CN105664044A - Traditional Chinese medicine combined extract with anti-depression effect as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine combined extract with anti-depression effect as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine combined extract with an anti-depression effect as well as a preparation method and application thereof and belongs to the technical field of traditional Chinese medicinal preparations. The traditional Chinese medicine combined extract with the anti-depression effect is prepared from salviae miltiorrhizae, ligusticum wallichii, kudzuvine root and earthworm in certain parts by weight. The traditional Chinese medicine combined extract is scientific in compatibility and reasonable in preparation; experiments show that the traditional Chinese medicine combined extract or traditional Chinese medicine tablets thereof can obviously reduce the dead time of mouse tail suspension and forced swimming of a behavioural despair model, and open-field test results show that the autonomic activity of a mouse is not influenced while the dead time is reduced; and meanwhile, the traditional Chinese medicine combined extract also can obviously resist mouse body temperature decrease caused by reserpine and obviously improve the mouse head shaking frequency induced by 5-hydroxytryptophane, so that the traditional Chinese medicine combined extract has the anti-depression effect, plays a role by changing the monoaminergic level in the brain, and has an application prospect of being developed into an anti-depression drug.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, it is specifically related to a kind of Chinese traditional medicine composition extract with antidepressant effect and its preparation method and application.
Background technology
Dysthymia disorders is a kind of take depressive mood as the main disease showed, and is usually ignored because health can not cause directly harm. At present, in developed country, depression is 15 kinds of main one of reasons that disable. Data according to the U.S., the U.S. about has 1,100 ten thousand people to suffer from clinical depression every year, and the homicide rate of clinical depression patient is 10～15%, by the impact of this disease, annual approximately loss 20,000,000,000 dollars. Domestic survey data shows, and the homicide rate of dysthymia disorders is about higher than general crowd 20 times. Visible dysthymia disorders is very big to the threat of human health. Predicting the year two thousand twenty, dysthymia disorders will become the second largest disability-causing factor of the mankind being only second to cancer. Psychosomatics, medicopsychology, psychiatry etc. recently research data show, the existing morbidity of typical psychosomatic disease dysthymia disorders has exceeded cardiovascular and cerebrovascular diseases and tumour, leap to developed country first.
The Western medicine of all kinds of dysthymia disorders for the treatment of mainly contains tricyclic antidepressants (abbreviation TCA at present, it is divided into miaow piperazine class, general woods class, dibenzo table class etc.), oxidase inhibitor (be called for short MAOI, such as isopropyl hydrazine etc.) and 5-HT reuptake inhibitor (abbreviation SSRI, such as fluoxetine etc.), but generally there is the drawbacks such as resistance, toxic side effect be big in Western medicine, therefore finding antidepressant drug safe, efficient, that side effect is little particularly important, especially natural antidepressant drug becomes the research focus in this field.
Summary of the invention
It is an object of the invention to as solving the problem, it is provided that a kind of Chinese traditional medicine composition extract with antidepressant effect.
The object of the present invention is realized by following technical proposals:
A Chinese traditional medicine composition extract with antidepressant effect, is made up of the raw material of following weight part ratio: red sage root 10-20 part, Ligusticum wallichii 8-15 part, root of kudzu vine 8-15 part, earthworm 8-15 part, radix paeoniae rubrathe 8-12 part, safflower 6-10 part, root tuber of aromatic turmeric 1 part, Radix Polygoni Multiflori Preparata 8-15 part, rhizoma alismatis 8-12 part, matrimony vine 8-15 part, Spina Date Seed 6-10 part, polygala root 6-12 part, Rhizome of Irkutsk Anemone 8-15 part, root of bidentate achyranthes 8-12 part, Radix Glycyrrhizae 5-10 part.
Alternately, the Chinese traditional medicine composition extract described in antidepressant effect is made up of the raw material of following weight part ratio: the red sage root 14 parts, Ligusticum wallichii 10 parts, the root of kudzu vine 10 parts, earthworm 10 parts, the radix paeoniae rubrathe 10 parts, 7 parts, safflower, root tuber of aromatic turmeric 1 part, Radix Polygoni Multiflori Preparata 10 parts, rhizoma alismatis 10 parts, matrimony vine 10 parts, Spina Date Seed 7 parts, polygala root 10 parts, Rhizome of Irkutsk Anemone 10 parts, the root of bidentate achyranthes 10 parts, 7 parts, Radix Glycyrrhizae.
