lung, Liver Channel；Induce sweat scattered wind, rash.
Periostracum Cicadae: exuviae shell when this product is the larva emergence of cicada Cryptotympana atrata Fabr..Sweet in the mouth, cold in nature；Return lung, Liver Channel；Scattered wind heat extraction, sore-throat relieving,
Rash, nebula removing, spasmolytic.
Radix Sophorae Tonkinensis: this product is the little Radix Sophorae Tonkinensis of Menispermaceae, is used as medicine with root.Bitter in the mouth, cold in nature；Return lung, the heart, large intestine channel；Heat-clearing and toxic substances removing, pain relieving parasite killing.
Herba Ephedrae: this product is the dry herb stem of Ephedraceae plant plait Herba Ephedrae, epheday intermedia or ephedra equisetina.Acrid in the mouth, micro-hardship, warm in nature；Return lung, bladder
Warp；Diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.
Radix Cynanchi Paniculati: this product is the dry root and rhizome of trailing plants section Cynanchum plant Radix Cynanchi Paniculati.Acrid in the mouth, warm in nature；Return liver, stomach warp；Dispel the wind removing dampness,
Antalgesic-antipruritic.
Herba Taraxaci: this product is feverfew Herba Taraxaci, alkali ground Herba Taraxaci or the dry herb belonging to several plants together.Bitter in the mouth, sweet, cold in nature；Return liver,
Stomach warp；Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.
Pericarpium Longan: this product is the peel without being loyal to section plant Arillus Longan.Sweet in the mouth, warm in nature；Return lung meridian；Dispel the wind, removing toxic substances, sore, granulation promoting.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down；GUIXIN, lung, spleen, stomach warp；Mend
Spleen QI invigorating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The compatibility analysis of Chinese prescription of the present invention:
Chinese prescription of the present invention is with Folium Artemisiae Argyi, Radix Saposhnikoviae, linum as monarch drug, inducing diaphoresis to dispel wind, nourishing the liver and kidney；With Herba Schizonepetae, Periostracum Cicadae, Radix Sophorae Tonkinensis as ministerial drug,
Heat extraction rash, inducing diuresis to remove edema；With Herba Ephedrae, Radix Cynanchi Paniculati, Herba Taraxaci, Pericarpium Longan as adjuvant drug, antalgesic-antipruritic, heat-clearing and toxic substances removing；With Radix Glycyrrhizae for making medicine,
The coordinating the actions of various ingredients in a prescription property of medicine, all medicines coordinate, complement each other, synergism, play removing toxic substances sore, function of spleen and stomach regulating, effects such as scattered wind of inducing sweat altogether, to urticaria
There is the most significant curative effect.
Compared with prior art, beneficial effect of the present invention is summarized as follows:
Chinese medicine composition the most of the present invention selects Chinese medicine material to be prepared from, and stable components treats safety, and range of applicability is wide, in addition in the present invention
Medicine prescription obtains according to clinical empirical summary for many years, has removing toxic substances sore, function of spleen and stomach regulating, effects such as scattered wind of inducing sweat；
2. zoopery shows, Chinese medicine composition of the present invention, compared to the current Western medicine treating urticaria on the market, has and more preferably alleviates urticaria
The curative effect of symptom, can significantly reduce the content of mice serum histamine, thus effectively treat urticaria；
Chinese medicine composition preparation technology the most of the present invention is simple and easy to do, preparation drug effect safety and stability, application easy to spread.
Detailed description of the invention
Below will by specific embodiment, the present invention is described further, it will be understood by those skilled in the art that the present invention in addition to following example also
Other similar changing can be made and obtain similar result without deviating from present disclosure and scope.
