CN105640797B - Dihydromyricetin and application of the bletilla polysaccharide composition in beautifying whitening - Google Patents
Dihydromyricetin and application of the bletilla polysaccharide composition in beautifying whitening Download PDFInfo
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- CN105640797B CN105640797B CN201610079902.8A CN201610079902A CN105640797B CN 105640797 B CN105640797 B CN 105640797B CN 201610079902 A CN201610079902 A CN 201610079902A CN 105640797 B CN105640797 B CN 105640797B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The present invention relates to a kind of bletilla polysaccharides and dihydromyricetin compatibility to have effects that the compounding side of beautifying whitening.Take acrylic acid, the water of 4~15 times of weight is added, after acrylic acid is completely dissolved, bletilla polysaccharide dissolving is added, obtain mixture, 10% ammonium persulfate and TEMED are added, quickly room temperature decentralization is set 1~3 hour after mixing, and the water accumulated with three times to pentaploid flushes three times, add bletilla polysaccharide and dihydromyricetin, after being uniformly mixed, 20~50min of processing, vacuum drying make its water content be reduced to 20~30% or less to ultrasonic wave at once.The method makes full use of bletilla polysaccharide that can be obviously promoted the solubility of dihydromyricetin, but ensures the pH value slant acidity of its solution again simultaneously, is also conducive to the stability of dihydromyricetin.
Description
Technical field：
The present invention relates to a kind of bletilla polysaccharides and application of the dihydromyricetin promotor composition in beautifying whitening, belong to crude drug
The technical field of object application.
Background technology
Dihydromyricetin is that ampelopsis grossdentata is also known as one of main active ingredient of vine tea, is civil traditional medication, once
It is widely used in treating the infectious diseases such as skin disease, furuncle and osteomyelitis, acute lymphoblastic inflammation, a variety of harmful levels of pathogens can be inhibited.
Solubility is 4% in 25 DEG C of water, solubility bigger in hot water；It is soluble in methanol, ethyl alcohol and acetone, it is atomic to be dissolved in acetic acid second
Ester；It is insoluble in chloroform, petroleum ether.Lin Shuying etc. investigates DMY stability and influence factor, it was demonstrated that dihydromyricetin is molten
Liquid easily aoxidizes, and stability is poor, and no more than 100 DEG C, heating time is no more than 30min and acid and neutrallty condition can
Keep its steady chemical structure, and transiting state metal ion A l3+、Fe3+、Cu2+Inducing catalysis is played Deng to the oxidation of dihydromyricetin
Effect.
The Chinese patent of Publication No. CN1419906 discloses a kind of spot removing nutrient liquid, sweet by being added in liquid panax ginseng extractum
Oil, vitamin E, vitamin C, hyaluronic acid, distilled water mixing obtain required product.The product of the present invention can control sparrow
Spot, and can be with skin care, the skin after treatment is fair, and rich in gloss, curative effect is lasting, without any side effects.
The Chinese patent of Publication No. CN101700212A discloses a kind of production method of anti-aging moisturizer, including tea
Polyphenol, SOD, kojic acid palmitate, vitamin A, Rhizoma Atractylodis Macrocephalae, PORIA ALBA, bletilla, the root of Dahurain angelica, radix ampelopsis successively pass through by a certain percentage
The processes such as crushing, mixing, addition decoction, filtering, filter residue, reverse osmosis concentration, heating for dissolving, stirring are produced.Using this hair
The product of bright making can smooth away wrinkles, color spot, prevent the loss of moisture, keep skin wet, have whitening, nti-freckle, smoothing wrinkle,
Moisturizing, anti-aging function.
The Chinese patent of Publication No. CN101744971A discloses a kind of beauty treatment and eliminating spot combination liquid and preparation method thereof, should
Beauty treatment and eliminating spot combination liquid is made of the following raw material：Safflower, muskone, Ai Fen, pearl powder, RADIX PAEONIAE ALBA, aloe, kermes celestial being
The palm.Beauty treatment and eliminating spot prepared by the present invention combines liquid, to freckle, acne, acne, blackhead, chloasma, withered and yellow black face, senile plaque and
The effect of sunburn, is notable, and total effective rate reaches 98% or more, and whiteness of skin is delicate, high resilience.Also have to acne simultaneously
There is certain curative effect.