Alternately, the Chinese traditional medicine composition extract described in antidepressant effect is made up of the raw material of following weight part ratio: red sage root 7-17 part, Ligusticum wallichii 8-16 part, root of kudzu vine 6-13 part, earthworm 7-12 part, radix paeoniae rubrathe 8-12 part, safflower 5-9 part, root tuber of aromatic turmeric 1-2 part, Radix Polygoni Multiflori Preparata 8-15 part, rhizoma alismatis 7-9 part, matrimony vine 9-16 part, Spina Date Seed 5-8 part, polygala root 6-12 part, Rhizome of Irkutsk Anemone 8-15 part, root of bidentate achyranthes 6-10 part, Radix Glycyrrhizae 4-8 part, radix bupleuri 3-7 part, Radix Et Caulis Acanthopanacis Senticosi 6-8 part, turmeric 7-10 part, wind-weed 4-10 part.
Alternately, the Chinese traditional medicine composition extract described in antidepressant effect is made up of the raw material of following weight part ratio: the red sage root 15 parts, Ligusticum wallichii 10 parts, the root of kudzu vine 8 parts, earthworm 8 parts, the radix paeoniae rubrathe 10 parts, 6 parts, safflower, root tuber of aromatic turmeric 1 part, Radix Polygoni Multiflori Preparata 10 parts, rhizoma alismatis 8 parts, matrimony vine 13 parts, Spina Date Seed 7 parts, polygala root 8 parts, Rhizome of Irkutsk Anemone 10 parts, the root of bidentate achyranthes 8 parts, 6 parts, Radix Glycyrrhizae, radix bupleuri 5 parts, Radix Et Caulis Acanthopanacis Senticosi 7 parts, 9 parts, turmeric, the wind-weed 6 parts.
Present invention also offers a kind of described in there is the preparation method of Chinese traditional medicine composition extract of antidepressant effect, it is characterised in that, comprise the following steps:
(1) get each raw material respectively, clean, dry;
(2) each raw material after process in step (1) is taken by weight;
(3) measured for title Chinese medicine being added 8-12 times of water heating and refluxing extraction 2-3 time, each 1-2 hour, filter, merging filtrate, obtains having the Chinese traditional medicine composition extract of antidepressant effect.
Alternately, in above-mentioned preparation method, also comprise the following steps in described step (3): gained filtrate in step (3) is concentrated the clear cream to relative density 1.10～1.15 (60 DEG C), and spraying dry obtains extract medicinal extract.
Present invention also offers a kind of Chinese medicinal tablet with antidepressant effect, it is characterised in that, any one Chinese traditional medicine composition extract with antidepressant effect above is the tablet that main active ingredient obtains.
Alternately, the described Chinese medicinal tablet with antidepressant effect comprises the moiety of following weight percent: 1%-3% carboxymethylstach sodium, 9%-12% Microcrystalline Cellulose, 4%-6% starch, 0.2%-0.5% Magnesium Stearate, surplus is any one Chinese traditional medicine composition extract with antidepressant effect above.
Present invention also offers a kind of method preparing above-mentioned Chinese medicinal tablet: described Chinese traditional medicine composition extract is concentrated the clear cream to relative density 1.10～1.15 (60 DEG C), spraying dry makes extract medicinal extract, then each component materials dry powder is fully mixed, dry granulation, cross 80 order sieves, control the heavy 0.42g compressing tablet of every sheet, wrap thin clothing sheet and get final product.
Present invention also offers a kind of described Chinese traditional medicine composition extract or Chinese medicinal tablet in the application prepared in the mental disorder medicines such as Cure of depression.
All features disclosed in this specification sheets, or the step in disclosed all methods or process, except mutually exclusive feature and/or step, all can combine by any way.
The useful effect of the present invention:
Compatibility science of the present invention, preparation is rationally, described Chinese traditional medicine composition extract or its Chinese medicinal tablet is found through experiment, can significantly reduce the dead time of the outstanding tail of behavioral despair model mice and forced swimming, spacious field experimental result proves simultaneously, does not affect the autonomic activities ability of mouse while reducing the dead time; A number of times can also be got rid of with the mouse of the mouse temperature decline caused and significantly increase by five Quietim induction by remarkable anti-serpentine short of money simultaneously, it is all pointed out to have antidepressant effect, and play a role by changing single amine energy level in brain, there is the application prospect that exploitation becomes a kind of antidepressant drug.