Embodiment 1
The Chinese medicine composition of the embodiment of the present invention 1 treatment urticaria containing Folium Artemisiae Argyi includes the Chinese crude drug of following weight portion:
Folium Artemisiae Argyi 19 parts, Radix Saposhnikoviae 18 parts, linum 16 parts, Herba Schizonepetae 12 parts, Periostracum Cicadae 12 parts, Radix Sophorae Tonkinensis 11 parts, 9 parts of Herba Ephedrae, Radix Cynanchi Paniculati 7 parts,
Herba Taraxaci 6 parts, Pericarpium Longan 7 parts and 3 parts of Radix Glycyrrhizae；
Preparation method is as follows:
Step 1, weigh each taste raw medicinal material in proportion；
Step 2, Folium Artemisiae Argyi, Radix Saposhnikoviae, linum, Herba Schizonepetae, Periostracum Cicadae, Radix Sophorae Tonkinensis, Herba Ephedrae, Radix Cynanchi Paniculati, Herba Taraxaci, Pericarpium Longan and Radix Glycyrrhizae are gone respectively
Impurity, cleans, and dries, is ground into coarse powder；
Step 3, coarse powder Folium Artemisiae Argyi, Radix Saposhnikoviae, Periostracum Cicadae, Radix Sophorae Tonkinensis, Radix Cynanchi Paniculati, Herba Taraxaci, Pericarpium Longan and Radix Glycyrrhizae prepared mix, and are fabricated to do
Medicated bag, adds the purified water of 6 times of medical material weight, decocts 2 times, each 2 hours, pull medicated bag out, filters, and merging filtrate, when being condensed into 55 DEG C
Relative density is the water extracting liquid of 1.15, standby；
Step 4, the coarse powder mixing that linum, Herba Schizonepetae and Herba Ephedrae will be made to prepare, be fabricated to dry medicated bag, add the ethanol of 6 times of medical material weight 70%, backflow
Extracting 2 times, each 5 hours, merge alcohol extract, decompression distillation, remove ethanol, it is 1.15 that filtrate is concentrated into relative density under 55 DEG C of environment
Alcohol extraction concentrated solution, standby；
Step 5, step 3 gained water extracting liquid and step 4 gained alcohol extraction concentrated solution being merged, being concentrated into relative density under 70 DEG C of environment is 1.25,
It is Chinese medical concrete；
Step 6, in Chinese medical concrete, add suitable adjuvant, make granule with modern Chinese medicine conventional formulation technique.
Embodiment 2
The Chinese medicine composition of the embodiment of the present invention 2 treatment urticaria containing Folium Artemisiae Argyi includes the Chinese crude drug of following weight portion:
Folium Artemisiae Argyi 26 parts, Radix Saposhnikoviae 23 parts, linum 23 parts, Herba Schizonepetae 19 parts, Periostracum Cicadae 18 parts, Radix Sophorae Tonkinensis 18 parts, 15 parts of Herba Ephedrae, Radix Cynanchi Paniculati 12
Part, Herba Taraxaci 12 parts, Pericarpium Longan 13 parts and 12 parts of Radix Glycyrrhizae；
Preparation method is as follows:
Step 1, weigh each taste raw medicinal material in proportion；
Step 2, Folium Artemisiae Argyi, Radix Saposhnikoviae, linum, Herba Schizonepetae, Periostracum Cicadae, Radix Sophorae Tonkinensis, Herba Ephedrae, Radix Cynanchi Paniculati, Herba Taraxaci, Pericarpium Longan and Radix Glycyrrhizae are gone respectively
Impurity, cleans, and dries, is ground into coarse powder；
Step 3, coarse powder Folium Artemisiae Argyi, Radix Saposhnikoviae, Periostracum Cicadae, Radix Sophorae Tonkinensis, Radix Cynanchi Paniculati, Herba Taraxaci, Pericarpium Longan and Radix Glycyrrhizae prepared mix, and are fabricated to do
Medicated bag, adds the purified water of 12 times of medical material weight, decocts 3 times, each 4 hours, pull medicated bag out, filters, merging filtrate, is condensed into 65 DEG C
Time relative density be the water extracting liquid of 1.20, standby；
Step 4, the coarse powder mixing that linum, Herba Schizonepetae and Herba Ephedrae will be made to prepare, be fabricated to dry medicated bag, add the ethanol of 12 times of medical material weight 90%, return
Stream extracts 3 times, each 8 hours, merges alcohol extract, decompression distillation, removes ethanol, and it is 1.20 that filtrate is concentrated into relative density under 65 DEG C of environment
Alcohol extraction concentrated solution, standby；
Step 5, step 3 gained water extracting liquid and step 4 gained alcohol extraction concentrated solution being merged, being concentrated into relative density under 80 DEG C of environment is 1.36,
It is Chinese medical concrete；
Step 6, in Chinese medical concrete, add suitable adjuvant, make powder with modern Chinese medicine conventional formulation technique.
