CN105688224A - Preparation method of auxiliary agent foaming liquid of traditional Chinese medicine preparation and preparation method of traditional Chinese medicine preparation - Google Patents
Preparation method of auxiliary agent foaming liquid of traditional Chinese medicine preparation and preparation method of traditional Chinese medicine preparation Download PDFInfo
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Abstract
The invention discloses a preparation method of an auxiliary agent foaming liquid of a traditional Chinese medicine preparation and a preparation method of the traditional Chinese medicine preparation. The preparation method of the auxiliary agent foaming liquid comprises steps as follows: a culture medium containing sugar or containing protein feed and sugar is added to daily drinking water to serve as a culture solution; a microorganism starter culture is added when the culture solution is at the normal temperature, and the mixture is uniformly stirred and foamed; the foaming liquid is formed when the PH value of the culture solution ranges from 4.5 to 6.5 after foaming and is used for soaking prepared traditional Chinese medicine powder for 12 hours or longer, so that effective ingredients in a traditional Chinese medicine can be sufficiently dissolved, the medicinal curative effect is improved, the medicine utilization rate is increased, traditional Chinese medicines are saved, and the dosage is reduced.
Description
Technical field
The present invention relates to Chinese drug preparation manufacture field, especially relate to the preparation method of attached dose of expanding foam solution of a kind of Chinese medicine preparation and the preparation method of Chinese medicine preparation。
Background technology
The Chinese medicine preparation that tcm prescription is conventional is Chinese medicine decoction, and Chinese medicine decoction is liquid compound dispersing agent, be China apply the earliest, maximum a kind of dosage forms, current tcm clinical practice still widely uses。Chinese medicine decoction why thousands of year adopts so far, is because this dosage form prescription flexible, it is possible to fully adapt to the needs of tcm treatment according to syndrome differentiation, and it is fast to have curative effect, easily absorbs, act on several big features such as strong, adapt to the needs of tcm treatment according to syndrome differentiation。
But the method for making of Chinese medicine decoction generally by Chinese medicine with water for solvent, the direct decocting method of high temperature is adopted to be prepared from, this method is prepared Chinese medicine preparation and must be decocted together by Chinese medicine simultaneously, Effective Component of Chinese Medicine is utilized very poor, and the easy moldy metamorphism of Chinese medicine preparation being achieved in that and should not deposit for a long time, flavour of a drug are pained, dose is big；Chinese medicine includes pungent sweet bitter one-tenth and the puckery various tastes of raw meat, and Chinese medicinal decoction bitterness is tasty, and it is poor that decocting method Effective Component of Chinese Medicine utilizes, so to measure greatly with Chinese medicine, soup is many, has and drinks Chinese medicine and to fill saying of intestinal。
Summary of the invention
The preparation method that the invention provides the preparation method of attached dose of expanding foam solution of a kind of Chinese medicine preparation and Chinese medicine preparation, this preparation method is relatively independent with Chinese medicine powder, will not pollute or destroy Chinese medicine ingredients and can improve the utilization rate of Effective Component of Chinese Medicine and the mouthfeel of Chinese medicine preparation。
For reaching above-mentioned purpose, the present invention provides techniques below scheme:
A kind of preparation method of attached dose of expanding foam solution of Chinese medicine preparation, including:
Step 1, in daily drunk water add comprise sugar or comprise albumen feedstuff and sugar culture medium as culture fluid；
Step 2, add microbe leaven when culture-liquid temp is room temperature, and stir and foam；
After foaming, form expanding foam solution when 4.5 ~ 6.5 at described culture fluid pH value, soak more than 12 hours for the Chinese medicine powder that will get ready；
Wherein, if described daily drunk water is common water purification, then described step 1 includes, before adding culture medium, described daily drunk water is carried out purified treatment；Or, after described step 1 before step 2, including: described culture fluid is carried out sterilization treatment。