Embodiment
By the following examples the present invention is specifically described; what be necessary to herein means out is that the present embodiment is only used to further illustrate the present invention; but can not being interpreted as limiting the scope of the invention, the present invention can be made improvement and the adjustment of some non-intrinsically safes by the person skilled in the art in this field according to the content of above-mentioned the present invention.
Embodiment 1:
Get red sage root 140g, Ligusticum wallichii 100g, root of kudzu vine 100g, earthworm 100g, radix paeoniae rubrathe 100g, safflower 70g, root tuber of aromatic turmeric 10g, Radix Polygoni Multiflori Preparata 100g, rhizoma alismatis 100g, matrimony vine 100g, Spina Date Seed 70g, polygala root 100g, Rhizome of Irkutsk Anemone 100g, root of bidentate achyranthes 100g, Radix Glycyrrhizae 70g. Times water heating and refluxing extraction that adds 10 by measured for title Chinese medicine 3 times, each 1 hour, filters, and merging filtrate, obtains having the Chinese traditional medicine composition extract of antidepressant effect; Gained filtrate concentrates the clear cream to relative density 1.10 (60 DEG C), and spraying dry obtains extract medicinal extract; Forming according to following weight percent: 2% carboxymethylstach sodium, 10% Microcrystalline Cellulose, 5% starch, 0.5% Magnesium Stearate, surplus is extract medicinal extract. Above-mentioned substance dry powder is fully mixed, dry granulation, cross 80 order sieves, control the heavy 0.42g compressing tablet of every sheet, wrap thin clothing sheet and get final product.
Embodiment 2:
To mouse antidepressant Expermental research on main pharmacodynamics.
1. on the impact of behavioral despair model mice Depressive behavior
Fluoxetine HCl capsules, Chinese and Western, Shanghai pharmacy company limited; Experiment tablet: the tablet of preparation in embodiment 1, the every sheet of 0.42g (is equivalent to crude drug amount and is about 0.6g).
Cleaning grade kunming mice, male and female half and half, body weight 18-22g, animal sub-cage rearing, keeps 12h diel rhythm, room temperature 24 ± 1 DEG C, freely drink water and ingest, mouse is divided at random five groups, often organize 10, male and female half and half, are respectively: blank group (physiological saline, 0.1ml/kg, i.g.), experiment slice agent dose group, positive controls (fluoxetine, 10mg/kg, i.g.), every treated animal successive administration 7 days.
According to raw medicine calculation, every day, the consumption of 70kg people was 5.4g, every sheet tablet 0.42g is about containing crude drug amount 0.6g, namely daily requirement divide 3 times each 3 take, therefore the consumption of dosage mouse of often merely hitting every day is: 5.4*10/70=0.777g/kg crude drug amount, according to the raw medicine calculation of 0.8g/kg, namely dosage mouse in, every day, every tablet dose only was 0.75g/kg, separately, high low dose group dosage is set and is respectively 2.0g/kg and 0.25g/kg tablet, by fluoxetine with experiment tablet according to dosage and 0.1ml/10g administration volume, every mouse administration scope is between 0.2ml～0.8ml, with physiological saline solution, it is configured to the solution of appropriate concentration.
(1) spacious field experiment
It is put in the case of spacious field after mouse last administration 1h. Observe every animal at 5min, horizontal score (passing through grid number of times) and vertical score (mouse forelimb upwards praises number of times) in 3min after recording each group of mouse.
(2) forced swim test
After last administration 1h, animal is put in water temperature 23-25 DEG C of bucket respectively, make animal hind leg can not lean on bucket bottom support health. This experiment is made up of two portions: first carries out 15min and swims in advance, observes the swimming behavior in 6min after 24h, the dead time in 5min after record.
(3) the not dynamic experiment of outstanding tail
After last administration 1h, one end of fine rule it is affixed on apart from about 1cm place, position, mouse tail tip medical proof fabric, the other end is connected with the tonotransducer being connected with, mouse head is about 5cm from table top, once hang 2 mouse, centre blank sheet of paper separates, and the suspension time is 6min, the accumulative dead time of mouse in the rear 5min of statistics.