Bletilla polysaccharide belongs to the smaller natural polymer of molecular weight, but no antigen, without pyrogenicity, with animal body group
Knit it is preferably compatible, and can by slowly degradation absorb.Medical personal repairs damaged group using the excellent performance of bletilla glue
It knits, making certain surgical disease treatments that need not perform the operation can also solve.For example, Zhu Zhian etc. is by bletilla glue and by the de- of specially treated
Plyability biology skull material is made in calcium bone, is used for repair skull defect, in compatibility, plasticity, free constancy, and disappears
Very satisfied effect is obtained in terms of malicious hardenability.To the phlegm pipe case after certain perforated ulcers, anastomosis, with oral bletilla
Glue or bletilla treated powder have preferable filling repair.Partial interventional therapy technology (chemotherapy) is widely used in pernicious swollen
Tumor is faced.High concentration medicine embolism chemical therapeutic is given from diseased region is intravascular, malignant tumour can be made obviously downright bad, patient survival is prolonged
Long, survival rate improves.But chemotherapy is often with suppository such as gelatin, sponge, autologous thrombin block, stainless steel coil etc., and all there is many
Deficiency causes the long-term curative effect of chemotherapy not satisfied.Bletilla gluing resultant force is strong, and meeting water can slowly expand, and degradation absorbs slowly,
Clinical treatment as chemoembolization agent for internal organs bleeding, hemostasis and malignant tumour, is all up in different tube diameters blood vessel
Complete embolization effect, and can be mixed with various antitumor drugs, and not causing systemic medication adverse reaction, curative effect is obviously excellent
It is the comparatively ideal natural embolism materials of medium-term and long-term chemotherapy in gelatin, sponge embolism.Research has shown that, excessive in animal body
Free radical can cause cellular damage and death, and skin aging and wrinkle is accelerated to generate.Rui Haiyun etc. is the study found that bletilla is neutral
Polysaccharide has the apparent ability for removing free radical, and scavenging capacity is higher than vitamin E.Bletilla glue can be used as delaying skin and declines accordingly
Old trophism cosmetic material.
Bletilla gumminess excellent, comparable to Arabic gum, tragacanth gum, can be used as food, cosmetic field thickener,
Suspending agent, moisturizer and assistant for emulsifying agent are alternatively arranged as the host material of good excipient, powder, film, gelling agent.Bletilla
Glue, bletilla alkaloid and bletilla other active components are inhibiting tumor cell proliferation, delay skin aging, and thicken,
Suspension, moisturizing help emulsification and excipient etc. to have extensive market prospects.The especially Rhizoma Bletillae of different molecular weight,
There is extremely vast market prospect in terms of hemostasia and promoting granulation new drug development.
Invention content
Although dihydromyricetin energy removing chloasma and antibacterial action, solubility is little in water, itself does not have stickiness, Wu Fachang
Time is fixed on a certain position, and dihydromyricetin solution easily aoxidizes, and stability is poor.Bletilla polysaccharide can be in skin surface shape
At thin film, water imbibition is stronger, has skin moisturization.Since bletilla polysaccharide molecule itself is smaller, skin can be passed through
It directly absorbs, the metabolism of skin can be promoted, achieve the effect that skin-active, but removing chloasma and antibacterial effect are not so good as dihydromyricetin
It is plain apparent.
Therefore, first purpose of the invention is to provide a kind of bletilla polysaccharide has beautifying whitening work(with dihydromyricetin compatibility
The multiple formulation product of effect：10~25 parts of acrylic acid is taken, the water of 4~15 times of weight is added, after acrylic acid is completely dissolved, is added white
And 5~15 parts of dissolvings of polysaccharide, mixture is obtained, then 10% ammonium persulfate and TEMED are added into mixture, quickly room temperature after mixing
Lower to place 1~3 hour, the water accumulated with three times to pentaploid flushes three times, and adds 30~85 parts of bletilla polysaccharide and dihydromyricetin
5~15 parts of element, after being uniformly mixed, ultrasonic wave 20~50min of processing at once, vacuum drying make its water content be reduced to 20~
30% using vacuum packaging hereinafter, saved backup.
In one embodiment, beautifying whitening product is made of each raw material composition with following parts by weight：Take acrylic acid
15~20 parts, the water of 4~10 times of weight is added, after acrylic acid is completely dissolved, 10~15 parts of dissolvings of bletilla polysaccharide is added, obtain mixed
Object is closed, then 10% ammonium persulfate and TEMED are added into mixture, quickly room temperature decentralization is set 1~3 hour after mixing, with three times
The water accumulated to pentaploid flushes three times, and adds 10~15 parts of 35~70 parts of bletilla polysaccharide and dihydromyricetin, is stirred
After even, 20~50min of processing, vacuum drying make its water content be reduced to 20~30% hereinafter, using vacuum packet to ultrasonic wave at once
Dress saves backup.
In a specific embodiment, beautifying whitening product is made of each material composition with following parts by weight：Take third
The water of 10 times of weight is added in 15 parts of olefin(e) acid, after acrylic acid is completely dissolved, 10 parts of dissolvings of bletilla polysaccharide is added, obtain mixture, then
10% ammonium persulfate and TEMED are added into mixture, quickly room temperature decentralization is set 1~3 hour after mixing, the water accumulated with pentaploid
It flushes three times, adds 15 parts of 60 parts of bletilla polysaccharide and dihydromyricetin, after being uniformly mixed, ultrasonic wave processing 20 at once~
50min, vacuum drying make its water content be reduced to 20~30% hereinafter, being saved backup using vacuum packaging.
Second purpose of the invention is to provide a kind of specific preparation method of beautifying whitening product, and step includes：
(a) 10~25 parts of acrylic acid is taken, the water of 4~15 times of weight is added, after acrylic acid is completely dissolved, it is more that bletilla is added
5~15 parts of dissolvings of sugar, obtain mixture；
(b) 10% ammonium persulfate and TEMED is added into mixture again, quickly room temperature decentralization is set 1~3 hour after mixing,
It is rinsed with the water that three times to pentaploid are accumulated, obtains jelly；
(c) 5~15 parts of 10~25 parts of bletilla polysaccharide and dihydromyricetin is added into jelly again, is uniformly mixed
Afterwards, 20~50min of processing, vacuum drying make its water content be reduced to 20~30% hereinafter, using vacuum packaging to ultrasonic wave at once
It saves backup.
In one embodiment, the volume mL ratios of the volume μ L of 10% ammonium persulfate described in step (b) and mixture
It is 20~40：100；The volume μ L of TEMED (tetramethylethylenediamine) and the volume mL ratios of mixture are 20~40：100.
Third purpose of the present invention is to provide a kind of preparation method of bletilla polysaccharide, and it is used for beautifying whitening product
In, step includes：
(1) dry bletilla is crushed, after 10~30min of petroleum ether and stirring is added, 1~3 small layered removal is stood and contains stone
The upper solution of oily ether obtains precipitation I.
(2) 80-90% ethanol waters are added into precipitation I, after 30~80min is extracted in stirring, stand 50~140min,
Upper solution of the layering removal containing ethyl alcohol, obtains precipitation II.
(3) a certain amount of water is added into precipitation II, is heated with stirring to 70-85 DEG C, after keeping the temperature 30~80min, 5000rpm
10~20min is centrifuged, supernatant is obtained, goes to precipitate.
(4) supernatant is concentrated under reduced pressure into certain volume at 50-65 DEG C, adds 95% ethyl alcohol to final concentration and reaches
75% or more, alcohol precipitation 10-20h are filtered, and it is bletilla polysaccharide to obtain filter residue.
In one embodiment, petroleum ether described in step (1) is the petroleum ether using 90~120 DEG C of boiling range specifications,
Its volume L is 2~4 with bletilla weight kg ratios：1.
In one embodiment, the volume L of 80-90% ethanol waters described in step (2) and bletilla weight kg ratios
It is 2~5：1.
In one embodiment, it is 2~4 that the volume L of water and bletilla weight kg ratios are added described in step (3)：1.
In one embodiment, certain volume described in step (4) refers to the 1/10-1/40 of original volume.
In one embodiment, it is filtered described in step (4)：Membrane aperture is that 0.22 μm of ceramic membrane filter is primary.
The preparation method of 10% ammonium persulfate is to weigh 10g ammonium persulfates, after water dissolution, is settled to 100ml.
Above-mentioned beautifying whitening product or bletilla polysaccharide can be directly used in the hemostasis of various patient wounds, skin healing etc.
In material, the application of water-keeping material etc. in cosmetics is also can be directly used for, can be used for inhibiting the doctors such as various pathogens
With in material.
Technique effect
1, the method for the present invention is easy to operate, does not need precision instrument or automation equipment, township that can be resourceful in bletilla
Town enterprise is produced, this greatly reduces the production cost of bletilla polysaccharide, simplifies production process.
2, bletilla polysaccharide of the present invention has various opsonic actions, and Small side effects, haemostatic effect is fast.
3, dihydromyricetin can significantly play inhibition pathogen growth in wound location in beautifying whitening product of the invention, promote
It is acted on into wound healing.
4, aldehydes matter in bletilla is removed by ether and alcohol steep, can effectively prevent obtained product in preservation process
The problems such as middle discoloration.
5, by high temperature water extraction to improve the utilization rate of starch in bletilla, also it is conducive to the fast quick-release of bletilla glue (polysaccharide)
It puts, improves the utilization rate of bletilla, reduce bletilla usage amount.
Specific implementation mode
In the following, the present invention will be further detailed with embodiment, but its any for being not limited to these examples
A or similar example.
Embodiment 1：The preparation method of bletilla polysaccharide
Dry bletilla 100kg is crushed, after being directly added into the petroleum ether and stirring 20min of 200L, stands 1.5 small layered removals
Upper solution containing petroleum ether obtains precipitation I；85% ethanol water of 250L, stirring extraction 50min are added into precipitation I
Afterwards, 90min is stood, upper solution of the layering removal containing ethyl alcohol obtains precipitation II.A certain amount of 300L water is added into precipitation II,
85 DEG C are heated with stirring to, after keeping the temperature 35min, 5000rpm centrifuges 20min, obtains supernatant, goes to precipitate.Supernatant is at 50-65 DEG C
It is concentrated under reduced pressure into the 1/20 of original volume, 95% ethyl alcohol to final concentration is added and reaches 75% or more, alcohol precipitation 10-20h, is carried out
0.22 μm of ceramic membrane filter is primary that filter residue is bletilla polysaccharide product.It is measured through anthrone-sulphate method, it is solvable in product
Property sugared content is 99.5% or more.
Embodiment 2：The preparation of beautifying whitening product
15 grams of acrylic acid is taken, 100 grams of water is added, after acrylic acid is completely dissolved, 10 grams of dissolvings of bletilla polysaccharide is added, obtain
Mixture 100mL or so；10% ammonium persulfate, 25 μ L and TEMED20 μ L are added into mixture again, quickly after mixing at room temperature
It places 2 hours, is rinsed three times with the water of 500mL, obtains jelly；60 grams of bletilla polysaccharide and dihydro is added into jelly again
15 grams of myricetin, after being uniformly mixed, processing 40min, vacuum drying make its water content be reduced to 20% left side to ultrasonic wave at once
The right side is obtained 120 grams of beautifying whitening product, is saved backup using vacuum packaging.
Embodiment 3：The preparation of beautifying whitening product
30 grams of acrylic acid is taken, 150 grams of water is added, after acrylic acid is completely dissolved, 15 grams of dissolvings of bletilla polysaccharide is added, obtain
Mixture 150mL or so；10% ammonium persulfate, 35 μ L and TEMED30 μ L are added into mixture again, quickly after mixing at room temperature
It places 3 hours, is rinsed three times with the water of 600mL, obtains jelly；120 grams of bletilla polysaccharide and two are added into jelly again
35 grams of hydrogen myricetin, after being uniformly mixed, processing 40min, vacuum drying make its water content be reduced to 25% to ultrasonic wave at once
Left and right is obtained 260 grams of beautifying whitening product, is saved backup using vacuum packaging.
Embodiment 4：The antioxidation of various products
Bletilla polysaccharide is prepared：30mL water is added in 40 grams of the bletilla polysaccharide that embodiment 1 is obtained to be made.Dihydromyricetin is molten
Liquid：20 grams of dihydromyricetins 100mL absolute ethyl alcohols dissolve, and obtain dihydromyricetin alcoholic solution.0.08mmol/LDPPH solution
It prepares：Precision weighs DPPH8.0mg, is dissolved and is settled in 200mL brown volumetric flasks with absolute ethyl alcohol, obtained a concentration of
0.004% DPPH solution, is kept in dark place, spare.After various sample 5g are placed at room temperature for a period of time, using DPPH reagents into
The measurement of row antioxidation is shown in Table 1.Activity of the antioxidant activity of the beautifying whitening product of the present invention than otherwise processed
By force, the vigor that can more effectively improve human epidermal cell plays reparation epidermal cell, keeps epidermal cell activity.
1 beautifying whitening product of table is to DPPH antioxidations
It is attached：DPPH methods measure oxidation resistant specific method：Take respectively different trials each sample solution (0.24,0.48,
0.72,0.96,1.20mg/mL) 1.0mL is set in 10mL centrifuge tubes, and the DPPH solution of 3.0mL is added, and room temperature is protected from light
30min, while using absolute ethyl alcohol as blank, light absorption value is measured at 517nm wavelength.DPPH is calculated according to the following formula freely to remove
Rate.
The free clearance rates of DPPH (%)=A0-(AS-Ac)/A0× 100%
In formula, A0The absorbance value of -1.0mL distilled water+3.0mLDPPH solution
ASThe absorbance value of -1.0mL sample solution+3.0mLDPPH solution
AcThe absorbance value of -1.0mL sample solution+3.0mL absolute ethyl alcohols
It will test in triplicate, and acquire the average on duty for the day of clearance rate.
Claims (10)
1. a kind of bletilla polysaccharide has effects that the multiple formulation product of beautifying whitening with dihydromyricetin compatibility, it is characterised in that：It takes
The water of 4~15 times of weight is added in 10~25 parts of acrylic acid, and after acrylic acid is completely dissolved, it is molten that 5~15 parts of bletilla polysaccharide is added
Solution, obtains mixture, then 10% ammonium persulfate and TEMED are added into mixture, and quickly room temperature decentralization is set 1~3 hour after mixing,
The water accumulated with three times to pentaploid flushes three times, and adds 5~15 parts of 30~85 parts of bletilla polysaccharide and dihydromyricetin, and stirring is mixed
After closing uniformly, 20~50min of processing, vacuum drying make its water content be reduced to 20~30% hereinafter, using vacuum to ultrasonic wave at once
Packaging saves backup.
2. product as described in claim 1, it is characterised in that be made of with following parts by weight each raw material composition：Take acrylic acid
15~20 parts, the water of 4~10 times of weight is added, after acrylic acid is completely dissolved, 10~15 parts of dissolvings of bletilla polysaccharide is added, obtain mixed
Object is closed, then 10% ammonium persulfate and TEMED are added into mixture, quickly room temperature decentralization sets 1~3 hour after mixing, extremely with three times
The water of pentaploid product flushes three times, and adds 10~15 parts of 35~70 parts of bletilla polysaccharide and dihydromyricetin, is uniformly mixed
Afterwards, 20~50min of processing, vacuum drying make its water content be reduced to 20~30% hereinafter, being protected using vacuum packaging to ultrasonic wave at once
It deposits spare.
3. product as described in claim 1, it is characterised in that be made of with following parts by weight each material composition：Take acrylic acid
15 parts, the water of 10 times of weight is added, after acrylic acid is completely dissolved, the dissolving of 10 parts of bletilla polysaccharide is added, obtains mixture, then to mixed
It closes in object and 10% ammonium persulfate and TEMED is added, quickly room temperature decentralization is set 1~3 hour after mixing, is rinsed with the water that pentaploid accumulates
Three times, 15 parts of 60 parts of bletilla polysaccharide and dihydromyricetin are added, after being uniformly mixed, ultrasonic wave processing 20 at once~
50min, vacuum drying make its water content be reduced to 20~30% hereinafter, being saved backup using vacuum packaging.
4. the specific preparation method of the product as described in one of claim 1-3, it is characterised in that step includes：
（a）10~25 parts of acrylic acid is taken, the water of 4~15 times of weight is added, after acrylic acid is completely dissolved, bletilla polysaccharide 5 is added
~15 parts of dissolvings, obtain mixture；
（b）10% ammonium persulfate and TEMED is added into mixture again, quickly room temperature decentralization is set 1~3 hour after mixing, with three times
The water accumulated to pentaploid rinses, and obtains jelly；
（c）5~15 parts of 10~25 parts of bletilla polysaccharide and dihydromyricetin is added into jelly again, after being uniformly mixed, surpasses
20~50min of processing, vacuum drying make its water content be reduced to 20~30% hereinafter, being preserved using vacuum packaging standby to sound wave at once
With.
5. method as claimed in claim 4, it is characterised in that the volume μ L of 10% ammonium persulfate described in step (b) with mix
The volume mL ratios of object are 20~40：100；The volume μ L of TEMED and the volume mL ratios of mixture are 20~40：100.
6. the preparation method of the bletilla polysaccharide as described in one of claims 1 to 3, and it is used in beautifying whitening product,
It is characterized in that step includes：
（1）Dry bletilla is crushed, after 10~30min of petroleum ether and stirring is added, 1~3 small layered removal is stood and contains stone
The upper solution of oily ether obtains precipitation I.
（2）80-90% ethanol waters are added into precipitation I, after 30~80min is extracted in stirring, stand 50~140min,
Upper solution of the layering removal containing ethyl alcohol, obtains precipitation II.
（3）A certain amount of water is added into precipitation II, is heated with stirring to 70-85 DEG C, after keeping the temperature 30~80min, 5000rpm
10~20min is centrifuged, supernatant is obtained, goes to precipitate.
（4）Supernatant is concentrated under reduced pressure into the 1/10-1/40 of original volume at 50-65 DEG C, it is dense to end to add 95% ethyl alcohol
Degree reaches 75% or more, and alcohol precipitation 10-20 h are filtered, and it is bletilla polysaccharide to obtain filter residue.
7. method as claimed in claim 6, it is characterised in that petroleum ether described in step (1) is to use 90~120 DEG C of boiling ranges
The petroleum ether of specification, volume L are 2~4 with bletilla weight kg ratios：1.
8. method as claimed in claim 6, it is characterised in that the volume L of 80-90% ethanol waters described in step (2) with
Bletilla weight kg ratios are 2~5：1.
9. method as claimed in claim 6, it is characterised in that the volume L and bletilla weight of water are added described in step (3)
It is 2~4 to measure kg ratios：1.
10. bletilla polysaccharide preparation method obtains as described in one of product or claim 6~9 as described in one of claims 1 to 3
Bletilla polysaccharide, it is characterised in that be used directly in the hemostasis of various patient wounds, skin healing material, also can be direct
For the application in terms of water-keeping material in cosmetics, can be used for inhibiting in various pathogen medical materials.
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| WO2007122251A2 (en) * | 2006-04-25 | 2007-11-01 | Symrise Gmbh & Co. Kg | Synergistic mixture of glycosyl flavanones and xanthines |
| CN101380281A (en) * | 2008-09-26 | 2009-03-11 | 中华全国供销合作总社南京野生植物综合利用研究院 | Paeonol bletilla striata polysaccharide clathrate and preparation technique and use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007122251A2 (en) * | 2006-04-25 | 2007-11-01 | Symrise Gmbh & Co. Kg | Synergistic mixture of glycosyl flavanones and xanthines |
| CN101380281A (en) * | 2008-09-26 | 2009-03-11 | 中华全国供销合作总社南京野生植物综合利用研究院 | Paeonol bletilla striata polysaccharide clathrate and preparation technique and use thereof |
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| 《二氢杨梅素的制备及其对酪氨酸酶的抑制研究》;王小洪;《应用化工》;20121231;第41卷(第12期);第2109-2111页 * |
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