The expanding foam solution produced in above-mentioned preparation method is pre-prepd attached dose of the preparation institute exclusively for Chinese medicine preparation, but preparation technology independently carries out, do not foam together with Chinese medicine, when hospital clinical uses, be specifically designed to the prepared slices of Chinese crude drugs/powder, add in expanding foam solution and soak, thus the effective ingredient fully dissolved in Chinese medicine, strengthen medicinal curative effect, improve medical material utilization rate, thus saving Chinese medicaments material, reduce dose and mouthfeel is good。
Preferably, in order to obtain better drug effect, the disease corresponding to the Chinese medicine powder got ready determines the acid demand of described disease, regulates the foamed time of described culture fluid according to described demand。
Preferably, add in described daily drunk water again after albumen feedstuff pulping。
Preferably, described albumen feedstuff, sugar, microbe leaven weight respectively described daily drunk water weight l.5%。
Preferably, foamed time is 3 ~ 7 days。
Preferably. soak time is 24 hours。
Preferably, albumen feedstuff is Semen Glycines, Semen Maydis, Herba bromi japonici any of which or several combinations。
Preferably, sugar is xylose, brown sugar, glucose any of which or several combinations。
Preferably, microbe leaven is probiotic bacteria, including yeast, bacillus subtilis, Bacillus licheniformis one of which or several combinations。
Preferably, in order to obtain sour-sweet mouthfeel, when culture fluid pH value is 5, form expanding foam solution。
The preparation method that the present invention also provides for a kind of Chinese medicine preparation, including: according to any of the above-described method, prepare expanding foam solution: the Chinese medicine powder got ready is immersed 12 hours drinkable medicine juice formed above in described expanding foam solution。
The independently prepared expanding foam solution of the method, do not foam together with Chinese medicine, avoid polluting, destroying or the effective elements of the medicine in impact, then Chinese medicine is soaked in the expanding foam solution prepared, fully dissolve the effective ingredient in Chinese medicine, strengthen medicinal curative effect, improve medical material utilization rate, thus saving Chinese medicaments material, reduce dose and mouthfeel is good。
Preferably, Chinese medicine powder is clean Chinese medicine powder。
Preferably, the part by weight of Chinese medicine and expanding foam solution is 1:5。
Accompanying drawing explanation
The preparation method flow chart of attached dose of expanding foam solution of a kind of Chinese medicine preparation that Fig. 1 provides for the embodiment of the present invention。
The preparation method flow chart of a kind of Chinese medicine preparation that Fig. 2 provides for the embodiment of the present invention。
Fig. 3 is the preparation method flow chart that the invention process holds a kind of Chinese traditional compound medicine of confession。
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is only a part of embodiment of the present invention, rather than whole embodiments。Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art obtain under not making creative work premise, broadly fall into the scope of protection of the invention。
Refer to Fig. 1, Fig. 2, the preparation method flow chart of attached dose of expanding foam solution of a kind of Chinese medicine preparation that Fig. 1 provides for the embodiment of the present invention；The preparation method flow chart of a kind of Chinese medicine preparation that Fig. 2 provides for the embodiment of the present invention。
As it is shown in figure 1, the preparation method of attached dose of expanding foam solution of a kind of Chinese medicine preparation of embodiment of the present invention offer, including:
SlOl, in daily drunk water add comprise sugar or comprise albumen feedstuff and sugar culture medium as culture fluid；After wherein adding albumen feedstuff, ferment faster, more fully；Wherein, albumen feedstuff can the form such as powdery, granule, it is preferable that by Pa'anga in daily drunk water again after albumen feedstuff pulping, ferment effect can be better。
S102, add microbe leaven when culture-liquid temp is room temperature, and stir and foam；
S103, through foaming after, forms expanding foam solution when 4.5-6.5 at described culture fluid pH value, for will get ready Chinese medicine powder immersion more than 12 hours。Wherein, this fact Example Chinese medicine powder is not limited to powdery, it is also possible to be any forms such as Chinese medicine tablet, Chinese medicine block, Chinese medicinal granule, and wherein, powdery ferments more fully, faster when soaking。
