CN105663198A - Medicine for treating burn and preparation method thereof - Google Patents
Medicine for treating burn and preparation method thereof Download PDFInfo
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- CN105663198A CN105663198A CN201610149735.XA CN201610149735A CN105663198A CN 105663198 A CN105663198 A CN 105663198A CN 201610149735 A CN201610149735 A CN 201610149735A CN 105663198 A CN105663198 A CN 105663198A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses medicine for treating a burn and a preparation method thereof. The medicine is mainly prepared from climbing groundsel herb and broadleaf holly leaves. The prepared medicine has the effects of clearing away heat and toxic materials, relieving pain and promoting granulation and can effectively treat the burn, a scald and the like.
Description
Invention field:
The present invention relates to a kind of medicine and its preparation method for the treatment of burn, belong to the field of medicine technology.
Technical background:
Burn is due to the caused tissue injury such as heat, chemical substance, optical, electrical and radioactive rays, mainly refer to skin and (or) mucous membrane, severe patient can injure subcutis, such as muscle, bone, joint even internal organ, is a kind of extremely complicated traumatic disease. There is the four problemses such as surface of a wound pain, Progressive symmetric erythrokeratodermia necrosis, easy infection, scar healing. The medicine for the treatment of burn and scald is divided into Chinese medicine and Western medicine, and the treatment of each comfortable burn and scald all there has been considerable progress. The therapeutic action of burn and scald is anti-inflammatory by Western medicine, anti-infection, myogenic, promotes wound healing, promotes epithelial growth etc. The infection of prophylactic treatment burn wound, anti-inflammatory, antibacterial, what application was more at present is antibiotics.
In treatment burn, scald, types of medicines and methods for the treatment of are more at present, expose for small-area burn is most with the coating such as paste, ingredients or partly expose treatment, and these method weak points are at weak curative effect, and the course for the treatment of is long, and painful big, remained scar ratio height, cost is big.
Summary of the invention:
It is an object of the invention to provide a kind of medicine and its preparation method for the treatment of burn. Described medicine has clearing heat and detoxicating, pain relieving, effect of myogenic, can effectively treat burn, scald etc.
For solving above technical problem, the present invention realizes by the following technical solutions: a kind of medicine treating burn, according to listed as parts by weight, makes primarily of squaw weed 10-50 part, Leaf of Chinese Holly 10-50 part and auxiliary material.
In the medicine of aforementioned therapies burn, according to listed as parts by weight, make primarily of squaw weed 20-40 part, Leaf of Chinese Holly 20-40 part and auxiliary material.
In the medicine of aforementioned therapies burn, according to listed as parts by weight, make primarily of squaw weed 30 parts, Leaf of Chinese Holly 30 parts and auxiliary material.
A preparation method for the medicine of aforementioned therapies burn, gets squaw weed and Leaf of Chinese Holly, after soaking with boiling water, decocts and boils, and decocting liquid filters, and filtrate is condensed into medicinal extract, adds auxiliary material or does not add auxiliary material, and preparation method conveniently processes, and makes pharmaceutical preparation.
In the preparation method of the medicine of aforementioned therapies burn, described pharmaceutical preparation is external preparation or oral preparations.
In the preparation method of the medicine of aforementioned therapies burn, described external preparation is ointment or patch; Described oral preparations is decoction, capsule, tablet or granule.
Aforementioned therapies burn medicine preparation method in, described ointment is prepared like this: gets squaw weed and Leaf of Chinese Holly, soaks 20-28h with boiling water, decoct boil 15-25min, decocting liquid filter, filtrate concentrate to relative density when 80-90 DEG C be the medicinal extract of 1.05～1.15; Get the sorbyl alcohol of medicinal extract amount 1-2 times and the glycerine of 1.5-2.3 times, add in above-mentioned medicinal extract, be heated to 80-85 DEG C and make dissolving;Separately get medicinal extract amount 1.5-2.3 stearic acid doubly, 1-2 stearic acid doubly, 0.4-0.8 Yellow Vaselin doubly, 1.5-2.3 poly-sorb fat 80 doubly, 0.2-0.6 lanolin doubly and 0.1-0.3 sucrose stearate doubly is heated to 80-85 DEG C, make melting, by above-mentioned two kinds of solution mixing and emulsifyings 10-20 minute, 80-85 DEG C is incubated 25-35 minute, the phenylformic acid and the 0.30-0.34 ethylparoben doubly that add the amount of making 0.02-0.06 times mix even, filling, to obtain final product.