(4) result
On the impact of mouse autonomic activities ability
Result is as shown in table 1, and successive administration is after 7 days, the experiment high, normal, basic dosage group of tablet and extract with fluoxetine group, in spacious field is tested, and spontaneous activity in mice compares with blank group that there are no significant the change of divergence.Show to test the autonomic activities ability that tablet can't affect mouse.
Table 1 on the impact of mouse spontaneous activity (n=10,)
Mouse forced swimming test result
Result is as shown in table 2, and successive administration is after 7 days, and experiment tablet senior middle school dosage group compared with blank group, all can significantly reduce the dead time of mouse in forced swim test with fluoxetine positive controls.
Table 2 on the impact of mouse forced swimming test dead time (n=10,)
Note: compare with blank group, * p < 0.05, * * p < 0.01.
The not dynamic experimental result of mouse tail suspension
Result is as shown in table 3, and successive administration is after 7 days, and experiment tablet high dose group compared with blank group, all can significantly reduce the dead time of mouse in forced swim test with fluoxetine positive controls.
Table 3 on the impact of mouse tail suspension dead time (n=10,)
Note: compare with blank group, * p < 0.05, * * p < 0.01.
(5) conclusion
This experiment research proves, experiment tablet can significantly reduce the dead time in mouse forced swimming test and tail-suspention test at successive administration after 7 days, shows certain antidepressant ability; Meanwhile, the experiment of spacious field proves that experiment tablet can not affect mouse autonomic activities ability.
2, on the impact of drug-induced antidepressant model mice behavior
5-hydroxyryptophan (5-Hydroxy-DL-tryptophan, 5-HTP), Sigma company; Serpentine, Sgima company; 5-hydroxyryptophan (5-Hydroxy-DL-tryptophan, 5-HTP), Sigma company; Serpentine, Sgima company; Experiment tablet: the tablet of preparation in embodiment 1, the every sheet of 0.42g (is equivalent to crude drug amount and is about 0.6g).
Cleaning grade kunming mice, male and female half and half, body weight 18-22g, animal sub-cage rearing, keeps 12h diel rhythm, room temperature 24 ± 1 DEG C, freely drink water and ingest, mouse is divided at random five groups, often organize 10, male and female half and half, are respectively: blank group (physiological saline, 0.1ml/kg, i.g.), experiment slice agent dose group, positive controls (fluoxetine, 10mg/kg, i.g.), every treated animal successive administration 7 days.
According to raw medicine calculation, every day, the consumption of 70kg people was 5.4g, every sheet tablet 0.42g is about containing crude drug amount 0.6g, namely daily requirement divide 3 times each 3 take, therefore the consumption of dosage mouse of often merely hitting every day is: 5.4*10/70=0.777g/kg crude drug amount, according to the raw medicine calculation of 0.8g/kg, namely dosage mouse in, every day, every tablet dose only was 0.75g/kg, separately, high low dose group dosage is set and is respectively 2.0g/kg and 0.25g/kg tablet, by fluoxetine with experiment tablet according to dosage and 0.1ml/10g administration volume, every mouse administration scope is between 0.2ml～0.8ml, with physiological saline solution, it is configured to the solution of appropriate concentration.
(1) head experiment is got rid of in 5-HTP induction
Animals administer and grouping are with, described in embodiment 2, each treated animal successive administration is after 7 days, and last administration 1h pneumoretroperitoneum injects 100mg*kg-15-HTP, starts after administration 5min to observe 15min continuously, and record is often organized mouse and got rid of a number of times separately.
(2) reserpine induction experiment
Each treated animal successive administration is after 7 days, and after last administration 1h, except the capacity distilled water such as control group gavage, other respectively organizes abdominal injection 4mg*kg-1Serpentine, carries out the observation of body temperature decline respectively, and except control group, other respectively organizes abdominal injection 4mg*kg-1Serpentine, simultaneously oral pharmaceutical or physiological saline, the physiological saline of the capacity such as control group abdominal injection.
(3) experimental result
On the impact of 5-HTP Induction experiments
The results are shown in Table described in 4, compared with blank group, positive control drug fluoxetine dosage group and experiment tablet senior middle school dosage group, what all can significantly increase mouse gets rid of a number of times.
Table 4 on the impact of 5-HTP Induction experiments (n=10,)
Note: compare with blank group, * p < 0.05, * * p < 0.01.