In above-mentioned preparation method produce expanding foam solution be according to Chinese medicine characteristic exclusively for Chinese medicine preparation preparation institute pre-prepd attached dose, but preparation technology independently carries out, do not foam together with Chinese medicine, when hospital clinical uses, be specifically designed to clean herbal mixture decoction pieces powder, add in expanding foam solution and soak, thus the effective ingredient fully dissolved in Chinese medicine, strengthen medicinal curative effect, improve medical material utilization rate, thus saving Chinese medicaments material, reduce dose；Patient can be about to directly take after medical material expanding foam solution soaks certainly, simple to operate, and soak time is short, facilitates patient with examining band medicine, takes in time, be beneficial to popularization。
Wherein, in step S10I, daily drunk water is mainly water purification, can be the water of the high cleanings such as pure water, distilled water, boiled water: but daily drunk water can also be the common water purification of well water, river, tap water etc., if described daily drunk water is common water purification, then step S10I includes, before adding culture medium, described daily drunk water is carried out purified treatment；Or, after described step SI01 before step Sl02, including: described culture fluid is carried out sterilization treatment: common water purification can be carried out purified treatment by pure water preparation technology or distillation technique by common water purification by purified treatment, is translated into the water of high purification；And sterilization treatment can be high temperature sterilize, ray sterilizing etc. such as, if described daily drunk water is the common water purification such as tap water, then add heat-sealing more than 80 degrees Celsius by adding the culture fluid after culture medium, it is desirable to outstanding reach 100
Degree Celsius, it is possible to continuing about 5 minutes, then treat that culture fluid cooling returns to room temperature, such expanding foam solution is clean, it is possible to deposits for a long time and puts for a long time。
Preferably, in order to obtain better therapeutic effect, disease corresponding to the Chinese medicine powder got ready determines the acid demand of described disease, the foamed time of described culture fluid is regulated according to described demand, because foamed time is more long, the pH value of expanding foam solution can be more little, namely expanding foam solution acidity can be more strong, and the acid demand of different syndromes is different, therefore foamed time is adjusted according to practical situation, such as: if the Chinese medicine powder correspondence treatment got ready is gastropathy, the then unsuitable peracid of expanding foam solution, otherwise can cause aggravation, the pH value of expanding foam solution should be faintly acid, foamed time is just corresponding to be shortened。
Preferably, when above-mentioned pH value is 4.5,5,5.5,6,6.5, mouthfeel is best, sweet and sour taste。
Preferably, the 1.5% of the weight that albumen feedstuff, sugar, fermentable cut open respectively described daily drunk water weight, this proportion is optimal proportion, now whole foaming process is effective, foamed time is short, foaming is abundant, the acidity of expanding foam solution is most suitable, can also be adjusted fluctuating in this ratio according to practical situation, it is desirable to scope is between l% ~ 2%。
Preferably, foamed time the best is 3 ~ 7 days, particularly 3 days more particularly suitable, expanding foam solution mouthfeel is sour-sweet suitable；The acidity of 5 days and 7 days can omit strong but mouthfeel is pretty good, and the time can determine according to concrete foaming situation, is advisable with sweet mouthfeel, improves the mouthfeel of Chinese medicine preparation。
Preferably, for the effective ingredient of abundant solution absorption Chinese medicine powder, obtaining best mouthfeel, soak time the best is 24 hours。
Preferably, more abundant in order to foam, albumen feedstuff is mainly any of which or several combinations such as Semen Glycines, Semen Maydis, Herba bromi japonici。
Preferably, in order to shorten foamed time, sugar can be any of which or several combinations such as xylose, brown sugar, glucose。
Preferably, microbe leaven is probiotic bacteria, one of which or several combinations such as including yeast, hay thatch spore bacillus, Bacillus licheniformis。By the expanding foam solution prepared with this microbial technique of probiotic bacteria, soak Chinese medicine, can fully dissolve the various effective ingredient in Chinese medicine, improve herbal medicine efficacy, and microbial metabolism produces ethanol, the organic acid etc. that enrich, correct the taste of medicine juice, it is prevented that raw corruption of going mouldy。
