CN105660622B - A kind of citric acid iodine foam-type disinfectant and preparation method thereof - Google Patents
A kind of citric acid iodine foam-type disinfectant and preparation method thereof Download PDFInfo
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- CN105660622B CN105660622B CN201610121942.4A CN201610121942A CN105660622B CN 105660622 B CN105660622 B CN 105660622B CN 201610121942 A CN201610121942 A CN 201610121942A CN 105660622 B CN105660622 B CN 105660622B
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- foam
- citric acid
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- type disinfectant
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/16—Foams
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
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Abstract
The present invention proposes a kind of citric acid iodine foam-type disinfectant and preparation method thereof, composed of the following components：5~50wt% of citric acid, 0.5~5wt% of iodine, 0~20wt% of KI, 0~10wt% of 0~20wt% of Potassiumiodate, 0.1~10wt% of foaming agent and foam stabilizer, surplus is solvent；The solvent is made up of water and organic solvent.Preparation method comprises the following steps：1) citric acid is dissolved in the water of part and obtains solution I, iodine, KI and Potassiumiodate are dissolved in remaining water and obtain solution II；2) solution I in step 1) and solution II are mixed to get solution III；3) foaming agent and foam stabilizer are added in the solution III that step 2) obtains, and add organic solvent.The disinfectant half foam life period is grown, and Disinfection Effect is good.
Description
Technical field
The invention belongs to disinfectant technical field, and in particular to a kind of citric acid iodine foam-type disinfectant and its preparation side
Method.
Background technology
Foam-type disinfectant is a kind of emerging disinfectant formulation, is ground at present on foam-type disinfectant product and correlation
It is less to study carefully report.Compared to traditional solid, liquid disinfectant, foam-type disinfectant has advantages below：1. adhesive force is strong, sterilization
The more thorough characteristic of effect；2. foam-type disinfectant is time saving and energy saving, dosage is few, and noresidue is cost-effective, more environmentally friendly；3. new
During the outburst preventing and treating of type epidemic disease, foam-type disinfectant purposes is more effective extensively.
Citric acid iodine solution is a kind of rufous liquid disinfectant, is developed by Zhengdian Biological Tech. Co., Ltd., Foshan City
Novel chiral synthon, the granted class novel chiral synthon of the People's Republic of China (PRC) three in 2014, the sterilization for mew, air.According to research reports, Chinese holly
Rafter acid iodine solution is a kind of wide spectrum, efficient, noresidue, low stimulation, environment-friendlydisinfectant disinfectant, is another breakthrough in disinfectant field
Innovation.However, the report that citric acid iodine is prepared to foam-type disinfectant is had no at present.
The content of the invention
To solve the above-mentioned problems of the prior art, the present invention proposes a kind of citric acid iodine foam-type disinfectant, and this disappears
Toxic agent half foam life period is grown, and Disinfection Effect is good.
The technical proposal of the invention is realized in this way：
A kind of citric acid iodine foam-type disinfectant, it is composed of the following components：
5~50wt% of citric acid, 0.5~5wt% of iodine, 0~20wt% of KI, 0~20wt% of Potassiumiodate, foaming agent
0.1~10wt% and 0~10wt% of foam stabilizer, surplus is solvent；The solvent is made up of water and organic solvent.
Further, the content of the Potassiumiodate is 1~20wt%.
Further, the organic solvent is a kind of or more in ethanol, propane diols, glycerine and polyethylene glycol 400
Kind.
Further, the foaming agent is selected from stearic acid, dodecyl sodium sulfate, neopelex, dodecyl
Dimethyl benzyl ammonium chloride, glycerin monostearate, quaternary ammonium compound, lecithin, fatty glyceride, cellulose acetate, sapn,
One or more in tween, dioctyl succinate disulfonate acid and sodium glycocholate, preferably dodecyl sodium sulfate, dodecane
Base benzene sulfonic acid sodium salt or dodecyl benzyl dimethyl ammonium chloride.
Further, the foam stabilizer is selected from CMS, acetic starch, hydroxymethyl cellulose, hydroxypropyl cellulose, carboxylic
Methylcellulose, soluble starch, polyacrylamide, hydrolyzed polyacrylamide, polyvinylpyrrolidone, Arabic gum, xanthan
One or more in glue, sodium alginate and soluble resin, preferably polyvinylpyrrolidone, Arabic gum or xanthans.
