CN105641593A - 一种用于治疗冠心病的中药制剂及其制备方法 - Google Patents
一种用于治疗冠心病的中药制剂及其制备方法 Download PDFInfo
- Publication number
- CN105641593A CN105641593A CN201610023875.2A CN201610023875A CN105641593A CN 105641593 A CN105641593 A CN 105641593A CN 201610023875 A CN201610023875 A CN 201610023875A CN 105641593 A CN105641593 A CN 105641593A
- Authority
- CN
- China
- Prior art keywords
- radix
- rhizoma
- preparation
- fructus
- heart disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/424—Gynostemma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及中医药领域,尤其涉及一种用于治疗冠心病的中药制剂。由山茱萸、党参、山楂、金银花、生地、高良姜、五味子、益母草、野菊花、甘草、柴胡、黄芪、决明子、桃枝、白菜根、车前草、八角、西洋参、延胡索、桔梗、川穹、桃仁、檀香、三七、瓜蒌、牛黄、夜交藤、徐长卿、玉米须、厚朴、银杏叶等组成。本发明相对于现有技术具有疗效好、成本低、局限性小、无不良反应等优点。本发明中药制剂生产工艺简单,用药安全,稳定可靠,疗效好,是治疗冠心病的有效药物。与同类药物比较,本发明药物具有配伍严谨,药性平和,疗效显著的特点,便于在临床上大面积推广应用。
Description
技术领域
本发明属于中药学技术领域,具体涉及一种用于治疗冠心病的中药制剂及其制备方法。
背景技术
冠心病是冠状动脉粥样硬化性心脏病的简称,是指供给心脏营养物质的血管--冠状动脉发生严重粥样硬化或痉挛,使冠状动脉狭窄或堵塞,以及血栓形成造成的管腔闭塞,导致心肌缺血缺氧或梗塞的一种心脏病,亦称缺血性心脏病。冠心病是动脉粥样硬化导致器官病变的最常见类型,是危害中老年人健康的常见病,并呈现年轻化倾向。冠脉变窄的原因在于:血液中的血脂长期过高、胆固醇日积月累地沉淀在冠状动脉管腔的内膜上,形成地图样斑块,使本来光滑的内膜变的粗糙,柔软的管壁变得僵硬,在此基础上,破裂的血小板也凝聚粘附上去,于是就像河道被淤泥堵塞一样,使冠脉管腔变窄,甚至完全闭塞。冠脉的不畅甚至完全闭塞,造成心肌供血不好,心肌得不到血液的营养而坏死称为心肌梗死,这是冠心病最严重的表现。一旦心肌大面积梗死,又不能快速消除的话,那么人的生命也就结束了。
现代医学在这种理念的指导下,对心脏病的治疗手段大体分为两类:一是使用药物包括扩张血管类药物和溶栓溶脂类药物;二是支架、搭桥手术。在冠心病的治疗中,介入手术和搭桥手术都属于有创治疗,同时手术后并发症严重影响患者的身体健康。这些方法在对心脏病患者的治疗特别是在抢救性阶段有重要意义是行之有效的。但是却不能从源头上解决血管内脂质等垃圾的再次沉淀形成新的斑块,致使血管重新变窄、堵塞,心肌供血不畅老病复发的问题。
中医认为:“心主血,肺主力”,是说心与肺是胸腔中相邻的两个器官,心在前肺在后,心脏负责推进血液的运动,肺主呼吸。这就引起了医学界对呼吸与心脏关系的研究,心肺关系复杂交错,心脏消耗的氧气全部来源于肺,肺出问题直接导致心脏病。中医认为“心肺同源”这是心肺同治的理论源泉,心脏本身耗氧占整个人体的20%左右,若肺部出现病变,最先缺氧的就是心脏。如果长期轻度缺氧,会使心肌收缩增强,心率加快引发冠心病,严重缺氧时血压、心率均下降,导致心肌坏死,心力主衰竭,甚至心脏骤停。
发明内容
为了克服现有技术中的不足,本发明提供一种用于治疗冠心病的中药制剂,对冠心病具有显著疗效。
为了解决上述技术问题,本发明采用的技术方案如下:一种用于治疗冠心病的中药制剂,由以下重量份数的各组分组成:
山茱萸1-30份、党参1-30份、山楂1-30份、金银花1-30份、生地1-30份、高良姜1-30份、五味子1-30份、益母草1-30份、野菊花1-30份、甘草1-30份、柴胡1-30份、黄芪1-30份、决明子1-30份、桃枝1-30份、白菜根1-30份、车前草1-30份、八角1-30份、西洋参1-30份、延胡索1-30份、桔梗1-30份、川穹1-30份、桃仁1-30份、檀香1-30份、三七1-30份、瓜蒌1-30份、牛黄1-30份、夜交藤1-30份、徐长卿1-30份、玉米须1-30份、银杏叶1-30份、淫羊藿1-30份、葛根1-30份、羌活1-30份、红景天1-30份、麦冬1-30份、仙茅1-30份、川楝子1-30份、桂枝1-30份、厚朴1-30份、罗勒1-30份、夏枯草1-30份、绞股蓝1-30份、花椒1-30份、砂仁1-30份、柏子仁1-30份、石菖蒲1-30份、半夏1-30份。
所述治疗冠心病的中药制剂,其所述中药制剂中各种原料药的重量份数可以优选为:
山茱萸1-15份、党参1-15份、山楂1-15份、金银花1-15份、生地1-15份、高良姜1-15份、五味子1-15份、益母草1-15份、野菊花1-15份、甘草1-15份、柴胡1-15份、黄芪1-15份、决明子1-15份、桃枝1-15份、白菜根1-15份、车前草1-15份、八角1-15份、西洋参1-15份、延胡索1-15份、桔梗1-15份、川穹1-15份、桃仁1-15份、檀香1-15份、三七1-15份、瓜蒌1-15份、牛黄1-15份、夜交藤1-15份、徐长卿1-15份、玉米须1-15份、厚朴1-15份、银杏叶1-15份、淫羊藿1-15份、葛根1-15份、羌活1-15份、红景天1-15份、麦冬1-15份、仙茅1-15份、川楝子1-15份、桂枝1-15份、罗勒1-15份、夏枯草1-15份、绞股蓝1-15份、花椒1-15份、砂仁1-15份、柏子仁1-15份、石菖蒲1-15份、半夏1-15份。