Make full use of microbial technique foaming technique and can produce multiple enzyme, such as amylase, glucose enzyme, protease, fibrinoclase etc. and multiple nutrients material, such as aminoacid, vitamin etc., bring out the best in each other with Effective Component of Chinese Medicine, improve curative effect of medication。
The expanding foam solution that the embodiment of the present invention is mentioned be Chinese medicine decoction one except conventional high-temperature decocting method supplement effectively solve after dosage form, expanding foam solution prepared by the preparation method provided by the above embodiment of the present invention and Chinese medicine mixing are soaked the prepared slices of Chinese crude drugs efficiently utilize, the problem such as mouthfeel bitterness, Normalization rule, sanitary standard。
As in figure 2 it is shown, the preparation method that the embodiment of the present invention also provides for a kind of Chinese medicine preparation, including:
S201, the Chinese medicine preparation provided by any of the above-described embodiment of the present invention the preparation method of attached dose of expanding foam solution prepare expanding foam solution:
S202, the Chinese medicine powder got ready is immersed 12 hours drinkable medicine juice formed above in described expanding foam solution。
The method, by according to the independently prepared expanding foam solution of herbal nature, then being soaked in the expanding foam solution prepared by Chinese medicine, is fully dissolved the effective ingredient in Chinese medicine, is strengthened medicinal curative effect, improve medical material utilization rate, thus saving Chinese medicaments material, reduces dose；And in Clinical practice, easy and simple to handle, the time is short, facilitates patient with examining band medicine, take in time, be beneficial to popularization。
Preferably, Chinese medicine powder is clean Chinese medicine powder, and clean Chinese medicine powder refers to free of contamination Chinese medicine powder, for instance can be dry Chinese medicine powder, it is also possible to be the Chinese medicine powder steamed by high temperature: be so possible to prevent moldy metamorphism, be beneficial to long-term preservation。
Expanding foam solution is very few, dissolves insufficient；Expanding foam solution is too much, relatively just increases each serving consumption: in order under guaranteeing effective premise so that patient per's dose is less, preferably, the optimal proportion of Chinese medicine and expanding foam solution weight is 1:5, but can be adjusted according to practical situation, fluctuates in this ratio。
The embodiment of the present invention provides the preparation method flow chart of a kind of Chinese traditional compound medicine, and daily drunk water is for tap water。
Under room temperature, pour tap water into, add and form culture fluid after comprising bean milk (Semen Glycines making beating) and the culture medium of brown sugar, it is heated to 100 degree, after continuing about 5 minutes, carry out naturally cooling to room temperature: when then culture fluid is room temperature, interpolation compound probiotic foams, uniform stirring on the one is once, through foaming in more than three days, reach sweet mouthfeel to be advisable, form expanding foam solution, it is desirable to cross the solid residues such as elimination bean dregs: then soaked 24 hours in sending out stoke liquid by clean Chinese medicine powder, drinkable Chinese medicine preparation can be formed；Preferably after solid residues such as elimination medicinal residues。
The embodiment of the present invention adopts the first standby this special technological process of production of independently prepared expanding foam solution, only need Chinese medicine powder and expanding foam solution are mixed immersion and capable of direct drinking, without carrying out the complicated approach such as high temperature decoction, and when hospital clinical uses, patient can with examining band medicine, easy to use, it is adaptable to all kinds of acute and chronic diseases。
In expanding foam solution preparation process, by using microbial technique fully to dissolve Effective Component of Chinese Medicine, solve high temperature and decoct the destruction to part Effective Component of Chinese Medicine and the problem being insoluble in water, Effective Component of Chinese Medicine can be made full use of, thus enhance medicinal curative effect, improve medical material utilization rate, saved Chinese crude drug, decrease dose；Microorganism creates abundant ethanol, organic acid etc. in metabolic process, it is possible to correct the taste of medicine juice. prevent raw corruption of going mouldy, so medicine juice sweet and sour mouthfeel is good, change the bitter taste of Chinese medicine, whole process is not added with any preservative, need not special store method, deposit for a long time to put for a long time and never degenerate。
