CN105663431A - Medicine composition used for clinical anesthesia and preparation method thereof - Google Patents
Medicine composition used for clinical anesthesia and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a medicine composition and application thereof, in particular to a medicine composition used for clinical anesthesia and the application thereof. The medicine composition used for the clinical anesthesia and the application thereof belong to the technical field of medicine. The medicine active ingredients of the medicine composition are prepared from the following traditional Chinese drugs: fructus forsythia, ovate leaf Holly Bark, dandelion, moutan bark, hairyvein agrimony, tuckahoe, flos daturae, henbane and liquorice. The medicine composition has the advantages of convenience in use, safety, reliability, good anesthesia effect, small toxic and side effect of the medicine and wide medical application prospect when being used for the clinical anesthesia.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and purposes thereof, relate to a kind of pharmaceutical composition for clinical anesthesia and its preparation method specifically, belong to medical art.
Background technology
Anesthesia is exactly make patient's entirety or local temporarily lose sensation by medicine or additive method, to reach painless object, for operative treatment or other medical examination treatment offer condition, it is used in operation or first aid process, mainly comprises general anesthesia, toponarcosis and compound anesthesia. General anesthesia is current Application comparison a kind of anesthesia method widely, and a lot of doctor performs the operation in order to convenience or eliminates the feared state of mind of patient, more options general anesthesia. General anesthesia is generally that narcotic enters in body through approach such as suction, vein, muscle or rectum perfusions, makes patient realize disappearance, and pain is not felt on the whole body, and neural reflex and muscle activity have suppression in various degree. But at present doctor trained in Western medicine general anesthesia is not only costly, also there will be various side effect, more common have feel sick and vomiting, sleepy, temporarily cannot urine, headache etc. of having a sore throat; Other slighter complication comprises: myalgia, tooth, artificial tooth make lip, tongue expiratory dyspnea injured, temporary, parathria and nerve damage; Serious complication such as heart trouble outbreak, apoplexy, severe allergic reaction, permanent neurologic is impaired, eye injuries, larynx are impaired and pneumonia.
At present, Chinese medicine anesthesia has been applied to multiple operation, has easy to use, simple to operate, instant effect, long action time, amount of bleeding is few, the advantage that side effect is little, the operation that the time that is especially applicable to is longer, Chinese medicine general anesthesia decreases the trouble of doctor's repeatable operation tonic, medical matters people staff can be made to concentrate one's energy to execute art, and patient is easy to accept, solve by the feared states of mind such as " having a fainting spell during acupuncture treatment " and the operation midway not good misery brought of drug effect. Although Chinese medicine anesthesia have accumulated a large amount of practical experiences clinically, and played due effect in the certain period, but current Chinese medicine general anesthesia also exists a lot of deficiency, therefore develop curative effect more definite, it is possible to the new medicine anesthesia preparation widely used is necessary.
Summary of the invention
In order to solve the shortcoming in clinical application of existing anesthesia preparation, the present invention provides a kind of evident in efficacy, cheap, the little pharmaceutical composition of side effect is used for clinical anesthesia, its active constituents of medicine is made up of following traditional Chinese medicines: the capsule of weeping forsythia, Ilex rotunda Thunb., taraxacum, Tree Peony Bark, Herba Agrimoniae, Poria cocos, Hindu Datura Flower Hairy Datura Flower, Semen Hyoscyami, Radix Glycyrrhizae.
The primary efficacy of further each component is as follows:
The capsule of weeping forsythia is bitter, micro-cold.Return lung, the heart, small intestine warp. Clearing heat and detoxicating, dispersing swelling and dissipating binds. For ulcer, scrofula pestilence, acute mastitis, erysipelas, common cold due to wind-heat, warm disease from the beginning of, warm join the army, high hot polydipsia, coma sends out spot, and heat drenches renal shutdown.
Ilex rotunda Thunb. is bitter, cool. Clearing heat and detoxicating, swelling and pain relieving. For flu, tonsillitis, swelling and pain in the throat, acute gastroenteritis, treating rheumatic ostealgia; Wound is controlled in external application, carbuncle furuncle sore, traumatic hemorrhage, burn and scald.