Aforementioned therapies burn medicine preparation method in, described patch is prepared like this: gets squaw weed and Leaf of Chinese Holly, soaks 20-28h with boiling water, decoct boil 15-25min, decocting liquid filter, filtrate concentrate to relative density when 80-90 DEG C be the medicinal extract of 1.05～1.15; Separately get the rubber of medicinal extract weight 50%, the rosin of 50%, the Vaseline of 10% and 20% lanolin heating and melting, then add above-mentioned medicinal extract, and the glycerine of medicinal extract weight 15% and 60% zinc oxide mix and blend 15-30 minute, obtain medicine material, to mount respectively in material, medical mylar and medicine material loading patch spreading equipment, roll, after shaping, cutting, packing, sealing, packaging, to obtain final product.
In the preparation method of the medicine of aforementioned therapies burn, described decoction is prepared like this: gets squaw weed and Leaf of Chinese Holly, soaks 20-28h with boiling water, decocts and boils 15-25min, and decocting liquid is condensed into concentrated solution, to obtain final product.
In the preparation method of the medicine of aforementioned therapies burn, described capsule is prepared like this: get squaw weed and Leaf of Chinese Holly, soaking 20-28h with boiling water, decoct and boil 15-25min, decocting liquid filters, filtrate concentrate to relative density when 80-90 DEG C be the medicinal extract of 1.05～1.15, medicinal extract mixes even with starch and the Magnesium Stearate of the amount of making 10-20%, dry, granulates, load capsule, to obtain final product.
The present invention makes primarily of squaw weed and Leaf of Chinese Holly, wherein squaw weed (SenecioscandensBuch.-Ham.exD.Don). Being a kind of herbal medicine, it is cold in nature, bitter, and function cures mainly: clearing heat and detoxicating; Improving acuity of vision and removing nebula; Killing parasites to relieve itching. Main flow sense; Upper respiratory tract infection; Pneumonia; Acute tonsillitis; Rib adenositis; Acute enteritis; Bacillary dysentery; Icterohepatitis; The wet tinea of courage is scorching; Acute urinary tract infection; Conjunctival congestion with pain and swelling of the eye ocular; The swollen furuncle poison of carbuncle; Erysipelas; Eczema; Dry wet tinea sore; Trichomonal vaginitis; Burn and scald. Leaf of Chinese Holly, English name LeafofChineseHolly, leafofBroadleafHolly, it it is Chinese ilex section Ilex latifolia Thunb kind aiphyllium, the medicinal effect of Leaf of Chinese Holly is obvious, the traditional Chinese medical science is thought, it has the effect of loose wind-heat, the clear head, relieving thirst and restlessness, can be used to treatment headache, toothache, hot eyes, pyreticosis polydipsia, dysentery etc. Modern pharmacological research then proves, not only containing trace elements such as the multiple amino acids of needed by human, VITAMIN and zinc, manganese, rubidiums in Leaf of Chinese Holly, also there is reducing blood-fat, increase coronary artery blood flow, increase the effect such as blood supply of cardiac muscle, atherosclerosis, the symptoms such as the dizziness of cardiovascular and cerebrovascular diseases patient, headache, uncomfortable in chest, weak, insomnia are all had good preventive and therapeutic effect. Said medicine prescription, plays pain relieving altogether, effect of myogenic, and burn or scald are had obvious result for the treatment of.
Invention has been a large amount of experiment research, below for the present invention tests the result of research:
Experimental example 1: pharmacodynamic study
1 data and method
1.1 physical data in December ,-2015 in June, 2014, Guizhou Province People ' s Hospital accepts 180 example fire victims for medical treatment, all meets light degree Ⅱ and deep?degreeburn standard. Man 67 example, female 53 example;Year at age 2-68. Wherein hot water scalds 40 examples, flame burn 30 example, chemical burn 50 example. Four limbs burn 65 example; Head facial burn 22 example; Trunk, burn of perineal region 33 example. 180 example patients are divided into observation group 1, observation group 2 and control group at random, each group 60 example, wherein man 32 example in observation group 1, female 28 example; Light degree Ⅱ 29 example, dark II degree of 31 example; Burn area 2.3%-29.9%. Man 33 example in observation group 2, female 27 example; Light degree Ⅱ 29 example, dark II degree of 31 example; Burn area 2.3%-29.9%. Man 34 example in control group, female 26 example, light degree Ⅱ 24 example, dark II degree of 36 example; Burn area 2.4%-30.2%. 3 groups of physical data have comparability.