所述治疗冠心病的中药制剂,其所述中药制剂中各种原料药的重量份数还可以优选为:
山茱萸1-10份、党参1-10份、山楂1-10份、金银花1-10份、生地1-10份、高良姜1-10份、五味子1-10份、益母草1-10份、野菊花1-10份、甘草1-10份、柴胡1-10份、黄芪1-10份、决明子1-10份、桃枝1-10份、白菜根1-10份、车前草1-10份、八角1-10份、西洋参1-10份、延胡索1-10份、桔梗1-10份、川穹1-10份、桃仁1-10份、檀香1-10份、三七1-10份、瓜蒌1-10份、牛黄1-10份、夜交藤1-10份、徐长卿1-10份、玉米须1-10份、厚朴1-10份、银杏叶1-10份、淫羊藿1-10份、葛根1-10份、羌活1-10份、红景天1-10份、麦冬1-10份、仙茅1-10份、川楝子1-10份、桂枝1-10份、罗勒1-10份、夏枯草1-10份、绞股蓝1-10份、花椒1-10份、砂仁1-10份、柏子仁1-10份、石菖蒲1-10份、半夏1-10份。
所述治疗冠心病的中药制剂,所述中药制剂的剂型为:片剂、糖衣片剂、薄膜衣片剂、肠溶衣片剂、硬胶囊剂、软胶囊剂、口服液、口含剂、颗粒剂、冲剂、蜜丸剂、散剂、丹剂、溶液剂、注射剂、栓剂、硬膏剂或糖浆剂。
为解决上述技术问题,本发明还提供治疗冠心病的中药制剂的制备方法,所述制剂剂型为口服液剂,其制备方法包括:
a、取原料放入乙醇中浸泡,热提取2次,成膏状,为组分1;
b、药渣水提取2次,浓缩过滤为膏状,为组分2;
c、将上述两种膏状浓缩成糊状,灭菌,加入糊精,然后真空冷冻密封。
所述步骤a中,取原料加入5-10倍量的乙醇中浸泡1-2小时,加热提取2次,每次0.5小时,去上清液,合并提取液,100-180目滤过,再经截流分子量为5000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.10的浸膏,加热浓缩至膏状,静置备用,成为组分1。
所述步骤b中,将乙醇提取过的药渣放入5倍量水中,加热回流提取2次,每次提取时间为0.5小时,100-120目滤过,再经截流分子量为5000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.10的浸膏,加热浓缩至膏状,静置备用,成为组分2。
所述步骤c中,将上述两种组分膏状浓缩成糊状,浓缩液用CO60灭菌,辐照剂量8k,加入糊精,然后真空罐装密封即得,使用时直接饮用。
为解决上述技术问题,本发明还提供治疗冠心病的中药制剂的制备方法,所述制剂剂型为胶囊剂,其制备方法包括:
a.将所述原料放入粉碎机粉碎后过筛;
b.将过筛后剩下的颗粒物放入乙醇中加热回流提取2次;
c.再取上述乙醇提取后的药渣,加水加热回流提取1次;
d.将上述两种提取液合并,减压回收乙醇并喷雾干燥,得药粉;混合过筛得到的细粉装入胶囊制为胶囊剂。
为解决上述技术问题,本发明还提供治疗冠心病的中药制剂的制备方法,所述内服药物的剂型为丸剂,其制备步骤包括:
a.将所述原料药混合,切碎,过120目筛,得细药粉备用;
b.将未过筛的粗粉浸泡乙醇中提取2次;
c.再取上述步骤提取后的药渣,加水加热回流提取1次;
d.将上述两种提取液合并,减压回收乙醇成浸膏,与a步骤得到细药粉合并加入蜂蜜搓成丸剂。
本发明相对于现有技术具有疗效好、成本低、局限性小、无不良反应等优点。本发明中药组合物生产工艺简单,用药安全,稳定可靠,疗效好,是治疗冠心病的有效药物。与同类药物比较,本发明药物具有配伍严谨,药性平和,疗效显著的特点,便于在临床上大面积推广应用。
具体实施方式
发挥中医优势,研发具有自主知识产权和国际竞争力的治疗冠心病的创新中药,可以显著提升我国中医药在重大疾病防治领域的研究水平和市场竞争能力。
山茱萸:性味:酸,微温。①《本经》:"味酸,平。"②《吴普本草》:"神农、黄帝、雷公、扁鹊:酸,无毒。岐伯:辛。"③《别录》:"微温,无毒。"④《药性论》:"味咸辛,大热。"归经:入肝、肾经。①《汤液本草》:"入足厥阴、少阴经。"②《药品化义》:"入肝、心、肾三经。"⑧《本草经解》:"入手太阴肺经、足厥阴肝经。"功能主治:补肝肾,涩精气,固虚脱。治腰膝酸痛,眩晕,耳鸣,阳痿,遗精,小便频数,肝虚寒热,虚汗不止,心摇脉散。补益肝肾,涩精固脱。用于眩晕耳鸣、腰膝酸痛、阳痿遗精、遗尿尿频、崩漏带下、大汗虚脱、内热消渴。温肝补肾,除一切风,止月经过多,治老人尿频。
党参:性味:甘,平。①《本经逢原》:"甘,平。"②《本草再新》:"甘,平,无毒。"归经:《得配本草》:"入手、足太阴经气分。"功能主治:补中,益气,生津。治脾胃虚弱,气血两亏,体倦无力,食少,口渴,久泻,脱肛。①《本经逢原》:"清肺。"②《本草从新》:"补中益气,和脾胃,除烦渴。"③《纲目拾遗》:"治肺虚,益肺气。"④《科学的民间药草》:"补血剂。适用于慢性贫血,萎黄病,白血病,腺病,佝偻病。"⑤《中药材手册》:"治虚劳内伤,肠胃中冷,滑泻久痢,气喘烦渴,发热自汗,妇女血崩、胎产诸病。"
山楂:性味:酸、甘、微温。归经:归脾、胃、肝经。功能主治:消食健胃,行气散瘀。用于肉食积滞,胃脘胀满,泻痢腹痛,瘀血经闭,产后瘀阻,心腹刺痛,疝气疼痛;高脂血症。焦山楂消食导滞作用增强。用于肉食积滞,泻痢不爽。
金银花:性味:甘,寒。①《滇南本草》:"性寒,味苦。"②《本草正》:"味甘,气平,其性微寒。"归经:入肺、胃经。①《雷公炮制药性解》:"入肺经。"②《得配本草》:"入足阳明、太阴经。"功能主治:清热,解毒。治温病发热,热毒血痢,痈疡,肿毒,瘰疬,痔漏。①《滇南本草》:"清热,解诸疮,痈疽发背,丹流瘰疬。"②《生草药性备要》;"能消痈疽疔毒,止痢疾,洗疳疮,去皮肤血热。"③《本草备要》:"养血止渴。治疥癣。"
生地:大寒。主治妇人崩中血不止,及产后血上薄心、闷绝,伤身、胎动、下血,胎不落,堕坠,宛折,瘀血,留血,衄血,吐血,皆捣饮之。《药性论》:君。能补虚损,温中下气,通血脉。治产后腹痛,主吐血不止。又云生地黄,味甘,平,无毒。解诸热,破血,通利月水闭绝。不利水道,捣薄心腹,能消瘀血。病人虚而多热,加而用之。