On the impact of reserpine induction experiment
The results are shown in Table described in 5, compared with blank group, positive control drug fluoxetine dosage group and the experiment high, normal, basic dosage group of tablet, all can the effect of remarkable anti-reserpine induction mouse temperature short of money decline.
Impact that reserpine induction is tested by table 5 (n=10,)
Note: comparing with blank group, ##p < 0.01, compares with model group, * p < 0.05, * * p < 0.01.
4 conclusions
This experiment research proves, the head that gets rid of that experiment tablet senior middle school dosage group can significantly increase mouse 5-HTP induction is tested, and points out it to have antidepressant effect; Meanwhile, the experiment low middle high dose group successive administration of tablet is after 7 days, and the mouse temperature decline that all the remarkable anti-reserpine induction short of money of energy causes, prompting experiment tablet has antidepressant effect, and its empty space Effect and impact maincenter monoaminergic nerve system is relevant.
In above-mentioned each experiment, described experiment tablet is changed into embodiment 1 is prepared Chinese traditional medicine composition extract (extract doses calculates by the extract actual dose contained corresponding in described experiment slice agent dose), the result basically identical with above-mentioned experimental result can be obtained, it was demonstrated that described Chinese traditional medicine composition extract has antidepressant effect.
Embodiment 3:
Get red sage root 100g, Ligusticum wallichii 150g, root of kudzu vine 80g, earthworm 80g, radix paeoniae rubrathe 120g, safflower 100g, root tuber of aromatic turmeric 10g, Radix Polygoni Multiflori Preparata 150g, rhizoma alismatis 80g, matrimony vine 80g, Spina Date Seed 100g, polygala root 60g, Rhizome of Irkutsk Anemone 150g, root of bidentate achyranthes 80g, Radix Glycyrrhizae 100g. Times water heating and refluxing extraction that adds 12 by measured for title Chinese medicine 3 times, each 1.5 hours, filters, and merging filtrate, obtains having the Chinese traditional medicine composition extract of antidepressant effect; Gained filtrate concentrates the clear cream to relative density 1.15 (60 DEG C), and spraying dry obtains extract medicinal extract; Forming according to following weight percent: 3% carboxymethylstach sodium, 9% Microcrystalline Cellulose, 6% starch, 0.3% Magnesium Stearate, surplus is extract medicinal extract. Above-mentioned substance dry powder is fully mixed, dry granulation, cross 80 order sieves, control the heavy 0.42g compressing tablet of every sheet, wrap thin clothing sheet and get final product.
Embodiment 4:
Get red sage root 200g, Ligusticum wallichii 80g, root of kudzu vine 150g, earthworm 150g, radix paeoniae rubrathe 80g, safflower 60g, root tuber of aromatic turmeric 10g, Radix Polygoni Multiflori Preparata 80g, rhizoma alismatis 120g, matrimony vine 150g, Spina Date Seed 60g, polygala root 120g, Rhizome of Irkutsk Anemone 80g, root of bidentate achyranthes 120g, Radix Glycyrrhizae 50g. Times water heating and refluxing extraction that adds 8 by measured for title Chinese medicine 2 times, each 2 hours, filters, and merging filtrate, obtains having the Chinese traditional medicine composition extract of antidepressant effect; Gained filtrate concentrates the clear cream to relative density 1.12 (60 DEG C), and spraying dry obtains extract medicinal extract; Forming according to following weight percent: 1% carboxymethylstach sodium, 12% Microcrystalline Cellulose, 4% starch, 0.2% Magnesium Stearate, surplus is extract medicinal extract. Above-mentioned substance dry powder is fully mixed, dry granulation, cross 80 order sieves, control the heavy 0.42g compressing tablet of every sheet, wrap thin clothing sheet and get final product.
Embodiment 5:
Get red sage root 150g, Ligusticum wallichii 100g, root of kudzu vine 80g, earthworm 80g, radix paeoniae rubrathe 100g, safflower 60g, root tuber of aromatic turmeric 10g, Radix Polygoni Multiflori Preparata 100g, rhizoma alismatis 80g, matrimony vine 130g, Spina Date Seed 70g, polygala root 80g, Rhizome of Irkutsk Anemone 100g, root of bidentate achyranthes 80g, Radix Glycyrrhizae 60g, radix bupleuri 50g, Radix Et Caulis Acanthopanacis Senticosi 70g, turmeric 90g, wind-weed 60g.Times water heating and refluxing extraction that adds 10 by measured for title Chinese medicine 3 times, each 1 hour, filters, merging filtrate; Gained filtrate concentrates the clear cream to relative density 1.10 (60 DEG C), and spraying dry obtains extract medicinal extract; Forming according to following weight percent: 2% carboxymethylstach sodium, 10% Microcrystalline Cellulose, 5% starch, 0.5% Magnesium Stearate, surplus is extract medicinal extract. Above-mentioned substance dry powder is fully mixed, dry granulation, cross 80 order sieves, control the heavy 0.42g compressing tablet of every sheet, wrap thin clothing sheet and get final product.