It is a further object to provide a kind of preparation method of citric acid iodine foam-type disinfectant, including following step
Suddenly：
1) citric acid is dissolved in the water of part and obtains solution I, iodine, KI and Potassiumiodate are dissolved in remaining water and obtained
To solution II；
2) solution I in step 1) and solution II are mixed to get solution III；
3) foaming agent and foam stabilizer are added in the solution III that step 2) obtains, and add organic solvent.
Further, in addition to by step 3) the direct stoste of disinfectant that obtains injects foam device after dilution, is sending out
Use after 3~10wt% of addition propellant is packaged in bulb apparatus.
Further, the propellant is propane or butane.
Further, the organic solvent is a kind of or more in ethanol, propane diols, glycerine and polyethylene glycol 400
Kind.
Further, the foaming agent is selected from stearic acid, dodecyl sodium sulfate, neopelex, dodecyl
Dimethyl benzyl ammonium chloride, glycerin monostearate, quaternary ammonium compound, lecithin, fatty glyceride, cellulose acetate, sapn,
One or more in tween, dioctyl succinate disulfonate acid and sodium glycocholate；The foam stabilizer is selected from CMS, vinegar
Acid-starch, hydroxymethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, soluble starch, polyacrylamide, hydrolysis poly- third
One or more in acrylamide, polyvinylpyrrolidone, Arabic gum, xanthans, sodium alginate and soluble resin.
Beneficial effects of the present invention：
Citric acid iodine foam-type disinfectant of the present invention effectively combines citric acid and iodine, and the disinfectant has compared with other biographies
The formulation disinfectants such as system solid, liquid have advantages below：1. adhesive force is strong, disinfecting time continues more long, and Disinfection Effect is more thorough
The characteristic at bottom；2. foam-type disinfectant is time saving and energy saving, dosage is few, and noresidue is cost-effective, more environmentally friendly.3. disinfectant foam half
Decline phase length, good sterilization effect.
Embodiment
Embodiment 1
A kind of citric acid iodine foam-type disinfectant, it is composed of the following components：
Citric acid 10wt%, iodine 2wt%, KI 1.5wt%, neopelex 1wt% and carboxymethyl cellulose
Plain sodium 0.25wt%, water 15wt% and ethanol 70.25wt%.
A kind of preparation method of citric acid iodine foam-type disinfectant, comprises the following steps：
1) citric acid is dissolved in 10wt% water and obtains solution I, iodine is dissolved in 5wt% water with KI obtain it is molten
Liquid II；
2) solution I in step 1) and solution II are mixed to get solution III；
3) foaming agent and foam stabilizer are added in the solution III that step 2) obtains, and add ethanol.
Embodiment 2
A kind of citric acid iodine foam-type disinfectant, it is composed of the following components：
Citric acid 50wt%, iodine 0.5wt%, KI 1wt%, Potassiumiodate 1wt%, cellulose acetate 0.1wt% are with gathering
Vinylpyrrolidone 10wt%, water 10wt% and glycerine 27.4wt%.
A kind of preparation method of citric acid iodine foam-type disinfectant, comprises the following steps：
1) citric acid is dissolved in 5wt% water and obtains solution I, iodine, KI and Potassiumiodate are dissolved in 5wt% water
Obtain solution II；
2) solution I in step 1) and solution II are mixed to get solution III；
3) foaming agent and foam stabilizer are added in the solution III that step 2) obtains, and add glycerine；
4) the direct stoste injection foam device of disinfectant obtained step 3), 10wt% fourth is added in foam device
Use after alkane is packaged.
Embodiment 3
A kind of citric acid iodine foam-type disinfectant, it is composed of the following components：
Citric acid 5wt%, iodine 5wt%, KI 20wt%, Potassiumiodate 20wt%, quaternary ammonium compound 10wt% and alginic acid
Sodium 1wt%, water 19wt% and propane diols 20wt%.
A kind of preparation method of citric acid iodine foam-type disinfectant, comprises the following steps：
1) citric acid is dissolved in 10wt% water and obtains solution I, iodine, KI and Potassiumiodate are dissolved in 9wt% water
In obtain solution II；
2) solution I in step 1) and solution II are mixed to get solution III；
3) foaming agent and foam stabilizer are added in the solution III that step 2) obtains, and add propane diols；
4) the direct stoste injection foam device of disinfectant obtained step 3), adds the third of 3wt% in foam device
Use after alkane is packaged.