高良姜:性味。味辛,性热。归经:归脾、胃经。功效:温胃止呕,散寒止痛。主治:用于脘腹冷痛,胃寒呕吐,嗳气吞酸。
五味子:性味:酸、甘,温。归经:归肺,心、肾经。功能主治:收敛固涩,益气生津,补肾宁心。用于久嗽虚喘,梦遗滑精,遗尿尿频,久泻不止,自汗,盗汗,津伤口渴,短气脉虚,内热消渴,心悸失眠。
益母草:性味:辛苦,凉。①《本草拾遗》:"寒。"②《本草蒙筌》:"味辛甘,气微温,无毒。"③《纲目》:"味辛微苦,无毒。"④《本草正》:"味微苦、微辛。微寒,性滑。"归经:入心包、肝经。①《本草汇言》:"手、足厥阴经。"②《药品化义》:"入肝、脾、包络三经。"③《本草再新》:"入心、脾、肾三经。"功能主治:活血,祛瘀,调经,消水。治月经不调,胎漏难产,胞衣不下,产后血晕,瘀血腹痛,崩中漏下,尿血,泻血,痈肿疮疡。
野菊花:性味:苦辛,凉。①《本草汇言》:"味苦辛,气凉,有小毒。"②《四川中药志》:"性微寒,味甘苦,无毒。"归经:《本草求真》:"入肺、肝。"功能主治:疏风清热,消肿解毒。治风热感冒,肺炎、白喉,胃肠炎:高血压,疔,痈,口疮,丹毒,湿疹,天泡疮。①《本草汇言》:"破血疏肝,解疔散毒。主妇人腹内宿血,解天行火毒丹疔。洗疮疥,又能去风杀虫。"②《现代实用中药》:"用于痈疽疔肿化脓病。"③《苏州本产药材》:"解毒疏风。治目疾眩晕。"④《浙江中药手册》:"排脓解毒,消肿止痛。治痈肿疔毒,天泡湿疮。"⑤《江苏植药志》:"治霍乱,腹痛。"
甘草:性味:甘,平。归经:归心、肺、脾、胃经。功能主治:补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药。用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。
柴胡:性味:苦辛,凉。①《本草汇言》:"味苦辛,气凉,有小毒。"②《四川中药志》:"性微寒,味甘苦,无毒。"归经:《本草求真》:"入肺、肝。"功能主治:疏风清热,消肿解毒。治风热感冒,肺炎、白喉,胃肠炎:高血压,疔,痈,口疮,丹毒,湿疹,天泡疮。①《本草汇言》:"破血疏肝,解疔散毒。主妇人腹内宿血,解天行火毒丹疔。洗疮疥,又能去风杀虫。"②《现代实用中药》:"用于痈疽疔肿化脓病。"③《苏州本产药材》:"解毒疏风。治目疾眩晕。"④《浙江中药手册》:"排脓解毒,消肿止痛。治痈肿疔毒,天泡湿疮。"⑤《江苏植药志》:"治霍乱,腹痛。"
黄芪:性味:甘,温。归经:归肺、脾经。功能主治:补气固表,利尿托毒,排脓,敛疮生肌。用于气虚乏力,食少便溏,中气下陷,久泻脱肛,便血崩漏,表虚自汗,气虚水肿,痈疽难溃,久溃不敛,血虚痿黄,内热消渴;慢性肾炎蛋白尿,糖尿病。
决明子:性味:苦甘,凉。①《本经》:"味咸,平。"②《别录》:"苦甘,微寒,无毒。"③《本草正》:"味微苦微甘,性平,微凉。"归经:入肝、肾经。①《雷公炮制药性解》:"入肝经。"②《本草经疏》:"足厥阴肝,亦入胆、肾。"功能主治:清肝,明目,利水,通便。治风热赤眼,青盲,雀目,高血压,肝炎,肝硬化腹水,习惯性便秘。①《本经):"治青盲,目淫肤赤白膜,眼赤痛,泪出,久服益精光。"②《别录》:"疗唇口青。"③《药性论》:"利五脏,除肝家热。"④《日华子本草》:"助肝气,益精水;调末涂,消肿毒,熁太阳穴治头痛,又贴脑心止鼻衄;作枕胜黑豆,治头风,明目。"⑤《本草衍义补遗》:"解蛇毒。"⑥《生草药性备要》:"治小儿五疳,擦癣癞。"
桃枝:性味。味苦,性平。归经:归心、肝经。功效:活血通络,解毒杀虫。主治:用于心腹刺痛,风湿痹痛,跌打损伤,疮癣。
白菜根:性味:味甘、微苦,性平。功效:利小便,消炎肿。主治:用于尿路感染。
车前草:为车前草科植物车前及平车前的全株,味甘,性寒。具有利尿、清热、明目、祛痰的功效。主治小便不通、淋浊、带下、尿血、黄疸、水肿、热痢、泄泻、鼻衄、目赤肿痛、喉痹、咳嗽、皮肤溃疡等。
八角:性味:辛,温。功能主治:温中理气,健胃止呕。用于呕吐,腹胀,腹痛,疝气痛。
西洋参:性味:性凉,味甘、微苦。功能主治:补气养阴,清热生津。用于气虚阴亏,内热,咳喘痰血,虚热烦倦,消渴,口燥喉干。益肺阴,清虚火,生津止渴。治肺虚久嗽,失血,咽干口渴,虚热烦倦。
延胡索:性味:辛苦,温。①《海药本草》:"味苦甘,无毒。"②《开宝本草》:"味辛,温,无毒。"归经:入肝、胃经。①《汤液本草》:"入手足太阴经。"②《本草蒙筌》:"入太阴脾、肺,一云又走肝经。"③《雷公炮制药性解》:"入心、肺、脾、胃四经。"功能主治:活血,散瘀,理气,止痛。治心腹腰膝诸痛,月经不调,症瘕,崩中,产后血晕,恶露不尽,跌打损伤。
桔梗:性味:苦辛,平。①《本经》:"辛,微温。"②《别录》:"苦,有小毒。"③《药性论》:"苦,平,无毒。"归经:入肺、胃经。①《汤液本草》:"入足少阴、手太阴。"②《品汇精要》:"行足太阴经。"③《本草经疏》:"入手太阴、少阴,兼入足阳明胃经。"功能主治:开宣肺气,祛痰排脓。治外感咳嗽,咽喉肿痛,肺痈吐脓,胸满胁痛,痢疾腹痛。①《本经》:"主胸胁痛如刀刺,腹满,肠鸣幽幽,惊恐悸气。"②《别录》:"利五脏肠胃,补血气,除寒热、风痹,温中消谷,疗喉咽痛。"③《药性论》:"治下痢,破血,去积气,消积聚,痰涎,主肺热气促嗽逆,除腹中冷痛,主中恶及小儿惊痫。"④《日华子本草》:"下一切气,止霍乱转筋,心腹胀痛,补五劳,养气,除邪辟温,补虚消痰,破症瘕,养血排脓,补内漏及喉痹。"
川穹:性味:辛,温。①《本经》:"味辛,温。"②《吴普本草》:"黄帝、岐伯、雷公:辛,无毒,香。扁鹊:酸,无毒。李氏:生温,熟寒。"③《唐本草》:"味苦辛。"④《本草正》:"味辛微甘,气温。"归经:入肝、胆经。①《汤液本草》:"入手足厥阴经、少阳经。"②《药品化义》:"入肝、脾、三焦三经。"功能主治:行气开郁,法风燥湿,活血止痛。治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。用于月经不调,经闭痛经,瘕腹痛,胸胁刺痛,跌扑肿痛,头痛,风湿痹痛。