Embodiment 3
The Chinese medicine composition of the embodiment of the present invention 3 treatment urticaria containing Folium Artemisiae Argyi includes the Chinese crude drug of following weight portion:
Folium Artemisiae Argyi 25 parts, Radix Saposhnikoviae 23 parts, linum 21 parts, Herba Schizonepetae 18 parts, Periostracum Cicadae 16 parts, Radix Sophorae Tonkinensis 15 parts, 12 parts of Herba Ephedrae, Radix Cynanchi Paniculati 10
Part, Herba Taraxaci 10 parts, Pericarpium Longan 9 parts and 5 parts of Radix Glycyrrhizae；
Step 1, weigh each taste raw medicinal material in proportion；
Step 2, Folium Artemisiae Argyi, Radix Saposhnikoviae, linum, Herba Schizonepetae, Periostracum Cicadae, Radix Sophorae Tonkinensis, Herba Ephedrae, Radix Cynanchi Paniculati, Herba Taraxaci, Pericarpium Longan and Radix Glycyrrhizae are gone respectively
Impurity, cleans, and dries, is ground into coarse powder；
Step 3, coarse powder Folium Artemisiae Argyi, Radix Saposhnikoviae, Periostracum Cicadae, Radix Sophorae Tonkinensis, Radix Cynanchi Paniculati, Herba Taraxaci, Pericarpium Longan and Radix Glycyrrhizae prepared mix, and are fabricated to do
Medicated bag, adds the purified water of 8 times of medical material weight, decocts 3 times, each 3 hours, pull medicated bag out, filters, and merging filtrate, when being condensed into 65 DEG C
Relative density is the water extracting liquid of 1.20, standby；
Step 4, the coarse powder mixing that linum, Herba Schizonepetae and Herba Ephedrae will be made to prepare, be fabricated to dry medicated bag, add the ethanol of 8 times of medical material weight 85%, backflow
Extracting 3 times, each 6 hours, merge alcohol extract, decompression distillation, remove ethanol, it is 1.20 that filtrate is concentrated into relative density under 65 DEG C of environment
Alcohol extraction concentrated solution, standby；
Step 5, step 3 gained water extracting liquid and step 4 gained alcohol extraction concentrated solution being merged, being concentrated into relative density under 80 DEG C of environment is 1.36,
It is Chinese medical concrete；
Step 6, in Chinese medical concrete, add suitable adjuvant, make tablet with modern Chinese medicine conventional formulation technique.
Embodiment 4
The Chinese medicine composition of the embodiment of the present invention 4 treatment urticaria containing Folium Artemisiae Argyi includes the Chinese crude drug of following weight portion:
Folium Artemisiae Argyi 25 parts, Radix Saposhnikoviae 23 parts, linum 21 parts, Herba Schizonepetae 18 parts, Periostracum Cicadae 16 parts, Radix Sophorae Tonkinensis 15 parts, 12 parts of Herba Ephedrae, Radix Cynanchi Paniculati 10
Part, Herba Taraxaci 10 parts, Pericarpium Longan 9 parts and 5 parts of Radix Glycyrrhizae；
Preparation method such as embodiment 1.
Chinese medicine composition pharmacodynamic study of the present invention:
Test example one, the Chinese medicine composition of the present invention impact on mice urticaria
1, experiment purpose and method
According to the requirement of " new Chinese medicine pharmaceutical research guide ", study the Chinese medicine composition of the present invention Pharmacodynamics in treatment urticaria.Take
The embodiment of the present invention one to three gained Chinese medicine composition, observes its impact on QI and blood deficiency urticaria mouse model.
