CN1500509A - Traditional Chinese medicine composition for blahs and anxiety - Google Patents
Traditional Chinese medicine composition for blahs and anxiety Download PDFInfo
- Publication number
- CN1500509A CN1500509A CNA021486204A CN02148620A CN1500509A CN 1500509 A CN1500509 A CN 1500509A CN A021486204 A CNA021486204 A CN A021486204A CN 02148620 A CN02148620 A CN 02148620A CN 1500509 A CN1500509 A CN 1500509A
- Authority
- CN
- China
- Prior art keywords
- heart
- chinese medicine
- medicine composition
- depression
- anxiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
Abstract
The present invention is one kind of Chinese medicine composition, named Xinyue, with obvious treating effect on depression and anxiety neurosis. The Chinese medicine composition is the mixture of ginseng, tuckahoe, grassleaved sweetflag rhizome and polygala root in certain proportion or the mixture of their active components extracted, and may be prepared into various preparation forms. It is suitable for depression and anxiety neurosis caused by different reasons, and has the action mechanism of raising the content of NE, 5-HT and metabolism product 5-HIAA in body, activating the 5-HT neuron in brain and lowering the content of corticosteroid in depression blood plasma.
Description
Technical field
The invention belongs to the field of Chinese medicines, mainly provide a kind of and have a tangible antidepressant effect Chinese medicine composition by what Radix Ginseng, Poria, Rhizoma Acori Graminei, Radix Polygalae were formed, and by Radix Ginseng, Poria, Rhizoma Acori Graminei, Radix Polygalae through extract, concentrate, refining each active constituents of medicine that obtains, promptly ginsenoside, pachyman, Rhizoma Acori Graminei volatile ingredient/involatile constituent, polygalic acid are or/and the compositions that polysaccharide is formed.Be specifically related to depression, the application of anxiety symptom and the application for preparing antidepressant, anxiety product thereof that they cause at the treatment a variety of causes.In its antidepressant effect and the depressed animal blood slurry of its reduction in concentration of cortisol, the rising brain content of NE, 5-HT and metabolite 5-HIAA thereof relevant.
Technical background
The investigation of WHO shows, the sickness rate of depression is classified the 5th up to 10% as in the world's 10 big diseases, the sickness rate of domestic depression is 5.8%, about 5～20% people can suffer from depression a certain period in life, and depression will be one of the most serious disease of the 21 century mankind.Existing antidepressant Western medicine mainly is: tricyclic antidepressants (TCAs), selectivity 5-HT reuptake inhibitor (SSRIs), oxidase inhibitor (MAOIs), the toxic and side effects of their equal various degrees, and shortcoming such as cost an arm and a leg.Thereby the new antidepressants of research and development have important theory and practical significance from Chinese medicine.
Theory of Chinese medical science is thought " The heart controls mental activities, excess of the heart is then liked, have a guilty conscience then sad ", and depressed and anxiety are all relevant with the mind, the motive, painstaking effort.Main Ingredients and Appearance in the Chinese medicine composition of our prescription therapeutic depression, anxiety neurosis " heart is pleased " is the more Chinese medicine (computer statistics analysis) of frequency of utilization in successive dynasties hundreds of compound recipes of calming the nerves, rational compatibility after ancient Chinese medicine long-term practice and modern expert are to pharmacodynamic study.Its prescription is followed the Therapeutic Principle of the traditional Chinese medical science about " emotional disorder " fully: " reinforcing the heart of nourishing blood, tranquilizing the mind, waking up the patient from unconsciousness by clearing away phlegm " and decide.The medicine that has benefiting qi and nourishing blood to calm the nerves in " heart please " side has heart-spleen boosting and the medicine of mind tranquilizing and the heart calming, and having eliminates the phlegm has one's ideas straightened out and the medicine of mind tranquilizing and the heart calming, happy hole is arranged and the medicine of mind tranquilizing and the heart calming, and this prescription has embodied Chinese medicine compound multi-level, many target spots of curing the disease, inherent relevant characteristics.
Summary of the invention
The present invention disclose first the compositions of Radix Ginseng, Poria, Rhizoma Acori Graminei, Radix Polygalae and active component combination thereof be used for the treatment of the doctor trained in Western medicine category based on depressed, the mental sickness of anxiety symptom and the feelings will disease of traditional Chinese medical science category.
