CN105663508A - Medicine composition for treating echinococcosis of animals and preparation method thereof - Google Patents

Abstract

The invention provides a medicine composition for treating echinococcosis of animals. The composition is prepared from the following components in parts by weight: 15-45 parts of radix aconiti, 5-20 parts of przewalskia tangutica, 10-40 parts of rhododendron spanotrichum, 5-20 parts of fructus chebulae, 3-15 parts of acorus calamus, 2-15 parts of radix aucklandiae, 2-15 parts of synthetic musk, 2-15 parts of embelia laeta and 5-25 parts of safflower. The composition is natural in source, and is safe and environment-friendly. The invention further provides a tablet prepared from the composition and a preparation method thereof. The preparation method comprises the steps of pretreatment, grinding and crushing, granulating, tabletting and the like. The method is simple, is easy to implement, and can be used for improving the bioavailability of the medicine composition. The invention also provides application of the medicine composition in treatment of echinococcosis of animals.

Description

A kind of pharmaceutical composition for treating animal echinococcosis and preparation method thereof

Technical field

The present invention relates to pharmaceutical field, in particular to a kind of pharmaceutical composition for treating animal echinococcosis and preparation method thereof.

Background technology

Tibet is one of big pastoral area of China five, and animal husbandry is Tibet mainstay of the national economy industry. Owing to Tibet is vast in territory, high mountain landforms physical features is complicated, various miniclimate wide variety, and temperature Change is complicated, and domestic animal is put in a suitable place to breed on a large scale in addition, causes cattle and sheep parasite species many, and Distribution is extensive. Secondly, the anti-system of parasitic disease in Animal husbandry production is backward in technique, particularly in the outlying local area with animal husbandry for Main Economic basis and economic condition difference, " autumn is fertile, the winter is thin, the spring is dead " of domestic animal is very prominent, some are that endemoepidemic infecting both domestic animals and human parasitic disease is still serious, even endanger or threaten the healthy or even life security of local common people. Showing according to related data, Tibet domestic animal endoparasite and ectoparasite kind reaches 186 kinds so far, and advantage worm kind reaches more than 60 kinds, and wherein cattle and sheep brain Echinococcus hydatid cyst, gastrointestinal nematode and ectoparasitic infection rate are high, and infection intensity is big. If the infection rate of Yak calf cerebral echinococcosis is up to 9.63%, show with anti-data processed according to the investigation of Tibet animal epidemic again, the multiple parasitic disease of domestic animal severe infections in current Tibet 30%, morbidity head number accounts for the 25% of stock, and mortality rate is about the 2～3% of stock. 3rd, along with the defect of the disabling of anti-brain Echinococcus hydatid cyst related chemistry medicine and Western medicine self, the family's livestock products meat caused, milk yield reduce, produces hair, and to reduce the economic loss brought very huge. Cattle and sheep cerebral echinococcosis has not only severely impacted the normal growth of cattle and sheep and growth makes the quality of its product, quantity decline, inefficiencies, and the popular of serious cerebral echinococcosis more causes large quantities of cattle and sheep expendable death childhood, causes huge economic loss to Tibet livestock culturing industry.

In recent years, along with taking place frequently of many animal food safety problems such as residue of veterinary drug, chemicals abuse, find human and animal and ecological environment had low toxicity, low-residual, environmentally friendly efficient natural medicine have become research field and the direction of novel chiral synthon, Tibetan medicine is because its existence is in high and cold ecological environment, rich in unique active component, not only there is the medicinal efficacy of many mysteries, and there is the features such as noresidue, drug effect be strong and lasting.

The present invention anti-Brain of The Yak echinococcosis folk remedy of tradition, and the genuine Tibetan medicine material in folk remedy is carried out rational proportion, it is preferable that go out a kind of anti-brain Echinococcus hydatid cyst Tibetan medicine prescription based on plant medicine. This anti-brain Echinococcus hydatid cyst Tibetan veterinary medicine formula based on Radix aconiti szechenyiani, Tangut Przewalskia, Stigma Croci sativi Cuculus polioephalus, Fructus Chebulae, Rhizoma Acori Calami, the Radix Aucklandiae, artificial Moschus, Fructus embeliae laetae, Flos Carthami, this Tibetan medicine prescription and preparation thereof can provide steadily lasting valid density and toxic and side effects not easily occur, it is effectively accomplished the effect of long-term treatment and prevention, by the prevention and control ability improving Tibet cattle and sheep cerebral echinococcosis is promoted preventing and treating verminosis technology further, China's animal husbandry development is had important practical significance.

