CN102895546B - Chinese herbal medicine compound formula for preventing and treating apostichopus japonicus balantidiasis - Google Patents
Chinese herbal medicine compound formula for preventing and treating apostichopus japonicus balantidiasis Download PDFInfo
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- CN102895546B CN102895546B CN2012104109767A CN201210410976A CN102895546B CN 102895546 B CN102895546 B CN 102895546B CN 2012104109767 A CN2012104109767 A CN 2012104109767A CN 201210410976 A CN201210410976 A CN 201210410976A CN 102895546 B CN102895546 B CN 102895546B
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Abstract
The invention discloses a Chinese herbal medicine compound formula for preventing and treating apostichopus japonicus balantidiasis, belonging to the field of prevention and control of seawater cultivating diseases. The Chinese herbal medicine compound formula comprises the following components in percentage by mass: 40 percent of pumpkin seed, 30 percent of pomegranate peel, 20 percent of lightyellow sophora root, 5 percent of paris rhizome, 2 percent of green bristlegrass and 3 percent of Chinese gall, and is prepared by smashing the components, sieving with a 100-mesh sieve, and mixing uniformly. In a compatible medicinal composition, the pumpkin seed and the paris rhizome can be used for effectively killing ciliates in a cultivating environment, and the combination of the pomegranate peel and the lightyellow sophora root is easy for apostichopus japonicus to eat and absorb and can be used for killing ciliates hosting in apostichopus japonicus, so that the defect that ordinary pesticides are only suitable for body surface desinsection. The Chinese gall and the green bristlegrass can be used for effectively treating skin ulceration caused by ciliate infection, and perform synergic actions, so that a better treatment effect is achieved. The formula has a remarkable curative effect on apostichopus japonicus balantidiasis, and plays a very important role in increasing the survival rate of apostichopus japonicus cultivation and guaranteeing stable production and high yield of cultivation.
Description
Technical field
The invention belongs to sea-farming control and prevention of disease field, relate to particularly a kind of Chinese herbal medicine compound prescription of preventing and treating the Radix Morinae Bulleyanae balantidiasis.
Background technology
Radix Morinae Bulleyanae (Apostichopus japonicus) is the highest kind of economic worth in China Stichopus japonicus, and its geographical distribution is that China Liaodong Peninsula and the Shandong Peninsula, Russian east, Japan and Korea S are coastal.National Stichopus japonicus aquaculture area was approximately 150,000 hectares in 2010, and 130,000 tons of output, the output value surpass 20,000,000,000 yuan, become one of the highest kind of China's sea-farming single variety output value, with a very important position in inshore fishing economy.
Yet along with the expansion of cultivation scale, the Radix Morinae Bulleyanae disease occurs frequent, causes the economic loss of more than 30 hundred million yuan every year, and the disease problem has directly had influence on the sound development of aquaculture industry.The Radix Morinae Bulleyanae principal disease of having reported has bacterial disease, virosis and parasitic disease three major types.In management of parasitic diseases, the most serious with the harm of balantidiasis.The deutostoma worm is the ciliate of a kind of obligatory parasitism in the Radix Morinae Bulleyanae respiratory trees, can cause respiratory tissue damage and arrange dirty, the dirty rear forfeiture ingestion ability of Radix Morinae Bulleyanae row of severe infections, the ginseng body is become thin, vigor weakens, and easily by other cause of disease, causes secondary infection, and this disease is called as Radix Morinae Bulleyanae deutostoma parasitosis.This disease autumn and winter season incidence rate higher.Except the deutostoma worm, the shield ciliate is also to endanger larger a kind of parasite, and this disease is popular in 6 higher~July of water temperature in summer, incidence rate is the highest within seedling adheres to a week, harm is also maximum, easily causes acute death, and the mortality rate of part plant seedling is up to 90%.
Plant's treatment now and prevention Radix Morinae Bulleyanae ciliate disease are used chemosterilant, antibiotic more, and the life-time service of these medicines, make the quality safety of Radix Morinae Bulleyanae product be affected unavoidably.Yet, both at home and abroad the research of sea cucumber disease concentrated on bacterial disease, less to the research of balantidiasis, the researches of control Chinese herbal medicine.
Before the present invention forms, mainly concentrate in the research of the aspects such as epidemiology, nosetiology and histopathology about the ciliophoran report of Radix Morinae Bulleyanae, have no Chinese herbal medicine compound prescription patent and bibliographical information for the Radix Morinae Bulleyanae balantidiasis.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese herbal medicine compound prescription of preventing and treating the Radix Morinae Bulleyanae balantidiasis, can effectively treat and prevent the culturing stichopus japonicus balantidiasis.By using the medicine that this formula is made can reach to the culturing stichopus japonicus of suffering from fine parasitosis obvious therapeutic effect, significantly improve the cultivation survival rate, increase culture benefit.
The present invention realizes by following technical scheme:
The screening experiment flow process of medicine is: carry out Radix Morinae Bulleyanae balantidiasis Epidemiological study widely, grasp its epidemic; Collect sick ginseng sample and carry out that cause of disease is ciliophoranly separated, cultivation, evaluation and artificial resumption infection test to determine pathogenic former; Carrying out external medicine kills except test with screening of medicaments; Carrying out pharmaceutical formulation combination and clinical prevention effect test determines and optimization of C/C composites.