桃仁:性味:苦甘,平。①《本经》:"味苦,平。"②《别录》:"甘,无毒。"③《千金·食治》:"味苦甘辛,平,无毒。"归经:入心、肝、大肠经。①《汤液本草》:"入手、足厥阴经。"②《雷公炮制药性解》:"入肝、大肠二经。"③《本草经解》:"入手太阴肺经,手少阴心经,足太阴脾经。"功能主治:破血行瘀,润燥滑肠。治经闭,症瘕,热病蓄血,风痹,疟疾,跌打损伤,瘀血肿痛,血燥便秘。①《本经》:"主瘀血,血闭症瘕,邪气,杀小虫。"②《别录》:"止咳逆上气,消心下坚,除卒暴击血,破症瘕,通脉,止痛。"③孟诜:"杀三虫,止心痛。"④《医学启源》:"治大便血结。"⑤李杲:"治热入血室,腹中滞血,皮肤血热燥痒,皮肤凝聚之血。"
檀香:性味:辛,温。①《日华子本草》:"热,无毒。"②《珍珠囊》:"甘苦。"③《汤液本草》:"气温,味辛,无毒。"归经:入脾,胃、肺经。①《汤液本草》:"入手太阴,足少阴、阳明经。"②《本草通玄》:"脾,肺。"③《本草再新》:"入肝、脾、肺三经。"功能主治:理气,和胃。治心腹疼痛,噎膈呕吐,胸膈不舒。①陶弘警:"消风肿。"②《本草拾遗》:"主心腹霍乱,中恶,杀虫。"③《日华子本草》:"治心痛,霍乱。肾气腹痛,浓煎服;水磨敷外肾并腰肾痛处。"④《珍珠囊》:"引胃气上升,进食。"⑤《纲目》:"治噎膈吐食。又面生黑子,每夜以浆水洗拭令赤,磨汁涂之。"
三七:性味:甘微苦,温。①《纲目》:"甘微苦,温,无毒。"②《本草汇言》:"味甘微苦,性平,无毒。"归经:入肝、胃、大肠经。①《本草汇言》:"入阳明、厥阴经。"②《本草求真》:"入肝、胃,兼入心、大肠。"③《本草再新》:"入肺、肾二经。"功能主治:止血,散瘀,消肿,定痛。治吐血,咳血,衄血,便血,血痢,崩漏,症瘕,产后血晕,恶露不下,跌扑瘀血,外伤出血,痈肿疼痛。
瓜蒌:性味:甘、微苦、寒。归经:归肺、胃、大肠经。功能主治:清热涤痰,宽胸散结,润燥滑肠。用于肺热咳嗽,痰浊黄稠,胸痹心痛,结胸痞满,乳痈,肺痈,肠痈肿痛,大便秘结。
牛黄:性味:甘,凉。归经:归心、肝经。功能主治:清心,豁痰,开窍,凉肝,息风,解毒。用于热病神昏,中风痰迷,惊痫抽搐,癫痫发狂,咽喉肿痛,口舌生疮,痈肿疔疮。
夜交藤:性味:甘;微苦;性平。归经:心;肝经。功能主治:养心安神;祛风;通络。主失眠;多梦;血虚身痛;肌肤麻木;风湿痹痛;风疹瘙痒。
徐长卿:性味:辛,温。归经:归肝、胃经。功能主治:祛风化湿,止痛止痒。用于风湿痹痛,胃痛胀满,牙痛,腰痛,跌扑损伤,荨麻疹、湿疹。
玉米须:性味:甘、淡,平。归经:归膀胱、肝、胆经。功能主治:利尿消肿,平肝利胆。用于急、慢性肾炎,水肿,急、慢性肝炎,高血压,糖尿病,慢性鼻窦炎,尿路结石,胆道结石,小便不利、湿热黄胆等症。并可预防习惯性流产
银杏叶:性味:甘、苦、涩,平。归经:归心、肺经。功能主治:敛肺,平喘,活血化瘀,止痛。用于肺虚咳喘;冠心病,心绞痛,高血脂。
淫羊藿:性味:辛甘,温。①《别录》:"无毒。"②《药性论》:"味甘,平。"③《蜀本草》:"温。"④《滇南本草》:"性微温,味微辛。"归经:入肝、肾经。①《滇南本草》:"入肝、肾二经。"②《纲目》:"手、足阳明,三焦,命门。"③《本草经疏》:"入手厥阴,足少阴、厥阴。"功能主治:补肾壮阳,祛风除湿。治阳痿不举,小便淋沥,筋骨挛急,半身不遂,腰膝无力,风湿痹痛,四肢不仁。
葛根:性味:甘、辛,凉。归经:归脾、胃经。功能主治:解肌退热,生津,透疹,升阳止泻。用于外感发热头痛、项背强痛,口渴,消渴,麻疹不透,热痢,泄泻;高血压颈项强痛
羌活:性味:辛苦,温。①《药性论》:"味苦辛,无毒。"②《医学启源》:"《主治秘要》云:性温,味辛。"③《汤液本草》:"气微温,味苦甘,平。"归经:入膀胱、肾经。①《珍珠囊》:"足太阳膀胱经。"″手太阳小肠。"②《汤液本草》:"足太阳、厥阴经。"③《本草蒙筌》:"手、足太阳,足少阴、厥阴经。"功能主治:散表寒,祛风湿,利关节。治感冒风寒,头痛无汗,风寒湿痹,项强筋急,骨节酸疼,风水浮肿,痈疽疮毒。
红景天:性味:寒;甘;涩:归经:肺经。功能主治:补气清肺;益智养心;收涩止血;散瘀消肿。主气虚体弱;病后畏寒;气短乏力;肺热咳嗽;咯血;白带腹泻;跌打损伤;烫火伤;神经症;高原反应。
麦冬:性味:甘,微苦,微寒。归经:归心、肺、胃经。功能主治:养阴生津,润肺清心。用于肺燥干咳。虚痨咳嗽,津伤口渴,心烦失眠,内热消渴,肠燥便秘;咽白喉。
仙茅:性味:辛,温,有毒。①《海药本草》:"味甘,微沮,有小毒。"②《开宝本草,:"味辛,温,有毒。"③《滇南本草》:"性温,味辛微咸。"
④《纲目):"性热。"归经:入肾、肝经。①《滇南本草》:"入肾、肝二经。"②《本草求真》:"专入命门。"③《本草再新》:"入肺、肾二经。"功能主治:温肾阳,壮筋骨。治阳萎精冷,小便失禁,崩漏,心腹冷痛,腰脚冷痹,痈疽,瘰疬,阳虚冷泻。
川楝子:性味:苦,寒,有毒。①《本经》:"苦,寒。"②《别录》:"有小毒。"③《珍珠囊》:"酸,苦。"④《医林纂要》:"核:苦辛;寒。"归经:入肝、胃、小肠经。①《珍珠囊》:"入心。"②《雷公炮制药性解》:"入心、小肠二经。"③《本草经疏》:"入足阳明、手足太阴经。"④《得配本草》:"入足厥阴经。"功能主治:除湿热,清肝火,止痛,杀虫。治热厥心痛,胁痛,疝痛,虫积腹痛。
桂枝:性味:辛、甘,温。归经:归心、肺、膀胱经。功能主治:发汗解肌,温通经脉,助阳化气,平冲降气。用于风寒感冒,脘腹冷痛,血寒经闭,关节痹痛,痰饮,水肿,心悸,奔豚。
厚朴:性味:苦辛,温。①《本经》:"味苦,温。"②《别录》:"大温,无毒。"③《药性论》:"味苦辛,太热。"归经:入脾、胃、大肠经。①《雷公炮制药性解》:"入脾、胃二经。"②《本草经疏》:"入足太阴,手足阳明经。"③《本草经解》:"入足厥阴肝经、手少阴心经。"功能主治:温中,下气,燥湿,消痰。治胸腹痞满胀痛,反胃,呕吐,宿食不消,痰饮喘咳,寒湿泻痢。