Taraxacum, bitter, sweet, cold. Return liver, stomach warp. Clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome. For furuncle swelling toxin, acute mastitis, scrofula pestilence, hot eyes, pharyngalgia, lung carbuncle, acute appendicitis, jaundice due to damp-heat, heat drenches puckery pain.
Tree Peony Bark, bitter, pungent, micro-cold. The thoughts of returning home, liver, kidney channel. Clearing heat and cooling blood, promoting blood circulation and removing blood stasis. For maculae caused by violent heat pathogen, hematemesis and epistaxis, night, heat was early cool, and lossless hectic fever due to yin, through closing dysmenorrhoea, carbuncle sore tumefacting virus, falls and flutter the pain of injury.
Herba Agrimoniae, bitter, puckery, flat. The thoughts of returning home, Liver Channel. Astringing to arrest bleeding, preventing malaria, only dysentery, removing toxic substances. For hemoptysis, spitting blood, metrostaxis, malaria, bloody flux, de-power internal lesion caused by overexertion, carbuncle sore tumefacting virus, under pruritus vulvae band.
Poria cocos is sweet, light, flat. The thoughts of returning home, lung, spleen, kidney channel. Promoting diuresis to eliminate damp pathogen, the strong peaceful heart of spleen. Few for oedema urine, phlegm and retained fluid is dizzy throbs with fear, and insufficiency of the spleen food is few, has loose bowels in loose stool, confused and worried, palpitation with fear insomnia.
Hindu Datura Flower Hairy Datura Flower, pungent, temperature; Poisonous. Return lung, Liver Channel. Antiasthmatic-antitussive, analgesia, spasmolysis. For asthma and cough, coldness and pain in the epigastrium, rheumatic arthralgia, children's shies slowly; Surgical anesthesia.
Semen Hyoscyami, bitter, pungent, temperature; Very toxic. There is the effect of spasmolysis, pain relieving, worm of calming the nerves, kill. Controlling demented, wind, wandering arthritis is fainted bitterly, breathes with cough, stomachache, and dysentery of a specified duration, rushes down for a long time, prolapse of the anus, toothache, and carbuncle swells, and dislikes sore.
Radix Glycyrrhizae, sweet, flat. The thoughts of returning home, lung, spleen, stomach warp. Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription. For weakness of the spleen and the stomach, fatigue and weakness, shortness of breath and palpitation, coughing with a lot of sputum, the anxious pain of gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
One of the object of the invention is to provide a kind of pharmaceutical composition for clinical anesthesia. Pharmaceutical composition prescription of the present invention is rigorous, and compatibility is reasonable, and ingredients interacts, and plays clearing heat and detoxicating altogether, and analgesia anesthesia, cooling blood for hemostasis, the special effect of tranquillizing by calming the heart, achieves unexpected excellent effect for clinical anesthesia. Experiment proves, drug combination can strengthen the result for the treatment of of medicine, reduces adverse drug reaction.
Based on this, the weight proportion of pharmaceutical composition each component of the present invention is: capsule of weeping forsythia 10-16 part, Ilex rotunda Thunb. 12-18 part, taraxacum 6-14 part, Tree Peony Bark 6-14 part, Herba Agrimoniae 8-16 part, Poria cocos 6-14 part, Hindu Datura Flower Hairy Datura Flower 3-7 part, Semen Hyoscyami 6-12 part, Radix Glycyrrhizae 10-18 part.
Preferably capsule of weeping forsythia 12-14 part, Ilex rotunda Thunb. 14-16 part, taraxacum 9-11 part, Tree Peony Bark 9-11 part, Herba Agrimoniae 12-14 part, Poria cocos 9-11 part, Hindu Datura Flower Hairy Datura Flower 4-6 part, Semen Hyoscyami 8-10 part, Radix Glycyrrhizae 13-15 part.
Most preferably, the weight part number of each Chinese medicine of described pharmaceutical composition is: the capsule of weeping forsythia 13 parts, Ilex rotunda Thunb. 15 parts, taraxacum 10 parts, Tree Peony Bark 10 parts, Herba Agrimoniae 13 parts, 10 parts, Poria cocos, Hindu Datura Flower Hairy Datura Flower 5 parts, Semen Hyoscyami 9 parts, 14 parts, Radix Glycyrrhizae.