Method: choose 70 KM QI and blood deficiency urticaria model mices and 10 normal KM mices (are purchased from Henan rich biological plasticized science and technology
Company limited；Mus 6-8 in age week；Body weight is 15-30g), female mice is all without pregnant.Randomly select 50 model mices and be divided into 5 groups, be respectively
Model group, positive controls, embodiment 1-3 group, often group 10；10 normal KM mices are Normal group.By embodiment of the present invention 1-3
The Chinese medicine composition prepared, adds water or directly adds water after removing shell, furnishing scattered paste shape, and gastric infusion is in embodiment 1-3 group respectively, is administered
Dosage is 30mg/Kg, every day 1 time, continuous 10 days；Positive controls institute drug is that (Xian-Janssen Pharmaceutical Ltd. is raw for loratadine tablet
Produce；Traditional Chinese medicines quasi-word H20070030), add water furnishing scattered paste shape, gastric infusion, and dosage is 30mg/Kg, every day 1 time, continuous 10 days；
Normal group, model group give the normal saline of same volume, and administering mode is the same.
Remaining 20 model mices and divide equally two groups, respectively the height of curative effect more significantly embodiment and low dose group, dosage is respectively
60mg/Kg, 15mg/Kg, the dosage 30mg/Kg used by the embodiment described above group is middle dosage group, and administering mode is the same.
Record mouse systemic pruritus reaction fore paw scratch head, after grab dawn trunk, mouth to sting each position of whole body be that scabies is held in both hands after indication terminates, little rathole
Socket of the eye takes blood, and 3000r/min is centrifuged 10 minutes and separates serum, uses Elisa method to measure every animal serum histamine levels.Collection of specimens is in experimental period
Between, weigh in weekly once.
Statistical procedures test data all uses mean ± standard deviation to represent, group difference significance uses one factor analysis of variance to compare, P
＜ 0.05 is for there being significant difference, and P ＜ 0.01 is for there being pole significant difference.SPSS19.0 statistical software is used to carry out data process.
2, experimental result
The impact on mice serum histamine of table 1 Chinese medicine composition of the present invention
| Group | Dosage (mg/Kg) | Quantity | Serum histamine (ng/ml) |
| Normal group | - | 10 | 6.54±0.94 |
| Model group | - | 10 | 10.48±1.72** |
| Positive controls | 30 | 10 | 8.10±1.05▲ |
| Embodiment 1 group | 30 | 10 | 8.06±0.98▲ |
| Embodiment 2 groups | 30 | 10 | 7.98±1.18▲ |
| Embodiment 3 groups | 30 | 10 | 7.34±0.56▲▲ |
Note: compare with Normal group,**P ＜ 0.01；Compare with model group,▲P ＜ 0.05,▲▲P ＜ 0.01.
The impact on mice serum histamine of the table 2 embodiment 3 Chinese medicine composition various dose
| Group | Dosage (mg/Kg) | Quantity | Serum histamine (ng/ml) |
| Model group | - | 10 | 10.48±1.72 |
| Positive controls | 30 | 10 | 8.10±1.05▲ |
| High dose group | 60 | 10 | 6.52±0.97▲▲# |
| Middle dosage group | 30 | 10 | 7.34±0.56▲▲ |
| Low dose group | 15 | 10 | 8.22±1.00▲ |
Note: compare with model group,▲P ＜ 0.05,▲▲P ＜ 0.01；Compare with positive controls,#P ＜ 0.05.
3, conclusion
This experiment is by the research embodiment of the present invention 1-3 gained Chinese medicine composition impact on the serum group amine content of QI and blood deficiency urticaria model mice
Judge the Chinese medicine composition of the present invention effect in terms for the treatment of urticaria.Each administration group is administered for continuous 10 days, and none is dead for mice, puts to death mice
Anatomic observation does not finds toxic reaction except remaining each internal organs of pulmonary, and Mouse Weight is also without significant change.