Can be according to the preparation process of routine, excipient substances such as conventional excipient, flavoring agent, disintegrating agent, antiseptic, lubricant, wetting agent, binding agent, solvent, thickening agent, solubilizing agent will be added after Radix Ginseng, Poria, Rhizoma Acori Graminei, the Radix Polygalae pulverizing medicinal materials, make any dosage form that is suitable for using clinically, as tablet, capsule, granule, oral liquid, injection etc.
Radix Ginseng, Poria, Rhizoma Acori Graminei, Radix Polygalae can be obtained each active constituents of medicine through extracting, concentrate, making with extra care, promptly ginsenoside, pachyman, Rhizoma Acori Graminei volatile ingredient/involatile constituent, polygalic acid are or/and polysaccharide is made above-mentioned any dosage form after forming compositions.
Below will the invention will be further described by concrete example
Antidepressant effect and the study on mechanism thereof of embodiment 1 " heart is pleased "
1 material and method
1.1 the animal Kunming mouse is male, body weight 18～22g.Providing by Military Medical Science Institute's Experimental Animal Center. each organizes mice all under the same conditions, freely drinks water, ingests, keeps natural light.
1.2 medicine Radix Ginseng, Poria, Rhizoma Acori Graminei, Radix Polygalae (3: 3: 2: 2) all available from PLA General Hospital Chinese medicine pharmacy, soak 30min after, decoct 30min, twice merging filtrate is condensed into every 1ml and contains the 1g crude drug, 4 ℃ of refrigerators are preserved.Positive drug DESIPRAMINE (SIGMA company, lot number: 200-373-1).The hydrocortisone test kit is provided by the East Asia immunity.Standard substance: norepinephrine (Norepinephrine, NE, Sigma company, lot number; 200-095-0); Dopamine (Dopamine, DA, Sigma company, lot number: 200-527-8) 5-hydroxy tryptamine (5-hydroxytryptamine, 5-HT, Sigma company, lot number: 153-98-0); 5-hydroxyindoleacetic acid (5-hydrooxyindole-3-aceticacid, 5-HIAA, Sigma company, lot number: 200-195-4) trisodium citrate; Perchloric acid (Beijing chemical reagent work, analytical pure); Methanol (Beijing chemical reagent work, chromatographically pure); Water is the experiment ultra-pure water.
13 instruments, 1050 type high performance liquid chromatographs (U.S. Hewlett-Packard); 1046 type fluorescence detectors (U.S. Hewlett-Packard); Bondapar Phenyl chromatographic column (U.S. waters company); The 15R refrigerated centrifuge (U.S. Heraeus biofuge) that exceeds the speed limit.
2 experimental techniques
2.1 the mandatory swimming test of mice
2.1.1 experiment grouping and administration: it is administration 1 day, 3 days, 5 days, 7 days, 14 days district's groups that mice is distinguished component at random, and each district's group is divided into matched group at random, positive controls, ' heart is pleased ' high, medium and low dosage group.Matched group is given and normal saline 0.2ml/20g, and positive controls is given and Desipramine 0.2mg/20g, and high, medium and low dosage group is given and crude drug 0.12ml/20g, 0.06ml/20g, 0.03ml/20g.Each group is irritated stomach, 1 time/day.
2.1.2 the mensuration of mice dead time: each district group mice carries out the forced swimming experiment behind the successive administration last.Mice is put into high 20cm, in the glass beaker of diameter 10cm, the dark 10cm of water in the cup, water temperature 25 ℃ ± 1,1 in each beaker begins behind the 2min to observe, and observes to continue 4min, mice dead time (stop to struggle or apparent floating state, the persistent period of tiny limb motion to keep head to keep afloat only arranged) in water in this 4min of accumulative total.
2.2 hydrocortisone assay: mice after the swimming is extractd eyeball and gets blood, (5000rmin-1) centrifugal 5min at a high speed, and separation of serum is put-70 ℃ of refrigerators and is preserved to be measured.Adopt radio immunoassay (RIA) to measure hydrocortisone content, the operating procedure by specification carries out [2].