Present invention also offers the preparation method of described pharmaceutical composition activeconstituents, specifically comprise following steps: get each medicinal material, pulverize into meal respectively; Add water temperature and soak 4 hours, decoct and boil twice, each 2.5 hours, merge decoction liquor, filter;Filtrate concentrate to relative density when 80 DEG C be 1.11~1.15 clear cream, slowly add ethanol when being chilled to 40 DEG C, make alcohol content reach 75%, stir evenly, leave standstill 12 hours, filter, reclaim ethanol to without alcohol taste, filtrate adds appropriate amount of auxiliary materials, and technique is prepared into corresponding formulation routinely.
Pharmaceutical composition for clinical anesthesia of the present invention, it is possible to select suitable route of administration according to the state of an illness and pharmaceutical properties, such as enema, mixture, decoction, tablet, capsule, oral liquid etc., it is preferable to enema.
Based on the pharmacodynamics embodiment of the present invention, the present invention also asks protection aforementioned pharmaceutical compositions for the purposes in clinical anesthesia. Rectal administration it is preferably during aforementioned pharmaceutical compositions administration. As shown in clinical observation of the present invention test, it can be seen that: pharmaceutical composition of the present invention has positive analgesia effect. It is embodied in: test a group has significant difference respectively compared with test b-d group, significant synergy is there is in this after showing each component compatibility of pharmaceutical composition of the present invention, not only significantly strengthen in drug use effect, and untoward reaction is little, safety coefficient height, is conducive to clinical application.
Embodiment
Below by way of specific embodiment, the present invention is described further; but those skilled in the art should know specific embodiments of the invention and not limit the present invention in any way, and any equivalent replacement done on basis of the present invention all falls into protection scope of the present invention.
Embodiment 1 enema of the present invention and its preparation method
Preparation technology is as follows:
In prescription, the weight part number of each Chinese medicine is: the capsule of weeping forsythia 13 parts, Ilex rotunda Thunb. 15 parts, taraxacum 10 parts, Tree Peony Bark 10 parts, Herba Agrimoniae 13 parts, 10 parts, Poria cocos, Hindu Datura Flower Hairy Datura Flower 5 parts, Semen Hyoscyami 9 parts, 14 parts, Radix Glycyrrhizae.
Get each medicinal material of recipe quantity, pulverize into meal respectively; Add water temperature and soak 4 hours, decoct and boil twice, each 2.5 hours, merge decoction liquor, filter; Filtrate concentrate to relative density when 80 DEG C be 1.11~1.15 clear cream, slowly add ethanol when being chilled to 40 DEG C, make alcohol content reach 75%, stir evenly, leave standstill 12 hours, filter, reclaim ethanol to without alcohol taste, filtrate adds appropriate amount of auxiliary materials, filtrate concentrates, filling and sealing, sterilizing and get final product.
Embodiment 2 mixture of the present invention and its preparation method
Preparation technology is as follows:
In prescription, the weight part number of each Chinese medicine is: the capsule of weeping forsythia 13 parts, Ilex rotunda Thunb. 15 parts, taraxacum 10 parts, Tree Peony Bark 10 parts, Herba Agrimoniae 13 parts, 10 parts, Poria cocos, Hindu Datura Flower Hairy Datura Flower 5 parts, Semen Hyoscyami 9 parts, 14 parts, Radix Glycyrrhizae.
Get each medicinal material of recipe quantity, pulverize into meal respectively; Add water temperature and soak 4 hours, decoct and boil twice, each 2.5 hours, merge decoction liquor, filter; Filtrate concentrate to relative density when 80 DEG C be 1.11~1.15 clear cream, slowly add ethanol when being chilled to 40 DEG C, make alcohol content reach 75%, stir evenly, leave standstill 12 hours, filter, reclaim ethanol to without alcohol taste, filtrate adds appropriate amount of auxiliary materials, and technique is prepared into mixture routinely.
Embodiment 3 oral solution of the present invention and its preparation method
Preparation technology is as follows:
In prescription, the weight part number of each Chinese medicine is: the capsule of weeping forsythia 13 parts, Ilex rotunda Thunb. 15 parts, taraxacum 10 parts, Tree Peony Bark 10 parts, Herba Agrimoniae 13 parts, 10 parts, Poria cocos, Hindu Datura Flower Hairy Datura Flower 5 parts, Semen Hyoscyami 9 parts, 14 parts, Radix Glycyrrhizae.