罗勒:性味:味辛;甘;性温。归经:归肺;脾;胃;大肠经。功能主治:疏风解表;化湿和中;行气活血;解毒消肿。主感冒头痛;发热咳嗽;中暑;食积不化;不思饮食;脘腹胀满疼痛;哎吐泻痢;风湿痹痛;遗精;月经不调;牙痛口臭;胬肉遮睛;皮肤湿疮;瘾疹瘙痒;跌打损伤;蛇虫咬伤。
夏枯草:性味:辛、苦,寒。归经:归肝、胆经。功能主治:清火,明目,散结,消肿。用于目赤肿痛,目珠夜痛,头痛眩晕,瘰疬,瘿瘤,乳痈肿痛;甲状腺肿大,淋巴结结核,乳腺增生,高血压。
绞股蓝:性味:味苦;微甘;性凉。归经:归肺;脾;肾经。功能主治:清热;补虚;解毒。主体虚乏力;虚劳失精;白细胞减少症;高脂血症;病毒性肝炎;慢性胃肠炎;慢性气管炎。
花椒:性味:辛,温,有毒。①《本经》:"味辛,温。"②《别录》:"生温,热寒,有毒。"″太热,有毒。"③《药性论》:"味苦辛,有小毒。"归经:入脾、肺、肾经。①《纲目》:"手、足太阴,右肾命门气分。"②《本草经疏》:"入手、足太阴,兼入手厥阴经。"③《本草新编》:"入心、脾经。"④《长沙药解》:"入足阳明胃、足厥阴肝、足少阴肾、足太阴脾。"功能主治:温中散寒,除湿,止痛,杀虫,解鱼腥毒。治积食停饮,心腹冷痛,呕吐,噫呃,咳嗽气逆,风寒湿痹,泄泻,痢疾,疝痛,齿痛,蛔虫病,蛲虫病,阴痒,疮疥。
砂仁:性味:辛,温。①《药性论》:"味苦辛。"②《海药本草》:"味辛,平,咸。"③《开宝本草》:"味辛,温,无毒。"④《纲目》:"辛,温,涩,无毒。"归经:入脾、胃经。①《汤液本草》:"入手、足太阴、阳明、太阳,足少阴经。"②《本草经疏》:"入足太阴、阳明、厥阴、手太阴、阳明、厥阴。"③《本草再新》:"入心、脾二经。"功能主治:行气调中,和胃,醒脾。治腹痛痞胀,胃呆食滞,噎膈呕吐,寒泻冷痢,妊娠胎动
柏子仁:性味:甘,平。①《本经》:"味甘,平。"②《别录》:"无毒。"③《药性论》:"味辛甘。"④《本草正》:"味甘平,性微凉。"归经:入心、肝、脾经。①《雷公炮制药性解》:"入肺、脾、肾三经。"②《本草经疏》:"入足厥阴、少阴,亦入手少阴经。"③《本草新编》:"入心、肝、肾、膀胱四经。"功能主治:养心安神,润肠通便。治惊悸,失眠,遗精,盗汗,便秘。①《本经》:"主惊悸,安五藏,益气,除湿痹。"②《别录》:"疗恍惚,虚损吸吸,历节,腰中重痛,益血止汗。"③《药性论》:"能治腰肾中冷,膀胱中冷脓宿水,兴阳道,去头风,主小儿惊痫。"
石菖蒲:性味:辛,微温,①《本经》:"辛,温。"②《另口录》:"无毒。"③《药性论》:"味苦辛,无毒。"归经:入口、肝、脾经。①《纲目》:"手少阴、足厥阴。"②《雷公炮制药性解》:"入心、脾、膀胱三经。"③《本草经解》:"入足厥阴肝经、手太阴肺经。"功能主治:开窍,豁痰,理气,活血,散风,去湿。治癫痫,痰厥,热病神昏,健忘,气闭耳聋,心胸烦闷,胃痛,腹痛,风寒湿痹,痈疽肿毒,跌打损伤。
半夏:性味:辛,温;有毒。归经:归脾、胃、肺经。功能主治:燥湿化痰,降逆止呕,消痞散结。用于痰多咳喘,痰饮眩悸,风痰眩晕,痰厥头痛,呕吐反胃,胸脘痞闷,梅核气;生用外治痈肿痰核。姜半夏多用于降逆止呕。
下面结合具体实施例对本发明做进一步阐述。
实施例1
a、取山茱萸1份、党参2份、山楂1份、金银花1份、生地1份、高良姜1份、五味子2份、益母草3份、野菊花3份、甘草3份、柴胡1份、黄芪1份、决明子1份、桃枝1份、白菜根1份、车前草3份、八角1份、西洋参1份、延胡索1份、桔梗2份、川穹1份、桃仁2份、檀香1份、三七1份、瓜蒌2份、牛黄1份、夜交藤1份、徐长卿2份、玉米须1份、银杏叶3份、淫羊藿3份、葛根1份、羌活2份、红景天1份、麦冬3份、仙茅1份、川楝子1份、桂枝3份、厚朴2份、罗勒1份、夏枯草3份、绞股蓝2份、花椒2份、砂仁1份、柏子仁1份、石菖蒲1份、半夏1份原料加入5-10倍量的乙醇中浸泡1-2小时,加热提取2次,每次0.5小时,去上清液,合并提取液,100-180目滤过,再经截流分子量为5000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.10的浸膏,加热浓缩至膏状,静置备用,成为组分1;
b、将乙醇提取过的药渣放入5倍量水中,加热回流提取2次,每次提取时间为0.5小时,100-120目滤过,再经截流分子量为5000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.10的浸膏,加热浓缩至膏状,静置备用,成为组分2;
c、将上述两种组分膏状浓缩成糊状,浓缩液用CO60灭菌,辐照剂量8k,加入糊精,然后真空罐装密封即得,使用时直接饮用。
实施例2
a.将所述原料药混合,切碎,过120目筛,得细药粉备用
b、取山茱萸1份、党参2份、山楂1份、金银花1份、生地1份、高良姜1份、五味子2份、益母草3份、野菊花3份、甘草3份、柴胡1份、黄芪1份、决明子1份、桃枝1份、白菜根1份、车前草3份、八角1份、西洋参1份、延胡索1份、桔梗2份、川穹1份、桃仁2份、檀香1份、三七1份、瓜蒌2份、牛黄1份、夜交藤1份、徐长卿2份、玉米须1份、银杏叶3份、淫羊藿3份、葛根1份、羌活2份、红景天1份、麦冬3份、仙茅1份、川楝子1份、桂枝3份、厚朴2份、罗勒1份、夏枯草3份、绞股蓝2份、花椒2份、砂仁1份、柏子仁1份、石菖蒲1份、半夏1份原料细粉加入5-10倍量的乙醇中浸泡1-2小时,加热提取2次,每次1-2小时,去上清液,合并提取液,100-180目滤过,再经截流分子量为5000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.10的浸膏,加热浓缩至膏状,静置备用,成为组分1;
c、将乙醇提取过的药渣放入10倍量水中,加热回流提取1次,每次提取时间为1~2小时,100-120目滤过,再经截流分子量为5000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.10的浸膏,加热浓缩至膏状,静置备用,成为组分2;
