CN105641514A - 一种治疗麦粒肿的复方中药制剂及其制备方法 - Google Patents
一种治疗麦粒肿的复方中药制剂及其制备方法 Download PDFInfo
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- CN105641514A CN105641514A CN201610033560.6A CN201610033560A CN105641514A CN 105641514 A CN105641514 A CN 105641514A CN 201610033560 A CN201610033560 A CN 201610033560A CN 105641514 A CN105641514 A CN 105641514A
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Abstract
本发明公开的是一种治疗麦粒肿的复方中药制剂及其制备方法，所述一种治疗麦粒肿的复方中药制剂按重量份计，是由以下原料组成：葫芦茶根8～20份、望江青10～15份、兔毛蒿6～15份、岩谷伞6～14份、蚌兰叶5～15份、对叶草6～12份、铺地黍5～9份、匍匐滨藜6～10份、甜瓜叶2～8份、葡萄籽1～7份、锯齿草3～5份、冻青叶1～5份、光叶水苏2～5份、榈木1～3份、穿心莲1～4份、滇苦菜2～3份。本发明依据祖国传统中医理论，结合多年临床姜燕，配方独特，各药材之间组分配伍合理，具有清热解毒，拔毒消肿，抗菌消炎，清心明目，滋养眼部皮肤的功效，对于麦粒肿有独特的疗效，不仅见效快，而且无副作用。
Description
技术领域
本发明涉及中药技术领域，具体是涉及一种治疗麦粒肿的复方中药制剂及其制备方法。
背景技术
麦粒肿又名睑腺炎，俗称“针眼”，多发于青年人。此病顽固，且易复发，严重时可遗留眼脸疤痕。患脸缘炎、沙眼、慢性结膜炎或过度用眼以及有近视、远视、散光等眼病时，没有及时配镜矫正，并眼睛疲劳时亦可发病。麦粒肿表现为眼皮有小疖，微痒，局部红肿、热、痛、小疖成熟时，可自行溃破流脓。
中医将麦粒肿称为针眼，中医认为，麦粒肿是因风热毒邪，客于胞睑而化热，风热煎灼津液，变生疮疖，或因过食辛辣刺激性食物，脾胃蕴积热毒，郁久化火，或外受风热火毒，热毒上攻睑胞，使气血壅滞而成，以局部红肿、疼痛，出现硬结及黄色脓点为主要临床表现，睑缘局部张力增高，睑缘疼痛，然后形成一个小圆形有触痛感的肿胀区，眼泪增多，畏光并有异物感。此病顽固，若余邪未清，热毒蕴伏，或素体虚弱，卫外不固而易感风邪者，常反复发作，严重时可遗留眼脸疤痕。目前，治疗麦粒肿的中药较多，但存在疗效不明显、易复发等缺点。
目前治疗麦粒肿一般是目前靠吃西药，副作用大，依赖性强，导致药量越来越大，造成恶性循环。
发明内容
本发明解决的技术问题是提供一种治疗麦粒肿的复方中药制剂及其制备方法，该复方中药制剂配方独特，能快速有效治疗麦粒肿，无副作用。