2.3 the mensuration of central neurotransmitter
Collection of specimens and processing: each district group mice carries out the forced swimming experiment behind the successive administration last, sacrificed by decapitation mice after swimming finishes, head is placed on the ice platform, rapidly brain is taken out, place liquid nitrogen container, after leave in-78 ℃ of cryogenic refrigerators, treat that whole sample collections fully after, carry out the mensuration of neurotransmitter.Test was taken out cerebral tissue and add the ice-cold 0.1mol/L HCLO4 of 0.5ml the same day, operates in ice bath with glass homogenizer, and 4 ℃, the centrifugal 30min of 15000g, the taking-up supernatant, recentrifuge 10min gets supernatant, direct injected 50 μ l.
Chromatographic condition: mobile phase is the 20mmol/L trisodium citrate, and regulating PH with Hcl is 5.0, adds the methanol of 5% (V/V) behind the membrane filtration of 0.45 μ m, and through ultrasonic degas, flow velocity is 1.0ml/min before using.The fluorescence detector wavelength is set to: excitation wavelength (EM) 280nm, emission wavelength (EX) 315nm; With peak area quantification.
The preparation of standard substance and the preparation of standard curve: precision takes by weighing NE, DA, 5-HT, 5-HIAA, places the 10ml volumetric flask respectively, adds 0.1mol/lHCLO
4To scale, shake up.Get NE131ug/ml, DA 127 μ g/ml, 5-HT 111 μ g/ml, 5-HIAA 107 μ g/ml standard solution respectively.Get above-mentioned standard solution and get NE, DA, 5-HT, 5-HIAA series concentration respectively through dilution preparation standard curve.Area under curve behind the sample introduction (Y) returns concentration (X).
2.4 the statistical method experimental result is used the SPSS statistical software, adopts variance analysis, group difference carries out with the T check, and gained is the result represent with x ± S.
3. result
3.1 ' heart is pleased ' is to the influence of the mandatory swimming of mice
Table 1 " heart please " is to the influence of the mandatory swimming of mice (X ± S)
The mandatory non-swimming time of mice (s)
Group n 1 day 3 days 5 days 7 days 14 days
High dose group 10 57.7 ± 21.9
*94.5 ± 17.7 72.8 ± 22.4 62.6 ± 21.1
*102.7 ± 35.7
Middle dosage group 10 38.0 ± 28.9
*69.4 ± 24.4
*58.4 ± 29.4
*57.5 ± 29.5
*74.3 ± 12.1
*
Low dose group 10 87.9 ± 12.9
*97.0 ± 31.8 96.9 ± 19.3 67.0 ± 19.8
*112.3 ± 22.9
Positive drug group 10 29.3 ± 9.7
*44.7 ± 20.6
*58.0 ± 22.6
*55.0 ± 23.3
*48.7 ± 23.0
*
Matched group 10 94.6 ± 18.6 108.7 ± 24.3 114.8 ± 27.9 139.9 ± 28.5 132.3 ± 13.0
*Compare P＜0.05 with matched group
*Compare P＜0.01 with matched group
3.2 " heart is pleased " is to the influence of mice plasma hydrocortisone
Table 2 " heart please " is to the influence of mice plasma hydrocortisone content (X ± S)
N hydrocortisone content (ng/ml)
1 day 3 days 5 days 7 days 14 days
Normal group 10 15.8 ± 2.4 13.9 ± 3.3 16.4 ± 6.5 13.6 ± 4.1 14.9 ± 5.7
Matched group 10 69.3 ± 9.2
##56.6 ± 15.1
##61.4 ± 5.3
##53.7 ± 7.4
##58.4 ± 17.7
##
Positive controls 10 44.9 ± 5.2
##53.3 ± 5.3
##56.6 ± 9.7
##54.1 ± 5.7
##49.7 ± 9.1
##
High dose group 10 54.3 ± 8.0
##56.3 ± 6.7
##47.0 ± 7.6
* ##32.2 ± 8.1
* ##47.3 ± 6.2
##
Middle dosage group 10 46.9 ± 3.1
* ##48.5 ± 9.4
##50.1 ± 2.9
##29.8 ± 6.3
* ##30.3 ± 6.7
* ##
Low dose group 10 41.3 ± 2.0
* ##56.5 ± 5.2
##61.8 ± 7.7
##52.5 ± 12.8
##53.3 ± 9.0
##
*Compare P＜0.05 with matched group
##Compare P＜0.01 with normal group
3.2 " heart is pleased " is to the influence of neurotransmitter in the mouse brain
Table 3 " heart is pleased " different dosing time depression model mice central neurotransmitter NE content (μ g/g wet tissue)