Embodiment 6:
Each raw material, all through cleaning, after dry, gets red sage root 7-17 part, Ligusticum wallichii 8-16 part by weight, root of kudzu vine 6-13 part, earthworm 7-12 part, radix paeoniae rubrathe 8-12 part, safflower 5-9 part, root tuber of aromatic turmeric 1-2 part, Radix Polygoni Multiflori Preparata 8-15 part, rhizoma alismatis 7-9 part, matrimony vine 9-16 part, Spina Date Seed 5-8 part, polygala root 6-12 part, Rhizome of Irkutsk Anemone 8-15 part, root of bidentate achyranthes 6-10 part, Radix Glycyrrhizae 4-8 part, radix bupleuri 3-7 part, Radix Et Caulis Acanthopanacis Senticosi 6-8 part, turmeric 7-10 part, wind-weed 4-10 part. Measured for title Chinese medicine being added 8-12 times of water heating and refluxing extraction 2-3 time, each 1-2 hour, filter, merging filtrate, obtains having the Chinese traditional medicine composition extract of antidepressant effect; Gained filtrate concentrates the clear cream to relative density 1-10～1.15 (60 DEG C), and spraying dry obtains extract medicinal extract; Forming according to following weight percent: 1%-3% carboxymethylstach sodium, 9%-12% Microcrystalline Cellulose, 4%-6% starch, 0-2%-0.5% Magnesium Stearate, surplus is extract medicinal extract. Above-mentioned substance dry powder is fully mixed, dry granulation, cross 80 order sieves, control the heavy 0.42g compressing tablet of every sheet, wrap thin clothing sheet and get final product.
Embodiment 7:
With reference to the experimental technique described in embodiment 2, each group of Chinese traditional medicine composition extract and tablet thereof to preparation in embodiment 3-6 carry out Expermental research on main pharmacodynamics. result shows: in embodiment 3 and 4, the Chinese traditional medicine composition extract of gained and tablet thereof are suitable to the effect of the Chinese traditional medicine composition extract prepared in the antidepressant effect of mouse and embodiment 1 and tablet thereof, all demonstrate obvious antidepressant effect, and the Chinese traditional medicine composition extract of preparation in embodiment 5 and 6 and tablet thereof are to the antidepressant effect of mouse more excellent than the Chinese traditional medicine composition extract of preparation in embodiment 1 and tablet thereof (difference of statistical analysis display experimental data has statistical significance), wherein the Chinese traditional medicine composition extract of preparation in embodiment 5 and the antidepressant effect of tablet thereof are best.
The foregoing is only the preferred embodiments of the present invention, it is only explanation property for the purpose of the present invention, but not restrictive; Those of ordinary skill in the art understand, and it can be carried out many changes in the spirit and scope that the present invention limits, amendment, and even equivalence is changed, but all will fall into protection scope of the present invention.
Claims (10)
1. one kind has the Chinese traditional medicine composition extract of antidepressant effect, it is characterised in that, it is made up of the raw material of following weight part ratio: red sage root 10-20 part, Ligusticum wallichii 8-15 part, root of kudzu vine 8-15 part, earthworm 8-15 part, radix paeoniae rubrathe 8-12 part, safflower 6-10 part, root tuber of aromatic turmeric 1 part, Radix Polygoni Multiflori Preparata 8-15 part, rhizoma alismatis 8-12 part, matrimony vine 8-15 part, Spina Date Seed 6-10 part, polygala root 6-12 part, Rhizome of Irkutsk Anemone 8-15 part, root of bidentate achyranthes 8-12 part, Radix Glycyrrhizae 5-10 part.