The words and deeds factor and the media such as the infection center link of urticaria is mastocyte and basophilic granulocyte retting conditions, release histamine, cause a series of
Pathophysiological change.Table 1 result shows, Chinese medicine composition of the present invention can obviously reduce the serum group amine content (P ＜ 0.05) of mice, therefore, originally
Invention Chinese medicine composition has the effect of anti-urticaria, the wherein best results of embodiment 3 Chinese medicine composition.Therefore, continued by different dosing dosage
The anti-urticaria effect of continuous research embodiment 3 Chinese medicine composition.
As shown in Table 2, compared with model group, the serum histamine of embodiment 3 high, medium and low dosage group significantly reduces (P ＜ 0.05)；Right with the positive
Comparing according to group, embodiment 3 high dose group reduces serum group amine content and has significant difference (P ＜ 0.05), it follows that embodiment 3 high dose group
Therapeutic effect optimal.Result above shows, three dosage groups of the embodiment of the present invention 3 Chinese medicine composition all have notable alleviation urticaria effect, especially
Better with high dose, and there is certain safety, there is the effect of good treatment urticaria.
Owing to describing the present invention by above preferred embodiment, in the spirit and/or scope of the present invention, any replacement for the present invention/
Or combination implement the present invention, will be apparent from for a person skilled in the art, and be included among the present invention.
Claims (7)
1. the Chinese medicine composition of the treatment urticaria containing Folium Artemisiae Argyi, it is characterised in that described Chinese medicine composition includes the Chinese medicine of following weight portion
Material:
Folium Artemisiae Argyi 19-26 part, Radix Saposhnikoviae 18-23 part, linum 16-23 part, Herba Schizonepetae 12-19 part, Periostracum Cicadae 12-18 part, Radix Sophorae Tonkinensis 11-18 part, Herba Ephedrae
9-15 part, Radix Cynanchi Paniculati 7-12 part, Herba Taraxaci 6-12 part, Pericarpium Longan 7-13 part and Radix Glycyrrhizae 3-12 part.
The Chinese medicine composition of the treatment urticaria containing Folium Artemisiae Argyi the most according to claim 1, it is characterised in that described Chinese medicine composition includes
The Chinese crude drug of following weight portion:
Folium Artemisiae Argyi 19 parts, Radix Saposhnikoviae 18 parts, linum 16 parts, Herba Schizonepetae 12 parts, Periostracum Cicadae 12 parts, Radix Sophorae Tonkinensis 11 parts, 9 parts of Herba Ephedrae, Radix Cynanchi Paniculati 7 parts,
Herba Taraxaci 6 parts, Pericarpium Longan 7 parts and 3 parts of Radix Glycyrrhizae.
The Chinese medicine composition of the treatment urticaria containing Folium Artemisiae Argyi the most according to claim 1, it is characterised in that described Chinese medicine composition includes
The Chinese crude drug of following weight portion:
Folium Artemisiae Argyi 26 parts, Radix Saposhnikoviae 23 parts, linum 23 parts, Herba Schizonepetae 19 parts, Periostracum Cicadae 18 parts, Radix Sophorae Tonkinensis 18 parts, 15 parts of Herba Ephedrae, Radix Cynanchi Paniculati 12
Part, Herba Taraxaci 12 parts, Pericarpium Longan 13 parts and 12 parts of Radix Glycyrrhizae.
The Chinese medicine composition of the treatment urticaria containing Folium Artemisiae Argyi the most according to claim 1, it is characterised in that described Chinese medicine composition includes
The Chinese crude drug of following weight portion:
Folium Artemisiae Argyi 25 parts, Radix Saposhnikoviae 23 parts, linum 21 parts, Herba Schizonepetae 18 parts, Periostracum Cicadae 16 parts, Radix Sophorae Tonkinensis 15 parts, 12 parts of Herba Ephedrae, Radix Cynanchi Paniculati 10
Part, Herba Taraxaci 10 parts, Pericarpium Longan 9 parts and 5 parts of Radix Glycyrrhizae.
5. according to the Chinese medicine composition of the arbitrary described treatment urticaria containing Folium Artemisiae Argyi of claim 1-4, it is characterised in that described Chinese medicine composition
For capsule, tablet, powder or decoction.