Get each medicinal material of recipe quantity, pulverize into meal respectively; Add water temperature and soak 4 hours, decoct and boil twice, each 2.5 hours, merge decoction liquor, filter; Filtrate concentrate to relative density when 80 DEG C be 1.11~1.15 clear cream, slowly add ethanol when being chilled to 40 DEG C, make alcohol content reach 75%, stir evenly, leave standstill 12 hours, filter, reclaim ethanol to without alcohol taste, filtrate adds appropriate amount of auxiliary materials, and technique is prepared into oral solution routinely.
Embodiment 4 enema of the present invention and its preparation method
Preparation technology is as follows:
In prescription, the weight part number of each Chinese medicine is: the capsule of weeping forsythia 12 parts, Ilex rotunda Thunb. 14 parts, taraxacum 9 parts, Tree Peony Bark 9 parts, Herba Agrimoniae 12 parts, 9 parts, Poria cocos, Hindu Datura Flower Hairy Datura Flower 4 parts, Semen Hyoscyami 8 parts, 13 parts, Radix Glycyrrhizae.
Get each medicinal material of recipe quantity, pulverize into meal respectively; Add water temperature and soak 4 hours, decoct and boil twice, each 2.5 hours, merge decoction liquor, filter; Filtrate concentrate to relative density when 80 DEG C be 1.11~1.15 clear cream, slowly add ethanol when being chilled to 40 DEG C, make alcohol content reach 75%, stir evenly, leave standstill 12 hours, filter, reclaim ethanol to without alcohol taste, filtrate adds appropriate amount of auxiliary materials, filtrate concentrates, filling and sealing, sterilizing and get final product.
Embodiment 5 enema of the present invention and its preparation method
Preparation technology is as follows:
In prescription, the weight part number of each Chinese medicine is: the capsule of weeping forsythia 14 parts, Ilex rotunda Thunb. 16 parts, taraxacum 11 parts, Tree Peony Bark 11 parts, Herba Agrimoniae 14 parts, 11 parts, Poria cocos, Hindu Datura Flower Hairy Datura Flower 6 parts, Semen Hyoscyami 10 parts, 15 parts, Radix Glycyrrhizae.
Get each medicinal material of recipe quantity, pulverize into meal respectively; Add water temperature and soak 4 hours, decoct and boil twice, each 2.5 hours, merge decoction liquor, filter; Filtrate concentrate to relative density when 80 DEG C be 1.11~1.15 clear cream, slowly add ethanol when being chilled to 40 DEG C, make alcohol content reach 75%, stir evenly, leave standstill 12 hours, filter, reclaim ethanol to without alcohol taste, filtrate adds appropriate amount of auxiliary materials, filtrate concentrates, filling and sealing, sterilizing and get final product.
Comparative example 1 enema and its preparation method
Preparation technology is as follows:
In prescription, the weight part number of each Chinese medicine is: the capsule of weeping forsythia 5 parts, Ilex rotunda Thunb. 15 parts, taraxacum 10 parts, Tree Peony Bark 10 parts, Herba Agrimoniae 13 parts, 10 parts, Poria cocos, Hindu Datura Flower Hairy Datura Flower 10 parts, Semen Hyoscyami 9 parts, 14 parts, Radix Glycyrrhizae.
Get each medicinal material of recipe quantity, pulverize into meal respectively; Add water temperature and soak 4 hours, decoct and boil twice, each 2.5 hours, merge decoction liquor, filter; Filtrate concentrate to relative density when 80 DEG C be 1.11~1.15 clear cream, slowly add ethanol when being chilled to 40 DEG C, make alcohol content reach 75%, stir evenly, leave standstill 12 hours, filter, reclaim ethanol to without alcohol taste, filtrate adds appropriate amount of auxiliary materials, filtrate concentrates, filling and sealing, sterilizing and get final product.
Comparative example 2 enema and its preparation method
Preparation technology is as follows:
In prescription, the weight part number of each Chinese medicine is: the coptis 13 parts, Ilex rotunda Thunb. 15 parts, taraxacum 10 parts, Tree Peony Bark 10 parts, Herba Agrimoniae 13 parts, 10 parts, Poria cocos, Hindu Datura Flower Hairy Datura Flower 5 parts, 14 parts, Radix Glycyrrhizae.