Embodiment 4
Citric acid iodine foam-type disinfectant half foam life period determines
Using improvement warring blender methods, i.e., by 50ml embodiments 1-3 foam disinfectant agent solution with 3000~
5000r/min quickly stirs 1min, observes foam volume and half foam life period (the time required to i.e. foam separates out liquid 25ml), knot
Fruit is shown in Table 1：
The citric acid iodine foam-type disinfectant half foam life period measurement result of table 1
Embodiment 5
Citric acid iodine foam-type disinfectant the result for spot disinfection is evaluated
1 test material：
1.1 trial drug：The foam-type disinfectant of embodiment 1~3, citric acid iodine solution (are selected from the positive allusion quotation biology skill in Foshan City
Art Co., Ltd)；
1.2 nertralizer：Bactericidal nurishing meat soup containing 0.3% sodium thiosulfate, 1% Tween-80；
1.3 sample solution:Sample solution is used as using nertralizer.
1.4 culture medium：Martin's agar plate containing 10% calf serum.
2nd, experiment packet：
Test group：The embodiment of the present invention 1~3,1:300 dilutions；
Test control group：Citric acid iodine solution group, 1:300 dilutions；
Blank control group：Disinfectant is replaced to synchronize experiment with running water.
3rd, test method：
3.1 sterilization method：Choose 5 area about 20m2Pig house be randomly divided into 5 groups, rushed before sterilization with running water
Wash, the formal test stage is entered after natural drying.Test group loads disinfectant spray disinfectant, test control group using foam device
Sterilized using atomizers spray, moistened using ground but do not produce current as standard, ensure every square metre of 200~300ml of sprinkling.Point
10min, 30min, 60min sample to the ground of colony house, metope, crib not before sterilization and after sterilization, each point sampling 3
It is secondary, and count plate is carried out to sample.
3.2 the method for sampling：After sterile cotton swab is infiltrated with nertralizer, area is chosen in the ground of colony house, metope, crib
5×5cm2Respectively firmly wiped 10 times anyhow in region, and constantly change wiping surface, sterile cotton swab is cut in 5ml centrifuge tubes,
Title.
3.3 viable count method：After sample is taken back into laboratory, sterile saline 2ml is separately added into, is vortexed
1min, fully elution, then with physiological saline gradient dilution to suitable concentration as far as possible, in Martin's agar containing 10% calf serum
Count plate culture is done in plate.
4th, result of the test：
Concrete outcome see the table below 2~4.
The citric acid iodine foam-type disinfectant ground sterilization effect assessment of table 2
Note：Embodiment and citric acid iodine solution difference sterilizing rate (%)=(sterilizing rate average value of embodiment 1~3-citric acid
Iodine solution sterilizing rate)/citric acid iodine solution sterilizing rate × 100.
The citric acid iodine foam-type disinfectant metope Evaluation of Disinfection of table 3
Note：Embodiment and citric acid iodine solution difference sterilizing rate (%)=(sterilizing rate average value of embodiment 1~3-citric acid
Iodine solution sterilizing rate)/citric acid iodine solution sterilizing rate × 100.
The citric acid iodine foam-type disinfectant crib Evaluation of Disinfection of table 4
Note：Embodiment and citric acid iodine solution difference sterilizing rate (%)=(sterilizing rate average value of embodiment 1~3-citric acid
Iodine solution sterilizing rate)/citric acid iodine solution sterilizing rate × 100.
As seen from the above table, after sterilization in 60min, the embodiment of the present invention 1~3 and citric acid iodine solution Disinfection Effect compare
Good, sterilizing rate is up to more than 99%.But in general, it is molten to be superior to citric acid iodine for the Disinfection Effect of the embodiment of the present invention 1~3
Liquid, and with the passage of time after sterilization, the embodiment of the present invention 1~3 and citric acid iodine solution difference sterilizing rate are increasing,
Illustrate to elapse over time, the bactericidal effect of the embodiment of the present invention 1~3 is better than citric acid iodine solution.Therefore, the present invention is implemented
The Disinfection Effect of example 1~3 is good, more thorough compared to general formulation disinfectant Disinfection Effect.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
God any modification, equivalent substitution and improvements made etc., should be included in the scope of the protection with principle.
Claims (7)
1. a kind of citric acid iodine foam-type disinfectant, it is characterised in that composed of the following components：
5~50wt% of citric acid, 0.5~5wt% of iodine, 0~20wt% of KI, 1~20wt% of Potassiumiodate, foaming agent 0.1~
10wt% and 0~10wt% of foam stabilizer, surplus is solvent；The solvent is made up of water and organic solvent, the organic solvent choosing
From propane diols or glycerine.