d、将上述两种提取液合并,减压回收乙醇并喷雾干燥,得药粉;混合过筛得到的细粉装入胶囊制为胶囊剂。
实施例3
a.将所述原料药混合,切碎,过120目筛,得细药粉备用
b、取山茱萸1份、党参2份、山楂1份、金银花1份、生地1份、高良姜1份、五味子2份、益母草3份、野菊花3份、甘草3份、柴胡1份、黄芪1份、决明子1份、桃枝1份、白菜根1份、车前草3份、八角1份、西洋参1份、延胡索1份、桔梗2份、川穹1份、桃仁2份、檀香1份、三七1份、瓜蒌2份、牛黄1份、夜交藤1份、徐长卿2份、玉米须1份、银杏叶3份、淫羊藿3份、葛根1份、羌活2份、红景天1份、麦冬3份、仙茅1份、川楝子1份、桂枝3份、厚朴2份、罗勒1份、夏枯草3份、绞股蓝2份、花椒2份、砂仁1份、柏子仁1份、石菖蒲1份、半夏1份原料加入5-10倍量的乙醇中浸泡1-2小时,加热提取2次,每次1-2小时,去上清液,合并提取液,100-180目滤过,再经截流分子量为5000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.10的浸膏,加热浓缩至膏状,静置备用,成为组分1;
c、将乙醇提取过的药渣放入10倍量水中,加热回流提取1次,每次提取时间为1~2小时,100-120目滤过,再经截流分子量为5000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.10的浸膏,加热浓缩至膏状,静置备用,成为组分2;
d.将上述两种提取液合并,减压回收乙醇成浸膏,与a步骤得到细药粉合并加入蜂蜜搓成丸剂。
本发明药物组合物的动物毒性试验
1、应用小鼠进行急性毒性实验表明:小鼠口服灌胃本发明的中药制剂口服液,在488.8g生药/kg剂量下,给药后小鼠出现轻微活动减少,1小时左右恢复正常,给药后连续观察7天,无一动物死亡,其全身状况、饮食、摄水、小便和体重增长均正常,实验结果表明:小鼠口服灌胃本发明的中药制剂口服液的最大给药量为488.8g生药/kg/d(LD50>488.8g生药/kg)。本发明的中药制剂每日临床用药总量为0.1g生药/kg/d;按体重计,小鼠灌胃本发明的中药制剂的耐受量为临床病人的4888倍。提示该药急性毒性低,临床用药安全。
2、选用SD大鼠,给予不同浓度(18.0、6.0、2.0g生药/kg)的本发明的中药制剂丸剂,每天灌胃一次,连续90天,末次给药后24小时各组活杀1/2动物(雌雄各半),其余1/2动物继续观察2周后活杀。试验期间观察动物的外观、一般行为、摄食量、体重变化,给药后90天和停药2周进行血液学(RBC、HB、网织红细胞、PLT、CT、WBC及分类)和血液生化(AST、ALT、ALP、Glu、BUN、Crea、TP、T.BIL、ALB、CHOL)、尿液生化、脏器系数、病理组织学等指标检查。试验结果表明:本发明的中药制剂在高、中、低剂量组动物一般状态良好,外观体征、行为活动、进食量和体重增长均无异常变化;三个剂量组及对照组血液学检查、血液生化学、尿液生化检查均在正常范围,组间无显著差异;各组主要脏器组织病理学检查未见明显异常。上述指标停药2周后也未见改变。本试验用药剂量分别为临床用药剂量的180、60、20倍,根据试验结果本发明的中药制剂在高、中、低三个剂量(18.0、6.0、2.0g生药/kg)连续90天给药对大鼠无明显影响,无明确的毒性靶器官和敏感指标,恢复期观察也未见延迟性毒性反应,提示本发明的中药制剂临床应用的剂量安全性较高。
3、选用SD大鼠,给予不同浓度(18.0、6.0、2.0g生药/kg)的本发明的中药制剂胶囊剂,每天灌胃一次,连续90天,末次给药后24小时各组活杀1/2动物(雌雄各半),其余1/2动物继续观察2周后活杀。试验期间观察动物的外观、一般行为、摄食量、体重变化,给药后90天和停药2周进行血液学(RBC、HB、网织红细胞、PLT、CT、WBC及分类)和血液生化(AST、ALT、ALP、Glu、BUN、Crea、TP、T.BIL、ALB、CHOL)、尿液生化、脏器系数、病理组织学等指标检查。试验结果表明:本发明的中药制剂在高、中、低剂量组动物一般状态良好,外观体征、行为活动、进食量和体重增长均无异常变化;三个剂量组及对照组血液学检查、血液生化学、尿液生化检查均在正常范围,组间无显著差异;各组主要脏器组织病理学检查未见明显异常。上述指标停药2周后也未见改变。本试验用药剂量分别为临床用药剂量的180、60、20倍,根据试验结果本发明的中药制剂在高、中、低三个剂量(18.0、6.0、2.0g生药/kg)连续90天给药对大鼠无明显影响,无明确的毒性靶器官和敏感指标,恢复期观察也未见延迟性毒性反应,提示本发明的中药制剂临床应用的剂量安全性较高。
药理学实验说明:
本发明中药组合物于2010年至2015年临床观察冠心病230例患者,临床报告如下:
1、一般资料230例患者中,年龄22-50岁,病程多在3个月到10年,平均年龄30岁。
2、诊断标准
参照1999年美国心脏病学会(ACC)/美国心脏协会(AHA)/美国医师学会及美国内科学会(ACP-ASIM)联合协定关于《慢性稳定性诊治指南》2002年(ACC/AHA)《不稳定型无ST段抬高心肌梗死诊疗指南》。
3、治疗方法
对照组以消心痛治疗,治疗组本发明中药制剂治疗。对照组以消心痛,于发病时开始服药,疼痛症状完全消失后可以停药。实验组服用本发明实施例3的丸剂药物,每日两次,每次一粒,两周为一个疗程。
4、治疗结果:
4.1参照《中医药新药临床研究指导原则》制定,显效:冠心病阳性体征全部消失,心电图及心脏其它检查趋于正常,一年内未复发;有效:冠心病阳性体征基本消失,心电图及心脏其它检查趋于正常,一年内有复发,但间隔时间长,疼痛程度较之前明显减轻;无效:冠心病阳性体征未消失,心电图及心脏其它检查无好转。
4.2结果
组别 | N | 治愈 | 有效 | 无效 | 总有效 |
治疗组 | 130 | 80 | 46 | 4 | 96.9% |