1.2 method
Can puncture from lowest order with aseptic syringe needle for the bubble surface of a wound, drainage transudate. Downright bad Beancurd sheet that is free or fold is removed, removes after totally and sterilize again 1 time, for vesicle, it is possible to need not process, avoid destroying bubble surface skin tissue, reduce the chance infected. For burn area below 5% and less than the II degree of patient infected, give oral antibiotic or intramuscular injection. For burning area relatively greatly, and the patient reaching dark II degree gives microbiotic, intravenous infusion, replenishment of blood content, maintains water, the balance of ionogen, prevents shock and other complication. The surface of a wound being had to the patient infecting or having fester, available hydrogen peroxide carries out sterilizing and cleaning, then processes with 0.1% Morpan BB. Thereafter observation group 1 gives ointment of the present invention (being prepared by embodiment 1) at burned part, observation group 2 gives moist expose burn ointment at burned part, two groups of every days all give 3 times, the surface of a wound is kept to clean, before changing dressings, the exudate of patient's burn wound is cleaned clean every time, then coat ointment of the present invention; When transudate is too much, it is possible to adopt the clear liquid of benzalkonium bromide solution of 0.1%; When removing necrotic tissue and exudate, the destruction to active mass should be avoided, act on and do not damage living tissue principle as far as possible. Control group wound site is disinfected equally by observation group 1 and observation group 2 surface of a wound sterilization method, and burn wound gives physiological saline, and every day changes dressings 5-6 time.
1.3 curative effect judging standard
Cure: burn wound healing also has and infects and leave scar, and without serious pigmentation; Effective: II degree of surface of a wound part area healing, part traumatic infection, need to make skin graft and just recover; Invalid: cannot to heal, it is invalid to regard as with additive method treatment.
1.4 statistical method
Adopt t inspection and x2Inspection.
2 results
2.13 groups of comparitive study the results are shown in Table 1.
Table 1
Note: compare with control group,*P < 0.05;**P < 0.01;
Compare with observation group 2,#p<0.05。
As seen from table, ointment of the present invention can significantly improve treatment burn always have efficiency, result for the treatment of is good, is better than observation group 2.
2.23 groups of healing time comparative results are in table 2.
Table 2 is respectively organized healing time and is compared
Note: compare with control group,*P < 0.01;
Compare with observation group 2,#p<0.05。
As seen from table, observation group 1 and observation group 2 light degree Ⅱ and dark II degree of surface of a wound healing time are all significantly shorter than control group, and the healing time of observation group 1 is shorter than observation group 2. Ointment of the present invention obviously shortens wound healing time, and effect is better.
Experimental example 2: rabbit skin irritation test
1. experimental apparatus: Shearing shears, sand paper, gauze, adhesive tape etc.
2. test the tested medicine of medicine: ointment of the present invention (is prepared according to the method for embodiment 1).Positive control medicine: compound nystatin ointment (Oridermyl), lot number 200704121, the grand pharmacy of method national strength and prestige.
3. laboratory animal adult healthy white rabbit 8 (about 2kg), male and female half and half, are provided by medical college of Yangzhou University.
4. experimental technique:
(1) rabbit Skin sensitization test: before administration, hair is removed in both sides, back by 24h, scope accounts for 10% (about 150cm of whole body surface area2), after removing hair, 24h checks skin of unhairing. Rabbit skin is divided into two kinds of situations, and one is skin zero damage, and such rabbit is cooked integrity tuerculoderma group; One has damage for skin, and hair sterilization skin sand paper will be gone to rub, and taking micro-blood that oozes as degree, both sides damaged degree is basically identical, and this type of rabbit is cooked destructive tuerculoderma group.