本发明的技术方案是：一种治疗麦粒肿的复方中药制剂，按重量组份计，是由以下原料组成：葫芦茶根8～20份、望江青10～15份、兔毛蒿6～15份、岩谷伞6～14份、蚌兰叶5～15份、对叶草6～12份、铺地黍5～9份、匍匐滨藜6～10份、甜瓜叶2～8份、葡萄籽1～7份、锯齿草3～5份、冻青叶1～5份、光叶水苏2～5份、榈木1～3份、穿心莲1～4份、滇苦菜2～3份。
优选配比为：葫芦茶根14份、望江青12.5份、兔毛蒿10.5份、岩谷伞10份、蚌兰叶10份、对叶草9份、铺地黍7份、匍匐滨藜8份、甜瓜叶5份、葡萄籽4份、锯齿草4份、冻青叶3份、光叶水苏3.5份、榈木2份、穿心莲2.5份、滇苦菜2.5份。
所述的一种治疗麦粒肿的复方中药制剂的制备方法，包括以下步骤：
(1)按配方称取葫芦茶根、望江青、铺地黍、岩谷伞、匍匐滨藜、榈木、锯齿草、穿心莲、滇苦菜，用流动的自来水冲洗干净，晾干，用水提取2～3次，合并提取液，浓缩至相对密度为1.10～1.20，按1:(1.0～1.2)的体积比加入浓度为50～60％的乙醇低温冷藏静置处理10～30小时，滤过，回收乙醇，用明胶作为絮凝剂除去色素，浓缩成70℃下相对密度为0.75～0.95的清膏,得到中药有效成分a，待用；
(2)按配方称取蚌兰叶、冻青叶，用流动的自来水冲洗干净，晾干，用粉碎机粉碎成20～40目的粗粉，置于干燥机内干燥至含水量低于3％，取出，晾凉，超微粉碎至200～300目，得到有效成分b，待用；
(3)按配方称取新鲜的兔毛蒿、甜瓜叶、对叶草、光叶水苏，洗净，入榨机榨出汁液，冷藏，过滤，除去杂质和沉淀，脱色处理，浓缩至含水量为40～45％，再加入0.1～0.2％的抗氧化剂，得到有效成分c，待用；
(4)按配方称取葡萄籽，粉碎，用5～7倍量的质量浓度为65％的甲醇，在60～70℃回流提取3次，每次提取30～60min，冷却抽滤，合并滤液，减压回收至无溶媒滴出，提取出葡萄籽油，得到有效成分d，待用；
(5)在配药罐中将上述所制得的中药有效成分a、中药有效成分b、中药有效成分c、有效成分d混合，得到总有效成分，按1:4.5～6.3的重量比例加入注射用水，再加入0.4～1.0％的表面活性剂、0.01～0.05％的助悬剂、0.01～0.02％的稳定剂，超声分散25～28分钟，高压蒸汽灭菌，分装于喷雾容器中，即可。
进一步地，所述表面活性剂为氯化十六烷基吡啶(CPC)或吐温80。
进一步地，所述助悬剂为甲基纤维素、壳聚糖、西黄蓍胶、卡波姆或聚维酮中的任意一种或几种。
进一步地，所述所述稳定剂为泊洛沙姆407。
进一步地，所述步骤(5)中高压蒸汽灭菌的压力为101～103KPa，温度为121℃，持续时间为8～15分钟。
本发明所选中药材的研究现状如下：
葫芦茶根:【性味】《贵州草药》："性平，味微苦辛。"【功能主治】清热解毒,拔毒散结。治风热咳嗽，肺痈，黄疸，痈肿，瘰疬，骨痨。
望江青:【性味】味甘；苦；性凉【归经】肺经【功能主治】清热解毒；凉血活血。主咽喉肿痛；肺痈；百日咳；痢疾；乳痈；带状疱疹；目生翳障；咯血；跌打肿痛。
兔毛蒿:【性味】苦，寒。【功能主治】清热解毒，抗菌消炎，安神镇惊，调经止血。
岩谷伞：【性味】辛苦，平。【功能主治】镇静安神，清心明目。
蚌兰叶:【性味】甘，凉。【功能主治】止血，去瘀。
对叶草：【性味】苦，温，有毒。【功能主治】活血，止痛，消炎。
铺地黍：【性味】甘，平。【功能主治】清热平肝，利湿解毒。