Summary of the invention

The first object of the present invention is in that to provide a kind of pharmaceutical composition for treating animal echinococcosis, described pharmaceutical composition low toxicity, low-residual, environmental friendliness.

The second object of the present invention is in that to provide a kind of tablet using described pharmaceutical composition to prepare, and described tablet can provide steadily lasting valid density and toxic and side effects not easily occurs.

The third object of the present invention is in that the preparation method providing a kind of described tablet, and described method makes genuine Tibetan medicine histiocyte sporoderm-broken rate high, thus being conducive to release and the absorption of medicine, being conducive to increasing drug absorption rate, improving its bioavailability.

The fourth object of the present invention is in that the application providing described pharmaceutical composition in treatment animal echinococcosis.

In order to realize the above-mentioned purpose of the present invention, spy by the following technical solutions:

One aspect of the present invention relates to a kind of pharmaceutical composition for treating animal echinococcosis, and described compositions includes following component by weight: Radix aconiti szechenyiani 15～45 parts, Tangut Przewalskia 5～20 parts, Stigma Croci sativi Cuculus polioephalus 10～40 parts, Fructus Chebulae 5～20 parts, Rhizoma Acori Calami 3～15 parts, the Radix Aucklandiae 2～15 parts, artificial Moschus 2～15 parts, Fructus embeliae laetae 2～15 parts, Flos Carthami 5～25 parts.

Above medical material is genuine Tibetan medicine, and its raw material sources are natural, and composition is safe, green, side effect is little, and after mixing according to proportioning provided by the invention, the various active composition in medical material complements each other, play the effect of Synergistic between its component, preventing and treating animal echinococcosis is played significant effect.

Preferably, described compositions includes following component by weight: Radix aconiti szechenyiani 20～30 parts, Tangut Przewalskia 10～15 parts, Stigma Croci sativi Cuculus polioephalus 20～30 parts, Fructus Chebulae 5～10 parts, Rhizoma Acori Calami 6～10 parts, the Radix Aucklandiae 5～10 parts, artificial Moschus 5～10 parts, Fructus embeliae laetae 5～10 parts, Flos Carthami 10～15 parts.

Another aspect of the present invention relates to a kind of tablet, drug powder mixture that the above-mentioned pharmaceutical composition of its component grinds to form and pharmaceutically acceptable adjuvant, wherein said adjuvant includes maltose, Petiolus Trachycarpi oil, citric acid, malic acid, sodium bicarbonate and Semen avenae nudae starch.

The adjuvant added is healthy and safe composition, its preparation being combined with being beneficial to pharmaceutical composition, and can produce cooperative effect between adjuvant and drug powder, improves, promotes the curative effect of pharmaceutical composition.

Preferably, by weight, described tablet mainly includes following components: 20～30 parts of described drug powder mixture, maltose 1～3 part, Petiolus Trachycarpi oil 0.2～0.5 part, citric acid 8～12 parts, malic acid 5～10 parts, sodium bicarbonate 15～20 parts, Semen avenae nudae starch 10～20 parts.

Active constituents of medicine in the present invention is the micropowder that Tibetan medicine medical material is made, and mix ingredients is complicated, is not easily absorbed in vivo. For this, the invention provides the effervescent tablet of a kind of specific component, this effervescent tablet effectively solves the shortcoming that Tibetan medicine disintegration rate in gastro-intestinal Fluid is slow, onset is slow. The tablet of the present invention, disintegration time only needs 2 minutes, and does not make the disintegrate in gastro-intestinal Fluid of this Tibetan medicine of effervescent tablet and need about 20 minutes.

The preparation method of the tablet described in another aspect of the present invention, said method comprising the steps of:

Radix aconiti szechenyiani 15～45 parts, Tangut Przewalskia 5～20 parts, Stigma Croci sativi Cuculus polioephalus 10～40 parts, Fructus Chebulae 5～20 parts, Rhizoma Acori Calami 3～15 parts, the Radix Aucklandiae 2～15 parts, artificial Moschus 2～15 parts, Fructus embeliae laetae 2～15 parts, Flos Carthami 5～25 parts.

1) pretreatment Radix aconiti szechenyiani, Tangut Przewalskia, Stigma Croci sativi Cuculus polioephalus, Fructus Chebulae, Rhizoma Acori Calami, the Radix Aucklandiae, artificial Moschus, Fructus embeliae laetae and Flos Carthami, and it is ground into microgranule, mixing, form drug powder mixture;

2) described drug powder mixture is placed in mixer, adds Petiolus Trachycarpi oil, citric acid, malic acid and maltose soft material;

3) described medicine soft material is made granule and dried;

4) by described granule and starch mixing, tabletting is carried out.