Get each medicinal material of recipe quantity, pulverize into meal respectively; Add water temperature and soak 4 hours, decoct and boil twice, each 2.5 hours, merge decoction liquor, filter; Filtrate concentrate to relative density when 80 DEG C be 1.11~1.15 clear cream, slowly add ethanol when being chilled to 40 DEG C, make alcohol content reach 75%, stir evenly, leave standstill 12 hours, filter, reclaim ethanol to without alcohol taste, filtrate adds appropriate amount of auxiliary materials, filtrate concentrates, filling and sealing, sterilizing and get final product.
The clinical observation test of pharmaceutical composition of the present invention
1. physical data:
Select patient 160 example needing to carry out operative treatment in anesthesiology department of hospital, patient is divided into test a, b, c, d tetra-groups at random, often organizes 40 examples, wherein tests a group man 22 example, female 18 example; Year at age 16-58, year mean age (33.2 ± 1.12), operating time 1.8h-7h, average 3.2h; Test b group man 25 example, female 15 example; Year at age 17-59, year mean age (31.5 ± 1.160), operating time 1.7h-7.2h, average 3.3h;Test c group man 24 example, female 16 example; Year at age 15-55, year mean age (32.0 ± 1.14), operating time 2.0h-6.8h, average 3.1h; Test d group man 23 example, female 17 example; Year at age 15-56, year mean age (32.5 ± 1.18), operating time 1.5h-7.5h, average 3.4h; Four groups of sexes, age, the state of an illness, operating times etc. compare, and difference there are no significant meaning (P > 0.05), has comparability.
2. medicament selection:
Test a group: use enema prepared by embodiment 1, every bag of 20ml, containing crude drug amount 2.5g, selects medicine amount according to operating time length and size, and minor operation, the time is shorter than 3h's, it may also be useful to one bag, major operation, and the time is greater than 3h, with two bags.
Test b group: use enema prepared by comparative example 1, every bag of 20ml, containing crude drug amount 2.5g, selects medicine amount according to operating time length and size, and minor operation, the time is shorter than 3h's, it may also be useful to one bag, major operation, and the time is greater than 3h, with two bags.
Test c group: use enema prepared by comparative example 2, every bag of 20ml, containing crude drug amount 2.5g, selects medicine amount according to operating time length and size, and minor operation, the time is shorter than 3h's, it may also be useful to one bag, major operation, and the time is greater than 3h, with two bags.
Test d group: using Disoprofol, intravenous injection, chooses drug dose by patient age, by specification uses.
3. criterion of therapeutical effect:
(1) effective: painless in surgical procedure, patient's nerve consciousness is without impact;
(2) effective: in art, pain has and alleviates sense, and patient's nerve consciousness has certain influence;
(3) invalid: without obviously anaesthetizing reaction, in surgical procedure, pain is strong, and patient's nerve consciousness is affected completely.
Always there is efficiency=(effective+effective)/total number of cases × 100%.
5. statistical method
With statistics software SPSS20.0, data being carried out statistical analysis, enumeration data adopts x2Inspection; Measurement data is with all counting ± standard deviationRepresent, carry out t inspection; P < 0.05 represents that between two groups, otherness is remarkable.
6. treatment result
1) the concrete treatment result testing each group is as shown in table 1.
Table 1: four groups for the treatment of clinical effectiveness
Group | n | Effective | Effectively | Invalid | There is efficiency |
Test a group | 40 | 28 | 11 | 1 | 97.5%* ◎ & |
Test b group | 40 | 11 | 17 | 12 | 70% |
Test c group | 40 | 12 | 18 | 10 | 75% |
Test d group | 40 | 10 | 17 | 13 | 67.5% |
Note: test a group compares with test b group,*P < 0.05; Compare with test c group,◎P < 0.05; Compare with test b group,&P < 0.05.