It addition, hospital clinical is easy to use, it is easy to accept, it is easy to promote and also have the features such as drug effect is high, consumption is few, mouthfeel good, deposit for a long time。
Obviously, the embodiment of the present invention can be carried out various change and modification without deviating from the spirit and scope of the present invention by those skilled in the art。So, if these amendments of the present invention and modification belong within the scope of the claims in the present invention and equivalent technologies thereof, then the present invention is also intended to comprise these change and modification。
Claims (14)
1. a preparation method for attached dose of expanding foam solution of Chinese medicine preparation, its special type is in that, including:
Step 1: add the culture medium comprising sugar or comprise albumen feedstuff and sugar in daily drunk water as culture fluid；
Step 2: add microbe leaven when culture-liquid temp is room temperature, and stir and foam；
Step 3: after foaming, forms expanding foam solution when 4.5 ~ 6.5 at described culture fluid pH value, soaks more than 12 hours for the Chinese medicine powder that will get ready；
Wherein, if described daily drunk water is common water purification, then described step 1 includes, before adding culture medium, described daily drunk water is carried out purified treatment；Or, after described step 1 before step 2, including: described culture fluid is carried out sterilization treatment。
2. Chinese medicinal preparation method according to claim 1, it is characterised in that described culture fluid is carried out sterilization treatment, including: described culture fluid is heated to more than 80 degrees Celsius, is cooled to room temperature；
Described purified treatment includes: by pure water preparation technology or distillation technique, described daily drunk water is carried out purified treatment。
3. Chinese medicinal preparation method according to claim 1, it is characterised in that further comprise the steps of: the acid demand determining described disease according to the disease corresponding to Chinese medicine powder got ready, the foamed time of culture fluid according to described demand regulating step 2。
4. Chinese medicinal preparation method according to claim 1, it is characterised in that add in described daily drunk water again after described albumen feedstuff pulping。
5. Chinese medicinal preparation method according to claim 4, it is characterised in that described albumen feedstuff, sugar, microbe leaven weight respectively described daily drunk water weight 1.5%。
6. Chinese medicinal preparation method according to claim 1, it is characterised in that described foamed time is 3 ~ 7 days。
7. Chinese medicinal preparation method according to claim 1, it is characterised in that described soak time is 24 hours。
8. Chinese medicinal preparation method according to claim 4, it is characterised in that described albumen feedstuff is Semen Glycines, Semen Maydis, Herba bromi japonici any of which or several combinations。
9. according to the arbitrary described Chinese medicinal preparation method of claim 1 ~ 8, it is characterised in that described sugar is xylose, brown sugar, glucose any of which or several combinations。
10. according to the arbitrary described Chinese medicinal preparation method of claim 1 ~ 8, it is characterised in that described microbe leaven is probiotic bacteria, including yeast, bacillus subtilis, Bacillus licheniformis one of which or several combinations。
11. according to the arbitrary described Chinese medicinal preparation method of claim 1 ~ 8, it is characterised in that described culture fluid pH value is 5 formation expanding foam solutions。
12. the preparation method of a Chinese medicine preparation, it is characterised in that including:
According to claim 1 ~ 11, either method prepares expanding foam solution；
The Chinese medicine got ready is immersed 12 hours drinkable medicine juice formed above in described expanding foam solution。
13. Chinese medicinal preparation method according to claim 12, it is characterised in that described Chinese medicine powder is clean Chinese medicine powder。
14. Chinese medicinal preparation method according to claim 12, it is characterised in that the part by weight of described Chinese medicine and expanding foam solution is 1:5。
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| CN107095946A (en) * | 2017-04-10 | 2017-08-29 | 运城市盐湖区中医院 | A kind of preparation method of ageratum Chinese patent drug foaming aqua |
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