Administration administration in 1 day administration in 3 days administration in 5 days administration in 7 days 14 days
Negative control group (n=6) 0.69 ± 0.03 0.76 ± 0.03 0.91 ± 0.01 0.51 ± 0.07 0.82 ± 0.06
Positive controls (n=6) 0.70 ± 0.06 1.10 ± 0.01
*1.35 ± 0.01
*1.25 ± 0.02
*1.25 ± 0.01
*
High dose group (n=6) 0.70 ± 0.03 0.74 ± 0.03 1.06 ± 0.02
*0.68 ± 0.08 0.88 ± 0.06
Middle dosage group (n=6) 0.71 ± 0.05 0.95 ± 0.06
*0.94 ± 0.13 0.68 ± 0.05 0.89 ± 0.02
Low dose group (n=6) 0.77 ± 0.01 0.90 ± 0.13 1.09 ± 0.02
*0.83 ± 0.13
*0.86 ± 0.19
Table 4 " heart is pleased " different dosing time depression model mice central neurotransmitter DA content (μ g/g wet tissue)
Administration administration in 1 day administration in 3 days administration in 5 days administration in 7 days 14 days
Negative control group (n=6) 0.96 ± 0.01 0.98 ± 0.14 1.05 ± 0.07 0.84 ± 0.13 1.10 ± 0.05
Positive controls (n=6) 0.95 ± 0.06 0.94 ± 0.01 1.09 ± 0.01 0.96 ± 0.02 1.06 ± 0.01
High dose group (n=6) 1.00 ± 0.07 0.93 ± 0.01 1.30 ± 0.11 0.98 ± 0.11 1.10 ± 0.03
Middle dosage group (n=6) 1.49 ± 0.68 1.17 ± 0.17 1.14 ± 0.03 0.93 ± 0.01 1.09 ± 0.10
Low dose group (n=6) 0.95 ± 0.06 1.39 ± 0.41 1.23 ± 0.01 1.02 ± 0.06 1.03 ± 0.22
Table 5 " heart is pleased " different dosing time depression model mice central neurotransmitter 5-HT content (μ g/g wet tissue)
Administration administration in 1 day administration in 3 days administration in 5 days administration in 7 days 14 days
Negative control group (n=6) 1.43 ± 0.05 3.49 ± 0.45 3.07 ± 0.11 1.29 ± 0.15 1.41 ± 0.04
Positive controls (n=6) 1.73 ± 0.07
*1.82 ± 0.01
*1.65 ± 0.01
*1.92 ± 0.02
*1.85 ± 0.01
*
High dose group (n=6) 1.53 ± 0.08 3.22 ± 0.06
*3.35 ± 0.36 1.74 ± 0.03
*1.72 ± 0.06
*
Middle dosage group (n=6) 1.47 ± 0.07 3.51 ± 0.41 2.73 ± 0.31 1.50 ± 0.10
*1.58 ± 0.01
*
Low dose group (n=6) 1.36 ± 0.01 3.82 ± 0.43 2.98 ± 0.18 1.74 ± 0.24
*1.51 ± 0.07
Table 6 " heart is pleased " different dosing time depression model mice central neurotransmitter 5-HIAA content (μ g/g wet tissue)
Administration administration in 1 day administration in 3 days administration in 5 days administration 14 in 7 days is big
Negative control group (n=6) 0.16 ± 0.06 0.28 ± 0.12 0.26 ± 0.05 0.39 ± 0.08 0.32 ± 0.01
Positive controls (n=6) 0.11 ± 0.01 0.30 ± 0.01 0.24 ± 0.01 0.28 ± 0.02 0.35 ± 0.01
High dose group (n=6) 0.11 ± 0.01 0.39 ± 0.01 0.44 ± 0.08
*0.40 ± 0.01 0.38 ± 0.06
Middle dosage group (n=6) 0.21 ± 0.16 0.53 ± 0.12
*0.34 ± 0.01
*0.40 ± 0.01 0.42 ± 0.02
*
Low dose group (n=6) 0.28 ± 0.06
*0.49 ± 0.06
*0.51 ± 0.01
*0.56 ± 0.04* 0.53 ± 0.04
*
Table 7 " heart is pleased " different dosing time depression model mice central neurotransmitter 5-HT/5-HIAA ratio
Administration administration in 1 day administration in 3 days administration in 5 days administration in 7 days 14 days
Negative control group (n=6) 8.94 ± 0.08 12.46 ± 0.38 11.80 ± 0.94 3.31 ± 0.65 4.41 ± 0.96
Positive controls (n=6) 15.72 ± 0.14 6.06 ± 0.77 6.88 ± 0.28 6.85 ± 0.34 5.29 ± 0.14
High dose group (n=6) 13.9 ± 0.56
*8.26 ± 0.41
*7.61 ± 0.09
*4.35 ± 0.52 4.53 ± 0.37
Middle dosage group (n=6) 7 ± 0.19
*6.62 ± 0.67
*8.03 ± 0.35
*3.75 ± 0.18 3.76 ± 0.71
Low dose group (n=6) 4.86 ± 0.21
*7.8 ± 0.34
*5.84 ± 0.24
*3.1 ± 0.45 2.85 ± 0.65
4. conclusion