Pharmaceutical composition is carried out the attrition grinding of cell grade by this method, Tibetan medicine histiocyte sporoderm-broken rate can be made to improve, thus being conducive to release and the absorption of medicine, be conducive to increasing drug absorption rate, improve its bioavailability, reduce dosage, conservation, improve efficiency, reduce cost, the homogenization of each effective ingredient in being conducive to compound recipe Tibetan medicine to pulverize, improve the action effect of medicine, Crushing of Ultrafine can carry out at different temperatures, it has and is beneficial to reservation bioactive ingredients, applied widely, powder distribution is uniform, take mouthfeel good, it is prone to molding, it is easy to the features such as application.

Preferably, step 1) described in its granularity of drug powder mixture be 150-200 order.

In the method for the present invention, Tibetan medicine raw material is carried out the attrition grinding of cell grade so that it is particle diameter is little to 150 orders, so can improve its absorbance and bioavailability.

Preferably, in step 3) in by described granule by 8～10 mesh sieve 3 times, again through 13～15 mesh sieve 2 times.

Preferably, described step 3) in, dry granule at the temperature of 50～60 DEG C.

According to the design parameter processed mixture provided in above method for optimizing, prepare tablet, it is possible to farthest improve the bioavailability of medicine.

Another aspect of the present invention relates to the application in treatment animal echinococcosis of the described pharmaceutical composition.

Treatment animal echinococcosis is had outstanding curative effect by the pharmaceutical composition of the present invention.

Preferably, described animal echinococcosis is cattle echinococcosis.

Compared with prior art, the invention have the benefit that

(1) medicine material is natural Tibetan medicine, is easy to get, safety and environmental protection;

(2) treatment animal echinococcosis is had fabulous curative effect by the pharmaceutical composition of the present invention, and the tablet of the present invention can provide drug disposition valid density in long lasting and stable ground;

(3) preparation method of the present invention is convenient to carry out, and by being carried out by Tibetan medicine, cell grade is other to be ground so that its bioavailability is greatly improved for it.

(4) pharmaceutical composition of the present invention has wide range of applications, and is particularly well-suited to the preventing and treating of cattle echinococcosis.

Detailed description of the invention

Below in conjunction with embodiment, embodiment of the present invention are described in detail, it will be appreciated by those skilled in the art that the following example is merely to illustrate the present invention, and are not construed as restriction the scope of the present invention. Unreceipted actual conditions person in embodiment, conventionally the condition of condition or manufacturer's suggestion carries out. Agents useful for same or the unreceipted production firm person of instrument, be and can pass through the commercially available conventional products bought and obtain.

Embodiment 1

Tablet is prepared according to following steps:

1) pretreatment Radix aconiti szechenyiani by weight 45 parts, Tangut Przewalskia 20 parts, Stigma Croci sativi Cuculus polioephalus 40 parts, Fructus Chebulae 20 parts, Rhizoma Acori Calami 15 parts, the Radix Aucklandiae 15 parts, artificial Moschus 15 parts, Fructus embeliae laetae 15 parts and Flos Carthami 25 parts, and it is ground into microgranule, mixing, forming drug powder mixture, Tibetan medicine superfine powder granularity is 150 orders;

2) being placed in trough type mixing machine by the material of mixing, take its 20 parts and add Petiolus Trachycarpi oil 0.2 part, citric acid 8 parts, malic acid 5 parts and maltose 1 part, mixing treats that bulk formed by material, forms soft material;

3) above-mentioned soft material shines by 3 times through 8～10 orders, and 13～15 mesh sieves pass through 2 times, makes granule, and dry at 50 DEG C;

4) in dried granule, add starch, by various composition mix homogeneously, pinch with hands to make a good job of and scatter for degree;

5) tabletting is carried out.

Embodiment 2

Tablet is prepared according to following steps:

1) pretreatment Radix aconiti szechenyiani by weight 15 parts, Tangut Przewalskia 5 parts, Stigma Croci sativi Cuculus polioephalus 10 parts, Fructus Chebulae 5 parts, Rhizoma Acori Calami 3 parts, the Radix Aucklandiae 2 parts, artificial Moschus 2 parts, Fructus embeliae laetae 2 parts and Flos Carthami 5 parts, and it is ground into microgranule, mixing, forming drug powder mixture, Tibetan medicine superfine powder granularity is 150 orders;

2) being placed in trough type mixing machine by the material of mixing, take its 30 parts and add Petiolus Trachycarpi oil 0.5 part, citric acid 12 parts, malic acid 10 parts and maltose 3 parts, mixing treats that bulk formed by material, forms soft material;

3) above-mentioned soft material shines by 3 times through 8～10 orders, and 13～15 mesh sieves pass through 2 times, makes granule, and dry at 60 DEG C;

4) in dried granule, add starch, by various composition mix homogeneously, pinch with hands to make a good job of and scatter for degree;

5) tabletting is carried out.