对照组 | 100 | 41 | 37 | 22 | 78.0% |
注:与对照组比较,①P<0.01临床资料。
以上所述,仅是本发明的最佳实施例而已,并非对本发明作任何形式上的限制,任何熟悉本领域的技术人员,在不脱离本发明技术方案范围情况下,利用上述揭示的方法内容对本发明技术方案做出许多可能的变动和修饰,均属于权利要求书保护的范围。
Claims (10)
1.一种用于治疗冠心病的中药制剂,其特征在于:由以下重量份数的各组分组成:
山茱萸1-30份、党参1-30份、山楂1-30份、金银花1-30份、生地1-30份、高良姜1-30份、五味子1-30份、益母草1-30份、野菊花1-30份、甘草1-30份、柴胡1-30份、黄芪1-30份、决明子1-30份、桃枝1-30份、白菜根1-30份、车前草1-30份、八角1-30份、西洋参1-30份、延胡索1-30份、桔梗1-30份、川穹1-30份、桃仁1-30份、檀香1-30份、三七1-30份、瓜蒌1-30份、牛黄1-30份、夜交藤1-30份、徐长卿1-30份、玉米须1-30份、厚朴1-30份、银杏叶1-30份、淫羊藿1-30份、葛根1-30份、羌活1-30份、红景天1-30份、麦冬1-30份、仙茅1-30份、川楝子1-30份、桂枝1-30份、罗勒1-30份、夏枯草1-30份、绞股蓝1-30份、花椒1-30份、砂仁1-30份、柏子仁1-30份、石菖蒲1-30份、半夏1-30份。
2.根据权利要求1所述的一种用于治疗冠心病的中药制剂,其特征在于:由以下重量份数的各组分组成:
山茱萸1-15份、党参1-15份、山楂1-15份、金银花1-15份、生地1-15份、高良姜1-15份、五味子1-15份、益母草1-15份、野菊花1-15份、甘草1-15份、柴胡1-15份、黄芪1-15份、决明子1-15份、桃枝1-15份、白菜根1-15份、车前草1-15份、八角1-15份、西洋参1-15份、延胡索1-15份、桔梗1-15份、川穹1-15份、桃仁1-15份、檀香1-15份、三七1-15份、瓜蒌1-15份、牛黄1-15份、夜交藤1-15份、徐长卿1-15份、玉米须1-15份、厚朴1-15份、银杏叶1-15份、淫羊藿1-15份、葛根1-15份、羌活1-15份、红景天1-15份、麦冬1-15份、仙茅1-15份、川楝子1-15份、桂枝1-15份、罗勒1-15份、夏枯草1-15份、绞股蓝1-15份、花椒1-15份、砂仁1-15份、柏子仁1-15份、石菖蒲1-15份、半夏1-15份。
3.根据权利要求1至2所述的一种用于治疗冠心病的中药制剂,其特征在于:由以下重量份数的各组分组成:
山茱萸1-10份、党参1-10份、山楂1-10份、金银花1-10份、生地1-10份、高良姜1-10份、五味子1-10份、益母草1-10份、野菊花1-10份、甘草1-10份、柴胡1-10份、黄芪1-10份、决明子1-10份、桃枝1-10份、白菜根1-10份、车前草1-10份、八角1-10份、西洋参1-10份、延胡索1-10份、桔梗1-10份、川穹1-10份、桃仁1-10份、檀香1-10份、三七1-10份、瓜蒌1-10份、牛黄1-10份、夜交藤1-10份、徐长卿1-10份、玉米须1-10份、厚朴1-10份、银杏叶1-10份、淫羊藿1-10份、葛根1-10份、羌活1-10份、红景天1-10份、麦冬1-10份、仙茅1-10份、川楝子1-10份、桂枝1-10份、罗勒1-10份、夏枯草1-10份、绞股蓝1-10份、花椒1-10份、砂仁1-10份、柏子仁1-10份、石菖蒲1-10份、半夏1-10份。
4.根据权利要求1至3所述的一种用于治疗冠心病的中药制剂,其特征在于:所述中药制剂的剂型为:片剂、糖衣片剂、薄膜衣片剂、肠溶衣片剂、硬胶囊剂、软胶囊剂、口服液、口含剂、颗粒剂、冲剂、蜜丸剂、散剂、丹剂、溶液剂、注射剂、栓剂、硬膏剂或糖浆剂。
5.根据权利要求1至4所述的一种用于治疗冠心病的中药制剂的制备方法,其特征在于:所述制剂剂型为口服液剂,其制备方法的包括:
a、取原料放入乙醇中浸泡,热提取2次,成膏状,为组分1;
b、药渣水提取2次,浓缩过滤为膏状,为组分2;
c、将上述两种膏状浓缩成糊状,灭菌,加入糊精,然后真空冷冻密封。
6.根据权利要求5所述的一种用于治疗冠心病的中药制剂的制备方法,其特征在于:所述步骤a中,取原料加入5-10倍量的乙醇中浸泡1-2小时,加热提取2次,每次0.5小时,去上清液,合并提取液,100-180目滤过,再经截流分子量为5000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.10的浸膏,加热浓缩至膏状,静置备用,成为组分1。
7.根据权利要求5所述的一种用于治疗冠心病的中药制剂的制备方法,其特征在于:所述步骤b中,将乙醇提取过的药渣放入5倍量水中,加热回流提取2次,每次提取时间为0.5小时,100-120目滤过,再经截流分子量为5000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.10的浸膏,加热浓缩至膏状,静置备用,成为组分2。
8.根据权利要求5所述的一种用于治疗冠心病的中药制剂的制备方法,其特征在于:所述步骤c中,将上述两种组分膏状浓缩成糊状,浓缩液用CO60灭菌,辐照剂量8k,加入糊精,然后真空罐装密封即得,使用时直接饮用。
9.一种如权利要求1至8所述的治疗冠心病的中药制剂的制备方法,其特征在于,所述制剂剂型为胶囊剂,其制备方法的包括:
a.将所述原料放入粉碎机粉碎后过筛;
b.将过筛后剩下的颗粒物放入乙醇中加热回流提取2次;
c.再取上述乙醇提取后的药渣,加水加热回流提取1次;
d.将上述两种提取液合并,减压回收乙醇并喷雾干燥,得药粉;混合过筛得到的细粉装入胶囊制为胶囊剂。
10.一种如权利要求1至9所述的治疗冠心病的中药制剂的制备方法,其特征在于,所述内服药物的剂型为丸剂,其制备步骤包括:
a.将所述原料药混合,切碎,过120目筛,得细药粉备用;
b.将未过筛的粗粉浸泡乙醇中提取2次;