A kind of stable, reliable, classical depression model---forced swimming model is adopted in this experiment, the antidepressant effect of having investigated " heart is pleased " carries out Study on mechanism simultaneously, measures " heart is pleased " influence to monoamine neurotransmitter content in depression model mice plasma hydrocortisone content and the brain.The result shows that " heart is pleased " each dosage group all can shorten the dead time during the mandatory swimming of mice in various degree, has compared significant statistical significance with matched group.Prompting " heart is pleased " is similar to clinical antidepressant Western medicine desipramine (positive control drug) effect, the effect with tangible antidepressant and anxiety, but desipramine has significant side effects, and " heart is pleased " is without any side effects.
It is generally acknowledged, the content of depressed generation and the interior neurotransmitter of brain such as dopamine, 5-hydroxy tryptamine, norepinephrine is relevant, present studies show that, the cerebrospinal fluid of depressive patients, blood plasma and urocortisol raise, can not suppress hydrocortisone (7) in the blood with dexamethasone, the prompting depression also raises with hydrocortisone substantial connection." heart is pleased " influence to monoamine neurotransmitter content in depression model mice plasma hydrocortisone content and the brain has been measured in this research, the result shows, " heart is pleased " can reduce hydrocortisone content in the depressed animal blood slurry, the content of mouse brain interior NE, 5-HT and metabolite 5-HIAA thereof is raise, and the ratio of 5-HT/5-HIAA is on a declining curve, and prompting " heart is pleased " has activation to 5-HT neuron in the mouse brain.
In sum, our Chinese medicine of being made up of Radix Ginseng, Poria, Rhizoma Acori Graminei, Radix Polygalae that studies show that has tangible antidepressant effect, in its antidepressant effect and the depressed animal blood slurry of its reduction in concentration of cortisol, the rising brain content of NE, 5-HT and metabolite 5-HIAA thereof relevant.
Embodiment 2 hearts are pleased the depressed clinical impression of treatment and are observed
1, diagnostic criteria
Object is from the Neurology Department psychology consultation clinic, and we adopt Zung self-appraisal depression scale (SDS) and self-appraisal depressive symptom self-appraisal scale (Wakefield table), and evaluation once before administration.Secondary cases depression person due to the eliminating physical disease is as the object of observation.The same evaluation table of reuse is evaluated once after the administration, and clinical efficacy is by 4 grades of evaluations.
The patient has 16 examples, male's 11 examples, and women's 5 examples, 21～52 years old age, the people of schooling junior middle schools 4,3 people of senior middle school, above 9 people of junior college do blood, routine urinalysis, liver, renal function and Electrocardioscopy before the treatment.
2, method:
After seeking advice from, patient promptly stops using other antidepressant drug 7 days, take " heart is pleased " water decoction (Radix Ginseng 1-9g, Poria 3-12g, stone Chang 1-6g, Radix Polygalae 0.5-2g) then, 1 dose of decoction day takes 2 times, take medicine and carry out Zung self-appraisal depression scale (SDS) and Self-Rating Anxiety Scale (SAS) scoring after 4 weeks, and do blood, routine urinalysis, liver, renal function and Electrocardioscopy.
3, therapeutic outcome
Recovery from illness: mental symptom all disappears, and emotion is optimistic, and insight recovers; Produce effects: mental symptom disappears substantially, and insight is most of to be recovered; Effectively: mental symptom is improved substantially, and insight partly recovers; Invalid: mental symptom does not have improvement.Among the 16 routine patients, 11 examples of fully recovering, produce effects 3 examples, effective 1 example, invalid 1 example; Obvious effective rate 87.5%, effective percentage 93.8%.