2. the Chinese traditional medicine composition extract with antidepressant effect according to claim 1, it is characterised in that, it is made up of the raw material of following weight part ratio: the red sage root 14 parts, Ligusticum wallichii 10 parts, the root of kudzu vine 10 parts, earthworm 10 parts, the radix paeoniae rubrathe 10 parts, 7 parts, safflower, root tuber of aromatic turmeric 1 part, Radix Polygoni Multiflori Preparata 10 parts, rhizoma alismatis 10 parts, matrimony vine 10 parts, Spina Date Seed 7 parts, polygala root 10 parts, Rhizome of Irkutsk Anemone 10 parts, the root of bidentate achyranthes 10 parts, 7 parts, Radix Glycyrrhizae.
3. the Chinese traditional medicine composition extract with antidepressant effect according to claim 1, it is characterised in that, it is made up of the raw material of following weight part ratio: red sage root 7-17 part, Ligusticum wallichii 8-16 part, root of kudzu vine 6-13 part, earthworm 7-12 part, radix paeoniae rubrathe 8-12 part, safflower 5-9 part, root tuber of aromatic turmeric 1-2 part, Radix Polygoni Multiflori Preparata 8-15 part, rhizoma alismatis 7-9 part, matrimony vine 9-16 part, Spina Date Seed 5-8 part, polygala root 6-12 part, Rhizome of Irkutsk Anemone 8-15 part, root of bidentate achyranthes 6-10 part, Radix Glycyrrhizae 4-8 part, radix bupleuri 3-7 part, Radix Et Caulis Acanthopanacis Senticosi 6-8 part, turmeric 7-10 part, wind-weed 4-10 part.
4. the Chinese traditional medicine composition extract with antidepressant effect according to claim 1, it is characterised in that, it is made up of the raw material of following weight part ratio: the red sage root 15 parts, Ligusticum wallichii 10 parts, the root of kudzu vine 8 parts, earthworm 8 parts, the radix paeoniae rubrathe 10 parts, 6 parts, safflower, root tuber of aromatic turmeric 1 part, Radix Polygoni Multiflori Preparata 10 parts, rhizoma alismatis 8 parts, matrimony vine 13 parts, Spina Date Seed 7 parts, polygala root 8 parts, Rhizome of Irkutsk Anemone 10 parts, the root of bidentate achyranthes 8 parts, 6 parts, Radix Glycyrrhizae, radix bupleuri 5 parts, Radix Et Caulis Acanthopanacis Senticosi 7 parts, 9 parts, turmeric, the wind-weed 6 parts.
5. one kind has the Chinese medicinal tablet of antidepressant effect, it is characterised in that, the tablet that the Chinese traditional medicine composition extract with antidepressant effect any one of in claim 1-4 obtains as main active ingredient.
6. the Chinese medicinal tablet with antidepressant effect according to claim 5, it is characterized in that, comprise the moiety of following weight percent: 1%-3% carboxymethylstach sodium, 9%-12% Microcrystalline Cellulose, 4%-6% starch, 0.2%-0.5% Magnesium Stearate, surplus is the Chinese traditional medicine composition extract with antidepressant effect any one of in claim 1-4.
7. according to the preparation method of the Chinese traditional medicine composition extract with antidepressant effect any one of in claim 1-4, it is characterised in that, comprise the following steps:
(1) get each raw material respectively, clean, dry;
(2) each raw material after process in step (1) is taken by weight;
(3) measured for title Chinese medicine being added 8-12 times of water heating and refluxing extraction 2-3 time, each 1-2 hour, filter, merging filtrate, obtains having the Chinese traditional medicine composition extract of antidepressant effect.
8. preparation method according to claim 7, it is characterized in that, also comprise the following steps in described step (3): gained filtrate in step (3) is concentrated the clear cream to relative density 1.10～1.15 (60 DEG C), and spraying dry obtains extract medicinal extract.
9. the preparation method of the Chinese medicinal tablet with antidepressant effect according to claim 5, it is characterized in that, described Chinese traditional medicine composition extract is concentrated the clear cream to relative density 1.10～1.15 (60 DEG C), spraying dry makes extract medicinal extract, then each component materials dry powder is fully mixed, dry granulation, cross 80 order sieves, control the heavy 0.42g compressing tablet of every sheet, wrap thin clothing sheet and get final product.
10. Chinese traditional medicine composition extract as described in claim 1-4 or Chinese medicinal tablet according to claim 5 are in the application prepared in the mental disorder medicines such as Cure of depression.
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