匍匐滨藜：【性味】微苦；性凉。【功能主治】祛风除湿，活血通经，解毒消肿药主治，风湿痹痛，带下，月经不调，疮疡痈，皮炎。
甜瓜叶:【性味】味甘；性寒。【功能主治】祛瘀；消肿。
葡萄籽：含有丰富的多种氨基酸、维生素及矿物质等具有保健、美容之功效。
锯齿草：味淡，性平；清热解毒，祛瘀消肿，止痛；用于毒蛇咬伤，跌打损伤，产后瘀血腹痛；外用治疮疖肿痛。
冻青叶，【性味】苦；涩；凉。【功能主治】清热解毒；消肿止痛；主痄腮；疮毒；水火烫伤；风湿痹痛；跌打骨折。
光叶水苏，【性味】味微甘，性平。【功能主治】清热化痰，抗菌消炎；治风热咳嗽，咽喉肿痛，百日咳，痢疾，带状疱疹。
榈木：味辛，性温，无毒；祛风除湿，活血破瘀，解毒消肿；主风湿性关节炎，腰肌劳损，产后瘀血腹痛，赤白漏下，跌打损伤，骨折，感冒，毒蛇咬伤，无名肿毒。
穿心莲：解热，泻火，燥湿，抗菌消炎。
滇苦菜，【性味】苦，寒。【功能主治】清热解毒，凉血止血；用于肠炎，痢疾，急性黄疸型传染性肝炎，阑尾炎，乳腺炎，口腔炎，咽炎，扁桃体炎，吐血，衄血，咯血，便血，崩漏；外用治痈疮肿毒，中耳炎。
本发明的有益效果是：本发明依据祖国传统中医理论，结合多年临床姜燕，配方独特，各药材之间组分配伍合理，具有清热解毒，拔毒消肿，抗菌消炎，清心明目，滋养眼部皮肤的功效，对于麦粒肿有独特的疗效，不仅见效快，而且无副作用。
具体实施方式
实施例1：
一种治疗麦粒肿的复方中药制剂，按重量组份计，是由以下原料组成：葫芦茶根8份、望江青10份、兔毛蒿6份、岩谷伞6份、蚌兰叶5份、对叶草6份、铺地黍5份、匍匐滨藜6份、甜瓜叶2份、葡萄籽1份、锯齿草3份、冻青叶1份、光叶水苏2份、榈木1份、穿心莲1份、滇苦菜2份。
该治疗麦粒肿的复方中药制剂的制备方法，包括以下步骤：
(1)按配方称取葫芦茶根、望江青、铺地黍、岩谷伞、匍匐滨藜、榈木、锯齿草、穿心莲、滇苦菜，用流动的自来水冲洗干净，晾干，用水提取2次，合并提取液，浓缩至相对密度为1.10，按1:1.0的体积比加入浓度为50％的乙醇低温冷藏静置处理10小时，滤过，回收乙醇，用明胶作为絮凝剂除去色素，浓缩成70℃下相对密度为0.75的清膏,得到中药有效成分a，待用；
(2)按配方称取蚌兰叶、冻青叶，用流动的自来水冲洗干净，晾干，用粉碎机粉碎成20目的粗粉，置于干燥机内干燥至含水量低于3％，取出，晾凉，超微粉碎至200目，得到有效成分b，待用；
(3)按配方称取新鲜的兔毛蒿、甜瓜叶、对叶草、光叶水苏，洗净，入榨机榨出汁液，冷藏，过滤，除去杂质和沉淀，脱色处理，浓缩至含水量为40％，再加入0.1％的抗氧化剂，得到有效成分c，待用；
(4)按配方称取葡萄籽，粉碎，用5倍量的质量浓度为65％的甲醇，在60℃回流提取3次，每次提取30min，冷却抽滤，合并滤液，减压回收至无溶媒滴出，提取出葡萄籽油，得到有效成分d，待用；
(5)在配药罐中将上述所制得的中药有效成分a、中药有效成分b、中药有效成分c、有效成分d混合，得到总有效成分，按1:4.5的重量比例加入注射用水，再加入0.4％的表面活性剂、0.01％的助悬剂、0.01％的稳定剂，超声分散25分钟，高压蒸汽灭菌，灭菌的压力为101KPa，温度为121℃，持续时间为8分钟，灭菌完成后分装于喷雾容器中，即可。所述表面活性剂为氯化十六烷基吡啶(CPC)或吐温80；所述助悬剂为甲基纤维素、壳聚糖、西黄蓍胶、卡波姆或聚维酮；所述所述稳定剂为泊洛沙姆407。