A kind of Chinese herbal medicine compound prescription composition and mass percent of preventing and treating the Radix Morinae Bulleyanae balantidiasis that the present invention forms is: Semen Cucurbitae 40%, and Pericarpium Granati 30%, Radix Sophorae Flavescentis 20%, Rhizoma Paridis 5%, Herba Setariae Viridis 2%, Galla Chinensis 3%, pulverize and sieve through 100 orders, mix homogeneously.
The invention provides a kind of using method of medicine of described Chinese herbal medicine compound prescription formation: oral, during prevention, addition is 1~2 gram/kilogram feedstuff, 6~10 grams/kilogram feedstuff during treatment.
The present invention also provides a kind of using method of medicine of described Chinese herbal medicine compound prescription formation: dipping, every cube of medicine that water body adds 15~20 described Chinese herbal medicine compound prescriptions of gram to form.
The present invention's beneficial effect compared with prior art:
1, the invention belongs to the Chinese herb compound of Radix Morinae Bulleyanae special use, use simple: only need in proportion medicine to be added in bait and makes pharmaceutical chemistry.
2, with low cost, be applicable to large water surface apostichopus japonicus culture production disease prevention.
3, during oral medication, the cure rate of this medicine can reach more than 70%.
4, Semen Cucurbitae, the Rhizoma Paridis in compatibe drug combination of the present invention can effectively kill except the ciliate in the apostichopus japonicus culture environment, Pericarpium Granati and Radix Sophorae Flavescentis compatibility are easy to by the Radix Morinae Bulleyanae absorption of ingesting, can kill the ciliate that colonizes in the Radix Morinae Bulleyanae body, overcome general insecticide and be only applicable to the defect of body surface parasite killing.Galla Chinensis and Herba Setariae Viridis can effectively be treated because ciliate infects the skin ulceration that causes, the performance synergism, make therapeutic effect better.
The specific embodiment
Below by embodiment, technical scheme of the present invention is further explained, but protection scope of the present invention is not subjected to any pro forma restriction of embodiment.
Embodiment:
During in January, 2009 to 2011 year December, this research in Qingdao, the ground morbidity apostichopus japonicus culture field men such as Weihai, Yantai, Rongcheng have carried out clinical trial, use Chinese herbal medicine compound prescription of the present invention: Semen Cucurbitae 40%, Pericarpium Granati 30%, Radix Sophorae Flavescentis 20%, Rhizoma Paridis 5%, Herba Setariae Viridis 2% and Galla Chinensis 3%, above each component by percentage to the quality, is pulverized and is sieved through 100 orders, mix homogeneously.
The actual therapeutic effect is in Table 1:
The clinical prevention effect of table 1 compound Chinese herb to the Radix Morinae Bulleyanae balantidiasis
Annotate: in this table, due to the commercial interest relation, the title inconvenience of test site man is open.
Prove by a large amount of control clinical trials, this Chinese herb compound has significant curative effect to the Radix Morinae Bulleyanae balantidiasis,, to improving the apostichopus japonicus culture survival rate, ensures that breeding production stable and high yields tool is of great significance.
Claims (1)
1. herbal composite of preventing and treating the Radix Morinae Bulleyanae balantidiasis is characterized in that its composition and mass percent are: Semen Cucurbitae 40%, and Pericarpium Granati 30%, Radix Sophorae Flavescentis 20%, Rhizoma Paridis 5%, Herba Setariae Viridis 2%, Galla Chinensis 3%, pulverize and sieve through 100 orders, mix homogeneously system.
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CN104738325A (en) * | 2013-12-26 | 2015-07-01 | 王宝燕 | Feed for juvenile sea cucumber |
CN104274543B (en) * | 2014-09-29 | 2016-07-06 | 浙江海洋学院 | A kind of medicine treating set balantidiasis |
Citations (2)
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CN102078549A (en) * | 2010-12-29 | 2011-06-01 | 辛如才 | Traditional Chinese medicine for treating oxyuriasis |
CN102578171A (en) * | 2012-01-11 | 2012-07-18 | 张彦斌 | Chinese herbal medicinal insecticide |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102078549A (en) * | 2010-12-29 | 2011-06-01 | 辛如才 | Traditional Chinese medicine for treating oxyuriasis |
CN102578171A (en) * | 2012-01-11 | 2012-07-18 | 张彦斌 | Chinese herbal medicinal insecticide |
Non-Patent Citations (4)
Title |
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中草药在水产养殖中应用的研究进展;邢跃楠等;《中国水产》;20070430(第04期);64-66 * |
中草药防治水产动物疾病及药理学研究进展;王海华;《中兽医学杂志》;20040831(第04期);37-41 * |
王海华.中草药防治水产动物疾病及药理学研究进展.《中兽医学杂志》.2004,(第04期), |
邢跃楠等.中草药在水产养殖中应用的研究进展.《中国水产》.2007,(第04期), |
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