The scale scoring:
SDS scoring: be 45.92 ± 3.9 before the treatment; Treatment back 35.43 ± 9.33, the scoring of treatment back significantly descends; Wakefield shows scoring: being 23.68 ± 5.72 before the treatment, is 13.55 ± 3.95 after the treatment, and the scoring of treatment back significantly descends.
Untoward reaction
After taking medicine, the patient do not see obvious adverse reaction.
Model case:
The patient * * *, man, 20 years old, the sophomore, during senior middle school and the classmate quarrel and fight noisily after head collided, headache, giddy appear, nervous, insomnia, suspect own head angiorrhexis, occur anorexia, depressed, school grade decline then, row Zung self-appraisal depression scale (SDS) scoring 45 minutes, nervous system and the internal medicine no abnormality seen of having a medical check-up, every inspections such as Cranial Computed Tomography inspection, electrocardio, brain electricity are all normal, got rid of organic disease, and clinical diagnosis is a depression.Take " heart please " water decoction, take 2 times 1 dose of decoction day, take medicine 4 week the back above-mentioned symptoms obviously alleviate, carrying out Zung self-appraisal depression scale (SDS) scoring is 23 minutes, depressive symptom is obviously alleviated, and carries out blood, routine urinalysis, liver, renal function and Electrocardioscopy no abnormality seen.
4, discuss
At present, clinically had multiple effective antidepressant, still, still had 1/3 patient effect very undesirable approximately, and it is obvious to take toxic and side effects for a long time.For example, effective although desipramine is treated depression clinically, tangible asthenia also appears, calm and cholinolytic activity side effect such as (causing xerostomia, forgetful).Therefore, seek antidepressant imperative novel, low toxicity.Based on Chinese medicine compound clinical experience in thousand and its homogeneity of curing the disease and globality, Chinese medicine compound may have unique antidepressant effect.
Theory of Chinese medical science is thought " The heart controls mental activities, excess of the heart is then liked, have a guilty conscience then sad ", and depressed and anxiety are all relevant with the mind, the motive, painstaking effort." heart please " prescription is followed the Therapeutic Principle of the traditional Chinese medical science about " emotional disorder " fully: " reinforcing the heart of nourishing blood, tranquilizing the mind, waking up the patient from unconsciousness by clearing away phlegm " and decide.The medicine that has benefiting qi and nourishing blood to calm the nerves in " heart please " side has heart-spleen boosting and the medicine of mind tranquilizing and the heart calming, and having eliminates the phlegm has one's ideas straightened out and the medicine of mind tranquilizing and the heart calming, happy hole is arranged and the medicine of mind tranquilizing and the heart calming, and this prescription has embodied Chinese medicine compound multi-level, many target spots of curing the disease, inherent relevant characteristics.
This clinical experiment adopts Zung self-appraisal depression scale to investigate the antidepressant effect of " heart is pleased ".The result shows that depression, anxiety symptom that " heart is pleased " causes for a variety of causes have obvious effects, and without any side effects.
Claims (4)
1. one kind to the Chinese medicine composition depressed, that anxiety symptom has remarkable therapeutical effect " heart is pleased ", it is characterized in that being made by the raw material of following parts by weight: (ratio is 3: 3: 2: 2 or 3: 5: 6: 2) for Radix Ginseng, Poria, Rhizoma Acori Graminei, Radix Polygalae.
2. Chinese medicine composition according to claim 1 comprises the compositions " heart is pleased " that the chemical analysis such as saponin in volatile oil, alkaloid and the Radix Polygalae in Radix Ginseng total saponins (comprising each monomer saponin), pachyman, the Rhizoma Acori Graminei are formed.
3. according to claim 1 and the described Chinese medicine composition of claim 2, be meant excipient substances such as adding conventional excipient, flavoring agent, disintegrating agent, antiseptic, lubricant, wetting agent, binding agent, solvent, thickening agent, solubilizing agent, make any dosage form that is suitable for using clinically, as tablet, capsule, granule, oral liquid, injection etc.