实施例2：
一种治疗麦粒肿的复方中药制剂，按重量组份计，是由以下原料组成：葫芦茶根14份、望江青12.5份、兔毛蒿10.5份、岩谷伞10份、蚌兰叶10份、对叶草9份、铺地黍7份、匍匐滨藜8份、甜瓜叶5份、葡萄籽4份、锯齿草4份、冻青叶3份、光叶水苏3.5份、榈木2份、穿心莲2.5份、滇苦菜2.5份。
该治疗麦粒肿的复方中药制剂的制备方法，包括以下步骤：
(1)按配方称取葫芦茶根、望江青、铺地黍、岩谷伞、匍匐滨藜、榈木、锯齿草、穿心莲、滇苦菜，用流动的自来水冲洗干净，晾干，用水提取2次，合并提取液，浓缩至相对密度为1.15，按1:1.1的体积比加入浓度为55％的乙醇低温冷藏静置处理20小时，滤过，回收乙醇，用明胶作为絮凝剂除去色素，浓缩成70℃下相对密度为0.85的清膏,得到中药有效成分a，待用；
(2)按配方称取蚌兰叶、冻青叶，用流动的自来水冲洗干净，晾干，用粉碎机粉碎成30目的粗粉，置于干燥机内干燥至含水量低于3％，取出，晾凉，超微粉碎至220目，得到有效成分b，待用；
(3)按配方称取新鲜的兔毛蒿、甜瓜叶、对叶草、光叶水苏，洗净，入榨机榨出汁液，冷藏，过滤，除去杂质和沉淀，脱色处理，浓缩至含水量为42.5％，再加入0.15％的抗氧化剂，得到有效成分c，待用；
(4)按配方称取葡萄籽，粉碎，用6倍量的质量浓度为65％的甲醇，在65℃回流提取3次，每次提取45min，冷却抽滤，合并滤液，减压回收至无溶媒滴出，提取出葡萄籽油，得到有效成分d，待用；
(5)在配药罐中将上述所制得的中药有效成分a、中药有效成分b、中药有效成分c、有效成分d混合，得到总有效成分，按1:5.4的重量比例加入注射用水，再加入0.7％的表面活性剂、0.03％的助悬剂、0.015％的稳定剂，超声分散26.5分钟，高压蒸汽灭菌，灭菌的压力为102KPa，温度为121℃，持续时间为11.5分钟，灭菌完成后分装于喷雾容器中，即可。所述表面活性剂为氯化十六烷基吡啶(CPC)或吐温80；所述助悬剂为甲基纤维素、壳聚糖、西黄蓍胶、卡波姆或聚维酮；所述所述稳定剂为泊洛沙姆407。
实施例3：
一种治疗麦粒肿的复方中药制剂，按重量组份计，是由以下原料组成：葫芦茶根20份、望江青15份、兔毛蒿15份、岩谷伞14份、蚌兰叶15份、对叶草12份、铺地黍9份、匍匐滨藜10份、甜瓜叶8份、葡萄籽7份、锯齿草5份、冻青叶5份、光叶水苏5份、榈木3份、穿心莲4份、滇苦菜3份。
该治疗麦粒肿的复方中药制剂的制备方法，包括以下步骤：
(1)按配方称取葫芦茶根、望江青、铺地黍、岩谷伞、匍匐滨藜、榈木、锯齿草、穿心莲、滇苦菜，用流动的自来水冲洗干净，晾干，用水提取3次，合并提取液，浓缩至相对密度为1.20，按1:1.2的体积比加入浓度为60％的乙醇低温冷藏静置处理30小时，滤过，回收乙醇，用明胶作为絮凝剂除去色素，浓缩成70℃下相对密度为0.95的清膏,得到中药有效成分a，待用；