Experimental example 3

Tablet is prepared according to following steps:

1) pretreatment Radix aconiti szechenyiani by weight 20 parts, Tangut Przewalskia 10 parts, Stigma Croci sativi Cuculus polioephalus 20 parts, Fructus Chebulae 5 parts, Rhizoma Acori Calami 6 parts, the Radix Aucklandiae 5 parts, artificial Moschus 5 parts, Fructus embeliae laetae 5 parts and Flos Carthami 10 parts, and it is ground into microgranule, mixing, forming drug powder mixture, Tibetan medicine superfine powder granularity is 150 orders;

2) being placed in trough type mixing machine by the material of mixing, take its 20 parts and add Petiolus Trachycarpi oil 0.4 part, citric acid 10 parts, malic acid 8 parts and maltose 2 parts, mixing treats that bulk formed by material, forms soft material;

3) above-mentioned soft material shines by 3 times through 8～10 orders, and 13～15 mesh sieves pass through 2 times, makes granule, and dry at 50 DEG C;

4) in dried granule, add starch, by various composition mix homogeneously, pinch with hands to make a good job of and scatter for degree;

5) tabletting is carried out.

Embodiment 4

Tablet is prepared according to following steps:

1) pretreatment Radix aconiti szechenyiani by weight 30 parts, Tangut Przewalskia 15 parts, Stigma Croci sativi Cuculus polioephalus 30 parts, Fructus Chebulae 10 parts, Rhizoma Acori Calami 10 parts, the Radix Aucklandiae 10 parts, artificial Moschus 10 parts, Fructus embeliae laetae 10 parts and Flos Carthami 15 parts, and it is ground into microgranule, mixing, forming drug powder mixture, Tibetan medicine superfine powder granularity is 150 orders;

2) being placed in trough type mixing machine by the material of mixing, take its 30 parts and add Petiolus Trachycarpi oil 0.5 part, citric acid 12 parts, malic acid 10 parts and maltose 3 parts, mixing treats that bulk formed by material, forms soft material;

3) above-mentioned soft material shines by 3 times through 8～10 orders, and 13～15 mesh sieves pass through 2 times, makes granule, and dry at 50 DEG C;

4) in dried granule, add starch, by various composition mix homogeneously, pinch with hands to make a good job of and scatter for degree;

5) tabletting is carried out.

Embodiment 5

Tablet is prepared according to following steps:

1) pretreatment Radix aconiti szechenyiani by weight 30 parts, Tangut Przewalskia 15 parts, Stigma Croci sativi Cuculus polioephalus 30 parts, Fructus Chebulae 10 parts, Rhizoma Acori Calami 10 parts, the Radix Aucklandiae 10 parts, artificial Moschus 10 parts, Fructus embeliae laetae 10 parts and Flos Carthami 15 parts, and it is ground into microgranule, mixing, forming drug powder mixture, Tibetan medicine superfine powder granularity is 150 orders;

2) being placed in trough type mixing machine by the material of mixing, take its 20 parts and add Petiolus Trachycarpi oil 0.5 part, citric acid 10 parts, malic acid 8 parts and maltose 2 parts, mixing treats that bulk formed by material, forms soft material;

3) above-mentioned soft material shines by 3 times through 8～10 orders, and 13～15 mesh sieves pass through 2 times, makes granule, and dry at 50 DEG C;

4) in dried granule, add starch, by various composition mix homogeneously, pinch with hands to make a good job of and scatter for degree;

5) tabletting is carried out.

Animal clinical study

Taking the cenurus cerebralis of yak brain, feed and pass through the doggie that anthelmintic processes, take every day Canis familiaris L. feces to carry out microscopy, if there being a large amount of worm's ovum to get rid of, after gathering feces in time, being saved in normal saline, feed healthy Yak calf.

Duplication successfully sick yak is divided into 6 groups, and often group 20, wherein 1-5 group uses the tablet of preparation, the 6th group of blank group being not use any medicament in embodiment 1-5 respectively. Above 6 groups of disease yaks carrying out the drug treatment of 28 days, observes and record its body weight change and recovery from illness situation, result is as shown in table 1.