4. application according to claim 1, wherein the depression of indication, anxiety symptom are meant because anxiety, the depressive symptom (the strongly fragrant disease of the feelings will disease traditional Chinese medical science that comprises traditional Chinese medical science category) that a variety of causes causes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02148620 CN1241599C (en) | 2002-11-13 | 2002-11-13 | Traditional Chinese medicine composition for blahs and anxiety |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02148620 CN1241599C (en) | 2002-11-13 | 2002-11-13 | Traditional Chinese medicine composition for blahs and anxiety |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1500509A true CN1500509A (en) | 2004-06-02 |
| CN1241599C CN1241599C (en) | 2006-02-15 |
Family
ID=34233225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02148620 Expired - Fee Related CN1241599C (en) | 2002-11-13 | 2002-11-13 | Traditional Chinese medicine composition for blahs and anxiety |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1241599C (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100387293C (en) * | 2005-04-22 | 2008-05-14 | 高学敏 | Medicine composition and preparing method |
| CN102119986A (en) * | 2011-03-07 | 2011-07-13 | 北京中医药大学 | Traditional Chinese medicine extract with anti-dementia effect and preparation method thereof |
| CN102188466A (en) * | 2011-04-15 | 2011-09-21 | 电子科技大学 | Novel anti-depression compound preparation |
| CN103609936A (en) * | 2013-11-18 | 2014-03-05 | 无限极（中国）有限公司 | Application of acorus gramineus polysaccharide in preparing healthcare food having neuroprotective effect |
| CN105192195A (en) * | 2014-11-27 | 2015-12-30 | 青岛申达高新技术开发有限公司 | Anti-fatigue eleutherococcus senticosus health tea and preparation method thereof |
| CN105412843A (en) * | 2015-12-30 | 2016-03-23 | 南京中医药大学 | Traditional Chinese medicine composition capable of enhancing memory and relieving depression, preparation method and applications thereof |
| CN105663506A (en) * | 2016-03-01 | 2016-06-15 | 南京中医药大学 | Traditional Chinese medicine extract with anti-depression effect and application thereof |
| CN105664044A (en) * | 2016-03-03 | 2016-06-15 | 吉林省通化博祥药业股份有限公司 | Traditional Chinese medicine combined extract with anti-depression effect as well as preparation method and application thereof |
| CN107737207A (en) * | 2017-11-30 | 2018-02-27 | 山西中医药大学 | Pharmaceutical composition with antidepressant effect and its production and use |
| CN109820932A (en) * | 2019-01-25 | 2019-05-31 | 沈阳药科大学 | A kind of Chinese medicine standard decoction for preventing and treating senile dementia |
| CN110623969A (en) * | 2019-09-05 | 2019-12-31 | 河北中医学院 | Component formula for treating amnesia |
| CN112336796A (en) * | 2019-08-06 | 2021-02-09 | 中国科学院烟台海岸带研究所 | Pharmaceutical composition with effects of relieving anxiety and improving depression and application thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101168024B (en) * | 2007-10-25 | 2010-12-01 | 北京星昊医药股份有限公司 | Proprietary Chinese medicine for treating depression and production method thereof |
-
2002
- 2002-11-13 CN CN 02148620 patent/CN1241599C/en not_active Expired - Fee Related
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100387293C (en) * | 2005-04-22 | 2008-05-14 | 高学敏 | Medicine composition and preparing method |
| CN102119986A (en) * | 2011-03-07 | 2011-07-13 | 北京中医药大学 | Traditional Chinese medicine extract with anti-dementia effect and preparation method thereof |
| CN102119986B (en) * | 2011-03-07 | 2013-03-27 | 北京中医药大学 | Traditional Chinese medicine extract with anti-dementia effect and preparation method thereof |
| CN102188466A (en) * | 2011-04-15 | 2011-09-21 | 电子科技大学 | Novel anti-depression compound preparation |
| CN103609936A (en) * | 2013-11-18 | 2014-03-05 | 无限极（中国）有限公司 | Application of acorus gramineus polysaccharide in preparing healthcare food having neuroprotective effect |
| CN103609936B (en) * | 2013-11-18 | 2015-12-30 | 无限极（中国）有限公司 | Grass-leaved sweetflag polysaccharide is preparing the application had in the health food of neuroprotection |
| CN105192195A (en) * | 2014-11-27 | 2015-12-30 | 青岛申达高新技术开发有限公司 | Anti-fatigue eleutherococcus senticosus health tea and preparation method thereof |
| CN105412843B (en) * | 2015-12-30 | 2019-07-16 | 南京中医药大学 | Remember with enhancing, improves the Chinese medicine composition and the preparation method and application thereof of depressive emotion effect |