(2)按配方称取蚌兰叶、冻青叶，用流动的自来水冲洗干净，晾干，用粉碎机粉碎成40目的粗粉，置于干燥机内干燥至含水量低于3％，取出，晾凉，超微粉碎至300目，得到有效成分b，待用；
(3)按配方称取新鲜的兔毛蒿、甜瓜叶、对叶草、光叶水苏，洗净，入榨机榨出汁液，冷藏，过滤，除去杂质和沉淀，脱色处理，浓缩至含水量为40～45％，再加入0.2％的抗氧化剂，得到有效成分c，待用；
(4)按配方称取葡萄籽，粉碎，用7倍量的质量浓度为65％的甲醇，在70℃回流提取3次，每次提取60min，冷却抽滤，合并滤液，减压回收至无溶媒滴出，提取出葡萄籽油，得到有效成分d，待用；
(5)在配药罐中将上述所制得的中药有效成分a、中药有效成分b、中药有效成分c、有效成分d混合，得到总有效成分，按1:6.3的重量比例加入注射用水，再加入1.0％的表面活性剂、0.05％的助悬剂、0.02％的稳定剂，超声分散28分钟，高压蒸汽灭菌，灭菌的压力为103KPa，温度为121℃，持续时间为15分钟，灭菌完成后分装于喷雾容器中，即可。所述表面活性剂为氯化十六烷基吡啶(CPC)或吐温80；所述助悬剂为甲基纤维素、壳聚糖、西黄蓍胶、卡波姆或聚维酮；所述所述稳定剂为泊洛沙姆407。
临床治疗情况：
1、临床资料：选取某医院收治的麦粒肿患者200例，年龄5～26岁。主要临床表现为：眼睑皮肤局限性红、肿、热、痛，邻近球结膜水肿；当脓液局限积聚时出现黄色脓头，外麦粒肿发生在睫毛根部皮脂腺，表现在皮肤面，内麦粒肿发生在睑板腺，表现在结膜面，破溃排脓后疼痛缓解，红肿消退；重者伴有耳前、颌下淋巴结大及压痛、全身畏寒、发热等。
2、治疗方法：用本发明实施例2制备的复方中药制剂喷涂于眼睑内，每次喷涂1～2g，每日2～3次，7日为一个疗程，共使用3个疗程。
3、治疗标准：治愈：症状完全消失，红肿消散或脓液排出，疮口平复；有效：红肿缩小，症状减轻；无效：症状未改善，或溃后硬结不消复发。
4、治疗结果见表1：
表1：3个疗程内疗效统计
| 不同时间疗效 | 治愈/人 | 有效/人 | 无效/人 | 有效率/％ | 治愈率/％ |
| 1个疗程 | 106 | 82 | 12 | 94 | 53 |
| 2个疗程 | 135 | 59 | 6 | 98 | 67.5 |
| 3个疗程 | 149 | 48 | 3 | 98.5 | 74.5 |
治疗过程中，为见患者有不良反应，半年后，对200例患者进行复查，治愈后的患者中无一复发。
5、结论：经统计计算，本发明用于治疗麦粒肿的中西药复方外用制剂在一个疗程内治愈率达78％，总有效率达97％，两个疗程内治愈率达89.25％，总有效率达98.75％，三个疗程内治愈率达96.5％，总有效率达99.5％；并且在治疗过程中，未见任何不良反应或副作用，复发率为零，说明本发明用于治疗麦粒肿的中西药复方外用制剂疗效显著，复发率低，且安全无副作用。
以上所述是本发明的优选实施方式，其目的在于让熟悉此项技术的人了解本发明内容并加以实施，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以做出若干改进和润饰，这些改进和润饰也视为本发明的保护范围。
Claims (7)
1.一种治疗麦粒肿的复方中药制剂，其特征在于，按重量组份计，是由以下原料组成：葫芦茶根8～20份、望江青10～15份、兔毛蒿6～15份、岩谷伞6～14份、蚌兰叶5～15份、对叶草6～12份、铺地黍5～9份、匍匐滨藜6～10份、甜瓜叶2～8份、葡萄籽1～7份、锯齿草3～5份、冻青叶1～5份、光叶水苏2～5份、榈木1～3份、穿心莲1～4份、滇苦菜2～3份。
2.如权利要求1所述的一种治疗麦粒肿的复方中药制剂，其特征在于，按重量组份计，是由以下原料组成：葫芦茶根14份、望江青12.5份、兔毛蒿10.5份、岩谷伞10份、蚌兰叶10份、对叶草9份、铺地黍7份、匍匐滨藜8份、甜瓜叶5份、葡萄籽4份、锯齿草4份、冻青叶3份、光叶水苏3.5份、榈木2份、穿心莲2.5份、滇苦菜2.5份。
3.如权利要求1或2所述的一种治疗麦粒肿的复方中药制剂的制备方法，其特征在于，包括以下步骤：
(1)按配方称取葫芦茶根、望江青、铺地黍、岩谷伞、匍匐滨藜、榈木、锯齿草、穿心莲、滇苦菜，用流动的自来水冲洗干净，晾干，用水提取2～3次，合并提取液，浓缩至相对密度为1.10～1.20，按1:(1.0～1.2)的体积比加入浓度为50～60％的乙醇低温冷藏静置处理10～30小时，滤过，回收乙醇，用明胶作为絮凝剂除去色素，浓缩成70℃下相对密度为0.75～0.95的清膏,得到中药有效成分a，待用；
(2)按配方称取蚌兰叶、冻青叶，用流动的自来水冲洗干净，晾干，用粉碎机粉碎成20～40目的粗粉，置于干燥机内干燥至含水量低于3％，取出，晾凉，超微粉碎至200～300目，得到有效成分b，待用；
(3)按配方称取新鲜的兔毛蒿、甜瓜叶、对叶草、光叶水苏，洗净，入榨机榨出汁液，冷藏，过滤，除去杂质和沉淀，脱色处理，浓缩至含水量为40～45％，再加入0.1～0.2％的抗氧化剂，得到有效成分c，待用；
(4)按配方称取葡萄籽，粉碎，用5～7倍量的质量浓度为65％的甲醇，在60～70℃回流提取3次，每次提取30～60min，冷却抽滤，合并滤液，减压回收至无溶媒滴出，提取出葡萄籽油，得到有效成分d，待用；
(5)在配药罐中将上述所制得的中药有效成分a、中药有效成分b、中药有效成分c、有效成分d混合，得到总有效成分，按1:4.5～6.3的重量比例加入注射用水，再加入0.4～1.0％的表面活性剂、0.01～0.05％的助悬剂、0.01～0.02％的稳定剂，超声分散25～28分钟，高压蒸汽灭菌，分装于喷雾容器中，即可。
4.如权利要求3所述的一种治疗麦粒肿的复方中药制剂，其特征在于，所述表面活性剂为氯化十六烷基吡啶(CPC)或吐温80。
5.如权利要求3所述的一种治疗麦粒肿的复方中药制剂，其特征在于，所述助悬剂为甲基纤维素、壳聚糖、西黄蓍胶、卡波姆或聚维酮中的任意一种或几种。
6.如权利要求3所述的一种治疗麦粒肿的复方中药制剂，其特征在于，所述所述稳定剂为泊洛沙姆407。
7.如权利要求3所述的一种治疗麦粒肿的复方中药制剂的制备方法，其特征在于，所述步骤(5)中高压蒸汽灭菌的压力为101～103KPa，温度为121℃，持续时间为8～15分钟。
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