c.再取上述步骤提取后的药渣,加水加热回流提取1次;
d.将上述两种提取液合并,减压回收乙醇成浸膏,与a步骤得到细药粉合并加入蜂蜜搓成丸剂。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610023875.2A CN105641593A (zh) | 2016-01-14 | 2016-01-14 | 一种用于治疗冠心病的中药制剂及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610023875.2A CN105641593A (zh) | 2016-01-14 | 2016-01-14 | 一种用于治疗冠心病的中药制剂及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105641593A true CN105641593A (zh) | 2016-06-08 |
Family
ID=56487362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610023875.2A Withdrawn CN105641593A (zh) | 2016-01-14 | 2016-01-14 | 一种用于治疗冠心病的中药制剂及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105641593A (zh) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102988675A (zh) * | 2012-12-28 | 2013-03-27 | 青岛华仁信息技术开发有限公司 | 一种治疗慢性前列腺炎的中药组合物及其制备方法 |
CN103007234A (zh) * | 2012-12-28 | 2013-04-03 | 青岛华仁信息技术开发有限公司 | 一种治疗子宫内膜异位引起痛经的中药制剂及其制备方法 |
CN104826033A (zh) * | 2015-06-01 | 2015-08-12 | 青岛友诚高新技术有限公司 | 一种治疗冠心病的中药组合物及其制备方法 |
-
2016
- 2016-01-14 CN CN201610023875.2A patent/CN105641593A/zh not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102988675A (zh) * | 2012-12-28 | 2013-03-27 | 青岛华仁信息技术开发有限公司 | 一种治疗慢性前列腺炎的中药组合物及其制备方法 |
CN103007234A (zh) * | 2012-12-28 | 2013-04-03 | 青岛华仁信息技术开发有限公司 | 一种治疗子宫内膜异位引起痛经的中药制剂及其制备方法 |
CN104826033A (zh) * | 2015-06-01 | 2015-08-12 | 青岛友诚高新技术有限公司 | 一种治疗冠心病的中药组合物及其制备方法 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102048933B (zh) | 一种治疗小儿腹泻的中药组合物及其制备方法 | |
CN102078520B (zh) | 一种治疗神经性头痛的中药制剂及其制备方法 | |
CN105749179A (zh) | 治疗代谢综合征的中药组合物 | |
CN106267120A (zh) | 一种治疗鼻炎的中药制剂及其制备方法 | |
CN103041256B (zh) | 一种治疗小儿反复呼吸道感染的中药制剂 | |
CN104398991A (zh) | 一种治疗奶牛缺乳症的药物组合物及其制备方法 | |
CN105497816A (zh) | 一种治疗动脉粥样硬化的中药制剂及其制备方法 | |
CN105311581A (zh) | 一种预防和治疗乳腺增生的中药组合物及其制备方法 | |
CN103041257B (zh) | 治疗小儿发热高烧呼吸道感染的中药制剂 | |
CN103041255B (zh) | 治疗小儿咽喉肿痛呼吸道感染的中药制剂 | |
CN103301341A (zh) | 一种治疗缺血性脑中风的中药组合物 | |
CN105435131A (zh) | 一种治疗慢性心衰的中药组合物及其制备方法 | |
CN106267028A (zh) | 一种治疗肺炎的中药组合物及其制备方法 | |
CN104435962A (zh) | 用于治疗仔猪消化不良性下痢的药物组合物及其制备方法 | |
CN104800780A (zh) | 一种治疗多囊卵巢综合征的中药制剂及其制备方法 | |
CN103041258B (zh) | 治疗小儿呼吸道感染伴纳差不食的中药制剂 | |
CN103007145A (zh) | 一种治疗小儿轮状病毒肠炎的中药组合物及其制备方法 | |
CN103656199B (zh) | 一种治疗肾阴不足证型咳嗽的中药 | |
CN106166251A (zh) | 一种用于治疗哮喘的中药制剂及其制备方法 | |
CN105381414A (zh) | 一种治疗乳房肿块及囊性增生的中药制剂及其制备方法 | |
CN105641593A (zh) | 一种用于治疗冠心病的中药制剂及其制备方法 | |
CN105311527A (zh) | 一种用于治疗子宫内膜移位症的中药制剂及其制备方法 | |
CN105456933A (zh) | 一种活血化瘀、通经活络的中药及其制备方法 | |
CN105267940A (zh) | 一种预防和治疗胃溃疡的中药组合物及其制备方法 | |
CN105770760A (zh) | 主治胃溃疡的制剂及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160608 |