Table 1 pharmacodynamic experiment statistical table

As can be seen from the above table, use the sick yak of the tablet in treatment of the present invention, after the treatment of 28 days, have the cure rate of more than 70%, and body weight increases to some extent. The sick yak of blank group then spontaneous recovery and average weight cannot reduce nearly 1kg. Therefore, the tablet of the present invention, to treatment cattle echinococcosis, has outstanding curative effect.

Observe the coenurus before and after treatment, it is possible to find on the coenurus cyst wall before treatment it is observed that many [Dans. The needle-like spinule of marshalling indistinctly be can be observed on nipple. In coenurus cephalomere, sucker is clear-cut, and rostellum central authorities have two rows to be arranged radially hook.

Cenurus cerebralis cyst wall atrophy after treatment, the nipple fracture on cyst wall, disappearance. In cephalomere, the original structure such as sucker thickens unclear because of downright bad, does not see any structure, and the little hook of rostellum of remaining is still visible, but irregular arrangement, experiment cattle Ureteral Calculus is after 28 days, after butchering cranial cavity and opening, it has been found that whole encapsulation flavescence capsule liquid reduces in calcification.

Although illustrate and describing the present invention with specific embodiment, however it will be appreciated that may be made that when without departing substantially from the spirit and scope of the present invention many other change and amendment. It is, therefore, intended that include all such changes and modifications belonging in the scope of the invention in the following claims.

Claims (10)

1., for treating a pharmaceutical composition for animal echinococcosis, described compositions includes following component by weight: Radix aconiti szechenyiani 15～45 parts, Tangut Przewalskia 5～20 parts, Stigma Croci sativi Cuculus polioephalus 10～40 parts, Fructus Chebulae 5～20 parts, Rhizoma Acori Calami 3～15 parts, the Radix Aucklandiae 2～15 parts, artificial Moschus 2～15 parts, Fructus embeliae laetae 2～15 parts, Flos Carthami 5～25 parts.

2. pharmaceutical composition according to claim 1, it is characterized in that, described compositions includes following component by weight: Radix aconiti szechenyiani 20～30 parts, Tangut Przewalskia 10～15 parts, Stigma Croci sativi Cuculus polioephalus 20～30 parts, Fructus Chebulae 5～10 parts, Rhizoma Acori Calami 6～10 parts, the Radix Aucklandiae 5～10 parts, artificial Moschus 5～10 parts, Fructus embeliae laetae 5～10 parts, Flos Carthami 10～15 parts.

3. tablet, described tablet includes drug powder mixture and the pharmaceutically acceptable adjuvant that the pharmaceutical composition described in claim 1 or 2 grinds to form, and wherein said adjuvant includes maltose, Petiolus Trachycarpi oil, citric acid, malic acid, sodium bicarbonate and Semen avenae nudae starch.

4. tablet according to claim 3, it is characterized in that, by weight, described tablet mainly includes following components: 20～30 parts of described drug powder mixture, maltose 1～3 part, Petiolus Trachycarpi oil 0.2～0.5 part, citric acid 8～12 parts, malic acid 5～10 parts, sodium bicarbonate 15～20 parts, Semen avenae nudae starch 10～20 parts.

5. the preparation technology of the tablet according to claim 3 or 4, described technique comprises the following steps:

1) pretreatment Radix aconiti szechenyiani, Tangut Przewalskia, Stigma Croci sativi Cuculus polioephalus, Fructus Chebulae, Rhizoma Acori Calami, the Radix Aucklandiae, artificial Moschus, Fructus embeliae laetae and Flos Carthami, and it is ground into microgranule, mixing, form drug powder mixture;

2) described drug powder mixture is placed in mixer, adds Petiolus Trachycarpi oil, citric acid, malic acid and maltose soft material;

3) described soft material made granule and dry;

4) by described granule and starch mixing, tabletting is carried out.

6. method according to claim 5, it is characterised in that step 1) described in the granularity of drug powder mixture be more than 150 orders, it is preferred that described granularity is more than 200 orders.

7. method according to claim 5, it is characterised in that in step 3) in by described granule by 8～10 mesh sieve 3 times, again through 13～15 mesh sieve 2 times.

8. method according to claim 5, it is characterised in that described step 3) in, dry granule at the temperature of 50～60 DEG C.

9. the application in treatment animal echinococcosis of the pharmaceutical composition described in claim 1 or 2.

10. application according to claim 9, it is characterised in that described animal echinococcosis is cattle echinococcosis.