6. according to the Chinese medicine composition of the arbitrary described treatment urticaria containing Folium Artemisiae Argyi of claim 1-4, it is characterised in that described Chinese medicine composition
Preparation method comprise the following steps:
Step 1, weigh each taste raw medicinal material in proportion；
Step 2, Folium Artemisiae Argyi, Radix Saposhnikoviae, linum, Herba Schizonepetae, Periostracum Cicadae, Radix Sophorae Tonkinensis, Herba Ephedrae, Radix Cynanchi Paniculati, Herba Taraxaci, Pericarpium Longan and Radix Glycyrrhizae are gone respectively
Impurity, cleans, and dries, is ground into coarse powder；
Step 3, coarse powder Folium Artemisiae Argyi, Radix Saposhnikoviae, Periostracum Cicadae, Radix Sophorae Tonkinensis, Radix Cynanchi Paniculati, Herba Taraxaci, Pericarpium Longan and Radix Glycyrrhizae prepared mix, and are fabricated to do
Medicated bag, adds the purified water of 6-12 times of medical material weight, decocts 2-3 time, each 2-4 hour, pulls medicated bag out, filters, merging filtrate, is condensed into
When 55-65 DEG C, relative density is the water extracting liquid of 1.15-1.20, standby；
Step 4, the coarse powder mixing that linum, Herba Schizonepetae and Herba Ephedrae will be made to prepare, be fabricated to dry medicated bag, add the ethanol of 6-12 times of medical material weight 70-90%,
Reflux, extract, 2-3 time, each 5-8 hour, merges alcohol extract, decompression distillation, removes ethanol, and filtrate is concentrated into relative density under 55-65 DEG C of environment
For the alcohol extraction concentrated solution of 1.15-1.20, standby；
Step 5, step 3 gained water extracting liquid and step 4 gained alcohol extraction concentrated solution being merged, being concentrated into relative density under 70-80 DEG C of environment is
1.25-1.36, is Chinese medical concrete；
Step 6, Chinese medical concrete is added adjuvant make finished product Chinese medicine composition.
7. the method for the Chinese medicine composition of the treatment urticaria containing Folium Artemisiae Argyi prepared as described in claim 1-6 is arbitrary, it is characterised in that bag
Include following steps:
Step 1, weigh each taste raw medicinal material in proportion；
Step 2, Folium Artemisiae Argyi, Radix Saposhnikoviae, linum, Herba Schizonepetae, Periostracum Cicadae, Radix Sophorae Tonkinensis, Herba Ephedrae, Radix Cynanchi Paniculati, Herba Taraxaci, Pericarpium Longan and Radix Glycyrrhizae are gone respectively
Impurity, cleans, and dries, is ground into coarse powder；
Step 3, coarse powder Folium Artemisiae Argyi, Radix Saposhnikoviae, Periostracum Cicadae, Radix Sophorae Tonkinensis, Radix Cynanchi Paniculati, Herba Taraxaci, Pericarpium Longan and Radix Glycyrrhizae prepared mix, and are fabricated to do
Medicated bag, adds the purified water of 6-12 times of medical material weight, decocts 2-3 time, each 2-4 hour, pulls medicated bag out, filters, merging filtrate, is condensed into
When 55-65 DEG C, relative density is the water extracting liquid of 1.15-1.20, standby；
Step 4, the coarse powder mixing that linum, Herba Schizonepetae and Herba Ephedrae will be made to prepare, be fabricated to dry medicated bag, add the ethanol of 6-12 times of medical material weight 70-90%,
Reflux, extract, 2-3 time, each 5-8 hour, merges alcohol extract, decompression distillation, removes ethanol, and filtrate is concentrated into relative density under 55-65 DEG C of environment
For the alcohol extraction concentrated solution of 1.15-1.20, standby；
Step 5, step 3 gained water extracting liquid and step 4 gained alcohol extraction concentrated solution being merged, being concentrated into relative density under 70-80 DEG C of environment is
1.25-1.36, is Chinese medical concrete；
Step 6, Chinese medical concrete is added adjuvant make finished product Chinese medicine composition.
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