As can be seen from table 1 compares, clinical effective 28 people (obvious effective rate 70%) in test a group, always there is efficiency 97.5%, all it is better than other test group, and significant difference, there is statistical significance (P < 0.05), though respectively group curative effect is variant for other, but not there is statistical significance (P > 0.05), the clinical effectiveness particularly testing b, c group shows, arbitrarily change formula and proportioning, the result for the treatment of of the present invention can not be reached completely.
To sum up, the present invention provides a kind of Chinese medicine composition and its preparation method, and this Chinese medicine composition prescription is rigorous, and compatibility is reasonable, ingredients interacts, and plays clearing heat and detoxicating altogether, analgesia anesthesia, cooling blood for hemostasis, the special effect of tranquillizing by calming the heart, achieves unexpected excellent effect for clinical anesthesia. And test in a group anaesthesia process vital sign steadily and without serious adverse reactions such as allergy, the lab index routine blood test of test a group patient, routine urinalysis, electrocardiogram(ECG etc. are observed after terminating by treatment, show no obvious abnormalities.Result shows that the present invention is for easy to use, safe and reliable during clinical anesthesia, and anaesthetic effect is good, and poisonous side effect of medicine is little, has wide medical use prospect, is worth clinical expansion to use.
Claims (7)
1. the pharmaceutical composition for clinical anesthesia, it is characterised in that, described pharmaceutical composition is made up of following traditional Chinese medicines: the capsule of weeping forsythia, Ilex rotunda Thunb., taraxacum, Tree Peony Bark, Herba Agrimoniae, Poria cocos, Hindu Datura Flower Hairy Datura Flower, Semen Hyoscyami, Radix Glycyrrhizae.
2. pharmaceutical composition as claimed in claim 1, it is characterized in that, in described pharmaceutical composition, the weight part number of each main Chinese medicine is: capsule of weeping forsythia 10-16 part, Ilex rotunda Thunb. 12-18 part, taraxacum 6-14 part, Tree Peony Bark 6-14 part, Herba Agrimoniae 8-16 part, Poria cocos 6-14 part, Hindu Datura Flower Hairy Datura Flower 3-7 part, Semen Hyoscyami 6-12 part, Radix Glycyrrhizae 10-18 part.
3. pharmaceutical composition as claimed in claim 1, it is characterized in that, the weight part number of each main Chinese medicine of described pharmaceutical composition is: capsule of weeping forsythia 12-14 part, Ilex rotunda Thunb. 14-16 part, taraxacum 9-11 part, Tree Peony Bark 9-11 part, Herba Agrimoniae 12-14 part, Poria cocos 9-11 part, Hindu Datura Flower Hairy Datura Flower 4-6 part, Semen Hyoscyami 8-10 part, Radix Glycyrrhizae 13-15 part.
4. pharmaceutical composition as claimed in claim 1, it is characterised in that, the weight part number of each main Chinese medicine of described pharmaceutical composition is: the capsule of weeping forsythia 13 parts, Ilex rotunda Thunb. 15 parts, taraxacum 10 parts, Tree Peony Bark 10 parts, Herba Agrimoniae 13 parts, 10 parts, Poria cocos, Hindu Datura Flower Hairy Datura Flower 5 parts, Semen Hyoscyami 9 parts, 14 parts, Radix Glycyrrhizae.
5. pharmaceutical composition as described in claim 1-4, it is characterised in that, described pharmaceutical composition can be enema, mixture, decoction, tablet, capsule or oral liquid.
6. pharmaceutical composition as claimed in claim 5, it is characterised in that, described preparation is preferably enema.
7. pharmaceutical composition described in claim 1-4 is for the preparation of the purposes in the medicine of clinical anesthesia.
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Citations (2)
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CN104491166A (en) * | 2014-12-30 | 2015-04-08 | 青岛市肿瘤医院 | Traditional Chinese medicine composition with auxiliary anesthetic effect |
CN105326952A (en) * | 2015-12-16 | 2016-02-17 | 青岛麦瑞特医药技术有限公司 | Medicine composition for treating acute cholecystitis |
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CN104491166A (en) * | 2014-12-30 | 2015-04-08 | 青岛市肿瘤医院 | Traditional Chinese medicine composition with auxiliary anesthetic effect |
CN105326952A (en) * | 2015-12-16 | 2016-02-17 | 青岛麦瑞特医药技术有限公司 | Medicine composition for treating acute cholecystitis |
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