2. citric acid iodine foam-type disinfectant according to claim 1, it is characterised in that the foaming agent is selected from tristearin
Acid, dodecyl sodium sulfate, neopelex, dodecyl benzyl dimethyl ammonium chloride, glycerin monostearate, season
Ammonium compound, lecithin, fatty glyceride, cellulose acetate, sapn, tween, dioctyl succinate disulfonate acid and sodium glycocholate
In one or more.
3. citric acid iodine foam-type disinfectant according to claim 1, it is characterised in that the foam stabilizer is selected from carboxymethyl
Starch, acetic starch, hydroxymethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, soluble starch, polyacrylamide, water
Solve polyacrylamide, polyvinylpyrrolidone, Arabic gum, xanthans, sodium alginate and one kind or more in soluble resin
Kind.
4. a kind of preparation method of citric acid iodine foam-type disinfectant as claimed in claim 1, it is characterised in that including following
Step：
1) citric acid is dissolved in the water of part and obtains solution I, iodine, KI and Potassiumiodate are dissolved in remaining water obtain it is molten
Liquid II；
2) solution I in step 1) and solution II are mixed to get solution III；
3) foaming agent and foam stabilizer are added in the solution III that step 2) obtains, and add organic solvent.
5. the preparation method of citric acid iodine foam-type disinfectant according to claim 4, it is characterised in that also including will step
The rapid direct stoste of disinfectant 3) obtained injects foam device after dilution, and pushing away for 3~10wt% is added in foam device
Enter use after agent is packaged.
6. the preparation method of citric acid iodine foam-type disinfectant according to claim 5, it is characterised in that the propellant
For propane or butane.
7. the preparation method of citric acid iodine foam-type disinfectant according to claim 4, it is characterised in that the foaming agent
Selected from stearic acid, dodecyl sodium sulfate, neopelex, dodecyl benzyl dimethyl ammonium chloride, monostearate
Glyceride, quaternary ammonium compound, lecithin, fatty glyceride, cellulose acetate, sapn, tween, dioctyl succinate disulfonate acid with
One or more in sodium glycocholate；The foam stabilizer is selected from CMS, acetic starch, hydroxymethyl cellulose, hydroxypropyl
Base cellulose, carboxymethyl cellulose, soluble starch, polyacrylamide, hydrolyzed polyacrylamide, polyvinylpyrrolidone, Ah
Draw the one or more in primary glue, xanthans, sodium alginate and soluble resin.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610121942.4A CN105660622B (en) | 2016-03-03 | 2016-03-03 | A kind of citric acid iodine foam-type disinfectant and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610121942.4A CN105660622B (en) | 2016-03-03 | 2016-03-03 | A kind of citric acid iodine foam-type disinfectant and preparation method thereof |
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| Publication Number | Publication Date |
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| CN105660622A CN105660622A (en) | 2016-06-15 |
| CN105660622B true CN105660622B (en) | 2018-01-09 |
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| CN106376560B (en) * | 2016-08-19 | 2019-09-06 | 四川恒通动保生物科技有限公司 | A kind of charged foam type Iodic acid disinfectant and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1238131A (en) * | 1998-06-09 | 1999-12-15 | 孙文国 | Efficient disinfectant tamed iodine |
| CN1528341A (en) * | 2003-09-30 | 2004-09-15 | 重庆海兰生物工程有限公司 | Povidone-iodine foamable composition |
| CN101081024A (en) * | 2007-06-29 | 2007-12-05 | 中山市凯达精细化工股份有限公司 | Aqueous-base foam type spray for killing ant and method for making the same |
| CN101507430A (en) * | 2009-03-31 | 2009-08-19 | 中国检验检疫科学研究院 | Freezeproof foam disinfectant and preparation method thereof |
-
2016
- 2016-03-03 CN CN201610121942.4A patent/CN105660622B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1238131A (en) * | 1998-06-09 | 1999-12-15 | 孙文国 | Efficient disinfectant tamed iodine |
| CN1528341A (en) * | 2003-09-30 | 2004-09-15 | 重庆海兰生物工程有限公司 | Povidone-iodine foamable composition |
| CN101081024A (en) * | 2007-06-29 | 2007-12-05 | 中山市凯达精细化工股份有限公司 | Aqueous-base foam type spray for killing ant and method for making the same |
| CN101507430A (en) * | 2009-03-31 | 2009-08-19 | 中国检验检疫科学研究院 | Freezeproof foam disinfectant and preparation method thereof |
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