(2) experimental technique: adopting side, left and right self-contrast, side is control group, and another side is reagent group. Tested material 1g is applied to tested district, left side, and right side is coated with the compound nystatin ointment of equivalent or drips physiological saline in contrast, and adopts non-stimulated gauze, adhesive plaster etc. fixing, and every single cage of animal is raised. After test medicine 24h, clean with warm water or brine and smear position, remove residual tested material, respectively observed and recorded remove tested material after 1,24,48,72h smears position and reacts with or without redness, oedema etc. Smear position to mark by table 2, record each score value.
5. skin irritation reaction scoring and stimulus intensity judgement criteria, in table 3 and 4.
Table 3
Table 4
6. result
What skin irritation was tested the results are shown in Table 5.
Table 5
Result shows, and ointment of the present invention is to the equal nonirritant of intact skin and injured skin.
Compared with prior art, described medicine has clearing heat and detoxicating, pain relieving, effect of myogenic, can effectively treat burn, scald etc. And good effect, healing time is short. Reach goal of the invention.
The present invention is described by the following examples further, but not as limitation of the present invention.
Embodiment:
Embodiment 1:
Prescription: squaw weed 30g and Leaf of Chinese Holly 30g.
Matrix: sorbyl alcohol 70g, glycerine 80g, stearic acid 80g, stearic 70g, Yellow Vaselin 30g, sucrose stearate 10g, lanolin 20g, Polysorbate 80 80g, phenylformic acid 6g ethylparoben 1.5g.
Technique: get squaw weed and Leaf of Chinese Holly, soak 24h with boiling water, decoct boil 20min, decocting liquid filter, filtrate concentrate to relative density when 80-90 DEG C be the medicinal extract of 1.05～1.15; Get sorbyl alcohol and glycerine, add in above-mentioned medicinal extract, be heated to 80-85 DEG C and make dissolving; Separately get stearic acid, tristearin, Yellow Vaselin, poly-sorb fat 80, lanolin and sucrose stearate and it is heated to 80-85 DEG C, make melting, by above-mentioned two kinds of solution mixing and emulsifyings 15 minutes, 80-85 DEG C is incubated 30 minutes, add phenylformic acid and ethylparoben mixes even, filling, obtain ointment.
Usage and dosage: external application is applied to affected part, every day 2-3 time, severe person every day 3-4 time.
Embodiment 2:
Prescription: squaw weed 30g and Leaf of Chinese Holly 30g.
Technique: get squaw weed and Leaf of Chinese Holly, soak 24h with boiling water, decocts and boils 20min, and decocting liquid is condensed into concentrated solution, obtains decoction.
Usage and dosage: oral, every day 2-3 time, each 100-150ml.
Embodiment 3:
Prescription: squaw weed 40g and Leaf of Chinese Holly 40 parts.
Technique: get squaw weed and Leaf of Chinese Holly, soak 24h with boiling water, decoct boil 20min, decocting liquid filter, filtrate concentrate to relative density when 80-90 DEG C be the medicinal extract of 1.05～1.15; Separately get the rubber of medicinal extract weight 50%, the rosin of 50%, the Vaseline of 10% and 20% lanolin heating and melting, then add above-mentioned medicinal extract, and the glycerine of medicinal extract weight 15% and 60% zinc oxide mix and blend 15-30 minute, obtain medicine material, to mount respectively in material, medical mylar and medicine material loading patch spreading equipment, roll, after shaping, cutting, packing, sealing, packaging, obtains patch.
Usage and dosage: be affixed on affected part, every day, 1-2 pasted.
Claims (10)
1. treat the medicine of burn for one kind, it is characterised in that: according to listed as parts by weight, make primarily of squaw weed 10-50 part, Leaf of Chinese Holly 10-50 part and auxiliary material.
2. treat the medicine of burn as claimed in claim 1, it is characterised in that: according to listed as parts by weight, make primarily of squaw weed 20-40 part, Leaf of Chinese Holly 20-40 part and auxiliary material.
3. treat the medicine of burn as claimed in claim 2, it is characterised in that: according to listed as parts by weight, make primarily of squaw weed 30 parts, Leaf of Chinese Holly 30 parts and auxiliary material.
4. as according to any one of claim 1-3, treat the preparation method of the medicine of burn for one kind, it is characterized in that: get squaw weed and Leaf of Chinese Holly, after soaking with boiling water, decoct and boil, decocting liquid filters, and filtrate is condensed into medicinal extract, adds auxiliary material or does not add auxiliary material, preparation method conveniently processes, and makes pharmaceutical preparation.
5. treat the preparation method of the medicine of burn as claimed in claim 4, it is characterised in that: described pharmaceutical preparation is external preparation or oral preparations.
6. treat the preparation method of the medicine of burn as claimed in claim 5, it is characterised in that: described external preparation is ointment or patch; Described oral preparations is decoction, capsule, tablet or granule.
7. the preparation method of the medicine for the treatment of burn as claimed in claim 6, it is characterized in that: described ointment is prepared like this: get squaw weed and Leaf of Chinese Holly, soak 20-28h with boiling water, decoct and boil 15-25min, decocting liquid filter, filtrate concentrate to relative density when 50-60 DEG C be the medicinal extract of 1.05～1.15; Get the sorbyl alcohol of medicinal extract amount 1-2 times and the glycerine of 1.5-2.3 times, add in above-mentioned medicinal extract, be heated to 80-85 DEG C and make dissolving; Separately get medicinal extract amount 1.5-2.3 stearic acid doubly, 1-2 stearic acid doubly, 0.4-0.8 Yellow Vaselin doubly, 1.5-2.3 poly-sorb fat 80 doubly, 0.2-0.6 lanolin doubly and 0.1-0.3 sucrose stearate doubly is heated to 80-85 DEG C, make melting, by above-mentioned two kinds of solution mixing and emulsifyings 10-20 minute, 80-85 DEG C is incubated 25-35 minute, the phenylformic acid and the 0.30-0.34 ethylparoben doubly that add the amount of making 0.02-0.06 times mix even, filling, to obtain final product.
8. the preparation method of the medicine for the treatment of burn as claimed in claim 6, it is characterized in that: described patch is prepared like this: get squaw weed and Leaf of Chinese Holly, soak 20-28h with boiling water, decoct and boil 15-25min, decocting liquid filter, filtrate concentrate to relative density when 50-60 DEG C be the medicinal extract of 1.05～1.15; Separately get the rubber of medicinal extract weight 50%, the rosin of 50%, the Vaseline of 10% and 20% lanolin heating and melting, then add above-mentioned medicinal extract, and the glycerine of medicinal extract weight 15% and 60% zinc oxide mix and blend 15-30 minute, obtain medicine material, to mount respectively in material, medical mylar and medicine material loading patch spreading equipment, roll, after shaping, cutting, packing, sealing, packaging, to obtain final product.
9. the preparation method of the medicine for the treatment of burn as claimed in claim 6, it is characterised in that: described decoction is prepared like this: gets squaw weed and Leaf of Chinese Holly, soaks 20-28h with boiling water, decocts and boils 15-25min, and decocting liquid is condensed into concentrated solution, to obtain final product.
10. the preparation method of the medicine for the treatment of burn as claimed in claim 6, it is characterized in that: described capsule is prepared like this: get squaw weed and Leaf of Chinese Holly, soaking 20-28h with boiling water, decoct and boil 15-25min, decocting liquid filters, filtrate concentrate to relative density when 50-60 DEG C be the medicinal extract of 1.05～1.15, medicinal extract mixes even with starch and the Magnesium Stearate of the amount of making 10-20%, dry, granulates, load capsule, to obtain final product.
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| CN201610149735.XA CN105663198A (en) | 2016-03-16 | 2016-03-16 | Medicine for treating burn and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547188A (en) * | 2014-12-31 | 2015-04-29 | 贵州苗康医药科技有限公司 | External preparation for treating varicosity and preparation method thereof |
| CN104906541A (en) * | 2015-06-12 | 2015-09-16 | 马志刚 | Ointment for burn nursing |
-
2016
- 2016-03-16 CN CN201610149735.XA patent/CN105663198A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547188A (en) * | 2014-12-31 | 2015-04-29 | 贵州苗康医药科技有限公司 | External preparation for treating varicosity and preparation method thereof |
| CN104906541A (en) * | 2015-06-12 | 2015-09-16 | 马志刚 | Ointment for burn nursing |
Non-Patent Citations (2)
| Title |
|---|
| 唐桂文: "千里光治疗水火烫伤", 《新中医》 * |
| 汉华编著: "《常见食物药用》", 31 October 2001, 海洋出版社 * |
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Application publication date: 20160615 |