| CN105412843A (en) * | 2015-12-30 | 2016-03-23 | 南京中医药大学 | Traditional Chinese medicine composition capable of enhancing memory and relieving depression, preparation method and applications thereof |
| CN105663506A (en) * | 2016-03-01 | 2016-06-15 | 南京中医药大学 | Traditional Chinese medicine extract with anti-depression effect and application thereof |
| CN105664044A (en) * | 2016-03-03 | 2016-06-15 | 吉林省通化博祥药业股份有限公司 | Traditional Chinese medicine combined extract with anti-depression effect as well as preparation method and application thereof |
| CN107737207A (en) * | 2017-11-30 | 2018-02-27 | 山西中医药大学 | Pharmaceutical composition with antidepressant effect and its production and use |
| CN107737207B (en) * | 2017-11-30 | 2020-09-11 | 山西中医药大学 | Pharmaceutical composition with antidepressant effect and preparation method and application thereof |
| CN109820932A (en) * | 2019-01-25 | 2019-05-31 | 沈阳药科大学 | A kind of Chinese medicine standard decoction for preventing and treating senile dementia |
| CN112336796A (en) * | 2019-08-06 | 2021-02-09 | 中国科学院烟台海岸带研究所 | Pharmaceutical composition with effects of relieving anxiety and improving depression and application thereof |
| CN110623969A (en) * | 2019-09-05 | 2019-12-31 | 河北中医学院 | Component formula for treating amnesia |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1241599C (en) | 2006-02-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1241599C (en) | Traditional Chinese medicine composition for blahs and anxiety | |
| CN1965966A (en) | Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases, preparation method and application thereof | |
| CN101337034B (en) | Oral traditional Chinese preparation for treating craniocerebral injury syndrome and preparation method thereof | |
| CN1698804A (en) | Chinese medicinal preparation for treating qi obstruction in chest and heart palpitation and its preparation process | |
| CN1872214A (en) | Application of medication composition of containing notoperygium root in preparing medication for treating chronic insufficiency of supplying blood for brain | |
| CN1704113A (en) | Chinese traditional medicinal preparation containing red sange root and safflower for treating cardiovascular and cerebrovascular diseases and preparing process thereof | |
| CN1663599A (en) | Improved plaster for treating rheumatic and rheumatoid diseases and preparation method thereof | |
| CN1186067C (en) | Medicine for curing acute injury of muscle and tendon and its preparation method | |
| CN1241611C (en) | Medicine for treating hypertension and its preparing process | |
| CN101700264B (en) | Application of pseudo-ginseng and extract thereof in preparing medicament for curing and/or preventing diabetic neuropathies | |
| CN1919252A (en) | Medicine for treating cardiovascular and cerebrovascular disease | |
| CN1415303A (en) | Red sage root and Tienchi sustained release medication, its preparation method and medicinal application in vascular dementia | |
| CN1250278C (en) | Oral medicine for treating dementia and feeblemindedpess | |
| CN108567753A (en) | All beam dripping pill and its preparation process | |
| CN102988505B (en) | Medicine composition for treating erectile dysfunction and preparation method thereof | |
| CN1453029A (en) | Chinese medicine composition for treating senile dementia | |
| CN1582946A (en) | Use of centellosic acid derivative in preparation of medicines for diseases of cardio-cerebral blood vessels | |
| CN1772753A (en) | Chinese medicine active compound component for treating senile dementia and its prepn and use | |
| CN1872291A (en) | Application of medication composition of containing uncaria in preparing medicine for treating insufficiency of blood supply for brain | |
| CN1872276A (en) | Application of medication composition of containing extractive of astragalus root in preparing medicine for treating insufficiency of blood supply for brain | |
| CN1305493C (en) | Chinese medicine effective part for treating cerebral apoplexy and its separation preparing process | |
| CN1919237A (en) | Medicine for treating cardiovascular and cerebrovascular diseases | |
| CN1919235A (en) | Cardiac and cerebral vascular disease treating pharmaceutical composition | |
| CN1233359C (en) | Compound Jigucao capsule (Abrus fruticulosus Wall. ex Wight et Arn.) and its prodn. method | |
| CN1596960A (en) | Traditional Chinese medicine for treating brain arteria induration |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20060215 Termination date: 20171113 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |